Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.5
USERS' SCORE
Good
Based on 8 Reviews
8.2
Supplement Facts
Serving Size: 3 Tablets
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
25 mg
1,471%
Magnesium (as magnesium oxide)
400 mg
95%

Top Medical Research Studies

9
Magnesium intake reduces depression risk
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.

Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Read More
9
Vitamin B6 effectively battles depression
We explored the potential of vitamin B6 in treating depression, particularly how it compares to commonly used antidepressants. In our experiment, male mice were given a single dose of Bacillus-Calmette-Guerin (BCG) to induce depressive-like behaviors. Following this, we administered vitamin B6 alongside popular antidepressants such as fluoxetine, imipramine, and venlafaxine, to see how effectively each treatment mitigated symptoms over 14 days.

Our findings highlighted that vitamin B6 was effective in alleviating depression in the mice, just like the other antidepressant medications. The animals displayed significant improvements in both despair and anhedonia—key indicators of depression. Specifically, we noticed a decrease in immobility time during a forced swim test, indicating reduced despair. Plus, the latency to feed and food consumption improved significantly, showing that vitamin B6 helped counteract the depressive behaviors caused by BCG.

Overall, our research suggests that vitamin B6 can be a powerful ally in preventing depression, similar in effectiveness to some existing antidepressant drugs. We believe this opens the door for further clinical research on vitamin B6 as a potential treatment, especially for those at high risk for depression.
Read More
We conducted a study to explore how vitamin B6 affects postpartum depression (PPD) among mothers who are at risk. This clinical trial took place in Isfahan, Iran, with 81 pregnant women participating over several months in 2016.

Our approach involved a single-blind, placebo-controlled design, where 40 women received 80 mg of vitamin B6 while 41 others were given a placebo from the 28th week of pregnancy until the end. We assessed the risk of PPD using various standardized questionnaires, including the Edinburgh Postpartum Depression Scale, both before and about 1.5 months after the supplementation.

After the intervention, we saw notable improvements. The depression scores dropped significantly in the group receiving vitamin B6, contrasting with the control group, which showed no improvement. This suggests that vitamin B6 may indeed play a protective role against PPD in women at risk.

With our findings, we believe that vitamin B6 could be a valuable tool in the prevention of postpartum depression for high-risk mothers, offering a simple dietary option that may enhance mental well-being during a critical time.
Read More

Most Useful Reviews

9
Support for well-being
1 people found this helpful
After taking magnesium B6 for two months as my doctor prescribed, I decided to leave a review. This product is a solid alternative to pharmacy magnesium B6—better in terms of price and quantity. Magnesium is vital for the body's proper functioning, aiding blood vessel strength, normalising blood pressure, and improving muscle relaxation, which helped me overcome depression.
Read More
9
Life-changing benefits
1 people found this helpful
An effective vitamin and mineral complex that revitalised me! If you suffer from depression, hair loss, or insomnia, you may have a magnesium deficiency. It's unfortunate that doctors don’t always communicate such fundamental information to us!
Read More
9
Reduced stress levels
Magnesium-B6 helps reduce stress by promoting gamma-aminobutyric acid (GABA), beneficial for brain metabolism and the central nervous system. Magnesium also boosts melatonin production, which improves sleep and, since melatonin precedes serotonin, it enhances mood and aids in overcoming depression. Solgar's magnesium is the best; I highly recommend it!
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 28 Researches
7.5
  • All Researches
9.5
Magnesium and Vitamin D effective for depression
We explored the effectiveness of magnesium coupled with vitamin D in easing depressive symptoms among individuals with long-COVID. Our study involved 60 participants suffering from mild to moderate depression, hypomagnesemia, and vitamin D deficiency.

Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.

Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
Read More
9.5
Mental health influences gastric cancer
We explored the connections between mental health conditions, like depression and stress, and the risk of developing gastric cancer. In this study, we looked at 82 patients with gastric cancer compared to 95 healthy individuals, measuring their mental health using a Depression-Anxiety-Stress Scale. We also examined what they ate through a food frequency questionnaire that included 168 items.

Our findings showed a notable association between depression and stress with higher odds of gastric cancer. Notably, when we analyzed dietary factors in relation to depression, we found that vitamin B6 had a protective effect. Specifically, in individuals experiencing depression, higher levels of vitamin B6 correlated with a significantly lower likelihood of facing depressive symptoms.

