Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies.
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Read More
9
Vitamin B6 effectively battles depression
Vitamin B6 Antidepressant Effects Are Comparable to Common Antidepressant Drugs in Bacillus-Calmette-Guerin Induced Depression Model in Mice.
We explored the potential of vitamin B6 in treating depression, particularly how it compares to commonly used antidepressants. In our experiment, male mice were given a single dose of Bacillus-Calmette-Guerin (BCG) to induce depressive-like behaviors. Following this, we administered vitamin B6 alongside popular antidepressants such as fluoxetine, imipramine, and venlafaxine, to see how effectively each treatment mitigated symptoms over 14 days.
Our findings highlighted that vitamin B6 was effective in alleviating depression in the mice, just like the other antidepressant medications. The animals displayed significant improvements in both despair and anhedonia—key indicators of depression. Specifically, we noticed a decrease in immobility time during a forced swim test, indicating reduced despair. Plus, the latency to feed and food consumption improved significantly, showing that vitamin B6 helped counteract the depressive behaviors caused by BCG.
Overall, our research suggests that vitamin B6 can be a powerful ally in preventing depression, similar in effectiveness to some existing antidepressant drugs. We believe this opens the door for further clinical research on vitamin B6 as a potential treatment, especially for those at high risk for depression.
Read More
9
Vitamin B6 helps prevent PPD
Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
We conducted a study to explore how vitamin B6 affects postpartum depression (PPD) among mothers who are at risk. This clinical trial took place in Isfahan, Iran, with 81 pregnant women participating over several months in 2016.
Our approach involved a single-blind, placebo-controlled design, where 40 women received 80 mg of vitamin B6 while 41 others were given a placebo from the 28th week of pregnancy until the end. We assessed the risk of PPD using various standardized questionnaires, including the Edinburgh Postpartum Depression Scale, both before and about 1.5 months after the supplementation.
After the intervention, we saw notable improvements. The depression scores dropped significantly in the group receiving vitamin B6, contrasting with the control group, which showed no improvement. This suggests that vitamin B6 may indeed play a protective role against PPD in women at risk.
With our findings, we believe that vitamin B6 could be a valuable tool in the prevention of postpartum depression for high-risk mothers, offering a simple dietary option that may enhance mental well-being during a critical time.
Read More
Most Useful Reviews
9
Support for well-being
1 people found this helpful
After taking magnesium B6 for two months as my doctor prescribed, I decided to leave a review. This product is a solid alternative to pharmacy magnesium B6—better in terms of price and quantity. Magnesium is vital for the body's proper functioning, aiding blood vessel strength, normalising blood pressure, and improving muscle relaxation, which helped me overcome depression.
Read More
9
Life-changing benefits
1 people found this helpful
An effective vitamin and mineral complex that revitalised me! If you suffer from depression, hair loss, or insomnia, you may have a magnesium deficiency. It's unfortunate that doctors don’t always communicate such fundamental information to us!
Read More
9
Reduced stress levels
Magnesium-B6 helps reduce stress by promoting gamma-aminobutyric acid (GABA), beneficial for brain metabolism and the central nervous system. Magnesium also boosts melatonin production, which improves sleep and, since melatonin precedes serotonin, it enhances mood and aids in overcoming depression. Solgar's magnesium is the best; I highly recommend it!
Combined oral supplementation with magnesium plus vitamin D alleviates mild to moderate depressive symptoms related to long-COVID: an open-label randomized, controlled clinical trial.
We explored the effectiveness of magnesium coupled with vitamin D in easing depressive symptoms among individuals with long-COVID. Our study involved 60 participants suffering from mild to moderate depression, hypomagnesemia, and vitamin D deficiency.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
Read More
9.5
Mental health influences gastric cancer
Mental Health Conditions, Including Depression and Stress, Are Associated with Increased Odds of Gastric Cancer-Insights into the Role of Diet: A Case-Control Study.
We explored the connections between mental health conditions, like depression and stress, and the risk of developing gastric cancer. In this study, we looked at 82 patients with gastric cancer compared to 95 healthy individuals, measuring their mental health using a Depression-Anxiety-Stress Scale. We also examined what they ate through a food frequency questionnaire that included 168 items.
