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SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
USERS' SCORE
Good
Based on 7 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (as zinc picolinate)
22 mg
200%
Top Medical Research Studies
8
Zinc conditioner benefits scalp psoriasis
Efficacy and safety of supramolecular active zinc in the treatment of scalp psoriasis: a multicentre, randomized, observed-blind, parallel-group, placebo- and active-controlled noninferiority trial.
Directly addresses zinc's effectiveness
We delved into the effectiveness of a zinc-based hair conditioner specifically designed for treating scalp psoriasis. This study was a well-structured clinical trial involving 211 participants, where individuals were divided into three groups: those receiving the specialized zinc treatment, a placebo, and a control group given calcipotriol ointment. Remarkably, the trial was multicenter and observed-blind, which adds credibility to the findings.
Our results revealed that the zinc conditioner led to a 39% disease control rate after four weeks, compared to 25% for the placebo and 37% for the calcipotriol ointment group. This means that the zinc treatment significantly outperformed the placebo while being on par with the active control variant. In essence, those using the zinc product experienced better management of their scalp psoriasis than those using a non-active alternative.
Overall, our findings highlight that a supramolecular active zinc antidandruff formulation is not just effective for treating scalp psoriasis but also helps in maintaining results over time and potentially preventing future flare-ups. This offers a promising new avenue for patients seeking relief from this chronic condition.
Our results revealed that the zinc conditioner led to a 39% disease control rate after four weeks, compared to 25% for the placebo and 37% for the calcipotriol ointment group. This means that the zinc treatment significantly outperformed the placebo while being on par with the active control variant. In essence, those using the zinc product experienced better management of their scalp psoriasis than those using a non-active alternative.
Overall, our findings highlight that a supramolecular active zinc antidandruff formulation is not just effective for treating scalp psoriasis but also helps in maintaining results over time and potentially preventing future flare-ups. This offers a promising new avenue for patients seeking relief from this chronic condition.
Read More
9
Zinc improves acrodermatitis symptoms
Zinc Supplementation for Acrodermatitis Enteropathica Overlapped with Psoriasiform Lesions.
High relevance to zinc treatment
We evaluated the role of zinc treatment in addressing skin lesions that resemble psoriasis. Our focus was on a teenage boy who displayed characteristic symptoms of acrodermatitis enteropathica (AE) along with low serum zinc levels. Over time, his condition progressed into more widespread pustular psoriasis-like symptoms.
Notably, after initiating zinc supplementation, we observed a rapid improvement in his skin conditions. This led us to ponder whether zinc malabsorption might be a common factor triggering both AE and psoriasis-like skin issues. By restoring zinc levels, we believe we may have found a straightforward yet effective approach to manage these overlapping skin manifestations.
Overall, our findings suggest that maintaining a balanced zinc homeostasis could help alleviate symptoms for those affected by both AE and psoriasiform lesions.
Notably, after initiating zinc supplementation, we observed a rapid improvement in his skin conditions. This led us to ponder whether zinc malabsorption might be a common factor triggering both AE and psoriasis-like skin issues. By restoring zinc levels, we believe we may have found a straightforward yet effective approach to manage these overlapping skin manifestations.
Overall, our findings suggest that maintaining a balanced zinc homeostasis could help alleviate symptoms for those affected by both AE and psoriasiform lesions.
Read More
9
Zinc phthalocyanine shows promise
In Vitro and In Vivo Antipsoriatic Efficacy of Protected and Unprotected Sugar-Zinc Phthalocyanine Conjugates.
Focused on zinc-phthalocyanine effects
We aimed to explore the effectiveness of zinc phthalocyanine, especially its sugar-conjugated forms, in treating psoriasis. This skin condition affects millions and is characterized by rapid skin cell growth and inflammation. Through our research, we synthesized both protected and unprotected versions of these conjugates to see how well they worked against psoriasis-related symptoms.
In tests with cells designed to mimic psoriasis, we found that the protected glucose-zinc phthalocyanine (Glu-4-ZnPc-P) showed the strongest phototoxic effects. It was significantly more effective than other variations, demonstrating its potential as a targeted therapy. When we stimulated cells with IL-17A, a key player in psoriasis, we observed that this enhanced the uptake of the unprotected variant, suggesting an interesting interaction that could enhance treatment efficacy.
