Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.6
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Wild Caught Fish Oil Concentrate
1250 mg
†
Total Omega-3 Fatty Acids as TG
1055 mg
†
EPA (Eicosapentaenoic Acid)
690 mg
†
DHA (Docosahexaenoic Acid)
310 mg
†
Other Omega-3 Fatty Acids
55 mg
†
Top Medical Research Studies
9
We explored the effects of eicosapentaenoic acid, a type of omega-3 fatty acid, on pancreatic cancer using a specially designed mouse model that closely mimics human disease. This model allowed us to examine how adding omega-3 to the diet could impact cancer progression.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
Read More
8
We explored how eicosapentaenoic acid (EPA), a type of dietary polyunsaturated fatty acid, affects cancer, specifically focusing on colorectal cancer (CRC). In our research, we investigated five different CRC cell lines to see how EPA and two other fatty acids—docosahexaenoic acid (DHA) and linoleic acid (LA)—impact the methylation of the PPARγ promoter, as well as the expression of PPARγ and COX2.
Our findings revealed that EPA has a significant role in modifying PPARγ promoter methylation and subsequently influences gene expression. Especially notable was the discovery that DHA exhibited a stronger effect in promoting the expression of PPARγ while decreasing COX2 levels across various cell lines. This suggests that EPA, along with DHA and LA, has the potential to alter cancer-related gene activity in CRC cells, which could be essential for therapeutic strategies.
The observed changes in PPARγ and COX2 are particularly intriguing as they might contribute to understanding how dietary fats can impact cancer growth and progression. Overall, this research highlights the potential therapeutic benefits of using polyunsaturated fatty acids like EPA in colorectal cancer treatment.
Our findings revealed that EPA has a significant role in modifying PPARγ promoter methylation and subsequently influences gene expression. Especially notable was the discovery that DHA exhibited a stronger effect in promoting the expression of PPARγ while decreasing COX2 levels across various cell lines. This suggests that EPA, along with DHA and LA, has the potential to alter cancer-related gene activity in CRC cells, which could be essential for therapeutic strategies.
The observed changes in PPARγ and COX2 are particularly intriguing as they might contribute to understanding how dietary fats can impact cancer growth and progression. Overall, this research highlights the potential therapeutic benefits of using polyunsaturated fatty acids like EPA in colorectal cancer treatment.
Read More
8
Eicosapentaenoic acid aids breast cancer
We conducted a comprehensive 12-month trial focusing on how eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplementation affects breast cancer in women with hormone receptor-negative (ERPR-) subtypes. Specifically, we assessed the impacts of doses ranging from 1 to 5 grams per day of EPA plus DHA on breast adipose tissue.
Throughout this double-blind, randomized study, we collected blood and breast adipose samples every three months to analyze various biomarker effects. Our findings revealed that higher doses of EPA and DHA significantly increased the concentrations of these essential fatty acids and their beneficial oxylipin metabolites.
Interestingly, we also noted that these changes produce noticeable shifts in DNA methylation, particularly in gene promoters that are crucial to the metabolism pathways associated with ERPR- breast cancer development. This suggests that dietary n-3 fatty acids, like EPA and DHA, may not only influence metabolic processes but also lead to epigenetic changes, potentially acting as a preventive measure against this aggressive cancer type.
Throughout this double-blind, randomized study, we collected blood and breast adipose samples every three months to analyze various biomarker effects. Our findings revealed that higher doses of EPA and DHA significantly increased the concentrations of these essential fatty acids and their beneficial oxylipin metabolites.
Interestingly, we also noted that these changes produce noticeable shifts in DNA methylation, particularly in gene promoters that are crucial to the metabolism pathways associated with ERPR- breast cancer development. This suggests that dietary n-3 fatty acids, like EPA and DHA, may not only influence metabolic processes but also lead to epigenetic changes, potentially acting as a preventive measure against this aggressive cancer type.
Read More
Most Useful Reviews
9
Essential for family
Due to my family's struggles with cancer, I need to take high doses of fish oil, particularly those rich in EPA. Just one fish oil a day is manageable, especially for the elderly, and it is in an easily absorbed Tg form. I highly recommend it.