Our findings showed a notable association between depression and stress with higher odds of gastric cancer. Notably, when we analyzed dietary factors in relation to depression, we found that vitamin B6 had a protective effect. Specifically, in individuals experiencing depression, higher levels of vitamin B6 correlated with a significantly lower likelihood of facing depressive symptoms.
While this points to vitamin B6's potential benefits, it’s important to note that it wasn't tested in isolation from other dietary influences. Therefore, while we observed promising links between vitamin B6 and improved mental health, the impact of a diverse diet as a whole cannot be overlooked. Future studies are essential to better understand the specific impacts of nutrients like vitamin B6 on mental health and, subsequently, on conditions like gastric cancer.
Read More
9
Magnesium intake reduces depression risk
Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies.
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
Read More
9
Vitamin B6 effectively battles depression
Vitamin B6 Antidepressant Effects Are Comparable to Common Antidepressant Drugs in Bacillus-Calmette-Guerin Induced Depression Model in Mice.
We explored the potential of vitamin B6 in treating depression, particularly how it compares to commonly used antidepressants. In our experiment, male mice were given a single dose of Bacillus-Calmette-Guerin (BCG) to induce depressive-like behaviors. Following this, we administered vitamin B6 alongside popular antidepressants such as fluoxetine, imipramine, and venlafaxine, to see how effectively each treatment mitigated symptoms over 14 days.
Our findings highlighted that vitamin B6 was effective in alleviating depression in the mice, just like the other antidepressant medications. The animals displayed significant improvements in both despair and anhedonia—key indicators of depression. Specifically, we noticed a decrease in immobility time during a forced swim test, indicating reduced despair. Plus, the latency to feed and food consumption improved significantly, showing that vitamin B6 helped counteract the depressive behaviors caused by BCG.
Overall, our research suggests that vitamin B6 can be a powerful ally in preventing depression, similar in effectiveness to some existing antidepressant drugs. We believe this opens the door for further clinical research on vitamin B6 as a potential treatment, especially for those at high risk for depression.
Read More
9
Vitamin B6 helps prevent PPD
Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial.
We conducted a study to explore how vitamin B6 affects postpartum depression (PPD) among mothers who are at risk. This clinical trial took place in Isfahan, Iran, with 81 pregnant women participating over several months in 2016.
Our approach involved a single-blind, placebo-controlled design, where 40 women received 80 mg of vitamin B6 while 41 others were given a placebo from the 28th week of pregnancy until the end. We assessed the risk of PPD using various standardized questionnaires, including the Edinburgh Postpartum Depression Scale, both before and about 1.5 months after the supplementation.
After the intervention, we saw notable improvements. The depression scores dropped significantly in the group receiving vitamin B6, contrasting with the control group, which showed no improvement. This suggests that vitamin B6 may indeed play a protective role against PPD in women at risk.
With our findings, we believe that vitamin B6 could be a valuable tool in the prevention of postpartum depression for high-risk mothers, offering a simple dietary option that may enhance mental well-being during a critical time.
After taking magnesium B6 for two months as my doctor prescribed, I decided to leave a review. This product is a solid alternative to pharmacy magnesium B6—better in terms of price and quantity. Magnesium is vital for the body's proper functioning, aiding blood vessel strength, normalising blood pressure, and improving muscle relaxation, which helped me overcome depression.
Read More
9
Life-changing benefits
1 people found this helpful
An effective vitamin and mineral complex that revitalised me! If you suffer from depression, hair loss, or insomnia, you may have a magnesium deficiency. It's unfortunate that doctors don’t always communicate such fundamental information to us!
Read More
9
Reduced stress levels
Magnesium-B6 helps reduce stress by promoting gamma-aminobutyric acid (GABA), beneficial for brain metabolism and the central nervous system. Magnesium also boosts melatonin production, which improves sleep and, since melatonin precedes serotonin, it enhances mood and aids in overcoming depression. Solgar's magnesium is the best; I highly recommend it!
Read More
9
Alleviated symptoms
I purchased this as it claimed to be effective for premenstrual syndrome. The magnesium seems to have caused some mild constipation, but it significantly alleviates my depression.
