Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.2
USERS' SCORE
Good
Based on 2 Reviews
8.2
Supplement Facts
Serving Size: 1 Vegetable Capsule
Amount Per Serving
%DV
Vitamin B6 (as pyridoxine HCl)
100 mg
5,882%
Top Medical Research Studies
9.5
We looked into how pyridoxine, or vitamin B6, could impact anxiety, particularly in those with a deficiency. A case study featuring a 57-year-old man with chronic alcoholism showed that he had developed anxiety and other neurological symptoms despite being on anti-epileptic medications. After discovering he had a pyridoxine deficiency, his symptoms, including anxiety, completely disappeared with vitamin B6 treatment. This highlights the potential importance of checking for pyridoxine levels in patients presenting with neurological issues, especially when anxiety is involved.
Read More
9
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Read More
7
We engaged in a double-blind study involving 478 young adults to explore the effects of high-dose Vitamin B6 and B12 supplementation on anxiety levels. Over a month of treatment, we compared these vitamin supplements against a placebo, focusing on their potential to balance neural inhibition and excitation—two processes crucial for emotional regulation.
Our findings revealed that participants who took Vitamin B6 reported lower levels of anxiety compared to those on the placebo. Interestingly, there was a trend suggesting a mild reduction in depression as well. Additionally, we noticed that Vitamin B6 enhanced a specific measure known as surround suppression of visual contrast detection, hinting at its role in increasing neural inhibition.
Conversely, while Vitamin B12 also showed some trends towards influencing anxiety and visual processing, the results were not as pronounced or reliable as those observed with Vitamin B6. Overall, our results underline the potential of high-dose Vitamin B6 supplementation in reducing anxiety and strengthening the brain's inhibitory functions, tying back to its known involvement in GABA synthesis.
Our findings revealed that participants who took Vitamin B6 reported lower levels of anxiety compared to those on the placebo. Interestingly, there was a trend suggesting a mild reduction in depression as well. Additionally, we noticed that Vitamin B6 enhanced a specific measure known as surround suppression of visual contrast detection, hinting at its role in increasing neural inhibition.
Conversely, while Vitamin B12 also showed some trends towards influencing anxiety and visual processing, the results were not as pronounced or reliable as those observed with Vitamin B6. Overall, our results underline the potential of high-dose Vitamin B6 supplementation in reducing anxiety and strengthening the brain's inhibitory functions, tying back to its known involvement in GABA synthesis.
Read More
Most Useful Reviews
7.5
Reduced panic attacks
1 people found this helpful
Good, I read extensively about this before, but unexpectedly realised that panic attacks affected me too. To be honest, I hadn’t taken B vitamins before, except during pregnancy. I bought some and started taking them immediately. As a result, thanks to the medication, I felt lighter and free of anxiety. I can’t say that the panic attacks have vanished completely, but it has improved significantly and the spasms have become less frequent. I’m still taking it, but we shall see.
Read More
6
Effective during stress
It seemed to help me during stressful periods, especially when my anxiety was at its worst.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.2
- All Researches
9.5
We looked into how pyridoxine, or vitamin B6, could impact anxiety, particularly in those with a deficiency. A case study featuring a 57-year-old man with chronic alcoholism showed that he had developed anxiety and other neurological symptoms despite being on anti-epileptic medications. After discovering he had a pyridoxine deficiency, his symptoms, including anxiety, completely disappeared with vitamin B6 treatment. This highlights the potential importance of checking for pyridoxine levels in patients presenting with neurological issues, especially when anxiety is involved.
Read More
9
Our investigation aimed to understand how vitamin B6 might influence anxiety, particularly among individuals facing mental health challenges like depression and stress. We assessed the mental health of 82 gastric cancer patients compared to 95 healthy individuals, using a questionnaire that evaluated their levels of anxiety and depression.
