Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Zinc (as zinc methionine sulfate complex [OptiZinc®])
30 mg
273%
Copper (as copper citrate)
300 mcg
33%
Top Medical Research Studies
8
We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Read More
Most Useful Reviews
0
Caused constipation
1 people found this helpful
The pills are effective; however, they unfortunately caused constipation.
Read More
9
No constipation
The product is of excellent quality and comes in a nice package. It is very useful for the gut and microbiome, and I experienced no constipation. The taste is acceptable, and I appreciate the quality ingredients.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
0
Caused constipation
1 people found this helpful
The pills are effective; however, they unfortunately caused constipation.
Read More
9
No constipation
The product is of excellent quality and comes in a nice package. It is very useful for the gut and microbiome, and I experienced no constipation. The taste is acceptable, and I appreciate the quality ingredients.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Nacci C, Fanelli M, Potenza MA, Leo V, Montagnani M, et al. Carbon monoxide contributes to the constipating effects of granisetron in rat colon. World J Gastroenterol. 2016;22:9333.
