Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.3
USERS' SCORE
Good
Based on 5 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Wild Caught Fish Oil Concentrate
1250 mg
†
Total Omega-3 Fatty Acids as TG
1055 mg
†
EPA (Eicosapentaenoic Acid)
690 mg
†
DHA (Docosahexaenoic Acid)
310 mg
†
Other Omega-3 Fatty Acids
55 mg
†
Top Medical Research Studies
8
We conducted a study to explore the effectiveness of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, in treating major depressive disorder (MDD). Over the course of 12 weeks, 60 participants suffering from MDD were divided into two groups: one received 3.2 grams of EPA daily, while the other group was given a placebo, which was soybean oil.
Throughout the study, we assessed the severity of depression using the Hamilton Rating Scale for Depression (HRSD). What we found was promising. The group taking EPA experienced significantly lower HRSD scores at various checkpoints—specifically at weeks 4, 6, 8, and 12—indicating a reduction in depressive symptoms. Although the rates of remission and response were higher in the EPA group compared to the placebo group, these findings did not achieve statistical significance.
Overall, while EPA shows potential as a treatment for depression, further research is needed to solidify its role. Our findings suggest that it may be an alternative option for MDD patients seeking additional treatment pathways.
Throughout the study, we assessed the severity of depression using the Hamilton Rating Scale for Depression (HRSD). What we found was promising. The group taking EPA experienced significantly lower HRSD scores at various checkpoints—specifically at weeks 4, 6, 8, and 12—indicating a reduction in depressive symptoms. Although the rates of remission and response were higher in the EPA group compared to the placebo group, these findings did not achieve statistical significance.
Overall, while EPA shows potential as a treatment for depression, further research is needed to solidify its role. Our findings suggest that it may be an alternative option for MDD patients seeking additional treatment pathways.
Read More
5
Potential benefits for depression prevention
We conducted a study to explore whether eicosapentaenoic acid (a type of omega-3 fatty acid) can help prevent depression recurrence in older adults who have previously experienced late-life depression. Our research involved a rigorous 52-week double-blind, placebo-controlled trial with 39 patients who were currently stable and free from depression symptoms.
The participants were randomly assigned to either receive daily doses of eicosapentaenoic acid alongside docosahexaenoic acid or a placebo for the duration of the trial. We wanted to see if this supplementation could not only protect against future depressive episodes but also impact depressive and anxiety symptoms, as well as some inflammatory markers associated with depression.
Interestingly, our findings revealed that eicosapentaenoic acid did indeed show a protective effect against the recurrence of depression, with a significant hazard ratio suggesting that those taking the supplement were less likely to relapse compared to the placebo group. However, we didn't observe any notable improvements in current depressive or anxiety symptoms, nor in the inflammatory markers between the two groups.
While the results are promising regarding the prevention of depression recurrence, it's essential to keep in mind the modest size of our sample when interpreting these findings.
The participants were randomly assigned to either receive daily doses of eicosapentaenoic acid alongside docosahexaenoic acid or a placebo for the duration of the trial. We wanted to see if this supplementation could not only protect against future depressive episodes but also impact depressive and anxiety symptoms, as well as some inflammatory markers associated with depression.
Interestingly, our findings revealed that eicosapentaenoic acid did indeed show a protective effect against the recurrence of depression, with a significant hazard ratio suggesting that those taking the supplement were less likely to relapse compared to the placebo group. However, we didn't observe any notable improvements in current depressive or anxiety symptoms, nor in the inflammatory markers between the two groups.
While the results are promising regarding the prevention of depression recurrence, it's essential to keep in mind the modest size of our sample when interpreting these findings.
Read More
9
EPA alleviates depressive behavior
We investigated how eicosapentaenoic acid (EPA) impacts depressive-like behaviors in mice that were subject to chronic sleep deprivation. Our findings indicated that EPA is more effective than docosahexaenoic acid (DHA) in alleviating signs of depression, as evidenced by changes in preferences and behaviors observed in these mice.
Both EPA and DHA were shown to reduce myelin damage and support the health of oligodendrocytes, but EPA led to more significant improvements. We noted higher levels of essential proteins related to myelin repair alongside reduced lipid peroxidation in the presence of EPA.
