Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 1 tbsp (15 ml)
Amount Per Serving
%DV
Calories
120
Total Fat
14 g
18%
Saturated Fat
2.5 g
13%
Polyunsaturated Fat
8 g
Monounsaturated Fat
2 g
Sodium
0 mg
0%
Total Carbohydrate
0 g
0%
Protein
0 g
Vitamin E
20 mg
130%
Top Medical Research Studies
8
We examined the effects of gamma-tocopherol, a major form of vitamin E, on cancer treatment and prevention. This powerful antioxidant is noted for its ability to combat oxidative stress, which plays a significant role in the development and progression of various cancers.
In several studies, we observed that gamma-tocopherol not only neutralizes harmful reactive oxygen species but also exhibits anti-inflammatory properties. These characteristics help reduce chronic inflammation tied to cancer risks. Furthermore, it has shown the potential to inhibit tumor growth, induce cancer cell death, and restrict blood vessel formation that tumors require to grow.
Specifically, findings indicated that gamma-tocopherol is particularly effective in cancers such as prostate, lung, and colon. With promising results from both preclinical and clinical trials, there is a growing interest in how this natural compound can be beneficial in cancer management.
While we noted excellent tolerance at normal doses, it’s essential to consider careful monitoring at higher levels to avoid any adverse effects. Hence, we believe that ongoing research and advancements in drug delivery methods could further enhance its effectiveness.
In several studies, we observed that gamma-tocopherol not only neutralizes harmful reactive oxygen species but also exhibits anti-inflammatory properties. These characteristics help reduce chronic inflammation tied to cancer risks. Furthermore, it has shown the potential to inhibit tumor growth, induce cancer cell death, and restrict blood vessel formation that tumors require to grow.
Specifically, findings indicated that gamma-tocopherol is particularly effective in cancers such as prostate, lung, and colon. With promising results from both preclinical and clinical trials, there is a growing interest in how this natural compound can be beneficial in cancer management.
While we noted excellent tolerance at normal doses, it’s essential to consider careful monitoring at higher levels to avoid any adverse effects. Hence, we believe that ongoing research and advancements in drug delivery methods could further enhance its effectiveness.
Read More
9
We explored how specific changes to the METTL14 protein affect cancer, particularly in acute myeloid leukemia (AML). By examining the RG-rich region of METTL14, we discovered that a special form of arginine methylation called symmetric dimethylation, specifically at positions R425 and R445, plays a vital role in enhancing its function.
Our research revealed that this modification not only improves the activity of the METTL3:METTL14 complex but also influences which genes get expressed in cancer cells. We found that the presence of symmetric dimethylarginines helps the complex deposit a crucial chemical mark, known as m6A, on RNA, which is essential for the regulation of gene activity.
Furthermore, we conducted a series of experiments that indicated a potential therapeutic angle in targeting the METTL3 and PRMT5 proteins. When both are inhibited, we observed a significant drop in the expression of genes important for AML cell growth, hinting at new possibilities for treating this challenging cancer. Overall, this study highlights the intricate relationship between protein modifications and cancer biology, emphasizing the potential for more targeted approaches in therapy.
Our research revealed that this modification not only improves the activity of the METTL3:METTL14 complex but also influences which genes get expressed in cancer cells. We found that the presence of symmetric dimethylarginines helps the complex deposit a crucial chemical mark, known as m6A, on RNA, which is essential for the regulation of gene activity.
Furthermore, we conducted a series of experiments that indicated a potential therapeutic angle in targeting the METTL3 and PRMT5 proteins. When both are inhibited, we observed a significant drop in the expression of genes important for AML cell growth, hinting at new possibilities for treating this challenging cancer. Overall, this study highlights the intricate relationship between protein modifications and cancer biology, emphasizing the potential for more targeted approaches in therapy.
Read More
9
Our research delved into the role of interleukin-19 (IL-19) in glioblastoma, a particularly aggressive brain cancer known for its ability to evade treatments. By analyzing RNA sequencing data from patient samples, we found that IL-19 is linked to poor survival rates and is involved in creating an immunosuppressive environment that helps the tumor thrive.
