Doctor&#039;s Best High Absorption CoQ10 with Bioperine

Hu YF, Wu CH, Lai TC, Chang YC, Hwang MJ, et al. ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis. Biochim Biophys Acta Mol Basis Dis. 2021;1867:166088. doi:10.1016/j.bbadis.2021.166088

Based on 3 Researches

ALDH2 mutation and CoQ10 impacts

Our investigation centered around the effects of a genetic mutation in the ALDH2 enzyme, known as ALDH2*2, on the risk of developing atrial fibrillation (AF). We discovered that this mutation led to an increased incidence of AF in mice, accompanied by a decrease in the threshold for AF events compared to their non-mutant counterparts.

A key finding in our study was the alteration in signaling pathways related to retinoic acid, which impacted the expression of crucial sodium channels involved in heart rhythm. The reduced levels of these channels, specifically the SCN5A, raised concerns about their role in AF susceptibility.

We also conducted a multi-omics analysis that revealed disruptions in fatty acid metabolism and energy production within the mitochondria, leading to heightened oxidative stress. To counter these issues, we administered Coenzyme Q10, a well-known mitochondrial co-factor, to the mutant mice. Remarkably, this treatment offered protection against AF episodes.

By bridging our findings, we could see how Coenzyme Q10 may pave the way for personalized treatment options for individuals with the ALDH2*2 genotype at risk for AF, making it a potential game-changer in managing heart health.

9.5

Significant improvement

Most Useful Review

My mother suffered from atrial fibrillation for years, enduring frequent hospital visits. After a heart attack, she began taking coenzyme Q10, initially at 60-90 mg daily. Within five months, her arrhythmia attacks ceased, and her overall health improved. Now she takes 100 mg daily without interruption, having bought the supplement abroad at a much lower price. Both my husband and I have also started taking it, and we've noticed increased energy and better health.

Cardiovascular Disease details

CoQ-10 reduces mortality, improves capacity

Based on 10 Researches

Qazi SU, Bin Naeem MA, Umar M, Zahid MJ, Kan Changez MI, et al. Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis. Future Cardiol. 2024;20:221. doi:10.1080/14796678.2024.2352308

We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.

In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.

9.5

Improved health

Most Useful Review

My journey with Coenzyme Q10 began two years ago after my mother's heart attack. She suffered from cardiovascular disease and had many related complications. After starting CoQ10, along with other supplements, her arrhythmia attacks ceased within five months. We've now been taking it for two years. I noticed a significant boost in my energy and overall performance since starting CoQ10 myself. It appears to enhance heart health and has notably improved our well-being, making it a vital addition to our health regimen.

Chronic Fatigue Syndrome details

Ubiquinol-10 benefits chronic fatigue syndrome

Based on 15 Researches

Fukuda S, Nojima J, Kajimoto O, Yamaguti K, Nakatomi Y, et al. Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome. Biofactors. 2016;42:431. doi:10.1002/biof.1293

We embarked on a study to investigate the impact of ubiquinol-10—an active form of coenzyme Q10—on patients suffering from chronic fatigue syndrome (CFS). Our research comprised two parts: an open-label study involving 20 patients and a randomized, double-blind, placebo-controlled trial with 43 participants.

In the open-label segment, patients took 150 mg of ubiquinol-10 daily for eight weeks, and both the participants and physicians knew who was receiving the supplement. The results were promising, suggesting improvements in various symptoms of CFS.

Following this, in the randomized trial, participants were assigned to either ubiquinol-10 or a placebo for 12 weeks, with neither the patients nor the doctors aware of who received which treatment. Outcomes showed that those taking ubiquinol-10 experienced significant benefits, reinforcing the notion that this supplement can positively influence CFS symptoms.

Overall, this study suggests that adding ubiquinol-10 to a treatment plan could be a helpful strategy for improving the lives of those dealing with chronic fatigue syndrome.

Boosted energy levels

Most Useful Review

I experienced a surge of energy after a couple of months taking CoQ10. I found it easier to get up in the mornings and felt great during training. Most importantly, I no longer suffered from fatigue post-training, which I struggled with after my second child. I take 1 capsule daily. If this review helps, I’m pleased! Wishing you all health and energy!

Hypertension details

Citicoline and CoQ10 protection study

Matamoros JA, Rubio-Casado S, Fernández-Albarral JA, Martínez-López MA, Salobrar-García E, et al. Neuroprotective Effect of the Combination of Citicoline and CoQ10 in a Mouse Model of Ocular Hypertension. Antioxidants (Basel). 2024;14. doi:10.3390/antiox14010004

We investigated how a combination of citicoline and coenzyme Q10 (CoQ10) might impact retinal cell health in a mouse model of ocular hypertension (OHT). Using four groups of mice, including those receiving the combination treatment and a control group, we aimed to understand if these substances could protect against the loss of retinal ganglion cells, which is a major concern in glaucoma.

The treatment was started 15 days prior to inducing ocular hypertension with a laser and continued until we examined the mice about a week later. Our findings were promising: the combination of citicoline and CoQ10 led to a temporary reduction in eye pressure shortly after treatment. Furthermore, it significantly prevented the death of specific retinal cells that are vital for vision.

While we were encouraged by these results, especially regarding cell protection, it's important to note that there were no significant impacts on neurons in the visual pathway areas we studied, like the dLGN. Overall, our research suggests that this combination might offer neuroprotective benefits in specific aspects of ocular hypertension, paving the way for further exploration into treatments that go beyond only lowering eye pressure.

9.5

Significant improvement

Most Useful Review

My mother had a heart attack two years ago and suffered from various heart conditions and constant arrhythmia. After starting coenzyme Q10, her attacks stopped within five months, and her overall health improved significantly. She took it alongside Omega 3 and other supplements. We found that 100 mg daily works well, and buying from iHerb has been far more affordable than in Russia.