Notably, both compounds inhibited inflammation pathways associated with depression. However, EPA markedly outperformed DHA in curbing microglial activation and correcting imbalances in immune response. Overall, our research supports the understanding of EPA as a particularly promising option in the fight against depression.
Both EPA and DHA were shown to reduce myelin damage and support the health of oligodendrocytes, but EPA led to more significant improvements. We noted higher levels of essential proteins related to myelin repair alongside reduced lipid peroxidation in the presence of EPA.
Notably, both compounds inhibited inflammation pathways associated with depression. However, EPA markedly outperformed DHA in curbing microglial activation and correcting imbalances in immune response. Overall, our research supports the understanding of EPA as a particularly promising option in the fight against depression.
Read More
Most Useful Reviews
7.5
Supports depression relief
4 people found this helpful
Distinguished Reduces the risk of depression and anxiety, enhancing brain function significantly for concentration and memory. Omega 3 also promotes healthy skin and hair. These pills help reduce appetite during main meals, aiding weight loss likely through regulating serotonin, the hormone that controls appetite. This control can significantly reduce depression symptoms. Quality ingredients and excellent taste.
Read More
7.5
Effective for depression
This Omega 3 has more EPA than DHA, ideal for addressing depression and brain inflammation. It is a superior triglyceride form and allows checking ingredient quality as it is IFOS certified.
Read More
7.5
Reduces depression symptoms
1 people found this helpful
Omega has been a part of my life for years. It maintains blood vessel elasticity, normalises blood pressure, and improves skin condition. It helps with apathy and depression. Though my blood pressure problems persist, they are less frequent now, and I believe Omega helps keep my vessels strong. My skin looks fresher and my hair grows thicker. I prefer this manufacturer for its powerful composition.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.3
- All Researches
9
EPA alleviates depressive behavior
We investigated how eicosapentaenoic acid (EPA) impacts depressive-like behaviors in mice that were subject to chronic sleep deprivation. Our findings indicated that EPA is more effective than docosahexaenoic acid (DHA) in alleviating signs of depression, as evidenced by changes in preferences and behaviors observed in these mice.
Both EPA and DHA were shown to reduce myelin damage and support the health of oligodendrocytes, but EPA led to more significant improvements. We noted higher levels of essential proteins related to myelin repair alongside reduced lipid peroxidation in the presence of EPA.
Notably, both compounds inhibited inflammation pathways associated with depression. However, EPA markedly outperformed DHA in curbing microglial activation and correcting imbalances in immune response. Overall, our research supports the understanding of EPA as a particularly promising option in the fight against depression.
Both EPA and DHA were shown to reduce myelin damage and support the health of oligodendrocytes, but EPA led to more significant improvements. We noted higher levels of essential proteins related to myelin repair alongside reduced lipid peroxidation in the presence of EPA.
Notably, both compounds inhibited inflammation pathways associated with depression. However, EPA markedly outperformed DHA in curbing microglial activation and correcting imbalances in immune response. Overall, our research supports the understanding of EPA as a particularly promising option in the fight against depression.
Read More
9
DPA enhances depression treatment efficacy
We explored the therapeutic benefits of eicosapentaenoic acid (DPA) in treating depression, particularly in relation to exosomes derived from human umbilical cord mesenchymal stem cells. Chronic unpredictable mild stress (CUMS) was used to induce depression-like behaviors in the study, which highlighted the role of neuroinflammation and neurotransmitter deficiencies in this condition.
Through our analysis, we observed that DPA not only improved the effectiveness of exosomes but also significantly alleviated symptoms of depression. The therapy showed a remarkable ability to suppress the harmful activation of specific immune cells in the brain, known as M1 microglia, which are often linked to inflammation. Additionally, DPA helped restore levels of important neurotransmitters, including serotonin and dopamine.
Furthermore, in laboratory tests, the exosomes treated with DPA demonstrated better protective effects against cell death and inflammation-induced damage. Mechanistically, this positive outcome was attributed to DPA’s ability to enhance the expression of a particular microRNA that plays a role in reducing inflammation pathways.
