Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
Read More
7
Magnesium affects anxiety via gut bacteria
Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria.
We examined the link between magnesium oxide and anxiety-like behavior in mice. The research focused on how a specific type of bacteria in the gut, known as sulfate-reducing bacteria (SRB), might contribute to anxiety. When we introduced these bacteria into the mice, they exhibited increased signs of anxiety, which we measured using a test called the open field test.
Next, we explored the effect of magnesium oxide on the growth of these bacteria in both lab settings and in real-life scenarios involving psychological stress, specifically using a water avoidance stress model. Remarkably, we found that magnesium oxide effectively inhibited the growth of SRB and the production of a byproduct called hydrogen sulfide in a dose-dependent manner.
Mice subjected to stress developed an overgrowth of SRB and displayed amplified anxiety-like behavior. However, those fed a magnesium oxide-enriched diet showed reduced levels of both SRB and anxiety. Our findings suggest that magnesium may play a significant role in mitigating anxiety by altering gut bacteria dynamics.
Read More
5
Magnesium's effects on anxiety examined
The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms.
We investigated how magnesium sulfate affects anxiety-like behaviors and memory in male rats suffering from induced anxiety through exposure to predator odor. By using a series of behavioral tests alongside a comparison to diazepam—an established anxiolytic medication—we aimed to assess the potential benefits of magnesium treatment in managing anxiety.
Our findings revealed that magnesium did provide some anxiolytic effects, but it fell short compared to diazepam, especially regarding its impact on anxiety. Interestingly, we noticed that the response to magnesium varied depending on the dosage used. In addition to these behavioral observations, we also examined changes in oxidative stress and nitric oxide levels in the brain, suggesting that magnesium treatment has the potential to counteract increased oxidative stress that comes with anxiety.
This research adds to the understanding of magnesium's role in anxiety management, highlighting its ability to modulate oxidative stress, although further studies will be required to fully grasp its effects and optimize its application in anxiety disorders.
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Most Useful Reviews
9
Reduced anxiety levels
3 people found this helpful
Excellent! I suffer from migraines and coeliac disease, which aggravates my episodes. After starting magnesium, my migraines have significantly reduced and are now more sporadic. Additionally, my anxiety levels have decreased, and I feel more energetic and capable, which is crucial since I often experience fatigue due to my condition. I recommend it. If you find this review helpful, please like it.
Read More
9
Reduced stress symptoms
2 people found this helpful
Magnesium Malate aids in reducing stress, anxiety, and depression. It is also effective against heart arrhythmias, chest pain, and chronic fatigue, while alleviating muscle pain from fibromyalgia. Additionally, it enhances memory and combats insomnia.
Read More
9
Less anxiety felt
This is an excellent magnesium for nervous system health! My headaches and leg cramps have ceased. I feel much better, and my excessive anxiety and chest heaviness have vanished. The pills are a bit large for me, but I am very satisfied with the results.
We examined how magnesium, in combination with ibogaine, affects anxiety in veterans with traumatic brain injuries. This was part of a larger study focusing on the wellbeing of Special Operations Forces veterans, who often suffer from mental health issues like anxiety and PTSD after experiencing head trauma.
The study involved 30 male veterans, primarily with mild brain injuries. Researchers used various assessments, including scales for anxiety, to measure changes before treatment and then again one month afterward. The findings were promising, showing considerable improvements in anxiety levels, as well as in depression and PTSD symptoms.
However, it’s important to note that since magnesium was administered alongside ibogaine, we can’t isolate the effects of magnesium alone on anxiety. Although the results were encouraging, we need more controlled clinical trials to fully understand the safety and effectiveness of magnesium treatment on its own.
Overall, while magnesium may play a role in improving anxiety, further research is essential to clarify its specific impact without the influence of other treatments.
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8
Magnesium's role in anxiety treatment
Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study.
