Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 95 Researches
7.9
USERS' SCORE
Good
Based on 18 Reviews
8.8
Supplement Facts
Serving Size:  1 Veg Capsule
Amount Per Serving
%DV
Blend of 10 Strains of Probiotic Bacteria: Lactobacillus acidophilus (La-14), Bifidobacterium lactis (Bl-04),Lactobacillus plantarum (Lp-115), Lactobacillus casei (Lc-11),Lactobacillus rhamnosus (Lr-32), Lactobacillus paracasei (Lpc-37),Bifidobacterium breve (Bb-03), Streptococcus thermophilus (St-21),Lactobacillus salivarius (Ls-33), Bifidobacterium longum (BI-05)
100 Billion CFU
*

Top Medical Research Studies

9.5
Bifidobacterium lactis reduced diarrhea duration
We explored the impact of Bifidobacterium animalis subsp. lactis BLa80 on diarrhea in young children through a well-structured, randomized, double-blinded, placebo-controlled study.

Our findings show that children receiving the probiotic experienced a significantly shorter duration of diarrhea and a higher recovery rate compared to those given a placebo.

Notably, we also observed beneficial changes in gut microbiome composition and gene functions that promote immune response.

This evidence suggests that Bifidobacterium lactis can effectively support recovery from acute diarrhea in children.
Read More
9
Lactobacillus effectively reduces diarrhea
We explored the impact of Lactobacillus salivarius SNK-6 on treating and preventing diarrhea in pigeons. In our research, we compared healthy pigeons with those infected with specific strains of E. coli known to cause diarrhea. After administering L. salivarius SNK-6, we observed a notable reduction in diarrhea among treated pigeons, while control pigeons still experienced a 10% incidence of diarrhea. This suggests that boosting levels of Lactobacillus can help maintain a healthy balance in the gut, potentially preventing diarrhea in the future.
Read More
9
Bifidobacterium lactis helps reduce diarrhea
We evaluated the effectiveness of Bifidobacterium lactis XLTG11 in treating acute watery diarrhea in children through a rigorous randomized, double-blind, placebo-controlled trial.

Children who received the probiotic alongside their conventional treatment had significantly shorter diarrhea durations and hospital stays compared to those who only got standard care. Additionally, those taking Bifidobacterium showed better improvement rates and healthier gut microbiomes after treatment.

Overall, this study suggests that Bifidobacterium lactis can be a beneficial adjunct therapy for children suffering from diarrhea.
Read More

Most Useful Reviews

10
No more diarrhea
From a small dose of 5 billion to 25 billion, I am now taking 100 billion per day. I feel excellent, with no more issues of diarrhea or constipation in my daily life. I used to constantly need to find a restroom. I highly recommend this supplement for its numerous benefits to overall health.
Read More
9.5
Normal bowel movement
My personal experience began on the first day I took it. Within three hours, I felt empty and experienced gurgling sounds in my abdomen. After eating, I had gas issues but later returned to normal. There was no diarrhea or constipation, and the bloating subsided significantly. I am grateful for this change.
Read More
9.3
Normal stools again
I tried different routines for taking it, but found that taking it on an empty stomach each morning worked best for me. I often dealt with diarrhoea and loose stools, but after using this product, my stools returned to normal. I’m happy I can now enjoy coffee without concern!
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 95 Researches
7.9
  • All Researches
9.5
Probiotics aid IBS-D treatment outcomes
We explored the impact of Lactobacillus acidophilus and L. plantarum on patients suffering from diarrhea-predominant irritable bowel syndrome (IBS-D). In a randomized, single-blinded clinical trial of 100 patients, some received standard IBS treatment alone while others added probiotics to their therapy.

