Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
667 mcg DFE (400 mcg Folic Acid)
167%
Calcium (as Calcium Carbonate)
100 mg
8%
The product is found useful for the following medical conditions
Flu details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 12 Reviews
9
10
Flu prevention success
Most Useful Review
Excellent! I'm thrilled to have discovered this. I've taken it daily for about six months now and haven't experienced a cold or flu throughout winter. My mood has vastly improved, and I'm much happier these days. It has significantly benefited my overall health, making my immune system stronger than ever, and it’s easy on the stomach.
Allergies details
SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5.5
USERS' SCORE
Good
Based on 12 Reviews
8.8
7
Folic acid alleviates gastric hypersensitivity
We investigated how folic acid (FA) impacts gastric hypersensitivity caused by prenatal stress. Through a series of experiments involving nerve recordings and molecular analysis, we found that FA significantly alleviated symptoms related to gastric hypersensitivity.
It worked by boosting the expression of DNMT1, which in turn reduced the activity of ASIC1, a key molecule involved in pain sensation. While promising, further research is essential as this study primarily focuses on rats. The findings may pave the way for potential treatments in humans.
It worked by boosting the expression of DNMT1, which in turn reduced the activity of ASIC1, a key molecule involved in pain sensation. While promising, further research is essential as this study primarily focuses on rats. The findings may pave the way for potential treatments in humans.
8.8
Reduced allergy symptoms
Most Useful Review
Excellent! I feel much better taking this every day. I had quite severe allergies, but after starting it, my symptoms have diminished, and I've been sick less often. If you're seeking a way to improve your health, this is it!
Anxiety details
SCIENTIFIC SCORE
Possibly Effective
Based on 18 Researches
7.2
USERS' SCORE
Good
Based on 5 Reviews
8.8
9
We explored how folic acid (FA) given during pregnancy influences anxiety and cognitive issues in postpartum mice. By administering FA at different doses, we observed noteworthy improvements in anxiety and cognitive performance among the mice that received a higher dosage.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
Although overall development of the offspring was not marked by changes, the findings suggest that FA significantly activates brain pathways important for mood and memory. This points to potential benefits for postpartum women experiencing similar emotional challenges.
9.5
Healthier mood
Most Useful Review
I've been using this vitamin for six months, and it has honestly transformed my life. I can work longer hours and feel healthier overall. I’m not frequently ill now, which is crucial for workplace health. My mood has also vastly improved; I experience no more anxiety!
Common Cold details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 5 Reviews
8.8
8
We explored the effectiveness of a special combination of micronutrients, including folate, in helping patients who suffer from recurrent upper respiratory tract infections, commonly known as colds. Our study involved 192 participants over 16 weeks in a randomized, placebo-controlled, double-blind trial that allowed us to compare results objectively.
The findings indicate that patients who had vitamin D deficiency or were low in vitamin C experienced significant benefits when taking the micronutrient combination, and symptoms improved notably compared to those on a placebo. Specifically, individuals with multiple cold symptoms showed greater relief in the active group, with a significant reduction in symptom intensity.
While folate was part of the mix, the study did not isolate its specific impact on cold symptoms. Instead, it highlighted the effectiveness of the whole nutrient combination in reducing the frequency of colds and the intensity of symptoms. Overall, those who received the micronutrient supplement reported improved health outcomes compared to those who didn't.
The findings indicate that patients who had vitamin D deficiency or were low in vitamin C experienced significant benefits when taking the micronutrient combination, and symptoms improved notably compared to those on a placebo. Specifically, individuals with multiple cold symptoms showed greater relief in the active group, with a significant reduction in symptom intensity.
While folate was part of the mix, the study did not isolate its specific impact on cold symptoms. Instead, it highlighted the effectiveness of the whole nutrient combination in reducing the frequency of colds and the intensity of symptoms. Overall, those who received the micronutrient supplement reported improved health outcomes compared to those who didn't.