Additionally, our tests in a psoriasis-like model demonstrated that using Glu-4-ZnPc-P led to marked improvements in skin condition and reduced inflammation, indicating its promising role in photodynamic therapy. Overall, our findings underscore the potential of sugar-conjugated zinc phthalocyanine as a novel treatment avenue for psoriasis, paving the way for future clinical studies.
In tests with cells designed to mimic psoriasis, we found that the protected glucose-zinc phthalocyanine (Glu-4-ZnPc-P) showed the strongest phototoxic effects. It was significantly more effective than other variations, demonstrating its potential as a targeted therapy. When we stimulated cells with IL-17A, a key player in psoriasis, we observed that this enhanced the uptake of the unprotected variant, suggesting an interesting interaction that could enhance treatment efficacy.
Additionally, our tests in a psoriasis-like model demonstrated that using Glu-4-ZnPc-P led to marked improvements in skin condition and reduced inflammation, indicating its promising role in photodynamic therapy. Overall, our findings underscore the potential of sugar-conjugated zinc phthalocyanine as a novel treatment avenue for psoriasis, paving the way for future clinical studies.
Read More
Most Useful Reviews
9.5
Restored sense smell
Magic zinc! Zinc is essential for strengthening the immune system, cell renewal, protein synthesis, collagen formation, and addressing skin issues like psoriasis and acne. After taking zinc picolinate for a month and a half, I noticed remarkable changes: my hair stopped shedding, skin cleared up entirely, and my sense of smell returned after losing it due to Covid. I highly recommend this supplement!
Read More
9.5
Essential assistant
Zinc is my number one assistant for managing psoriasis and stomach gas. The three-month supply is cost-effective, and I highly recommend it due to the high quality provided by Solgar.
Read More
2.5
No progress noticed
After two weeks of taking these tablets, I have seen no change in my psoriasis plaques, which may have even worsened. I will seek alternative treatments.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
9
Zinc improves acrodermatitis symptoms
Zinc Supplementation for Acrodermatitis Enteropathica Overlapped with Psoriasiform Lesions.
High relevance to zinc treatment
We evaluated the role of zinc treatment in addressing skin lesions that resemble psoriasis. Our focus was on a teenage boy who displayed characteristic symptoms of acrodermatitis enteropathica (AE) along with low serum zinc levels. Over time, his condition progressed into more widespread pustular psoriasis-like symptoms.
Notably, after initiating zinc supplementation, we observed a rapid improvement in his skin conditions. This led us to ponder whether zinc malabsorption might be a common factor triggering both AE and psoriasis-like skin issues. By restoring zinc levels, we believe we may have found a straightforward yet effective approach to manage these overlapping skin manifestations.
Overall, our findings suggest that maintaining a balanced zinc homeostasis could help alleviate symptoms for those affected by both AE and psoriasiform lesions.
Notably, after initiating zinc supplementation, we observed a rapid improvement in his skin conditions. This led us to ponder whether zinc malabsorption might be a common factor triggering both AE and psoriasis-like skin issues. By restoring zinc levels, we believe we may have found a straightforward yet effective approach to manage these overlapping skin manifestations.
Overall, our findings suggest that maintaining a balanced zinc homeostasis could help alleviate symptoms for those affected by both AE and psoriasiform lesions.
Read More
9
Zinc phthalocyanine shows promise
In Vitro and In Vivo Antipsoriatic Efficacy of Protected and Unprotected Sugar-Zinc Phthalocyanine Conjugates.
Focused on zinc-phthalocyanine effects
We aimed to explore the effectiveness of zinc phthalocyanine, especially its sugar-conjugated forms, in treating psoriasis. This skin condition affects millions and is characterized by rapid skin cell growth and inflammation. Through our research, we synthesized both protected and unprotected versions of these conjugates to see how well they worked against psoriasis-related symptoms.
