' 
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Vitamin B-6 (from pyridoxal-5'-phosphate [Coenzymated™])
335 mcg
20%
Melatonin
5 mg
†
Top Medical Research Studies
9
Melatonin delivery enhances sleep
Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation.
Direct impact on insomnia treatment.
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Read More
9
Melatonin's Potential in Insomnia Treatment
Highly relevant study findings
We aimed to understand the impact of melatonin on insomnia, focusing on its ability to improve sleep quality. The study methodically assessed the isolated effects of melatonin without interference from other treatments. This design allowed us to clearly see how melatonin worked on its own.
Throughout the study, we observed that melatonin could effectively decrease the time it takes to fall asleep and enhance overall sleep duration. Participants reported improvements in their sleep patterns, suggesting that melatonin has a beneficial effect for those struggling with insomnia.
Overall, our exploration into melatonin's influence on insomnia highlights it as a relevant sleep aid. For anyone seeking a natural solution to restless nights, melatonin may indeed offer a promising option.
Throughout the study, we observed that melatonin could effectively decrease the time it takes to fall asleep and enhance overall sleep duration. Participants reported improvements in their sleep patterns, suggesting that melatonin has a beneficial effect for those struggling with insomnia.
Overall, our exploration into melatonin's influence on insomnia highlights it as a relevant sleep aid. For anyone seeking a natural solution to restless nights, melatonin may indeed offer a promising option.
Read More
9
Melatonin enhances sleep and heart health
Unlocking the Heart's Guardian: Exploring Melatonin's Impact on the Cardiovascular System.
Highly relevant to insomnia treatment
We observed how melatonin, often linked to better sleep, shows promising potential beyond just treating insomnia. Recent studies spotlight its effectiveness in promoting restful sleep with minimal side effects, making it a popular choice for people struggling with sleep issues.
Over time, we’ve noticed an uptick in melatonin use in the United States, shifting from 0.08% in 2005-2006 to about 0.28% in 2017-2018. This increase corresponds with growing recognition of melatonin's role in not just managing sleep disorders, but also in supporting muscle recovery and enhancing physical performance.
We also found that individuals with various cardiovascular conditions often have lower melatonin levels, which may contribute to higher risks of heart-related incidents. This connection suggests melatonin may have protective effects on heart health, in addition to its sleep benefits.
Overall, our exploration leads us to conclude that melatonin serves as both a sleep aid and a possible guardian for cardiovascular health, encouraging further research into its multiple benefits.
Over time, we’ve noticed an uptick in melatonin use in the United States, shifting from 0.08% in 2005-2006 to about 0.28% in 2017-2018. This increase corresponds with growing recognition of melatonin's role in not just managing sleep disorders, but also in supporting muscle recovery and enhancing physical performance.
We also found that individuals with various cardiovascular conditions often have lower melatonin levels, which may contribute to higher risks of heart-related incidents. This connection suggests melatonin may have protective effects on heart health, in addition to its sleep benefits.
Overall, our exploration leads us to conclude that melatonin serves as both a sleep aid and a possible guardian for cardiovascular health, encouraging further research into its multiple benefits.
Read More
Most Useful Reviews
9.5
Restored original formula
UPDATE! Source Naturals is reverting to the original formula! I upgraded my review from 1 star to 5 stars after contacting Source Naturals. Their Melatonin had been a lifesaver during my brutal 8-year insomnia battle. After a formula change, I noticed no effect from the new tablets. Thankfully, they plan to return to the previous formula made in-house. It’s a relief, as I depended heavily on melatonin for sleep.
Read More
9.5
Effective for children
I love that these chewable tablets are tolerable for my children. The 1mg dosage is just right for my daughter, who has struggled with insomnia for years. She now falls asleep quickly and sleeps through the night when she takes 1-2 of these before bed.
Read More
9
Long-term success
I've used this product for years with great success for occasional insomnia. I prefer the sublingual form, as it works quickly and doesn't upset my stomach. Initially, I needed the full 5 mg, but with stress resolved, I now only need 2.5 mg occasionally.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.1
9
Vitamin B6 could aid insomnia
A combination of melatonin, vitamin B6 and medicinal plants in the treatment of mild-to-moderate insomnia: A prospective pilot study.
Moderate relevance due to combination
We set out to investigate how vitamin B6 contributes to improving sleep quality in individuals experiencing mild to moderate insomnia. Our study involved 40 participants who were given a combination treatment containing melatonin, vitamin B6, and extracts from various medicinal plants.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
Over a period of two weeks, participants documented their sleep experiences using a daily electronic diary. We analyzed changes in sleep quality, total sleep duration, and how well our treatment reduced sleep-related daytime impairments. Encouragingly, participants reported a significant improvement in sleep quality, with an average score rise from 5.4 to 7.3 on a 10-point scale.
Although it is difficult to isolate the specific effects of vitamin B6 alone due to its use alongside other ingredients, our findings do suggest that this vitamin, when combined with melatonin and plant extracts, could support better sleep. Importantly, the treatment was well-tolerated, with no serious side effects reported.
Overall, while vitamin B6 on its own wasn’t examined, its inclusion in a combination treatment appears to play a role in enhancing sleep quality for those struggling with insomnia.
Read More
9
Melatonin delivery enhances sleep
Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation.
Direct impact on insomnia treatment.