We observed that blocking IL-19 led to significant reductions in tumor progression in both treatment-sensitive and resistant glioblastoma models. This blockade also sparked changes in the immune landscape of the tumors, particularly increasing the presence of immune cells like dendritic cells that help fight cancer. Notably, IL-19 suppression reprogrammed tumor-associated macrophages, making them less supportive of tumor growth and enhancing T cell activation.
Additionally, we uncovered a new signaling pathway involving IL-19 that helps glioblastoma cells migrate and invade other tissues. To bring these findings closer to real-world applications, we developed a new type of nanoparticles designed to specifically target IL-19 in glioblastoma tissues, illustrating their potential both as a therapeutic tool and a diagnostic marker through advanced imaging techniques.
Overall, our findings present IL-19 as a promising target for enhancing cancer treatment by reversing immune suppression and limiting the invasive potential of glioblastoma cells.
We observed that blocking IL-19 led to significant reductions in tumor progression in both treatment-sensitive and resistant glioblastoma models. This blockade also sparked changes in the immune landscape of the tumors, particularly increasing the presence of immune cells like dendritic cells that help fight cancer. Notably, IL-19 suppression reprogrammed tumor-associated macrophages, making them less supportive of tumor growth and enhancing T cell activation.
Additionally, we uncovered a new signaling pathway involving IL-19 that helps glioblastoma cells migrate and invade other tissues. To bring these findings closer to real-world applications, we developed a new type of nanoparticles designed to specifically target IL-19 in glioblastoma tissues, illustrating their potential both as a therapeutic tool and a diagnostic marker through advanced imaging techniques.
Overall, our findings present IL-19 as a promising target for enhancing cancer treatment by reversing immune suppression and limiting the invasive potential of glioblastoma cells.
Read More
Most Useful Reviews
7.5
Skin cancer prevention
34 people found this helpful
The yellow colour of the oil may appear darker than others. Its texture is rather heavy, and while the quality is satisfactory, the smell resembles oatmeal and lingers. Despite this, its benefits outweigh the drawbacks, as it accelerates healing for skin wounds and burns, reduces scar appearance, alleviates itching, and helps prevent skin cancer. Additionally, it can lighten skin tone and address hair breakage and stretch marks. Being a larger package, it's advisable to use it in mixtures for hair or skin, as it should be diluted for effective use. If my comment helps, please give a like 💗
Read More
7.5
Cancer risk reduction
1 people found this helpful
Amazing! Wheat germ oil, derived from wheat germ, is nutrient-rich, providing vitamin E, essential fatty acids, proteins, and fibre. Its benefits encompass improved skin, hair, and nail health, bolstered immune and heart health, enhanced digestion, reduced inflammation, and a lowered risk of chronic conditions, including breast cancer and heart disease.
Read More
4
Cancer risk reduction
1 people found this helpful
Wheat germ oil, rich in Vitamin E, is a potent antioxidant that aids in blood sugar control. Its high fibre content helps the body manage blood glucose levels and reduces cancer risk. Additionally, it promotes healthy hair and enhances skin health due to its omega-3 fatty acid content, which supports blood circulation and lowers cholesterol levels. However, it's important to be cautious of its omega-6 fatty acids, which may raise cholesterol if consumed excessively.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 23 Researches
8
- All Researches
9
We explored how specific changes to the METTL14 protein affect cancer, particularly in acute myeloid leukemia (AML). By examining the RG-rich region of METTL14, we discovered that a special form of arginine methylation called symmetric dimethylation, specifically at positions R425 and R445, plays a vital role in enhancing its function.
Our research revealed that this modification not only improves the activity of the METTL3:METTL14 complex but also influences which genes get expressed in cancer cells. We found that the presence of symmetric dimethylarginines helps the complex deposit a crucial chemical mark, known as m6A, on RNA, which is essential for the regulation of gene activity.
Furthermore, we conducted a series of experiments that indicated a potential therapeutic angle in targeting the METTL3 and PRMT5 proteins. When both are inhibited, we observed a significant drop in the expression of genes important for AML cell growth, hinting at new possibilities for treating this challenging cancer. Overall, this study highlights the intricate relationship between protein modifications and cancer biology, emphasizing the potential for more targeted approaches in therapy.