In tests with cells designed to mimic psoriasis, we found that the protected glucose-zinc phthalocyanine (Glu-4-ZnPc-P) showed the strongest phototoxic effects. It was significantly more effective than other variations, demonstrating its potential as a targeted therapy. When we stimulated cells with IL-17A, a key player in psoriasis, we observed that this enhanced the uptake of the unprotected variant, suggesting an interesting interaction that could enhance treatment efficacy.
Additionally, our tests in a psoriasis-like model demonstrated that using Glu-4-ZnPc-P led to marked improvements in skin condition and reduced inflammation, indicating its promising role in photodynamic therapy. Overall, our findings underscore the potential of sugar-conjugated zinc phthalocyanine as a novel treatment avenue for psoriasis, paving the way for future clinical studies.
In tests with cells designed to mimic psoriasis, we found that the protected glucose-zinc phthalocyanine (Glu-4-ZnPc-P) showed the strongest phototoxic effects. It was significantly more effective than other variations, demonstrating its potential as a targeted therapy. When we stimulated cells with IL-17A, a key player in psoriasis, we observed that this enhanced the uptake of the unprotected variant, suggesting an interesting interaction that could enhance treatment efficacy.
Additionally, our tests in a psoriasis-like model demonstrated that using Glu-4-ZnPc-P led to marked improvements in skin condition and reduced inflammation, indicating its promising role in photodynamic therapy. Overall, our findings underscore the potential of sugar-conjugated zinc phthalocyanine as a novel treatment avenue for psoriasis, paving the way for future clinical studies.
Read More
8
Zinc's role in psoriasis treatment
SLC35E1 promotes keratinocyte proliferation in psoriasis by regulating zinc homeostasis.
Relevant, yet context-dependent findings
We explored the link between zinc levels and psoriasis to understand how it might influence keratinocyte proliferation, a primary driver of this skin condition. In our investigation, we noticed that SLC35E1, a protein linked to zinc regulation, was more active in the skin cells of individuals suffering from psoriasis.
We compared the psoriasis-like symptoms in mice with and without the SLC35E1 gene, particularly after inducing skin inflammation with imiquimod (IMQ). The results showed that mice lacking SLC35E1 had milder symptoms, suggesting this protein directly influences keratinocyte growth.
On a molecular level, we discovered that SLC35E1 affects zinc ion levels in skin cells. When we reduced zinc levels, the symptoms in Slc35e1 mice improved, indicating that managing zinc could be important for treating psoriasis. We also found that patients with psoriasis had lower zinc levels in their skin. Notably, supplementing with zinc helped improve psoriasis-like symptoms in our mouse models.
Overall, this study points to zinc’s crucial role in skin health and suggests that boosting zinc levels may offer new hope for those battling psoriasis.
We compared the psoriasis-like symptoms in mice with and without the SLC35E1 gene, particularly after inducing skin inflammation with imiquimod (IMQ). The results showed that mice lacking SLC35E1 had milder symptoms, suggesting this protein directly influences keratinocyte growth.
On a molecular level, we discovered that SLC35E1 affects zinc ion levels in skin cells. When we reduced zinc levels, the symptoms in Slc35e1 mice improved, indicating that managing zinc could be important for treating psoriasis. We also found that patients with psoriasis had lower zinc levels in their skin. Notably, supplementing with zinc helped improve psoriasis-like symptoms in our mouse models.
Overall, this study points to zinc’s crucial role in skin health and suggests that boosting zinc levels may offer new hope for those battling psoriasis.
Read More
8
Zinc conditioner benefits scalp psoriasis
Efficacy and safety of supramolecular active zinc in the treatment of scalp psoriasis: a multicentre, randomized, observed-blind, parallel-group, placebo- and active-controlled noninferiority trial.
Directly addresses zinc's effectiveness
We delved into the effectiveness of a zinc-based hair conditioner specifically designed for treating scalp psoriasis. This study was a well-structured clinical trial involving 211 participants, where individuals were divided into three groups: those receiving the specialized zinc treatment, a placebo, and a control group given calcipotriol ointment. Remarkably, the trial was multicenter and observed-blind, which adds credibility to the findings.
Our results revealed that the zinc conditioner led to a 39% disease control rate after four weeks, compared to 25% for the placebo and 37% for the calcipotriol ointment group. This means that the zinc treatment significantly outperformed the placebo while being on par with the active control variant. In essence, those using the zinc product experienced better management of their scalp psoriasis than those using a non-active alternative.