Read More
8.5
Effective dosage
This high-unit Omega-3 fish oil has no unpleasant smell and is enriched with EPA for its anti-inflammatory and anti-cancer benefits. I find that taking 1-2 capsules daily is very effective, and the DHA aids in preventing dry eyes. It’s a product I continuously repurchase.
Read More
7.5
Joint pain reduction
I have been taking Sports Research Fish Oil for a few months and have noticed significant improvements in my heart health and inflammation. Omega-3 reduces inflammation and can lower the risk of chronic diseases like heart disease and cancer. Since starting this supplement, I have experienced reduced joint pain and stiffness, improving my overall well-being. This high-quality, organic fish oil is part of my wellness program, and I highly recommend it for heart health and inflammation reduction.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.6
- All Researches
9.5
Omega-3 fatty acids inhibit tumors
We conducted a study to explore the effects of high doses of omega-3 fatty acids—specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—on tumor formation in a model of neuroblastoma, a challenging pediatric cancer. Using a syngeneic mouse model, we administered these fatty acids at doses equivalent to those safely tolerable in humans.
After the gavage, we introduced neuro-2a cells that were prone to tumor development. Our observations revealed that both DHA and EPA completely halted tumor formation in the treated mice, in stark contrast to the control group where half of the mice did develop tumors. Intriguingly, we also noticed that arachidonic acid (another fatty acid) actually promoted tumor growth, suggesting that it might counteract the positive effects of EPA.
Overall, these findings indicate that ultra-high doses of omega-3 fatty acids, particularly DHA and EPA, could offer a promising, low-toxicity treatment for neuroblastoma by blocking tumorigenesis. This research highlights the potential for incorporating dietary fatty acids into cancer therapies, especially for high-risk pediatric patients who currently face limited options.
After the gavage, we introduced neuro-2a cells that were prone to tumor development. Our observations revealed that both DHA and EPA completely halted tumor formation in the treated mice, in stark contrast to the control group where half of the mice did develop tumors. Intriguingly, we also noticed that arachidonic acid (another fatty acid) actually promoted tumor growth, suggesting that it might counteract the positive effects of EPA.
Overall, these findings indicate that ultra-high doses of omega-3 fatty acids, particularly DHA and EPA, could offer a promising, low-toxicity treatment for neuroblastoma by blocking tumorigenesis. This research highlights the potential for incorporating dietary fatty acids into cancer therapies, especially for high-risk pediatric patients who currently face limited options.
Read More
9
We explored the effects of eicosapentaenoic acid, a type of omega-3 fatty acid, on pancreatic cancer using a specially designed mouse model that closely mimics human disease. This model allowed us to examine how adding omega-3 to the diet could impact cancer progression.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
Read More
9
We developed a special hydrogel that mixes different components including eicosapentaenoic acid (EPA) to study its effects on cancer treatment. The hydrogel helps target the tumor environment more effectively due to its unique structure.
In our exploration, we noted that this hydrogel encouraged processes like lipid peroxidation and the production of reactive oxygen species, which are known to trigger a type of cell death called ferroptosis. Additionally, it promoted apoptosis, another way cancer cells can die, and supported an immune response in the tumor area.
As we observed, the hydrogel not only worked well in laboratory tests but also showed significant promise in reducing both primary tumors and metastatic growth in live models. This suggests that EPA can play a notable role when combined with innovative treatments, paving the way for better immune responses against tumors.
However, it is essential to highlight that since the study combined EPA with multiple components, isolating its individual impact might be challenging. Thus, while our findings are promising, we must approach the specific benefits of EPA cautiously as part of this comprehensive treatment strategy.
In our exploration, we noted that this hydrogel encouraged processes like lipid peroxidation and the production of reactive oxygen species, which are known to trigger a type of cell death called ferroptosis. Additionally, it promoted apoptosis, another way cancer cells can die, and supported an immune response in the tumor area.
As we observed, the hydrogel not only worked well in laboratory tests but also showed significant promise in reducing both primary tumors and metastatic growth in live models. This suggests that EPA can play a notable role when combined with innovative treatments, paving the way for better immune responses against tumors.
However, it is essential to highlight that since the study combined EPA with multiple components, isolating its individual impact might be challenging. Thus, while our findings are promising, we must approach the specific benefits of EPA cautiously as part of this comprehensive treatment strategy.