Overall, our findings suggest that DPA treatment combined with exosomes not only addresses neuroinflammation but also promotes overall brain health. This makes it a promising avenue for developing more effective depression treatments.
Through our analysis, we observed that DPA not only improved the effectiveness of exosomes but also significantly alleviated symptoms of depression. The therapy showed a remarkable ability to suppress the harmful activation of specific immune cells in the brain, known as M1 microglia, which are often linked to inflammation. Additionally, DPA helped restore levels of important neurotransmitters, including serotonin and dopamine.
Furthermore, in laboratory tests, the exosomes treated with DPA demonstrated better protective effects against cell death and inflammation-induced damage. Mechanistically, this positive outcome was attributed to DPA’s ability to enhance the expression of a particular microRNA that plays a role in reducing inflammation pathways.
Overall, our findings suggest that DPA treatment combined with exosomes not only addresses neuroinflammation but also promotes overall brain health. This makes it a promising avenue for developing more effective depression treatments.
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9
We utilized a novel approach to study how eicosapentaenoic acid (EPA), part of the omega-3 fatty acids, impacts depression in young mice. By subjecting juvenile mice to different ultrasound frequencies known to induce stress, we effectively created a model that mimics the symptoms of juvenile depression.
Throughout three weeks, we monitored the behavior of these mice, some receiving an EPA and docosahexaenoic acid (DHA) supplement while others did not. We found that the stressed mice given the omega-3 supplement showed no signs of depression or anxiety, which was a stark contrast to the vehicle group that did experience these symptoms.
Additionally, the study indicated that the omega-3 supplementation helped in mitigating the stress responses, such as reduced inflammation in the brain and changes in metabolism. This finding suggests that omega-3 fatty acids could have a therapeutic potential for addressing juvenile depression.
Overall, our observation sheds light on the significant benefits of incorporating eicosapentaenoic acid into diets, especially for young individuals facing mental health challenges.
Throughout three weeks, we monitored the behavior of these mice, some receiving an EPA and docosahexaenoic acid (DHA) supplement while others did not. We found that the stressed mice given the omega-3 supplement showed no signs of depression or anxiety, which was a stark contrast to the vehicle group that did experience these symptoms.
Additionally, the study indicated that the omega-3 supplementation helped in mitigating the stress responses, such as reduced inflammation in the brain and changes in metabolism. This finding suggests that omega-3 fatty acids could have a therapeutic potential for addressing juvenile depression.
Overall, our observation sheds light on the significant benefits of incorporating eicosapentaenoic acid into diets, especially for young individuals facing mental health challenges.
Read More
9
We explored the intriguing relationship between docosahexaenoic acid (DHA), a type of omega-3 polyunsaturated fatty acid, and its potential effects on depression among middle-aged and elderly adults. Our research pulled from a substantial sample size of over 102,000 residents from the UK Biobank, enabling us to thoroughly investigate how varying levels of PUFAs, particularly DHA, are associated with depressive and anxiety disorders.
The findings revealed that higher plasma levels of DHA were linked to a lower risk of developing depressive disorders compared to those with lower levels. Specifically, we observed a hazard ratio of 0.80 for individuals with the highest DHA levels, indicating a significant protective effect. This trend extended to anxiety disorders as well, suggesting that increasing our intake of omega-3 PUFAs might be a reachable goal for enhancing mental health.
Additionally, we noted that higher levels of DHA were also related to a decrease in adverse psychological symptoms. Encompassing the impact on brain health, we incorporated neuroimaging data from nearly 8,800 participants to investigate white matter microstructures, further supporting the link between omega-3 PUFAs like DHA and overall mental well-being.
The evidence we gathered underscores the importance of considering omega-3 PUFAs, particularly DHA, as a promising nutritional approach for helping to prevent and manage depression in older adults.
The findings revealed that higher plasma levels of DHA were linked to a lower risk of developing depressive disorders compared to those with lower levels. Specifically, we observed a hazard ratio of 0.80 for individuals with the highest DHA levels, indicating a significant protective effect. This trend extended to anxiety disorders as well, suggesting that increasing our intake of omega-3 PUFAs might be a reachable goal for enhancing mental health.
