NOW Supplements Omega-3

Eicosapentaenoic acid alleviates back pain

Based on 11 Researches

Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.

Most Relevant Research

We explored how eicosapentaenoic acid (EPA) might help in treating intervertebral disc degeneration (IDD), a major contributor to back pain. Research highlights that this condition often involves endoplasmic reticulum (ER) stress and breakdown of the extracellular matrix (ECM), key processes that worsen IDD. Our investigation demonstrated that EPA can promote autophagy, a process that helps cells clean up and maintain balance within the ECM.

Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.

In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.

9.5

Eased back pain

Most Useful Review

This vitamin is the best I have tried. As a chronic pain sufferer, I'm always looking for supplements to help. This one gives me an energy boost, and I am experiencing less back pain after taking it.

Heart Attack details

Eicosapentaenoic acid aids heart recovery

Eicosapentaenoic Acid Preserves Mitochondrial Quality and Attenuates Cardiac Remodeling After Myocardial Infarction in Rats.

Most Relevant Research

We investigated how eicosapentaenoic acid (EPA) may help improve heart health after a heart attack. In our study, we induced myocardial infarction (MI) in male rats by ligating their coronary artery. Some of these rats received daily treatment with EPA, while others did not, allowing us to compare the effects.

Over 12 weeks, we observed that the rats treated with EPA showed better left ventricular function—essentially, their hearts were working more efficiently. Moreover, these rats had higher levels of EPA in their mitochondria, which are the energy factories of cells. Despite the damage caused by the heart attack, the EPA treatment helped maintain crucial energy levels and kept the mitochondrial function from declining, preserving a specific protein linked to cellular health.

Our findings suggest that including EPA in the diet can bolster mitochondrial quality and support heart function after an MI. This could mean that EPA may serve as an important dietary addition for promoting heart health following heart events.

9.5

Heart attack prevention

Most Useful Review

I drink Omega-3 with lecithin, and it has significantly improved my heart health and sleep quality. At my age, staying well is crucial. My family has long-lived members, and I intend to live longer for my grandchildren. I highly recommend Omega-3!

Heart Disease details

Omega-3 lowers coronary risk

A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.

Most Relevant Research

We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.

Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.

This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.

8.8

Improved heart health

Most Useful Review

Quality product! This fish oil is excellent for health conscious individuals. It provides a good dose of fatty acids and comes from a reputable manufacturer. At 32, I take these capsules for my hair and skin. After various diets, fish oil has been a saviour: my skin is supple, and my hair is less damaged. My parents ordered it for heart disease; my mother, 55, noticed improvement in energy and skin condition. I recommend this product, taking 2 capsules 1-3 times daily with meals. The large capsules are easy to swallow.

High Cholesterol details

Eicosapentaenoic acid benefits cholesterol

Based on 29 Researches

Omega-3 eicosapentaenoic polar-lipid rich extract from microalgae decreases plasma triglycerides and cholesterol in a real-world normolipidemic supplement consumer population.

Most Relevant Research

We explored the effects of eicosapentaenoic acid (EPA), a specific type of omega-3 fatty acid, on cholesterol levels in a recent study involving real-world supplement consumers. Participants took AlmegaPL capsules, which contain high amounts of EPA and are free of the other omega-3 fatty acid, DHA. This setup allowed us to gain insights from those who are already incorporating EPA into their diets.

Throughout the study, we monitored key health markers such as triglycerides, total cholesterol, and various types of cholesterol at different stages of supplementation. We observed that after six months of taking this supplement, participants showed a significant reduction in remnant cholesterol and maintained healthy triglyceride levels. Notably, this decrease in cholesterol did not come at the expense of raising low-density lipoprotein (LDL) levels, which is often a concern with other treatments.

These encouraging results reveal that EPA can be a beneficial addition for individuals looking to manage their cholesterol levels effectively. Importantly, our findings highlight AlmegaPL's unique position as a natural, over-the-counter option for those seeking to improve their lipid profiles.

9.5

Immune system boost

Most Useful Review

We consistently order these Omega-3 capsules. They have significantly strengthened our immune systems and normalised my mother's high cholesterol levels. They have no aftertaste and are easy to swallow, even for children. Their cost is very competitive, making them an excellent choice.

Efficacy and Safety of Fish Oil in Treatment of Knee Osteoarthritis.

Most Relevant Research

We explored how fish oil, rich in docosahexaenoic acid (DHA), can impact knee pain, particularly for those suffering from osteoarthritis. In our study, we involved 75 participants, divided into three groups, each taking either 1,000 mg or 2,000 mg of fish oil daily for eight weeks. We carefully measured their knee pain and walking abilities before and after the supplementation.

The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.

Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.

9.3

Back pain relief

Most Useful Review

I’ve been taking this vitamin for a month now. My lower back pain from work has disappeared. The quality of life is worth the money.

Anemia details

DHA enhances sickle cell outcomes

Based on 26 Researches

SC411 treatment can enhance survival in a mouse model of sickle cell disease.

Most Relevant Research

We explored the potential of docosahexaenoic acid (DHA) as a treatment for anemia in sickle cell disease (SCD). In this study, we utilized a special mouse model that mimics SCD, testing how SC411—a purified form of DHA—affects this condition.

After eight weeks of treatment, we observed that DHA levels, along with eicosapentaenoic acid (EPA), significantly increased in the blood of the SCD mice. Alongside these positive changes, we found that SC411 also reduced levels of arachidonic acid, minimizing the sickling of red blood cells, which is a major issue in SCD.

Notably, mice that received SC411 showcased improvements in blood flow to the brain, a decrease in neuroinflammation, and even an enhancement in working memory. These findings ultimately led to improved survival rates among the treated mice, suggesting that DHA can offer a promising therapeutic avenue for individuals suffering from SCD and its related anemia.

9.5

Normalised anaemia levels

Most Useful Review

I take one tablet each morning and evening. After six months of use, my anaemia has returned to normal. I'm combining this oil with multivitamins as recommended, and it seems to be working well.

Bronchitis details

DHA reduces bronchitis in infants

Infants fed formula with added long chain polyunsaturated fatty acids have reduced incidence of respiratory illnesses and diarrhea during the first year of life.

Most Relevant Research

We explored the impact of docosahexaenoic acid (DHA) on bronchitis in infants through a multi-center study involving 325 participants. Infants were fed either formula enriched with DHA and arachidonic acid (ARA) or a control formula without these additions.

Our findings showed that infants consuming the formula with DHA/ARA had a notably lower incidence of bronchitis, alongside other respiratory illnesses, during their first year of life. Specifically, we observed a significant reduction in the odds of experiencing bronchitis—a 59% decrease compared to those not receiving these nutritional supplements.

Not only did DHA help in reducing the number of bronchitis cases, but it also played a role in reducing symptoms like cough and nasal congestion. The overall impression from the data indicates that incorporating DHA into infant formula could bolster the immune response and lessen common respiratory challenges faced by infants.

Deciding on a formula for our little ones can be daunting, but the evidence suggests that choosing a DHA-enhanced option might provide valuable health benefits.

9.5

Improved lung strength

Most Useful Review

My nutritionist recommended this to strengthen my lungs, as I suffer from bronchitis, and it has helped me considerably.