Read More
9
We focused our research on the potential of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, particularly its derivatives known as specialized pro-resolving mediators (SPMs). These mediators have shown promise in playing a role in the resolution of inflammation, which is crucial in various health conditions, including cancer.
Our observations highlight how SPMs, derived from EPA, exhibit powerful effects in reducing inflammation and can influence cancer cell behavior. Specifically, we noted that these mediators help decrease the proliferation and metastasis of cancer cells, which may lead to slower tumor growth.
Evidence suggests that EPA derivatives, such as Resolvins, not only help in controlling immune cell functions but also aid in clearing out debris in tumor environments. This clearing process can potentially enhance therapeutic outcomes by making the area less conducive to tumor progression.
Altogether, our findings contribute to the idea that EPA has compelling implications for helping manage cancer more effectively, particularly through its ability to modulate the inflammatory response in the body.
Our observations highlight how SPMs, derived from EPA, exhibit powerful effects in reducing inflammation and can influence cancer cell behavior. Specifically, we noted that these mediators help decrease the proliferation and metastasis of cancer cells, which may lead to slower tumor growth.
Evidence suggests that EPA derivatives, such as Resolvins, not only help in controlling immune cell functions but also aid in clearing out debris in tumor environments. This clearing process can potentially enhance therapeutic outcomes by making the area less conducive to tumor progression.
Altogether, our findings contribute to the idea that EPA has compelling implications for helping manage cancer more effectively, particularly through its ability to modulate the inflammatory response in the body.
Read More
9
We assessed the effectiveness of docosahexaenoic acid (DHA) in treating cancer, specifically in various rodent models of hepatocellular carcinoma (HCC). The study utilized weighted amide proton transfer (APT) MRI to monitor tumor response in three different HCC models: diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft, and human HepG2 ectopic xenograft.
Our findings revealed that all HCC models exhibited a markedly higher APT signal compared to surrounding normal tissues. This increased signal allowed us to distinguish between malignant HCC lesions and benign nodules specifically in the DEN model.
By administering low-density lipoprotein docosahexaenoic acid (LDL-DHA) nanoparticles directly to N1S1 xenografts, we observed a significant reduction in tumor APT signal within just 72 hours. Similarly, direct injections into HepG2 xenografts demonstrated comparable therapeutic effects. Overall, this study showcases the potential of APT imaging in the diagnostic and therapeutic management of HCC, particularly highlighting DHA's effectiveness delivered via nanoparticles.
Our findings revealed that all HCC models exhibited a markedly higher APT signal compared to surrounding normal tissues. This increased signal allowed us to distinguish between malignant HCC lesions and benign nodules specifically in the DEN model.
By administering low-density lipoprotein docosahexaenoic acid (LDL-DHA) nanoparticles directly to N1S1 xenografts, we observed a significant reduction in tumor APT signal within just 72 hours. Similarly, direct injections into HepG2 xenografts demonstrated comparable therapeutic effects. Overall, this study showcases the potential of APT imaging in the diagnostic and therapeutic management of HCC, particularly highlighting DHA's effectiveness delivered via nanoparticles.
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User Reviews
USERS' SCORE
Moderately Good
Based on 5 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Essential for family
Due to my family's struggles with cancer, I need to take high doses of fish oil, particularly those rich in EPA. Just one fish oil a day is manageable, especially for the elderly, and it is in an easily absorbed Tg form. I highly recommend it.
Read More
8.5
Effective dosage
This high-unit Omega-3 fish oil has no unpleasant smell and is enriched with EPA for its anti-inflammatory and anti-cancer benefits. I find that taking 1-2 capsules daily is very effective, and the DHA aids in preventing dry eyes. It’s a product I continuously repurchase.
Read More
7.5
Joint pain reduction
I have been taking Sports Research Fish Oil for a few months and have noticed significant improvements in my heart health and inflammation. Omega-3 reduces inflammation and can lower the risk of chronic diseases like heart disease and cancer. Since starting this supplement, I have experienced reduced joint pain and stiffness, improving my overall well-being. This high-quality, organic fish oil is part of my wellness program, and I highly recommend it for heart health and inflammation reduction.