Additionally, we noted that higher levels of DHA were also related to a decrease in adverse psychological symptoms. Encompassing the impact on brain health, we incorporated neuroimaging data from nearly 8,800 participants to investigate white matter microstructures, further supporting the link between omega-3 PUFAs like DHA and overall mental well-being.
The evidence we gathered underscores the importance of considering omega-3 PUFAs, particularly DHA, as a promising nutritional approach for helping to prevent and manage depression in older adults.
Read More
9
DHA alleviates epilepsy-related depression
We explored the impact of docosahexaenoic acid (DHA) on depressive symptoms associated with epilepsy in a young mouse model. Through our investigation, we fed mice a diet enriched with DHA and administered pentylenetetrazole (PTZ) to induce epilepsy. Notably, our findings indicated that both DHA and eicosapentaenoic acid (EPA) significantly reduced depressive symptoms in this model, with EPA showing even greater effectiveness.
Analyzing the underlying mechanisms revealed that DHA and EPA helped repair neuronal damage and improve myelin structure in the hippocampus—the brain region vital for mood regulation. Furthermore, they tackled neuroinflammation by encouraging the polarizing of microglial cells toward a protective state and suppressing harmful inflammatory responses.
Additionally, we observed that both fatty acids decreased oxidative stress and improved mitochondrial function, which are crucial aspects of brain health. These results suggest that integrating DHA (and EPA) into dietary interventions could offer a promising strategy to alleviate depression in children with epilepsy, providing a potential pathway to enhance their quality of life.
Analyzing the underlying mechanisms revealed that DHA and EPA helped repair neuronal damage and improve myelin structure in the hippocampus—the brain region vital for mood regulation. Furthermore, they tackled neuroinflammation by encouraging the polarizing of microglial cells toward a protective state and suppressing harmful inflammatory responses.
Additionally, we observed that both fatty acids decreased oxidative stress and improved mitochondrial function, which are crucial aspects of brain health. These results suggest that integrating DHA (and EPA) into dietary interventions could offer a promising strategy to alleviate depression in children with epilepsy, providing a potential pathway to enhance their quality of life.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Supports depression relief
4 people found this helpful
Distinguished Reduces the risk of depression and anxiety, enhancing brain function significantly for concentration and memory. Omega 3 also promotes healthy skin and hair. These pills help reduce appetite during main meals, aiding weight loss likely through regulating serotonin, the hormone that controls appetite. This control can significantly reduce depression symptoms. Quality ingredients and excellent taste.
Read More
7.5
Effective for depression
This Omega 3 has more EPA than DHA, ideal for addressing depression and brain inflammation. It is a superior triglyceride form and allows checking ingredient quality as it is IFOS certified.
Read More
7.5
Reduces depression symptoms
1 people found this helpful
Omega has been a part of my life for years. It maintains blood vessel elasticity, normalises blood pressure, and improves skin condition. It helps with apathy and depression. Though my blood pressure problems persist, they are less frequent now, and I believe Omega helps keep my vessels strong. My skin looks fresher and my hair grows thicker. I prefer this manufacturer for its powerful composition.
Read More
7.5
Alleviates depression symptoms
1 people found this helpful
High-concentration, high-quality fish oil significantly reduces symptoms of depression caused by late nights.
Read More
7.5
Essential for depression
I have taken this Omega 3 for a long time and return to it when out of stock. I appreciate the EPA and DHA combination, essential for depression, and my whole family uses this product.
Read More
Frequently Asked Questions
7.5
Supports depression relief
4 people found this helpful
Distinguished Reduces the risk of depression and anxiety, enhancing brain function significantly for concentration and memory. Omega 3 also promotes healthy skin and hair. These pills help reduce appetite during main meals, aiding weight loss likely through regulating serotonin, the hormone that controls appetite. This control can significantly reduce depression symptoms. Quality ingredients and excellent taste.
7.5
Reduces depression symptoms
1 people found this helpful
Omega has been a part of my life for years. It maintains blood vessel elasticity, normalises blood pressure, and improves skin condition. It helps with apathy and depression. Though my blood pressure problems persist, they are less frequent now, and I believe Omega helps keep my vessels strong. My skin looks fresher and my hair grows thicker. I prefer this manufacturer for its powerful composition.
