We investigated a new compound called NATOH, which combines vitamin E with properties of natural anti-inflammatory agents.
In our study, we tested its effects in mice prone to atherosclerosis, specifically those lacking the Apo E gene.
We found that NATOH not only mimicked the antioxidant abilities of vitamin E but also significantly reduced inflammation and improved atherosclerosis conditions in these mice.
This suggests that NATOH could be a promising option for preventing atherosclerosis in future clinical applications.
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Vitamin E may improve heart healthAttenuation of atherogenic apo B-48-dependent hyperlipidemia and high density lipoprotein remodeling induced by vitamin C and E combination and their beneficial effect on lethal ischemic heart disease in mice.
Presents potential health implications
We explored the potential benefits of combining vitamins C and E on heart health in mice with arteriosclerosis. By monitoring mice on an atherogenic diet, we found that this combination significantly lowered unhealthy cholesterol and triglyceride levels.
The vitamins supported better function in high-density lipoprotein (HDL), reducing inflammation markers and helping to remodel HDL particles. This suggests a cardioprotective effect and improved overall health in the studied mice. However, the implications for human health remain unclear.
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Vitamin E effect on atherosclerosisThe effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein-E deficient mice.
High relevance for cardiovascular health
We investigated how a form of vitamin E, tocopheryl phosphate (TPM), impacts the development of atherosclerosis using apolipoprotein-E deficient mice. By comparing TPM with traditional vitamin E, we found that TPM significantly reduced atherosclerotic lesions and inflammation indicators.
Mice receiving TPM experienced up to a 44% reduction in lesions. In contrast, those on a standard vitamin E supplement showed no significant benefits.
Overall, our findings suggest that TPM may help slow down the progression of artery hardening, primarily by reducing oxidative stress and inflammation.
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We examined the effectiveness of tocotrienol and tocopherol, two forms of vitamin E, in treating atherosclerotic cardiovascular diseases. Our systematic review analyzed studies published between 2002 and early 2023 to evaluate their safety and health benefits.
Tocotrienol emerged as a promising option, significantly lowering cholesterol and markers of inflammation. In contrast, tocopherol's results were mixed and potentially indicated increased mortality risk. This evidence positions tocotrienol as a safer alternative for improving cardiovascular health.
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We examined the impact of vitamin E on patients with severe lower limb atherosclerosis after reconstructive surgery.
Sixty patients were divided into two groups: one received vitamin E daily for a month, while the other followed standard therapy.
After treatment, we found that vitamin E significantly reduced the level of the harmful Bax protein and raised the protective Bcl-2 protein.
This suggests that vitamin E could enhance recovery by balancing apoptosis markers in these patients.
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