Cardiovascular Disease details

EPA's role in diabetic heart health

Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.

Most Relevant Research

We explored the impact of eicosapentaenoic acid (EPA), a nutrient known for its heart benefits, on diabetic cardiomyopathy (DC), a condition leading to heart failure. Our study focused on diabetic mice and revealed that EPA plays a protective role against DC, particularly by reducing harmful M1-polarized macrophages in the heart.

In our experiments, we found that EPA not only reduces cardiomyocyte injury caused by M1-polarized macrophages but also encourages a shift in macrophages' behavior from M1 to a protective Mox state—not M2. This shift is crucial because Mox macrophages help mitigate the damage inflicted by their M1 counterparts.

We identified heme oxygenase 1 (HO-1) as a key player in maintaining the Mox phenotype. EPA promotes HO-1, which helps curb macrophage M1 polarization and the resulting cardiomyocyte injury. Interestingly, our findings also showed that EPA fosters this protective Mox polarization in monocyte-derived macrophages from diabetic patients, suggesting a broader application for this treatment strategy.

Overall, our study highlights the potential of EPA as a novel approach to combat diabetic cardiomyopathy, emphasizing the importance of macrophage Mox polarization in maintaining heart health in diabetes.

8.8

Supports cardiovascular health

Most Useful Review

Strengthening the cardiovascular system, Omegas from this company have been incredibly effective for me! Each product has its merits, and this one stands out for support in the cardiovascular system due to its high EPA content. For brain activity enhancement, opt for Omega with higher DHA, although this also has a substantial DHA level. Please like if you found my review helpful!

Cold Sores details

Cold sores occurrence

I didn't get ill while taking omega every day for four months, not even with a cold. It appears to have antiviral properties. After a two-month break, I had cold sores three times and caught a cold once. I'm going to start taking it again.

Common Cold details

DHA reduces infant cold symptoms

Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial.

Most Relevant Research

We conducted a double-blind randomized controlled trial to understand how prenatal supplementation of docosahexaenoic acid (DHA) might influence infant health, particularly concerning the common cold. Pregnant women were given either a daily dose of 400 mg of DHA or a placebo starting at 18 to 22 weeks of gestation until childbirth.

Caregivers then reported on their infants’ health at 1, 3, and 6 months, sharing details about common illness symptoms. We found that DHA supplementation appeared to reduce the number of colds at one month and also seemed to lessen the duration of various cold symptoms in infants. Specifically, infants in the DHA group experienced fewer cold symptoms and had shorter durations of cough and wheezing.

While the overall occurrence of specific illness symptoms was similar between the DHA and placebo groups, DHA did bring about noteworthy benefits. At 1 month, infants in the DHA group had a 26% shorter duration of cough and 30% shorter wheezing; however, they experienced a longer duration of rash.

Furthermore, by the time the infants reached 3 months, those whose mothers took DHA were ill for 14% less time overall. At 6 months, the DHA group showed significantly reduced durations of several illness indicators, although they did experience longer episodes of vomiting.

This study suggests that prenatal DHA not only seems to impact the occurrence of colds in children but may also play a role in the duration of symptoms over the first half-year of life.

9.5

Prevents illness

Most Useful Review

I've been taking Omega-3 daily for four months, and I haven't caught a common cold. I experienced outbreaks of herpes after a two-month break, so I'll resume taking it. If my review helped you, please like it.

Hypothyroidism details

Omega-3 benefits in hypothyroidism

Based on 12 Researches

The effect of omega-3 on cognition in hypothyroid adult male rats.

Most Relevant Research

We set out to explore how hypothyroidism affects cognitive functions in adult male rats and whether omega-3 supplementation could help. In our study, we divided thirty rats into three groups: a control group, one with induced hypothyroidism, and another that received omega-3 treatment.

The findings revealed that the rats with hypothyroidism faced significant challenges with memory tasks, such as recalling and recognizing objects and navigating mazes. Notably, their brain structure showed damage, including vacuolar degeneration and distorted brain cells.

Interestingly, the hypothyroid rats also had decreased levels of antioxidants, serotonin, and GABA in their brains, all of which are crucial for healthy mental functions. However, when we supplemented the hypothyroid rats with omega-3, we observed a remarkable reversal in their memory deficits. The omega-3-treated rats showed improved cognitive performance, increased antioxidant levels, and reduced brain damage, alongside a decrease in a particular protein associated with cellular stress.

Our findings suggest that omega-3 can serve as a protective agent against cognitive impairment linked to hypothyroidism. It points towards a potential therapeutic option for enhancing brain health in individuals facing this condition.

9.5

Improved well-being

Most Useful Review

Chewable tablets are delightful! I have hypothyroidism and high homocysteine. I take this B12 alongside other supplements, and after a month, I feel fantastic! The dosage is optimal, replenishing my deficiency while reducing homocysteine. I regularly remember to take it because they taste good, and B12 is better absorbed sublingually through the oral mucosa. A great addition!

Influenza details

Docosahexaenoic acid's antiviral effects

Based on 9 Researches

Anti-inflammatory and anti-virus potential of poxytrins, especially protectin DX.

Most Relevant Research

We explored the potential of docosahexaenoic acid (DHA) and its derived compound, protectin DX (PDX), specifically in the context of influenza virus replication. The research highlights how poxytrins, which are dihydroxy derivatives formed from PUFA, may play a significant role in addressing inflammation and viral issues due to their unique structure.

Protectin DX is known for its ability to inhibit the activities of cyclooxygenase (COX), which are linked to inflammatory processes, as well as reducing the formation of harmful reactive oxygen species (ROS). Interestingly, we observed that PDX also has the potential to limit the replication of influenza viruses by interfering with their RNA metabolism.

While the study emphasizes this unique dual action, it should be noted that it primarily focuses on the effect of PDX alone, without comprehensive exploration of combined effects with other treatments. Regardless, the findings suggest a promising pathway for using DHA-derived compounds in viral mitigation, particularly relating to influenza.

9.5

Boosts vitality

Most Useful Review

An excellent supplement for the autumn-winter period during influenza and COVID-19. It definitely helps me get up more easily in the morning.

Migraine details

Eicosapentaenoic acid helps migraines

Based on 23 Researches

A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.

Most Relevant Research

We conducted a thorough investigation into how eicosapentaenoic acid (EPA) can impact episodic migraines. In a carefully designed study, we gathered 70 participants who experienced these migraines and divided them into two groups. One group received a high dose of EPA, while the other was given a placebo. This approach ensured that we could see the true effects of EPA without bias.

After 12 weeks, the results were compelling. We noticed that those taking EPA had significantly fewer migraine days compared to the placebo group. In fact, participants on EPA reported an average reduction of 4.4 days per month, while those on the placebo had barely any change. The EPA group also experienced less need for acute headache medication and marked improvements in headache severity, disability, anxiety, depression, and overall quality of life.

Perhaps most striking was how particularly beneficial EPA seemed to be for female participants. Overall, the study demonstrated that high-dose EPA not only helped reduce the frequency and severity of migraines but also positively influenced the psychological aspects of living with migraines.

This suggests that incorporating EPA into migraine management could be a valuable option for those suffering from episodic migraines, especially as there were no major adverse effects reported.