7.5
Effective for depression
This Omega 3 has more EPA than DHA, ideal for addressing depression and brain inflammation. It is a superior triglyceride form and allows checking ingredient quality as it is IFOS certified.
7.5
Alleviates depression symptoms
1 people found this helpful
High-concentration, high-quality fish oil significantly reduces symptoms of depression caused by late nights.
4
We examined the effectiveness of eicosapentaenoic acid (EPA), a type of omega-3 polyunsaturated fatty acid, in treating depression. After analyzing 36 well-structured studies, we found some positive outcomes and also observed notable variability in the results. The overall findings suggested that EPA could offer benefits for depression, yielding a small but statistically significant improvement in symptoms.
It's particularly interesting to note that for Asian patients experiencing mild to moderate depression, the best results seemed to emerge with a daily dosage of 1000 to 1500 mg of omega-3s over eight weeks. This intake should ideally have a specific balance of EPA to another omega-3, docosahexaenoic acid (DHA), set at between 1:1 and 2:1 ratios. However, despite these encouraging indications, our analysis also revealed that EPA isn’t better than a placebo for achieving response or remission rates or for adverse events.
Overall, while omega-3 PUFAs like EPA may hold promise for managing depressive symptoms, we must approach the findings with caution. Further research is warranted to deepen our understanding of how to harness the potential benefits of these fatty acids in treating depression.
It's particularly interesting to note that for Asian patients experiencing mild to moderate depression, the best results seemed to emerge with a daily dosage of 1000 to 1500 mg of omega-3s over eight weeks. This intake should ideally have a specific balance of EPA to another omega-3, docosahexaenoic acid (DHA), set at between 1:1 and 2:1 ratios. However, despite these encouraging indications, our analysis also revealed that EPA isn’t better than a placebo for achieving response or remission rates or for adverse events.
Overall, while omega-3 PUFAs like EPA may hold promise for managing depressive symptoms, we must approach the findings with caution. Further research is warranted to deepen our understanding of how to harness the potential benefits of these fatty acids in treating depression.
8
We focused on the effectiveness of eicosapentaenoic acid (EPA) as a treatment for mild depression. Comprehensive searches led us to several randomized controlled trials that examined how EPA could help those experiencing symptoms of mild depression.
Our analysis highlighted that EPA, found in certain fish oils, shows potential as a therapeutic option for individuals with mild depression. While some studies presented promising findings, we noted that rigorous research explicitly comparing EPA against placebo was limited.
Moreover, our review found that supplements like EPA may contribute positively to symptom relief. However, due to the lack of direct comparisons with antidepressants or detailed isolation of EPA's effects, we do not claim conclusive superiority over existing treatments at this time.
Overall, while there is hope regarding EPA's role in assisting with mild depression, we must call for further studies and more comprehensive research to validate these benefits fully.
Our analysis highlighted that EPA, found in certain fish oils, shows potential as a therapeutic option for individuals with mild depression. While some studies presented promising findings, we noted that rigorous research explicitly comparing EPA against placebo was limited.
Moreover, our review found that supplements like EPA may contribute positively to symptom relief. However, due to the lack of direct comparisons with antidepressants or detailed isolation of EPA's effects, we do not claim conclusive superiority over existing treatments at this time.
Overall, while there is hope regarding EPA's role in assisting with mild depression, we must call for further studies and more comprehensive research to validate these benefits fully.
8
We examined the therapeutic effects of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, in treating major depressive disorder (MDD). A variety of studies from reputable databases highlighted the promising potential of higher doses of EPA, particularly for individuals with specific conditions like elevated inflammation markers, cardiovascular comorbidities, or those in younger age brackets such as children and adolescents.
Participants who received doses greater than 1 gram per day of EPA showed notable improvements in their depressive symptoms. We also observed that these improvements were linked to increases in beneficial lipid mediators that help reduce inflammation. This suggests that EPA could work as an adjunct treatment, enhancing mood, cognitive functions, and even metabolic health.
Although we see encouraging results, particularly for those with certain types of depression, we acknowledge that more robust research is necessary. Further investigations will help us refine dosing strategies, treatment durations, and identify which patient groups can benefit the most from this therapy. Looking ahead, it will be vital to explore long-term effects and interactions with other treatments as well.
