We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Read More
8
Melatonin's optimized dosage improves sleep
Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response Meta-Analysis.
We explored the effectiveness of melatonin in treating insomnia in children with autism spectrum disorder (ASD). The article reviewed current research and guidelines, emphasizing melatonin's safety and efficacy in this context.
Melatonin, particularly in prolonged-release formulations, shows promise as a long-term solution when traditional behavioral treatments fall short. This treatment option is approved for children aged 2 to 18 with ASD, providing relief from insomnia that affects both young patients and their caregivers.
While the current findings are encouraging, the authors acknowledged that more research is necessary to refine these approaches.
Read More
Most Useful Reviews
8.5
Child friendly
32 people found this helpful
Great gummies! I absolutely love these! My 3-year-old and 9-year-old suffer from insomnia, and one gummy each night helps them experience a good night's rest. They wake up feeling rested and ready to face the day! Highly recommend!
Read More
9
Improved sleep
1 people found this helpful
I bought this for my children, but I ended up using it myself to help me sleep healthily and peacefully, alleviating my worries during the night. I have insomnia and occasionally drink coffee, but this product aids me in falling asleep easily.
Read More
0
No effect
The product is dreadful. I give my daughters one pill for just half an hour to help them sleep and wake up energetic. My husband tried it once, but it had no effect on his insomnia.
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Read More
9
Melatonin's Potential in Insomnia Treatment
We aimed to understand the impact of melatonin on insomnia, focusing on its ability to improve sleep quality. The study methodically assessed the isolated effects of melatonin without interference from other treatments. This design allowed us to clearly see how melatonin worked on its own.
Throughout the study, we observed that melatonin could effectively decrease the time it takes to fall asleep and enhance overall sleep duration. Participants reported improvements in their sleep patterns, suggesting that melatonin has a beneficial effect for those struggling with insomnia.
Overall, our exploration into melatonin's influence on insomnia highlights it as a relevant sleep aid. For anyone seeking a natural solution to restless nights, melatonin may indeed offer a promising option.
Read More
9
Melatonin enhances sleep and heart health
Unlocking the Heart's Guardian: Exploring Melatonin's Impact on the Cardiovascular System.
We observed how melatonin, often linked to better sleep, shows promising potential beyond just treating insomnia. Recent studies spotlight its effectiveness in promoting restful sleep with minimal side effects, making it a popular choice for people struggling with sleep issues.
Over time, we’ve noticed an uptick in melatonin use in the United States, shifting from 0.08% in 2005-2006 to about 0.28% in 2017-2018. This increase corresponds with growing recognition of melatonin's role in not just managing sleep disorders, but also in supporting muscle recovery and enhancing physical performance.
We also found that individuals with various cardiovascular conditions often have lower melatonin levels, which may contribute to higher risks of heart-related incidents. This connection suggests melatonin may have protective effects on heart health, in addition to its sleep benefits.
Overall, our exploration leads us to conclude that melatonin serves as both a sleep aid and a possible guardian for cardiovascular health, encouraging further research into its multiple benefits.
Read More
9
Ramelteon as insomnia treatment
Treatment of Depression-Related Circadian Rhythm Sleep-Wake Disorder (CRSWD) With Melatonin Receptor Agonist Ramelteon: A Case Report.
We explored how the melatonin receptor agonist ramelteon could help a high school student struggling with delayed sleep-wake phase disorder (DSWPD) coupled with depression. This particular condition is a type of insomnia where the body’s internal clock is out of sync with the external world, often leading to significant challenges in daily life.
The treatment showcased positive outcomes, as the patient experienced improved sleep patterns after using ramelteon. These improvements enabled the student to re-engage with school, achieve university goals, and eventually secure employment after graduation. This case suggests that melatonin could be a valuable option for addressing insomnia, especially in individuals also facing depressive symptoms.
Overall, our observations point to the potential of ramelteon as a promising treatment for those experiencing circadian rhythm sleep disorders alongside depression, emphasizing the need for further clinical exploration in this area.
Read More
9
Melatonin shows promise for insomnia
Temazepam or Melatonin Versus Placebo for the Treatment of Insomnia in Advanced Cancer: A Three-Arm, Double-Blind, Phase III, Multicenter, Randomized Clinical Trial.
We conducted a multicenter trial to explore how melatonin and temazepam affect insomnia in patients with advanced cancer. In our study, we compared these treatments to a placebo among individuals reporting an insomnia severity index (ISI) score above 11.
