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Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
667 mcg DFE (400 mcg Folic Acid)
167%
Calcium (as Calcium Carbonate)
100 mg
8%
The product is found useful for the following medical conditions
Common Cold
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 5 Reviews
9.4
9.5
Improved immunity
Most Useful Review
Excellent! I have been taking these vitamins for a few weeks now and feel like I’m embarking on something new. I no longer feel tired or in pain, and my mood has significantly improved! I’ve even noticed that I’m less prone to catching a common cold than before. These vitamins are fantastic!
Anemia
SCIENTIFIC SCORE
Most Likely Effective
Based on 15 Researches
7.1
USERS' SCORE
Very Good
Based on 28 Reviews
8.8
9
Folate supplementation improves anemia
Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study.
Most Relevant Research
We conducted a study to understand how a school-based program offering weekly iron and folic acid supplements affects anemia, particularly focusing on the serum folate levels in adolescent girls aged 10 to 19 in the Sidama Region of Southern Ethiopia.
Our research compared 165 girls from schools participating in the supplementation program to 165 girls from schools without this initiative. We measured the serum folate levels, alongside hemoglobin concentrations, to get a clearer picture of the program's effectiveness.
The results were promising. We observed that the girls receiving the supplements had a significantly higher mean serum folate concentration of 9.76 ng/mL compared to 7.38 ng/mL in those who did not receive the supplementation. Additionally, the hemoglobin levels were higher in the supplemented group, suggesting a positive effect on overall health.
This highlights the importance of the WIFAS program not just for iron levels but also for folate status, indicating a crucial step in tackling anemia in vulnerable populations. We are optimistic that this evidence can help advocate for the program's expansion in areas facing deficiencies in both iron and folate.
Our research compared 165 girls from schools participating in the supplementation program to 165 girls from schools without this initiative. We measured the serum folate levels, alongside hemoglobin concentrations, to get a clearer picture of the program's effectiveness.
The results were promising. We observed that the girls receiving the supplements had a significantly higher mean serum folate concentration of 9.76 ng/mL compared to 7.38 ng/mL in those who did not receive the supplementation. Additionally, the hemoglobin levels were higher in the supplemented group, suggesting a positive effect on overall health.
This highlights the importance of the WIFAS program not just for iron levels but also for folate status, indicating a crucial step in tackling anemia in vulnerable populations. We are optimistic that this evidence can help advocate for the program's expansion in areas facing deficiencies in both iron and folate.
9.5
Organised menstruation
Most Useful Review
I am a young woman and found this product beneficial for my long hair and nails while addressing anemia. I experienced palpitations and heart discomfort, but after taking these pills, I no longer do. Constipation issues also improved, and my period became regular, arriving on time with no pain. I took one pill daily for two months, noticing great results. The bottle was substantial, reasonably priced, and the small pills were easy to swallow. Drink plenty of water while taking folic acid for the best results.
Blood Clot
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 2 Reviews
8.8
8.8
Improved blood flow
Most Useful Review
Folic acid is essential for supporting blood vessels and the heart. My gynecologist prescribed it after poor blood clot test results. These vitamins suited me; the size and dosage are convenient, and the quality is excellent. The packaging is practical, and the taste is neutral. I feel that my nervous system has improved, my metabolism has sped up, and I have plenty of energy.
Liver Disease
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
6.8
USERS' SCORE
Very Good
Based on 1 Reviews
8.8
9
Folate treatment aids liver fat reduction
DNA hypermethylation-induced suppression of ALKBH5 is required for folic acid to alleviate hepatic lipid deposition by enhancing autophagy in an ATG12-dependent manner.
Most Relevant Research
We investigated the effects of folic acid treatment on nonalcoholic fatty liver disease (NAFLD), a condition where excess fat builds up in the liver, often linked to obesity and insulin resistance. Our research revealed that giving folic acid to mice on a high-fat diet helped improve their glucose tolerance and insulin sensitivity, alongside reducing unhealthy fat levels in their liver cells.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
By diving into the mechanisms, we discovered that folic acid works by changing the DNA methylation patterns that regulate the expression of a protein called ALKBH5. This reduction in ALKBH5 levels led to an increase in a specific type of RNA modification and subsequently boosted the production of a protein called ATG12, which is vital for autophagy – the process that cleans up and recycles cellular components.
When we inhibited ATG12 through overexpression of ALKBH5, autophagy was impeded, showcasing how crucial ATG12 is for allowing folic acid to effectively reduce fat accumulation in the liver. Overall, these findings indicate that folic acid could be a promising nutritional ally in fighting NAFLD, revealing a clear mechanism by which it protects liver health.
8.8
Improved haemoglobin levels
Most Useful Review
I take folic acid alongside iron supplements to restore my haemoglobin levels and increase ferritin, as Vitamin B9 enhances iron absorption. While many believe folic acid is solely for pregnant women, its deficiency can also occur without pregnancy, particularly in individuals with chronic gastrointestinal disorders. I consume one tablet of 21st Century folic acid each morning with my iron supplements, and I have experienced no side effects. Over several months, this combination has significantly raised my haemoglobin to the desired level.
Cardiovascular Disease
SCIENTIFIC SCORE
Most Likely Effective
Based on 4 Researches
7.5
USERS' SCORE
Very Good
Based on 21 Reviews
8.7
8
Folate's potential in heart health
Atherogenic Effect of Homocysteine, a Biomarker of Inflammation and Its Treatment.