Read More
6
Effective for communication
3 people found this helpful
Magnesium is recommended. I consulted my doctor about my depression, and he suggested magnesium. I chose this product based on the reviews and took it with silicon to aid absorption. It is easy to swallow, and there are no issues with taking it. It's challenging to assess my mental improvement yet, but it seems to significantly enhance my communication. I used to experience frequent constipation, but now it's much less frequent, making me feel much better. As it was my first purchase, I will continue using it for now.
Depression is a common and serious mental health condition characterized by persistent feelings of sadness, hopelessness, and a lack of interest or pleasure in activities that were once enjoyable. It can affect anyone, regardless of age, gender, or background, and it goes beyond just feeling down; it can interfere significantly with daily life, impacting relationships, work performance, and overall well-being. Symptoms of depression may include changes in appetite or weight, sleep disturbances, fatigue, difficulty concentrating, and thoughts of worthlessness or suicide.
The causes of depression are complex and may involve a combination of genetic, biological, environmental, and psychological factors. While it's a serious condition that can be debilitating, the good news is that it is treatable. Various treatment options are available, including therapy, medication, lifestyle changes, and support groups. If you or someone you know is struggling with depression, seeking help from a healthcare professional is a crucial step toward recovery.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Recent research suggests that magnesium may play a role in managing symptoms of depression, though the exact mechanisms are not fully understood. Magnesium is essential for numerous biochemical processes in the body, including neurotransmitter function and hormonal regulation. Some studies have indicated that low magnesium levels are associated with a higher incidence of depression and that supplementation might improve mood and reduce anxiety in some individuals. However, it is important to note that while magnesium could potentially support mental health, it should not replace conventional treatments like therapy or medication, especially for severe depression.
If you're considering magnesium supplementation as a part of your wellness routine, it’s always wise to consult with a healthcare professional. They can help you assess your specific needs, including dietary intake and any potential interactions with medications you may be taking. In addition, magnesium can be found in various dietary sources like leafy greens, nuts, seeds, and whole grains, which can contribute to a holistic approach to mental health. Overall, while magnesium may offer some benefits, it should be viewed as a complementary option rather than a primary treatment strategy for depression.
Based on user reviews, the timeline for seeing results from magnesium B6 supplements for depression can vary among individuals. Some users report feeling significant improvements in their symptoms after a month or two of consistent use. For instance, one reviewer mentioned they began to notice a positive impact after two months of taking magnesium B6 as prescribed by their doctor, emphasizing its effectiveness in helping them overcome depression Read Review. Another user shared that while they found it challenging to assess their mental improvement, they noticed improvements in communication and overall well-being after starting the supplement Read Review.
Other reviews suggest that consistent intake of magnesium B6 can aid in alleviating symptoms associated with depression, although some users caution that the effects may take time to manifest fully. For instance, one user remarked that while they were uncertain if their improvements were due to the supplement or a placebo effect, they still felt it was beneficial Read Review. Overall, while some experience relief relatively quickly, it appears that a consistent regimen lasting several weeks is often necessary to gauge its true effectiveness.
Recent research indicates that magnesium may play a significant role in alleviating depression symptoms. Numerous studies have shown a strong correlation between magnesium intake and reduced depressive symptoms. For instance, a systematic review and meta-analysis involving over 63,000 individuals found that higher dietary magnesium intake was associated with a 34% lower chance of experiencing depression ([8]). Additionally, a study focusing on older adults demonstrated that those with diets rich in magnesium had significantly lower odds of exhibiting depressive symptoms ([2]).
Further supporting this, investigations into magnesium supplementation have shown promising results for individuals suffering from depression related to various conditions, including long-COVID. In one study, participants receiving magnesium along with vitamin D reported significant improvements in their depression scores compared to those receiving only vitamin D ([3]). The evidence suggests that maintaining adequate magnesium levels might not only prevent depression but also enhance treatment outcomes for those already affected. Given these findings, magnesium supplementation could be considered a valuable addition to depression management strategies.
Based on user reviews, many individuals have reported various improvements in their symptoms related to depression after taking magnesium B6 supplements. A user noted a significant change after two months of use, describing how the supplement helped them overcome depression through essential functions like muscle relaxation and blood pressure normalization Read Review. Another reviewer highlighted that magnesium B6 aids in reducing stress and improves sleep quality, which in turn enhances mood and alleviates depressive symptoms Read Review.
