Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.4
USERS' SCORE
Good
Based on 22 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
9
We explored the intriguing link between vitamin B12 deficiency and anemia, particularly through a rare condition known as pseudo-thrombotic microangiopathy. This condition mimics other thrombotic microangiopathies and could lead to unnecessary treatments such as plasmapheresis.
Our findings suggest that this situation should be taken seriously in patients showing signs of microangiopathic hemolytic anemia. It's essential to promptly administer vitamin B12 supplements in these cases, as it can effectively address the root cause of the anemia.
While the lab results may initially appear similar to conditions like thrombotic thrombocytopenic purpura, we noted important differences, particularly in the reticulocyte production index, which can help differentiate between these conditions. Overall, it emphasizes the importance of recognizing how vitamin B12 treatment can alleviate symptoms related to its deficiency.
Our findings suggest that this situation should be taken seriously in patients showing signs of microangiopathic hemolytic anemia. It's essential to promptly administer vitamin B12 supplements in these cases, as it can effectively address the root cause of the anemia.
While the lab results may initially appear similar to conditions like thrombotic thrombocytopenic purpura, we noted important differences, particularly in the reticulocyte production index, which can help differentiate between these conditions. Overall, it emphasizes the importance of recognizing how vitamin B12 treatment can alleviate symptoms related to its deficiency.
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7
We sought to understand how effective vitamin B12 is in treating anemia in children. Our focus was on comparing two different methods of supplementation: parenteral (injections) and oral (pills). While previous studies in adults suggested both methods might have similar benefits, we found limited data for children, prompting our thorough investigation.
Our literature search pulled from multiple reputable databases for randomized controlled trials that specifically looked at vitamin B12 treatments in children with deficiency anemia. Of the thousands of studies reviewed, only one qualified for our analysis. In this study, children received an initial injection of vitamin B12 before being assigned to either the parenteral or oral treatment group.
We observed notable differences in the outcomes after three months. The children who received the parenteral treatment showed significantly higher vitamin B12 levels and better improvements in hemoglobin, indicating that this method may be more effective. However, we should note that the quality of the study was deemed high risk for bias, and there was no safety data reported, making it challenging to draw strong conclusions.
Overall, while the findings hint at a greater effectiveness of parenteral supplementation, the lack of robust evidence calls for caution in interpreting these results. Further high-quality research is necessary before definitive recommendations can be made.
Our literature search pulled from multiple reputable databases for randomized controlled trials that specifically looked at vitamin B12 treatments in children with deficiency anemia. Of the thousands of studies reviewed, only one qualified for our analysis. In this study, children received an initial injection of vitamin B12 before being assigned to either the parenteral or oral treatment group.
We observed notable differences in the outcomes after three months. The children who received the parenteral treatment showed significantly higher vitamin B12 levels and better improvements in hemoglobin, indicating that this method may be more effective. However, we should note that the quality of the study was deemed high risk for bias, and there was no safety data reported, making it challenging to draw strong conclusions.
Overall, while the findings hint at a greater effectiveness of parenteral supplementation, the lack of robust evidence calls for caution in interpreting these results. Further high-quality research is necessary before definitive recommendations can be made.
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9
We explored the intriguing case of a 51-year-old man in Western Uganda who experienced lower limb weakness linked to pernicious anemia, a condition caused by vitamin B12 deficiency. His journey illustrates the importance of recognizing the signs of this often-overlooked autoimmune disease.
Initially presenting with macrocytic anemia, our patient had a history of similar symptoms seven years prior, which were treated for vitamin B12 deficiency. This time, additional tests confirmed that pernicious anemia was at play, allowing for targeted treatment.
After starting parenteral methylcobalamin therapy, he showed significant improvement in his symptoms. This case underscores that vitamin B12 is crucial not just for red blood cell production but also for neurological health, emphasizing the need for increased awareness and diagnosis of vitamin B12 deficiencies in resource-limited settings.
Initially presenting with macrocytic anemia, our patient had a history of similar symptoms seven years prior, which were treated for vitamin B12 deficiency. This time, additional tests confirmed that pernicious anemia was at play, allowing for targeted treatment.
After starting parenteral methylcobalamin therapy, he showed significant improvement in his symptoms. This case underscores that vitamin B12 is crucial not just for red blood cell production but also for neurological health, emphasizing the need for increased awareness and diagnosis of vitamin B12 deficiencies in resource-limited settings.
