' 
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
USERS' SCORE
Good
Based on 5 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Wild Caught Fish Oil Concentrate
1250 mg
†
Total Omega-3 Fatty Acids as TG
1055 mg
†
EPA (Eicosapentaenoic Acid)
690 mg
†
DHA (Docosahexaenoic Acid)
310 mg
†
Other Omega-3 Fatty Acids
55 mg
†
Top Medical Research Studies
9
Impact of Omega-3 on Cancer
Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression.
Highly relevant cancer treatment insights
We explored the effects of eicosapentaenoic acid, a type of omega-3 fatty acid, on pancreatic cancer using a specially designed mouse model that closely mimics human disease. This model allowed us to examine how adding omega-3 to the diet could impact cancer progression.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
Read More
9
DHA affects colorectal cancer pathways
Dietary polyunsaturated fatty acids affect PPARγ promoter methylation status and regulate the PPARγ/COX2 pathway in some colorectal cancer cell lines.
Study focuses on DHA's effects
We set out to explore how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, affects colorectal cancer (CRC) cells. In this study, we treated five different colorectal cancer cell lines with varying concentrations of DHA, along with other fatty acids like eicosapentaenoic acid (EPA) and linoleic acid (LA). This allowed us to see if DHA could impact the methylation patterns of the PPARγ promoter, a key player in cancer regulation, and affect the relationship between PPARγ and COX2, two important molecules involved in cancer growth.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
Our findings revealed that DHA significantly altered the methylation status in some cell lines, effectively demethylating specific regions of the PPARγ promoter. We observed that this demethylation was linked to an increase in the expression of PPARγ in cells where it was hemimethylated. Interestingly, DHA not only boosted PPARγ levels but also downregulated COX2 across all CRC cell lines tested. This suggests that DHA might have a role in reducing inflammatory signals linked to cancer progression.
The overall impact seemed to vary depending on the type of cancer cell we were working with, indicating a cell type-dependent effect of DHA. Notably, we found that DHA was more effective than EPA or LA in modulating the PPARγ promoter. This research shows promising potential for DHA in colorectal cancer treatment and highlights its importance in dietary considerations for cancer management.
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8
Eicosapentaenoic acid in CRC treatment
Dietary polyunsaturated fatty acids affect PPARγ promoter methylation status and regulate the PPARγ/COX2 pathway in some colorectal cancer cell lines.
Supports PUFA role in cancer
We explored how eicosapentaenoic acid (EPA), a type of dietary polyunsaturated fatty acid, affects cancer, specifically focusing on colorectal cancer (CRC). In our research, we investigated five different CRC cell lines to see how EPA and two other fatty acids—docosahexaenoic acid (DHA) and linoleic acid (LA)—impact the methylation of the PPARγ promoter, as well as the expression of PPARγ and COX2.
Our findings revealed that EPA has a significant role in modifying PPARγ promoter methylation and subsequently influences gene expression. Especially notable was the discovery that DHA exhibited a stronger effect in promoting the expression of PPARγ while decreasing COX2 levels across various cell lines. This suggests that EPA, along with DHA and LA, has the potential to alter cancer-related gene activity in CRC cells, which could be essential for therapeutic strategies.
The observed changes in PPARγ and COX2 are particularly intriguing as they might contribute to understanding how dietary fats can impact cancer growth and progression. Overall, this research highlights the potential therapeutic benefits of using polyunsaturated fatty acids like EPA in colorectal cancer treatment.
Our findings revealed that EPA has a significant role in modifying PPARγ promoter methylation and subsequently influences gene expression. Especially notable was the discovery that DHA exhibited a stronger effect in promoting the expression of PPARγ while decreasing COX2 levels across various cell lines. This suggests that EPA, along with DHA and LA, has the potential to alter cancer-related gene activity in CRC cells, which could be essential for therapeutic strategies.
The observed changes in PPARγ and COX2 are particularly intriguing as they might contribute to understanding how dietary fats can impact cancer growth and progression. Overall, this research highlights the potential therapeutic benefits of using polyunsaturated fatty acids like EPA in colorectal cancer treatment.
Read More
Most Useful Reviews
9.5
Essential for family
Due to my family's struggles with cancer, I need to take high doses of fish oil, particularly those rich in EPA. Just one fish oil a day is manageable, especially for the elderly, and it is in an easily absorbed Tg form. I highly recommend it.
Read More
9.3
Effective dosage
This high-unit Omega-3 fish oil has no unpleasant smell and is enriched with EPA for its anti-inflammatory and anti-cancer benefits. I find that taking 1-2 capsules daily is very effective, and the DHA aids in preventing dry eyes. It’s a product I continuously repurchase.