Our research revealed that this modification not only improves the activity of the METTL3:METTL14 complex but also influences which genes get expressed in cancer cells. We found that the presence of symmetric dimethylarginines helps the complex deposit a crucial chemical mark, known as m6A, on RNA, which is essential for the regulation of gene activity.
Furthermore, we conducted a series of experiments that indicated a potential therapeutic angle in targeting the METTL3 and PRMT5 proteins. When both are inhibited, we observed a significant drop in the expression of genes important for AML cell growth, hinting at new possibilities for treating this challenging cancer. Overall, this study highlights the intricate relationship between protein modifications and cancer biology, emphasizing the potential for more targeted approaches in therapy.
Read More
9
Our research delved into the role of interleukin-19 (IL-19) in glioblastoma, a particularly aggressive brain cancer known for its ability to evade treatments. By analyzing RNA sequencing data from patient samples, we found that IL-19 is linked to poor survival rates and is involved in creating an immunosuppressive environment that helps the tumor thrive.
We observed that blocking IL-19 led to significant reductions in tumor progression in both treatment-sensitive and resistant glioblastoma models. This blockade also sparked changes in the immune landscape of the tumors, particularly increasing the presence of immune cells like dendritic cells that help fight cancer. Notably, IL-19 suppression reprogrammed tumor-associated macrophages, making them less supportive of tumor growth and enhancing T cell activation.
Additionally, we uncovered a new signaling pathway involving IL-19 that helps glioblastoma cells migrate and invade other tissues. To bring these findings closer to real-world applications, we developed a new type of nanoparticles designed to specifically target IL-19 in glioblastoma tissues, illustrating their potential both as a therapeutic tool and a diagnostic marker through advanced imaging techniques.
Overall, our findings present IL-19 as a promising target for enhancing cancer treatment by reversing immune suppression and limiting the invasive potential of glioblastoma cells.
We observed that blocking IL-19 led to significant reductions in tumor progression in both treatment-sensitive and resistant glioblastoma models. This blockade also sparked changes in the immune landscape of the tumors, particularly increasing the presence of immune cells like dendritic cells that help fight cancer. Notably, IL-19 suppression reprogrammed tumor-associated macrophages, making them less supportive of tumor growth and enhancing T cell activation.
Additionally, we uncovered a new signaling pathway involving IL-19 that helps glioblastoma cells migrate and invade other tissues. To bring these findings closer to real-world applications, we developed a new type of nanoparticles designed to specifically target IL-19 in glioblastoma tissues, illustrating their potential both as a therapeutic tool and a diagnostic marker through advanced imaging techniques.
Overall, our findings present IL-19 as a promising target for enhancing cancer treatment by reversing immune suppression and limiting the invasive potential of glioblastoma cells.
Read More
9
We set out to explore the potential of a lipase enzyme derived from the bacterial strain Pseudomonas aeruginosa in treating liver cancer. The goal was to see how this microbial protein might impact cancer cells, specifically by targeting the BCL-2 gene, which plays a significant role in cancer cell survival.
To achieve this, we isolated several strains of P. aeruginosa from various biological samples and identified one with the highest lipase activity. After enhancing the enzyme's production through random mutagenesis, we used submerged fermentation techniques to optimize the growth conditions. Under these optimized parameters, we achieved a notable increase in lipase activity, which we then purified for testing.
Our results were encouraging. The purified lipase proved stable and effective, exhibiting significant anticancer activity in cultured liver cancer cells, known as HepG-2. Notably, we found that treatment with the enzyme led to a substantial reduction in Bcl-2 gene expression, promoting cancer cell death through apoptosis. Importantly, the lipase showed no harmful effects on normal cells, suggesting its potential as a safe therapeutic option for liver cancer.
Overall, our findings suggest that lipase from P. aeruginosa could be a promising new approach to tackle hepatocellular carcinoma, addressing some of the shortcomings in existing cancer treatments.
