Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.9
USERS' SCORE
Good
Based on 6 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Calories
5
Total Carbohydrate
1 g
<1%**
Vitamin C(as Ester C® calcium ascorbate)
1,000 mg
1,111%
Calcium(as Ester-C® calcium ascorbate)
100 mg
8%
Citrus BioflavonoidComplex
200 mg
***
Acerola Extract
25 mg
***
Rose Hips (fruit)
25 mg
***
Rutin
25 mg
***
Top Medical Research Studies
9
We observed a fascinating phenomenon related to vitamin C and anemia during a series of cases in a prison setting in Ethiopia. Specifically, we examined how scurvy, a disease caused by a lack of vitamin C, contributed to anemia among prisoners.
Our study focused on ten patients who were admitted for treatment, all of whom presented with some form of leg swelling or pain. After administering vitamin C in the form of ascorbic acid, we noted a significant increase in hemoglobin levels, rising from an average of 4.6 to 7.1 g/dL. This improvement indicates that vitamin C may play a crucial role in alleviating some anemia symptoms when the underlying cause is related to dietary deficiencies.
Additionally, through an observational study involving 67 other patients in the same prison, we confirmed that leg swelling and pain were common symptoms among those affected. With consistent therapeutic doses of vitamin C, all patients showed considerable improvement in their conditions.
Thus, we can conclude that vitamin C does seem to have a valuable effect on anemia caused by dietary deficiencies, particularly in high-risk environments like prisons. This finding encourages healthcare providers to remain vigilant about such nutritional deficiencies and highlights the importance of vitamin C in treatment.
Our study focused on ten patients who were admitted for treatment, all of whom presented with some form of leg swelling or pain. After administering vitamin C in the form of ascorbic acid, we noted a significant increase in hemoglobin levels, rising from an average of 4.6 to 7.1 g/dL. This improvement indicates that vitamin C may play a crucial role in alleviating some anemia symptoms when the underlying cause is related to dietary deficiencies.
Additionally, through an observational study involving 67 other patients in the same prison, we confirmed that leg swelling and pain were common symptoms among those affected. With consistent therapeutic doses of vitamin C, all patients showed considerable improvement in their conditions.
Thus, we can conclude that vitamin C does seem to have a valuable effect on anemia caused by dietary deficiencies, particularly in high-risk environments like prisons. This finding encourages healthcare providers to remain vigilant about such nutritional deficiencies and highlights the importance of vitamin C in treatment.
9
Nano-Bhasma enhances iron absorption
We investigated how modifying Mandoor Bhasma, a traditional Ayurvedic medicine, could enhance its effectiveness in treating iron-deficiency anemia. By grinding this medicine into nanoparticles and coating them with ascorbic acid, we aimed to boost the iron bioavailability in our body.
In our study, we found that the surface-enhanced nano-Mandoor Bhasma exhibited better iron dissolution in conditions similar to those found in our intestines. This improvement was significant because it means that more iron becomes available for our bodies to absorb. Testing the effects on human colon cells revealed that cells treated with the modified version absorbed three times more iron compared to those treated with the standard version.
Furthermore, as the treated cells produced higher levels of a key protein related to iron storage, this signals an increase in the iron available for our body’s needs. Ultimately, this research suggests that using nanoscale formulations and vitamin C can significantly enhance the effectiveness of traditional iron treatments for anemia.
In our study, we found that the surface-enhanced nano-Mandoor Bhasma exhibited better iron dissolution in conditions similar to those found in our intestines. This improvement was significant because it means that more iron becomes available for our bodies to absorb. Testing the effects on human colon cells revealed that cells treated with the modified version absorbed three times more iron compared to those treated with the standard version.
Furthermore, as the treated cells produced higher levels of a key protein related to iron storage, this signals an increase in the iron available for our body’s needs. Ultimately, this research suggests that using nanoscale formulations and vitamin C can significantly enhance the effectiveness of traditional iron treatments for anemia.