Most Relevant Research
We have explored how folate, a vital B-vitamin, may play a crucial role in lowering homocysteine levels, which is linked to heightened risks of cardiovascular diseases. The study highlights how high levels of homocysteine can contribute to atherosclerosis, a silent but dangerous condition leading to heart disease and stroke.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
Our findings suggest that by increasing folate intake, either through supplements or dietary sources, we can effectively reduce homocysteine levels. This, in turn, might decrease the risk of developing related cardiovascular issues. Observations indicate that folate, along with other B-vitamins, can positively influence heart health and protect against the attack of atherosclerosis.
However, it’s worth noting that while folate is a significant player in this context, the exact impact can vary depending on individual health conditions and existing dietary habits. Therefore, a well-rounded approach to nutrition, including other vitamins and lifestyle changes such as quitting smoking and reducing alcohol intake, complements the benefits of folate for cardiovascular health.
9.5
Improved hemoglobin levels
Most Useful Review
Folic acid aids in treating anaemia. I take it alongside iron supplements to improve my haemoglobin levels. Folic acid enhances iron absorption. It’s often mistakenly viewed as solely for pregnant women, but deficiency can occur in anyone, especially those with gastrointestinal issues. I've raised my haemoglobin to target levels without side effects.
Heart Disease
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 36 Reviews
8.6
8.8
Affordability and quality
Most Useful Review
Folic acid is beneficial not only for women planning pregnancy but also for men, helping with heart health and immunity. It has an excellent price/quality ratio and lasts over a month, making it a wise investment in health, especially concerning heart disease.
Back Pain
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 5 Reviews
8.3
9.5
Alleviates PMS pain
Most Useful Review
After a month of use, back pain during menstruation disappeared and I take these courses periodically.
High Cholesterol
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Very Good
Based on 4 Reviews
7.7
9.5
Supports heart health
Most Useful Review
Folic acid is an essential B vitamin (B9) that contributes to heart health. Regular intake reduces the risk of stroke and cardiovascular disorders, normalises blood pressure, and lowers high cholesterol. It’s also vital during pregnancy for cell creation and maintaining a healthy state.
Heart Attack
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
6.3
USERS' SCORE
Very Good
Based on 13 Reviews
7.5
8
Folic acid shows cardioprotective effects
Effect of folic acid on isoprenaline-induced myocardial injury in rats.
Most Relevant Research
We aimed to understand how folic acid (FA) might help protect the heart during instances of myocardial injury, specifically when induced by isoprenaline, a substance known to trigger such damage in experimental settings with rats. Our study involved administering FA to a group of adult male Wistar albino rats over a week, alongside inducing myocardial injury on the final days of the treatment.
The results of our study were promising; we found that FA pretreatment significantly softened the adverse effects typically caused by isoprenaline. Important markers that indicate heart damage, like homocysteine and high-sensitivity troponin I levels, were reduced after FA treatment. Additionally, levels of harmful reactive oxygen species (ROS) were lowered, and the benefits extended to enhanced antioxidant activities in the rat hearts.
Overall, our findings suggest that folic acid may serve as a gentle but effective cardioprotective agent in this model of myocardial injury. It’s encouraging to see that simple nutritional supplementation could have such a positive impact on heart health, particularly in scenarios mimicking heart attacks. This opens up exciting possibilities for future research in cardioprotection and dietary interventions for heart health.
The results of our study were promising; we found that FA pretreatment significantly softened the adverse effects typically caused by isoprenaline. Important markers that indicate heart damage, like homocysteine and high-sensitivity troponin I levels, were reduced after FA treatment. Additionally, levels of harmful reactive oxygen species (ROS) were lowered, and the benefits extended to enhanced antioxidant activities in the rat hearts.
Overall, our findings suggest that folic acid may serve as a gentle but effective cardioprotective agent in this model of myocardial injury. It’s encouraging to see that simple nutritional supplementation could have such a positive impact on heart health, particularly in scenarios mimicking heart attacks. This opens up exciting possibilities for future research in cardioprotection and dietary interventions for heart health.
8.8
Cell growth support
Most Useful Review
Folic acid is a vital B vitamin essential for DNA construction in all cells. A recommended dosage is one 400 mg tablet daily during the fertility period. It promotes new cell formation, contributing to smooth skin, thick hair, and strong nails. It's important to combine it with B12 and B6 for optimal absorption and metabolic rate, also helping to reduce the risk of heart attack and strengthen blood vessel walls.
Chest Pain
SCIENTIFIC SCORE
Most Likely Effective
Based on 2 Researches
7.5
USERS' SCORE
Medium or Average
Based on 4 Reviews
6.2
8
Folic acid improves angina symptoms
Most Relevant Research
We explored the impact of folic acid on patients experiencing unstable angina and high levels of homocysteine, a condition associated with heart issues. Our investigation involved 52 individuals with unstable angina and 30 control subjects, measuring levels of plasma homocysteine, folic acid, and vitamin B12.
Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.
Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
Patients identified with high homocysteine levels received 5 mg of folic acid for two months. We checked their homocysteine, folic acid, and vitamin B12 levels again after four and eight weeks. Additionally, we assessed how folic acid treatment affected the functioning of their arteries by measuring blood flow in the arms.
Our findings revealed that folic acid can successfully lower homocysteine levels and improve the functioning of arteries in those suffering from unstable angina. This suggests that folic acid may have a beneficial role in managing symptoms related to chest pain in these patients.
9.5
Pain relief noted
Most Useful Review
Excellent! It significantly helps with my back pain, especially when taken with the B12 from 21st Century. The quality and price are great. I understand that folic acid is important for reducing deficiencies in the brain and spine, particularly during the first month of pregnancy when risks are highest. Please give a like, blessings to you!🙏🌻