We explored the effects of magnesium sulfate and labetalol on managing pregnancy-induced hypertension (PIH) and their potential influence on anxiety and depression among patients. In our study, we examined data from patients diagnosed with PIH from July 2020 to July 2023 at two hospitals in Chengdu, China.
Among the 219 participants, we found that 36.1% experienced anxiety and depression. We divided patients into two groups based on treatment: one group received magnesium sulfate and labetalol, while the other group received standard treatment. It was notable that those in the magnesium sulfate and labetalol group reported significant improvements in anxiety and depression levels, as measured by the Edinburgh Postnatal Depression Scale and the Generalized Anxiety Disorder 7 scale.
However, when evaluating blood pressure control, the effectiveness was similar across both groups, which means the treatment did not significantly impact blood pressure outcomes. Overall, this research points to the possibility that magnesium sulfate and labetalol can not only help manage high blood pressure in pregnant women but may also indirectly alleviate feelings of anxiety and depression.
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8
Magnesium aids post-surgery anxiety
Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study.
This study set out to understand how magnesium, combined with lidocaine, influences anxiety levels and postoperative pain in patients undergoing spine fusion surgery. We engaged 120 patients aged 18 to 60 and divided them into different groups, each receiving varying treatments, including a control group that received saline.
Importantly, we observed that the group receiving the combination of lidocaine and magnesium experienced lower anxiety and depression levels following surgery. Not only did this treatment seem to help in managing pain more effectively, but it also enhanced overall patient satisfaction three months after a single infusion.
While the study highlighted the synergistic effects of combining both medications, the specific impact of magnesium alone on anxiety isn't entirely clear. The results suggested that while magnesium played a role within the combination treatment, isolating its effect on anxiety wasn't feasible in this context.
Nonetheless, the findings are promising for those seeking alternatives to standard pain management that could include anxiety relief in the postoperative period. It opens up avenues for further research on magnesium’s individual role in emotional health.
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8
Magnesium reduces anxiety symptoms
Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat.
We investigated how magnesium might influence anxiety, particularly when triggered by oxidative stress from hydrogen peroxide. The study involved eighteen Wistar rats divided into three groups: a control group, a group treated with hydrogen peroxide, and a group receiving both hydrogen peroxide and magnesium sulphate.
Our findings revealed that the rats exposed to hydrogen peroxide exhibited increased anxiety and signs of oxidative damage in the brain. However, those that received magnesium showed significant improvements. They not only had reduced levels of anxiety but also demonstrated less oxidative stress.
This suggests that magnesium could play a beneficial role in counteracting anxiety and the negative effects of oxidative stress. Though the results are promising, it's important to remember that further research is needed to fully understand magnesium's potential effects on anxiety in humans.
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8
Magnesium treats anxiety in MS
Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
Excellent! I suffer from migraines and coeliac disease, which aggravates my episodes. After starting magnesium, my migraines have significantly reduced and are now more sporadic. Additionally, my anxiety levels have decreased, and I feel more energetic and capable, which is crucial since I often experience fatigue due to my condition. I recommend it. If you find this review helpful, please like it.
Read More
9
Reduced stress symptoms
2 people found this helpful
Magnesium Malate aids in reducing stress, anxiety, and depression. It is also effective against heart arrhythmias, chest pain, and chronic fatigue, while alleviating muscle pain from fibromyalgia. Additionally, it enhances memory and combats insomnia.
Read More
9
Less anxiety felt
This is an excellent magnesium for nervous system health! My headaches and leg cramps have ceased. I feel much better, and my excessive anxiety and chest heaviness have vanished. The pills are a bit large for me, but I am very satisfied with the results.
Read More
9
Improved calmness
I felt changes almost immediately; after 2-3 days, my sleep became peaceful, my rapid heartbeat vanished, and I no longer wake at night. The feeling of anxiety has gone, and my psychological state has become more relaxed. Most importantly, I no longer experience nightly calf cramps or spasms.
