Overview
Top Medical Research Studies
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
Most Useful Reviews
Medical Researches
- All Researches
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
Following treatment, her blood tests showed consistent improvement, indicating that oral B12 replacement can be an effective management strategy, especially for patients who can’t tolerate injections. This case underscores the importance of genetic testing for accurate diagnoses.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
User Reviews
- All Reviews
- Positive Reviews
- Negative Reviews
Frequently Asked Questions
Anemia is a medical condition characterized by a deficiency of red blood cells or hemoglobin in the blood, which can result in reduced oxygen flow to the body's organs. The most common type of anemia is iron-deficiency anemia, which occurs when the body does not have enough iron to produce adequate hemoglobin. Other types can arise from chronic diseases, genetic conditions, or a lack of certain vitamins such as B12 or folate. Symptoms often include fatigue, weakness, pale skin, and shortness of breath, particularly during physical activity.
Diagnosing anemia typically involves blood tests to measure levels of red blood cells, hemoglobin concentration, and other related factors. Treatment varies depending on the underlying cause but may include dietary changes, supplements, or medications. In some cases, more serious interventions may be necessary, such as blood transfusions or treatments for associated conditions. If you suspect you have anemia, it's essential to consult a healthcare professional for appropriate evaluation and management.
Vitamin B12, also known as cobalamin, is a water-soluble vitamin that plays a crucial role in several vital functions in the human body. It is essential for red blood cell formation, neurological function, and DNA synthesis. Naturally occurring in animal products, the vitamin can be found in high concentrations in meat, fish, eggs, and dairy, making it particularly important for those following a vegetarian or vegan diet, as plant-based sources of B12 are limited and often require supplementation.
A deficiency in vitamin B12 can lead to serious health issues, including anemia, fatigue, memory problems, and nerve damage. Due to its significance, it's crucial for individuals, particularly those at risk of deficiency, to ensure adequate intake through diet or supplementation. For most adults, the recommended daily allowance (RDA) is around 2.4 micrograms, though pregnant or breastfeeding women may require higher amounts. If you're considering B12 supplements, it's advisable to consult with a healthcare provider to determine the best option for your specific needs and health status.
B12 plays a crucial role in the formation of red blood cells, and a deficiency can lead to a specific type of anemia called pernicious anemia. In this condition, the body lacks sufficient vitamin B12, which is essential for producing healthy red blood cells, resulting in a decreased ability to transport oxygen throughout the body. Symptoms of this type of anemia can include fatigue, weakness, and even neurological issues if left untreated.
Supplementing with B12 can alleviate these symptoms and correct the deficiency, making it an effective part of the treatment plan for those diagnosed with pernicious anemia. However, it's essential to consult with a healthcare professional before starting supplementation, as the specific needs can vary significantly between individuals. They may recommend dietary adjustments or injections depending on the severity of the deficiency and the underlying causes. In sum, while B12 can certainly help with certain types of anemia, addressing the root cause with professional guidance is key for effective treatment.
Based on user reviews, many individuals report experiencing improvements in their condition relatively quickly after starting vitamin B12 supplements for anemia. For instance, one user mentioned seeing their hemoglobin and ferritin levels rise immediately after taking the supplement, which they specifically sought for a deficiency they had struggled with for a long time (Read Review). Another user who experienced anemia following stomach cancer surgery noted swift improvements, particularly related to their overall well-being and ability to enjoy food again (Read Review).
Overall, while individual results may vary, users generally suggest that noticeable changes can occur soon after beginning supplementation, underscoring the effectiveness of B12 in addressing deficiencies and aiding recovery from anemia. However, it's essential to consult a healthcare provider about the appropriate dosage and duration of use tailored to individual needs.
Research consistently supports the use of vitamin B12 as an effective treatment for various forms of anemia, particularly pernicious anemia, characterized by vitamin B12 deficiency. For instance, a case review involved a 40-year-old woman whose neurological improvements were linked to parenteral B12 treatment after misdiagnosis [1]. Furthermore, a significant majority (over 80%) of patients diagnosed with pernicious anemia in a study demonstrated sustained health benefits from ongoing vitamin B12 therapy, confirming its critical role in managing this type of anemia [7].
Moreover, various studies highlight how vitamin B12 supplementation, whether through oral or parenteral methods, leads to substantial improvements in hemoglobin levels and alleviates anemia symptoms across diverse patient demographics. In children, for example, vitamin B12 treatments successfully addressed anemia caused by dietary deficiencies, showcasing its importance in pediatric health [12]. Overall, the cumulative evidence from these case studies solidifies vitamin B12 as a scientifically-backed supplement for effectively treating anemia.