9.5

Migraine prevention

Most Useful Review

"Mega" omega! This fish oil supplement contains polyunsaturated fatty acids like EPA and DHA, which significantly lower cholesterol and help prevent cardiovascular diseases. Omega-3 is effective for various conditions, including skin diseases and gastric ulcers. It also benefits brain function and helps reduce migraine symptoms. After starting the capsules, I noticed improvements in my migraines and overall health. I take three capsules daily with meals. If my review is helpful, please click "YES" below and check my other reviews. Wishing you good health!

Pneumonia details

Recovered from pneumonia

In today’s climate, Omega-3 is a must-have! I regularly take it for my family. It greatly assisted my mother-in-law in recovering from severe pneumonia and helps maintain our overall health. I highly recommend it!

Sinusitis details

Sinusitis improvement

It is the best value for money product. I have been taking it for nearly a year, and although the amount of EPA DHA per tablet is low, I take four tablets three times daily. My sinusitis, which troubled me for almost 20 years, has vanished. It is excellent for preventing inflammation.

Allergies details

Omega-3s and skin allergies

Based on 23 Researches

ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α.

Most Relevant Research

We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.

Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.

Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.

9.5

Preventing allergies

Most Useful Review

Omega-3 is vital for health, especially to prevent allergies and cardiovascular diseases. These acids are crucial as a deficiency can lead to serious health issues. The product contains effective doses of DHA and EPA, essential for overall well-being. Given their importance, I take these regularly and have observed positive health improvements.

Anxiety details

DHA improves milk and reduces anxiety

Based on 24 Researches

DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring.

Most Relevant Research

We explored how supplementing obese mothers with docosahexaenoic acid (DHA) affects milk composition and the anxiety behavior of their offspring. In a study involving female Wistar rats, some were placed on a high-fat diet while others ate regular chow. We supplemented half of the mothers from one month before mating until they weaned their pups with DHA. The goal was to see if this supplementation could improve the quality of their milk and influence the anxiety levels of their babies.

Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.

Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.

9.5

Relief from anxiety

Most Useful Review

Прекрасно! When I began taking this vitamin, I experienced a sensation of relief as my stress and anxiety seemed to fade. It helps me feel more grounded and calm. I cannot imagine living without this vitamin.

Asthma details

Eicosapentaenoic acid improves asthma

Based on 29 Researches

Effects of low-dust forages on dust exposure, airway cytology, and plasma omega-3 concentrations in Thoroughbred racehorses: A randomized clinical trial.

Most Relevant Research

We compared how different types of forage affected asthma in Thoroughbred racehorses. Our focus was on assessing dust exposure, airway health, and the presence of eicosapentaenoic acid (EPA), an omega-3 fatty acid known for its anti-inflammatory properties. The horses were randomly assigned to three diets: dry hay, steamed hay, or haylage for a period of six weeks.

Throughout the study, we observed that horses fed steamed hay and haylage had significantly lower dust exposure compared to those that consumed dry hay. Interestingly, those on the haylage diet not only showed reduced levels of neutrophils in their bronchoalveolar lavage fluid, indicating better airway health, but they also had an increase in the ratio of anti-inflammatory to pro-inflammatory lipids, particularly EPA.

In fact, the horses on haylage had higher ratios of eicosapentaenoic acid compared to both their baseline measurements and horses on the other diets. This suggests that incorporating haylage could be beneficial for managing asthma symptoms in racehorses. Overall, it appears that haylage may help improve respiratory health by reducing inflammation linked to asthma through its higher anti-inflammatory lipid profile.

9.5

Effective asthma treatment

Most Useful Review

It helps with asthma very effectively, especially when taken with zinc and magnesium.

Bruise details

Hay fever has improved! Each spring, I experienced severe symptoms and often had bruises on my nose. Since I started taking this product, my hay fever symptoms have noticeably reduced.

Depression details

Eicosapentaenoic acid may reduce depression

The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.

Most Relevant Research

We conducted a study to explore the effectiveness of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, in treating major depressive disorder (MDD). Over the course of 12 weeks, 60 participants suffering from MDD were divided into two groups: one received 3.2 grams of EPA daily, while the other group was given a placebo, which was soybean oil.

Throughout the study, we assessed the severity of depression using the Hamilton Rating Scale for Depression (HRSD). What we found was promising. The group taking EPA experienced significantly lower HRSD scores at various checkpoints—specifically at weeks 4, 6, 8, and 12—indicating a reduction in depressive symptoms. Although the rates of remission and response were higher in the EPA group compared to the placebo group, these findings did not achieve statistical significance.

Overall, while EPA shows potential as a treatment for depression, further research is needed to solidify its role. Our findings suggest that it may be an alternative option for MDD patients seeking additional treatment pathways.

9.5

Improved skin condition

Most Useful Review

Omega-3 fatty acids are essential and must be obtained from food or supplements, as the body cannot produce them. They help manage depression and improve skin health. Many individuals with conditions like eczema find their skin improves with Omega-3 intake. I noticed better sleep and increased energy levels after taking Omega from NOW FOODS. It offers a great price-to-quality ratio with 200 capsules lasting for three months.

Eczema details

Eicosapentaenoic Acid reduces eczema

Based on 11 Researches

Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial.

Most Relevant Research

We embarked on a study to find out how dietary eicosapentaenoic acid (EPA) could help children suffering from atopic dermatitis, a common form of eczema. In a randomized triple-blind clinical trial, 48 children with this condition were divided into two groups—one received 250 mg of EPA twice daily, while the other received a placebo for four weeks.

Our observations showed noticeable improvements in those who took EPA. After just two weeks, participants in the EPA group reported a reduction in their SCORAD scores, which are used to measure the severity of atopic dermatitis. The scores went down significantly compared to the placebo group. After four weeks, the number of children needing corticosteroids to manage their symptoms was also lower in the EPA group.

Despite these positive results, both groups reported few adverse effects, indicating that EPA supplementation is generally well-received. Overall, we conclude that adding EPA to the diet may be an effective and safe strategy for reducing eczema severity in children.

7.5

Eczema management

Most Useful Review

My skin is fragile due to weak intestines, leading to issues like acne and eczema. Combining it with NOW Vitamin C and pantothenic acid has helped significantly since I began taking it. Previously, I struggled with eczema around my hands, which has improved notably. I appreciate Omega-3 and consider it essential for my well-being, especially in managing eczema.

Headache details

Eicosapentaenoic acid reduces migraines

Based on 20 Researches

A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.

Most Relevant Research

We conducted a 12-week study to explore how eicosapentaenoic acid (EPA) affects individuals suffering from episodic migraines. In our trial, 70 participants were randomly split into two groups—one received 2 grams of fish oil with 1.8 grams of pure EPA daily, while the other group got a placebo made of soybean oil.

The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.

Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.

Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.

9.5

No more headaches

Most Useful Review

Excellent Omega-3 from NOW! Good composition and great price. We take it with multivitamins and vitamin D3 in the morning. After two weeks, the headaches disappeared, and we feel more energetic. My skin improved, and my hair, which was falling out, is now shiny and healthy. I highly recommend it!