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Most Useful Reviews
9
Reduced anemia symptoms
10 people found this helpful
Folic acid is touted as beneficial for pregnant women, and I found it cheaper to buy here. Having suffered from iron deficiency for decades, taking this alongside iron finally eliminated my anemia. I wish I had discovered it sooner; its effects are remarkable for both physical and mental health!
Read More
10
Stable hemoglobin
1 people found this helpful
I would buy again. After taking it, my haemoglobin levels are stable and there's no sign of anaemia, thanks to B12.
Read More
9
Effective results
1 people found this helpful
Prescribed by my sister's gynaecologist for conception, I know that folic acid addresses a deficiency in the body and is vital for overcoming anemia. I’m pleased with the packaging and the noticeable results.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.4
- All Researches
9.5
We assessed how nutrition education, combined with iron-folic acid supplementation, impacts hemoglobin levels and adherence to supplementation among pregnant women in Ethiopia. Over three months, pregnant women received community-based education and were given supplements for six weeks.
The results were promising! After the intervention, anemia rates fell significantly from 27.8% to 7.2% among those who received education. Moreover, those participants showed much higher adherence to the supplementation compared to those who did not, suggesting that combining education with iron-folic acid intake can effectively improve health outcomes for pregnant women.
The results were promising! After the intervention, anemia rates fell significantly from 27.8% to 7.2% among those who received education. Moreover, those participants showed much higher adherence to the supplementation compared to those who did not, suggesting that combining education with iron-folic acid intake can effectively improve health outcomes for pregnant women.
Read More
9.5
Family education improves anemia treatment
We investigated how family-centered health education influences adherence to iron-folic acid supplements and improves anemia among pregnant women. Through a quasi-experimental trial, we compared results from intervention and control groups, focusing on women aged 14-16 weeks with anemia.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
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9.5
Our exploration centered on how folate impacts anemia, specifically in cases of vitamin B12 deficiency. We observed that while vitamin B12 is often the star player in reversing anemia symptoms, folate also plays a critical support role.
Despite this, the data from related cases indicated that isolated folate treatment did not provide significant benefits in correcting anemia. The connection between folate and hemolytic anemia became clear, yet treatment focused primarily on reintroducing vitamin B12, suggesting that folate’s contribution might not be as decisive on its own.
This finding emphasizes the importance of comprehensive treatment approaches and the need for health care providers to consider both vitamins in managing anemia. Ultimately, the positive outcomes we identified were closely tied to vitamin B12 administration rather than folate acting independently.
Despite this, the data from related cases indicated that isolated folate treatment did not provide significant benefits in correcting anemia. The connection between folate and hemolytic anemia became clear, yet treatment focused primarily on reintroducing vitamin B12, suggesting that folate’s contribution might not be as decisive on its own.
This finding emphasizes the importance of comprehensive treatment approaches and the need for health care providers to consider both vitamins in managing anemia. Ultimately, the positive outcomes we identified were closely tied to vitamin B12 administration rather than folate acting independently.
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9.5
We investigated how vitamin B12 treatment plays a role in addressing anemia in a young adolescent with complex health issues, including severe anemia, joint problems, and neurological symptoms. This individual presented with a deficiency in vitamin B12, alongside other autoimmune conditions, leading to a diagnosis of subacute combined degeneration of the spinal cord.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
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9
We evaluated the effectiveness of a grassroots organization’s iron and folic acid (IFA) supplementation program aimed at improving anemia levels among school-age and adolescent females in India. The program implemented a peer network approach to educate young females about anemia and encourage compliance with supplementation.
Participants in the study received a one-time anti-helminthic treatment, followed by weekly IFA tablets containing varying amounts of elemental iron and folic acid, based on age groups. Over the four-month period, we assessed hemoglobin levels before and after supplementation to determine its impact.
While the combination of iron and folic acid treatments has been recognized for its beneficial effects in fighting anemia, this specific program highlights the vital role of community-driven initiatives in enhancing health outcomes. Our findings suggest that while iron supplementation alone can have noticeable effects, isolating the specific benefits of folic acid within this context remains challenging.
Ultimately, we believe the involvement of grassroots organizations is crucial in raising awareness and improving compliance with nutritional supplementation programs, thereby helping to combat anemia effectively among children.