Users report a range of improvements in their symptoms after incorporating vitamin B12 supplements into their routines. Many individuals, like one user who faced peeling at the corners of their lips—a sign of B12 deficiency—observed a rapid restoration of health upon taking the supplement (Read Review). Another user noted immediate increases in hemoglobin and ferritin levels after discovering their deficiency, reflecting a direct impact on anemia symptoms (Read Review). Furthermore, users have reported enhanced energy levels and improvements in cognitive functions, including reduced anxiety and forgetfulness, which have significantly improved their overall well-being and functionality in daily life (Read Review).
Additionally, several reviews highlight the swift alleviation of symptoms following medical procedures, such as one user who experienced rapid recovery from mouth inflammation resulting from a B12 deficiency post-surgery, enhancing their ability to enjoy food once again (Read Review). While these anecdotal experiences illustrate the potential benefits of B12 supplementation, individual results may vary, emphasizing the importance of personalized consultation with a healthcare professional.
Users report a positive experience when combining vitamin B12 supplements with other supplements for managing anemia. Several individuals shared that their specific deficiencies, such as B12 and folic acid, were effectively addressed, leading to noticeable improvements in their hemoglobin and ferritin levels. For example, one user mentioned that after realizing their anemia was due to both B12 and folic acid deficiency, they found this supplement worked wonders, leading to immediate results in their blood levels (Read Review). Another user indicated that they were able to maintain adequate B12 levels as part of their overall strategy to combat anemia, suggesting that a comprehensive approach can be beneficial (Read Review).
Moreover, some reviews suggest that the combination of B12 with other vitamin supplementation might enhance its effectiveness. One user noted significant benefits after recognizing that multiple deficiencies contributed to their anemia, thereby highlighting the importance of addressing various nutrient needs simultaneously (Read Review). Ultimately, while many users have found success through an integrated supplementation approach, they emphasize the importance of personalized consultation with healthcare providers to determine the best course of action.
When it comes to treating anemia related to vitamin B12 deficiency, research suggests that the optimal dosing can vary depending on individual circumstances and the specific type of anemia being addressed. For instance, a case study demonstrated that parenteral (injection) supplementation of high doses of methylcobalamin significantly improved symptoms of pernicious anemia in a patient, indicating the efficacy of injectable forms in acute presentations (see research-id='39966940'). Moreover, for those with pernicious anemia, a daily oral dosage of 1000 μg has been shown to effectively rectify deficiencies within a month, further supporting the use of both injectable and oral B12 in treatment approaches (see research-id='38797248').
Additionally, specialized formulations like Sucrosomial vitamin B12 have demonstrated improved bioavailability, with studies indicating that they can outperform conventional supplements in elevating serum B12 levels (see research-id='39582666'). This is particularly important for individuals who may have absorption challenges. Ultimately, while there’s evidence suggesting that doses of up to 200 μg are generally safe for daily use and higher doses may be necessary for severe or specific deficiencies, it’s crucial for treatment plans to be tailored to the individual under medical guidance (see research-id='39939550'). This ensures the best outcomes and regular monitoring of hemoglobin and vitamin B12 levels throughout treatment.
After starting parenteral B12 treatment, we observed significant neurological improvements, underscoring how vital it is to recognize vitamin B12 deficiency as a potential cause of anemia, even when classic symptoms aren't present. This case reminds us to maintain a broad perspective for accurate diagnosis.
During the follow-up period, those receiving consistent B12 therapy showed no relapse, while interruptions led to a significant relapse rate. Our findings suggest that screening for PA is crucial and highlight the importance of ongoing B12 supplementation for affected patients.
After a thorough assessment and personalized nutritional support, including supplements, his condition improved over several months. This case highlights the importance of addressing dietary restrictions in children with ASD to prevent deficiencies like anemia.