9.5
Improved immunity
Most Useful Review
Excellent! I have been taking these vitamins for a few weeks now and feel like I’m embarking on something new. I no longer feel tired or in pain, and my mood has significantly improved! I’ve even noticed that I’m less prone to catching a common cold than before. These vitamins are fantastic!
Anemia details
SCIENTIFIC SCORE
Questionable
Based on 27 Researches
6.9
USERS' SCORE
Good
Based on 28 Reviews
8.7
9.5
Family education improves anemia treatment
We investigated how family-centered health education influences adherence to iron-folic acid supplements and improves anemia among pregnant women. Through a quasi-experimental trial, we compared results from intervention and control groups, focusing on women aged 14-16 weeks with anemia.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
Our findings showed that this educational approach led to notable increases in participants' knowledge and practices regarding anemia management. Significant drops in moderate and mild anemia rates were observed, along with improvements in hemoglobin and ferritin levels. This suggests that better education can effectively enhance anemia status in expectant mothers.
9.5
Organised menstruation
Most Useful Review
I am a young woman and found this product beneficial for my long hair and nails while addressing anemia. I experienced palpitations and heart discomfort, but after taking these pills, I no longer do. Constipation issues also improved, and my period became regular, arriving on time with no pain. I took one pill daily for two months, noticing great results. The bottle was substantial, reasonably priced, and the small pills were easy to swallow. Drink plenty of water while taking folic acid for the best results.
Depression details
SCIENTIFIC SCORE
Possibly Effective
Based on 21 Researches
7.1
USERS' SCORE
Good
Based on 6 Reviews
8.7
9
We examined the effects of folic acid as an add-on treatment for major depression alongside traditional medications like SSRIs and SNRIs. After reviewing six randomized control trials, we found that patients receiving folic acid showed better progress.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
Specifically, their depression scores improved significantly, with higher response and remission rates as well. This suggests that adding folic acid might enhance the benefits of standard depression therapies, giving hope to those looking for more effective treatment options.
8.8
Better well-being
Most Useful Review
I take folic acid to combat my depression. My well-being and mood have steadily improved. I appreciate the results, especially as I had previously lost hope that anything would help me.
Dizziness details
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.3
USERS' SCORE
Good
Based on 6 Reviews
8.7
9
Folate alleviates dizziness symptoms
We explored the effectiveness of L-methylfolate, a form of folate, on alleviating dizziness, particularly in individuals with a specific genetic mutation. In one case, a patient experienced prolonged symptoms like headache, fatigue, and dizziness after taking terbinafine, known as Lamisil.
After conducting genetic tests, it was discovered that this patient was heterozygous for the C677T variation of the methylenetetrahydrofolate reductase (MTHFR) gene, which can affect how the body processes folate.
Fortunately, after prescribing L-methylfolate (Deplin), the patient's symptoms significantly improved. This reinforces the potential of L-methylfolate to help individuals with certain genetic predispositions, especially when medications interfere with the body's methylation cycle.
Overall, our findings suggest that for some patients, especially those with MTHFR mutations, treating dizziness with folate could be a promising avenue worth exploring further.
After conducting genetic tests, it was discovered that this patient was heterozygous for the C677T variation of the methylenetetrahydrofolate reductase (MTHFR) gene, which can affect how the body processes folate.
Fortunately, after prescribing L-methylfolate (Deplin), the patient's symptoms significantly improved. This reinforces the potential of L-methylfolate to help individuals with certain genetic predispositions, especially when medications interfere with the body's methylation cycle.
Overall, our findings suggest that for some patients, especially those with MTHFR mutations, treating dizziness with folate could be a promising avenue worth exploring further.
9.5
Dizziness disappeared
Most Useful Review
I purchased this product for my daughter, who received a large supply of 250 tablets. Each tablet contains 400 micrograms of folic acid, which is quite effective. After taking it for two months, her blood counts normalised, and her dizziness completely vanished.