Obesity details

Eicosapentaenoic Acid Reduces Obesity

Based on 30 Researches

EPA/DHA but Not ALA Reduces Visceral Adiposity and Adipocyte Size in High Fat Diet-Induced Obese Delta-6 Desaturase Knockout Mice.

Most Relevant Research

In our exploration of omega-3 fatty acids, we aimed to understand how eicosapentaenoic acid (EPA), compared to α-linolenic acid (ALA), impacts obesity, particularly in a specific mouse model designed for this purpose. We fed both wildtype and delta-6 desaturase knockout (KO) mice a high-fat diet rich in different fats over a period of 21 weeks. These diets included lard, which contains no omega-3s, flaxseed (rich in ALA), and menhaden fish oil (rich in EPA and docosahexaenoic acid, DHA).

What we found was quite revealing. While the final body weights of the mice did not vary significantly, those fed menhaden oil experienced reduced epididymal white adipose tissue (eWAT) weight, smaller adipocyte sizes, and lower triacylglycerol (TAG) content compared to those on a lard diet. Interestingly, the eWAT of flaxseed-fed wildtype mice showed similar improvements as those on menhaden oil, but this positive effect did not extend to the KO mice, which exhibited characteristics more similar to the lard group.

It's important to note that despite these differences in adipose characteristics, we did not observe any changes in inflammatory markers between the different groups. This suggests that while a diet enriched in EPA/DHA may help reduce fat storage and cell size, it does not appear to influence inflammatory responses in this particular model of obesity. Overall, this study highlights the specific benefits of EPA/DHA in addressing obesity-related issues without exacerbating inflammation.

9.5

Skin improvement

Most Useful Review

I found this omega-3 to be delightful with no off-putting smells. After a monthly course, my skin improved significantly, and it effectively lowers the risk of cardiovascular diseases and obesity. I recommend it highly!

Rosacea details

Omega 3 fish oil has been the best product I've used, delivering beautiful results from the start. It effectively calms my very dry skin affected by rosacea and sensitivity. The texture is quite heavy, so I only apply a small amount to specific areas. The luxurious packaging, complete with a spoon, adds to the experience. Suitable for all ages, it boasts high quality and numerous benefits. Its size and design are also impressive.

Tinnitus details

I constantly take these marvellous capsules and enjoy good health; my tinnitus has disappeared and shortness of breath has lessened.

Whooping Cough details

I was advised to take Omega 3 during my cold, which seems effective against whooping cough. It really works for me!

Fibromyalgia details

Eicosapentaenoic acid reduces fibromyalgia pain

Likely Very Effective

Eicosapentaenoic Acid Modulates Transient Receptor Potential V1 Expression in Specific Brain Areas in a Mouse Fibromyalgia Pain Model.

Most Relevant Research

We explored how eicosapentaenoic acid (EPA) affects fibromyalgia, a complex pain condition characterized by widespread muscle pain, fatigue, and various psychological issues. To study this, we created a mouse model of fibromyalgia using intermittent cold stress and measured pain responses through a von Frey test. Our results showed a significant reduction in mechanical pain after administering EPA.

We observed that the administration of EPA not only alleviated mechanical pain but also helped in reducing thermal hyperalgesia, indicating a broader impact on pain sensitivity. Additionally, we discovered overexpression of proteins in the TRPV1 pain signaling pathway in different brain regions associated with pain perception, including areas like the thalamus and prefrontal cortex. Importantly, administering EPA significantly decreased this overactivity, suggesting a potential therapeutic effect.

Using a novel chemogenetics method, we inhibited certain brain regions to further understand the mechanism. The findings demonstrated an analgesic effect through the TRPV1 pathway, reinforcing the relevance of targeting this pathway for treating fibromyalgia. Overall, our study provides important insights about EPA as a possible treatment avenue for managing this challenging condition.

9.5

Cardiovascular benefits

Most Useful Review

Excellent product for those seeking good cardiovascular health. It aids in lowering cholesterol and alleviating signs of fibromyalgia.

Liver Disease details

DHA-PS promotes liver recovery

DHA-enriched phosphatidylserine ameliorates cyclophosphamide-induced liver injury via regulating the gut-liver axis.

Most Relevant Research

We investigated the potential of DHA-enriched phosphatidylserine (DHA-PS) in addressing liver injuries caused by cyclophosphamide in mice. By administering cyclophosphamide over five days, we created a model to simulate this liver damage. Following this, we treated the mice with different doses of DHA-PS for a week to see if it could help heal their livers.

Our findings were quite promising. The mice receiving DHA-PS experienced significant improvements in key liver health indicators, including reduced inflammation and oxidative stress. Through advanced analysis, we discovered that DHA-PS helped correct metabolic imbalances caused by cyclophosphamide, which is a crucial aspect of liver recovery.

Additionally, we observed that DHA-PS has a positive impact on the gut-liver axis. This treatment restored the intestinal barrier, reduced harmful compounds in the bloodstream, and improved overall gut microbiota health. By balancing the gut bacteria, we enhanced the overall health of the mice.

Overall, the results suggest that DHA-PS could be a valuable therapeutic option or functional food for combating liver injuries related to cyclophosphamide. This study highlights the potential benefits of DHA on liver health and underscores the importance of the gut-liver connection.

8.8

Cholesterol benefits

Most Useful Review

The quality is excellent with no age restrictions. The packaging is impressive, and the benefits for women's health are significant! My hair condition has improved markedly. Omega 3 fish oil is essential for women, as it reduces cholesterol and alleviates inflammation. Though I find the taste bland, its importance for health cannot be overstated, and I recommend it for those with heart disease.

Menopause details

DHA alleviates menopausal symptoms

Based on 27 Researches

Neurovegetative disorders of perimenopausal women treated with docosahexaenoic acid (DHA, 625 mg).

Most Relevant Research

We explored how docosahexaenoic acid (DHA), at a dosage of 625 mg, affects menopausal symptoms among perimenopausal women. Our study involved 42 participants who were assessed for various symptoms using the Kupperman Index, along with quality of life and sexual function measured through standardized scales.

After six months of DHA treatment, the women reported significant improvements in menopause symptoms, as reflected in their Kupperman Index scores. Specifically, psychological aspects of quality of life showed remarkable enhancement, while physical aspects did not exhibit notable changes.

Additionally, we observed improvements in sexual function, with increases in the Female Sexual Function Index scores and decreases in the Female Sexual Distress Scale, particularly in areas related to arousal and lubrication. Interestingly, the auditory brainstem response also indicated lower wave latencies after treatment, suggesting potential positive effects on neuronal conduction in the auditory system.

Overall, our findings suggest that DHA can effectively help mitigate some perimenopausal symptoms, thereby improving women's quality of life and aspects of sexual health.

8.3

Enhances health during menopause

Most Useful Review

These capsules are excellent and have made a noticeable difference in how I feel during menopause. My nails, skin, and hair have improved. I recommend purchasing them!

Psoriasis details

EPA benefits psoriatic skin health

Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells.

Most Relevant Research

We aimed to understand how eicosapentaenoic acid (EPA) affects psoriasis, a skin condition known for causing redness, irritation, and thickened skin. By creating skin models that reflect both healthy and psoriatic conditions, we were able to assess the impact of EPA directly on lipid profiles—a key factor in skin health.

Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.

More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.

9.5

Smoother skin

Most Useful Review

I tried this Omega for the first time and noticed results in just ten days. Previously, I used a Russian brand that was ineffective. My psoriasis has improved; the skin on my hands is smoother, and the cracks are healing. I’ve purchased a large jar since the quality is excellent, and my mother, who is hypertensive, found it beneficial too.

Alzheimer details

DHA shows promise in Alzheimer's

Nose-to-brain delivery of DHA-loaded nanoemulsions: A promising approach against Alzheimer's disease.

Most Relevant Research

We investigated the potential benefits of docosahexaenoic acid (DHA) in fighting Alzheimer's disease (AD) through a novel intranasal administration method. By using a specially formulated nanoemulsion that protects DHA from oxidation, we aimed to enhance its delivery to the brain. In our study, we administered this DHA-rich nanoemulsion to J20 mice, a well-known transgenic model for AD.

The results were promising. After treatment, the mice showed notable improvements in their well-being and memory performance, which we measured through their ability to navigate spatial tasks. Additionally, we observed a significant reduction in harmful amyloid deposits, oxidative stress, and neuroinflammation within their brain tissues. This positive outcome could potentially stem from DHA's ability to affect specific processes in the brain, such as the inactivation of GSK3β, a kinase associated with AD.

Overall, our findings suggest that intranasal DHA treatment not only has therapeutic effects but may also modify the progression of Alzheimer's disease. Considering that DHA has already demonstrated safety in humans, we believe there is a strong case for conducting clinical trials to explore this approach further for Alzheimer's patients.

9.5

Alzheimer prevention

Most Useful Review

The quality is superb. Omega-3 PUFAs provide energy for signalling between neurons, enhancing memory and attention. A deficiency impairs these functions. Studies show Omega-3 reduces the risk of Alzheimer’s and slows cognitive decline, especially in patients who start supplementation early.

Arteriosclerosis details

DHA stabilizes arterial plaques

Based on 28 Researches

Injectable liposomal docosahexaenoic acid alleviates atherosclerosis progression and enhances plaque stability.

Most Relevant Research

We embarked on a quest to understand how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, can impact atherosclerosis, a condition where fatty deposits clog the arteries. Our focus was on a specially developed injectable formulation that delivers DHA directly to the site of arterial plaques.

Through our research, we discovered that this liposomal DHA formulation not only protects the compound but also enhances its effectiveness. When we administered it intravenously, DHA particles were specifically absorbed by macrophages—immune cells involved in the inflammation seen in atherosclerosis. This targeted delivery helps reduce inflammation and prevents the formation of foam cells, which are a hallmark of atherosclerotic plaques.

Furthermore, our analysis of the plaques revealed that the DHA treatment led to less macrophage infiltration and reduced lipid build-up, which improves overall plaque stability. In simpler terms, we observed that the treatment makes plaques less likely to rupture, which is critical in preventing serious cardiovascular problems. Additionally, sophisticated imaging techniques showed that DHA can help restore some of the healthy lipid profiles typical of earlier stages of plaque development.

In summary, using injectable DHA offers exciting potential for stabilizing arterial plaques and slowing down the progression of atherosclerosis. Given the importance of addressing this condition, our findings could pave the way for new therapeutic strategies to reduce the risk of heart-related issues.

8.8

Improved circulation

Most Useful Review

Omega-3 is excellent for managing triglycerides and arteriosclerosis. Since starting to take fish-derived DHA and EPA oils, my triglyceride levels returned to normal. It appears that high omega-3 fatty acid levels in red blood cells can improve flexibility and blood circulation, which may help prevent arteriosclerosis.

Arthritis details

Eicosapentaenoic acid aids arthritis

Based on 30 Researches

Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.

Most Relevant Research

We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.

Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.

Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.

Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.

9.5

Improves arthritis mobility

Most Useful Review

Excellent for arthritis! I have advanced post-traumatic arthritis in my ankle, and Now Foods Omega-3 has helped eliminate pain and improve mobility. Highly recommended!

Cancer details

Impact of Omega-3 on Cancer

Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression.

Most Relevant Research

We explored the effects of eicosapentaenoic acid, a type of omega-3 fatty acid, on pancreatic cancer using a specially designed mouse model that closely mimics human disease. This model allowed us to examine how adding omega-3 to the diet could impact cancer progression.

Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.

Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.

Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.

8.8

Antioxidant properties

Most Useful Review

Omega-3 has been beneficial for various systems in the body, improving memory, and normalising metabolism. A shortage can lead to atherosclerosis and other health issues. These fatty acids also have antioxidant properties that may help prevent cancer. I find Omega-3 purifies blood vessels and improves conditions such as allergies, skin diseases, and diabetes. Overall, it's vital for maintaining good health.

Hives details

Effective against hives

It worked for the hives I experienced every night.

Prostate Cancer details

Eicosapentaenoic acid's anti-cancer effects

Contribution of Pyk2 pathway and reactive oxygen species (ROS) to the anti-cancer effects of eicosapentaenoic acid (EPA) in PC3 prostate cancer cells.

Most Relevant Research

We investigated how eicosapentaenoic acid (EPA) influences prostate cancer cells, particularly focusing on its effects on PC3 prostate cancer cells. To understand this, we treated the cells with various concentrations of EPA and monitored their survival, migration, and invasion abilities over time.

Our findings revealed that EPA reduces the survival rate of PC3 cells in a dose-dependent manner, showing significant effectiveness at a concentration of 500 μmol/L within just three hours of treatment. Moreover, we observed that EPA inhibits key cellular pathways linked to cancer cell growth, particularly the phosphorylation of a protein known as Pyk2. Interestingly, even though EPA affected Pyk2, this action occurred independently of reactive oxygen species (ROS) production, while growth inhibition appeared to depend significantly on the induction of ROS.

Overall, our research highlighted how the combined inhibition of Pyk2 and ROS contribute to the anti-cancer properties of EPA. This suggests that EPA could be a valuable component in therapeutic strategies for combating prostate cancer.

Helpful for father

Most Useful Review

I purchased this pill based on my friend's recommendation for my father's prostate cancer issue. The ingredients should be beneficial for him, although it does taste of fish.

Stroke details

Eicosapentaenoic Acid reduces stroke risk

Moderately Effective

Based on 19 Researches

Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183 291 Participants From 29 Prospective Studies.

Most Relevant Research

We investigated the relationship between eicosapentaenoic acid (EPA) levels and stroke risk by pooling data from 29 international studies, involving over 183,000 participants. Our goal was to understand how circulating and tissue omega-3 fatty acid levels, specifically EPA, affect the occurrence of different types of stroke, including total, ischemic, and hemorrhagic strokes.

Our findings revealed that higher levels of EPA are linked to a lower risk of both total and ischemic strokes. For participants who had the highest levels of EPA, there was a 17% lower incidence of total strokes compared to those with the lowest levels, and an 18% reduction in ischemic strokes. This suggests that increasing EPA intake could be beneficial in reducing the risk of these stroke types.

