Solgar Methylcobalamin 1000 mcg

We assessed the effect of vitamin B12 supplementation on depressive symptoms by reviewing several randomized controlled trials (RCTs). Our analysis focused on participants who may experience mild cognitive impairment, an area where low vitamin B12 levels could potentially raise the risk of depression.

After a thorough examination of studies, we found that the included trials did not support a significant benefit of vitamin B12 for alleviating depressive symptoms. In our evaluation of three studies focusing specifically on depression, the average difference in symptoms was negligible, indicating no real effect.

This outcome reflects that while vitamin B12 is essential for various bodily functions, its role in improving mood and reducing depression symptoms may not be as effective as some might hope. Further exploration is still warranted to better understand the contexts in which vitamin B12 could be beneficial.

Depression alleviated

Most Useful Review

A beautiful product! To be brief, my depression has passed, and I have experienced less hair loss.

Anxiety details

SCIENTIFIC SCORE

Questionable

Based on 4 Researches

Vitamin B12 may reduce anxiety

Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach.

Most Relevant Research

We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.

The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.

Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.

9.5

Calming effect before bed

Most Useful Review

Great mood enhancer! I read that B12 helps with anxiety and bought this recently. It works remarkably well; I usually take it at night, which calms me down before bedtime.

Migraine details

SCIENTIFIC SCORE

Questionable

Based on 11 Researches

Vitamin B12 deficiency and migraines

The correlation between vitamin B12 serum levels and migraine: a case-control study.

Most Relevant Research

We examined the connection between vitamin B12 serum levels and migraine, both chronic and episodic. In our study, we compared two groups: 90 individuals suffering from migraines and 90 healthy participants. We measured the serum vitamin B12 levels of all subjects using a method known as enzyme-linked immunosorbent assay (ELISA).

Our findings showed that those with migraines had notably lower levels of vitamin B12 compared to the healthy control group. Specifically, chronic migraine patients had even lower serum vitamin B12 levels than those with episodic migraines. Additionally, we found a significant negative link between lower vitamin B12 levels and the severity of migraine attacks.

This indicates that individuals with vitamin B12 deficiency may experience more severe migraine symptoms. The results suggest a strong association between low vitamin B12 levels and migraines, pointing to a potential area for further research. We believe that exploring this relationship through interventional studies could offer valuable insights into migraine treatments.

Quick migraine relief

Most Useful Review

Since starting with this brand of B12, I feel fabulous. Occasionally, I notice it takes longer to work when I use it for migraine relief, but I can tell a difference in how I feel overall.

Shingles details

SCIENTIFIC SCORE

Moderately Effective

Based on 7 Researches

Vitamin B12 aids shingles pain relief

Vitamin B12 for herpetic neuralgia: A meta-analysis of randomised controlled trials.

Most Relevant Research

We conducted a review of randomized controlled trials to determine the effectiveness of vitamin B12 in treating postherpetic neuralgia (PHN), a painful condition following shingles. Our analysis included data from databases such as PubMed and Cochrane Library, focusing specifically on trials that measured pain relief outcomes.

Our findings indicate that vitamin B12 supplementation has a significant positive effect on reducing pain levels in PHN patients. In fact, those who received vitamin B12 experienced a notable decrease in pain compared to those on placebo, with a reduction in the pain score of about four points. This result suggests that vitamin B12 not only helps with pain relief but also enhances overall quality of life for individuals suffering from this distressing condition.

Additionally, we observed a drop in the number of patients relying on analgesics, pointing to a potential alternative treatment avenue with vitamin B12. Although the evidence is moderate in quality, it presents a compelling case for the use of vitamin B12 as a complementary therapy for managing pain associated with shingles.

Calmed nerve issues

Most Useful Review

This product significantly helped me with shingles recently! When combined with L-Lysine, it calmed the nerve issues associated with shingles remarkably well.

Cold details

SCIENTIFIC SCORE

Possibly Effective

Based on 2 Researches

Vitamin B12 shows cold pain relief

The effects of vitamin B12 and diclofenac and their combination on cold and mechanical allodynia in a neuropathic pain model in rats.

Most Relevant Research

We explored the potential effects of vitamin B12 on cold sensitivity in a study using rats with induced neuropathic pain. The focus was to see whether vitamin B12, both alone and in combination with the pain reliever diclofenac, could alleviate cold and mechanical allodynia—a condition where non-painful stimuli are perceived as painful.

In our approach, we administered vitamin B12 in varying doses over ten consecutive days following nerve injury. What we discovered was quite telling. Higher doses of vitamin B12 (50, 100, and 200 µg kg(-1)) led to a reduction in cold sensitivity. However, when using a lower, subanalgesic dose (25 µg kg(-1)), vitamin B12 did not significantly impact pain responses when paired with low doses of diclofenac.

As we adjusted the vitamin B12 dosage to a more effective level (100 µg kg(-1)), we noticed an improvement in pain relief compared to diclofenac alone. These findings suggest that vitamin B12 could have a positive effect on alleviating cold-related pain in neuropathic conditions, especially when used at appropriate doses.

7.5

Improves circulation

Most Useful Review

I laughed when I opened the bottle to find such tiny tablets at the bottom—what a waste of packaging! However, the supplement quality seems good. The mild, cherry flavour is agreeable, and it dissolves easily under my tongue. I didn’t feel an immediate energy boost but noticed a difference in my circulation after two weeks. My previously cold toes have improved significantly.

Reflux details

B-12 absorption problem

Most Useful Review

This product has effectively kept my low B-12 jitters and memory fog at bay. Acid controllers for heartburn or reflux hinder B-12 absorption, but this sublingual tablet allows for better absorption. Since beginning treatment, my symptoms have disappeared. I'm now more energised and my overall mood has improved.