Read More
4
Anti-inflammatory benefits
Omega-3 is a remarkable nutrient with a wide range of potential health benefits. Found in fatty fish, nuts, and seeds, it has anti-inflammatory properties that may help lower the risk of chronic diseases, including heart disease and cancer. Additionally, omega-3 plays a crucial role in brain health, improving cognitive function, mood, and memory. It may benefit joint, eye, and skin health. Overall, omega-3 can significantly impact health and well-being.
Read More
5
Reduces disease risk
Omega-3 fatty acids effectively improve cell insulin sensitivity, reduce inflammation, and decrease cardiovascular disease risk factors in those with metabolic syndrome. They play a role in decreasing chronic inflammation, which can lead to heart disease, cancer, and other serious illnesses.
Read More
Frequently Asked Questions
7.5
Joint pain reduction
I have been taking Sports Research Fish Oil for a few months and have noticed significant improvements in my heart health and inflammation. Omega-3 reduces inflammation and can lower the risk of chronic diseases like heart disease and cancer. Since starting this supplement, I have experienced reduced joint pain and stiffness, improving my overall well-being. This high-quality, organic fish oil is part of my wellness program, and I highly recommend it for heart health and inflammation reduction.
4
Anti-inflammatory benefits
Omega-3 is a remarkable nutrient with a wide range of potential health benefits. Found in fatty fish, nuts, and seeds, it has anti-inflammatory properties that may help lower the risk of chronic diseases, including heart disease and cancer. Additionally, omega-3 plays a crucial role in brain health, improving cognitive function, mood, and memory. It may benefit joint, eye, and skin health. Overall, omega-3 can significantly impact health and well-being.
8.5
Effective dosage
This high-unit Omega-3 fish oil has no unpleasant smell and is enriched with EPA for its anti-inflammatory and anti-cancer benefits. I find that taking 1-2 capsules daily is very effective, and the DHA aids in preventing dry eyes. It’s a product I continuously repurchase.
9
Essential for family
Due to my family's struggles with cancer, I need to take high doses of fish oil, particularly those rich in EPA. Just one fish oil a day is manageable, especially for the elderly, and it is in an easily absorbed Tg form. I highly recommend it.
5
Reduces disease risk
Omega-3 fatty acids effectively improve cell insulin sensitivity, reduce inflammation, and decrease cardiovascular disease risk factors in those with metabolic syndrome. They play a role in decreasing chronic inflammation, which can lead to heart disease, cancer, and other serious illnesses.
8
We explored how eicosapentaenoic acid (EPA), a type of dietary polyunsaturated fatty acid, affects cancer, specifically focusing on colorectal cancer (CRC). In our research, we investigated five different CRC cell lines to see how EPA and two other fatty acids—docosahexaenoic acid (DHA) and linoleic acid (LA)—impact the methylation of the PPARγ promoter, as well as the expression of PPARγ and COX2.
Our findings revealed that EPA has a significant role in modifying PPARγ promoter methylation and subsequently influences gene expression. Especially notable was the discovery that DHA exhibited a stronger effect in promoting the expression of PPARγ while decreasing COX2 levels across various cell lines. This suggests that EPA, along with DHA and LA, has the potential to alter cancer-related gene activity in CRC cells, which could be essential for therapeutic strategies.
The observed changes in PPARγ and COX2 are particularly intriguing as they might contribute to understanding how dietary fats can impact cancer growth and progression. Overall, this research highlights the potential therapeutic benefits of using polyunsaturated fatty acids like EPA in colorectal cancer treatment.
Our findings revealed that EPA has a significant role in modifying PPARγ promoter methylation and subsequently influences gene expression. Especially notable was the discovery that DHA exhibited a stronger effect in promoting the expression of PPARγ while decreasing COX2 levels across various cell lines. This suggests that EPA, along with DHA and LA, has the potential to alter cancer-related gene activity in CRC cells, which could be essential for therapeutic strategies.
The observed changes in PPARγ and COX2 are particularly intriguing as they might contribute to understanding how dietary fats can impact cancer growth and progression. Overall, this research highlights the potential therapeutic benefits of using polyunsaturated fatty acids like EPA in colorectal cancer treatment.