To achieve this, we isolated several strains of P. aeruginosa from various biological samples and identified one with the highest lipase activity. After enhancing the enzyme's production through random mutagenesis, we used submerged fermentation techniques to optimize the growth conditions. Under these optimized parameters, we achieved a notable increase in lipase activity, which we then purified for testing.
Our results were encouraging. The purified lipase proved stable and effective, exhibiting significant anticancer activity in cultured liver cancer cells, known as HepG-2. Notably, we found that treatment with the enzyme led to a substantial reduction in Bcl-2 gene expression, promoting cancer cell death through apoptosis. Importantly, the lipase showed no harmful effects on normal cells, suggesting its potential as a safe therapeutic option for liver cancer.
Overall, our findings suggest that lipase from P. aeruginosa could be a promising new approach to tackle hepatocellular carcinoma, addressing some of the shortcomings in existing cancer treatments.
Read More
9
We conducted a phase 3 clinical trial called HARMONi-2, comparing the effectiveness of a new drug, ivonescimab, with the established treatment, pembrolizumab, for patients with advanced non-small cell lung cancer that tests positive for PD-L1. This study focused on individuals who had not received prior treatment and involved a thorough process of random assignment to ensure fairness, as both drugs are administered every three weeks.
Our findings revealed that patients receiving ivonescimab had a significantly longer progression-free survival—the time during which their cancer did not worsen—compared to those on pembrolizumab. Specifically, the median progression-free survival was 11.1 months for ivonescimab versus only 5.8 months for pembrolizumab. Even when looking closely at subgroups of patients, including those with varying levels of PD-L1 expression, ivonescimab consistently showed better outcomes.
While both treatments presented challenges in terms of side effects, ivonescimab was found to have acceptable safety levels. Notably, serious treatment-related adverse events occurred in a smaller percentage of patients on ivonescimab compared to those on pembrolizumab. This suggests that ivonescimab might offer a new, effective first-line treatment option for patients combating this tough form of cancer.
Our findings revealed that patients receiving ivonescimab had a significantly longer progression-free survival—the time during which their cancer did not worsen—compared to those on pembrolizumab. Specifically, the median progression-free survival was 11.1 months for ivonescimab versus only 5.8 months for pembrolizumab. Even when looking closely at subgroups of patients, including those with varying levels of PD-L1 expression, ivonescimab consistently showed better outcomes.
While both treatments presented challenges in terms of side effects, ivonescimab was found to have acceptable safety levels. Notably, serious treatment-related adverse events occurred in a smaller percentage of patients on ivonescimab compared to those on pembrolizumab. This suggests that ivonescimab might offer a new, effective first-line treatment option for patients combating this tough form of cancer.
Read More
9
This study focuses on the innovative use of self-assembled nanoparticles to improve cancer treatment, particularly for triple-negative breast cancer. By leveraging computer-aided strategies, researchers identified key properties that guide the creation of these nanoparticles.
We observed that vitamin E, when combined with hydroxychloroquine and bortezomib, resulted in a unique nanoparticle formulation. This formulation not only helps reduce harmful M2-type tumor-associated macrophages but also induces a process known as immunogenic cell death in tumor cells.
In experiments conducted on mouse models, the nanoparticles displayed promising results. They effectively decreased levels of regulatory T cells and transforming growth factor-β while enhancing the presence of cytotoxic T lymphocytes. Moreover, they inhibited the secretion of a pro-inflammatory factor known as Interleukin-6, which can contribute to tumor growth and poor immune response.
The combination of vitamin E and other compounds showcases a dual modulation approach, potentially reprogramming the tumor microenvironment to enhance chemotherapy combined with immunotherapy.
However, while the study highlights potential benefits, it also suggests that isolating vitamin E's effect in cancer treatment is challenging due to its application alongside other treatments.
We observed that vitamin E, when combined with hydroxychloroquine and bortezomib, resulted in a unique nanoparticle formulation. This formulation not only helps reduce harmful M2-type tumor-associated macrophages but also induces a process known as immunogenic cell death in tumor cells.
In experiments conducted on mouse models, the nanoparticles displayed promising results. They effectively decreased levels of regulatory T cells and transforming growth factor-β while enhancing the presence of cytotoxic T lymphocytes. Moreover, they inhibited the secretion of a pro-inflammatory factor known as Interleukin-6, which can contribute to tumor growth and poor immune response.