9
Novel chelate complex boosts iron
We examined a novel approach to combat iron deficiency anemia by focusing on a unique triple chelate complex that combines iron, vitamin C (ascorbic acid), and essential amino acids. Our findings revealed that this complex can effectively increase iron levels in the body, particularly in fermented dairy products.
Importantly, we found that the fortification of milk with this complex doesn't require high concentrations—just a mere 0.005 mol/L is enough for effective results. Through our experiments with rat models, we observed a significant boost in serum iron levels after administering the complex, achieving a rise of 14.0 mmol/L within just 24 hours.
Furthermore, we studied how these complexes affected the taste and quality of dairy products, demonstrating that even at very low concentrations, they maintained desirable physicochemical properties. Among the various compounds we tested, iron ascorbate lysinate stood out as the most promising candidate for enhancing iron levels, making it a potential game-changer in diets for those suffering from iron deficiency anemia.
However, while we acknowledge the crucial role vitamin C plays in improving iron absorption, our focus on the triple chelate mechanism makes it challenging to isolate its individual effects solely on anemia.
Importantly, we found that the fortification of milk with this complex doesn't require high concentrations—just a mere 0.005 mol/L is enough for effective results. Through our experiments with rat models, we observed a significant boost in serum iron levels after administering the complex, achieving a rise of 14.0 mmol/L within just 24 hours.
Furthermore, we studied how these complexes affected the taste and quality of dairy products, demonstrating that even at very low concentrations, they maintained desirable physicochemical properties. Among the various compounds we tested, iron ascorbate lysinate stood out as the most promising candidate for enhancing iron levels, making it a potential game-changer in diets for those suffering from iron deficiency anemia.
However, while we acknowledge the crucial role vitamin C plays in improving iron absorption, our focus on the triple chelate mechanism makes it challenging to isolate its individual effects solely on anemia.
Most Useful Reviews
9.5
Overall health improvement
For treating anemia, I was prescribed Ester-C 1000 mg, taken with an iron supplement for better absorption. I experienced no side effects. My skin, nails, and hair have become healthier, and my overall condition has improved as acute respiratory infections stopped occurring. The dosage is generous, lasting a long time at an affordable price.
8.8
Effective treatment
Good quality! I really liked this manufacturer. I ordered it for the treatment of iron deficiency anemia. Ester-C® Plus is a unique formulation that offers a neutral (non-acidic) pH vitamin C that is easy on the stomach. The metabolites in Ester-C® help retain vitamin C in cells, providing additional benefits.
8.8
Highly digestible form
Excellent! I use this vitamin with iron in the morning for my anemia, as I don’t eat meat. This dosage and type are believed to be the most digestible.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.9
- All Researches
9
Nano-Bhasma enhances iron absorption
We investigated how modifying Mandoor Bhasma, a traditional Ayurvedic medicine, could enhance its effectiveness in treating iron-deficiency anemia. By grinding this medicine into nanoparticles and coating them with ascorbic acid, we aimed to boost the iron bioavailability in our body.
In our study, we found that the surface-enhanced nano-Mandoor Bhasma exhibited better iron dissolution in conditions similar to those found in our intestines. This improvement was significant because it means that more iron becomes available for our bodies to absorb. Testing the effects on human colon cells revealed that cells treated with the modified version absorbed three times more iron compared to those treated with the standard version.
Furthermore, as the treated cells produced higher levels of a key protein related to iron storage, this signals an increase in the iron available for our body’s needs. Ultimately, this research suggests that using nanoscale formulations and vitamin C can significantly enhance the effectiveness of traditional iron treatments for anemia.
In our study, we found that the surface-enhanced nano-Mandoor Bhasma exhibited better iron dissolution in conditions similar to those found in our intestines. This improvement was significant because it means that more iron becomes available for our bodies to absorb. Testing the effects on human colon cells revealed that cells treated with the modified version absorbed three times more iron compared to those treated with the standard version.