References
- Mesgarankarimi A, Rezapour M, Tabrizi N. A long-standing undiagnosed case of vitamin B12 deficiency: a case report. J Med Case Rep. 2025;19:151. doi:10.1186/s13256-025-05149-7
- Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. doi:10.1016/S2214-109X(24)00559-X
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
- Hirakata K, Ishii Y, Yoshida T, Tanaka F, Nakae Y. [A case of diagnosed pernicious anemia and subacute combined degeneration of the spinal cord with abnormally elevated serum vitamin B12]. Rinsho Shinkeigaku. 2025;65:120. doi:10.5692/clinicalneurol.cn-002023
- Zhang D, Liu S, Xi B, Zhu Y, Chen Y, et al. Imerslund-Gräsbeck syndrome in a child with a novel compound heterozygous mutations in the AMN gene: a case report. Ital J Pediatr. 2024;50:191. doi:10.1186/s13052-024-01757-z
- Di Sario F, Piloni F, Gasparini F, Serpetti E, Bruschi B, et al. Severe pancytopenia at the presentation of Imerslund-Gräsbeck syndrome in a 23-month-old Italian boy. Ital J Pediatr. 2024;50:186. doi:10.1186/s13052-024-01759-x
- Shen M, Luo X, Wu C, Wang J, Wang Z, et al. Pernicious anemia is a common cause of cobalamin deficiency-caused megaloblastic anemia in Hainan, China. Hematology. 2024;29:2399375. doi:10.1080/16078454.2024.2399375
- Iqbal N, Meghani MA, Khalid W, Ansari AH, Ansari MUH, et al. Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report. Ann Hematol. 2024;103:3243. doi:10.1007/s00277-024-05878-7
- Song JH, Park SH, Cho M, Kim YM, Hyung WJ, et al. Proximal Gastrectomy Is Associated with Lower Incidence of Anemia and Vitamin B12 Deficiency Compared to Total Gastrectomy in Patients with Upper Gastric Cancer. Cancer Res Treat. 2025;57:174. doi:10.4143/crt.2024.319
- Lacombe V, Vinatier E, Roquin G, Copin MC, Delattre E, et al. Oral vitamin B12 supplementation in pernicious anemia: a prospective cohort study. Am J Clin Nutr. 2024;120:217. doi:10.1016/j.ajcnut.2024.05.019
- Chakrabarti S, Ajjampur SSR, Waddington HS, Kishore A, Nguyen PH, et al. Deworming and micronutrient status by community open defecation prevalence: An observational study using nationally representative data from India, 2016-2018. PLoS Med. 2024;21:e1004402. doi:10.1371/journal.pmed.1004402
- Sawada Y, Sakamoto K, Tsukamura A, Sawai C. Vitamin B12 deficiency-induced megaloblastic anemia in a pediatric patient with autism spectrum disorder with a chronically unbalanced diet. Int J Hematol. 2024;119:613. doi:10.1007/s12185-024-03759-3
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
- Sachdeva M, Purohit A, Malik M, Jain L, Pradhan P, et al. Comparison of Efficacy and Safety of Parenteral vs Oral Route of Vitamin B12 Supplementation for the Treatment of Vitamin B12 Deficiency Anemia in Children: A Systematic Review. Nutr Rev. 2025. doi:10.1093/nutrit/nuae227
- Obeid R, Geisel J, Pietrzik K, Andres E. A Framework to Guide Defining an Upper Threshold of Crystalline Vitamin B12 in Foods and Food Supplements. Curr Nutr Rep. 2025;14:32. doi:10.1007/s13668-025-00622-7
- Hirakata K, Ishii Y, Yoshida T, Tanaka F, Nakae Y. [A case of diagnosed pernicious anemia and subacute combined degeneration of the spinal cord with abnormally elevated serum vitamin B12]. Rinsho Shinkeigaku. 2025;65:120. doi:10.5692/clinicalneurol.cn-002023
- Belhaj R, Maaloul I, Kolsi R, Rekik T, Chabchoub I, et al. Study of clinical manifestations and etiologies of megaloblastic anemia in children. Transfus Clin Biol. 2025. doi:10.1016/j.tracli.2025.01.006
- Goncalves H, De Oliveira Simões F, Sá R, Fraga Campos B, Domingues RM, et al. Severe Symptomatic Anemia as a Rare Initial Manifestation of Type 3 Polyglandular Autoimmune Syndrome: A Case Report. Cureus. 2024;16:e75800. doi:10.7759/cureus.75800
- Moreira AP, Vasconcelos M, Costa E Silva T, Relvas C, Espírito Santo J. An Unusual Case of Hemolytic Anemia: A Case Report. Cureus. 2024;16:e75676. doi:10.7759/cureus.75676
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. doi:10.1186/s12887-024-05262-4
- Tavares Pereira J, Barbosa Barroso J, Azevedo A, Ribeiro A, Tonel C. Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency. Cureus. 2024;16:e73620. doi:10.7759/cureus.73620
- Jamil M, Nasser Z, Jamil D, Sheqwara JZ. Unmasking Vitamin B12 Deficiency Misdiagnosed as Myelodysplastic Syndrome. Case Rep Hematol. 2024;2024:3258227. doi:10.1155/2024/3258227
- Memon NM, Conti G, Brilli E, Tarantino G, Chaudhry MNA, et al. Comparative bioavailability study of supplemental oral Sucrosomial vs. oral conventional vitamin B12 in enhancing circulatory B12 levels in healthy deficient adults: a multicentre, double-blind randomized clinical trial. Front Nutr. 2024;11:1493593. doi:10.3389/fnut.2024.1493593