Read More
6
Calmed nerves
1 people found this helpful
Good magnesium; I take it regularly. It calms the nervous system and helps alleviate heightened anxiety. I have become a little calmer since starting this medication. As a schoolchild's mother, this has become an essential remedy for me. My reactions to events are now much easier to manage, and I can confidently recommend it.
Anxiety is a natural and often healthy emotion characterized by feelings of worry, nervousness, or fear about an impending event or situation. While some level of anxiety is a normal reaction to stress, excessive or chronic anxiety can become a mental health issue. It may present in various forms, from everyday worries to more severe conditions such as generalized anxiety disorder (GAD), panic disorder, or social anxiety disorder. Symptoms can manifest both psychologically, such as persistent worry and difficulty concentrating, and physically, including symptoms like increased heart rate, sweating, or fatigue.
Understanding the difference between normal anxiety and an anxiety disorder is crucial. Normal anxiety can be beneficial, motivating you to prepare for important events like exams or public speaking. However, when it starts to interfere with daily activities or leads to avoidance behaviors, it may indicate the need for professional help. Treatments for anxiety often include therapy, medications, and lifestyle changes, allowing individuals to manage their symptoms effectively. If someone is struggling with anxiety that impacts their quality of life, seeking guidance from a healthcare professional is a key step toward recovery.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium has been studied for its potential role in alleviating symptoms of anxiety, and some evidence suggests it may be beneficial. Magnesium plays a critical role in brain function and the regulation of neurotransmitters, which are essential for mood stability. Some studies have indicated that low levels of magnesium may be linked to increased anxiety symptoms, and supplementation could work to help improve overall mental health by restoring adequate magnesium levels. While it's not a standalone treatment for anxiety disorders, integrating magnesium into a balanced diet with other treatment modalities could provide additional support.
That said, it's important to approach magnesium supplementation thoughtfully. Overuse can lead to adverse effects, and individual needs may vary widely depending on dietary intake and overall health status. Before starting any new supplement, especially for managing anxiety, consulting with a healthcare professional is advisable to tailor an approach that aligns with your personal health needs. In summary, while magnesium can play a role in supporting anxiety management, it should complement traditional treatments rather than serve as a primary solution.
Based on user reviews, many individuals report experiencing a noticeable reduction in anxiety symptoms within a few days of starting magnesium supplementation. One user noted feeling improvements almost immediately, with significant changes occurring after just 2-3 days. This included a calmer emotional state and better sleep patterns Read Review. Another user echoed these sentiments, mentioning that their anxiety had diminished shortly after beginning their regimen Read Review.
However, experiences can vary, with some users taking a couple of weeks to fully notice the benefits. Several reviews highlight that consistent usage over time significantly enhances the effects, helping users achieve a calmer and better-balanced state amidst daily stressors Read Review. Overall, while many users see results quickly, the key takeaway is that regular, sustained use is important for maximized benefits.
While scientific research presents mixed findings, several studies indicate that magnesium could be a beneficial supplement for alleviating anxiety symptoms, particularly in specific populations or conditions. A systematic review encompassing 15 studies found that many participants reported improvements in anxiety levels through magnesium supplementation, especially those with initially low magnesium levels ([3]). Additionally, a randomized controlled trial noted significant reductions in anxiety during supplementation, though the long-term effects remain uncertain ([1]).
In animal studies, magnesium has demonstrated potential anxiolytic effects, influencing behaviors related to anxiety in mouse models ([2]). However, results vary and indicate that magnesium’s efficacy may depend on factors like dosage and specific health conditions, as seen in studies on migraine patients and those dealing with multiple sclerosis ([11]). Overall, while magnesium shows promise in potentially easing anxiety, more rigorous human trials are necessary to establish definitive conclusions and identify optimal dosages.