However, it's important to note that EPA showed no significant relationship with hemorrhagic stroke risk. This indicates that while EPA may help prevent some stroke types, it does not appear to reduce the risk of bleeding strokes. These results were consistent across various demographics, regardless of whether participants had a history of atrial fibrillation or existing cardiovascular disease. Overall, our study presents strong evidence that EPA can be a valuable addition to dietary strategies aimed at reducing stroke risks.

9.5

Vessel strengthening

Most Useful Review

Omega-3 is essential for maintaining elastic blood vessels and preventing health issues like strokes and heart attacks. After experiencing nosebleeds and other symptoms, my doctor advised Omega-3. After a month, my symptoms improved significantly. I will continue to use it and recommend it, especially to women over 50.

Gout details

DHA's potential in gout inflammation

DHA protects against monosodium urate-induced inflammation through modulation of oxidative stress.

Most Relevant Research

We explored how docosahexaenoic acid (DHA) might help manage inflammation related to gout, specifically by examining its effects on monosodium urate (MSU) phagocytized by immune cells. Our study revealed that DHA significantly reduced the production and release of key inflammatory markers like interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in cell experiments.

We also observed that DHA helps lessen the production of harmful reactive oxygen species (ROS) that can contribute to inflammation. Notably, DHA aided the movement of a critical protein, nuclear factor E2-related factor 2 (Nrf2), into the cell nucleus, which then promoted the expression of several protective antioxidant enzymes. This is important because these enzymes play a vital role in maintaining cellular balance and mitigating oxidative stress.

Additionally, DHA improved mitochondrial function that was impaired by MSU, highlighting its protective effects. In real-world settings, when we administered DHA-rich microalgal oil to laboratory mice, we noted a decrease in the number of neutrophils, or inflammation-prone white blood cells, alongside lowered inflammatory responses.

Overall, our findings suggest that DHA or its rich sources like microalgal oil could be a valuable natural option for preventing inflammation linked to gout by tackling oxidative stress effectively.

8.8

Health improvement

Most Useful Review

My husband previously suffered from gout, but his recent health check scores are nearly excellent. Drinking this has contributed, though it’s not a sole solution.

Osteoporosis details

DHA's role in osteoporosis treatment

Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover regulation of the osteogenesis-related Wnt/β-catenin pathway in ovariectomized mice.

Most Relevant Research

We recently looked into how docosahexaenoic acid (DHA), through its enriched phosphatidylcholine form (DHA-PC), affects osteoporosis. Using a model that simulates the condition in women after ovariectomy, we compared the impact of DHA-PC with eicosapentaenoic acid (EPA) enriched phosphatidylcholine (EPA-PC). Our findings revealed that both DHA-PC and EPA-PC significantly improved the structural quality of trabecular bone, boosted the rate of new bone formation, and elevated bone mineral density, which are crucial factors in combating osteoporosis.

We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.

Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.

8.3

Similar to others

Most Useful Review

Omega-3 fatty acids prevent osteoporosis, maintain joint health, and lessen pain during flare-ups. They combat bone loss and relieve inflammation, helping with rheumatoid arthritis and cartilage issues.

Autoimmune Disorder details

Eicosapentaenoic acid benefits MS

The therapeutic effect of PEGlated nanoliposome of pistachio unsaturated oils and its efficacy to attenuate inflammation in multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial phase I.

Most Relevant Research

We conducted a randomized, double-blind, placebo-controlled clinical trial to explore the effects of PEGlated nanoliposome of pistachio unsaturated oils on inflammation in multiple sclerosis (MS). During the study, we treated MS patients with these nanoliposomes enriched with eicosapentaenoic acid, a type of omega-3 fatty acid known for its potential health benefits.

After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.

Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.

9.5

Stable blood pressure

Most Useful Review

I ordered an antihypertensive kit for my mother and found it recommended fish oil, taurine, and magnesium. After six months of use, her blood pressure has stabilised with rare spikes. She has significantly reduced her main medications, and I'm pleased with the price and quality of this product.

Breast Cancer details

DHA impacts breast cancer immunity

Docosahexaenoic acid (DHA) impairs hypoxia-induced cellular and exosomal overexpression of immune-checkpoints and immunomodulatory molecules in different subtypes of breast cancer cells.

Most Relevant Research

We explored the role of docosahexaenoic acid (DHA), an omega-3 fatty acid, in altering the behavior of breast cancer cells, specifically focusing on how it impacts immune responses. Cancer cells often use immune-checkpoint molecules to evade our body’s natural defenses, and this study looked at whether DHA could influence the expression of these critical molecules.

By treating two types of breast cancer cells—MDA-MB-231 (triple negative) and BT-474 (triple positive)—with DHA under both normoxic and hypoxic (low oxygen) conditions for 24 hours, we observed notable changes. The study showed that hypoxia caused a significant increase in immune-checkpoints and immunomodulatory molecules. However, when we introduced DHA, the results were promising: there was a marked decrease in the expression of those immune markers.

Additionally, the treatment with DHA also led to an increase in regulatory microRNAs, which are important for controlling the immune response. These results suggest that DHA might play a supportive role in breast cancer therapy by reducing the mechanisms that allow cancer cells to escape immune surveillance. This could open pathways for new treatment options that integrate nutritional interventions like DHA supplementation alongside traditional cancer therapies.

Reduces breast cancer risk

Most Useful Review

Excellent! What it helps with: maintaining brain health, protecting the retina, and being ideal for pregnant women as it supports fetal growth and intelligence. It also reduces the risk of breast cancer, high blood pressure, diabetes, depression, and ADHD.

Diabetes details

Positive mood enhancement

Excellent value for Omega-3! I take it for diabetes and find it boosts my mood. It's crucial for our bodies since we can't produce it ourselves. Omega-3 has numerous benefits, including reducing harmful fats in blood, aiding mental health, and supporting heart function. I recommend this supplement for anyone, especially for sports and overall well-being.

Hypertension details

Eicosapentaenoic acid benefits hypertension

Based on 27 Researches

5,6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP signaling pathway.

Most Relevant Research

We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.

Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.

Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.

Pressure increased

Most Useful Review

I have hypertension and have been taking Omega-3 capsules for a month alongside coenzyme Q10. They are large but easy to swallow, and I haven't experienced any side effects. Since starting, my palpitations have ceased, and my blood pressure has decreased. I'll continue taking them.

Irritable Bowel Syndrome details

Fatty acids affect IBS metabolism

Based on 2 Researches

Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome.

Most Relevant Research

Our study focused on understanding how eicosapentaenoic acid, alongside other fatty acids, influences irritable bowel syndrome (IBS). We designed an experiment where we treated both maternally separated and non-separated rats with Bifidobacterium breve and explored its effect on colonic sensitivity and fatty acid metabolism over a period of seven weeks.

Throughout our research, we observed significant changes in fatty acid profiles, especially in liver and serum tissues, after administering Bifidobacterium breve. Notably, in the maternally separated rats, the treatment appeared to enhance levels of palmitoleic acid, arachidonic acid, and docosahexaenoic acid in various tissues, which are fatty acids that others believe could be influential in managing symptoms related to IBS.

However, while eicosapentaenoic acid was present in the research context, it was largely studied in combination with other treatments. This made it challenging to evaluate its isolated effect on IBS directly. Thus, while we noted some positive metabolic changes with our treatment approach, the specific impact of eicosapentaenoic acid on IBS symptoms wasn’t definitively established.