The combination of vitamin E and other compounds showcases a dual modulation approach, potentially reprogramming the tumor microenvironment to enhance chemotherapy combined with immunotherapy.
However, while the study highlights potential benefits, it also suggests that isolating vitamin E's effect in cancer treatment is challenging due to its application alongside other treatments.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Skin cancer prevention
34 people found this helpful
The yellow colour of the oil may appear darker than others. Its texture is rather heavy, and while the quality is satisfactory, the smell resembles oatmeal and lingers. Despite this, its benefits outweigh the drawbacks, as it accelerates healing for skin wounds and burns, reduces scar appearance, alleviates itching, and helps prevent skin cancer. Additionally, it can lighten skin tone and address hair breakage and stretch marks. Being a larger package, it's advisable to use it in mixtures for hair or skin, as it should be diluted for effective use. If my comment helps, please give a like 💗
Read More
7.5
Cancer risk reduction
1 people found this helpful
Amazing! Wheat germ oil, derived from wheat germ, is nutrient-rich, providing vitamin E, essential fatty acids, proteins, and fibre. Its benefits encompass improved skin, hair, and nail health, bolstered immune and heart health, enhanced digestion, reduced inflammation, and a lowered risk of chronic conditions, including breast cancer and heart disease.
Read More
4
Cancer risk reduction
1 people found this helpful
Wheat germ oil, rich in Vitamin E, is a potent antioxidant that aids in blood sugar control. Its high fibre content helps the body manage blood glucose levels and reduces cancer risk. Additionally, it promotes healthy hair and enhances skin health due to its omega-3 fatty acid content, which supports blood circulation and lowers cholesterol levels. However, it's important to be cautious of its omega-6 fatty acids, which may raise cholesterol if consumed excessively.
Read More
Frequently Asked Questions
7.5
Cancer risk reduction
1 people found this helpful
Amazing! Wheat germ oil, derived from wheat germ, is nutrient-rich, providing vitamin E, essential fatty acids, proteins, and fibre. Its benefits encompass improved skin, hair, and nail health, bolstered immune and heart health, enhanced digestion, reduced inflammation, and a lowered risk of chronic conditions, including breast cancer and heart disease.
7.5
Skin cancer prevention
34 people found this helpful
The yellow colour of the oil may appear darker than others. Its texture is rather heavy, and while the quality is satisfactory, the smell resembles oatmeal and lingers. Despite this, its benefits outweigh the drawbacks, as it accelerates healing for skin wounds and burns, reduces scar appearance, alleviates itching, and helps prevent skin cancer. Additionally, it can lighten skin tone and address hair breakage and stretch marks. Being a larger package, it's advisable to use it in mixtures for hair or skin, as it should be diluted for effective use. If my comment helps, please give a like 💗
4
Cancer risk reduction
1 people found this helpful
Wheat germ oil, rich in Vitamin E, is a potent antioxidant that aids in blood sugar control. Its high fibre content helps the body manage blood glucose levels and reduces cancer risk. Additionally, it promotes healthy hair and enhances skin health due to its omega-3 fatty acid content, which supports blood circulation and lowers cholesterol levels. However, it's important to be cautious of its omega-6 fatty acids, which may raise cholesterol if consumed excessively.
8
We examined the effects of gamma-tocopherol, a major form of vitamin E, on cancer treatment and prevention. This powerful antioxidant is noted for its ability to combat oxidative stress, which plays a significant role in the development and progression of various cancers.
In several studies, we observed that gamma-tocopherol not only neutralizes harmful reactive oxygen species but also exhibits anti-inflammatory properties. These characteristics help reduce chronic inflammation tied to cancer risks. Furthermore, it has shown the potential to inhibit tumor growth, induce cancer cell death, and restrict blood vessel formation that tumors require to grow.
Specifically, findings indicated that gamma-tocopherol is particularly effective in cancers such as prostate, lung, and colon. With promising results from both preclinical and clinical trials, there is a growing interest in how this natural compound can be beneficial in cancer management.