After 12 weeks, both groups saw improvements, but those who took probiotics reported significantly better outcomes. Patients using probiotics experienced greater reductions in IBS symptoms, achieving near complete relief, while some on standard treatment still faced moderate symptoms. This suggests probiotics could enhance IBS management.
Read More
9.5
Probiotics aid IBS-D treatment outcomes
We explored the impact of Lactobacillus acidophilus and L. plantarum on patients suffering from diarrhea-predominant irritable bowel syndrome (IBS-D). In a randomized, single-blinded clinical trial of 100 patients, some received standard IBS treatment alone while others added probiotics to their therapy.

After 12 weeks, both groups saw improvements, but those who took probiotics reported significantly better outcomes. Patients using probiotics experienced greater reductions in IBS symptoms, achieving near complete relief, while some on standard treatment still faced moderate symptoms. This suggests probiotics could enhance IBS management.
Read More
9.5
Lactobacillus shows promise for diarrhea
We aimed to explore how Lactobacillus acidophilus can help relieve diarrhea symptoms associated with irritable bowel syndrome (IBS) and antibiotic-associated diarrhea (AAD).

In a study with 54 patients, those taking the probiotic Neobiotic Lactobalance® for 21 days saw significant reductions in diarrhea severity and abdominal pain, with scores dropping impressively on the Gastrointestinal Symptom Rating Scale.

Fecal analysis indicated improved intestinal health, highlighting Lactobacillus's potential benefits for those struggling with these conditions.
Read More
9.5
Probiotics improve H. pylori treatments
We analyzed various studies on incorporating probiotics into treatments for Helicobacter pylori (H. pylori) infection. Our findings revealed that adding probiotics like Bifidobacterium longum improved the eradication rate significantly.

Specifically, we noted that the probiotic group experienced fewer side effects, including diarrhea, nausea, and abdominal pain. This suggests that probiotics could not only enhance the effectiveness of H. pylori treatment but also make it more comfortable for patients. Overall, these results support the use of probiotics in gastric therapies.
Read More
9.5
Bifidobacterium longum shows promise
We conducted a randomized double-blind, placebo-controlled trial with 200 participants to see how well the probiotic CECT 7347 (ES1) and its heat-treated version (HT-ES1) could help those suffering from diarrhea-predominant irritable bowel syndrome (IBS-D). After 12 weeks of treatment, both ES1 and HT-ES1 showed significant improvements in symptom severity, with marked reductions in IBS-SSS scores compared to the placebo.

Secondary benefits included better stool consistency and quality of life, making these treatments promising options for managing IBS-D symptoms. These findings reflect meaningful advancements in probiotic and postbiotic solutions.
Read More

User Reviews

USERS' SCORE
Good
Based on 18 Reviews
8.8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
10
No more diarrhea
From a small dose of 5 billion to 25 billion, I am now taking 100 billion per day. I feel excellent, with no more issues of diarrhea or constipation in my daily life. I used to constantly need to find a restroom. I highly recommend this supplement for its numerous benefits to overall health.
Read More
9.5
Normal bowel movement
My personal experience began on the first day I took it. Within three hours, I felt empty and experienced gurgling sounds in my abdomen. After eating, I had gas issues but later returned to normal. There was no diarrhea or constipation, and the bloating subsided significantly. I am grateful for this change.
Read More
9.3
Normal stools again
I tried different routines for taking it, but found that taking it on an empty stomach each morning worked best for me. I often dealt with diarrhoea and loose stools, but after using this product, my stools returned to normal. I’m happy I can now enjoy coffee without concern!
Read More
9.5
Diarrhea resolved
Excellent products! After years of suffering from symptoms related to candida overgrowth, I often experienced daily diarrhoea. Fortunately, within about a month of starting the 100 billion probiotics, my diarrhoea disappeared.
Read More
8.8
Reduced frequency
My intestinal condition has greatly improved! The frequency of my diarrhoea has significantly decreased. Combining it with dietary fibre has helped harden my stools, making bowel movements easier. I’ve also noticed a reduction in my hay fever symptoms.
Read More

Frequently Asked Questions

No FAQs are available for this product and symptom.