Users report a variety of symptom improvements when incorporating magnesium supplements into their routines. Many individuals have noted a significant reduction in anxiety levels, with one user mentioning a dramatic decline in anxiety and chest heaviness, leading to a calmer psychological state Read Review. Another noted that magnesium helped in coping with stress, resulting in a more manageable emotional reaction to daily events Read Review. Furthermore, users experiencing migraines have observed a decrease in episode frequency and intensity after starting magnesium supplementation, with one user mentioning their migraines have become more sporadic Read Review.
In addition to anxiety and headache relief, several users have reported improvements in their overall energy levels and sleep quality, describing experiences of feeling more energetic and less fatigued Read Review. One reviewer specifically highlighted restful sleep and the cessation of calf cramps as notable benefits, suggesting a comprehensive improvement in their health Read Review. While numerous users seem to experience these positive outcomes, it is important to remember that individual results can vary.
Users report positive experiences when combining magnesium supplements with other anxiety management strategies. Many individuals highlight the calming effects of magnesium on their nervous system, which aids in reducing symptoms of anxiety and stress. For instance, one user specifically mentioned that taking magnesium during anxiety episodes significantly improved their overall state—helping to subdue anxiety and enhance sleep quality, while also reducing headaches Read Review. Another review noted that using magnesium not only alleviated anxiety but also addressed other concerns such as leg cramps, creating a holistic improvement in health Read Review.
Furthermore, some users recommend considering additional supplements alongside magnesium for comprehensive anxiety management. One review emphasized the importance of incorporating magnesium daily, particularly in stressful times, suggesting that its regular intake could further bolster mental health by preventing anxiety buildup Read Review. This sentiment is echoed by those who report feeling calmer and more capable in everyday situations when magnesium is part of their daily routine Read Review. Overall, user reviews suggest that combining magnesium with a consistent anxiety management plan might yield the best results.
Users report varying doses of magnesium for treating anxiety, with some finding effective relief at doses of two to three tablets taken daily. One user mentioned that taking three tablets significantly reduced anxiety and improved sleep quality, suggesting that this dosage may work well for others as well Read Review. Another user emphasized the importance of regular consumption, indicating that magnesium should be replenished daily and doesn’t accumulate in the body, hinting at a consistent dosing strategy Read Review.
Additionally, many users expressed positive outcomes from magnesium supplements when addressing anxiety, noting improvements in overall mental health and reduced feelings of heaviness in the chest Read Review. However, it's noteworthy that some users also mentioned that they adjusted their intake, such as splitting pills in half for easier consumption Read Review. Though specific dosage suggestions varied, the common theme in the reviews indicates that finding the right dosage may depend on individual needs and responses to magnesium.
9
Improved calmness
I felt changes almost immediately; after 2-3 days, my sleep became peaceful, my rapid heartbeat vanished, and I no longer wake at night. The feeling of anxiety has gone, and my psychological state has become more relaxed. Most importantly, I no longer experience nightly calf cramps or spasms.
9
Less anxiety felt
This is an excellent magnesium for nervous system health! My headaches and leg cramps have ceased. I feel much better, and my excessive anxiety and chest heaviness have vanished. The pills are a bit large for me, but I am very satisfied with the results.
6
Calmed nerves
1 people found this helpful
Good magnesium; I take it regularly. It calms the nervous system and helps alleviate heightened anxiety. I have become a little calmer since starting this medication. As a schoolchild's mother, this has become an essential remedy for me. My reactions to events are now much easier to manage, and I can confidently recommend it.
9
Reduced anxiety levels
3 people found this helpful
Excellent! I suffer from migraines and coeliac disease, which aggravates my episodes. After starting magnesium, my migraines have significantly reduced and are now more sporadic. Additionally, my anxiety levels have decreased, and I feel more energetic and capable, which is crucial since I often experience fatigue due to my condition. I recommend it. If you find this review helpful, please like it.
7.5
Helps manage symptoms
Drinking magnesium during episodes of anxiety has proven effective for me. I find that when I take three tablets with plenty of water, my anxiety subsides, sleep improves, and I experience fewer headaches.