Furthermore, as the treated cells produced higher levels of a key protein related to iron storage, this signals an increase in the iron available for our body’s needs. Ultimately, this research suggests that using nanoscale formulations and vitamin C can significantly enhance the effectiveness of traditional iron treatments for anemia.
9
Novel chelate complex boosts iron
We examined a novel approach to combat iron deficiency anemia by focusing on a unique triple chelate complex that combines iron, vitamin C (ascorbic acid), and essential amino acids. Our findings revealed that this complex can effectively increase iron levels in the body, particularly in fermented dairy products.
Importantly, we found that the fortification of milk with this complex doesn't require high concentrations—just a mere 0.005 mol/L is enough for effective results. Through our experiments with rat models, we observed a significant boost in serum iron levels after administering the complex, achieving a rise of 14.0 mmol/L within just 24 hours.
Furthermore, we studied how these complexes affected the taste and quality of dairy products, demonstrating that even at very low concentrations, they maintained desirable physicochemical properties. Among the various compounds we tested, iron ascorbate lysinate stood out as the most promising candidate for enhancing iron levels, making it a potential game-changer in diets for those suffering from iron deficiency anemia.
However, while we acknowledge the crucial role vitamin C plays in improving iron absorption, our focus on the triple chelate mechanism makes it challenging to isolate its individual effects solely on anemia.
Importantly, we found that the fortification of milk with this complex doesn't require high concentrations—just a mere 0.005 mol/L is enough for effective results. Through our experiments with rat models, we observed a significant boost in serum iron levels after administering the complex, achieving a rise of 14.0 mmol/L within just 24 hours.
Furthermore, we studied how these complexes affected the taste and quality of dairy products, demonstrating that even at very low concentrations, they maintained desirable physicochemical properties. Among the various compounds we tested, iron ascorbate lysinate stood out as the most promising candidate for enhancing iron levels, making it a potential game-changer in diets for those suffering from iron deficiency anemia.
However, while we acknowledge the crucial role vitamin C plays in improving iron absorption, our focus on the triple chelate mechanism makes it challenging to isolate its individual effects solely on anemia.
9
We observed a fascinating phenomenon related to vitamin C and anemia during a series of cases in a prison setting in Ethiopia. Specifically, we examined how scurvy, a disease caused by a lack of vitamin C, contributed to anemia among prisoners.
Our study focused on ten patients who were admitted for treatment, all of whom presented with some form of leg swelling or pain. After administering vitamin C in the form of ascorbic acid, we noted a significant increase in hemoglobin levels, rising from an average of 4.6 to 7.1 g/dL. This improvement indicates that vitamin C may play a crucial role in alleviating some anemia symptoms when the underlying cause is related to dietary deficiencies.
Additionally, through an observational study involving 67 other patients in the same prison, we confirmed that leg swelling and pain were common symptoms among those affected. With consistent therapeutic doses of vitamin C, all patients showed considerable improvement in their conditions.
Thus, we can conclude that vitamin C does seem to have a valuable effect on anemia caused by dietary deficiencies, particularly in high-risk environments like prisons. This finding encourages healthcare providers to remain vigilant about such nutritional deficiencies and highlights the importance of vitamin C in treatment.
Our study focused on ten patients who were admitted for treatment, all of whom presented with some form of leg swelling or pain. After administering vitamin C in the form of ascorbic acid, we noted a significant increase in hemoglobin levels, rising from an average of 4.6 to 7.1 g/dL. This improvement indicates that vitamin C may play a crucial role in alleviating some anemia symptoms when the underlying cause is related to dietary deficiencies.
Additionally, through an observational study involving 67 other patients in the same prison, we confirmed that leg swelling and pain were common symptoms among those affected. With consistent therapeutic doses of vitamin C, all patients showed considerable improvement in their conditions.
Thus, we can conclude that vitamin C does seem to have a valuable effect on anemia caused by dietary deficiencies, particularly in high-risk environments like prisons. This finding encourages healthcare providers to remain vigilant about such nutritional deficiencies and highlights the importance of vitamin C in treatment.