Participants in the study received a one-time anti-helminthic treatment, followed by weekly IFA tablets containing varying amounts of elemental iron and folic acid, based on age groups. Over the four-month period, we assessed hemoglobin levels before and after supplementation to determine its impact.
While the combination of iron and folic acid treatments has been recognized for its beneficial effects in fighting anemia, this specific program highlights the vital role of community-driven initiatives in enhancing health outcomes. Our findings suggest that while iron supplementation alone can have noticeable effects, isolating the specific benefits of folic acid within this context remains challenging.
Ultimately, we believe the involvement of grassroots organizations is crucial in raising awareness and improving compliance with nutritional supplementation programs, thereby helping to combat anemia effectively among children.
Read More
User Reviews
USERS' SCORE
Good
Based on 22 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced anemia symptoms
10 people found this helpful
Folic acid is touted as beneficial for pregnant women, and I found it cheaper to buy here. Having suffered from iron deficiency for decades, taking this alongside iron finally eliminated my anemia. I wish I had discovered it sooner; its effects are remarkable for both physical and mental health!
Read More
10
Stable hemoglobin
1 people found this helpful
I would buy again. After taking it, my haemoglobin levels are stable and there's no sign of anaemia, thanks to B12.
Read More
9
Effective results
1 people found this helpful
Prescribed by my sister's gynaecologist for conception, I know that folic acid addresses a deficiency in the body and is vital for overcoming anemia. I’m pleased with the packaging and the noticeable results.
Read More
9
Cured anaemia
1 people found this helpful
Cheap and functional. This is one of the best deals on folic acid, and switching to a folic with B12 cured my anaemia. As I must take folic (I’m on MTX), the fact that these are small, inexpensive and contain the B12 I need is great.
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9
Very effective improvement
This product significantly improves anemia and supplements folic acid; the results are very good.
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Frequently Asked Questions
7.5
Increased energy
10 people found this helpful
Folic acid, a B vitamin (B9), is used to address a deficiency in the body and is beneficial for anemia during pregnancy, unbalanced nutrition, and in infancy. I found these dietary supplements very effective. When combined with an iron supplement, I noticed a significant increase in my energy levels.
10
Stable hemoglobin
1 people found this helpful
I would buy again. After taking it, my haemoglobin levels are stable and there's no sign of anaemia, thanks to B12.
7.5
Normalising health issues
1 people found this helpful
I have no complaints. This bottle of tiny Folic Acid pills seems to be effectively helping with my health problems, especially regarding anemia.
7.5
Convenient and effective
2 people found this helpful
I have trouble with blood production and have been diagnosed with anaemia annually. To improve my condition, I take iron and buy folic acid for better absorption. It’s vital for iron absorption and recovery, and I highly recommend it!
9
Reduced anemia symptoms
10 people found this helpful
Folic acid is touted as beneficial for pregnant women, and I found it cheaper to buy here. Having suffered from iron deficiency for decades, taking this alongside iron finally eliminated my anemia. I wish I had discovered it sooner; its effects are remarkable for both physical and mental health!
7.5
Positive experience
2 people found this helpful
It’s easy to take as small grains, and when my menstruation starts, I sometimes experience anaemia. Since I began taking this, I haven’t felt faint during that time. I find it effective!
7.5
Long-term treatment
1 people found this helpful
I take Folic Acid, 800 mcg, in combination with iron for the treatment of anaemia, 1 tablet every other day. A jar of 250 tablets lasts a long time, which is convenient.
7.5
Daily supplement
1 people found this helpful
I highly recommend this product, particularly for those suffering from anaemia, as well as for women, especially pregnant women. Taking one pill daily is advisable.
4
We investigated how well women in East Africa comply with iron-folic acid (IFA) supplementation during pregnancy and its effects on anemia after childbirth. Analyzing data from over 43,000 women, we found that even with widespread IFA supplementation, anemia persists due to low compliance rates. This suggests that simply providing supplements isn't enough; we need to consider individual and socio-economic factors to improve adherence. Further studies will be essential in understanding how to effectively promote IFA supplementation and tackle anemia in this region.
9.5
We assessed how nutrition education, combined with iron-folic acid supplementation, impacts hemoglobin levels and adherence to supplementation among pregnant women in Ethiopia. Over three months, pregnant women received community-based education and were given supplements for six weeks.