References

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  2. Hashem B, Gaston M, Carlisle JD, Van Wick P. COMPARISON OF HAND-REARED PRONGHORN () MILK REPLACER COMPOSITIONS AND GROWTH RATES. J Zoo Wildl Med. 2024;55:1056. doi:10.1638/2023-0112
  3. Wei Q, Song LY, Rao R, Yang HW, Wen YP, et al. The Impact of Combined Therapy with Lactobacillus acidophilus and Montmorillonite Powder on the Inflammatory Response in Pediatric Rotavirus Enteritis. Int Arch Allergy Immunol. 2024. doi:10.1159/000542593
  4. Jeong JJ, Jin YJ, Ganesan R, Park HJ, Min BH, et al. Multistrain Probiotics Alleviate Diarrhea by Modulating Microbiome-Derived Metabolites and Serotonin Pathway. Probiotics Antimicrob Proteins. 2024. doi:10.1007/s12602-024-10232-4
  5. Alharbi BF, Alateek AA. Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review. Travel Med Infect Dis. 2024;59:102703. doi:10.1016/j.tmaid.2024.102703
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  8. Shanshal SA, Alsaaty MH, Al-Qazaz H, Al-Zidan RN. Two Lactobacilli strains as adjuvant therapy in the management of irritable bowel syndrome: a randomized control trial. Ceska Slov Farm. 2024;73:233.
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  10. Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. doi:10.33029/0042-8833-2023-92-4-92-103
  11. Lukasik J, Dierikx T, Besseling-van der Vaart I, de Meij T, Szajewska H. Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial. JAMA Pediatr. 2022;176:860. doi:10.1001/jamapediatrics.2022.1973
  12. Huang R, Xing HY, Liu HJ, Chen ZF, Tang BB. Efficacy of probiotics in the treatment of acute diarrhea in children: a systematic review and meta-analysis of clinical trials. Transl Pediatr. 2021;10:3248. doi:10.21037/tp-21-511
  13. Gandhar JS, De UK, Kala A, Malik YS, Yadav S, et al. Efficacy of Microencapsulated Probiotic as Adjunct Therapy on Resolution of Diarrhea, Copper-Zinc Homeostasis, Immunoglobulins, and Inflammatory Markers in Serum of Spontaneous Rotavirus-Infected Diarrhoetic Calves. Probiotics Antimicrob Proteins. 2022;14:1054. doi:10.1007/s12602-021-09862-9
  14. Kumar M, Kala A, Chaudhary LC, Agarwal N, Kochewad SA. Microencapsulated and Lyophilized Lactobacillus acidophilus Improved Gut Health and Immune Status of Preruminant Calves. Probiotics Antimicrob Proteins. 2022;14:523. doi:10.1007/s12602-021-09821-4
  15. Chorawala MR, Chauhan S, Patel R, Shah G. Cell Wall Contents of Probiotics (Lactobacillus species) Protect Against Lipopolysaccharide (LPS)-Induced Murine Colitis by Limiting Immuno-inflammation and Oxidative Stress. Probiotics Antimicrob Proteins. 2021;13:1005. doi:10.1007/s12602-020-09738-4
  16. Gunaratnam S, Diarra C, Paquette PD, Ship N, Millette M, et al. The Acid-Dependent and Independent Effects of Lactobacillus acidophilus CL1285, Lacticaseibacillus casei LBC80R, and Lacticaseibacillus rhamnosus CLR2 on Clostridioides difficile R20291. Probiotics Antimicrob Proteins. 2021;13:949. doi:10.1007/s12602-020-09729-5
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  18. Chen K, Zeng K, Jin S, Ma Y, Cai L, et al. LRa05 in the treatment of acute diarrhea in children: a randomized controlled trial. Front Nutr. 2024;11:1479186. doi:10.3389/fnut.2024.1479186