Furthermore, users have also reported ancillary benefits, such as improved communication and reduced constipation—issues previously exacerbated by their mental health struggles Read Review. While some caution that the perceived improvements could be due to a placebo effect, the consensus remains that magnesium B6 may be a beneficial addition to mental health management, although individual results do vary Read Review. Overall, many users recommend magnesium B6 for its potential to support emotional balance and improve symptoms associated with depression.
Based on user reviews, the combination of magnesium B6 with other supplements seems to yield positive feedback for managing depression. Users have reported that taking magnesium, particularly in conjunction with vitamin B6, has enhanced its benefits. One reviewer emphasized that magnesium B6 helps to boost melatonin production, which subsequently improves mood and aids in overcoming depression Read Review. Another user mentioned that they took magnesium alongside silicon to aid absorption, and while assessing mental improvements was challenging, they did notice enhancements in communication and a decrease in constipation, which are often hindered by their mental health struggles Read Review.
Moreover, some users have noted the safety and efficacy of regular magnesium intake for emotional balance and depression management. One reviewer shared that they had no side effects while taking up to 400mg daily, highlighting the dual benefits for not only emotional health but also physical well-being Read Review. Overall, it appears that combining magnesium B6 with other supplements can create a synergistic effect, offering support for those dealing with depressive symptoms.
Based on user reviews, there appears to be a consensus regarding the effectiveness of magnesium for treating depression, although the specific dosage varies among user experiences. One user, who took magnesium with vitamin B6, reported a significant improvement in their depression symptoms after following their doctor's advice, indicating that they took an undetermined but likely standard dosage over two months Read Review. Another user noted regularly taking up to 400mg of magnesium without side effects, suggesting this may be an effective upper limit for others considering magnesium for mental health Read Review.
Several users described positive changes in their mood linked to magnesium supplementation, though some expressed uncertainty about the exact dosage effectiveness. While some users emphasized the importance of consulting a doctor before starting magnesium supplements, there’s a general recommendation that magnesium intake should be a consistent aspect of one’s routine, particularly as dietary absorption decreases with age Read Review. Additionally, the combination of magnesium with vitamin B6 was highlighted as beneficial, as it reportedly enhanced mood and improved overall emotional balance Read Review. Overall, users suggest that while individual responses may vary, magnesium could potentially play a vital role in managing depression symptoms.
9
Support for well-being
1 people found this helpful
After taking magnesium B6 for two months as my doctor prescribed, I decided to leave a review. This product is a solid alternative to pharmacy magnesium B6—better in terms of price and quantity. Magnesium is vital for the body's proper functioning, aiding blood vessel strength, normalising blood pressure, and improving muscle relaxation, which helped me overcome depression.
6
Effective for communication
3 people found this helpful
Magnesium is recommended. I consulted my doctor about my depression, and he suggested magnesium. I chose this product based on the reviews and took it with silicon to aid absorption. It is easy to swallow, and there are no issues with taking it. It's challenging to assess my mental improvement yet, but it seems to significantly enhance my communication. I used to experience frequent constipation, but now it's much less frequent, making me feel much better. As it was my first purchase, I will continue using it for now.
6
Promising results observed
1 people found this helpful
I bought this product as magnesium is beneficial for depression and insomnia. I've been taking it consistently, and it seems to help a bit with my depression. While I'm unsure if it's just a placebo effect, I believe it's a better option for what I might be lacking.
9
Reduced stress levels
Magnesium-B6 helps reduce stress by promoting gamma-aminobutyric acid (GABA), beneficial for brain metabolism and the central nervous system. Magnesium also boosts melatonin production, which improves sleep and, since melatonin precedes serotonin, it enhances mood and aids in overcoming depression. Solgar's magnesium is the best; I highly recommend it!
7.5
Relief from migraines
This magnesium from a well-respected brand, combined with vitamin B6, is essential for healthy body function, supporting bone health and emotional balance. The Mg B6 complex has proven beneficial for migraines, insomnia, and symptoms of depression. I regularly take up to 400mg without any side effects.
7.5
Useful supplement
1 people found this helpful
I took magnesium as part of my treatment for depression. It's beneficial to consume magnesium regularly, regardless of one's mental health. As we age, our body's need for magnesium increases due to its reduced absorption.