The results were promising! After the intervention, anemia rates fell significantly from 27.8% to 7.2% among those who received education. Moreover, those participants showed much higher adherence to the supplementation compared to those who did not, suggesting that combining education with iron-folic acid intake can effectively improve health outcomes for pregnant women.
The results were promising! After the intervention, anemia rates fell significantly from 27.8% to 7.2% among those who received education. Moreover, those participants showed much higher adherence to the supplementation compared to those who did not, suggesting that combining education with iron-folic acid intake can effectively improve health outcomes for pregnant women.
4
Effects of supplementation on anemia
We explored how different regimens of iron-folic acid supplementation influence anemia and pregnancy outcomes. In our analysis of 22 trials involving pregnant women, we found that although maternal hemoglobin levels were slightly lower with intermittent regimens, the difference was not significant when it came to anemia incidence.
Notably, the intermittent regimen resulted in fewer gastric side effects and improved adherence to the treatment. Ultimately, while both approaches had their merits, the intermittent regimen showed distinct advantages during pregnancy without significantly reducing anemia rates.
Notably, the intermittent regimen resulted in fewer gastric side effects and improved adherence to the treatment. Ultimately, while both approaches had their merits, the intermittent regimen showed distinct advantages during pregnancy without significantly reducing anemia rates.
References
- Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. doi:10.1016/S2214-109X(24)00559-X
- Engidaw MT, Lee P, Ahmed F. Iron and folic acid supplementation compliance during pregnancy and its effect on post-pregnancy anaemia among reproductive-age women in East Africa. Womens Health (Lond). 2025;21:17455057251317547. doi:10.1177/17455057251317547
- Williams BA, McCartney H, Singer J, Devlin AM, Vercauteren S, et al. Folic acid supplementation in children with sickle cell disease: a randomized double-blind noninferiority cross-over trial. Am J Clin Nutr. 2025;121:910. doi:10.1016/j.ajcnut.2025.02.001
- Anato A, Reshid M. Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study. Sci Rep. 2025;15:3556. doi:10.1038/s41598-025-87957-x
- Aziz Ali S, Genkinger J, Kahe K, Valeri L, Khowaja N, et al. Role of preconception nutrition supplements in maternal anemia and intrauterine growth: a systematic review and meta-analysis of randomized controlled trials. Syst Rev. 2025;14:11. doi:10.1186/s13643-024-02726-7
- Bolka A, Bosha T, Gebremedhin S. Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study. Food Nutr Bull. 2025. doi:10.1177/03795721241304475
- Chillo SL, Woldesemayat EM, Dangisso MH. Intermittent versus daily oral iron folic acid supplementation and pregnancy outcome in low- and middle-income countries: a systematic review and meta-analysis of experimental studies. Reprod Health. 2025;22:2. doi:10.1186/s12978-024-01917-8
- Zhou J, Wang Q, Yu Y, Chen L, Shi J, et al. A rare case report of severe aplastic anaemia caused by long-term use of zidovudine. BMC Infect Dis. 2024;24:1421. doi:10.1186/s12879-024-09875-z
- Singh G, Ranjitha R, Baskaran P, Goel AD, Gupta MK, et al. Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study. Indian J Public Health. 2024;68:495. doi:10.4103/ijph.ijph_844_23
- Zhang C, Cha R, Long K, Liu Y, Dong Y, et al. Functionalized Iron Oxide Nanoparticles for Both Dual-Modal Imaging and Erythropoiesis. ACS Appl Mater Interfaces. 2024;16:68905. doi:10.1021/acsami.4c15206
- Behera DK, Rahut DB, Tripathy S, Negi S. Burden and causes of anemia in Vietnam: insights from the global burden of disease data. BMC Public Health. 2024;24:3026. doi:10.1186/s12889-024-20497-7