  19. Gwee KA, Lee WRW, Chua Q, Chiou FK, Aw MM, et al. The evidence for probiotics in the treatment of digestive disorders in the pediatric population. J Gastroenterol Hepatol. 2025;40:41. doi:10.1111/jgh.16809
  20. Shah J, Adnan SH, Yousaf MS, Din SJU, Haq MU, et al. A Multi-Hospital Comparative Study on the Efficacy of Probiotics Versus Placebo in Preventing Antibiotic-Associated Diarrhea in Adult Patients. Cureus. 2024;16:e70881. doi:10.7759/cureus.70881
  21. Shawky LM, Abo El Wafa SM, Behery M, Bahr MH, Abu Alnasr MT, et al. Lactobacillus rhamnosus GG and Tannic Acid Synergistically Promote the Gut Barrier Integrity in a Rat Model of Experimental Diarrhea via Selective Immunomodulatory Cytokine Targeting. Mol Nutr Food Res. 2024;68:e2400295. doi:10.1002/mnfr.202400295
  22. Anvarifard P, Anbari M, Ghalichi F, Ghoreishi Z, Zarezadeh M. The effectiveness of probiotics as an adjunct therapy in patients under mechanical ventilation: an umbrella systematic review and meta-analysis. Food Funct. 2024;15:5737. doi:10.1039/d3fo04653b
  23. Alharbi BF, Alateek AA. Investigating the influence of probiotics in preventing Traveler's diarrhea: Meta-analysis based systematic review. Travel Med Infect Dis. 2024;59:102703. doi:10.1016/j.tmaid.2024.102703
  24. Abdulah DM, Sulaiman SJ, Ahmed ZW. Effect of probiotics plus zinc supplementation on clinical outcomes of infants and children with acute infectious diarrhea: a randomized controlled trial. Clin Exp Pediatr. 2024;67:203. doi:10.3345/cep.2023.01340
  25. Waitzberg D, Guarner F, Hojsak I, Ianiro G, Polk DB, et al. Can the Evidence-Based Use of Probiotics (Notably Saccharomyces boulardii CNCM I-745 and Lactobacillus rhamnosus GG) Mitigate the Clinical Effects of Antibiotic-Associated Dysbiosis?. Adv Ther. 2024;41:901. doi:10.1007/s12325-024-02783-3
  26. Saviano A, Petruzziello C, Cancro C, Macerola N, Petti A, et al. The Efficacy of a Mix of Probiotics ( LMG P-27481 and GG ATCC 53103) in Preventing Antibiotic-Associated Diarrhea and Infection in Hospitalized Patients: Single-Center, Open-Label, Randomized Trial. Microorganisms. 2024;12. doi:10.3390/microorganisms12010198
  27. Poeta M, Cioffi V, Tarallo A, Damiano C, Lo Vecchio A, et al. Postbiotic Preparation of against Diarrhea and Oxidative Stress Induced by Spike Protein of SARS-CoV-2 in Human Enterocytes. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12101878
  28. Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. doi:10.33029/0042-8833-2023-92-4-92-103
  29. Mego M, Danis R, Chovanec J, Jurisova S, Bystricky B, et al. Randomized double-blind, placebo-controlled multicenter phase III study of prevention of irinotecan-induced diarrhea by a probiotic mixture containing Bifidobacterium BB-12 LGG in colorectal cancer patients. Front Oncol. 2023;13:1168654. doi:10.3389/fonc.2023.1168654
  30. Yang Q, Hu Z, Lei Y, Li X, Xu C, et al. Overview of systematic reviews of probiotics in the prevention and treatment of antibiotic-associated diarrhea in children. Front Pharmacol. 2023;14:1153070. doi:10.3389/fphar.2023.1153070