Liver Disease details

Vrentzos E, Ikonomidis I, Pavlidis G, Katogiannis K, Korakas E, et al. Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial. Cardiovasc Diabetol. 2024;23:245. doi:10.1186/s12933-024-02326-8

Based on 11 Researches

Coenzyme Q10 improves liver health

We conducted a study to explore the effects of high-dose coenzyme Q10 supplementation on patients suffering from liver disease related to metabolic dysfunction, known as Metabolic-dysfunction Associated Steatotic Liver Disease (MASLD). In a well-structured double-blind, placebo-controlled trial with sixty participants, half received 240 mg of coenzyme Q10 daily, while the other half received a placebo for six months.

Our findings were promising. Patients taking coenzyme Q10 showed significant improvements in various aspects of their health related to liver functions and cardiovascular health. Specifically, we observed a reduction in liver fat content, as assessed by the controlled attenuation parameter, along with better blood vessel function and heart performance. For instance, the flow-mediated dilation of the brachial artery and the coronary flow reserve significantly improved in those receiving the supplement.

Interestingly, while the placebo group did not show any improvements during the six-month period, the coenzyme Q10 group demonstrated a clear correlation between the reduction in liver fat and enhancements in micro- and macrovascular functions. These results suggest that coenzyme Q10 could potentially be a beneficial treatment option for those battling MASLD.

9.5

Improved liver health

Most Useful Review

I want to share my experience with coenzyme Q10. I noticed numbness in my legs while sitting for long hours. After taking coenzyme Q10 daily for over two years, along with fish oil, my liver responded well, and the nocturnal pain diminished. I recently made a long car trip without leg issues, and I no longer feel cold in winter. Coenzyme Q10 has had a remarkable impact on my health, so I recommend trying it!

Allergies details

Co-Q10 aids allergic reaction control

Du Q, Meng W, Athari SS, Wang R. The effect of Co-Q10 on allergic rhinitis and allergic asthma. Allergy Asthma Clin Immunol. 2021;17:32. doi:10.1186/s13223-021-00534-5

We investigated how coenzyme Q10 (Co-Q10) affects allergies, particularly allergic rhinitis and asthma. In our study, we used animal models to mimic these conditions and treated them with Co-Q10, either alone or alongside other compounds like Omega-3 and magnesium sulfate.

We collected and analyzed samples from the lungs, measuring various inflammatory markers such as cytokines and IgE levels, which play critical roles in allergic reactions. The results indicated that Co-Q10 helps promote the activity of a protective protein called Nrf2, which is crucial in defending against allergic responses and inflammation.

By increasing Nrf2 levels, Co-Q10 showed potential in reducing the symptoms associated with allergic conditions, helping to control allergic mediators and inflammatory factors. Overall, we found that Co-Q10 treatment could enhance the body’s resilience to allergens, potentially offering a powerful tool against allergic rhinitis and asthma.

9.5

Increased energy

Most Useful Review

I genuinely appreciate this vitamin. I often feel tired, but since taking this supplement, my energy levels have improved significantly. It’s also suitable for vegans, which is great for those with allergies.

Common Cold details

I’m a mother of three and was constantly catching infections from my children. No amount of rest seemed to help. After researching adrenal fatigue, I began taking Eleuthero, Astragalus, CoEnzyme Q10, and D-Ribose. The difference is astounding; I haven’t had a single bad chest infection this winter. I often felt a cold coming on, but it vanished by the next day. My immune system is clearly boosted, and I will continue with this combination.

Depression details

Q10 alleviates post-stroke depression

Based on 13 Researches

Fatemi I, Saeed Askari P, Hakimizadeh E, Kaeidi A, Esmaeil Moghaddam S, et al. Chronic treatment with coenzyme Q10 mitigates the behavioral dysfunction of global cerebral ischemia/reperfusion injury in rats. Iran J Basic Med Sci. 2022;25:39. doi:10.22038/IJBMS.2022.57630.12865

We explored the effects of Coenzyme Q10 (Q10) on depression and cognitive deficits following global cerebral ischemia/reperfusion (I/R) injury in rats. In this study, we induced brain injury by blocking blood flow to both carotid arteries for 20 minutes. The rats then received Q10 at a dose of 200 mg/kg for six weeks.

The results illustrated that the I/R injury led to increased anxiety and depressive behaviors in the animals, alongside a noticeable decline in cognitive performance. Moreover, we found that the levels of brain-derived neurotrophic factor (BDNF) and the activity of superoxide dismutase (SOD) were reduced after the stroke.

Upon treating with Q10, we observed significant improvements. The treatment not only decreased brain swelling but also lessened anxiety and depressive-like symptoms. Cognitive impairments improved as well, with increased BDNF levels and SOD activity in the brain tissues of the animals receiving Q10.

Ultimately, this study points to the potential benefits of Q10 supplementation in mitigating symptoms of depression and cognitive issues after a stroke.

Supports depression relief

Most Useful Review

Coenzyme Q10 is vital for energy production and has notably improved my well-being. After noticing its benefits, including reduced fatigue and enhanced mood, I’ve encouraged others to try it. My mother, who leads an unhealthy lifestyle, experienced a significant uplift in her energy levels and mood after taking it. It's an essential support for heart health and an effective remedy for depression.

Heart Disease details

CoQ-10 improves heart failure outcomes

We explored the effectiveness of coenzyme Q10, commonly known as CoQ-10, in treating heart failure (HF) by reviewing multiple studies. Our systematic analysis included research from respected databases like MEDLINE and the Cochrane Library, where we focused on three main outcomes: heart failure-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).

From the 16 studies we examined, we observed that CoQ-10 treatment significantly decreased HF-related mortality by an impressive 40%. Additionally, we noted improvements in exercise capacity among patients, indicating that CoQ-10 could help individuals with heart failure engage in more physical activity and improve their quality of life.

