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SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Vitamin D3 (as cholecalciferol)
125 mcg (5000 IU)
625%
Top Medical Research Studies
8
Vitamin D3 offers anti-cancer benefits
Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.
Study emphasizes isolated effects
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Read More
9
Vitamin D3 derivatives improve cancer treatment
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Highly relevant to cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
8
Vitamin D's potential in CRC
Exploration and Identification of Vitamin D and Related Genes as Potential Biomarkers for Colorectal Tumors.
High relevance to cancer treatment
We delved into the intriguing relationship between vitamin D and colorectal cancer (CRC) to uncover how this nutrient might influence cancer development and treatment. The study involved measuring the serum levels of active vitamin D (1,25(OH)D) in different groups, including those with normal conditions, colorectal adenomas (CRA), and colorectal cancer (CRC).
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Read More
Most Useful Reviews
8.8
Positive lab results
I've been taking these capsules for several months, and recent lab results showed my Vitamin D levels increased from 19 to 35.5. I take one capsule with my morning medications and am pleased with the outcome. As a cancer patient, I've been advised that maintaining good Vitamin D levels is essential, so I'll continue using this brand.
Read More
9.5
Daily D3 intake
I have used Solgar vitamin D3 for several years, mainly because I avoid sun exposure due to skin cancer. I take it every day, and it's a very good product!
Read More
8.8
Vitamin D3 benefits
Good Vitamin D3 normalises phosphorus-calcium metabolism and strengthens bone tissue, the immune system, and the nervous system. It is essential for children, women, and men, particularly during a pandemic. I believe it's crucial to get tested.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.5
9
Vitamin D3 derivatives improve cancer treatment
Synthetic Studies on Vitamin D Derivatives with Diverse but Selective Biological Activities.
Highly relevant to cancer treatment
We focused on how modified forms of vitamin D3 can positively affect cancer treatment. The study revealed that a specific derivative, known as MART-10, demonstrated significant anti-tumor effects in mouse models. When administered at low doses, this compound showed robust anti-cancer activity against BxpC-3 cancer cells.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Additionally, we explored a new vitamin D analog, AH-1, which was found to enhance bone formation without the usual side effects associated with vitamin D treatments. This is particularly promising for osteoporosis patients. Another derivative named NS-74c even exhibited potent antagonist activity against the vitamin D receptor, indicating a potential for varied therapeutic uses.
Overall, our research highlighted the potential of vitamin D3 derivatives to tackle cancer while minimizing adverse effects. This approach opens new doors for therapeutic options in oncology, providing a glimpse into how modified vitamin D can improve treatment outcomes for patients.
Read More
8
Vitamin D3 offers anti-cancer benefits
Liposomal encapsulation of cholecalciferol mitigates toxicity and delays tumor growth.
Study emphasizes isolated effects
We investigated the potential of vitamin D3, also known as cholecalciferol, in combating cancer while addressing concerns about its toxicity at higher doses. This study focused on enhancing the effectiveness of vitamin D3 through a clever method called liposomal encapsulation, which helps minimize side effects.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
We prepared liposomal vitamin D3 (VD-LP) and conducted various tests to understand its capabilities. We found that this encapsulated form not only maintained high efficiency but also demonstrated improved stability. Our analyses showed that VD-LP had strong effects against cancer cells from colorectal, breast, and prostate cancers. Remarkably, it affected gene expression in immune cells, boosting elements that help fight infections and support the body's defenses.
Notably, VD-LP did a great job slowing tumor growth in mice and improved their survival rates without causing adverse effects like hypercalcemia, which is often a concern with regular vitamin D3 use. This evidence indicates that liposomal encapsulation of vitamin D3 could offer an effective cancer treatment strategy while minimizing unwanted side effects.
We believe this may pave the way for further research and clinical applications, showcasing vitamin D3 as a valuable addition to cancer therapy.
Read More
8
Vitamin D's potential in CRC
Exploration and Identification of Vitamin D and Related Genes as Potential Biomarkers for Colorectal Tumors.
High relevance to cancer treatment
We delved into the intriguing relationship between vitamin D and colorectal cancer (CRC) to uncover how this nutrient might influence cancer development and treatment. The study involved measuring the serum levels of active vitamin D (1,25(OH)D) in different groups, including those with normal conditions, colorectal adenomas (CRA), and colorectal cancer (CRC).
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Our findings highlighted a significant drop in vitamin D levels in CRC patients, with levels falling to 19.00 µg/mL compared to 42.99 µg/mL in normal individuals. Additionally, we conducted bioinformatics analysis to pinpoint genes linked to vitamin D and colorectal cancer, testing these using HCT116 and HT29 cell lines.