Read More
8.8
Joint pain reduction
I have been taking Sports Research Fish Oil for a few months and have noticed significant improvements in my heart health and inflammation. Omega-3 reduces inflammation and can lower the risk of chronic diseases like heart disease and cancer. Since starting this supplement, I have experienced reduced joint pain and stiffness, improving my overall well-being. This high-quality, organic fish oil is part of my wellness program, and I highly recommend it for heart health and inflammation reduction.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
- All Researches
9.5
Omega-3 fatty acids inhibit tumors
Ultra-High Dose Oral ω3 Eicosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA), or Oxidation-Resistant Deuterated DHA Block Tumorigenesis in a -Driven Neuroblastoma Model.
Strong link to cancer treatment
We conducted a study to explore the effects of high doses of omega-3 fatty acids—specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—on tumor formation in a model of neuroblastoma, a challenging pediatric cancer. Using a syngeneic mouse model, we administered these fatty acids at doses equivalent to those safely tolerable in humans.
After the gavage, we introduced neuro-2a cells that were prone to tumor development. Our observations revealed that both DHA and EPA completely halted tumor formation in the treated mice, in stark contrast to the control group where half of the mice did develop tumors. Intriguingly, we also noticed that arachidonic acid (another fatty acid) actually promoted tumor growth, suggesting that it might counteract the positive effects of EPA.
Overall, these findings indicate that ultra-high doses of omega-3 fatty acids, particularly DHA and EPA, could offer a promising, low-toxicity treatment for neuroblastoma by blocking tumorigenesis. This research highlights the potential for incorporating dietary fatty acids into cancer therapies, especially for high-risk pediatric patients who currently face limited options.
After the gavage, we introduced neuro-2a cells that were prone to tumor development. Our observations revealed that both DHA and EPA completely halted tumor formation in the treated mice, in stark contrast to the control group where half of the mice did develop tumors. Intriguingly, we also noticed that arachidonic acid (another fatty acid) actually promoted tumor growth, suggesting that it might counteract the positive effects of EPA.
Overall, these findings indicate that ultra-high doses of omega-3 fatty acids, particularly DHA and EPA, could offer a promising, low-toxicity treatment for neuroblastoma by blocking tumorigenesis. This research highlights the potential for incorporating dietary fatty acids into cancer therapies, especially for high-risk pediatric patients who currently face limited options.
Read More
9.5
DHA shows promise against neuroblastoma
Ultra-High Dose Oral ω3 Eicosapentaenoic Acid (EPA), Docosahexaenoic Acid (DHA), or Oxidation-Resistant Deuterated DHA Block Tumorigenesis in a -Driven Neuroblastoma Model.
Strong relevance to DHA's effects
We conducted a study to explore the effects of docosahexaenoic acid (DHA) on tumor formation, particularly in a mouse model of neuroblastoma—a type of aggressive cancer in children. By using a syngeneic model, we gavaged wildtype mice with high doses of omega-3 fatty acids, including DHA, and then injected cancerous cells to monitor tumor development.
In our experiment, we noticed that while 50% of untreated control mice developed tumors, those receiving high doses of DHA or its oxidation-resistant form completely avoided tumor formation. This was quite striking and contrasts with our findings regarding arachidonic acid (ARA), which actually seemed to enhance tumor growth. Notably, when we combined ARA with EPA (another fatty acid), it led to a lower tumor burden, suggesting that DHA acts through a different, non-oxidative mechanism.
These results suggest that high-dose DHA may offer a promising, low-toxicity therapy option for neuroblastoma, paving the way for safer future treatments. It’s exciting to see the potential of omega-3 fatty acids in cancer prevention, especially given their safety and tolerability in humans over extended periods.
In our experiment, we noticed that while 50% of untreated control mice developed tumors, those receiving high doses of DHA or its oxidation-resistant form completely avoided tumor formation. This was quite striking and contrasts with our findings regarding arachidonic acid (ARA), which actually seemed to enhance tumor growth. Notably, when we combined ARA with EPA (another fatty acid), it led to a lower tumor burden, suggesting that DHA acts through a different, non-oxidative mechanism.
These results suggest that high-dose DHA may offer a promising, low-toxicity therapy option for neuroblastoma, paving the way for safer future treatments. It’s exciting to see the potential of omega-3 fatty acids in cancer prevention, especially given their safety and tolerability in humans over extended periods.
Read More
9
Impact of Omega-3 on Cancer
Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression.
Highly relevant cancer treatment insights
We explored the effects of eicosapentaenoic acid, a type of omega-3 fatty acid, on pancreatic cancer using a specially designed mouse model that closely mimics human disease. This model allowed us to examine how adding omega-3 to the diet could impact cancer progression.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.
Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.
Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.
Read More
9
Eicosapentaenoic acid's role explored
Carrageenan-ferrocene-eicosapentaenoic acid composite hydrogel induce ferroptosis and apoptosis for anti-tumor recurrence and metastasis.
Score indicates mixed effectiveness.
We developed a special hydrogel that mixes different components including eicosapentaenoic acid (EPA) to study its effects on cancer treatment. The hydrogel helps target the tumor environment more effectively due to its unique structure.