  31. Niu H, Zhou X, Liu P, Wu Y, Lyu L, et al. Lactobacillus rhamnosus MN-431 Metabolic Tryptophan Alleviates Complementary Food-Induced Diarrhea through PXR-NF-κB Pathway and AHR-Th17 Cell Response Pathways. Mol Nutr Food Res. 2023;67:e2200530. doi:10.1002/mnfr.202200530
  32. Li J, Li Q, Wu Q, Gao N, Wang Z, et al. Exopolysaccharides of Lactobacillus rhamnosus GG ameliorate Salmonella typhimurium-induced intestinal inflammation via the TLR4/NF-κB/MAPK pathway. J Anim Sci Biotechnol. 2023;14:23. doi:10.1186/s40104-023-00830-7
  33. He Q, Lu S, Wang J, Xu C, Qu W, et al. and Berberine Alleviated Yak Calves' Diarrhea via Accommodating Oxidation Resistance, Inflammatory Factors, and Intestinal Microbiota. Animals (Basel). 2024;14. doi:10.3390/ani14162419
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  38. Lukasik J, Dierikx T, Besseling-van der Vaart I, de Meij T, Szajewska H. Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial. JAMA Pediatr. 2022;176:860. doi:10.1001/jamapediatrics.2022.1973
  39. Sun Z, Li H, Li Y, Qiao J. , a Potential Probiotic to Improve the Health of LPS-Challenged Piglet Intestine by Alleviating Inflammation as Well as Oxidative Stress in a Dose-Dependent Manner During Weaning Transition. Front Vet Sci. 2020;7:547425. doi:10.3389/fvets.2020.547425
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  50. Shah J, Adnan SH, Yousaf MS, Din SJU, Haq MU, et al. A Multi-Hospital Comparative Study on the Efficacy of Probiotics Versus Placebo in Preventing Antibiotic-Associated Diarrhea in Adult Patients. Cureus. 2024;16:e70881. doi:10.7759/cureus.70881
  51. Moreno-Muñoz JA, Ojeda JD, López JJ. A Probiotic Bacterium with Activity against the Most Frequent Bacteria and Viruses Causing Pediatric Diarrhea: subsp. CECT 7210 ( IM1). Microorganisms. 2024;12. doi:10.3390/microorganisms12061183
  52. Srivastava S, Basak U, Naghibi M, Vijayakumar V, Parihar R, et al. A randomized double-blind, placebo-controlled trial to evaluate the safety and efficacy of live CECT 7347 (ES1) and heat-treated CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome. Gut Microbes. 2024;16:2338322. doi:10.1080/19490976.2024.2338322
  53. Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. doi:10.33029/0042-8833-2023-92-4-92-103
  54. Lenoir M, Wienke J, Fardao-Beyler F, Roese N. An 8-Week Course of Bifidobacterium longum 35624 Is Associated with a Reduction in the Symptoms of Irritable Bowel Syndrome. Probiotics Antimicrob Proteins. 2025;17:315. doi:10.1007/s12602-023-10151-w
  55. Chen K, Jin S, Ma Y, Cai L, Xu P, et al. Adjunctive efficacy of Lactis XLTG11 for Acute diarrhea in children: A randomized, blinded, placebo-controlled study. Nutrition. 2023;111:112052. doi:10.1016/j.nut.2023.112052
  56. Li W, Zhang S, Wang Y, Bian H, Yu S, et al. Complex probiotics alleviate ampicillin-induced antibiotic-associated diarrhea in mice. Front Microbiol. 2023;14:1156058. doi:10.3389/fmicb.2023.1156058
  57. Mizutani Y, Kawamoto S, Takahashi M, Doi H, Wakida K, et al. Efficacy and Safety of Synbiotics in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation: A Randomized, Double-blinded, Placebo-controlled Pilot Study. Intern Med. 2023;62:2949. doi:10.2169/internalmedicine.1314-22