The seAFOod trial looked at how eicosapentaenoic acid (EPA)—a type of omega-3 fatty acid—could help prevent colorectal polyps, which are precursors to colon cancer. The study was a randomized controlled trial that included various dietary and supplemental sources of omega-3s.
We examined the total intake of omega-3s, as well as their concentrations in red blood cells and rectal mucosa, to see how they related to polyp recurrence rates. By focusing on the changes in EPA levels rather than treatment types, we discovered that higher EPA concentrations in the body were associated with a reduced risk of polyps recurring.
This finding is important as it suggests that increasing EPA intake could be a beneficial strategy for colorectal cancer prevention. However, we were careful to evaluate both dietary intake and compliance with EPA capsules to ensure the results were accurate and reliable.
We examined the total intake of omega-3s, as well as their concentrations in red blood cells and rectal mucosa, to see how they related to polyp recurrence rates. By focusing on the changes in EPA levels rather than treatment types, we discovered that higher EPA concentrations in the body were associated with a reduced risk of polyps recurring.
This finding is important as it suggests that increasing EPA intake could be a beneficial strategy for colorectal cancer prevention. However, we were careful to evaluate both dietary intake and compliance with EPA capsules to ensure the results were accurate and reliable.
9.5
Omega-3 fatty acids inhibit tumors
We conducted a study to explore the effects of high doses of omega-3 fatty acids—specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—on tumor formation in a model of neuroblastoma, a challenging pediatric cancer. Using a syngeneic mouse model, we administered these fatty acids at doses equivalent to those safely tolerable in humans.
After the gavage, we introduced neuro-2a cells that were prone to tumor development. Our observations revealed that both DHA and EPA completely halted tumor formation in the treated mice, in stark contrast to the control group where half of the mice did develop tumors. Intriguingly, we also noticed that arachidonic acid (another fatty acid) actually promoted tumor growth, suggesting that it might counteract the positive effects of EPA.
Overall, these findings indicate that ultra-high doses of omega-3 fatty acids, particularly DHA and EPA, could offer a promising, low-toxicity treatment for neuroblastoma by blocking tumorigenesis. This research highlights the potential for incorporating dietary fatty acids into cancer therapies, especially for high-risk pediatric patients who currently face limited options.
After the gavage, we introduced neuro-2a cells that were prone to tumor development. Our observations revealed that both DHA and EPA completely halted tumor formation in the treated mice, in stark contrast to the control group where half of the mice did develop tumors. Intriguingly, we also noticed that arachidonic acid (another fatty acid) actually promoted tumor growth, suggesting that it might counteract the positive effects of EPA.
Overall, these findings indicate that ultra-high doses of omega-3 fatty acids, particularly DHA and EPA, could offer a promising, low-toxicity treatment for neuroblastoma by blocking tumorigenesis. This research highlights the potential for incorporating dietary fatty acids into cancer therapies, especially for high-risk pediatric patients who currently face limited options.
7
We explored the potential benefits of eicosapentaenoic acid (EPA), a type of omega-3 long-chain polyunsaturated fatty acid, in the context of lung cancer. The study found that EPA can play a significant role by modifying the tumor microenvironment, promoting cancer cell apoptosis (or programmed cell death), and inducing autophagy, which helps the body clear damaged cells.
Although we noted that EPA is often combined with other therapeutic strategies, it is recognized for its ability to improve the nutritional status of cancer patients and enhance the effectiveness of traditional treatments. This makes EPA an attractive option in the nutritional management of cancer, aiming to alleviate complications and potentially boost the response to therapy.
While researchers have yet to fully decipher the exact anti-cancer mechanisms of EPA, its promising effects on tumor suppression and patient well-being highlight its importance as a dietary supplement in lung cancer care. Overall, there's a growing recognition of how including omega-3 fatty acids like EPA in treatment plans can be beneficial for patients battling this challenging disease.
Although we noted that EPA is often combined with other therapeutic strategies, it is recognized for its ability to improve the nutritional status of cancer patients and enhance the effectiveness of traditional treatments. This makes EPA an attractive option in the nutritional management of cancer, aiming to alleviate complications and potentially boost the response to therapy.
