In a double-blind study, we aimed to see how zinc treatments could influence the immune response to varicella-zoster virus, particularly in older adults. Thirty volunteers over the age of 70 received either the live varicella vaccine or a placebo after a four-week period where they were pretreated with zinc acetate or a placebo.
We noted that while the elderly participants initially showed a decreased response to varicella-specific antigens, their general skin reactivity to common bacterial antigens remained normal. However, after repeated skin testing, we observed that their varicella-specific responses became significantly stronger, making it difficult to isolate the effects of zinc or the vaccination.
Interestingly, we found no significant changes in the specific antibody levels across the groups, indicating that zinc's role in enhancing the immune response to shingles might be limited. Overall, it seems that the elderly population does retain the capability to respond to immunizations, but the speed at which that response occurs may slow down, which could be linked to the increased incidence of shingles in this age group.
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