  58. Yalcin G, Demirbas F, Bacalan F, Toy EB. Evaluation of treatment in acute gastroenteritis: A comparative study. J Pak Med Assoc. 2022;72:2019. doi:10.47391/JPMA.4438
  59. Li W, Kai L, Jiang Z, He H, Yang M, et al. , and Reversed ETEC-Inducing Intestinal Inflammation in Mice. Microorganisms. 2022;10. doi:10.3390/microorganisms10122350
  60. Yakovenko EP, Strokova TV, Ivanov AN, Iakovenko AV, Gioeva IZ, et al. [The effectiveness of a probiotic containing Bifidobacterium longum BB-46 and Enterococcus faecium ENCfa-68 in the treatment of post-infectious irritable bowel syndrome. Prospective randomized comparative study]. Ter Arkh. 2022;94:180. doi:10.26442/00403660.2022.02.201368
  61. Shin SY, Park S, Moon JM, Kim K, Kim JW, et al. Compositional Changes in the Gut Microbiota of Responders and Non-responders to Probiotic Treatment Among Patients With Diarrhea-predominant Irritable Bowel Syndrome: A Post Hoc Analysis of a Randomized Clinical Trial. J Neurogastroenterol Motil. 2022;28:642. doi:10.5056/jnm21202
  62. Álvarez-Mercado AI, Plaza-Díaz J, de Almagro MC, Gil Á, Moreno-Muñoz JA, et al. subsp. CECT 7210 Reduces Inflammatory Cytokine Secretion in Caco-2 Cells Cultured in the Presence of CECT 515. Int J Mol Sci. 2022;23. doi:10.3390/ijms231810813
  63. Moreno-Muñoz JA, Martín-Palomas M, Jiménez López J. [Bifidobacterium longum subsp. infantis CECT 7210 (B. infantis IM-1®) shows activity against intestinal pathogens]. Nutr Hosp. 2022;39:65. doi:10.20960/nh.04315
  64. Uttarwar RG, Mekonnen SA, Van Beeck W, Wang A, Finnegan P, et al. Effects of Bifidobacterium animalis subsp. lactis BB-12 and yogurt on mice during oral antibiotic administration. Microbiol Res. 2024;286:127794. doi:10.1016/j.micres.2024.127794
  65. Jeong JJ, Jin YJ, Ganesan R, Park HJ, Min BH, et al. Multistrain Probiotics Alleviate Diarrhea by Modulating Microbiome-Derived Metabolites and Serotonin Pathway. Probiotics Antimicrob Proteins. 2024. doi:10.1007/s12602-024-10232-4
  66. Chen K, Jin S, Ma Y, Cai L, Xu P, et al. Adjudicative efficacy of Bifidobacterium animalis subsp. lactis BLa80 in treating acute diarrhea in children: a randomized, double-blinded, placebo-controlled study. Eur J Clin Nutr. 2024;78:501. doi:10.1038/s41430-024-01428-6
  67. Drozdov VN, Shikh EV, Astapovskii AA, Khalaidzheva KN, Solovieva SA, et al. [Clinical efficacy of a modern probiotic for the correction of intestinal microflora in patients with irritable bowel syndrome with diarrhea and antibiotic-associated diarrhea]. Vopr Pitan. 2023;92:92. doi:10.33029/0042-8833-2023-92-4-92-103
  68. Chen K, Jin S, Ma Y, Cai L, Xu P, et al. Adjunctive efficacy of Lactis XLTG11 for Acute diarrhea in children: A randomized, blinded, placebo-controlled study. Nutrition. 2023;111:112052. doi:10.1016/j.nut.2023.112052
  69. Pang J, Liu Y, Kang L, Ye H, Zang J, et al. Bifidobacterium animalis Promotes the Growth of Weaning Piglets by Improving Intestinal Development, Enhancing Antioxidant Capacity, and Modulating Gut Microbiota. Appl Environ Microbiol. 2022;88:e0129622. doi:10.1128/aem.01296-22
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