While researchers have yet to fully decipher the exact anti-cancer mechanisms of EPA, its promising effects on tumor suppression and patient well-being highlight its importance as a dietary supplement in lung cancer care. Overall, there's a growing recognition of how including omega-3 fatty acids like EPA in treatment plans can be beneficial for patients battling this challenging disease.
4
We explored the effects of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, particularly its potential role in cancer treatments. By exposing human red blood cells to anticancer concentrations of EPA for 24 hours, we aimed to better understand how it might impact cell health.
Our findings revealed that EPA led to increased hemolysis and eryptosis, which is a form of programmed cell death in red blood cells. We observed that the presence of EPA triggered calcium buildup in the cells and inhibited the activity of acetylcholinesterase, an enzyme crucial for cell function, suggesting a pathway through which EPA exerts its effects.
Furthermore, in our tests, certain compounds like urea and potassium chloride were able to reduce the damage caused by EPA, indicating potential methods to mitigate its negative impacts while pursuing its anticancer benefits. Overall, the study highlights the complex balance between the anticancer capabilities of EPA and its possible drawbacks on healthy red blood cells.
Although EPA is celebrated for its potential in cancer therapy, this study underscores the necessity for caution due to its impacts on red blood cells, particularly during chemotherapy, where every detail matters. Future research might benefit from exploring ways to harness EPA's cancer-fighting properties while minimizing harm to healthy cells.
Our findings revealed that EPA led to increased hemolysis and eryptosis, which is a form of programmed cell death in red blood cells. We observed that the presence of EPA triggered calcium buildup in the cells and inhibited the activity of acetylcholinesterase, an enzyme crucial for cell function, suggesting a pathway through which EPA exerts its effects.
Furthermore, in our tests, certain compounds like urea and potassium chloride were able to reduce the damage caused by EPA, indicating potential methods to mitigate its negative impacts while pursuing its anticancer benefits. Overall, the study highlights the complex balance between the anticancer capabilities of EPA and its possible drawbacks on healthy red blood cells.
Although EPA is celebrated for its potential in cancer therapy, this study underscores the necessity for caution due to its impacts on red blood cells, particularly during chemotherapy, where every detail matters. Future research might benefit from exploring ways to harness EPA's cancer-fighting properties while minimizing harm to healthy cells.
8
We focused on understanding how eicosapentaenoic acid (EPA) impacts cancer treatment and outcomes, particularly in women diagnosed with breast cancer. Our review highlighted the role of EPA, a type of omega-3 fatty acid, in potentially modifying cancer cell behavior and enhancing responses to treatments.
The findings indicated that specific unsaturated fats like EPA show promise in having anti-cancer properties. These effects are believed to arise from their ability to influence the cellular processes in cancer and fight inflammation, which can be crucial during cancer management.
Additionally, we noted that adhering to a Mediterranean diet, which is rich in antioxidants and healthy fats, could support cancer recovery and improve overall quality of life for patients. This highlights the potential benefits of dietary choices in the long-term management of breast cancer.
However, while EPA and other dietary components may contribute positively to cancer treatments, further research is necessary to fully understand their effectiveness and the best ways to incorporate them into treatment plans.
The findings indicated that specific unsaturated fats like EPA show promise in having anti-cancer properties. These effects are believed to arise from their ability to influence the cellular processes in cancer and fight inflammation, which can be crucial during cancer management.
Additionally, we noted that adhering to a Mediterranean diet, which is rich in antioxidants and healthy fats, could support cancer recovery and improve overall quality of life for patients. This highlights the potential benefits of dietary choices in the long-term management of breast cancer.
However, while EPA and other dietary components may contribute positively to cancer treatments, further research is necessary to fully understand their effectiveness and the best ways to incorporate them into treatment plans.