9
We investigated how vitamin C can affect anemia, particularly through its interaction with a specific iron supplement called phosvitin peptide-ferrous complex. This complex is designed to enhance iron bioavailability, which is crucial in addressing iron deficiency anemia (IDA). Our analysis showed that when vitamin C was added to this complex, there was a notable increase in iron absorption.
The results indicated that the iron content increased significantly with the presence of vitamin C, which interacted synergistically to boost bioavailability. In fact, when vitamin C was added, the iron dialysis percentage increased, highlighting its potential role in improving the efficiency of iron absorption in the gut.
While our findings suggested significant benefits in enhancing iron absorption when combined with vitamin C, it's essential to recognize that the isolated effects of vitamin C on anemia were not fully evaluated in this study. Therefore, while the combination exhibited promising results, we can't definitively say that vitamin C alone provides a solution for anemia.
The results indicated that the iron content increased significantly with the presence of vitamin C, which interacted synergistically to boost bioavailability. In fact, when vitamin C was added, the iron dialysis percentage increased, highlighting its potential role in improving the efficiency of iron absorption in the gut.
While our findings suggested significant benefits in enhancing iron absorption when combined with vitamin C, it's essential to recognize that the isolated effects of vitamin C on anemia were not fully evaluated in this study. Therefore, while the combination exhibited promising results, we can't definitively say that vitamin C alone provides a solution for anemia.
8
Fortified beverage impacts anemia study
We explored the impact of a fortified beverage made from pearl millet and baobab pulp on the iron and anemia status of adolescent girls in rural Ghana. This was done through a cluster randomized controlled trial involving 258 participants. Girls were divided into three groups: one that received the fortified beverage, one that received an unfortified version, and another that got standard iron and folate supplements.
Importantly, the fortified beverage contained vitamin C, which is known to enhance iron absorption. However, the study didn't isolate the effects of vitamin C alone on anemia. Therefore, while we observed the positive potential of this fortified beverage, we can't definitively conclude that vitamin C had a direct impact.
Overall, the research aims to fill a gap in understanding how food-fortification strategies can fight iron deficiency anemia, which is a significant public health issue in this region. It’s exciting to think about how these findings might influence future dietary interventions for adolescent girls facing anemia.
Importantly, the fortified beverage contained vitamin C, which is known to enhance iron absorption. However, the study didn't isolate the effects of vitamin C alone on anemia. Therefore, while we observed the positive potential of this fortified beverage, we can't definitively conclude that vitamin C had a direct impact.
Overall, the research aims to fill a gap in understanding how food-fortification strategies can fight iron deficiency anemia, which is a significant public health issue in this region. It’s exciting to think about how these findings might influence future dietary interventions for adolescent girls facing anemia.
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Overall health improvement
For treating anemia, I was prescribed Ester-C 1000 mg, taken with an iron supplement for better absorption. I experienced no side effects. My skin, nails, and hair have become healthier, and my overall condition has improved as acute respiratory infections stopped occurring. The dosage is generous, lasting a long time at an affordable price.
8.8
Effective treatment
Good quality! I really liked this manufacturer. I ordered it for the treatment of iron deficiency anemia. Ester-C® Plus is a unique formulation that offers a neutral (non-acidic) pH vitamin C that is easy on the stomach. The metabolites in Ester-C® help retain vitamin C in cells, providing additional benefits.
8.8
Highly digestible form
Excellent! I use this vitamin with iron in the morning for my anemia, as I don’t eat meat. This dosage and type are believed to be the most digestible.
8.8
Improved iron absorption
Good vitamin C; I took it alongside iron medications from the pharmacy for better absorption and to replenish my iron deficiency due to anemia.
8.8
Recommended for anemia
Good quality! I ordered this for treating iron deficiency anemia and was pleased with the manufacturer. Ester-C® Plus, an exclusive Solgar® formulation, provides a patented vitamin C with a gentle, non-acidic pH level. The vitamin C metabolites aid in retaining vitamin C in cells, offering additional benefits.