Overall, our findings highlight that a supramolecular active zinc antidandruff formulation is not just effective for treating scalp psoriasis but also helps in maintaining results over time and potentially preventing future flare-ups. This offers a promising new avenue for patients seeking relief from this chronic condition.
Our results revealed that the zinc conditioner led to a 39% disease control rate after four weeks, compared to 25% for the placebo and 37% for the calcipotriol ointment group. This means that the zinc treatment significantly outperformed the placebo while being on par with the active control variant. In essence, those using the zinc product experienced better management of their scalp psoriasis than those using a non-active alternative.
Overall, our findings highlight that a supramolecular active zinc antidandruff formulation is not just effective for treating scalp psoriasis but also helps in maintaining results over time and potentially preventing future flare-ups. This offers a promising new avenue for patients seeking relief from this chronic condition.
Read More
7
Zinc inhibits inflammatory responses
Zinc homeostasis regulates caspase activity and inflammasome activation.
Potential treatment requires more clarity
We explored the impact of zinc on psoriasis, a condition often linked with inflammation and immune response. Our attention was drawn to zinc's ability to inhibit inflammasome activation, which can trigger harmful cell death and excessive inflammation.
In particular, we noted how zinc functions as a crucial player in regulating immune responses. By targeting a protein involved in zinc export, called SLC30A1, we observed that increasing zinc levels inside cells could inhibit the activity of caspases, enzymes that play a role in inflammation. This inhibition appears to limit the severity of inflammatory responses, making zinc a potential ally in managing psoriasis and similar conditions.
Interestingly, zinc supplementation showed promise in alleviating symptoms among those with psoriasis, alongside benefits for other inflammatory diseases like sepsis and Alzheimer’s. Although zinc may enhance treatment efficacy, we should remain cautious as the specific benefits for psoriasis treatment relative to other therapies need further clarification.
Overall, zinc emerges as a valuable option worth considering in our approach to treating conditions that involve inflammasome overactivation, including psoriasis.
In particular, we noted how zinc functions as a crucial player in regulating immune responses. By targeting a protein involved in zinc export, called SLC30A1, we observed that increasing zinc levels inside cells could inhibit the activity of caspases, enzymes that play a role in inflammation. This inhibition appears to limit the severity of inflammatory responses, making zinc a potential ally in managing psoriasis and similar conditions.
Interestingly, zinc supplementation showed promise in alleviating symptoms among those with psoriasis, alongside benefits for other inflammatory diseases like sepsis and Alzheimer’s. Although zinc may enhance treatment efficacy, we should remain cautious as the specific benefits for psoriasis treatment relative to other therapies need further clarification.
Overall, zinc emerges as a valuable option worth considering in our approach to treating conditions that involve inflammasome overactivation, including psoriasis.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.7
9.5
Restored sense smell
Magic zinc! Zinc is essential for strengthening the immune system, cell renewal, protein synthesis, collagen formation, and addressing skin issues like psoriasis and acne. After taking zinc picolinate for a month and a half, I noticed remarkable changes: my hair stopped shedding, skin cleared up entirely, and my sense of smell returned after losing it due to Covid. I highly recommend this supplement!
Read More
9.5
Essential assistant
Zinc is my number one assistant for managing psoriasis and stomach gas. The three-month supply is cost-effective, and I highly recommend it due to the high quality provided by Solgar.
8.8
Clearer skin outcome
Zinc Picolinate has been absorbed well by my daughter, who previously took chelated zinc with limited results for her psoriasis. Following Dr. Jonathan Wright's recommendation, we tried this product, and the improvement has been astounding—significant skin repair and better overall condition.
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8.8
Improved psoriasis
My relative suffers from severe psoriasis, covering over 70% of his body. Since he started taking zinc, his face has nearly cleared, and skin lesions on his hands have significantly reduced. He continues treatment under medical supervision, with positive expectations of remission.
8.8
Fights skin problems
A wonderful remedy that strengthens immunity, enhances recovery from colds, improves vision, and treats skin issues such as psoriasis and acne. It also reduces hair loss and improves skin and nails.
