Overview
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.9
USERS' SCORE
Good
Based on 7 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%
Top Medical Research Studies
9
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Read More
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
Read More
7
We investigated the impact of folic acid (FA) on anxiety and ovarian function in female mice exposed to radiation. By dividing the mice into groups treated with FA and others that weren’t, we observed that those receiving FA showed significantly reduced anxiety levels alongside improvements in ovarian health. The findings highlighted that FA not only supports reproductive performance by preserving ovarian function but may also help manage emotional symptoms linked to radiation exposure. This suggests that folic acid could be a beneficial aid for women undergoing radiation therapy.
Read More
Most Useful Reviews
10
Life changer
65 people found this helpful
This vitamin has transformed my life. I have experienced no mood swings, anxiety or stress since switching to this product. It's a fantastic supplement and I recommend it to anyone looking for something natural that truly works!
Read More
9
Calms nervous system
I recommend it to anyone awaiting a miracle. I was advised by my doctor to take this, and I feel that my nervous system has calmed down, which has significantly reduced my anxiety. I suggest it to others.
Read More
9
Effective remedy
The product is excellent with great quality and a generous quantity. Folic acid improves many bodily functions including energy levels. It has immensely helped me calm my nervous system and alleviated issues like psychological distress, nervousness, headaches, depression, anxiety, and tension. I find it very safe.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 17 Researches
6.9
- All Researches
9
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Read More
8
We explored the effects of chlorzoxazone and folic acid on anxiety and cognitive functions in mice suffering from spinocerebellar ataxia type 3 (SCA3).
By administering these treatments, we found that while both chlorzoxazone and the combination with folic acid improved motor skills, only the combination significantly reduced anxiety and enhanced memory.
This highlights the potential of combination therapies in addressing both cognitive deficits and emotional symptoms associated with this condition.
By administering these treatments, we found that while both chlorzoxazone and the combination with folic acid improved motor skills, only the combination significantly reduced anxiety and enhanced memory.
This highlights the potential of combination therapies in addressing both cognitive deficits and emotional symptoms associated with this condition.
Read More
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
Read More
8
We aimed to understand how vitamin B12 might influence anxiety levels in individuals with fibromyalgia (FM), a condition often characterized by widespread pain and psychological distress.
During our study, we followed FM patients who were given 1000 mcg of vitamin B12 daily for 50 days. To gauge the effects, we compared various measurements taken before and after the treatment, including levels of anxiety and overall health.
The results were promising! We observed significant improvements in anxiety scores among participants after completing the vitamin B12 regimen. This suggests that vitamin B12 could be an effective addition to the treatment plan for those struggling with FM and anxiety.
Given these findings, we believe vitamin B12 holds strong potential as a complementary therapy for FM patients. Enhancing mood and reducing anxiety symptoms could greatly improve their quality of life.
During our study, we followed FM patients who were given 1000 mcg of vitamin B12 daily for 50 days. To gauge the effects, we compared various measurements taken before and after the treatment, including levels of anxiety and overall health.
The results were promising! We observed significant improvements in anxiety scores among participants after completing the vitamin B12 regimen. This suggests that vitamin B12 could be an effective addition to the treatment plan for those struggling with FM and anxiety.
Given these findings, we believe vitamin B12 holds strong potential as a complementary therapy for FM patients. Enhancing mood and reducing anxiety symptoms could greatly improve their quality of life.
Read More
7
We examined the effects of long-term folic acid treatment on chronic inflammatory pain and associated anxiety in rats. By injecting adjuvant into the rats’ hindpaw, we created a model to study pain behavior. Our findings showed that folic acid effectively reduced expressions of MMP2, a protein linked to inflammation, resulting in significant pain relief and lowering anxiety levels among the subjects. Overall, this study suggests that folic acid could be a beneficial treatment option for chronic inflammatory pain coupled with anxiety.
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User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
10
Life changer
65 people found this helpful
This vitamin has transformed my life. I have experienced no mood swings, anxiety or stress since switching to this product. It's a fantastic supplement and I recommend it to anyone looking for something natural that truly works!
Read More
9
Calms nervous system
I recommend it to anyone awaiting a miracle. I was advised by my doctor to take this, and I feel that my nervous system has calmed down, which has significantly reduced my anxiety. I suggest it to others.
Read More
9
Effective remedy
The product is excellent with great quality and a generous quantity. Folic acid improves many bodily functions including energy levels. It has immensely helped me calm my nervous system and alleviated issues like psychological distress, nervousness, headaches, depression, anxiety, and tension. I find it very safe.