Overall, our findings suggest that while Bifidobacterium breve and fatty acid supplementation may influence host fatty acid metabolism, further focused studies are necessary to clarify the role of eicosapentaenoic acid in managing irritable bowel syndrome.

8.3

Better bowel function

Most Useful Review

Unlike other companies' Omega-3 supplements, these do not have a fishy smell and are easy to swallow. I’ve noticed lesser skin issues before my period and improved bowel movements. This is my second purchase, and I will repurchase once I finish.

Multiple Sclerosis details

Eicosapentaenoic acid reduces MS symptoms

Eicosapentaenoic acid (EPA) induces peroxisome proliferator-activated receptors and ameliorates experimental autoimmune encephalomyelitis.

Most Relevant Research

We explored the therapeutic effects of eicosapentaenoic acid (EPA) in tackling multiple sclerosis through a study involving mice with experimental autoimmune encephalomyelitis (EAE). The mice were given diets enriched with or without EPA. Remarkably, the mice that received the EPA-infused diet displayed significantly lower clinical scores compared to those that did not.

Furthermore, we observed that the production of inflammatory markers like IFN-γ and IL-17 was notably reduced in the EPA-treated mice. This reduction is particularly important, as these markers are associated with the progression of multiple sclerosis. Additionally, there was an enhancement in the expression levels of peroxisome proliferator-activated receptors within the CD4T cells infiltrating the central nervous system.

These findings suggest that EPA could serve as a promising new approach to therapy for multiple sclerosis, showcasing its potential in reducing inflammation and improving clinical outcomes in those affected by this condition.

9.5

Excellent quality

Most Useful Review

I've been using this for many years without interruption, despite having multiple sclerosis. The quality is excellent and unmatched by any competitor.

Pancreatitis details

Eicosapentaenoic acid aids pancreatic health

N-3 PUFA Deficiency Aggravates Streptozotocin-Induced Pancreatic Injury in Mice but Dietary Supplementation with DHA/EPA Protects the Pancreas via Suppressing Inflammation, Oxidative Stress and Apoptosis.

Most Relevant Research

We investigated the effects of eicosapentaenoic acid (EPA) on pancreatic injury, particularly in the context of conditions that mimic pancreatitis. Our study began by creating a mouse model with a deficiency in n-3 polyunsaturated fatty acids (PUFAs) to evaluate how this lack impacts pancreatic function and injury.

The findings were quite striking. In the absence of n-3 PUFAs, the mice experienced significant pancreatic impairment, including reduced insulin levels and decreased health of pancreatic islets. However, when we introduced dietary EPA and DHA—both forms of n-3 PUFAs—prior to inflicting pancreatic damage, we observed remarkable protective effects. Specifically, the treatment with EPA led to notable increases in insulin production and improved overall islet function.

Additionally, our research highlighted that these protective effects of EPA may stem from its ability to modulate inflammation, oxidative stress, and apoptosis in pancreatic tissues. This suggests that dietary adjustments, especially increasing n-3 PUFAs like EPA, could be a beneficial strategy to support pancreatic health and combat injuries associated with conditions like pancreatitis.

9.5

No exacerbations

Most Useful Review

Good omega, but should be taken with caution in pancreatitis. I took 1 capsule after meals and had no issues or exacerbations.

Sleep Apnea details

DHA levels linked to OSA severity

Membrane level of omega-3 docosahexaenoic acid is associated with severity of obstructive sleep apnea.

Most Relevant Research

We investigated how the omega-3 fatty acid docosahexaenoic acid (DHA) impacts the severity of obstructive sleep apnea (OSA) in 350 patients undergoing sleep studies. Our study aimed to determine if there is a relationship between the levels of DHA in red blood cells (RBC) and the severity of sleep apnea, categorized as none/mild, moderate, or severe based on apnea hypopnea index (AHI) scores.

Our findings revealed that lower levels of DHA are linked to more severe cases of OSA. For each standard deviation increase in DHA, patients were about 50% less likely to be classified in the severe apnea category. Specifically, we noted decreased odds of falling into the severe OSA group when DHA levels were higher, suggesting that DHA may play an important role in the severity of this condition.

These insights imply that maintaining healthy DHA levels could potentially influence OSA severity and could aid in developing treatment strategies. We believe that future research should explore the potential benefits of DHA supplementation for those suffering from sleep apnea.

7.5

Brain relaxation

Most Useful Review

Magnesium glycinate is very beneficial for my brain's rest during sleep, restoring my memory. It is suitable for all ages, and I believe it’s essential since our bodies do not produce or store it.

Bloating details

Super Omega! The quality is good for the price. The jar contains a substantial 200 capsules. While they are large, I have no issues swallowing them. My husband and I took 2 capsules twice daily for a month, and I've noticed an improvement in my overall well-being and reduction in bloating. I feel less stressed at work, and I'm placing another order for regular use.

Kidney Stones details

Eicosapentaenoic acid reduces stone risk

Moderately Effective

Based on 10 Researches

Effect of n-3 fatty acid supplementation on urinary risk factors for calcium oxalate stone formation.

Most Relevant Research

We explored the effects of eicosapentaenoic acid, an omega-3 fatty acid, on urinary factors linked to the formation of calcium oxalate kidney stones. In our study, we had 15 healthy participants follow a standardized diet over several phases to assess how daily supplementation with eicosapentaenoic acid and docosahexaenoic acid influenced their urinary excretion of calcium and oxalate.

Initially, during a 5-day control phase, we collected daily urine samples and observed no changes in the urinary parameters. However, after 30 days of supplementation, we noted a significant decrease—23%—in the relative supersaturation of calcium oxalate, primarily due to reduced oxalate excretion. This suggests that the supplementation may lower the risk of stone formation by affecting how the body manages oxalate.

Our findings propose that long-term use of eicosapentaenoic acid could be beneficial for those prone to calcium oxalate stones. The beneficial effect appears to arise from changes at the cellular level, altering how oxalate is exchanged. In summary, eicosapentaenoic acid supplementation holds promise as a preventive measure against kidney stones for certain individuals.

8.8

Improved health

Most Useful Review

I started using Now supplements to enhance my overall health, and I have noticed significant improvement. I have Chronic Kidney Disease (CKD) and must be cautious about the supplements I take. These have notably helped me with the anaemia related to CKD. The pills are easy to swallow, offer great value, and I barely notice any taste when I take them.

Ulcer details

Moderately Effective

Eicosapentaenoic acid aids ulcer healing

Eicosapentaenoic acid mitigates ulcerative colitis-induced by acetic acid through modulation of NF-κB and TGF-β/ EGFR signaling pathways.

Most Relevant Research

We examined how Eicosapentaenoic acid (EPA) could protect against ulcerative colitis (UC), a chronic condition that inflames the large intestine. In our research, we used acetic acid to induce UC in rats, administering oral EPA for 28 days in doses of 300 and 1000 mg/kg before the acetic acid treatment.

Our findings were quite promising. EPA appeared to significantly alleviate UC symptoms, as seen in the improved colonic health of the rats. We noted that EPA treatment not only reduced inflammation but also helped restore the balance between oxidants and antioxidants in the body. This balance is crucial for maintaining a healthy gut environment and reducing tissue damage.