However, when it came to LVEF—the measurement of how well the heart pumps blood—CoQ-10 did not show significant changes. Despite this, we believe that its potential impact on LVEF should be investigated further, as the data does suggest there may be benefits that warrant additional research.

In summary, while CoQ-10 proved to be beneficial in enhancing exercise capacity and reducing mortality associated with heart failure, the exact effects on LVEF remain unclear and would benefit from more focused studies in the future.

9.5

Supports heart health

Most Useful Review

This product works excellently! Coenzyme Q10 is vital for heart health and energy production, also acting as a powerful immunomodulator. It can even help slow down aging. I suggest combining it with Omega 3 for better results. Just be cautious as it may lower blood pressure. I've ordered numerous supplements from iHerb, and I believe they can aid in maintaining our health.

Adrenal Gland Disorder details

Huge difference! As a mother of three working full-time, I was constantly run down and susceptible to every infection my kids brought home. Despite getting plenty of rest, I remained tired. My instincts told me my adrenals were involved, so I researched adrenal fatigue and began taking Eleuthero, Astragalus, CoEnzyme Q10, D-Ribose, and a general multivitamin. The improvement has been astounding. We are two months into winter in Australia, and usually, I would have had at least three severe chest infections by now, but I haven't had a single one. I occasionally felt a cold coming on, but it vanished by the following day. My immune system is undeniably strong. I will continue with this combination and appreciate iHerb's low-cost international shipping!

Bacterial Infection details

Healing gum infections

Very effective in alleviating periodontitis and persistent gum infections. I struggled with periodontitis for a decade, despite careful hygiene and regular dentist visits. After starting Coenzyme Q10 at 100 mg twice daily two months ago, my gums began healing by day two. My previously shaky tooth is now firm, and I've had no infections since starting this supplement. Moreover, my palpitations have significantly decreased. I'm incredibly grateful to have discovered this!

Blood Clot details

Ya F, Xu XR, Shi Y, Gallant RC, Song F, et al. Coenzyme Q10 Upregulates Platelet cAMP/PKA Pathway and Attenuates Integrin αIIbβ3 Signaling and Thrombus Growth. Mol Nutr Food Res. 2019;63:e1900662. doi:10.1002/mnfr.201900662

Based on 5 Researches

CoQ10 reduces harmful blood clots

We explored how coenzyme Q10 (CoQ10), a natural compound found in various foods, impacts blood clotting functions. Through a well-structured study, we utilized a randomized, double-blind, placebo-controlled trial with dyslipidemic patients, alongside in vitro tests on human platelets.

Our findings demonstrated that CoQ10 effectively reduces platelet aggregation, granule secretion, platelet spreading, and clot retraction. This means that CoQ10 can help prevent excessive blood clot formation, which is crucial for cardiovascular health.

We observed that CoQ10 works mainly by enhancing a signaling pathway involving cyclic AMP (cAMP) which ultimately diminishes the signaling of integrin αIIbβ3, a key player in platelet function. In addition, the treatment showed promising results in reducing thrombus growth in an animal model, suggesting significant in vivo benefits as well.

This study highlights the potential of CoQ10 supplementation as a protective measure for individuals at risk of cardiovascular diseases by regulating platelet-related processes involved in clotting.

9.5

Less migraine pain

Most Useful Review

I've suffered from severe migraines since I was 13. Despite trying various medications, I found CoQ10 to be very effective. It has significantly reduced my migraine frequency and pain. I'm on my second dose now and its natural benefits have impressed me.

Bone Pain details

Struggling with poor sleep for years, I was initially sceptical of this product. However, after taking it, I found I could stay awake and active throughout the day, improving not only my mental and physical strength but also easing my bone pain. It feels like I’ve regained my youthful vitality, and I plan to continue using it.

Celiac details

Prevented gluten poisoning

I am very pleased with the purchase; it is gluten free, which is essential for me to avoid poisoning my body.

Chemotherapy details

Increased energy levels

This is an excellent product for boosting my energy levels, thanks to its high BioPerine content for better absorption. As a cancer patient, I take this supplement among others to maintain my energy. While I believe it’s the combination of all these products that aid me, I am certain this one plays a vital role in my wellbeing. After undergoing 43 chemotherapies, including a stem cell transplantation in April 2011, I am truly grateful to feel this way.

Chest Pain details

Coenzyme Q10 improves angina symptoms

Kuimov AD, Murzina TA. [Coenzyme q10 in complex therapy of patients with ischemic heart disease]. Kardiologiia. 2013;53:40.

We assessed the effects of coenzyme Q10 on patients suffering from ischemic heart disease, specifically those experiencing stable class II-III angina. In our study, we added coenzyme Q10 at a dosage of 60 mg per day for eight weeks to the standard treatment regimen these patients were already following.

The results showed that this addition significantly improved the clinical status of the patients. Importantly, we did not observe any clinically significant side effects associated with the use of coenzyme Q10. This suggests that it could be a beneficial adjunct therapy for individuals dealing with chest pain related to cardiac issues, enhancing their treatment experience without additional risk.

9.5

Heart protection

Most Useful Review

I recently tried a coenzyme Q10 supplement and I’m absolutely pleased with the results. It greatly protects my heart during exercise, and as a powerful antioxidant, it aids my overall health. Highly recommended for those over 40!

Ear Infection details

Myringosclerosis prevention ineffective

Very Likely Ineffective

Aydoğan F, Aydin E, Taştan E, Akgedik Ş, Tekeli A, et al. Is there any effect of coenzyme Q10 on prevention of myringosclerosis? Experimental study with rats. Braz J Otorhinolaryngol. 2013;79:293. doi:10.5935/1808-8694.20130053

We explored the potential benefits of coenzyme Q10 in preventing myringosclerosis, a condition that affects the eardrum, by conducting an experiment with healthy female rats. In our study, we set up four different groups of rats, ensuring that some received no treatment, while others were given oral coenzyme Q10, topical saline solution, or topical coenzyme Q10 directly on the eardrum.