Frequently Asked Questions
9.5
Overall health improvement
For treating anemia, I was prescribed Ester-C 1000 mg, taken with an iron supplement for better absorption. I experienced no side effects. My skin, nails, and hair have become healthier, and my overall condition has improved as acute respiratory infections stopped occurring. The dosage is generous, lasting a long time at an affordable price.
8.8
Highly digestible form
Excellent! I use this vitamin with iron in the morning for my anemia, as I don’t eat meat. This dosage and type are believed to be the most digestible.
8.8
Improved iron absorption
Good vitamin C; I took it alongside iron medications from the pharmacy for better absorption and to replenish my iron deficiency due to anemia.
8.8
Effective treatment
Good quality! I really liked this manufacturer. I ordered it for the treatment of iron deficiency anemia. Ester-C® Plus is a unique formulation that offers a neutral (non-acidic) pH vitamin C that is easy on the stomach. The metabolites in Ester-C® help retain vitamin C in cells, providing additional benefits.
8.8
Gentle on stomach
I take this for a friend; her doctor recommended it alongside iron for her anemia. She has a sensitive stomach but has had no complaints regarding this vitamin C.
7
Vitamin C enhances iron absorption
We conducted a study to explore the impact of adding vitamin C-rich guava to a traditional meal of mungbean dal on children’s anemia in rural India. Our randomized controlled trial involved 200 school-aged children, many of whom were found to be anemic and iron-deficient. We aimed to see if this simple addition could improve their hemoglobin levels and overall iron status.
The children in our study were divided into two groups. One group enjoyed a meal of mungbean dal alone, while the other had the same meal but with fresh guava included. Our findings revealed that the addition of guava, packed with vitamin C, significantly increased hemoglobin levels and reduced anemia in the children consuming the fortified meal.
However, despite these positive outcomes in hemoglobin, we observed that body iron stores did not increase significantly. This suggests that while vitamin C can enhance iron absorption, the combination may not provide enough iron to boost overall iron storage in the body. Thus, enriching meals with vitamin C-rich foods like guava is a promising strategy to combat anemia among children.
The children in our study were divided into two groups. One group enjoyed a meal of mungbean dal alone, while the other had the same meal but with fresh guava included. Our findings revealed that the addition of guava, packed with vitamin C, significantly increased hemoglobin levels and reduced anemia in the children consuming the fortified meal.
However, despite these positive outcomes in hemoglobin, we observed that body iron stores did not increase significantly. This suggests that while vitamin C can enhance iron absorption, the combination may not provide enough iron to boost overall iron storage in the body. Thus, enriching meals with vitamin C-rich foods like guava is a promising strategy to combat anemia among children.
8
Fortified beverage impacts anemia study
We explored the impact of a fortified beverage made from pearl millet and baobab pulp on the iron and anemia status of adolescent girls in rural Ghana. This was done through a cluster randomized controlled trial involving 258 participants. Girls were divided into three groups: one that received the fortified beverage, one that received an unfortified version, and another that got standard iron and folate supplements.
Importantly, the fortified beverage contained vitamin C, which is known to enhance iron absorption. However, the study didn't isolate the effects of vitamin C alone on anemia. Therefore, while we observed the positive potential of this fortified beverage, we can't definitively conclude that vitamin C had a direct impact.
Overall, the research aims to fill a gap in understanding how food-fortification strategies can fight iron deficiency anemia, which is a significant public health issue in this region. It’s exciting to think about how these findings might influence future dietary interventions for adolescent girls facing anemia.
Importantly, the fortified beverage contained vitamin C, which is known to enhance iron absorption. However, the study didn't isolate the effects of vitamin C alone on anemia. Therefore, while we observed the positive potential of this fortified beverage, we can't definitively conclude that vitamin C had a direct impact.
