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SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
USERS' SCORE
Good
Based on 1 Reviews
8.6
Top Medical Research Studies
9
Magnesium's potential in neuropathy treatment
Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models.
Strong correlation to neuropathy
A recent study explored the connection between magnesium levels and diabetic sensorimotor polyneuropathy. We measured serum magnesium and plasma methylglyoxal levels in recently diagnosed type 2 diabetes patients—some with neuropathy and others without.
Our findings revealed that patients with neuropathy had significantly lower magnesium levels, which were inversely related to higher methylglyoxal levels. This interaction appeared to contribute to nerve dysfunction, making magnesium's role particularly interesting in the context of neuropathy.
We found that magnesium supplementation could protect nerve cells from the neurotoxic effects of methylglyoxal in laboratory models. Importantly, when magnesium was added, we observed improvements in cell health, suggesting that maintaining magnesium levels might be a promising strategy for mitigating diabetic neuropathy.
Overall, our research highlights a compelling link between magnesium deficiency and nerve damage, suggesting that addressing magnesium levels could hold the key to new treatment approaches for diabetic neuropathy and possibly other neurodegenerative conditions.
Our findings revealed that patients with neuropathy had significantly lower magnesium levels, which were inversely related to higher methylglyoxal levels. This interaction appeared to contribute to nerve dysfunction, making magnesium's role particularly interesting in the context of neuropathy.
We found that magnesium supplementation could protect nerve cells from the neurotoxic effects of methylglyoxal in laboratory models. Importantly, when magnesium was added, we observed improvements in cell health, suggesting that maintaining magnesium levels might be a promising strategy for mitigating diabetic neuropathy.
Overall, our research highlights a compelling link between magnesium deficiency and nerve damage, suggesting that addressing magnesium levels could hold the key to new treatment approaches for diabetic neuropathy and possibly other neurodegenerative conditions.
Read More
8
Transdermal magnesium reduces neuropathic symptoms
Transdermal Magnesium for the Treatment of Peripheral Neuropathy in Chronic Kidney Disease: A Single-Arm, Open-Label Pilot Study.
Direct approach to magnesium treatment
We explored the potential benefits of transdermal magnesium in alleviating peripheral neuropathy among individuals with chronic kidney disease (CKD). The study involved 20 participants from a leading hospital in Sydney, all of whom had advanced CKD. Each person applied a magnesium chloride spray to affected limbs daily over a 12-week period, while we tracked their symptoms using the Neuropathy Total Symptom Score-6 (NTSS-6) at four-week intervals.
Over the study, we observed significant reductions in neuropathic symptoms by weeks 8 and 12 when compared to baseline scores. This suggests that magnesium may effectively lessen the severity of symptoms for those suffering from peripheral neuropathy related to CKD. Interestingly, while symptom relief was noted, serum magnesium levels in participants remained unchanged throughout the study, indicating that the improvement in symptoms might not directly correlate with changes in magnesium concentration.
Overall, our findings suggest a promising potential for transdermal magnesium as a treatment for neuropathy in CKD patients, but further research is necessary to solidify these findings and explore the mechanisms involved.
Over the study, we observed significant reductions in neuropathic symptoms by weeks 8 and 12 when compared to baseline scores. This suggests that magnesium may effectively lessen the severity of symptoms for those suffering from peripheral neuropathy related to CKD. Interestingly, while symptom relief was noted, serum magnesium levels in participants remained unchanged throughout the study, indicating that the improvement in symptoms might not directly correlate with changes in magnesium concentration.
Overall, our findings suggest a promising potential for transdermal magnesium as a treatment for neuropathy in CKD patients, but further research is necessary to solidify these findings and explore the mechanisms involved.
Read More
8
Magnesium mitigates neuropathy effects
Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study.
Significant findings on magnesium's effects
We explored the effects of magnesium on neuropathy related to oxaliplatin, a chemotherapy drug used for colorectal cancer. The study aimed to understand whether magnesium could counteract the activation of microglia, which are immune cells in the brain that can contribute to neuropathic pain. By assessing the antioxidant properties of magnesium, alongside manganese and zinc, we examined their potential to alleviate oxidative stress and other cellular stressors caused by oxaliplatin.
Our findings highlight that magnesium, along with manganese and zinc, successfully prevented the damage to microglial cells typically induced by oxaliplatin. In laboratory tests using the BV-2 microglial cell line, we observed that magnesium reduced both oxidative and endoplasmic reticulum stress. This indicates that magnesium may be a beneficial treatment option for managing neuropathy and protecting nerve cells in patients undergoing chemotherapy.
While the study included other metals, our primary focus was on magnesium’s positive effects, demonstrating its potential role in improving the condition and promoting better nerve health during cancer treatment. We believe these insights could guide further research and clinical application in enhancing patient care.