While this points to vitamin B6's potential benefits, it’s important to note that it wasn't tested in isolation from other dietary influences. Therefore, while we observed promising links between vitamin B6 and improved mental health, the impact of a diverse diet as a whole cannot be overlooked. Future studies are essential to better understand the specific impacts of nutrients like vitamin B6 on mental health and, subsequently, on conditions like gastric cancer.
Read More
9
Magnesium intake reduces depression risk
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.

Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Read More
9
Vitamin B6 effectively battles depression
We explored the potential of vitamin B6 in treating depression, particularly how it compares to commonly used antidepressants. In our experiment, male mice were given a single dose of Bacillus-Calmette-Guerin (BCG) to induce depressive-like behaviors. Following this, we administered vitamin B6 alongside popular antidepressants such as fluoxetine, imipramine, and venlafaxine, to see how effectively each treatment mitigated symptoms over 14 days.

Our findings highlighted that vitamin B6 was effective in alleviating depression in the mice, just like the other antidepressant medications. The animals displayed significant improvements in both despair and anhedonia—key indicators of depression. Specifically, we noticed a decrease in immobility time during a forced swim test, indicating reduced despair. Plus, the latency to feed and food consumption improved significantly, showing that vitamin B6 helped counteract the depressive behaviors caused by BCG.

Overall, our research suggests that vitamin B6 can be a powerful ally in preventing depression, similar in effectiveness to some existing antidepressant drugs. We believe this opens the door for further clinical research on vitamin B6 as a potential treatment, especially for those at high risk for depression.
Read More
We conducted a study to explore how vitamin B6 affects postpartum depression (PPD) among mothers who are at risk. This clinical trial took place in Isfahan, Iran, with 81 pregnant women participating over several months in 2016.

Our approach involved a single-blind, placebo-controlled design, where 40 women received 80 mg of vitamin B6 while 41 others were given a placebo from the 28th week of pregnancy until the end. We assessed the risk of PPD using various standardized questionnaires, including the Edinburgh Postpartum Depression Scale, both before and about 1.5 months after the supplementation.

After the intervention, we saw notable improvements. The depression scores dropped significantly in the group receiving vitamin B6, contrasting with the control group, which showed no improvement. This suggests that vitamin B6 may indeed play a protective role against PPD in women at risk.

With our findings, we believe that vitamin B6 could be a valuable tool in the prevention of postpartum depression for high-risk mothers, offering a simple dietary option that may enhance mental well-being during a critical time.
Read More

User Reviews

USERS' SCORE
Good
Based on 8 Reviews
8.2
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Support for well-being
1 people found this helpful
After taking magnesium B6 for two months as my doctor prescribed, I decided to leave a review. This product is a solid alternative to pharmacy magnesium B6—better in terms of price and quantity. Magnesium is vital for the body's proper functioning, aiding blood vessel strength, normalising blood pressure, and improving muscle relaxation, which helped me overcome depression.
Read More
9
Life-changing benefits
1 people found this helpful
An effective vitamin and mineral complex that revitalised me! If you suffer from depression, hair loss, or insomnia, you may have a magnesium deficiency. It's unfortunate that doctors don’t always communicate such fundamental information to us!
Read More
9
Reduced stress levels
Magnesium-B6 helps reduce stress by promoting gamma-aminobutyric acid (GABA), beneficial for brain metabolism and the central nervous system. Magnesium also boosts melatonin production, which improves sleep and, since melatonin precedes serotonin, it enhances mood and aids in overcoming depression. Solgar's magnesium is the best; I highly recommend it!
Read More
9
Alleviated symptoms
I purchased this as it claimed to be effective for premenstrual syndrome. The magnesium seems to have caused some mild constipation, but it significantly alleviates my depression.
Read More
6
Effective for communication
3 people found this helpful
Magnesium is recommended. I consulted my doctor about my depression, and he suggested magnesium. I chose this product based on the reviews and took it with silicon to aid absorption. It is easy to swallow, and there are no issues with taking it. It's challenging to assess my mental improvement yet, but it seems to significantly enhance my communication. I used to experience frequent constipation, but now it's much less frequent, making me feel much better. As it was my first purchase, I will continue using it for now.
Read More