After treating them for 15 days, we examined their tympanic membranes using a method called otomicroscopy. Unfortunately, we found no significant difference in myringosclerosis formation among the groups, particularly when comparing the untreated group with those that received coenzyme Q10—both orally and topically.

While the topical coenzyme Q10 group did show some initial complications, such as otitis, which led to their exclusion from the study, the overall results indicated that coenzyme Q10 does not effectively reduce the risk of developing myringosclerosis in the tested conditions. It’s important to be transparent about these findings, as they suggest that coenzyme Q10 might not be the answer for preventing this specific ear condition after all.

9.5

Helps with infections

Most Useful Review

Coenzyme Q10 has helped me with migraines and has improved my immune function by enhancing oxygen absorption in cells. This supplement has also aided my body in combating external infections.

Menopause details

Sandhir R, Sethi N, Aggarwal A, Khera A. Coenzyme Q10 treatment ameliorates cognitive deficits by modulating mitochondrial functions in surgically induced menopause. Neurochem Int. 2014;74:16. doi:10.1016/j.neuint.2014.04.011

Based on 3 Researches

CoQ10 enhances cognitive function

We aimed to understand how cognitive decline occurs after menopause, particularly due to decreased ovarian function and estrogen. To explore this, we studied the effects of Coenzyme Q10 (CoQ10), a substance known for its potential health benefits, on cognitive impairment in post-menopausal mice.

After four weeks of ovariectomy, which simulates menopause, we observed significant cognitive deficits in the mice, as measured by popular tests like the Morris water maze and elevated plus maze. However, when we gave these mice CoQ10 daily for four weeks, we saw a remarkable improvement in their cognitive functions.

We also investigated the underlying reasons for this decline by looking at mitochondrial functions in the brain. Our findings revealed that the activity of several key components of the mitochondrial electron transport chain was significantly reduced in the ovariectomized mice. These changes were associated with increased oxidative stress, indicated by high levels of reactive oxygen species and protein damage.

Interestingly, CoQ10 supplementation helped mitigate these mitochondrial dysfunctions and oxidative stress, leading to improved cognitive performance in the mice. Therefore, it seems that CoQ10 has a positive effect in addressing cognitive decline related to menopause by supporting mitochondrial health and reducing oxidative stress.

9.5

Blood pressure relief

Most Useful Review

I have been taking blood pressure medication for three years and successfully managed it with exercise and nutritional supplements. After starting CoQ10, my blood pressure dropped by 5-10 points and remained stable. It significantly reduced gum inflammation and strengthened my teeth. At 55, my skin has become soft and hydration has improved, making it ideal for those concerned about skin and blood pressure during menopause. I encourage everyone to care for their CoQ10 and stay healthy.

Mild Cognitive Impairment details

Cognitive improvement with CoQ10 My father has Parkinson's and now dementia, and his condition was rapidly deteriorating until he started taking CoQ10. His cognition has noticeably improved, and it's as though we have our father back. Even if this product only halts the decline temporarily, we are very grateful for this time together.

Stroke details

CoQ10 aids stroke recovery

Mojaver A, Khazaei M, Ahmadpanah M, Zarei M, Soleimani Asl S, et al. Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study. Neurol Res. 2025. doi:10.1080/01616412.2025.2470712

We investigated the potential benefits of coenzyme Q10 (CoQ10) supplementation in patients recovering from acute ischemic stroke. In this double-blind, randomized placebo-controlled study, fifty hospitalized patients were divided into two groups; one received 600 mg of CoQ10 daily for 30 days, while the other received a placebo starting 24 hours post-stroke.

Our findings revealed notable improvements among those taking CoQ10. The group supplemented with CoQ10 showed significant reductions in harmful substances linked to oxidative stress, such as malondialdehyde (MDA) and inflammatory interleukin-6 (IL-6). Additionally, we observed increases in beneficial antioxidants, including superoxide dismutase (SOD) and brain-derived neurotrophic factor (BDNF), suggesting that CoQ10 may aid in neuroprotection and recovery after a stroke.

While some biomarkers did not show significant change, the overall results suggest that CoQ10 could be a valuable addition to rehabilitation programs for stroke patients, potentially improving recovery outcomes.

9.5

Prevents heatstroke

Most Useful Review

I find Coenzyme Q10 essential for surviving summer in Japan as it helps with my weak autonomic nervous system. Taking it after breakfast has prevented heatstroke during my commutes, which I previously suffered from.

Tinnitus details

Sleep has greatly improved for my mother, aged 58, who has endured ten years of fatigue and tinnitus. After discovering coenzyme Q10, her energy levels have soared without the constant tiredness. She now feels powerful and revitalised.

Anemia details

Lynch RE, Hammar SP, Lee GR, Cartwright GE. The anemia of vitamin E deficiency in swine: an experimental model of the human congenital dyserythropoietic anemias. Am J Hematol. 1977;2:145.

Based on 7 Researches

Coenzyme Q10 aids anemia treatment

We explored the characteristics of anemia caused by vitamin E deficiency in pigs to see how it might serve as a model for human congenital dyserythropoietic anemia (CDA). In this study, we found that the main issue in these pigs was ineffective erythropoiesis, similar to what some humans experience with CDA.

Strikingly, we observed increases in certain erythrocyte enzymes in these pigs, paralleling changes noted in CDA patients. In the animals, distinctive structural alterations similar to those seen in human cases were present in normoblasts, the precursors to red blood cells.

A notable finding was that administering coenzyme Q10, alongside vitamin E, led to a complete hematologic response in the pigs. This suggests that coenzyme Q10 could play a significant role in addressing anemia related to vitamin E deficiency. However, the partial response noted after adjusting the diet indicates that there may be more factors at play in this disorder’s development.