Overall, the research aims to fill a gap in understanding how food-fortification strategies can fight iron deficiency anemia, which is a significant public health issue in this region. It’s exciting to think about how these findings might influence future dietary interventions for adolescent girls facing anemia.
8
We observed a case where a 53-year-old woman suffered from a chronic, non-productive cough that didn't respond to specific treatments. After thorough examinations, she was found to have hypochromic microcytic anemia, characterized by low hemoglobin levels.
The treatment involved an oral nutraceutical capsule containing elemental iron, along with folic acid and vitamin C. Remarkably, her cough resolved after six months of this regimen. While vitamin C was part of the treatment, the significant focus was on iron, which is crucial for addressing anemia.
Therefore, while we can note the inclusion of vitamin C, its individual impact remains unclear due to the combination with iron and other vitamins. We conclude that ensuring adequate iron levels may help resolve symptoms like unexplained chronic cough tied to anemia.
The treatment involved an oral nutraceutical capsule containing elemental iron, along with folic acid and vitamin C. Remarkably, her cough resolved after six months of this regimen. While vitamin C was part of the treatment, the significant focus was on iron, which is crucial for addressing anemia.
Therefore, while we can note the inclusion of vitamin C, its individual impact remains unclear due to the combination with iron and other vitamins. We conclude that ensuring adequate iron levels may help resolve symptoms like unexplained chronic cough tied to anemia.
References
- Rani V, Moretti D, Khetarpaul N, Thankachan P, Zimmermann MB, et al. Vitamin C-Rich Guava Consumed with Mungbean Dal Reduces Anemia and Increases Hemoglobin but not Iron Stores: A Randomized Controlled Trial of Food-to-Food Fortification in Indian Children. J Nutr. 2024;154:3740. doi:10.1016/j.tjnut.2024.10.042
- Atosona A, Larbie C, Apprey C, Annan RA. Pearl millet instant beverage powder enriched with baobab pulp to improve iron and anaemia status of adolescent girls in rural Ghana: a study protocol for a cluster randomised controlled trial. Br J Nutr. 2024;132:565. doi:10.1017/S0007114524001430
- Wang X, Zhu X, Liu Y, Liu H, Xiao Z, et al. Efficacy of vitamin C on chemotherapy-related anemia in pancreatic cancer: study protocol for a randomized controlled trial. Trials. 2024;25:512. doi:10.1186/s13063-024-08345-w
- Balkrishna A, Bhattacharya K, Samanta HS, Tomer M, Varshney A. Advancements in Nano-Mandoor Bhasma: Unravelling the Particle Size-Ascorbic Acid Synergy for Enhanced Iron Bioavailability for Anemia Treatment. Biol Trace Elem Res. 2024. doi:10.1007/s12011-024-04304-3
- Gvozdenko A, Blinov A, Golik A, Rekhman Z, Nagdalian A, et al. Harnessing the Power of a Novel Triple Chelate Complex in Fermented Probiotic Dairy Products: A Promising Solution for Combating Iron Deficiency Anemia. ACS Omega. 2024;9:28594. doi:10.1021/acsomega.4c02664
- Akbari F, Vahedi Larijani L, Rajabi Visroodi E, Hakiminia B. Effect of the treatment of iron deficiency anemia on chronic drug-resistant cough: a rare case report. Daru. 2024;32:967. doi:10.1007/s40199-024-00522-1
- Haile A, Mara S, Belete Y, Dejene T. The Forgotten Disease in the 21st Century: Scurvy Outbreak in Hawassa Central Prison, Hawassa, Sidama, Southern Ethiopia, 2023. Int Med Case Rep J. 2023;16:847. doi:10.2147/IMCRJ.S438833
- Song L, Zhu L, Qiao S, Song L, Zhang M, et al. Preparation, characterization, and bioavailability evaluation of antioxidant phosvitin peptide-ferrous complex. J Sci Food Agric. 2024;104:3090. doi:10.1002/jsfa.13200