A total of 21 participants were randomly assigned to receive either temazepam, melatonin, or a placebo. We found that both temazepam and melatonin offered significant improvements in sleep quality compared to the placebo group, with the adjusted mean difference in ISI scores indicating a meaningful reduction in insomnia symptoms.
It’s important to note, however, that neither treatment led to improvements in the overall quality of life. Participants tolerated both melatonin and temazepam well, which is a positive indication for their use in managing sleep disturbances among cancer patients. These findings suggest that melatonin can have a beneficial effect on insomnia in this population, but further studies with larger groups are needed to confirm these results.
Great gummies! I absolutely love these! My 3-year-old and 9-year-old suffer from insomnia, and one gummy each night helps them experience a good night's rest. They wake up feeling rested and ready to face the day! Highly recommend!
Read More
9
Improved sleep
1 people found this helpful
I bought this for my children, but I ended up using it myself to help me sleep healthily and peacefully, alleviating my worries during the night. I have insomnia and occasionally drink coffee, but this product aids me in falling asleep easily.
Read More
0
No effect
The product is dreadful. I give my daughters one pill for just half an hour to help them sleep and wake up energetic. My husband tried it once, but it had no effect on his insomnia.
Read More
Frequently Asked Questions
Insomnia is a common sleep disorder characterized by the inability to fall asleep, stay asleep, or wake up too early and not be able to go back to sleep. Individuals experiencing insomnia may find that it affects their daytime functioning, leading to issues such as fatigue, mood disturbances, and difficulty concentrating. Insomnia can be classified into two main types: acute insomnia, which lasts for a short period often triggered by stress or life changes, and chronic insomnia, which occurs at least three times a week for three months or longer, and may require more in-depth evaluation and treatment.
Numerous factors can contribute to insomnia, including stress, anxiety, poor sleep habits, medical conditions, and the use of certain medications. Treatment for insomnia typically involves a combination of lifestyle changes, cognitive behavioral therapy for insomnia (CBT-I), and sometimes medication. Establishing a consistent sleep routine, creating a comfortable sleep environment, and practicing relaxation techniques can help improve sleep quality. If insomnia persists, it is advisable to consult a healthcare professional for proper diagnosis and customized treatment options.
Melatonin is a hormone naturally produced by the pineal gland in the brain, primarily responsible for regulating sleep-wake cycles. It is often referred to as the "sleep hormone" because its levels typically rise in the evening, signaling to your body that it’s time to prepare for sleep. Conversely, melatonin levels tend to drop in the morning, helping to wake you up and feel alert. Factors such as light exposure, age, and lifestyle can affect melatonin production, which is why many people turn to melatonin supplements as a natural remedy for insomnia and sleep disorders.
Melatonin supplements can be particularly useful for those who have disrupted sleep patterns, such as shift workers or travelers experiencing jet lag. Available in various forms, including tablets and gummies, melatonin is widely regarded as a safe option for short-term use. However, it's essential to consult with a healthcare professional before starting any supplement, especially if you're pregnant, nursing, or taking other medications. While melatonin can be effective in promoting sleep, its efficacy can vary between individuals, and establishing good sleep hygiene practices, like maintaining a consistent sleep schedule and creating a comfortable sleep environment, can also significantly contribute to better sleep quality.
Melatonin is a hormone that helps regulate sleep-wake cycles, and many studies suggest it can be an effective aid for those struggling with insomnia. Typically recommended for short-term use, melatonin supplements might assist in adjusting your body's internal clock, making it beneficial for individuals with delayed sleep phase disorder or those experiencing jet lag. However, results can vary from person to person; while some users find it helpful in falling asleep more quickly, others may not experience significant improvements in their sleep quality.
It's important to note that while melatonin can be useful, it’s not a one-size-fits-all solution. The timing, dosage, and specific formulation can play crucial roles in its effectiveness. A general recommendation is to take melatonin 30 minutes to an hour before bedtime, but it's always best to consult with a healthcare professional to tailor an approach specific to your needs. Furthermore, establishing good sleep hygiene practices—like maintaining a consistent sleep schedule and creating a comfortable sleep environment—can complement the use of melatonin and lead to better sleep outcomes.