Interestingly, our findings showed a noteworthy link between vitamin B6 intake and decreased anxiety levels among those with depression. Specifically, vitamin B6 emerged as a significant protective factor, suggesting that higher intake could help reduce anxiety symptoms. This trend underscores the potential importance of certain dietary choices in managing mental health.
Our study also highlighted that other dietary factors could affect mental health. For instance, sugar and salt were found to increase anxiety risks, while foods rich in vitamins, minerals, and phytochemicals were associated with lower incidences of stress and depression. This points to the broader picture that healthy eating patterns may assist in fostering mental well-being and, in turn, impact conditions like gastric cancer.
However, while these initial findings are promising, we acknowledge the need for further research to fully understand these relationships and the underlying mechanisms involved. The interplay between diet, mental health, and physical health, such as cancer risks, is complex and warrants deeper exploration.
Interestingly, our findings showed a noteworthy link between vitamin B6 intake and decreased anxiety levels among those with depression. Specifically, vitamin B6 emerged as a significant protective factor, suggesting that higher intake could help reduce anxiety symptoms. This trend underscores the potential importance of certain dietary choices in managing mental health.
Our study also highlighted that other dietary factors could affect mental health. For instance, sugar and salt were found to increase anxiety risks, while foods rich in vitamins, minerals, and phytochemicals were associated with lower incidences of stress and depression. This points to the broader picture that healthy eating patterns may assist in fostering mental well-being and, in turn, impact conditions like gastric cancer.
However, while these initial findings are promising, we acknowledge the need for further research to fully understand these relationships and the underlying mechanisms involved. The interplay between diet, mental health, and physical health, such as cancer risks, is complex and warrants deeper exploration.
Read More
9
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Read More
8
We conducted a clinical trial that looked into whether vitamin B6 could help prevent postpartum depression (PPD) among mothers at risk. This single-blind, placebo-controlled study involved 81 pregnant women in Isfahan, Iran, who were divided into two groups—one group received 80 mg of vitamin B6, while the other received a placebo.
Participants were assessed for their risk of developing PPD using a series of structured questionnaires. After the intervention, we measured the depression levels again, and while vitamin B6 showed promise in reducing PPD scores in these women, it was not specifically tested for anxiety.
The results indicated that mothers taking vitamin B6 had significantly lower depression scores after the intervention compared to those taking the placebo. However, it's important to note that this study did not directly measure the impact of vitamin B6 on anxiety levels, which somewhat limits its application for anxiety disorders. Overall, these findings suggest that while vitamin B6 can help in reducing symptoms of PPD, its benefits for anxiety specifically remain unclear.
Participants were assessed for their risk of developing PPD using a series of structured questionnaires. After the intervention, we measured the depression levels again, and while vitamin B6 showed promise in reducing PPD scores in these women, it was not specifically tested for anxiety.
The results indicated that mothers taking vitamin B6 had significantly lower depression scores after the intervention compared to those taking the placebo. However, it's important to note that this study did not directly measure the impact of vitamin B6 on anxiety levels, which somewhat limits its application for anxiety disorders. Overall, these findings suggest that while vitamin B6 can help in reducing symptoms of PPD, its benefits for anxiety specifically remain unclear.
Read More
8
Magnesium and B6 improve anxiety
We explored how magnesium and vitamin B6 affect anxiety in adults dealing with significant stress. In a study that lasted eight weeks, participants who were experiencing high levels of stress were given either a combination of magnesium and vitamin B6 or magnesium alone.
Both groups showed reductions in their anxiety scores, particularly in the first four weeks. However, the combination of magnesium with vitamin B6 appeared to provide better results for participants' perceived ability to engage in physical activities by the end of the fourth week.
Although both treatments were helpful in easing anxiety levels, it's important to note that we cannot definitively isolate the effects of vitamin B6 from magnesium, as the study examined them together. Overall, this suggests that magnesium supplementation, with or without vitamin B6, may offer a meaningful improvement in mental wellness for those dealing with stress.