While we noted excellent tolerance at normal doses, it’s essential to consider careful monitoring at higher levels to avoid any adverse effects. Hence, we believe that ongoing research and advancements in drug delivery methods could further enhance its effectiveness.
In several studies, we observed that gamma-tocopherol not only neutralizes harmful reactive oxygen species but also exhibits anti-inflammatory properties. These characteristics help reduce chronic inflammation tied to cancer risks. Furthermore, it has shown the potential to inhibit tumor growth, induce cancer cell death, and restrict blood vessel formation that tumors require to grow.
Specifically, findings indicated that gamma-tocopherol is particularly effective in cancers such as prostate, lung, and colon. With promising results from both preclinical and clinical trials, there is a growing interest in how this natural compound can be beneficial in cancer management.
While we noted excellent tolerance at normal doses, it’s essential to consider careful monitoring at higher levels to avoid any adverse effects. Hence, we believe that ongoing research and advancements in drug delivery methods could further enhance its effectiveness.
9
We observed that vitamin E succinate (VES) has the potential to serve as a tool for fighting cancer, particularly by targeting a protein called fat mass and obesity-associated protein (FTO), which plays a role in tumor growth. This study highlights how VES can act as a degrader of FTO, leading to its suppression, thereby hindering tumor progression and enhancing the effectiveness of immunotherapy.
When VES binds to both FTO and an associated protein called DTX2, it boosts the interaction between them. This ultimately promotes the process that marks FTO for degradation. In animal models, treatment with VES resulted in reduced tumor size and a significant improvement in the immune response against tumors, suggesting a promising avenue for enhancing cancer treatment strategies.
Furthermore, reducing FTO levels increased the methylation of a specific gene, LIF, involved in regulating immune responses, which allowed melanoma cells to become more susceptible to T cell attacks. Overall, these findings shed light on how VES not only degrades FTO but also holds the potential to improve outcomes for patients undergoing cancer therapies.
When VES binds to both FTO and an associated protein called DTX2, it boosts the interaction between them. This ultimately promotes the process that marks FTO for degradation. In animal models, treatment with VES resulted in reduced tumor size and a significant improvement in the immune response against tumors, suggesting a promising avenue for enhancing cancer treatment strategies.
Furthermore, reducing FTO levels increased the methylation of a specific gene, LIF, involved in regulating immune responses, which allowed melanoma cells to become more susceptible to T cell attacks. Overall, these findings shed light on how VES not only degrades FTO but also holds the potential to improve outcomes for patients undergoing cancer therapies.
7
We explored the relationship between dietary intake and the incidence of digestive system cancers, focusing specifically on vitamin E's impact. The study comprised a vast group of over 30,000 adults, gathered through the National Health and Nutrition Examination Survey, covering ten years of data from 2007 to 2018. Interestingly, our findings suggested that vitamin E intake negatively related to the development of hepatocellular carcinoma, a type of liver cancer.
While these results indicate a potentially protective effect of vitamin E concerning this specific cancer type, it’s important to note that the overall associations with other types of digestive cancers were less clear. We found no remarkable correlations between vitamin E and other digestive cancers, emphasizing the complexity of dietary influences on cancer risks. More research is essential to fully untangle these relationships and validate our findings further.
While these results indicate a potentially protective effect of vitamin E concerning this specific cancer type, it’s important to note that the overall associations with other types of digestive cancers were less clear. We found no remarkable correlations between vitamin E and other digestive cancers, emphasizing the complexity of dietary influences on cancer risks. More research is essential to fully untangle these relationships and validate our findings further.
9
Vitamin E enhances cancer treatment
In our exploration of breast cancer treatments, we investigated how nanoparticles infused with vitamin E could effectively deliver cancer medications. Our study specifically focused on drug-resistant HER2-positive breast cancer, which is challenging to treat due to its tendency to develop resistance to standard therapies.
We developed nanoparticles from human serum albumin linked with vitamin E, designed to encapsulate and deliver targeted cancer drugs. Through sophisticated methods, including infrared spectroscopy and cell viability assays, we confirmed that the nanoparticles efficiently bound the drugs and released them over time.