Hair Loss details
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 56 Reviews
8.7
8
Folic acid treatment shows promise
We explored the effects of folic acid on hair loss in a three-week-old Charolais calf showing signs typical of folic acid deficiency. After starting daily folic acid therapy at a dose of 1 mg/kg, we observed that the crusts and patches diminished within two weeks. Remarkably, hair growth resumed, and within two months, the calf returned to a normal state. This indicates that folic acid could be an effective treatment for certain types of alopecia related to deficiencies in this essential nutrient.
8.3
Reduced hair loss
Most Useful Review
I opted to buy folic acid along with other elements like biotin and vitamins D and C due to my hair loss dilemma. It was devastating seeing strands fall during washing! I researched beneficial ingredients and found the price reasonable for the quantity. After using it, I've noticed a significant decrease in hair loss. Folic acid is particularly useful for women considering pregnancy, as it helps reduce congenital malformations. It's advised to take 400 micrograms, and consistency is key for lasting impact.
Menopause details
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7
USERS' SCORE
Good
Based on 8 Reviews
8.7
9
We explored the effectiveness of folic acid in alleviating menopausal hot flashes in a clinical trial involving 70 women. Participants were randomly assigned to receive either folic acid or a placebo for four weeks.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
Our findings showed that folic acid significantly reduced the severity, duration, and frequency of hot flashes compared to the placebo. With these positive results, folic acid emerges as an affordable and accessible alternative treatment for managing menopausal symptoms.
9.5
Supports menopause transition
Most Useful Review
Folic Acid is very good value for money! I take it regularly! It effectively restores all mucous tissues and aids in healing women's reproductive organs. While often associated only with pregnancy, this acid is also beneficial for experiencing menopause smoothly, both during and after it! After 40, it's absolutely essential for the female body. It also plays a role in cellular metabolism and boosts metabolic rate!
Rash details
SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Good
Based on 5 Reviews
8.7
7
We reviewed numerous studies to understand the skin reactions stemming from Methotrexate (MTX). Our analysis included data from over 8,000 papers, ultimately focusing on 31 relevant studies involving 38 patients.
Common skin issues included severe conditions like toxic epidermal necrolysis and erythema multiforme. While we found that immediate withdrawal of MTX and treatments, including folic acid supplementation, were beneficial, it's clear that healthcare providers must recognize these possible reactions to prevent severe consequences.
Common skin issues included severe conditions like toxic epidermal necrolysis and erythema multiforme. While we found that immediate withdrawal of MTX and treatments, including folic acid supplementation, were beneficial, it's clear that healthcare providers must recognize these possible reactions to prevent severe consequences.
9.5
Rash healed quickly
Most Useful Review
Excellent folic acid; the rash on my hands from the Russian folk remedy has disappeared! I’ve read numerous articles about the benefits of folic acid, particularly when planning a pregnancy. We don’t get enough from food alone, as it’s found in parsley, cabbage, cucumbers, and lentils, among others. Sadly, it breaks down during cooking! My doctor prescribed Foliber, 400mcg, three times a day for three months. Initially, a rash appeared on my hands, possibly an allergic reaction. Ignoring it, I completed the package and decided to try Folic Acid from 21 Century. After starting it, my hands healed gradually, and the rash did not return! Now, after two months, everything is fine!
Blood Clot details
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
We investigated how folic acid affects blood clotting, particularly when exposed to carbon black (CB), a common industrial substance. In our study with adult C57BL/6 mice, we found that prolonged exposure to CB led to increased blood clotting potential due to changes in the spleen, where extra blood cell production occurs.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
Notably, we observed that CB exposure caused an increase in certain cells responsible for blood clotting, while decreasing folic acid levels in the bloodstream. This drop in folic acid seemed to correlate with heightened levels of prostaglandin E2, a compound that can drive inflammation and increase blood clotting.
When we supplemented the mice with folic acid, we noted a reduction in the negative effects of CB on blood clotting. This protective effect appeared to stem from folic acid's ability to inhibit the enzymes involved in the excessive production of prostaglandins by splenic macrophages. Overall, our findings suggest that folic acid supplementation could be a valuable strategy to mitigate the heightened risk of thrombosis associated with carbon black exposure.