Our findings highlight that magnesium, along with manganese and zinc, successfully prevented the damage to microglial cells typically induced by oxaliplatin. In laboratory tests using the BV-2 microglial cell line, we observed that magnesium reduced both oxidative and endoplasmic reticulum stress. This indicates that magnesium may be a beneficial treatment option for managing neuropathy and protecting nerve cells in patients undergoing chemotherapy.
While the study included other metals, our primary focus was on magnesium’s positive effects, demonstrating its potential role in improving the condition and promoting better nerve health during cancer treatment. We believe these insights could guide further research and clinical application in enhancing patient care.
Read More
Most Useful Reviews
10
Pain alleviation experienced
This product helps my fibromyalgia and neuropathy. It has cured my sleep issues and achiness, making me feel youthful again. Even my family members, who do not have either condition, find it beneficial when they feel achy. The quality is fantastic, surpassing other brands.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.6
9
Magnesium's potential in neuropathy treatment
Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models.
Strong correlation to neuropathy
A recent study explored the connection between magnesium levels and diabetic sensorimotor polyneuropathy. We measured serum magnesium and plasma methylglyoxal levels in recently diagnosed type 2 diabetes patients—some with neuropathy and others without.
Our findings revealed that patients with neuropathy had significantly lower magnesium levels, which were inversely related to higher methylglyoxal levels. This interaction appeared to contribute to nerve dysfunction, making magnesium's role particularly interesting in the context of neuropathy.
We found that magnesium supplementation could protect nerve cells from the neurotoxic effects of methylglyoxal in laboratory models. Importantly, when magnesium was added, we observed improvements in cell health, suggesting that maintaining magnesium levels might be a promising strategy for mitigating diabetic neuropathy.
Overall, our research highlights a compelling link between magnesium deficiency and nerve damage, suggesting that addressing magnesium levels could hold the key to new treatment approaches for diabetic neuropathy and possibly other neurodegenerative conditions.
Our findings revealed that patients with neuropathy had significantly lower magnesium levels, which were inversely related to higher methylglyoxal levels. This interaction appeared to contribute to nerve dysfunction, making magnesium's role particularly interesting in the context of neuropathy.
We found that magnesium supplementation could protect nerve cells from the neurotoxic effects of methylglyoxal in laboratory models. Importantly, when magnesium was added, we observed improvements in cell health, suggesting that maintaining magnesium levels might be a promising strategy for mitigating diabetic neuropathy.
Overall, our research highlights a compelling link between magnesium deficiency and nerve damage, suggesting that addressing magnesium levels could hold the key to new treatment approaches for diabetic neuropathy and possibly other neurodegenerative conditions.
Read More
9
Magnesium enhances methadone efficacy
Magnesium Salt, a Simple Strategy to Improve Methadone Analgesia in Chronic Pain: An Isobolographic Preclinical Study in Neuropathic Mice.
Moderate relevance due to combination use
We explored how magnesium could enhance the pain relief effects of methadone in a study involving mice with neuropathy. The research focused on whether combining magnesium sulfate with methadone could provide better analgesic benefits compared to methadone alone.
To assess this, we used the formalin test which measures pain responses in a controlled environment. By injecting formalin into the neuropathic limb of these mice, we were able to observe their pain behavior over a set observation period.
The results showed that both magnesium and methadone effectively reduced pain responses on their own. However, the combination of magnesium sulfate and methadone produced a superadditive interaction, meaning they worked better together than expected. This finding suggests that incorporating magnesium could potentially allow for lower doses of methadone, reducing the risk of side effects while improving pain management in neuropathic conditions.
To assess this, we used the formalin test which measures pain responses in a controlled environment. By injecting formalin into the neuropathic limb of these mice, we were able to observe their pain behavior over a set observation period.
The results showed that both magnesium and methadone effectively reduced pain responses on their own. However, the combination of magnesium sulfate and methadone produced a superadditive interaction, meaning they worked better together than expected. This finding suggests that incorporating magnesium could potentially allow for lower doses of methadone, reducing the risk of side effects while improving pain management in neuropathic conditions.
Read More
8
Transdermal magnesium reduces neuropathic symptoms
Transdermal Magnesium for the Treatment of Peripheral Neuropathy in Chronic Kidney Disease: A Single-Arm, Open-Label Pilot Study.
Direct approach to magnesium treatment
We explored the potential benefits of transdermal magnesium in alleviating peripheral neuropathy among individuals with chronic kidney disease (CKD). The study involved 20 participants from a leading hospital in Sydney, all of whom had advanced CKD. Each person applied a magnesium chloride spray to affected limbs daily over a 12-week period, while we tracked their symptoms using the Neuropathy Total Symptom Score-6 (NTSS-6) at four-week intervals.