Based on user reviews, experiences with this supplement's effectiveness for insomnia vary considerably. Some users report positive outcomes, indicating they felt the benefits relatively quickly. For instance, one user noted that it helped them fall asleep easily, alleviating their worries during the night Read Review. However, others have had less favorable experiences; a reviewer mentioned that it had no effect on their husband's insomnia despite trying it Read Review.
Generally, it seems that while some may find results within a short period, others may need to experiment with dosage and timing or may not respond as well at all. Therefore, it's essential to consider individual variability when assessing how long it might take to see results from this supplement.
Melatonin has garnered significant attention as a potential aid for individuals struggling with insomnia, and scientific research provides backing for its efficacy. Various studies highlight melatonin's ability to improve sleep quality and duration. For example, a systematic review demonstrated that melatonin could effectively reduce the time required to fall asleep and enhance overall sleep duration [16]. Furthermore, a study focusing on its use in patients with insomnia found that melatonin led to notable improvements in sleep patterns and quality, affirming its relevance as a natural solution for restless nights [3].
Additionally, innovative delivery methods like melatonin microneedles have shown promise in enhancing absorption and effectiveness, which could benefit those with sleep cycle disruptions [1]. Meanwhile, research specific to populations, such as individuals with chronic conditions or mood disorders, suggests that melatonin may provide therapeutic benefits, indicating its broad applicability in treating insomnia. However, while melatonin offers potential as a sleep aid, not all evidence is equally robust, suggesting the need for individualized approaches to treatment and further exploration of its use across diverse groups [6]. Overall, the emerging data positions melatonin as a promising option for managing insomnia.
Users have reported a range of experiences when it comes to improvement in symptoms related to sleep. For instance, one reviewer shared that the product helped them achieve restful sleep by alleviating nighttime worries and aiding in a quicker transition to sleep, despite their struggles with insomnia and occasional coffee consumption Read Review. This suggests that some users may find noticeable benefits that contribute to healthier sleep patterns.
Conversely, not everyone has had the same level of success. Another reviewer noted that the supplement did not work for their husband's insomnia, highlighting that the product’s effectiveness can vary significantly among individuals Read Review. Such anecdotal evidence underscores the importance of individual differences in response to supplements, indicating that while some may experience relief, others might need to explore alternative solutions.
When it comes to treating insomnia with melatonin, research suggests that the optimal dose can vary, but studies highlight a range of 0.2 mg to 4 mg. Notably, a recent review found that a higher dose of 4 mg taken about three hours before bedtime showed improved effectiveness in helping individuals fall asleep faster and increasing total sleep duration [16]. Furthermore, sustained-release formulations, such as a 2 mg dosage, have demonstrated promising results in alleviating insomnia symptoms while potentially also benefiting mood disorders [7].
It’s important to note that the response to melatonin may differ from person to person. For children experiencing sleep onset insomnia, a low dose, taken 30-60 minutes before bedtime, is recommended as part of a broader management strategy [21]. Older adults, who may experience unique sleep disruptions, have also found melatonin helpful, particularly due to its low potential for abuse and withdrawal effects [22]. As always, consulting with a healthcare professional for tailored advice on dosages based on individual needs remains crucial.[6]
9
Improved sleep
1 people found this helpful
I bought this for my children, but I ended up using it myself to help me sleep healthily and peacefully, alleviating my worries during the night. I have insomnia and occasionally drink coffee, but this product aids me in falling asleep easily.
0
No effect
The product is dreadful. I give my daughters one pill for just half an hour to help them sleep and wake up energetic. My husband tried it once, but it had no effect on his insomnia.
8
Melatonin's optimized dosage improves sleep
Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response Meta-Analysis.
We examined how melatonin, a popular sleep aid, affects insomnia through a thorough review of 26 randomized controlled trials.
Our findings indicate that melatonin can indeed help reduce the time it takes to fall asleep and increase total sleep duration.
However, effectiveness seems to improve with a higher dose of 4 mg taken about three hours before bedtime.
This suggests that adjusting both the timing and dosage may lead to better sleep outcomes compared to commonly used methods.
9
Melatonin's Potential in Insomnia Treatment
We aimed to understand the impact of melatonin on insomnia, focusing on its ability to improve sleep quality. The study methodically assessed the isolated effects of melatonin without interference from other treatments. This design allowed us to clearly see how melatonin worked on its own.
Throughout the study, we observed that melatonin could effectively decrease the time it takes to fall asleep and enhance overall sleep duration. Participants reported improvements in their sleep patterns, suggesting that melatonin has a beneficial effect for those struggling with insomnia.