Overall, coenzyme Q10 appears to have a beneficial impact on treating anemia in this swine model, indicating potential avenues for further research in human applications.

8.8

Increased energy

Most Useful Review

Doctors Best High Absorption coQ10 has significantly boosted my energy levels. I have thalassemia anemia, which isn't treatable with medications, but this product is quite affordable and helps me a great deal.

Anxiety details

Q10 reduces heat stress-induced anxiety

Mahmoudi J, Kazmi S, Vatandoust S, Athari SZ, Sadigh-Eteghad S, et al. Coenzyme Q10 and vitamin E alleviate heat stress-induced mood disturbances in male mice: Modulation of inflammatory pathways and the HPA axis. Behav Brain Res. 2025;476:115259. doi:10.1016/j.bbr.2024.115259

We explored the effects of coenzyme Q10 (Q10) on anxiety symptoms caused by heat stress in male mice. The study involved several groups of mice, exposing them to high temperatures while treating them with either Q10, vitamin E, or a combination of both for two weeks. We assessed their mood through various tests that measure anxiety and despair behavior, including the forced swimming test and the elevated plus maze.

Our findings indicated that both Q10 and vitamin E had significant anxiolytic traits on the mice affected by heat stress. This means that these treatments effectively reduced anxiety levels. Not only did they show positive changes in behavior during the anxiety tests, but we also observed a notable decrease in stress hormone levels. Additionally, the treatments seemed to lower inflammatory markers in the brain, suggesting a possible pathway for their effectiveness.

In summary, incorporating Q10 into treatment strategies could offer an innovative way to address anxiety, especially in situations involving environmental stressors like extreme heat. We advocate further investigation into how these findings might translate into human applications, particularly for managing stress-induced anxiety.

Increased energy

Most Useful Review

Energy charge! I bought this dietary supplement to enhance my performance, especially after covid. On the third week, I felt more energetic, waking up easily with one alarm. My productivity improved, and I felt less fatigued. My anxiety diminished and my mood stabilised. My light tachycardia is gone, and my recovery from gym sessions has improved. Q10 is essential for everyone, as its production decreases with age—suggesting it should be supplemented. I hope this review helps!

Arteriosclerosis details

CoQ10 influences cholesterol management

Based on 15 Researches

Allen RM, Vickers KC. Coenzyme Q10 increases cholesterol efflux and inhibits atherosclerosis through microRNAs. Arterioscler Thromb Vasc Biol. 2014;34:1795. doi:10.1161/ATVBAHA.114.303741

We explored the effects of a popular supplement called Coenzyme Q10 (CoQ10) on atherosclerosis, specifically how it influences cholesterol levels in macrophages. Through recent research, we found that CoQ10 inhibits c-Jun expression and hinders the activity of a protein complex known as AP-1. This complex typically boosts the production of a microRNA called miR-378.

miR-378 is significant because it directly targets ABCG1, a transporter that helps in the removal of cholesterol from cells. When the suppression of miR-378 is lifted, cholesterol efflux increases, providing a protective effect against atherosclerosis in mice. This study emphasizes the connections between CoQ10, cholesterol management, and overall heart health.

By understanding these connections better, we can appreciate the potential of CoQ10 as a supportive treatment for conditions like atherosclerosis. The findings open up interesting possibilities for future research and practical applications in addressing heart disease.

8.8

Improves circulation

Most Useful Review

This product has been repurchased for my husband, who suffers from high blood pressure. Coenzyme Q10 can help prevent arteriosclerosis and enhance body circulation.

Bruise details

Improved bruise condition

I ordered this for my mother, who has issues with blood vessels and gets bruises easily. After taking it with vitamin C, her condition improved, along with decreased weather sensitivity and stabilised blood pressure. Studies show that Coenzyme Q10 can reduce inflammation in blood vessels and is crucial for conditions like diabetes and cancer. My mother will continue this supplement.

Cancer details

Hussein Z, Michel HE, El-Naga RN, El-Demerdash E, Mantawy EM. Coenzyme Q10 ameliorates cyclophosphamide-induced chemobrain by repressing neuronal apoptosis and preserving hippocampal neurogenesis: Mechanistic roles of Wnt/ β-catenin signaling pathway. Neurotoxicology. 2024;105:21. doi:10.1016/j.neuro.2024.08.003

Based on 5 Researches

CoQ10 mitigates chemobrain effects

We explored the potential benefits of Coenzyme Q10 (CoQ10) on cancer patients dealing with a condition commonly referred to as "Chemobrain," which is associated with treatment using the chemotherapy drug cyclophosphamide (CYP). In our study, male rats were given a daily dose of CoQ10 for ten days, while they also received a single dose of CYP to model the effects of chemotherapy on cognition and motor skills.

The findings were promising. CoQ10 not only helped counteract cognitive and motor dysfunctions triggered by CYP but also showed significant neuroprotective effects. Behavioral tests demonstrated improvements, and histopathological analysis confirmed that CoQ10 reduced brain damage linked to oxidative stress caused by CYP. This micronutrient effectively restored levels of the antioxidant enzyme catalase and lowered harmful substances like malondialdehyde.

Furthermore, CoQ10 appeared to inhibit neuronal apoptosis, or cell death, by balancing expressions of key proteins involved in the process. It supported neurogenesis in the hippocampus by increasing important growth factors. Most notably, CoQ10 activated the Wnt/β-catenin signaling pathway, which is crucial for brain health and development.

Overall, our study highlights how CoQ10 may offer a multi-faceted approach to mitigating the adverse effects of chemotherapy on cognitive function, bolstering both brain protection and regeneration.

9.5

Supports immunity

Most Useful Review

This powerful supplement is highly recommended by doctors to boost the immunity of cancer patients.