Both groups showed reductions in their anxiety scores, particularly in the first four weeks. However, the combination of magnesium with vitamin B6 appeared to provide better results for participants' perceived ability to engage in physical activities by the end of the fourth week.
Although both treatments were helpful in easing anxiety levels, it's important to note that we cannot definitively isolate the effects of vitamin B6 from magnesium, as the study examined them together. Overall, this suggests that magnesium supplementation, with or without vitamin B6, may offer a meaningful improvement in mental wellness for those dealing with stress.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Reduced panic attacks
1 people found this helpful
Good, I read extensively about this before, but unexpectedly realised that panic attacks affected me too. To be honest, I hadn’t taken B vitamins before, except during pregnancy. I bought some and started taking them immediately. As a result, thanks to the medication, I felt lighter and free of anxiety. I can’t say that the panic attacks have vanished completely, but it has improved significantly and the spasms have become less frequent. I’m still taking it, but we shall see.
Read More
6
Effective during stress
It seemed to help me during stressful periods, especially when my anxiety was at its worst.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Sousou JM, Griffith EM, Marsalisi C, Reddy P. Pyridoxine Deficiency and Neurologic Dysfunction: An Unlikely Association. Cureus. 2023;15:e47647. doi:10.7759/cureus.47647
- Dreischmeier E, Zuloaga A, Kotloski RJ, Karasov AO, Gidal BE. Levetiracetam-associated irritability and potential role of vitamin B6 use in veterans with epilepsy. Epilepsy Behav Rep. 2021;16:100452. doi:10.1016/j.ebr.2021.100452
- Mozaffari H, Darooghegi Mofrad M, Surkan PJ, Askari M, Azadbakht L. Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study. Public Health Nutr. 2021;24:1787. doi:10.1017/S1368980020002943
- Pouteau E, Kabir-Ahmadi M, Noah L, Mazur A, Dye L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13:e0208454. doi:10.1371/journal.pone.0208454
- De Souza MC, Walker AF, Robinson PA, Bolland K. A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. J Womens Health Gend Based Med. 2000;9:131.
- Bermond P. Therapy of side effects of oral contraceptive agents with vitamin B6. Acta Vitaminol Enzymol. 1982;4:45.
- Vahid F, Rahmani W, Davoodi SH, Bohn T. Mental Health Conditions, Including Depression and Stress, Are Associated with Increased Odds of Gastric Cancer-Insights into the Role of Diet: A Case-Control Study. Nutrients. 2023;15. doi:10.3390/nu15234981
- Ding X, Wen Y, Ma X, Zhang Y, Cheng Y, et al. Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring. Environ Sci Ecotechnol. 2023;13:100224. doi:10.1016/j.ese.2022.100224
- Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37:e2852. doi:10.1002/hup.2852
- Noah L, Morel V, Bertin C, Pouteau E, Macian N, et al. Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled Study. Nutrients. 2022;14. doi:10.3390/nu14091863
- Rizzo R, Prato A, Scerbo M, Saia F, Barone R, et al. Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study. Nutrients. 2022;14. doi:10.3390/nu14040852
- Khodadad M, Bahadoran P, Kheirabadi GR, Sabzghabaee AM. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial. Int J Prev Med. 2021;12:136. doi:10.4103/ijpvm.IJPVM_240_19
- Noah L, Dye L, Bois De Fer B, Mazur A, Pickering G, et al. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial. Stress Health. 2021;37:1000. doi:10.1002/smi.3051
- Walia V, Garg C, Garg M. Lithium potentiated, pyridoxine abolished and fluoxetine attenuated the anxiolytic effect of diazepam in mice. Brain Res Bull. 2019;150:343. doi:10.1016/j.brainresbull.2019.06.008
- Kafeshani M, Feizi A, Esmaillzadeh A, Keshteli AH, Afshar H, et al. Higher vitamin B intake is associated with lower depression and anxiety risk in women but not in men: A large cross-sectional study. Int J Vitam Nutr Res. 2020;90:484. doi:10.1024/0300-9831/a000589