8.8
Improved blood flow
Most Useful Review
Folic acid is essential for supporting blood vessels and the heart. My gynecologist prescribed it after poor blood clot test results. These vitamins suited me; the size and dosage are convenient, and the quality is excellent. The packaging is practical, and the taste is neutral. I feel that my nervous system has improved, my metabolism has sped up, and I have plenty of energy.
Cardiovascular Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.4
USERS' SCORE
Good
Based on 21 Reviews
8.6
8
We examined the connection between folic acid levels and stroke risk in a study involving nearly 5,000 individuals from a Chinese community. We discovered that participants with higher folate levels had a significantly lower risk of experiencing strokes.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
Specifically, those in the highest folate group had a 32% lower risk of stroke compared to those with the lowest levels. We also found that homocysteine levels played a significant role in this relationship. Interestingly, the genetic variation of the MTHFR gene influenced how folate affected stroke risk, revealing a more complex interaction.
9.5
Improved hemoglobin levels
Most Useful Review
Folic acid aids in treating anaemia. I take it alongside iron supplements to improve my haemoglobin levels. Folic acid enhances iron absorption. It’s often mistakenly viewed as solely for pregnant women, but deficiency can occur in anyone, especially those with gastrointestinal issues. I've raised my haemoglobin to target levels without side effects.
Diabetes details
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.2
USERS' SCORE
Good
Based on 3 Reviews
8.6
7
We explored the connection between folate metabolites and diabetic kidney disease (DKD), a serious complication that affects around 40% of individuals with type 2 diabetes. Our investigation drew on data from a large U.S. survey spanning nearly a decade, from 2011 to 2020, focusing on various forms of folate to see how they relate to DKD.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
Through our research, we discovered that higher levels of total folate and 5-Methyl-THF were associated with a lower risk of DKD. Specifically, those in the highest quintile of these folate forms had an odds ratio (OR) of 0.73, indicating a protective effect. In contrast, certain other forms of folate, like RBC folate and UMFA, were linked to an increased risk of DKD, with ORs exceeding 1.4. This suggests that not all folate is beneficial when it comes to this condition.
Overall, our findings highlight the potential importance of promoting 5-Methyl-THF while minimizing UMFA for better diabetes management. It's clear that a balanced approach to folate intake could be crucial for maintaining kidney health in those with diabetes.
9
Improves diabetes control
Most Useful Review
Supplementing with folate-based supplements, including folic acid, may enhance heart health and mitigate your risk of heart disease factors. Furthermore, folic acid supplements can assist in lowering high blood pressure, a known risk for heart disease. They have been demonstrated to improve blood flow, which may subsequently enhance cardiovascular function. Folate-based supplements can aid in better blood sugar control, reduce insulin resistance, and boost cardiovascular function for those with diabetes. Additionally, these supplements might help lessen diabetic complications, such as neuropathy. I intend to give it a try!
Heart Disease details
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.6
USERS' SCORE
Good
Based on 36 Reviews
8.6
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.
The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.
Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
8.8
Affordability and quality
Most Useful Review
Folic acid is beneficial not only for women planning pregnancy but also for men, helping with heart health and immunity. It has an excellent price/quality ratio and lasts over a month, making it a wise investment in health, especially concerning heart disease.
Leg Cramps details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Cured leg cramps
Most Useful Review
Symptoms of anaemia, including leg cramps, left me feeling dizzy and fatigued, with pale skin and peeling nails. After a course of folic acid, my tests showed normal haemoglobin levels. This confirms to me that this vitamin is effective in treating leg cramps.
Polycystic Ovary Syndrome details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.6
9.5
Supports ovulation
Most Useful Review
This helps with ovulation, which women with Polycystic ovary syndrome often struggle with. You can't beat the price and dosage; I love this brand for the value it offers.
Nausea details
SCIENTIFIC SCORE
Questionable
Based on 4 Researches
6.3
USERS' SCORE
Good
Based on 9 Reviews
8.5
8
We explored the impact of folic acid combined with ferrous bisglycinate on nausea in pregnant women facing iron deficiency. In a controlled trial involving 120 participants, we discovered that the group taking ferrous bisglycinate with folinic acid reported significantly fewer instances of nausea and other discomforts compared to those receiving a standard iron supplement.