Participants who received doses greater than 1 gram per day of EPA showed notable improvements in their depressive symptoms. We also observed that these improvements were linked to increases in beneficial lipid mediators that help reduce inflammation. This suggests that EPA could work as an adjunct treatment, enhancing mood, cognitive functions, and even metabolic health.
Although we see encouraging results, particularly for those with certain types of depression, we acknowledge that more robust research is necessary. Further investigations will help us refine dosing strategies, treatment durations, and identify which patient groups can benefit the most from this therapy. Looking ahead, it will be vital to explore long-term effects and interactions with other treatments as well.
4
We explored the impacts of eicosapentaenoic acid (EPA), an omega-3 fatty acid, on depression through recent research. The evidence suggests that EPA and another omega-3, docosahexaenoic acid (DHA), may have positive effects on mood by influencing brain processes such as inflammation, neurotransmitter function, and neural connectivity.
However, we observed mixed results from clinical trials on the effectiveness of EPA supplements. While some studies report significant improvements in depressive symptoms following EPA treatment, others find minimal or no benefits. Factors like different dosages, the balance of EPA and DHA used, and individuals' nutritional backgrounds seem to affect these outcomes.
Although promising, it seems that EPA might work best as an additional treatment alongside traditional antidepressants rather than as a standalone solution. As we continue to see variations in study designs and responses among individuals, more research is essential to solidify consistent guidelines for using EPA in managing depression.
However, we observed mixed results from clinical trials on the effectiveness of EPA supplements. While some studies report significant improvements in depressive symptoms following EPA treatment, others find minimal or no benefits. Factors like different dosages, the balance of EPA and DHA used, and individuals' nutritional backgrounds seem to affect these outcomes.
Although promising, it seems that EPA might work best as an additional treatment alongside traditional antidepressants rather than as a standalone solution. As we continue to see variations in study designs and responses among individuals, more research is essential to solidify consistent guidelines for using EPA in managing depression.
References
- Kong L, Zhang Q, Wang H, Xu Y, Xu C, et al. Exploration of the optimized portrait of omega-3 polyunsaturated fatty acids in treating depression: A meta-analysis of randomized-controlled trials. J Affect Disord. 2025. doi:10.1016/j.jad.2025.03.006
- Urata M, Sakurai H, Ueno F, Maruki T, Tada T, et al. Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis. Neuropsychopharmacol Rep. 2025;45:e70008. doi:10.1002/npr2.70008
- Dyall SC, Malau IA, Su KP. Omega-3 polyunsaturated fatty acids in depression: insights from recent clinical trials. Curr Opin Clin Nutr Metab Care. 2025;28:66. doi:10.1097/MCO.0000000000001077
- Faulkner P, Gibson EL, Dyall SC. Long-chain omega-3 polyunsaturated fatty acids are associated with brain connectivity and mood in young adults with subthreshold depression: A preliminary study. Prostaglandins Leukot Essent Fatty Acids. 2025;204:102664. doi:10.1016/j.plefa.2025.102664
- Campisi SC, Zasowski C, Bradley-Ridout G, Schumacher A, Szatmari P, et al. Omega-3 fatty acid supplementation for depression in children and adolescents. Cochrane Database Syst Rev. 2024;11:CD014803. doi:10.1002/14651858.CD014803.pub2
- Wu SK, Yang KJ, Liu WC, Malau IA, Zailani H, et al. The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Nutrients. 2024;16. doi:10.3390/nu16213688