7.5
Reduced anxiety
Wonderful! Excellent magnesium for maintaining the health of the nervous system! Headaches and cramps in my legs have ceased to trouble me, and I feel much better. Simultaneously, the excessive anxiety and heaviness in my chest have disappeared. The pills are a bit large for me, so I split them in half, but I am pleased with the effect!
7.5
Essential for everyone
A must-have for everyone! In our stressful times, magnesium is essential on a daily basis. It doesn’t accumulate in the body and should be replenished regularly. This form is exceptional for relieving leg cramps and significantly reduces anxiety!
7
Magnesium shows potential for anxiety
Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review.
We conducted a systematic review to evaluate how magnesium might help with anxiety. As self-treatment with supplements grows in popularity, we focused on the clinical evidence surrounding magnesium’s effects on anxiety and sleep disorders.
Through our thorough search, we found 15 studies that fit our strict criteria. Most of these studies showed at least some improvement in either anxiety levels or sleep quality. In fact, five out of eight studies looking at sleep-related outcomes noted positive changes, while five out of seven studies focused on anxiety reported improvements in self-reported anxiety.
Despite the encouraging findings, we have to approach these results with caution. The studies varied in terms of dosage, formulation, and duration of magnesium treatment. Plus, some included other active ingredients that make it hard to know magnesium’s exact impact. Interestingly, two of the studies that didn’t show improvement involved populations with other health concerns, highlighting the need for further investigation.
Overall, it seems like magnesium might be a useful supplement for those dealing with mild anxiety, especially if they have low magnesium levels to begin with. However, larger and more rigorous trials are essential to truly confirm its effectiveness and determine the best types and doses for use.
7
Magnesium's transient anxiety relief
Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial.
In our quest to understand how magnesium influences anxiety, we conducted a randomized double-blind controlled trial involving 120 adults diagnosed with major depressive disorder (MDD). Participants took either a combination of probiotics, magnesium orotate, and coenzyme Q10 or a placebo for eight weeks.
At the end of the treatment period, we observed that those taking the combination showed significantly lower rates of major depressive episodes compared to those taking the placebo. However, this difference did not persist by the 8-week follow-up. While there was a notable reduction in self-reported symptoms of anxiety and stress during the treatment, this result also lacks long-term significance.
Ultimately, while our findings suggest that magnesium in combination with probiotics and coenzyme Q10 might help alleviate anxiety symptoms for a brief period, the persistent effects are unclear as we found no enduring benefits in the longer term.
7
Magnesium affects anxiety via gut bacteria
Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria.
We examined the link between magnesium oxide and anxiety-like behavior in mice. The research focused on how a specific type of bacteria in the gut, known as sulfate-reducing bacteria (SRB), might contribute to anxiety. When we introduced these bacteria into the mice, they exhibited increased signs of anxiety, which we measured using a test called the open field test.
Next, we explored the effect of magnesium oxide on the growth of these bacteria in both lab settings and in real-life scenarios involving psychological stress, specifically using a water avoidance stress model. Remarkably, we found that magnesium oxide effectively inhibited the growth of SRB and the production of a byproduct called hydrogen sulfide in a dose-dependent manner.
Mice subjected to stress developed an overgrowth of SRB and displayed amplified anxiety-like behavior. However, those fed a magnesium oxide-enriched diet showed reduced levels of both SRB and anxiety. Our findings suggest that magnesium may play a significant role in mitigating anxiety by altering gut bacteria dynamics.
8
Magnesium treats anxiety in MS
Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress.
We aimed to understand the impact of nanoparticulate magnesium hydride (MgH) on anxiety and depression associated with multiple sclerosis (MS). Our exploration involved studying how MgH affects mood disorders in a model we designed, specifically using experimental autoimmune encephalomyelitis (EAE) mice.
We discovered that MgH treatment significantly alleviated anxiety and depression-like behaviors in these mice. Not only did MgH help improve their mood, but it also reduced overall disease severity and inflammatory damage within the central nervous system.
