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SCIENTIFIC SCORE
Moderately Effective
Based on 1 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.7
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Zinc(from 270 mg Zinc Picolinate)
50 mg
455%
Top Medical Research Studies
8
Zinc may mitigate granisetron constipation
Carbon monoxide contributes to the constipating effects of granisetron in rat colon.
Specific interaction with granisetron
We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Read More
Most Useful Reviews
9.5
Improved digestion
The quality of this supplement is excellent. The balanced ingredients have improved my health as they contain natural substances. The capsules are conveniently sized and easy to swallow, with a neutral taste. It has notably helped my digestion and alleviated constipation. I highly recommend purchasing it!
Read More
9.5
Reduced breakouts
Zinc picolinate has strengthened my immune system. Since taking it, I’ve experienced fewer colds and improved skin. My acne has diminished considerably, and the condition of my skin has become smoother. This form of zinc is well absorbed and has greatly aided my constipation. I recommend it!
Read More
9.5
Improved microbiome
Zinc picolinate is top quality, with great ingredients. My health has improved, and I’ve noticed noticeable benefits such as better digestion and a healthier microbiome. It has effectively addressed my constipation and contributed to my overall wellbeing.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Researches
8
8
Zinc may mitigate granisetron constipation
Carbon monoxide contributes to the constipating effects of granisetron in rat colon.
Specific interaction with granisetron
We investigated how zinc might play a role in alleviating the constipation effects caused by granisetron, a medication often used to prevent nausea. In the studies, male rats were treated with varying doses of granisetron, alongside zinc protoporphyrin IX (ZnPPIX), to see how these compounds interacted.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Interestingly, while granisetron was found to increase the time to first defecation in the rats, ZnPPIX alone did not have a notable effect on constipation. However, when combined with granisetron, ZnPPIX successfully reversed the constipation induced by this medication. This suggests that zinc, acting through the heme oxygenase/carbon monoxide (HO/CO) pathway, could potentially mitigate constipation.
Nonetheless, it’s crucial to note that ZnPPIX’s effectiveness was only observed when paired with granisetron; its standalone administration didn’t significantly alter gastrointestinal motility. This highlights a specific interaction rather than a general benefit of zinc in treating constipation.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.5
Improved digestion
The quality of this supplement is excellent. The balanced ingredients have improved my health as they contain natural substances. The capsules are conveniently sized and easy to swallow, with a neutral taste. It has notably helped my digestion and alleviated constipation. I highly recommend purchasing it!
Read More
9.5
Reduced breakouts
Zinc picolinate has strengthened my immune system. Since taking it, I’ve experienced fewer colds and improved skin. My acne has diminished considerably, and the condition of my skin has become smoother. This form of zinc is well absorbed and has greatly aided my constipation. I recommend it!
Read More
9.5
Improved microbiome
Zinc picolinate is top quality, with great ingredients. My health has improved, and I’ve noticed noticeable benefits such as better digestion and a healthier microbiome. It has effectively addressed my constipation and contributed to my overall wellbeing.