9
Magnesium intake reduces depression risk
Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies.
We conducted a systematic review and meta-analysis exploring how dietary magnesium (Mg) intake connects with depression among adults. By reviewing data from over 63,000 individuals, we found that those with the highest magnesium intake had a 34% lower chance of experiencing depression compared to those with the lowest intake.
Furthermore, our analysis indicated that every increase of 100 mg per day in magnesium intake was linked to a 7% reduced risk of depression. These findings suggest that increasing dietary magnesium could play a valuable role in lowering depression risk.
8
Magnesium linked to lower depression risk
Association between nutrient patterns and odds of depressive symptomatology: a population-based cohort of older adults followed during 15-y.
We examined how various nutrient patterns affect depressive symptoms in older adults through a detailed study involving over 1,000 participants.
By evaluating nutrient intake and depressive symptoms over more than 15 years, we found that those with a diet high in magnesium and several other nutrients had significantly lower odds of experiencing depressive symptoms.
This suggests that nutrients, particularly magnesium, might play a crucial role in supporting mental health in older adults.
9.5
Magnesium and Vitamin D effective for depression
Combined oral supplementation with magnesium plus vitamin D alleviates mild to moderate depressive symptoms related to long-COVID: an open-label randomized, controlled clinical trial.
We explored the effectiveness of magnesium coupled with vitamin D in easing depressive symptoms among individuals with long-COVID. Our study involved 60 participants suffering from mild to moderate depression, hypomagnesemia, and vitamin D deficiency.
Over four months, those who received both magnesium and vitamin D showed significant improvements in their depression scores compared to those who only took vitamin D. Specifically, a notable 73% of the magnesium group achieved significant relief, positioning this combination as a promising treatment for depression linked to long-COVID.
Mild side effects were noted but did not lead to any withdrawals, indicating the safety of this treatment option.
References
Serefko A, Lachowicz-Radulska J, Szopa A, Herbet M, Czylkowska A, et al. The Novel Imipramine-Magnesium Complex Exerts Antidepressant-like Activity in Mice Subjected to the Forced Swim Test and the Tail Suspension Test. Molecules. 2025;30. doi:10.3390/molecules30030519
Bardinet J, Pouchieu C, Chuy V, Merle B, Pellay H, et al. Association between nutrient patterns and odds of depressive symptomatology: a population-based cohort of older adults followed during 15-y. Eur J Nutr. 2025;64:88. doi:10.1007/s00394-025-03597-x
Rodríguez-Morán M, Guerrero-Romero F, Barragán-Zuñiga J, Gamboa-Gómez CI, Weyman-Vela Y, et al. Combined oral supplementation with magnesium plus vitamin D alleviates mild to moderate depressive symptoms related to long-COVID: an open-label randomized, controlled clinical trial. Magnes Res. 2024;37:49. doi:10.1684/mrh.2024.0535
Zhao W, Jin H. Magnesium depletion score and depression: a positive correlation among US adults. Front Public Health. 2024;12:1486434. doi:10.3389/fpubh.2024.1486434
Carnegie RE, Zheng J, Borges MC, Jones HJ, Wade KH, et al. Micronutrients and Major Depression: A Mendelian Randomisation Study. Nutrients. 2024;16. doi:10.3390/nu16213690
Cai Z, She J, Liu X, Li R, Guo S, et al. Associations between magnesium depletion score and depression among individuals aged 20 to 60 years. J Trace Elem Med Biol. 2024;86:127543. doi:10.1016/j.jtemb.2024.127543
Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. doi:10.1038/s41598-024-71093-z
Hajhashemy Z, Shirani F, Askari G. Dietary Magnesium Intake in Relation to Depression in Adults: A GRADE-Assessed Systematic Review and Dose-Response Meta-analysis of Epidemiologic Studies. Nutr Rev. 2025;83:217. doi:10.1093/nutrit/nuae056