Both groups saw improvements in iron status and related blood markers over six months, but our findings clearly indicated that the test group had a more tolerable experience. Folic acid may play a vital role in making iron supplementation easier for pregnant women.
Both groups saw improvements in iron status and related blood markers over six months, but our findings clearly indicated that the test group had a more tolerable experience. Folic acid may play a vital role in making iron supplementation easier for pregnant women.
9.5
No nausea
Most Useful Review
Folic acid is crucial for anyone, especially those planning to have children. The package contains 250 easy-to-swallow tablets and has good tolerance, causing no nausea. It's an economical choice that prevents folic acid deficiency effectively.
Rheumatoid Arthritis details
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.8
USERS' SCORE
Good
Based on 2 Reviews
8.5
9
Folic acid-modified vesicles tackle RA
This study presents an innovative approach to tackling rheumatoid arthritis (RA) using folic acid-modified ginger-derived extracellular vesicles (FA-GDEVs). We explored how these tiny vesicles, enriched with bioactive compounds from ginger, can be directed toward inflamed joints by utilizing folic acid to target specific immune cells.
Initially, we investigated the ability of FA-GDEVs to shift the balance of macrophages from the harmful M1 type, which fuels inflammation, to the more healing M2 type. Our findings revealed that FA-GDEVs effectively influence this transition by activating related pathways within the cells.
In practical terms, this means that FA-GDEVs can not only find their way to affected areas more efficiently but also work to reduce signs of RA while maintaining a good safety profile. Ultimately, these ginger-derived vesicles could be a more affordable and safer option for RA treatment, marking a significant advancement in how we approach this chronic condition.
Initially, we investigated the ability of FA-GDEVs to shift the balance of macrophages from the harmful M1 type, which fuels inflammation, to the more healing M2 type. Our findings revealed that FA-GDEVs effectively influence this transition by activating related pathways within the cells.
In practical terms, this means that FA-GDEVs can not only find their way to affected areas more efficiently but also work to reduce signs of RA while maintaining a good safety profile. Ultimately, these ginger-derived vesicles could be a more affordable and safer option for RA treatment, marking a significant advancement in how we approach this chronic condition.
8.8
Reliable vitamins
Most Useful Review
The price and quality are fantastic. Great value for money! I find that taking this for a week aids in the treatment of my rheumatoid arthritis. I trust the vitamins from this company, as they offer better price and composition compared to those from pharmacies.
Back Pain details
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9
USERS' SCORE
Good
Based on 5 Reviews
8.4
9
We explored the effects of methotrexate (MTX), a well-known folic acid antagonist, in addressing epidural fibrosis (EF), a common complication that can lead to persistent back pain after lumbar surgery. In our study, we tested how topical application of MTX influenced the healing process following lumbar laminectomy in rats, an experimental model for understanding back pain post-surgery.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
Our results were promising—the use of MTX seemed to significantly suppress the development of EF compared to the control group. We measured this through various methods, including macroscopic scoring, hydroxyproline content analysis, and histological evaluations. Additionally, we observed that the effectiveness of MTX was dose-dependent, increasing with higher concentrations.
We also investigated the underlying mechanisms and found that the effects of MTX might be linked to endoplasmic reticulum (ER) stress, which appeared to trigger cell apoptosis in fibroblasts. This suggests that MTX could potentially help in regulating scar formation which is often at the root of chronic back pain.
Overall, our findings indicate that while MTX does not target folate directly, its therapeutic properties may offer a new avenue for managing post-surgical back pain through its effects on EF and associated cellular pathways.
9.5
Alleviates PMS pain
Most Useful Review
After a month of use, back pain during menstruation disappeared and I take these courses periodically.