We observed that vitamin D can inhibit the growth and spread of colon cancer cells, leading to a reduction in the activity of certain cancer-promoting genes. Interestingly, our analysis also showed that a diagnostic model based on five key vitamin D-related genes exhibited high diagnostic efficiency. This reveals vitamin D's potential as a supportive approach for CRC diagnosis and treatment, offering hope for improved cancer management.
Read More
8
Vitamin D3 enhances glioma treatment
Enhanced Antiglioma Effect by a Vitamin D3-Inserted Lipid Hybrid Neutrophil Membrane Biomimetic Multimodal Nanoplatform.
Significant relevance to cancer treatment
We developed an innovative treatment approach using a special type of nanoplatform that combines vitamin D3 with neutrophil membranes and chemotherapy medication doxorubicin. This platform was specifically designed to target glioblastoma, which is known as one of the most aggressive and challenging brain cancers.
Not only did we find that this treatment method was effective in delivering chemotherapy and promoting cell death in tumor cells, but we also observed that it significantly boosted the immune response against cancer. The combination activated a specific immune pathway, leading to increased production of important signaling molecules that can help fight tumors. This resulted in a shift from an immune-resistant environment to one more responsive to treatment, encouraging immune cells to attack the cancer more effectively.
Overall, the use of vitamin D3 in this multimodal strategy shows great promise for enhancing cancer therapy, opening the door for further exploration into its potential for improving glioma treatment outcomes and possibly developing more effective immune therapies.
Not only did we find that this treatment method was effective in delivering chemotherapy and promoting cell death in tumor cells, but we also observed that it significantly boosted the immune response against cancer. The combination activated a specific immune pathway, leading to increased production of important signaling molecules that can help fight tumors. This resulted in a shift from an immune-resistant environment to one more responsive to treatment, encouraging immune cells to attack the cancer more effectively.
Overall, the use of vitamin D3 in this multimodal strategy shows great promise for enhancing cancer therapy, opening the door for further exploration into its potential for improving glioma treatment outcomes and possibly developing more effective immune therapies.
Read More
8
Vitamin D3 improves nutritional status
The Effects of Omega-3 Fatty Acids and Vitamin D Supplementation on the Nutritional Status of Women with Breast Cancer in Palestine: An Open-Label Randomized Controlled Trial.
Supplementation combination affects outcomes
We assessed the effects of vitamin D3 supplementation in women newly diagnosed with breast cancer, focusing on how it can enhance nutritional health. In a randomized controlled trial, 88 women were split into four groups to receive either omega-3 fatty acids, vitamin D3, both, or none at all.
Over nine weeks, we noticed that those who took daily omega-3s and weekly vitamin D3 showed notable improvements in their nutritional status. We used various tools—including self-assessments and blood tests—to gauge changes. The results indicated better dietary intake, higher blood albumin levels, and improved subjective assessments of their overall nutrition in those who received supplementation.
Although vitamin D3 was part of the combination therapy with omega-3, it contributed positively to the participants' health during active cancer treatment. Thus, supplementing with vitamin D3 appears to be a beneficial strategy in managing the nutritional challenges faced by women undergoing treatment for breast cancer.
Over nine weeks, we noticed that those who took daily omega-3s and weekly vitamin D3 showed notable improvements in their nutritional status. We used various tools—including self-assessments and blood tests—to gauge changes. The results indicated better dietary intake, higher blood albumin levels, and improved subjective assessments of their overall nutrition in those who received supplementation.
Although vitamin D3 was part of the combination therapy with omega-3, it contributed positively to the participants' health during active cancer treatment. Thus, supplementing with vitamin D3 appears to be a beneficial strategy in managing the nutritional challenges faced by women undergoing treatment for breast cancer.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
9.5
Daily D3 intake
I have used Solgar vitamin D3 for several years, mainly because I avoid sun exposure due to skin cancer. I take it every day, and it's a very good product!
8.8
Vitamin D3 benefits
Good Vitamin D3 normalises phosphorus-calcium metabolism and strengthens bone tissue, the immune system, and the nervous system. It is essential for children, women, and men, particularly during a pandemic. I believe it's crucial to get tested.
8.8
Immunity boost
Replenishing vitamin D deficiency boosts muscle tone and immunity, necessary for thyroid function and blood clotting. It helps restore nerve sheaths and regulates blood pressure while preventing the growth of cancer cells.
8.8
Positive lab results
I've been taking these capsules for several months, and recent lab results showed my Vitamin D levels increased from 19 to 35.5. I take one capsule with my morning medications and am pleased with the outcome. As a cancer patient, I've been advised that maintaining good Vitamin D levels is essential, so I'll continue using this brand.
Read More
7.5
Nerve protection
Vitamin D enhances muscle tone, immunity, and thyroid function. My two-month intake increased my blood vitamin D level and helps in regulating blood pressure, inhibiting cancer cell growth, and restoring nerve protection.