Read More
8
Improves anxiety
Taking folic acid with B12 and various other vitamins can enhance depression and anxiety. This is based on a YouTuber's introduction, and you can consider incorporating it into your diet.
Read More
7.5
Reduces restlessness
Folic acid and vitamin B12 are vital components for the hematopoietic system. They also support the normal function of the nervous system and help alleviate emotional restlessness and anxiety. Due to work-related stress, folic acid helps me remain calm.
Read More
Frequently Asked Questions
10
Life changer
65 people found this helpful
This vitamin has transformed my life. I have experienced no mood swings, anxiety or stress since switching to this product. It's a fantastic supplement and I recommend it to anyone looking for something natural that truly works!
9
Calms nervous system
I recommend it to anyone awaiting a miracle. I was advised by my doctor to take this, and I feel that my nervous system has calmed down, which has significantly reduced my anxiety. I suggest it to others.
9
Effective remedy
The product is excellent with great quality and a generous quantity. Folic acid improves many bodily functions including energy levels. It has immensely helped me calm my nervous system and alleviated issues like psychological distress, nervousness, headaches, depression, anxiety, and tension. I find it very safe.
6
Relieves anxiety
45 people found this helpful
I became pregnant naturally in my 40s after taking Japanese folic acid supplements during my infertility treatment in my 30s. I had five failed attempts at IVF, which were incredibly stressful and filled me with anxiety. Transitioning to this product has given me hope and helped me maintain a positive outlook, even after a miscarriage. This routine has improved my financial, physical, and mental wellbeing.
8
Improves anxiety
Taking folic acid with B12 and various other vitamins can enhance depression and anxiety. This is based on a YouTuber's introduction, and you can consider incorporating it into your diet.
7.5
Reduces restlessness
Folic acid and vitamin B12 are vital components for the hematopoietic system. They also support the normal function of the nervous system and help alleviate emotional restlessness and anxiety. Due to work-related stress, folic acid helps me remain calm.
7
Folic acid alleviates nicotine withdrawal symptoms
We explored how folic acid (FA) could ease anxiety and depression in adolescent male rats going through nicotine withdrawal.
In the study, the rats were divided into groups, some receiving nicotine and others receiving various doses of FA.
The results showed that FA treatment significantly reduced anxiety and depressive-like behaviors associated with nicotine withdrawal.
This effect might be linked to FA’s ability to balance important biochemical processes in the brain. However, more research is needed to fully understand how this works.
In the study, the rats were divided into groups, some receiving nicotine and others receiving various doses of FA.
The results showed that FA treatment significantly reduced anxiety and depressive-like behaviors associated with nicotine withdrawal.
This effect might be linked to FA’s ability to balance important biochemical processes in the brain. However, more research is needed to fully understand how this works.
7
We explored how folate supplementation might counteract anxiety-like behaviors caused by prenatal ethanol exposure in rodents. Administering folate alongside ethanol during crucial developmental days showed promising results.
We found that while ethanol exposure led to adverse effects like reduced body weight and altered activity, folate administration significantly mitigated these issues. Specifically, folate improved behaviors related to anxiety and reduced shelter-seeking tendencies.
Overall, our study suggests that folate could be a beneficial and safe treatment option for addressing the neurobehavioral impacts of prenatal ethanol exposure.
We found that while ethanol exposure led to adverse effects like reduced body weight and altered activity, folate administration significantly mitigated these issues. Specifically, folate improved behaviors related to anxiety and reduced shelter-seeking tendencies.
Overall, our study suggests that folate could be a beneficial and safe treatment option for addressing the neurobehavioral impacts of prenatal ethanol exposure.
9
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
7
We explored the impact of folic acid (FA) on anxiety and mood disorders, particularly in a mouse model that simulates early immune challenges.
Our findings suggest that FA treatment can significantly improve anxiety and depressive behaviors in adult mice, likely by reducing the activation of certain brain cells called glial cells.
Alongside these behavioral improvements, we noted reduced inflammation in the brain areas related to mood and stress. Importantly, the study highlights different ways FA functions in two types of glial cells and its potential as a treatment for mood disorders stemming from early neurodevelopmental issues.
Our findings suggest that FA treatment can significantly improve anxiety and depressive behaviors in adult mice, likely by reducing the activation of certain brain cells called glial cells.
Alongside these behavioral improvements, we noted reduced inflammation in the brain areas related to mood and stress. Importantly, the study highlights different ways FA functions in two types of glial cells and its potential as a treatment for mood disorders stemming from early neurodevelopmental issues.