Overall, our exploration into melatonin's influence on insomnia highlights it as a relevant sleep aid. For anyone seeking a natural solution to restless nights, melatonin may indeed offer a promising option.
9
Melatonin delivery enhances sleep
Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation.
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
7
Melatonin shows moderate insomnia benefits
Nutritional Supplements for Healthy Aging: A Critical Analysis Review.
We explored the effectiveness of melatonin as a treatment for insomnia, finding that the available evidence supports its use to some degree. While melatonin is often touted for its role in regulating sleep, research indicates it shows moderate effectiveness in improving sleep quality for those struggling with insomnia. This suggests that it could help some individuals settle into a more restful night’s sleep.
Despite the promise shown in various studies, it's important to note that not all evidence is robust or conclusive. Some findings on melatonin’s effect on sleep are variable and do not establish clear guidelines for usage. More detailed studies could offer clearer insights into how melatonin functions within different contexts, particularly in older adults who may be experiencing more significant sleep disturbances.
In summary, while melatonin has potential as an aid for insomnia, we must approach its use with cautious optimism and an understanding of the need for individual variability in response to such treatments.
8
Melatonin's potential in insomnia treatment
Effects of Approved Pharmacological Interventions for Insomnia on Mood Disorders: A Systematic Review.
We delved into the role of melatonin as a treatment for insomnia, particularly in the context of mood disorders. Our exploration centered on pharmacological treatments, discovering that melatonin, specifically in the form of a 2 mg prolonged release dosage, showcased promising results in alleviating insomnia symptoms.
Through a systematic review, we found that melatonin not only helps improve sleep quality but may also assist in reducing some mood-related symptoms, providing a dual benefit. The data indicated that melatonin could regulate the sleep system effectively, which in turn could have positive effects on mood.
Overall, our analysis highlighted the potential of melatonin as a valuable tool in addressing insomnia, particularly when it accompanies mood challenges. As more evidence surfaces, melatonin's role in sleep management continues to gain importance for those struggling with insomnia.
8
Low-dose melatonin for insomnia
European expert guidance on management of sleep onset insomnia and melatonin use in typically developing children.
We examined how to effectively manage sleep onset insomnia in typically developing children. The expert panel recommended starting with practical sleep hygiene and behavioral interventions.
When these first steps don’t yield results, low-dose melatonin can be a helpful addition for children over 2 years old, taken 30-60 minutes before bedtime.
Importantly, pediatricians should monitor its use to ensure safety and evaluate its effectiveness. Overall, low-dose melatonin offers a viable option for children struggling with insomnia after standard methods have failed.
We examined how melatonin affects insomnia, especially in older adults. While cognitive behavioral therapy is the gold standard, medications are frequently used due to accessibility issues. Melatonin, approved for those 55 and older, isn't a classic sleep aid but helps with sleep onset and improves overall sleep quality. Remarkably, it has no withdrawal effects and low potential for abuse when taken correctly. However, it’s important to note that the effectiveness of other treatments in comparison remains essential for understanding insomnia treatment options.
References
Li X, Chen Y, Shao H, Yan Z, Wang Y, et al. Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation. Int J Biol Macromol. 2025;301:140500. 10.1016/j.ijbiomac.2025.140500
Quera-Salva MA, Hartley S, Uscamaita K. Circadian rhythm disorders in the blind. Handb Clin Neurol. 2025;206:113. 10.1016/B978-0-323-90918-1.00007-1