Over the study, we observed significant reductions in neuropathic symptoms by weeks 8 and 12 when compared to baseline scores. This suggests that magnesium may effectively lessen the severity of symptoms for those suffering from peripheral neuropathy related to CKD. Interestingly, while symptom relief was noted, serum magnesium levels in participants remained unchanged throughout the study, indicating that the improvement in symptoms might not directly correlate with changes in magnesium concentration.
Overall, our findings suggest a promising potential for transdermal magnesium as a treatment for neuropathy in CKD patients, but further research is necessary to solidify these findings and explore the mechanisms involved.
Over the study, we observed significant reductions in neuropathic symptoms by weeks 8 and 12 when compared to baseline scores. This suggests that magnesium may effectively lessen the severity of symptoms for those suffering from peripheral neuropathy related to CKD. Interestingly, while symptom relief was noted, serum magnesium levels in participants remained unchanged throughout the study, indicating that the improvement in symptoms might not directly correlate with changes in magnesium concentration.
Overall, our findings suggest a promising potential for transdermal magnesium as a treatment for neuropathy in CKD patients, but further research is necessary to solidify these findings and explore the mechanisms involved.
Read More
8
Magnesium mitigates neuropathy effects
Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study.
Significant findings on magnesium's effects
We explored the effects of magnesium on neuropathy related to oxaliplatin, a chemotherapy drug used for colorectal cancer. The study aimed to understand whether magnesium could counteract the activation of microglia, which are immune cells in the brain that can contribute to neuropathic pain. By assessing the antioxidant properties of magnesium, alongside manganese and zinc, we examined their potential to alleviate oxidative stress and other cellular stressors caused by oxaliplatin.
Our findings highlight that magnesium, along with manganese and zinc, successfully prevented the damage to microglial cells typically induced by oxaliplatin. In laboratory tests using the BV-2 microglial cell line, we observed that magnesium reduced both oxidative and endoplasmic reticulum stress. This indicates that magnesium may be a beneficial treatment option for managing neuropathy and protecting nerve cells in patients undergoing chemotherapy.
While the study included other metals, our primary focus was on magnesium’s positive effects, demonstrating its potential role in improving the condition and promoting better nerve health during cancer treatment. We believe these insights could guide further research and clinical application in enhancing patient care.
Our findings highlight that magnesium, along with manganese and zinc, successfully prevented the damage to microglial cells typically induced by oxaliplatin. In laboratory tests using the BV-2 microglial cell line, we observed that magnesium reduced both oxidative and endoplasmic reticulum stress. This indicates that magnesium may be a beneficial treatment option for managing neuropathy and protecting nerve cells in patients undergoing chemotherapy.
While the study included other metals, our primary focus was on magnesium’s positive effects, demonstrating its potential role in improving the condition and promoting better nerve health during cancer treatment. We believe these insights could guide further research and clinical application in enhancing patient care.
Read More
7
Magnesium's role in diabetic neuropathy
Unraveling the link between magnesium and diabetic neuropathy: Evidence from in vitro to clinical studies.
Moderate relevance to study findings
We examined the connection between magnesium and diabetic neuropathy (DN), which is a common complication of diabetes leading to nerve damage and pain. Our review looked at various studies, including clinical trials and lab experiments, to get a clearer picture of how magnesium levels impact neuropathy.
The findings suggest that low magnesium levels are often associated with the presence of neuropathy in people with diabetes. We noted that a deficiency in magnesium might accelerate nerve damage through different biological pathways. This raises a significant concern about the role of magnesium in managing neuropathy.
Interestingly, many studies reported that magnesium supplementation could provide protective effects on nerves. This hints at the potential for magnesium to be a helpful addition to treatment strategies for DN in the future. While there’s still some debate about its effectiveness, the cumulative evidence points toward magnesium being a possible alternative or supportive therapy for those suffering from diabetic neuropathy.
The findings suggest that low magnesium levels are often associated with the presence of neuropathy in people with diabetes. We noted that a deficiency in magnesium might accelerate nerve damage through different biological pathways. This raises a significant concern about the role of magnesium in managing neuropathy.
Interestingly, many studies reported that magnesium supplementation could provide protective effects on nerves. This hints at the potential for magnesium to be a helpful addition to treatment strategies for DN in the future. While there’s still some debate about its effectiveness, the cumulative evidence points toward magnesium being a possible alternative or supportive therapy for those suffering from diabetic neuropathy.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Reviews
8.6
10
Pain alleviation experienced
This product helps my fibromyalgia and neuropathy. It has cured my sleep issues and achiness, making me feel youthful again. Even my family members, who do not have either condition, find it beneficial when they feel achy. The quality is fantastic, surpassing other brands.