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Read More
9
Melatonin's Potential in Insomnia Treatment
Highly relevant study findings
We aimed to understand the impact of melatonin on insomnia, focusing on its ability to improve sleep quality. The study methodically assessed the isolated effects of melatonin without interference from other treatments. This design allowed us to clearly see how melatonin worked on its own.
Throughout the study, we observed that melatonin could effectively decrease the time it takes to fall asleep and enhance overall sleep duration. Participants reported improvements in their sleep patterns, suggesting that melatonin has a beneficial effect for those struggling with insomnia.
Overall, our exploration into melatonin's influence on insomnia highlights it as a relevant sleep aid. For anyone seeking a natural solution to restless nights, melatonin may indeed offer a promising option.
Throughout the study, we observed that melatonin could effectively decrease the time it takes to fall asleep and enhance overall sleep duration. Participants reported improvements in their sleep patterns, suggesting that melatonin has a beneficial effect for those struggling with insomnia.
Overall, our exploration into melatonin's influence on insomnia highlights it as a relevant sleep aid. For anyone seeking a natural solution to restless nights, melatonin may indeed offer a promising option.
Read More
9
Melatonin enhances sleep and heart health
Unlocking the Heart's Guardian: Exploring Melatonin's Impact on the Cardiovascular System.
Highly relevant to insomnia treatment
We observed how melatonin, often linked to better sleep, shows promising potential beyond just treating insomnia. Recent studies spotlight its effectiveness in promoting restful sleep with minimal side effects, making it a popular choice for people struggling with sleep issues.
Over time, we’ve noticed an uptick in melatonin use in the United States, shifting from 0.08% in 2005-2006 to about 0.28% in 2017-2018. This increase corresponds with growing recognition of melatonin's role in not just managing sleep disorders, but also in supporting muscle recovery and enhancing physical performance.
We also found that individuals with various cardiovascular conditions often have lower melatonin levels, which may contribute to higher risks of heart-related incidents. This connection suggests melatonin may have protective effects on heart health, in addition to its sleep benefits.
Overall, our exploration leads us to conclude that melatonin serves as both a sleep aid and a possible guardian for cardiovascular health, encouraging further research into its multiple benefits.
Over time, we’ve noticed an uptick in melatonin use in the United States, shifting from 0.08% in 2005-2006 to about 0.28% in 2017-2018. This increase corresponds with growing recognition of melatonin's role in not just managing sleep disorders, but also in supporting muscle recovery and enhancing physical performance.
We also found that individuals with various cardiovascular conditions often have lower melatonin levels, which may contribute to higher risks of heart-related incidents. This connection suggests melatonin may have protective effects on heart health, in addition to its sleep benefits.
Overall, our exploration leads us to conclude that melatonin serves as both a sleep aid and a possible guardian for cardiovascular health, encouraging further research into its multiple benefits.
Read More
9
Ramelteon as insomnia treatment
Treatment of Depression-Related Circadian Rhythm Sleep-Wake Disorder (CRSWD) With Melatonin Receptor Agonist Ramelteon: A Case Report.
High relevance to insomnia treatment
We explored how the melatonin receptor agonist ramelteon could help a high school student struggling with delayed sleep-wake phase disorder (DSWPD) coupled with depression. This particular condition is a type of insomnia where the body’s internal clock is out of sync with the external world, often leading to significant challenges in daily life.
The treatment showcased positive outcomes, as the patient experienced improved sleep patterns after using ramelteon. These improvements enabled the student to re-engage with school, achieve university goals, and eventually secure employment after graduation. This case suggests that melatonin could be a valuable option for addressing insomnia, especially in individuals also facing depressive symptoms.
Overall, our observations point to the potential of ramelteon as a promising treatment for those experiencing circadian rhythm sleep disorders alongside depression, emphasizing the need for further clinical exploration in this area.
The treatment showcased positive outcomes, as the patient experienced improved sleep patterns after using ramelteon. These improvements enabled the student to re-engage with school, achieve university goals, and eventually secure employment after graduation. This case suggests that melatonin could be a valuable option for addressing insomnia, especially in individuals also facing depressive symptoms.
Overall, our observations point to the potential of ramelteon as a promising treatment for those experiencing circadian rhythm sleep disorders alongside depression, emphasizing the need for further clinical exploration in this area.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Restored original formula
UPDATE! Source Naturals is reverting to the original formula! I upgraded my review from 1 star to 5 stars after contacting Source Naturals. Their Melatonin had been a lifesaver during my brutal 8-year insomnia battle. After a formula change, I noticed no effect from the new tablets. Thankfully, they plan to return to the previous formula made in-house. It’s a relief, as I depended heavily on melatonin for sleep.
Read More
9.5
Effective for children
I love that these chewable tablets are tolerable for my children. The 1mg dosage is just right for my daughter, who has struggled with insomnia for years. She now falls asleep quickly and sleeps through the night when she takes 1-2 of these before bed.
9
Long-term success
I've used this product for years with great success for occasional insomnia. I prefer the sublingual form, as it works quickly and doesn't upset my stomach. Initially, I needed the full 5 mg, but with stress resolved, I now only need 2.5 mg occasionally.
7.5
Useful for wake-ups
The chewable tablets are perfect for midnight awakenings. Although they don't work alone for my insomnia, they aid me in falling asleep again if I wake during the night. I tried running out once, which confirmed their effectiveness. I will ensure I don't run out again as they truly help with sleep.
Read More