Our results revealed that combining these vitamin E-laden nanoparticles—specifically Lapatinib and Letrozole—in a carefully designed ratio led to a substantial reduction in tumor growth. This combination not only outperformed individual treatments but also proved effective in drug-resistant cell lines, showcasing the potential of vitamin E as a vehicle for enhancing cancer therapy.
Overall, while the study highlighted the promising role of vitamin E in this innovative drug delivery approach, it primarily emphasized the combined effects of the therapies rather than isolating vitamin E's impact alone.
We developed nanoparticles from human serum albumin linked with vitamin E, designed to encapsulate and deliver targeted cancer drugs. Through sophisticated methods, including infrared spectroscopy and cell viability assays, we confirmed that the nanoparticles efficiently bound the drugs and released them over time.
Our results revealed that combining these vitamin E-laden nanoparticles—specifically Lapatinib and Letrozole—in a carefully designed ratio led to a substantial reduction in tumor growth. This combination not only outperformed individual treatments but also proved effective in drug-resistant cell lines, showcasing the potential of vitamin E as a vehicle for enhancing cancer therapy.
Overall, while the study highlighted the promising role of vitamin E in this innovative drug delivery approach, it primarily emphasized the combined effects of the therapies rather than isolating vitamin E's impact alone.
References
- Zhong Y, Zhang R, Lu L, Tan H, You Y, et al. Specific sDMA modifications on the RGG/RG motif of METTL14 regulate its function in AML. Cell Commun Signal. 2025;23:126. doi:10.1186/s12964-025-02130-1
- Lee GA, Hsu JB, Chang YW, Hsieh LC, Li YT, et al. IL-19 as a promising theranostic target to reprogram the glioblastoma immunosuppressive microenvironment. J Biomed Sci. 2025;32:34. doi:10.1186/s12929-025-01126-w
- Abo-Kamer AM, Abdelaziz AA, Elkotb ES, Al-Madboly LA. Production and characterization of a promising microbial-derived lipase enzyme targeting BCL-2 gene expression in hepatocellular carcinoma. Microb Cell Fact. 2025;24:58. doi:10.1186/s12934-025-02671-7
- Shu C, Li J, Rui J, Fan D, Niu Q, et al. Uncovering the rewired IAP-JAK regulatory axis as an immune-dependent vulnerability of LKB1-mutant lung cancer. Nat Commun. 2025;16:2324. doi:10.1038/s41467-025-57297-5
- Xiong A, Wang L, Chen J, Wu L, Liu B, et al. Ivonescimab versus pembrolizumab for PD-L1-positive non-small cell lung cancer (HARMONi-2): a randomised, double-blind, phase 3 study in China. Lancet. 2025;405:839. doi:10.1016/S0140-6736(24)02722-3
- Zhang T, Wang B, Wei Y, Gan H, Fang B, et al. Neoadjuvant fuzuloparib combined with abiraterone for localized high-risk prostate cancer (FAST-PC): A single-arm phase 2 study. Cell Rep Med. 2025. doi:10.1016/j.xcrm.2025.102018
- Niu Y, Liu C, Jia L, Zhao F, Wang Y, et al. STX1A regulates ferroptosis and chemoresistance in gastric cancer through mitochondrial function modulation. Hum Cell. 2025;38:66. doi:10.1007/s13577-025-01195-x
- Wang X, Li T, Slebos RJC, Chaudhary R, Guevara-Patino JA, et al. Clinical significance of peripheral T-cell repertoire in head and neck squamous cell carcinoma treated with cetuximab and nivolumab. Cancer Immunol Immunother. 2025;74:142. doi:10.1007/s00262-025-03993-6
- Liu W, Li H, Botos I, Kumkhaek C, Zhu J, et al. Olfactomedin 4 promotes gastric cancer cell G2/M progression and serves as a therapeutic target in gastric adenocarcinoma. Carcinogenesis. 2025. doi:10.1093/carcin/bgaf010