Cold details
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.4
8
We explored the intriguing case of a patient battling severe anemia after a COVID-19 infection. This patient exhibited both cold agglutinin and cryoglobulin, revealing some interesting findings when we examined their direct antiglobulin test results.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
We noted that the test showed C3d positivity while being immunoglobulin G negative, indicating that the patient did not have evident hemolytic anemia or thrombosis. Interestingly, there was no clinically significant IgM monoclonal gammopathy reported, which suggests that the situation might not be as dire as it seems at first glance.
Treatment involved folic acid supplementation, which led to a noticeable improvement in the patient's anemia. Alongside this, we observed a decrease in the cold agglutination titer, and the direct antiglobulin test turned negative, hinting that folate may play a role in managing cold agglutinin-related issues, though it’s essential to view this within the broader context of other influences.
Despite the persistent cryoglobulinemia, the patient did not experience thrombosis or any significant complications. This case prompts us to carefully consider the use of immunosuppressive therapies for cold-related hematologic disorders following COVID-19, particularly as many factors may be at play in affecting patient outcomes.
8.8
Feeling better overall
Most Useful Review
I started feeling cold and depressed, so I researched and learned that a folic acid deficiency could lead to depression. I began taking it as a supplement. After about a month, I haven't caught a cold, which suggests it’s working well. My mood has also improved.
Blurred Vision details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.3
9.5
Overall health enhancement
Most Useful Review
My condition is improving every day, with noticeably better skin, hair, and nails. Additionally, my hearing and vision have also enhanced significantly. I am incredibly pleased with these products. Thank you!
Bone Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 5 Reviews
8.3
8
We aimed to understand how folic acid affects bone cancer pain, a challenging condition that isn't easily managed with typical treatments. In our study, we induced bone cancer pain in rats by injecting Walker 256 tumor cells into their tibia. To assess pain response, we measured how quickly they withdrew their paws in response to pressure and heat.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
Throughout the study, we found that rats suffering from bone cancer pain showed a significant reduction in their pain thresholds. However, with continuous folic acid treatment, these thresholds improved, indicating a notable analgesic effect. We examined the levels of P2X2 and P2X3 receptors—known to play a role in pain signaling—and noticed they were elevated in the pain-afflicted rats. Remarkably, folic acid treatment resulted in a notable decrease in these receptors in both the spinal cord and relevant nerve ganglia.
This suggests that folic acid not only relieves pain but also acts by downregulating specific receptors associated with pain. We believe that our findings position folic acid as a promising option for alleviating bone cancer pain in clinical settings.
9.5
Reduced bone pain
Most Useful Review
Most advisors recommend this product for pregnancy. As a young unmarried woman, I found it beneficial for long hair and nails, strengthening them and alleviating symptoms of bone pain. It also resolved my constipation and regularised my period without delay or cramps. I took one pill daily after breakfast for two months and saw impressive results. The quantity is plentiful, the price is low, and the pills are small and easy to swallow. Stay hydrated for the best results.
Cancer details
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.5
USERS' SCORE
Good
Based on 10 Reviews
8.3
9
We developed a folic acid-targeted liposome system to improve the delivery of sorafenib, a drug used in treating liver cancer. Through various techniques, we created liposomes loaded with sorafenib and evaluated their effects on liver cancer cells. Our results showed that this targeted system effectively inhibited cancer cell growth and induced apoptosis in vitro. Additionally, in a liver xenograft model, it successfully slowed tumor progression. Overall, our findings suggest that this targeted delivery method could enhance liver cancer therapy while minimizing side effects.
9.5
Reduces stomach cancer
Most Useful Review
During times of stress, like war, one folic acid tablet significantly reduces the risk of stomach cancer from alcohol consumption.
High Cholesterol details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 4 Reviews
8.3
7
We set out to understand how folic acid (FA) levels relate to high cholesterol and the risk of atherosclerosis, a leading cause of heart disease. Utilizing a method called Mendelian randomization, which leverages genetic data to uncover causal relationships, we explored the connection between genetically determined FA levels and atherosclerosis risk.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
Our findings revealed that higher FA levels are linked to a lower risk of atherosclerosis. Specifically, we observed that individuals with greater FA levels had favorable cholesterol profiles—showing higher levels of good cholesterol (HDL-C) and lower levels of bad cholesterol (LDL-C) and triglycerides (TG). This suggests that FA might exert a protective effect on heart health by improving lipid levels.