In our exploration, we noted that this hydrogel encouraged processes like lipid peroxidation and the production of reactive oxygen species, which are known to trigger a type of cell death called ferroptosis. Additionally, it promoted apoptosis, another way cancer cells can die, and supported an immune response in the tumor area.
As we observed, the hydrogel not only worked well in laboratory tests but also showed significant promise in reducing both primary tumors and metastatic growth in live models. This suggests that EPA can play a notable role when combined with innovative treatments, paving the way for better immune responses against tumors.
However, it is essential to highlight that since the study combined EPA with multiple components, isolating its individual impact might be challenging. Thus, while our findings are promising, we must approach the specific benefits of EPA cautiously as part of this comprehensive treatment strategy.
In our exploration, we noted that this hydrogel encouraged processes like lipid peroxidation and the production of reactive oxygen species, which are known to trigger a type of cell death called ferroptosis. Additionally, it promoted apoptosis, another way cancer cells can die, and supported an immune response in the tumor area.
As we observed, the hydrogel not only worked well in laboratory tests but also showed significant promise in reducing both primary tumors and metastatic growth in live models. This suggests that EPA can play a notable role when combined with innovative treatments, paving the way for better immune responses against tumors.
However, it is essential to highlight that since the study combined EPA with multiple components, isolating its individual impact might be challenging. Thus, while our findings are promising, we must approach the specific benefits of EPA cautiously as part of this comprehensive treatment strategy.
Read More
9
EPA's role in cancer treatment
Is Lipid Metabolism of Value in Cancer Research and Treatment? Part II: Role of Specialized Pro-Resolving Mediators in Inflammation, Infections, and Cancer.
Explains eicosapentaenoic acid effects
We focused our research on the potential of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, particularly its derivatives known as specialized pro-resolving mediators (SPMs). These mediators have shown promise in playing a role in the resolution of inflammation, which is crucial in various health conditions, including cancer.
Our observations highlight how SPMs, derived from EPA, exhibit powerful effects in reducing inflammation and can influence cancer cell behavior. Specifically, we noted that these mediators help decrease the proliferation and metastasis of cancer cells, which may lead to slower tumor growth.
Evidence suggests that EPA derivatives, such as Resolvins, not only help in controlling immune cell functions but also aid in clearing out debris in tumor environments. This clearing process can potentially enhance therapeutic outcomes by making the area less conducive to tumor progression.
Altogether, our findings contribute to the idea that EPA has compelling implications for helping manage cancer more effectively, particularly through its ability to modulate the inflammatory response in the body.
Our observations highlight how SPMs, derived from EPA, exhibit powerful effects in reducing inflammation and can influence cancer cell behavior. Specifically, we noted that these mediators help decrease the proliferation and metastasis of cancer cells, which may lead to slower tumor growth.
Evidence suggests that EPA derivatives, such as Resolvins, not only help in controlling immune cell functions but also aid in clearing out debris in tumor environments. This clearing process can potentially enhance therapeutic outcomes by making the area less conducive to tumor progression.
Altogether, our findings contribute to the idea that EPA has compelling implications for helping manage cancer more effectively, particularly through its ability to modulate the inflammatory response in the body.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Essential for family
Due to my family's struggles with cancer, I need to take high doses of fish oil, particularly those rich in EPA. Just one fish oil a day is manageable, especially for the elderly, and it is in an easily absorbed Tg form. I highly recommend it.
9.3
Effective dosage
This high-unit Omega-3 fish oil has no unpleasant smell and is enriched with EPA for its anti-inflammatory and anti-cancer benefits. I find that taking 1-2 capsules daily is very effective, and the DHA aids in preventing dry eyes. It’s a product I continuously repurchase.
8.8
Joint pain reduction
I have been taking Sports Research Fish Oil for a few months and have noticed significant improvements in my heart health and inflammation. Omega-3 reduces inflammation and can lower the risk of chronic diseases like heart disease and cancer. Since starting this supplement, I have experienced reduced joint pain and stiffness, improving my overall well-being. This high-quality, organic fish oil is part of my wellness program, and I highly recommend it for heart health and inflammation reduction.
Read More
7
Anti-inflammatory benefits
Omega-3 is a remarkable nutrient with a wide range of potential health benefits. Found in fatty fish, nuts, and seeds, it has anti-inflammatory properties that may help lower the risk of chronic diseases, including heart disease and cancer. Additionally, omega-3 plays a crucial role in brain health, improving cognitive function, mood, and memory. It may benefit joint, eye, and skin health. Overall, omega-3 can significantly impact health and well-being.
Read More
7.5
Reduces disease risk
Omega-3 fatty acids effectively improve cell insulin sensitivity, reduce inflammation, and decrease cardiovascular disease risk factors in those with metabolic syndrome. They play a role in decreasing chronic inflammation, which can lead to heart disease, cancer, and other serious illnesses.
Read More