- Es-Sai B, Wahnou H, Benayad S, Rabbaa S, Laaziouez Y, et al. Gamma-Tocopherol: A Comprehensive Review of Its Antioxidant, Anti-Inflammatory, and Anticancer Properties. Molecules. 2025;30. doi:10.3390/molecules30030653
- Qin X, Ge L, Wu S, Li W. Association of dietary intake with cancer of the digestive system: a cross-sectional study. Front Nutr. 2025;12:1539401. doi:10.3389/fnut.2025.1539401
- Shan X, Cai Y, Zhu B, Sun X, Zhou L, et al. Computer-Aided Design of Self-Assembled Nanoparticles to Enhance Cancer Chemoimmunotherapy via Dual-Modulation Strategy. Adv Healthc Mater. 2025. doi:10.1002/adhm.202404261
- Kadhim AH, El Arbi M, Muhammed HA. Vitamin E improves the reproductive system of male rats exposed to busulfan chemotherapy. Cell Mol Biol (Noisy-le-grand). 2025;70:175. doi:10.14715/cmb/2024.70.12.24
- Palencia-Campos A, Ruiz-Cañas L, Abal-Sanisidro M, López-Gil JC, Batres-Ramos S, et al. Reprogramming tumor-associated macrophages with lipid nanosystems reduces PDAC tumor burden and liver metastasis. J Nanobiotechnology. 2024;22:795. doi:10.1186/s12951-024-03010-5
- Cheng X, Cheng L, He J, Wang Y, Lin X, et al. The Mediating Role of Oxidative Stress on the Association Between Oxidative Balance Score and Cancer-Related Cognitive Impairment in Lung Cancer Patients: A Cross-Sectional Study. Nutrients. 2024;16. doi:10.3390/nu16234090
- Cui YH, Wei J, Fan H, Li W, Zhao L, et al. Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity. Proc Natl Acad Sci U S A. 2024;121:e2407910121. doi:10.1073/pnas.2407910121
- Zhang W, Song L, Zhou Y, Sun J, Li C, et al. Study on the inhibition of non-small cell lung cancer mediated by chitosan-based gene carrier delivering STAT3-shRNA. Int J Biol Macromol. 2025;284:138211. doi:10.1016/j.ijbiomac.2024.138211
- Are V, Das S, P S S, Biswas S. Combination therapy of Lapatinib/Letrozole-based protein-vitamin nanoparticles to enhance the therapeutic effectiveness in drug-resistant breast cancer. Colloids Surf B Biointerfaces. 2025;247:114399. doi:10.1016/j.colsurfb.2024.114399
- Wen XY, Cao MM, Zhang ZY, Xie N, Wei ZY, et al. [The role of endoplasmic reticulum IP(3)R calcium channel in vitamin E succinate induced autophagy of human gastric cancer cell]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2025;43:180. doi:10.3760/cma.j.cn121094-20240125-00037
- Satapathy D, Dutta TK, Chatterjee A, Yadav SK, Dutta S, et al. Ameliorating arsenic toxicity in young goats: assessing vitamin E and Saccharomyces cerevisiae on feed intake, carcass quality, mineral profiles in tissues and impending health risks to humans. Environ Geochem Health. 2025;47:141. doi:10.1007/s10653-025-02439-3
- Paganini V, Cesari A, Tampucci S, Chetoni P, Burgalassi S, et al. Nanostructured Strategies for Melanoma Treatment-Part I: Design and Optimization of Curcumin-Loaded Micelles for Enhanced Anticancer Activity. Pharmaceuticals (Basel). 2025;18. doi:10.3390/ph18030327
- Onali T, Slabá H, Jian C, Koivumäki T, Päivärinta E, et al. Berry supplementation in healthy volunteers modulates gut microbiota, increases fecal polyphenol metabolites and reduces viability of colon cancer cells exposed to fecal water- a randomized controlled trial. J Nutr Biochem. 2025. doi:10.1016/j.jnutbio.2025.109906
- Falsetti I, Palmini G, Zonefrati R, Vasa K, Donati S, et al. Antiproliferative Role of Natural and Semi-Synthetic Tocopherols on Colorectal Cancer Cells Overexpressing the Estrogen Receptor β. Int J Mol Sci. 2025;26. doi:10.3390/ijms26052305