Diabetes details

I believe it helped me avoid type 2 diabetes and heart disease! My family has a history of these conditions, and at 48, I was 80 pounds overweight. While my cholesterol and blood sugar were high, I've now lost over 40 pounds, and my levels are fantastic. I attribute this improvement to taking 100mg of Coenzyme Q10 twice a day while managing my weight.

Erectile Dysfunction details

Safarinejad MR. Safety and efficacy of coenzyme Q10 supplementation in early chronic Peyronie's disease: a double-blind, placebo-controlled randomized study. Int J Impot Res. 2010;22:298. doi:10.1038/ijir.2010.20

CoQ10 improves erectile function

We conducted a randomized, double-blind, placebo-controlled study to investigate the effectiveness of coenzyme Q10 (CoQ10) in treating erectile dysfunction (ED) in men diagnosed with early chronic Peyronie's disease (PD). A total of 186 participants took part, with half receiving 300 mg of CoQ10 daily and the other half receiving a placebo over a 24-week period.

Throughout the study, we regularly assessed various factors such as erectile function, pain during erection, plaque volume, and penile curvature. We also used a patient satisfaction questionnaire to gauge overall treatment satisfaction.

After 24 weeks, we observed significant improvements in erectile function and reduced pain for those taking CoQ10. Specifically, the CoQ10 group showed a notable increase in mean erectile function scores and a decrease in plaque size and penile curvature. In contrast, patients in the placebo group experienced disease progression more frequently.

Overall, our study suggests that CoQ10 supplements may effectively reduce symptoms related to ED in men suffering from Peyronie's disease. This potential advancement could offer hope for those still seeking effective treatments for this condition.

9.5

Erectile dysfunction relief

Most Useful Review

I have repurchased this product multiple times as my heart felt uncomfortable due to erectile dysfunction. After taking it, I have noticed significant improvement.

Heart Attack details

Singh RB, Fedacko J, Mojto V, Pella D. Coenzyme Q10 Modulates Remodeling Possibly by Decreasing Angiotensin-Converting Enzyme in Patients with Acute Coronary Syndrome. Antioxidants (Basel). 2018;7. doi:10.3390/antiox7080099

Coenzyme Q10 aids heart recovery

We investigated how coenzyme Q10 might help with heart function after a heart attack, particularly focusing on its role in heart remodeling. In a well-structured study involving 55 patients with left ventricular dysfunction following an acute myocardial infarction, we compared the effects of coenzyme Q10 to a placebo over a 24-week period.

Through careful measurements using echocardiography, we observed notable improvements in the walls of the heart and overall heart mass for those taking coenzyme Q10. Specifically, the thickness of the heart walls decreased, and the left ventricular mass was reduced more significantly than in those receiving the placebo.

Additionally, coenzyme Q10 appeared to maintain heart shape and prevent worsening of heart function compared to the placebo group. Our results also highlighted a significant drop in angiotensin-converting enzyme (ACE) levels in the coenzyme Q10 group, suggesting beneficial effects on heart remodeling and function during recovery from a heart attack.

9.5

Cessation of arrhythmia

Most Useful Review

After my mother suffered a heart attack, she began taking Coenzyme Q10. Initially at 60-90 mg daily, her arrhythmia attacks ceased after 5 months. For two years, she has continued with 100 mg daily, resulting in noticeable health improvements. I started taking Q10 at 50 mg daily, feeling more energetic and noticing improved gum health. This product has transformed our lives, and friends have also begun taking it based on our experience.

High Cholesterol details

Liu Z, Tian Z, Zhao D, Liang Y, Dai S, et al. Effects of Coenzyme Q10 Supplementation on Lipid Profiles in Adults: A Meta-analysis of Randomized Controlled Trials. J Clin Endocrinol Metab. 2022;108:232. doi:10.1210/clinem/dgac585

Based on 12 Researches

CoQ10 lowers cholesterol levels

We delved into the effects of coenzyme Q10 (CoQ10) supplementation on cholesterol levels in adults to determine how it can influence lipid profiles. Through a thorough meta-analysis of fifty randomized controlled trials involving nearly 2800 participants, we explored its potential benefits for reducing cholesterol levels effectively.

Our findings indicated that CoQ10 supplementation significantly lowered levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG), while simultaneously increasing high-density lipoprotein cholesterol (HDL-C). This effect was particularly pronounced at a dosage of 400 to 500 mg per day, which was shown to produce the best results in terms of reducing TC.

Overall, the study provided strong evidence that CoQ10 could be a valuable ally in managing high cholesterol, helping to achieve a healthier lipid profile in adults. This research sheds light on a promising dietary supplement that might assist individuals seeking to improve their cholesterol levels effectively.

9.5

Energy production boost

Most Useful Review

BEST FRIENDS! Coenzyme Q-10 helps produce energy in the body and acts as an antioxidant. CoQ10 controls high blood pressure and maintains energy metabolism, aiding in heart health and even supporting the immune system. It is absorbed better with fats!

Hypothyroidism details

Pandolfi C, Ferrari D, Stanic I, Pellegrini L. [Circulating levels of CoQ10 in hypo- and hyperthyroidism]. Minerva Endocrinol. 1994;19:139.

Based on 4 Researches

CoQ10 levels and thyroid health

We evaluated the levels of Coenzyme Q10 (CoQ10) in patients with hypothyroidism and hyperthyroidism to understand its role in thyroid health. The study included participants from both groups, as well as a control group without thyroid issues, ensuring that no subjects had other cardiovascular or metabolic diseases that could interfere with the results.

Our findings showed that hypothyroid patients had a higher average level of CoQ10 in their blood compared to those with hyperthyroidism. Specifically, hypothyroid patients showed levels of 0.97 mcg/ml, while hyperthyroid patients had only 0.51 mcg/ml, with the control group at 0.73 mcg/ml. This suggests that patients with hypothyroidism may have a greater prevalence of higher CoQ10 levels.