References
- Elçi MP, Fatsa T, Ören S, Miser Salihoğlu E, Akaydın S. Investigation of the Effects of Polyunsaturated Fatty Acid Ratios in Human SH-SY5Y Cells by Methods. Turk J Pharm Sci. 2025;22:10. doi:10.4274/tjps.galenos.2024.40583
- Babaeenezhad E, Khosravi P, Moradi Sarabi M. Dietary polyunsaturated fatty acids affect PPARγ promoter methylation status and regulate the PPARγ/COX2 pathway in some colorectal cancer cell lines. Genes Nutr. 2025;20:2. doi:10.1186/s12263-025-00764-x
- Patel V, Li YN, Benhamou LE, Park HG, Raleigh M, et al. Ultra-High Dose Oral ω3 Eicosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA), or Oxidation-Resistant Deuterated DHA Block Tumorigenesis in a -Driven Neuroblastoma Model. Cancers (Basel). 2025;17. doi:10.3390/cancers17030362
- Alharthy FH, Alsughayyir J, Alfhili MA. Eicosapentaenoic Acid Triggers Phosphatidylserine Externalization in the Erythrocyte Membrane through Calcium Signaling and Anticholinesterase Activity. Physiol Res. 2024;73:1075.
- Sun R, Zhang Y, Zhao X, Tang T, Cao Y, et al. Temporal and Spatial Metabolic Shifts Revealing the Transition from Ulcerative Colitis to Colitis-Associated Colorectal Cancer. Adv Sci (Weinh). 2025. doi:10.1002/advs.202412551
- Luo J, Peng S, Jiang Z, Wang Q, Zhang M, et al. Roles and therapeutic opportunities of ω-3 long-chain polyunsaturated fatty acids in lung cancer. iScience. 2025;28:111601. doi:10.1016/j.isci.2024.111601
- Garay MI, Mazo T, Ferrero V, Barotto NN, Lagares C, et al. Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression. Carcinogenesis. 2025;46. doi:10.1093/carcin/bgae081
- Sun G, Fuller H, Fenton H, Race AD, Downing A, et al. The Relationship Between Dietary and Supplemental omega-3 Highly Unsaturated Fatty Acid Intake, Blood and Tissue omega-3 Highly Unsaturated Fatty Acid Concentrations, and Colorectal Polyp Recurrence: A Secondary Analysis of the seAFOod Polyp Prevention Trial. J Nutr. 2025;155:549. doi:10.1016/j.tjnut.2024.12.004
- Frankhouser DE, DeWess T, Snodgrass IF, Cole RM, Steck S, et al. Randomized dose-response trial of n-3 fatty acids in hormone receptor negative breast cancer survivors- impact on breast adipose oxylipin and DNA methylation patterns. medRxiv. 2024. doi:10.1101/2024.09.16.24313691
- Ormiston K, Fitzgerald J, Andridge R, Lustberg MB, DeVries AC, et al. Low sucrose diets protect long-term memory and EPA & DHA enriched diets alter insulin resistance in a mouse model of chemotherapy. Nutr Res. 2024;131:39. doi:10.1016/j.nutres.2024.09.004
- Ormiston K, Melink Z, Andridge R, Lustberg M, Courtney DeVries A, et al. Dietary EPA and DHA enrichment of a high fat diet during doxorubicin-based chemotherapy attenuated neuroinflammatory gene expression in the brain of C57bl/6 ovariectomized mice. Brain Behav Immun. 2025;123:370. doi:10.1016/j.bbi.2024.09.021
- Chua AV, Hernandez ARB, Mendoza MJL, San Juan MD. Omega-3 Fatty Acids Increase Weight and Quality of Life Scores in Patients With Advanced Non-Small Cell Lung Cancer and Cancer Cachexia: A Meta-Analysis. Integr Cancer Ther. 2024;23:15347354241275052. doi:10.1177/15347354241275052
- Virani S, Afreen S, Perthiani A, Sangster E, Lanka N, et al. The Impact of Dietary Unsaturated Fat or the Mediterranean Diet on Women Diagnosed With Breast Cancer: A Systematic Review. Cureus. 2024;16:e65362. doi:10.7759/cureus.65362
- Gholamalizadeh M, Tajadod S, Majidi N, Aghakhaninejad Z, Mahmoudi Z, et al. Associations between diet and nutritional supplements and colorectal cancer: A systematic review. JGH Open. 2024;8:e13108. doi:10.1002/jgh3.13108
- Chen X, Jiang T, Li Y, Zhang Y, Chen J, et al. Carrageenan-ferrocene-eicosapentaenoic acid composite hydrogel induce ferroptosis and apoptosis for anti-tumor recurrence and metastasis. Int J Biol Macromol. 2024;276:133942. doi:10.1016/j.ijbiomac.2024.133942
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