- Finkelstein JL, Cuthbert A, Weeks J, Venkatramanan S, Larvie DY, et al. Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev. 2024;8:CD004736. doi:10.1002/14651858.CD004736.pub6
- Merga RT, Birhane M, Dhinsa M, Muleta B, Jemal J, et al. Determinants of compliance with iron-folic acid supplementation among pregnant mothers in Bule Hora district, Southern Ethiopia: unmatched case-control study. BMC Public Health. 2025;25:832. doi:10.1186/s12889-025-22005-x
- Weeks CJ, Mian M, Stokes M, Gold M, Shah A, et al. The Role of Ferritin and Folate in Determining Stem Cell Collection for Autologous Stem Cell Transplant in Multiple Myeloma. Hematol Rep. 2025;17. doi:10.3390/hematolrep17010005
- Taye M, Mohammed T, Taye W, Glagn M, Yihune M. Compliance with iron-folate supplementation among pregnant women in Southern Ethiopia: a multi-center cross-sectional study. Reprod Health. 2025;22:22. doi:10.1186/s12978-025-01944-z
- Kant SB, Bashir R, Khan B, Shabbir NA, Nizami AA, et al. A Cross-Sectional Study of the Maternal Health Factors: The Interplay Between Breastfeeding Patterns, Gut Microbiota, Anemia, and Cardiovascular Risk in Lactating Mothers. Cureus. 2024;16:e76316. doi:10.7759/cureus.76316
- Belhaj R, Maaloul I, Kolsi R, Rekik T, Chabchoub I, et al. Study of clinical manifestations and etiologies of megaloblastic anemia in children. Transfus Clin Biol. 2025. doi:10.1016/j.tracli.2025.01.006
- Moreira AP, Vasconcelos M, Costa E Silva T, Relvas C, Espírito Santo J. An Unusual Case of Hemolytic Anemia: A Case Report. Cureus. 2024;16:e75676. doi:10.7759/cureus.75676
- Kataria S, Kataria S, Chougule D, Bharti B, Rastogi A. Evaluating the Impact of an Iron Supplementation Program for Combating Anemia in School-Age and Adolescent Females by a Grassroots Organization in India. Cureus. 2024;16:e75608. doi:10.7759/cureus.75608
- Kaneko M, Masuda Y, Ishikawa K, Shikata H. Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection. Cureus. 2024;16:e75257. doi:10.7759/cureus.75257
- Contreras R, Méndez GP, Mujica J, Padilla C, Selamé ME, et al. [Paroxysmal Nocturnal Hemoglobinuria: A Rare but Treatable Cause of Acute Kidney Injury. Case Report]. Rev Med Chil. 2024;152:627. doi:10.4067/s0034-98872024000500627
- Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4
- Sachdeva M, Purohit A, Malik M, Jain L, Pradhan P, et al. Comparison of Efficacy and Safety of Parenteral vs Oral Route of Vitamin B12 Supplementation for the Treatment of Vitamin B12 Deficiency Anemia in Children: A Systematic Review. Nutr Rev. 2025. doi:10.1093/nutrit/nuae227
- Obeid R, Geisel J, Pietrzik K, Andres E. A Framework to Guide Defining an Upper Threshold of Crystalline Vitamin B12 in Foods and Food Supplements. Curr Nutr Rep. 2025;14:32. doi:10.1007/s13668-025-00622-7
- Hirakata K, Ishii Y, Yoshida T, Tanaka F, Nakae Y. [A case of diagnosed pernicious anemia and subacute combined degeneration of the spinal cord with abnormally elevated serum vitamin B12]. Rinsho Shinkeigaku. 2025;65:120. doi:10.5692/clinicalneurol.cn-002023
- Goncalves H, De Oliveira Simões F, Sá R, Fraga Campos B, Domingues RM, et al. Severe Symptomatic Anemia as a Rare Initial Manifestation of Type 3 Polyglandular Autoimmune Syndrome: A Case Report. Cureus. 2024;16:e75800. doi:10.7759/cureus.75800
- Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. doi:10.1186/s12887-024-05262-4
- Tavares Pereira J, Barbosa Barroso J, Azevedo A, Ribeiro A, Tonel C. Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency. Cureus. 2024;16:e73620. doi:10.7759/cureus.73620
- Jamil M, Nasser Z, Jamil D, Sheqwara JZ. Unmasking Vitamin B12 Deficiency Misdiagnosed as Myelodysplastic Syndrome. Case Rep Hematol. 2024;2024:3258227. doi:10.1155/2024/3258227
- Memon NM, Conti G, Brilli E, Tarantino G, Chaudhry MNA, et al. Comparative bioavailability study of supplemental oral Sucrosomial vs. oral conventional vitamin B12 in enhancing circulatory B12 levels in healthy deficient adults: a multicentre, double-blind randomized clinical trial. Front Nutr. 2024;11:1493593. doi:10.3389/fnut.2024.1493593