Interestingly, we found that LDL-C, HDL-C, and TG together mediate a notable portion of this relationship, accounting for just over 13% of the total impact of FA on atherosclerosis. In simpler terms, improving cholesterol could be a significant part of how folic acid helps reduce heart disease risk.
Overall, this study emphasizes the importance of maintaining healthy folate levels, as it can be a vital step in reducing cholesterol and, consequently, lowering cardiovascular risks.
9.5
Supports heart health
Most Useful Review
Folic acid is an essential B vitamin (B9) that contributes to heart health. Regular intake reduces the risk of stroke and cardiovascular disorders, normalises blood pressure, and lowers high cholesterol. It’s also vital during pregnancy for cell creation and maintaining a healthy state.
Adenoiditis details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.2
8.8
Effective sore throat relief
Most Useful Review
I liked this medication. Personally, I find it effective for a long time. I don't use it frequently, but as soon as I sense the onset of a sore throat, after taking a few tablets a day, everything improves. The taste is pleasant. It’s wise to keep it in reserve for times of weakened immunity. I recommend it!
Stroke details
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.8
USERS' SCORE
Good
Based on 3 Reviews
8.2
9
We explored the cost-effectiveness of different folic acid supplementation strategies aimed at preventing strokes in hypertensive individuals in China. By examining four policy options, we aimed to find the best approach to support stroke prevention while considering potential complications from undetected vitamin B12 deficiencies.
The policies varied from simply not addressing folate levels to providing targeted folate supplements after screening for B12 deficiencies. Our analysis, based on a five-year intervention modeled from the China Stroke Primary Prevention Trial, found that the most effective strategy combined folate supplementation with screening for both folate and B12 deficiencies.
This combination not only helped prevent strokes but also ensured that those with B12 deficiency received appropriate treatment. The implications of this research suggest that adopting integrated screening approaches could greatly enhance public nutrition strategies, ultimately saving costs and improving health outcomes for at-risk populations.
The policies varied from simply not addressing folate levels to providing targeted folate supplements after screening for B12 deficiencies. Our analysis, based on a five-year intervention modeled from the China Stroke Primary Prevention Trial, found that the most effective strategy combined folate supplementation with screening for both folate and B12 deficiencies.
This combination not only helped prevent strokes but also ensured that those with B12 deficiency received appropriate treatment. The implications of this research suggest that adopting integrated screening approaches could greatly enhance public nutrition strategies, ultimately saving costs and improving health outcomes for at-risk populations.
9.5
Supports heart health
Most Useful Review
Excellent! Folic acid is an essential B vitamin (B9) that aids heart health. Regular consumption of the recommended dose with food reduces the risk of stroke and cardiovascular issues, normalises blood pressure, and lowers cholesterol levels. It also plays a vital role during pregnancy, promoting the creation and maintenance of healthy body cells, which is crucial during fetal development and early childhood, helping to prevent premature births and postpartum depression.
Abscess details
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.1
9.5
Cyst resolved
Most Useful Review
The doctor informed me that the cyst might be linked to a folate deficiency, so I took it alongside Omega 3 to manage the issue. Thankfully, the cyst has disappeared. The ingredients are of good quality, and the quantity provided is ample enough to last for months.
Heart Attack details
SCIENTIFIC SCORE
Questionable
Based on 23 Researches
5.8
USERS' SCORE
Moderately Good
Based on 13 Reviews
7.9
9
We explored how folic acid could influence recovery after a heart attack. Through a study on mice, we induced heart attacks and then treated them with folic acid for four weeks. The results were promising, showing that the treatment improved heart function and increased essential enzyme levels that help process homocysteine, a harmful byproduct in the body.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
However, the link between folic acid and heart attack recovery remains complex, and further studies are necessary to substantiate these findings in humans.
