' 
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
USERS' SCORE
Good
Based on 10 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3
25 mcg (1,000 IU)
125%
Top Medical Research Studies
8
Vitamin D3 offers anti-cancer benefits
Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.
Study emphasizes isolated effects
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Read More
9
Vitamin D3 derivatives improve cancer treatment
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Highly relevant to cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
8
Vitamin D's potential in CRC
Exploration and Identification of Vitamin D and Related Genes as Potential Biomarkers for Colorectal Tumors.
High relevance to cancer treatment
We delved into the intriguing relationship between vitamin D and colorectal cancer (CRC) to uncover how this nutrient might influence cancer development and treatment. The study involved measuring the serum levels of active vitamin D (1,25(OH)D) in different groups, including those with normal conditions, colorectal adenomas (CRA), and colorectal cancer (CRC).
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Read More
Most Useful Reviews
9.5
Effective for bone density
This product is great! It's easy to swallow and has no aftertaste. Due to lower bone density from radiation treatment for cancer, I take these alongside calcium supplements, ensuring my Vitamin D intake stays healthy.
Read More
9.5
Stronger immunity
Vitamin D3 is essential for immunity and bone health, particularly during pandemics. A three-month course improved my energy and mood after I discovered my low levels. This reliable product from Solgar enhances calcium absorption, vascular health, and reduces the risk of cancer. I wholeheartedly recommend it to everyone.
Read More
7.5
Cancer prevention
Taking vitamin D3 is vital to avoid upper respiratory infections and several diseases, including cancer. Regular use can significantly improve health outcomes. Smaller capsules make it easy to integrate into my routine.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
- All Researches
9
Vitamin D3 derivatives improve cancer treatment
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Highly relevant to cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
8
Vitamin D3 offers anti-cancer benefits
Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.
Study emphasizes isolated effects
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Read More
8
Vitamin D's potential in CRC
Exploration and Identification of Vitamin D and Related Genes as Potential Biomarkers for Colorectal Tumors.
High relevance to cancer treatment
We delved into the intriguing relationship between vitamin D and colorectal cancer (CRC) to uncover how this nutrient might influence cancer development and treatment. The study involved measuring the serum levels of active vitamin D (1,25(OH)D) in different groups, including those with normal conditions, colorectal adenomas (CRA), and colorectal cancer (CRC).
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Read More
8
Vitamin D3 enhances glioma treatment
Enhanced Antiglioma Effect by a Vitamin D3-Inserted Lipid Hybrid Neutrophil Membrane Biomimetic Multimodal Nanoplatform.
Significant relevance to cancer treatment
We developed an innovative treatment approach using a special type of nanoplatform that combines vitamin D3 with neutrophil membranes and chemotherapy medication doxorubicin. This platform was specifically designed to target glioblastoma, which is known as one of the most aggressive and challenging brain cancers.
Not only did we find that this treatment method was effective in delivering chemotherapy and promoting cell death in tumor cells, but we also observed that it significantly boosted the immune response against cancer. The combination activated a specific immune pathway, leading to increased production of important signaling molecules that can help fight tumors. This resulted in a shift from an immune-resistant environment to one more responsive to treatment, encouraging immune cells to attack the cancer more effectively.
Overall, the use of vitamin D3 in this multimodal strategy shows great promise for enhancing cancer therapy, opening the door for further exploration into its potential for improving glioma treatment outcomes and possibly developing more effective immune therapies.
Not only did we find that this treatment method was effective in delivering chemotherapy and promoting cell death in tumor cells, but we also observed that it significantly boosted the immune response against cancer. The combination activated a specific immune pathway, leading to increased production of important signaling molecules that can help fight tumors. This resulted in a shift from an immune-resistant environment to one more responsive to treatment, encouraging immune cells to attack the cancer more effectively.
Overall, the use of vitamin D3 in this multimodal strategy shows great promise for enhancing cancer therapy, opening the door for further exploration into its potential for improving glioma treatment outcomes and possibly developing more effective immune therapies.
Read More
8
Vitamin D3 improves nutritional status
The Effects of Omega-3 Fatty Acids and Vitamin D Supplementation on the Nutritional Status of Women with Breast Cancer in Palestine: An Open-Label Randomized Controlled Trial.
Supplementation combination affects outcomes
We assessed the effects of vitamin D3 supplementation in women newly diagnosed with breast cancer, focusing on how it can enhance nutritional health. In a randomized controlled trial, 88 women were split into four groups to receive either omega-3 fatty acids, vitamin D3, both, or none at all.
Over nine weeks, we noticed that those who took daily omega-3s and weekly vitamin D3 showed notable improvements in their nutritional status. We used various tools—including self-assessments and blood tests—to gauge changes. The results indicated better dietary intake, higher blood albumin levels, and improved subjective assessments of their overall nutrition in those who received supplementation.
Although vitamin D3 was part of the combination therapy with omega-3, it contributed positively to the participants' health during active cancer treatment. Thus, supplementing with vitamin D3 appears to be a beneficial strategy in managing the nutritional challenges faced by women undergoing treatment for breast cancer.
Over nine weeks, we noticed that those who took daily omega-3s and weekly vitamin D3 showed notable improvements in their nutritional status. We used various tools—including self-assessments and blood tests—to gauge changes. The results indicated better dietary intake, higher blood albumin levels, and improved subjective assessments of their overall nutrition in those who received supplementation.
Although vitamin D3 was part of the combination therapy with omega-3, it contributed positively to the participants' health during active cancer treatment. Thus, supplementing with vitamin D3 appears to be a beneficial strategy in managing the nutritional challenges faced by women undergoing treatment for breast cancer.
Read More
User Reviews
USERS' SCORE
Good
Based on 10 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Effective for bone density
This product is great! It's easy to swallow and has no aftertaste. Due to lower bone density from radiation treatment for cancer, I take these alongside calcium supplements, ensuring my Vitamin D intake stays healthy.
9.5
Stronger immunity
Vitamin D3 is essential for immunity and bone health, particularly during pandemics. A three-month course improved my energy and mood after I discovered my low levels. This reliable product from Solgar enhances calcium absorption, vascular health, and reduces the risk of cancer. I wholeheartedly recommend it to everyone.
Read More
7.5
Cancer prevention
Taking vitamin D3 is vital to avoid upper respiratory infections and several diseases, including cancer. Regular use can significantly improve health outcomes. Smaller capsules make it easy to integrate into my routine.
8.8
Improved immunity
I regularly take vitamin D3 from Solgar, particularly during the autumn-winter period. A blood test revealed my levels were significantly low. This vitamin promotes bone health, immunity, and overall well-being. After normalising my vitamin D levels, I noticed improvements in my sleep and the condition of my hair and nails. I recommend this vitamin to everyone as a preventative measure.
Read More
7.5
Promotes health
Like D3, it can prevent serious illnesses, including cancer. The ease of swallowing the small tablets makes them convenient. Combining with fatty foods aids absorption. I maintain a regular dosage for optimal health benefits.