Frequently Asked Questions

9
Support for well-being
1 people found this helpful
After taking magnesium B6 for two months as my doctor prescribed, I decided to leave a review. This product is a solid alternative to pharmacy magnesium B6—better in terms of price and quantity. Magnesium is vital for the body's proper functioning, aiding blood vessel strength, normalising blood pressure, and improving muscle relaxation, which helped me overcome depression.
6
Effective for communication
3 people found this helpful
Magnesium is recommended. I consulted my doctor about my depression, and he suggested magnesium. I chose this product based on the reviews and took it with silicon to aid absorption. It is easy to swallow, and there are no issues with taking it. It's challenging to assess my mental improvement yet, but it seems to significantly enhance my communication. I used to experience frequent constipation, but now it's much less frequent, making me feel much better. As it was my first purchase, I will continue using it for now.
6
Promising results observed
1 people found this helpful
I bought this product as magnesium is beneficial for depression and insomnia. I've been taking it consistently, and it seems to help a bit with my depression. While I'm unsure if it's just a placebo effect, I believe it's a better option for what I might be lacking.
9
Reduced stress levels
Magnesium-B6 helps reduce stress by promoting gamma-aminobutyric acid (GABA), beneficial for brain metabolism and the central nervous system. Magnesium also boosts melatonin production, which improves sleep and, since melatonin precedes serotonin, it enhances mood and aids in overcoming depression. Solgar's magnesium is the best; I highly recommend it!
7.5
Relief from migraines
This magnesium from a well-respected brand, combined with vitamin B6, is essential for healthy body function, supporting bone health and emotional balance. The Mg B6 complex has proven beneficial for migraines, insomnia, and symptoms of depression. I regularly take up to 400mg without any side effects.
7.5
Useful supplement
1 people found this helpful
I took magnesium as part of my treatment for depression. It's beneficial to consume magnesium regularly, regardless of one's mental health. As we age, our body's need for magnesium increases due to its reduced absorption.
9
Magnesium intake reduces depression risk
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.

Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
8
Magnesium linked to lower depression risk
We examined how various nutrient patterns affect depressive symptoms in older adults through a detailed study involving over 1,000 participants.

By evaluating nutrient intake and depressive symptoms over more than 15 years, we found that those with a diet high in magnesium and several other nutrients had significantly lower odds of experiencing depressive symptoms.

This suggests that nutrients, particularly magnesium, might play a crucial role in supporting mental health in older adults.
9.5
Magnesium and Vitamin D effective for depression
We explored the effectiveness of magnesium coupled with vitamin D in easing depressive symptoms among individuals with long-COVID. Our study involved 60 participants suffering from mild to moderate depression, hypomagnesemia, and vitamin D deficiency.

Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.

Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.

