' 
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3
25 mcg (1,000 IU)
125%
Top Medical Research Studies
9
Vitamin D3's protective effects on neuropathy
The therapeutic potential of 1, 25-dihydroxy vitamin D3 on cisplatin-affected neurological functions is associated with the regulation of oxidative stress and inflammatory markers as well as levels of MMP2/9.
Addresses vitamin D3 effects on neuropathy
We examined the effects of calcitriol, the active form of vitamin D3, on neuropathy induced by the chemotherapy drug cisplatin. By administering cisplatin to male Wistar rats over a five-week period, we aimed to observe how vitamin D3 might protect against the nerve damage typically associated with cancer treatments.
Our findings revealed that cisplatin treatment led to cognitive impairments and reduced levels of brain-derived neurotrophic factor (BDNF), which is essential for nerve health. Additionally, we noted an increase in oxidative stress and inflammation, characterized by elevated levels of harmful molecules and decreased antioxidant defenses. However, when we introduced calcitriol supplementation, the detrimental effects seemed to lessen. It improved memory function and partially restored nerve function, evidenced by enhanced sensory nerve conduction.
Furthermore, we found that calcitriol helped to balance oxidative stress and inflammation, reducing markers associated with nerve damage. Overall, our study suggests that vitamin D3 could be a promising option for mitigating nerve damage caused by chemotherapy, highlighting its potential as a neuroprotective agent worth further exploration.
Our findings revealed that cisplatin treatment led to cognitive impairments and reduced levels of brain-derived neurotrophic factor (BDNF), which is essential for nerve health. Additionally, we noted an increase in oxidative stress and inflammation, characterized by elevated levels of harmful molecules and decreased antioxidant defenses. However, when we introduced calcitriol supplementation, the detrimental effects seemed to lessen. It improved memory function and partially restored nerve function, evidenced by enhanced sensory nerve conduction.
Furthermore, we found that calcitriol helped to balance oxidative stress and inflammation, reducing markers associated with nerve damage. Overall, our study suggests that vitamin D3 could be a promising option for mitigating nerve damage caused by chemotherapy, highlighting its potential as a neuroprotective agent worth further exploration.
Read More
8
Vitamin D3 improves neuropathy outcomes
High dose cholecalciferol supplementation causing morning blood pressure reduction in patients with type 1 diabetes mellitus and cardiovascular autonomic neuropathy.
Relevant findings on neuropathy effects
We evaluated how high-dose vitamin D3 supplementation affects cardiovascular autonomic neuropathy (CAN) in patients with type 1 diabetes. In this study, we observed two groups: one with CAN and another without. The group with CAN showed higher blood pressure and less nocturnal dipping compared to those without CAN.
After 12 weeks of receiving vitamin D3, those in the CAN group displayed improvements in their CAN parameters. Specifically, their total power and very low frequency metrics showed significant enhancements. Additionally, we found that the CAN group experienced a reduction in morning systolic blood pressure and morning blood pressure surge.
Overall, these findings suggest that vitamin D3 may offer benefits for individuals struggling with cardiovascular autonomic neuropathy, potentially leading to better blood pressure control. This study points to a promising avenue for managing neuropathy through vitamin D3 supplementation.
After 12 weeks of receiving vitamin D3, those in the CAN group displayed improvements in their CAN parameters. Specifically, their total power and very low frequency metrics showed significant enhancements. Additionally, we found that the CAN group experienced a reduction in morning systolic blood pressure and morning blood pressure surge.
Overall, these findings suggest that vitamin D3 may offer benefits for individuals struggling with cardiovascular autonomic neuropathy, potentially leading to better blood pressure control. This study points to a promising avenue for managing neuropathy through vitamin D3 supplementation.
