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SCIENTIFIC SCORE
Moderately Effective
Based on 1 Researches
8
USERS' SCORE
Good
Based on 7 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (as zinc picolinate)
22 mg
200%
Top Medical Research Studies
8
Zinc may mitigate granisetron constipation
Carbon monoxide contributes to the constipating effects of granisetron in rat colon.
Specific interaction with granisetron
We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Read More
Most Useful Reviews
8.8
Effective for digestion
Inexpensive, transparent ingredients, and good quality! This nutritional supplement effectively improves digestion and helps with constipation. Its lack of taste makes it easy to swallow, and the packaging blocks sunlight. It's affordable and offers a high CP level, making it a worthwhile purchase.
Read More
9.5
Alleviated discomfort
I'm pleased to report that this supplement has significantly alleviated my occasional constipation. While taste isn't a primary concern, I appreciate that these tasteless capsules are easy to swallow without an aftertaste. With its high-quality ingredients and effective formula, it's become essential for my digestive health.
Read More
8.8
Very affordable
Very good! This inexpensive nutritional supplement improves digestion and helps with constipation with ease. It has transparent ingredients and comes in large portions, making it easy to absorb. The simple packaging effectively blocks sunlight and ensures quality.
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Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Researches
8
8
Zinc may mitigate granisetron constipation
Carbon monoxide contributes to the constipating effects of granisetron in rat colon.
Specific interaction with granisetron
We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.7
9.5
Alleviated discomfort
I'm pleased to report that this supplement has significantly alleviated my occasional constipation. While taste isn't a primary concern, I appreciate that these tasteless capsules are easy to swallow without an aftertaste. With its high-quality ingredients and effective formula, it's become essential for my digestive health.
Read More
9.5
Effective for autism
The anti-oxidative activity is very effective! It's helpful for issues like autism and constipation, making it a beneficial supplement overall.
8.8
Improved bowel function
I don't know if it's a placebo effect, but my bowel function has become more active, and my constipation has improved significantly. My stomach feels refreshed, and I no longer feel sleepy during the day, possibly because I sleep deeper. Additionally, I believe my skin has improved. These are the effects I have experienced after using it for about a month and a half.
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8.8
Effective for digestion
Inexpensive, transparent ingredients, and good quality! This nutritional supplement effectively improves digestion and helps with constipation. Its lack of taste makes it easy to swallow, and the packaging blocks sunlight. It's affordable and offers a high CP level, making it a worthwhile purchase.
Read More
8.8
Highly recommend product
I’m from India and have IBS with constipation, leading to a lean body due to my restricted diet. I can easily break the tablet into smaller doses, as I can't tolerate large amounts. Zinc has tightened my skin and improved muscle tone. A great product for those battling immunity and constipation.
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