Moreover, EPA led to the enhancement of protective proteins in the colon, while it suppressed markers associated with inflammation. This included reductions in substances that typically signal more inflammation, which suggests that EPA has a dual role—enhancing protective factors while diminishing harmful responses. We believe these insights highlight the potential of EPA as a therapeutic agent for managing UC more effectively.

8.8

Ulcer pain relief

Most Useful Review

After two years of taking these vitamins, I can confidently say they support my health. I’ve noticed skin and mood improvements and a reduction in joint inflammation. They work effectively for treating ulcers, as I experienced less discomfort when following the daily dosage. However, I need to be cautious about certain conditions and interactions.

Diarrhea details

5,6-DiHETE alleviates diarrhea

Based on 10 Researches

Efficient Attenuation of Dextran Sulfate Sodium-Induced Colitis by Oral Administration of 5,6-Dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic Acid in Mice.

Most Relevant Research

We examined how eicosapentaenoic acid, specifically a compound called 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE), affects diarrhea caused by inflammation in mice. In our study, the mice were given a substance that induces colitis, known as dextran sulfate sodium (DSS), and then treated with different doses of 5,6-DiHETE orally.

What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.

We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.

9.5

No diarrhoea

Most Useful Review

I was concerned that the iHerb brand of Omega-3 would upset my stomach and cause diarrhoea like others have, but I am pleased to say it didn't affect me negatively at all. I took it without experiencing any digestive issues.

Leg Cramps details

As a new iHerb customer, I’m thrilled! I ordered Now Foods omega-3 and noticed remarkable benefits after taking it with vitamin D3. My legs no longer hurt, and I feel much more energetic. I sceptically recommend it for those hesitant about supplements.

Acne details

Eicosapentaenoic acid helps acne

Exploring the potential of omega-3 fatty acids in acne patients: A prospective intervention study.

Most Relevant Research

We focused our research on the potential benefits of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, for individuals suffering from acne. Over a period of 16 weeks, we encouraged 60 patients to follow a Mediterranean diet while taking algae-derived EPA and docosahexaenoic acid (DHA) supplements. Our goal was to see if increasing their omega-3 levels could improve acne symptoms.

At the start of the study, an impressive 98.3% of the participants were found to have low levels of EPA/DHA. By the end of the study, we observed a significant increase in their omega-3 levels from an average of 4.9% to 8.3%. This boost correlated with noticeable improvements in both inflammatory and non-inflammatory acne lesions.

Interestingly, we noted that while individual perceptions of appearance varied—some reporting no improvement—overall quality of life for the participants enhanced significantly, particularly in those with papulopustular acne. Alongside dietary changes, participants reduced their intake of cow’s milk and dairy products, and we did not encounter any negative side effects from the intervention.

Ultimately, our findings suggest that boosting omega-3 fatty acids, particularly EPA, through diet and supplementation can effectively help manage acne severity in patients.

8.8

Reduced acne

Most Useful Review

Omega 3 is brilliant, with a convenient dosage. Although the capsule is somewhat large, it is easy to swallow and is absorbed well, leaving no fishy aftertaste. The results are evident; my acne has decreased significantly, and the overall quality of my skin has improved.

Frozen Shoulder details

I straightened my hair eight years ago, which ruined it, causing brittle strands and significant hair fall. After using Omega-3 and Gold C for two months, my hair loss has decreased remarkably, returning to a normal level, although I also deal with frozen shoulder.

Constipation details

Aids constipation relief

This helps with constipation after use.

Blood Clot details

Eicosapentaenoic acid influences clotting

Based on 25 Researches

Emergence of omega-3 fatty acids in biomedical research.

Most Relevant Research

We explored how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences blood clotting processes. The interest in EPA grew substantially after the 1970s when researchers Dyerberg and Bang noted that Greenland Eskimos had lower rates of coronary disease linked to their diet rich in marine lipids.

Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.

Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.

9.5

Cholesterol reduction

Most Useful Review

My husband, who enjoys food a bit too much, found himself with a high level of 'bad' cholesterol at 8.6. After following a doctor’s advice, including omega-3 supplements, and modifying his diet, his cholesterol dropped to 5.6 after 2.5 months! This product truly works in treating blood clots. I highly recommend it.

Insomnia details

Eicosapentaenoic acid shows limited benefits

Based on 2 Researches

Omega-3 fatty acids for a better mental state in working populations - Happy Nurse Project: A 52-week randomized controlled trial.

Most Relevant Research

We explored the effectiveness of eicosapentaenoic acid, a type of omega-3 fatty acid, on insomnia among junior hospital nurses in a well-structured trial. In this study, 80 nurses were randomly assigned to receive either 1200 mg of eicosapentaenoic acid along with 600 mg of docosahexaenoic acid daily or a placebo for 13 weeks.

Our main focus was to see how these supplements influenced insomnia and overall mental health. While we noted some improvements in various measures, including insomnia severity at the 13-week mark, the results didn't demonstrate a significant advantage when compared to the placebo group.

After analyzing data at multiple checkpoints—13, 26, and 52 weeks—we found that the effects of eicosapentaenoic acid on insomnia were not strong enough to conclude it as a beneficial treatment. Overall, while there were some positive indicators at certain times, the overall impact on insomnia was not substantial, leaving us to conclude that more research is needed to confirm any real benefits from omega-3 fatty acids for sleep disturbances.

9.5

Effective for insomnia

Most Useful Review

I have bought this product three times and find it very beneficial for my chronic insomnia.

Athlete’s Foot details

Foot numbness has disappeared. My blood circulation is improved, and I really like this product. I used to experience cramping in my foot constantly, but after taking Omega for some time, those issues have resolved.

Chest Pain details

Eicosapentaenoic acid showed mixed results

Improvement of coronary vasomotion with eicosapentaenoic acid does not inhibit acetylcholine-induced coronary vasospasm in patients with variant angina.

Most Relevant Research

We examined how eicosapentaenoic acid (EPA), a key ingredient found in fish oil, impacts chest pain in patients with variant angina. Our study followed 22 individuals with this condition, where we infused acetylcholine, a substance known to cause coronary vasospasm, both before and after a four-month course of EPA treatment (1.8 g/day for 12 patients).

In the group that did not receive EPA, we observed no changes in how their coronary arteries responded to acetylcholine over time. However, for those treated with EPA, the results were quite intriguing. In non-spastic areas, the response shifted from vasoconstriction (narrowing) to vasodilation (widening). This indicates a notable improvement in how these arteries are functioning.

Yet, when it came to spastic sites where vasospasm had occurred, the coronary arteries remained responsive to acetylcholine, and the vasospasm persisted despite the EPA treatment. Thus, while EPA enhanced coronary responsiveness in some areas, it did not eliminate the acetylcholine-induced coronary vasospasms associated with variant angina.

9.5

Not effective for chest pain

Most Useful Review

Omega-3s are crucial for health, known since the 1930s. However, I didn’t find any specific effect on my chest pain from this product. I experienced fishy burps, and while studies show benefits, my personal experience wasn’t satisfactory.

Gastritis details