Read More
Most Useful Reviews
8.8
Easy to take
My husband has diabetic neuropathy in his feet, and these are easy for him to swallow, particularly as he has difficulty swallowing (dysphagia). They are part of his regimen, along with other supplements.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
- All Researches
9
Vitamin D3's protective effects on neuropathy
The therapeutic potential of 1, 25-dihydroxy vitamin D3 on cisplatin-affected neurological functions is associated with the regulation of oxidative stress and inflammatory markers as well as levels of MMP2/9.
Addresses vitamin D3 effects on neuropathy
We examined the effects of calcitriol, the active form of vitamin D3, on neuropathy induced by the chemotherapy drug cisplatin. By administering cisplatin to male Wistar rats over a five-week period, we aimed to observe how vitamin D3 might protect against the nerve damage typically associated with cancer treatments.
Our findings revealed that cisplatin treatment led to cognitive impairments and reduced levels of brain-derived neurotrophic factor (BDNF), which is essential for nerve health. Additionally, we noted an increase in oxidative stress and inflammation, characterized by elevated levels of harmful molecules and decreased antioxidant defenses. However, when we introduced calcitriol supplementation, the detrimental effects seemed to lessen. It improved memory function and partially restored nerve function, evidenced by enhanced sensory nerve conduction.
Furthermore, we found that calcitriol helped to balance oxidative stress and inflammation, reducing markers associated with nerve damage. Overall, our study suggests that vitamin D3 could be a promising option for mitigating nerve damage caused by chemotherapy, highlighting its potential as a neuroprotective agent worth further exploration.
Our findings revealed that cisplatin treatment led to cognitive impairments and reduced levels of brain-derived neurotrophic factor (BDNF), which is essential for nerve health. Additionally, we noted an increase in oxidative stress and inflammation, characterized by elevated levels of harmful molecules and decreased antioxidant defenses. However, when we introduced calcitriol supplementation, the detrimental effects seemed to lessen. It improved memory function and partially restored nerve function, evidenced by enhanced sensory nerve conduction.
Furthermore, we found that calcitriol helped to balance oxidative stress and inflammation, reducing markers associated with nerve damage. Overall, our study suggests that vitamin D3 could be a promising option for mitigating nerve damage caused by chemotherapy, highlighting its potential as a neuroprotective agent worth further exploration.
Read More
8
Vitamin D3 improves neuropathy outcomes
High dose cholecalciferol supplementation causing morning blood pressure reduction in patients with type 1 diabetes mellitus and cardiovascular autonomic neuropathy.
Relevant findings on neuropathy effects
We evaluated how high-dose vitamin D3 supplementation affects cardiovascular autonomic neuropathy (CAN) in patients with type 1 diabetes. In this study, we observed two groups: one with CAN and another without. The group with CAN showed higher blood pressure and less nocturnal dipping compared to those without CAN.
After 12 weeks of receiving vitamin D3, those in the CAN group displayed improvements in their CAN parameters. Specifically, their total power and very low frequency metrics showed significant enhancements. Additionally, we found that the CAN group experienced a reduction in morning systolic blood pressure and morning blood pressure surge.
Overall, these findings suggest that vitamin D3 may offer benefits for individuals struggling with cardiovascular autonomic neuropathy, potentially leading to better blood pressure control. This study points to a promising avenue for managing neuropathy through vitamin D3 supplementation.
After 12 weeks of receiving vitamin D3, those in the CAN group displayed improvements in their CAN parameters. Specifically, their total power and very low frequency metrics showed significant enhancements. Additionally, we found that the CAN group experienced a reduction in morning systolic blood pressure and morning blood pressure surge.
Overall, these findings suggest that vitamin D3 may offer benefits for individuals struggling with cardiovascular autonomic neuropathy, potentially leading to better blood pressure control. This study points to a promising avenue for managing neuropathy through vitamin D3 supplementation.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Easy to take
My husband has diabetic neuropathy in his feet, and these are easy for him to swallow, particularly as he has difficulty swallowing (dysphagia). They are part of his regimen, along with other supplements.