Importantly, our findings suggest that MgH could be working by promoting healthier microglial activity. It appears to encourage the beneficial M2 polarization while inhibiting the harmful M1 polarization, alongside reducing oxidative stress. This mechanism offers a glimpse into how magnesium might truly enhance well-being for those dealing with MS-related psychiatric issues.
In summary, our research indicates that nanoparticulate MgH holds promise as a non-toxic and effective treatment option for anxiety and depression in people suffering from MS, showcasing a potential breakthrough in managing these debilitating conditions.
References
Strodl E, Bambling M, Parnam S, Ritchie G, Cramb S, et al. Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial. Sci Rep. 2024;14:20841. 10.1038/s41598-024-71093-z
Coffman CN, Carroll-Portillo A, Alcock J, Singh SB, Rumsey K, et al. Magnesium Oxide Reduces Anxiety-like Behavior in Mice by Inhibiting Sulfate-Reducing Bacteria. Microorganisms. 2024;12. 10.3390/microorganisms12071429
Rawji A, Peltier MR, Mourtzanakis K, Awan S, Rana J, et al. Examining the Effects of Supplemental Magnesium on Self-Reported Anxiety and Sleep Quality: A Systematic Review. Cureus. 2024;16:e59317. 10.7759/cureus.59317
Wang S, Zhang J, Zhu T, Xie X, Xia X, et al. Efficacy of Magnesium Sulfate and Labetalol in the Treatment of Pregnancy-Induced Hypertension and Its Effect on Anxiety and Depression: A Retrospective Cohort Study. Alpha Psychiatry. 2024;25:243. 10.5152/alphapsychiatry.2024.231342
Abdel Rady MM, Osman AM, Abo Elfadl GM, Ahmed HM, Sayed S, et al. Effects of intravenous single-bolus lidocaine infusion versus intravenous single-bolus magnesium sulfate infusion on postoperative pain, emotional status, and quality of life in patients undergoing spine fusion surgery: a randomized study. Minerva Anestesiol. 2024;90:397. 10.23736/S0375-9393.24.17868-6
Cetin A, Ozdemir E, Golgeli A, Taskiran AS, Karabulut S, et al. The effect of magnesium sulfate on memory and anxiety-like behavior in a rat model: an investigation of its neuronal molecular mechanisms. Neurol Res. 2024;46:752. 10.1080/01616412.2024.2352234
Mititelu-Tartau L, Bogdan M, Pavel LL, Rezus C, Foia CI, et al. Anxiolytic-like Activity, Antioxidant Properties, and Facilitatory Effects on the Short-Term Memory Retention of Molsidomine in Rats. Life (Basel). 2024;14. 10.3390/life14030306
Cherian KN, Keynan JN, Anker L, Faerman A, Brown RE, et al. Magnesium-ibogaine therapy in veterans with traumatic brain injuries. Nat Med. 2024;30:373. 10.1038/s41591-023-02705-w
Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. 10.3389/fnut.2023.1211321
Hajri L, Othman H, Ghodbane S, Sakly M, Abdelmelek H, et al. Neuroprotective effects of magnesium against stress induced by hydrogen peroxide in Wistar rat. Biomarkers. 2023;28:538. 10.1080/1354750X.2023.2246104
Li Z, Chen K, Shao Q, Lu H, Zhang X, et al. Nanoparticulate MgH ameliorates anxiety/depression-like behaviors in a mouse model of multiple sclerosis by regulating microglial polarization and oxidative stress. J Neuroinflammation. 2023;20:16. 10.1186/s12974-023-02696-y
Proskurnina EV, Liaukovich KM, Bychkovskaya LS, Mikheev IV, Alshanskaia EI, et al. Salivary Antioxidant Capacity and Magnesium in Generalized Anxiety Disorder. Metabolites. 2023;13. 10.3390/metabo13010073