However, we found that the differences were not enough to clearly separate those with normal thyroid function from those with either hypothyroidism or hyperthyroidism. While there is a noted inverse relationship between CoQ10 levels and certain thyroid hormones, this indicates that CoQ10 alone may not provide significant benefits for those specifically dealing with hypothyroidism. More research—especially longitudinal studies—is needed to see how treatment and therapy could potentially affect CoQ10 levels and overall thyroid health in these patients.

9.5

Supports thyroid recovery

Most Useful Review

I have bought this product multiple times for heart health. My husband has taken it for over five years, witnessing substantial improvement in his heart condition. I started it this year for my hypothyroidism and hyperlipidemia, and it appears to aid in restoring thyroid function while protecting cardiovascular health.

Low Libido details

Sexual desire increased

Very good! The quality is excellent and it has increased my sexual desire, something I've noticed at the age of 37. However, the pill is quite large and challenging to swallow.

Obesity details

Jin M, Zou T, Huang H, Chen M, Zou H, et al. The Effect of Coenzyme Q10 Supplementation on Bile Acid Metabolism: Insights from Network Pharmacology, Molecular Docking, and Experimental Validation. Mol Nutr Food Res. 2024;68:e2400147. doi:10.1002/mnfr.202400147

Based on 6 Researches

CoQ10 affects bile acid metabolism

We explored how Coenzyme Q10 (CoQ10) supplementation affects bile acid metabolism and its potential implications for obesity. The study focused on mice fed a high-fat diet to simulate conditions related to obesity and glycolipid disorders. By utilizing advanced techniques, including Ultra-Performance Liquid Chromatography-tandem Mass Spectrometry, we assessed the impact of CoQ10 treatment.

Our findings revealed that CoQ10 not only helped reverse the decrease in serum and colonic bile acid levels associated with a high-fat diet but also altered the bile acid profile positively. We identified seventeen potential targets for CoQ10's action in bile acid metabolism, with six key targets being especially vital to the observed effects. Notably, CoQ10 showed a strong binding affinity to five of these key targets, including the farnesoid X receptor (FXR) and Takeda G-protein coupled receptor 5 (TGR5).

Through this research, we gained valuable insights into how CoQ10 can potentially regulate bile acid metabolism. These findings provide a new perspective on utilizing CoQ10 for enhancing metabolic health, particularly concerning obesity and related metabolic disorders.

8.8

Improved energy levels

Most Useful Review

Coenzyme Q10 is a compound produced by the liver that stimulates ATP production, the body's primary energy source. Its levels decline with age, necessitating additional intake, especially for older individuals. I've taken it for five days and noticed more energy, improved mood, and enhanced productivity. I recommend this excellent supplement from Doctor's Best!

Osteoporosis details

CoQ10 mitigates SCI-induced osteoporosis

Based on 9 Researches

Zhang XX, Qian KJ, Zhang Y, Wang ZJ, Yu YB, et al. Efficacy of coenzyme Q10 in mitigating spinal cord injury-induced osteoporosis. Mol Med Rep. 2015;12:3909. doi:10.3892/mmr.2015.3856

We aimed to understand how coenzyme Q10 (CoQ10) might help combat osteoporosis caused by spinal cord injuries (SCI). In our study, we induced SCI in rats by surgically transecting the spinal cord at the T10-12 level and began treating them with CoQ10 daily, starting just 12 hours after the procedure. This treatment lasted for 10 consecutive days, allowing us to evaluate its effects on bone health.

Our findings showed that CoQ10 effectively prevented the loss of bone density and mineral content typically seen in rats following SCI. We observed a notable reduction in harmful substances that damage bone, alongside an increase in protective factors. Furthermore, CoQ10 appeared to reduce inflammation in the affected rats, which is crucial since inflammation can worsen bone health.

We also examined the genetic changes associated with bone formation and found that CoQ10 backup significantly restored the balance between bone-building and bone-resorbing cells. Overall, our study suggests that CoQ10 can be a helpful intervention in mitigating osteoporosis linked to spinal cord injuries, offering hope for future treatments in similar conditions.

8.8

Active preparation

Most Useful Review

Excellent! The preparation for osteoporosis and arthrosis protocols is very active, although it is generally used after the age of 35.

Swollen Lymph Nodes details

Effective gum treatment

I have battled periodontitis for a decade, with gums perpetually swollen despite rigorous oral hygiene. I began taking Coenzyme Q10 two months ago at 100 mg twice a day, and I noticed improvement from the second day. My shaky tooth has firmed up within a week, and I haven't experienced any infections since I started this supplement. Additionally, my palpitations have significantly decreased. I’m truly grateful to have discovered this!

Ulcer details

Farsi F, Ebrahimi-Daryani N, Barati M, Janani L, Karimi MY, et al. Effects of coenzyme Q10 on health-related quality of life, clinical disease activity and blood pressure in patients with mild to moderate ulcerative colitis: a randomized clinical trial. Med J Islam Repub Iran. 2021;35:3. doi:10.47176/mjiri.35.3

Based on 12 Researches

CoQ10 improves UC symptoms

We explored the effects of coenzyme Q10 (CoQ10) on patients suffering from ulcerative colitis (UC), a condition characterized by chronic inflammation of the digestive tract. In this randomized clinical trial, 88 individuals were split into two groups: one received 200 mg of CoQ10 daily, while the other received a placebo, all over the course of 8 weeks.

Our findings were promising. We observed significant improvements in the health-related quality of life and a reduction in disease activity among those who took CoQ10. Specifically, scores measuring disease severity dropped noticeably, and both systolic and diastolic blood pressure decreased for participants on CoQ10. Conversely, there were no noteworthy changes in body measurements between the groups, indicating that the drug's influence was more about managing symptoms than affecting body weight or composition.