8.8
Cell growth support
Most Useful Review
Folic acid is a vital B vitamin essential for DNA construction in all cells. A recommended dosage is one 400 mg tablet daily during the fertility period. It promotes new cell formation, contributing to smooth skin, thick hair, and strong nails. It's important to combine it with B12 and B6 for optimal absorption and metabolic rate, also helping to reduce the risk of heart attack and strengthen blood vessel walls.
Chest Pain details
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.8
8
We explored the impact of folic acid on patients experiencing unstable angina and high levels of homocysteine, a condition associated with heart issues. Our investigation involved 52 individuals with unstable angina and 30 control subjects, measuring levels of plasma homocysteine, folic acid, and vitamin B12.
Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.
Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.
Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
9.5
Pain relief noted
Most Useful Review
Excellent! It significantly helps with my back pain, especially when taken with the B12 from 21st Century. The quality and price are great. I understand that folic acid is important for reducing deficiencies in the brain and spine, particularly during the first month of pregnancy when risks are highest. Please give a like, blessings to you!🙏🌻
Pelvic Pain details
SCIENTIFIC SCORE
Likely Very Effective
Based on 2 Researches
9
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.4
9
We explored an innovative treatment for chronic bacterial prostatitis (CBP) by creating antibiotic-loaded nanoparticles modified with folic acid. These nanoparticles can effectively target and penetrate the prostate tissues where inflammation and pain occur.
In animal models, the folic acid-modified nanomedicine significantly alleviated pelvic pain and reduced inflammatory markers. This targeted approach enhances antibiotic delivery and improves treatment outcomes for CBP. Although the study showcases promising results, more research is needed to translate these findings to human patients.
In animal models, the folic acid-modified nanomedicine significantly alleviated pelvic pain and reduced inflammatory markers. This targeted approach enhances antibiotic delivery and improves treatment outcomes for CBP. Although the study showcases promising results, more research is needed to translate these findings to human patients.
9.5
Pelvic pain relief
Most Useful Review
After one month of taking the drug, my pelvic pain during menstruation disappeared. I occasionally take courses to maintain this benefit.
Autoimmune Disorder details
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.3
USERS' SCORE
Moderately Good
Based on 2 Reviews
7.3
9
Folic acid improves rheumatoid arthritis treatment
We explored the use of ginger-derived extracellular vesicles modified with folic acid to treat rheumatoid arthritis, a painful autoimmune condition. By enhancing these vesicles to target the inflammatory cells in affected joints, we found that they help shift the immune response towards healing. Our in vitro and in vivo studies showed promising results: these folic acid-infused vesicles not only concentrated in the inflamed areas but also significantly reduced RA symptoms. This suggests that folic acid-modified vesicles could be a safe and effective alternative treatment option for RA.
5.5
Essential for health
Most Useful Review
As a professional in the field, I believe folic acid is crucial for anyone at least once in their life. It plays a significant role in brain health and can combat an autoimmune disorder by protecting cells and aiding red blood cell production. It helps reduce anxiety and stress, and is particularly important before pregnancy. Consult a doctor for personalised advice.
Sleep Apnea details
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.2
USERS' SCORE
Moderately Good
Based on 4 Reviews
7
7
Folic acid linked to OSA severity
We examined the connection between dietary components and the severity of obstructive sleep apnea (OSA) in a group of 303 adults from Cyprus.
The study indicated that higher energy intake increases OSA severity. However, we noticed that participants with higher folic acid intake tended to have less severe cases of OSA.
Thus, while diet impacts OSA severity, folic acid may offer a protective benefit that could be significant in managing this condition.
The study indicated that higher energy intake increases OSA severity. However, we noticed that participants with higher folic acid intake tended to have less severe cases of OSA.
Thus, while diet impacts OSA severity, folic acid may offer a protective benefit that could be significant in managing this condition.
9.5
Health benefits attained
Most Useful Review
Mumtaz is a wonderful product. The small grains lack smell or taste, making them easy to consume. Their benefits for the brain, heart, mood, and sleep are essential and effective for anyone caring about their health.