References
- Ni WH, Wang K, Wang Y, Lu J, Lu CT, et al. Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats. Neuropharmacology. 2025;269:110352. doi:10.1016/j.neuropharm.2025.110352
- Marinina KS, Bezprozvanny IB, Egorova PA. A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice. Hum Mol Genet. 2024;33:1406. doi:10.1093/hmg/ddae079
- Rezaei Moghadam M, Khoshrou A, Kakhki S, Hosseini SH, Shirinzadeh Feizabadi A, et al. Folic Acid Ameliorates Anxiety- and Depressive-Like Behavior Induced by Nicotine Withdrawal Through Restoration of Behavioral and Biochemical Alterations in Adolescent Male Rats. Nicotine Tob Res. 2024;26:733. doi:10.1093/ntr/ntad227
- Marengo L, Barey A, Salguero A, Fabio MC, Cendán CM, et al. Neurobehavioral alterations induced by third-trimester gestation-equivalent ethanol exposure are inhibited by folate administration. Dev Psychobiol. 2023;65:e22426. doi:10.1002/dev.22426
- Kakhki S, Goodarzi M, Abbaszade-Cheragheali A, Rajabi M, Masoumipour AH, et al. Folic acid supplementation improved cognitive deficits associated with lithium administration during pregnancy in rat offspring. Int J Dev Neurosci. 2023;83:615. doi:10.1002/jdn.10289
- Shemirani F, Titcomb TJ, Saxby SM, Eyck PT, Rubenstein LM, et al. Association of serum homocysteine, folate, and vitamin B and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial. Mult Scler Relat Disord. 2023;75:104743. doi:10.1016/j.msard.2023.104743
- Zhang Q, Wei Z, Weng H, Chen Y, Zhang J, et al. Folic Acid Preconditioning Alleviated Radiation-Induced Ovarian Dysfunction in Female Mice. Front Nutr. 2022;9:854655. doi:10.3389/fnut.2022.854655
- Ono T, Hino K, Kimura T, Uchimura Y, Ashihara T, et al. Excessive folic acid intake combined with undernutrition during gestation alters offspring behavior and brain monoamine profiles. Congenit Anom (Kyoto). 2022;62:169. doi:10.1111/cga.12472
- Zhao T, Wu D, Du J, Liu G, Ji G, et al. Folic Acid Attenuates Glial Activation in Neonatal Mice and Improves Adult Mood Disorders Through Epigenetic Regulation. Front Pharmacol. 2022;13:818423. doi:10.3389/fphar.2022.818423
- Eszlari N, Bruncsics B, Millinghoffer A, Hullam G, Petschner P, et al. Biology of Perseverative Negative Thinking: The Role of Timing and Folate Intake. Nutrients. 2021;13. doi:10.3390/nu13124396
- Zhang Q, Huang Q, Yao L, Liu W, Ruan J, et al. Gestational Folic Acid Administration Alleviated Maternal Postpartum Emotional and Cognitive Dysfunction in Mice. Front Pharmacol. 2021;12:701009. doi:10.3389/fphar.2021.701009
- Mahdavifar B, Hosseinzadeh M, Salehi-Abargouei A, Mirzaei M, Vafa M. Dietary intake of B vitamins and their association with depression, anxiety, and stress symptoms: A cross-sectional, population-based survey. J Affect Disord. 2021;288:92. doi:10.1016/j.jad.2021.03.055
- de Carvalho J, Lerner A, Feingold D. Management of Hyperhomocysteinemia, Low Vitamin Levels, and Low Cortisol in Cannabis Users: A Report of 2 Cases. J Chiropr Med. 2022;21:322. doi:10.1016/j.jcm.2022.03.001
- Nahar M, Rai R, Jat D. Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach. Int J Neurosci. 2024. doi:10.1080/00207454.2024.2398564
- Hu Y, Yu M, Wang Y, Wu H, Yang X, et al. Exploring the Association between Serum B Vitamins, Homocysteine and Mental Disorders: Insights from Mendelian Randomization. Nutrients. 2024;16. doi:10.3390/nu16131986
- Tan Y, Zhou L, Huang J, Chen X, Wu Y, et al. Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms. Neuropsychiatr Dis Treat. 2023;19:785. doi:10.2147/NDT.S399378
- Gharibpoor F, Ghavidel-Parsa B, Sattari N, Bidari A, Nejatifar F, et al. Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study. BMC Rheumatol. 2022;6:51. doi:10.1186/s41927-022-00282-y