References

  1. Serefko A, Lachowicz-Radulska J, Szopa A, Herbet M, Czylkowska A, et al. The Novel Imipramine-Magnesium Complex Exerts Antidepressant-like Activity in Mice Subjected to the Forced Swim Test and the Tail Suspension Test. Molecules. 2025;30. doi:10.3390/molecules30030519
  2. Bardinet J, Pouchieu C, Chuy V, Merle B, Pellay H, et al. Association between nutrient patterns and odds of depressive symptomatology: a population-based cohort of older adults followed during 15-y. Eur J Nutr. 2025;64:88. doi:10.1007/s00394-025-03597-x
  3. Rodríguez-Morán M, Guerrero-Romero F, Barragán-Zuñiga J, Gamboa-Gómez CI, Weyman-Vela Y, et al. Combined oral supplementation with magnesium plus vitamin D alleviates mild to moderate depressive symptoms related to long-COVID: an open-label randomized, controlled clinical trial. Magnes Res. 2024;37:49. doi:10.1684/mrh.2024.0535
  4. Zhao W, Jin H. Magnesium depletion score and depression: a positive correlation among US adults. Front Public Health. 2024;12:1486434. doi:10.3389/fpubh.2024.1486434
  5. Carnegie RE, Zheng J, Borges MC, Jones HJ, Wade KH, et al. Micronutrients and Major Depression: A Mendelian Randomisation Study. Nutrients. 2024;16. doi:10.3390/nu16213690
  6. Cai Z, She J, Liu X, Li R, Guo S, et al. Associations between magnesium depletion score and depression among individuals aged 20 to 60 years. J Trace Elem Med Biol. 2024;86:127543. doi:10.1016/j.jtemb.2024.127543
  7. Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. doi:10.1038/s41598-024-71093-z
  8. Hajhashemy Z, Shirani F, Askari G. Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. Nutr Rev. 2025;83:217. doi:10.1093/nutrit/nuae056
  9. Abdelmoneam AH, Khafagy GM, Elbeh KA, Hasan MDA. Impact of Magnesium and Ferritin Deficiency on Depression Among Adolescent Students. J Prim Care Community Health. 2024;15:21501319241252570. doi:10.1177/21501319241252570
  10. Chou MH, Yang YK, Wang JD, Lin CY, Lin SH. Elevated C-Reactive Protein Levels Modify the Effect of Magnesium on Depressive Symptoms: A Population-Based Study. Nutrients. 2023;15. doi:10.3390/nu15071560
  11. Chou MH, Yang YK, Wang JD, Lin CY, Lin SH. The Association of Serum and Dietary Magnesium with Depressive Symptoms. Nutrients. 2023;15. doi:10.3390/nu15030774
  12. Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y
  13. Wang H, Jin M, Xie M, Yang Y, Xue F, et al. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials. J Affect Disord. 2023;323:264. doi:10.1016/j.jad.2022.11.072
  14. Saba S, Faizi F, Sepandi M, Nehrir B. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery. Magnes Res. 2022;35:62. doi:10.1684/mrh.2022.0503
  15. Abiri B, Sarbakhsh P, Vafa M. Randomized study of the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms. Nutr Neurosci. 2022;25:2123. doi:10.1080/1028415X.2021.1945859
  16. Miller ES, Sakowicz A, Roy A, Wang A, Yang A, et al. Is peripartum magnesium sulfate associated with a reduction in postpartum depressive symptoms?. Am J Obstet Gynecol MFM. 2021;3:100407. doi:10.1016/j.ajogmf.2021.100407
  17. Lu J, Mao H, Tan Y, Luo G. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010. Brain Behav. 2024;14:e70128. doi:10.1002/brb3.70128
  18. Rajasekar R, VanderMolen J, Barnhart K, Anguilim N. Dietary intake with supplementation of vitamin D, vitamin B6, and magnesium on depressive symptoms: a public health perspective. Front Public Health. 2024;12:1369666. doi:10.3389/fpubh.2024.1369666
  19. Vahid F, Rahmani W, Davoodi SH, Bohn T. Mental Health Conditions, Including Depression and Stress, Are Associated with Increased Odds of Gastric Cancer-Insights into the Role of Diet: A Case-Control Study. Nutrients. 2023;15. doi:10.3390/nu15234981
  20. Lagzi N, Bateni A, Goli R, Talebiazar N. The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. Int J Psychiatry Med. 2023;58:576. doi:10.1177/00912174231179320
  21. Mesripour A, Golchin S. Vitamin B6 Antidepressant Effects Are Comparable to Common Antidepressant Drugs in Bacillus-Calmette-Guerin Induced Depression Model in Mice. Iran J Psychiatry. 2022;17:208. doi:10.18502/ijps.v17i2.8911
  22. Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37:e2852. doi:10.1002/hup.2852
  23. Noah L, Morel V, Bertin C, Pouteau E, Macian N, et al. Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled Study. Nutrients. 2022;14. doi:10.3390/nu14091863
  24. C Curtin A, Johnston CS. Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial. J Diet Suppl. 2023;20:550. doi:10.1080/19390211.2022.2030843
  25. Khodadad M, Bahadoran P, Kheirabadi GR, Sabzghabaee AM. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial. Int J Prev Med. 2021;12:136. doi:10.4103/ijpvm.IJPVM_240_19
  26. Maratha S, Sharma V, Walia V. Possible involvement of NO-sGC-cGMP signaling in the antidepressant like effect of pyridoxine in mice. Metab Brain Dis. 2022;37:173. doi:10.1007/s11011-021-00858-6
  27. Ferriani LO, Silva DA, Molina MDCB, Mill JG, Brunoni AR, et al. Associations of depression and intake of antioxidants and vitamin B complex: Results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). J Affect Disord. 2022;297:259. doi:10.1016/j.jad.2021.10.027
  28. Wu Y, Li S, Wang W, Zhang D. Associations of dietary B vitamins intakes with depression in adults. Int J Vitam Nutr Res. 2023;93:142. doi:10.1024/0300-9831/a000720
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