Abdelmoneam AH, Khafagy GM, Elbeh KA, Hasan MDA. Impact of Magnesium and Ferritin Deficiency on Depression Among Adolescent Students. J Prim Care Community Health. 2024;15:21501319241252570. doi:10.1177/21501319241252570
Chou MH, Yang YK, Wang JD, Lin CY, Lin SH. Elevated C-Reactive Protein Levels Modify the Effect of Magnesium on Depressive Symptoms: A Population-Based Study. Nutrients. 2023;15. doi:10.3390/nu15071560
Chou MH, Yang YK, Wang JD, Lin CY, Lin SH. The Association of Serum and Dietary Magnesium with Depressive Symptoms. Nutrients. 2023;15. doi:10.3390/nu15030774
Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. doi:10.1186/s12974-023-02696-y
Wang H, Jin M, Xie M, Yang Y, Xue F, et al. Protective role of antioxidant supplementation for depression and anxiety: A meta-analysis of randomized clinical trials. J Affect Disord. 2023;323:264. doi:10.1016/j.jad.2022.11.072
Saba S, Faizi F, Sepandi M, Nehrir B. Effect of short-term magnesium supplementation on anxiety, depression and sleep quality in patients after open-heart surgery. Magnes Res. 2022;35:62. doi:10.1684/mrh.2022.0503
Abiri B, Sarbakhsh P, Vafa M. Randomized study of the effects of vitamin D and/or magnesium supplementation on mood, serum levels of BDNF, inflammation, and SIRT1 in obese women with mild to moderate depressive symptoms. Nutr Neurosci. 2022;25:2123. doi:10.1080/1028415X.2021.1945859
Miller ES, Sakowicz A, Roy A, Wang A, Yang A, et al. Is peripartum magnesium sulfate associated with a reduction in postpartum depressive symptoms?. Am J Obstet Gynecol MFM. 2021;3:100407. doi:10.1016/j.ajogmf.2021.100407
Lu J, Mao H, Tan Y, Luo G. Associations of Dietary Intake of Vitamin B6 and Plasma Pyridoxal 5'-Phosphate Level With Depression in US Adults: Findings From NHANES 2005-2010. Brain Behav. 2024;14:e70128. doi:10.1002/brb3.70128
Rajasekar R, VanderMolen J, Barnhart K, Anguilim N. Dietary intake with supplementation of vitamin D, vitamin B6, and magnesium on depressive symptoms: a public health perspective. Front Public Health. 2024;12:1369666. doi:10.3389/fpubh.2024.1369666
Vahid F, Rahmani W, Davoodi SH, Bohn T. Mental Health Conditions, Including Depression and Stress, Are Associated with Increased Odds of Gastric Cancer-Insights into the Role of Diet: A Case-Control Study. Nutrients. 2023;15. doi:10.3390/nu15234981
Lagzi N, Bateni A, Goli R, Talebiazar N. The effect of multivitamins on anxiety and depression in patients undergoing methadone maintenance treatment: A double-blind randomized controlled trial. Int J Psychiatry Med. 2023;58:576. doi:10.1177/00912174231179320
Mesripour A, Golchin S. Vitamin B6 Antidepressant Effects Are Comparable to Common Antidepressant Drugs in Bacillus-Calmette-Guerin Induced Depression Model in Mice. Iran J Psychiatry. 2022;17:208. doi:10.18502/ijps.v17i2.8911
Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37:e2852. doi:10.1002/hup.2852
Noah L, Morel V, Bertin C, Pouteau E, Macian N, et al. Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled Study. Nutrients. 2022;14. doi:10.3390/nu14091863
C Curtin A, Johnston CS. Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial. J Diet Suppl. 2023;20:550. doi:10.1080/19390211.2022.2030843
Khodadad M, Bahadoran P, Kheirabadi GR, Sabzghabaee AM. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial. Int J Prev Med. 2021;12:136. doi:10.4103/ijpvm.IJPVM_240_19
Maratha S, Sharma V, Walia V. Possible involvement of NO-sGC-cGMP signaling in the antidepressant like effect of pyridoxine in mice. Metab Brain Dis. 2022;37:173. doi:10.1007/s11011-021-00858-6
Ferriani LO, Silva DA, Molina MDCB, Mill JG, Brunoni AR, et al. Associations of depression and intake of antioxidants and vitamin B complex: Results of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). J Affect Disord. 2022;297:259. doi:10.1016/j.jad.2021.10.027
Wu Y, Li S, Wang W, Zhang D. Associations of dietary B vitamins intakes with depression in adults. Int J Vitam Nutr Res. 2023;93:142. doi:10.1024/0300-9831/a000720