- Lin YW, Cheng SW, Liu WC, Zailani H, Wu SK, et al. Chemogenetic targeting TRPV1 in obesity-induced depression: Unveiling therapeutic potential of eicosapentaenoic acid and acupuncture. Brain Behav Immun. 2025;123:771. doi:10.1016/j.bbi.2024.10.028
- Chen L, Yang Y, Zhang N, Che H, Wang Z, et al. DHA and EPA alleviate depressive-like behaviors in chronic sleep-deprived mice: Involvement of iron metabolism, oligodendrocyte-lipids peroxidation and the LCN2-NLRP3 signaling axis. Free Radic Biol Med. 2024;225:654. doi:10.1016/j.freeradbiomed.2024.10.298
- Li P, Zhang F, Huang C, Zhang C, Yang Z, et al. Exosomes Derived from DPA-treated UCMSCs Attenuated Depression-like Behaviors and Neuroinflammation in a Model of Depression Induced by Chronic Stress. J Neuroimmune Pharmacol. 2024;19:55. doi:10.1007/s11481-024-10154-6
- Cheng YC, Chen WY, Lin C, Lee SH, Chiu CC, et al. The N-3 polyunsaturated fatty acids supplementation to prevent depression recurrence in patients with late-life depression: A 52-week double-blind, placebo-controlled trial. J Affect Disord. 2025;369:8. doi:10.1016/j.jad.2024.09.129
- Serefko A, Jach ME, Pietraszuk M, Świąder M, Świąder K, et al. Omega-3 Polyunsaturated Fatty Acids in Depression. Int J Mol Sci. 2024;25. doi:10.3390/ijms25168675
- Lin YL, Wang CL, Chiang TI. Eicosapentaenoic acid supplementation alleviates pruritus, enhances skin moisture, and mitigates depression in maintenance hemodialysis patients. Front Nephrol. 2024;4:1365809. doi:10.3389/fneph.2024.1365809
- Strekalova T, Radford-Smith D, Dunstan IK, Gorlova A, Svirin E, et al. Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression. Neurobiol Stress. 2024;31:100646. doi:10.1016/j.ynstr.2024.100646
- Carnegie R, Borges MC, Jones HJ, Zheng J, Haycock P, et al. Omega-3 fatty acids and major depression: a Mendelian randomization study. Transl Psychiatry. 2024;14:222. doi:10.1038/s41398-024-02932-w
- Lou F, Luo S, Kang N, Yan L, Long H, et al. Oral microbiota dysbiosis alters chronic restraint stress-induced depression-like behaviors by modulating host metabolism. Pharmacol Res. 2024;204:107214. doi:10.1016/j.phrs.2024.107214
- Zhang C, Hou B, Xu Y, Zeng S, Luo X, et al. Association between eicosapentaenoic acid consumption and the risk of depressive symptoms in US adults: Analyses from NHANES 2005-2018. J Affect Disord. 2024;354:62. doi:10.1016/j.jad.2024.03.055
- Huang S, Guo J, Jiang R, Ma K, Lin F, et al. Four-way decomposition of the effects of nutrient supplement and physical exercise on depression among older Chinese: a nationwide cross-sectional analysis. BMC Public Health. 2024;24:3469. doi:10.1186/s12889-024-20995-8
- Li Y, Hua L, Ran Q, Gu J, Bao Y, et al. Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults. Nutrients. 2024;16. doi:10.3390/nu16234065
- Wang M, Yan X, Li Y, Li Q, Xu Y, et al. Association between plasma polyunsaturated fatty acids and depressive among US adults. Front Nutr. 2024;11:1342304. doi:10.3389/fnut.2024.1342304
- Chang YY, Ting B, Chen DT, Hsu WT, Lin SC, et al. Omega-3 Fatty Acids for Depression in the Elderly and Patients with Dementia: A Systematic Review and Meta-Analysis. Healthcare (Basel). 2024;12. doi:10.3390/healthcare12050536
- Suneson K, Söderberg Veibäck G, Lindahl J, Tjernberg J, Ståhl D, et al. Omega-3 fatty acids for inflamed depression - A match/mismatch study. Brain Behav Immun. 2024;118:192. doi:10.1016/j.bbi.2024.02.029
- Xue Y, Wang L, Liu T, Zhao T, Xie K, et al. Omega-3 polyunsaturated fatty acids supplementation improves memory in first-diagnosed, drug-naïve patients with depression: Secondary analysis of data from a randomized controlled trial. J Affect Disord. 2024;350:403. doi:10.1016/j.jad.2024.01.149
- Yang Y, Chen L, Zhang N, Zhao Y, Che H, et al. DHA and EPA Alleviate Epileptic Depression in PTZ-Treated Young Mice Model by Inhibiting Neuroinflammation through Regulating Microglial M2 Polarization and Improving Mitochondrial Metabolism. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12122079