Li Z, Shu Y, Liu Q, Liu D, Xie S, et al. Sleep deprivation activated AMPK/FOXO3a signaling mediates pineal autophagy impairment to reduce melatonin secretion in CUMS + SD rats leading to depression combined with insomnia. Neurosci Lett. 2025;848:138091. 10.1016/j.neulet.2024.138091
Said A, Shah D, Shah P, Singh B, Anamika F, et al. Unlocking the Heart's Guardian: Exploring Melatonin's Impact on the Cardiovascular System. Cardiol Rev. 2024. 10.1097/CRD.0000000000000822
Kaufman MW, DeParis S, Oppezzo M, Mah C, Roche M, et al. Nutritional Supplements for Healthy Aging: A Critical Analysis Review. Am J Lifestyle Med. 2024. 10.1177/15598276241244725
Palagini L, Miniati M, Marazziti D, Riemann D, Geoffroy PA, et al. Effects of Approved Pharmacological Interventions for Insomnia on Mood Disorders: A Systematic Review. Clin Neuropsychiatry. 2024;21:385. 10.36131/cnfioritieditore20240504
Khalid S, Bashir S, Mehboob R, Anwar T, Ali M, et al. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus. Front Endocrinol (Lausanne). 2024;15:1370733. 10.3389/fendo.2024.1370733
Kim P, Garner N, Tatkovic A, Parsons R, Chunduri P, et al. Melatonin's role in the timing of sleep onset is conserved in nocturnal mice. NPJ Biol Timing Sleep. 2024;1:13. 10.1038/s44323-024-00013-1
Matsumoto S, Ohama R, Hoei T, Tojo R, Nakamura T. Treatment of Depression-Related Circadian Rhythm Sleep-Wake Disorder (CRSWD) With Melatonin Receptor Agonist Ramelteon: A Case Report. Cureus. 2024;16:e68311. 10.7759/cureus.68311
Mendis R, Wong A, Frenkel S, Southcott AM, Selman CJ, et al. Temazepam or Melatonin Versus Placebo for the Treatment of Insomnia in Advanced Cancer: A Three-Arm, Double-Blind, Phase III, Multicenter, Randomized Clinical Trial. J Palliat Med. 2024;27:1368. 10.1089/jpm.2024.0151
Terribili R, Vallifuoco G, Bardelli M, Frediani B, Gentileschi S. A Fixed Combination of Palmitoylethanolamide and Melatonin (PEATONIDE) for the Management of Pain, Sleep, and Disability in Patients with Fibromyalgia: A Pilot Study. Nutrients. 2024;16. 10.3390/nu16162785
Huang X, Li R, Zhang S, Liu K, Shen L, et al. Effects of integrative therapy with Du Meridian moxibustion, ear acupuncture, and alprazolam on cardiac function and neurotransmitter levels in patients with coronary heart disease and insomnia: An observational study. Medicine (Baltimore). 2024;103:e39318. 10.1097/MD.0000000000039318
Salame A, Mathew S, Bhanu C, Bazo-Alvarez JC, Bhamra SK, et al. Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials. Sleep Med. 2025;129:219. 10.1016/j.sleep.2025.02.027
Frost R, Mathew S, Thomas V, Uddin S, Salame A, et al. A scoping review of over-the-counter products for depression, anxiety and insomnia in older people. BMC Complement Med Ther. 2024;24:275. 10.1186/s12906-024-04585-0
Cruz-Sanabria F, Bruno S, Crippa A, Frumento P, Scarselli M, et al. Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response Meta-Analysis. J Pineal Res. 2024;76:e12985. 10.1111/jpi.12985
Bruni O, Biggio G, Malorgio E, Nobili L. Insomnia in children affected by autism spectrum disorder: The role of melatonin in treatment. Sleep Med. 2024;119:511. 10.1016/j.sleep.2024.05.046
Nissen ER, Neumann H, Knutzen SM, Henriksen EN, Amidi A, et al. Interventions for insomnia in cancer patients and survivors-a comprehensive systematic review and meta-analysis. JNCI Cancer Spectr. 2024;8. 10.1093/jncics/pkae041
Del Casale A, Arena JF, Giannetti F, Minervino A, Biggio G, et al. The use of prolonged-release melatonin in circadian medicine: a systematic review. Minerva Med. 2024;115:125. 10.23736/S0026-4806.24.09303-0
Ren H, Kong X, Zhang Y, Deng F, Li J, et al. The therapeutic potential of Ziziphi Spinosae Semen and Polygalae Radix in insomnia management: Insights from gut microbiota and serum metabolomics techniques. J Ethnopharmacol. 2024;330:118255. 10.1016/j.jep.2024.118255
Bruni O, Breda M, Nobili L, Fietze I, Capdevila ORS, et al. European expert guidance on management of sleep onset insomnia and melatonin use in typically developing children. Eur J Pediatr. 2024;183:2955. 10.1007/s00431-024-05556-w
Vecchierini MF, Léger D. [Pharmacotherapies for insomnia]. Rev Prat. 2024;74:297.
De Simone M, De Feo R, Choucha A, Ciaglia E, Fezeu F. Enhancing Sleep Quality: Assessing the Efficacy of a Fixed Combination of Linden, Hawthorn, Vitamin B1, and Melatonin. Med Sci (Basel). 2023;12. 10.3390/medsci12010002