Overall, this study suggests that CoQ10 might be a valuable addition to treatment strategies for UC, enhancing patient well-being and potentially improving overall health outcomes. We advocate for further research to fully understand the benefits of CoQ10 in managing ulcerative colitis.

8.8

Reduced ulcer symptoms

Most Useful Review

I recommend Coenzyme Q10 for heart health. The body may lack this coenzyme after 20 years, leading to a decline. It acts as an antioxidant and aids energy metabolism. I took it regularly after 40, but needed to increase my dose for energy and reduced heart discomfort. It is advisable to avoid taking it during an ulcer flare-up. This product from Doctor's Best is affordable and easy to swallow. I felt energised after increasing the dosage.

Asthma details

Gazdik F, Gvozdjakova A, Horvathova M, Weissova S, Kucharska J, et al. Levels of coenzyme Q10 in asthmatics. Bratisl Lek Listy. 2002;103:353.

Based on 5 Researches

CoQ10 levels low in asthma

We investigated how coenzyme Q10 (CoQ10), an antioxidant, influences individuals with asthma. In our study, we enrolled 56 patients with asthma and compared them to a control group of 25 healthy volunteers. This approach allowed us to assess the differences in antioxidant levels, particularly focusing on CoQ10, alpha-tocopherol, beta-carotene, and malondialdehyde (a marker of oxidative stress).

Our findings revealed that both CoQ10 and alpha-tocopherol levels were significantly lower in asthma patients compared to healthy individuals. Interestingly, while the level of malondialdehyde was higher in asthmatics, it did not reach statistical significance. We also found that the concentration of CoQ10 had a positive correlation with alpha-tocopherol levels, suggesting that they may work together in the body's defense against oxidative stress.

Ultimately, these results suggest that having lower levels of CoQ10 might contribute to an imbalance in antioxidants among asthma patients. Though the study highlights a potential link, it is crucial to note that we did not demonstrate a direct therapeutic benefit as we did not isolate CoQ10's effects from other treatments. Future research could further explore the role of CoQ10 supplementation in managing asthma symptoms.

9.5

Better asthma control

Most Useful Review

This has helped in keeping my asthma under control, so I don't need my inhalers as frequently.

Chronic Cough details

I really want to eat a lifetime supply of this! I used to suffer from chronic fatigue, but after taking CoQ10 for just 2-3 days, I felt a surge of energy. I wished to consume it continuously, like in Korea. It’s expensive back home, and I don’t want to deal with that. This supplement has been a lifesaver for chronic fatigue—I would rate it a million stars!

Frozen Shoulder details

Since taking Q10 100 Mg, my muscles and shoulder joints, which were suffering from frozen shoulder due to statin use, have improved significantly. I can now move normally again.

Irritable Bowel Syndrome details

Life-changing effects

The effect is instant! For three weeks, I've taken two capsules (200 mg) after breakfast, following the advice in “Ever Tired” on chronic fatigue syndrome. On the first day, I recognised the stark difference between being "tired" and having "no strength." For years, I'd lived with constant muscle fatigue, resembling post-workout exhaustion. Now, I feel energised, even when fatigued, and can manage daily tasks without collapsing into bed. My clarity of thought has sharpened, and I'm more confident driving after a long day. Bonus: my complexion has improved, and my skin is more hydrated. I ordered more and hope my experience aids others, especially where chronic fatigue syndrome treatment is lacking.

Premenstrual Syndrome details

Excellent! My health has improved noticeably within two to three weeks of starting the supplement. Perhaps it’s coincidental, but managing premenstrual syndrome has become much easier for me. Overall, my bodily condition is impressive, and I appreciate the modest price. I also agree it pairs well with Omega-3.

Psoriasis details

Kocic H, Damiani G, Stamenkovic B, Tirant M, Jovic A, et al. Dietary compounds as potential modulators of microRNA expression in psoriasis. Ther Adv Chronic Dis. 2019;10:2040622319864805. doi:10.1177/2040622319864805

Coenzyme Q10 and psoriasis effects

We examined the role of coenzyme Q10 in psoriasis treatment, focusing on its effects on microRNAs. The research highlighted the complex relationship between dietary compounds and the management of psoriasis, particularly through the modulation of specific microRNAs that are known to be implicated in the condition.

Among the findings, it was noted that the expression of miR-125b, which is often downregulated in psoriasis, can be restored by coenzyme Q10. This suggests a potential benefit of coenzyme Q10 in contributing to the overall balance of microRNAs in psoriasis.

However, the evidence remains part of a broader discussion about dietary influences on psoriasis, rather than a definitive conclusion about coenzyme Q10's standalone effectiveness. Therefore, while there is some promising data, we cannot assert that coenzyme Q10 works as a singular treatment for psoriasis without further comprehensive studies.

8.8

Positive results

Most Useful Review

Psoriasis help so far, so good...

Alzheimer details

Ubiquinol may combat Alzheimer's effects

Llanos-González E, Sancho-Bielsa FJ, Frontiñán-Rubio J, Rabanal-Ruíz Y, García-Carpintero S, et al. Spatial and Temporal Protein Modules Signatures Associated with Alzheimer Disease in 3xTg-AD Mice Are Restored by Early Ubiquinol Supplementation. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12030747

We explored the effects of ubiquinol, a form of coenzyme Q10, on Alzheimer's disease through a model using 3xTG-AD mice. Our research aimed to understand how disrupted protein modules in the brain correlate with the progression of Alzheimer's, particularly in terms of oxidative stress and protein regulation.

By employing advanced techniques like MALDI-MSI and functional bioinformatics, we examined how these protein modules are altered based on the age of the mice. We found significant deregulation in specific protein modules related to oxidative stress and metabolism, especially in the hippocampus of younger mice (6 months old) and in the cortical regions of older mice (12 months old). This suggests that early intervention might be crucial to address these changes.

Remarkably, we observed that introducing ubiquinol at an early stage could help restore these protein modules back to a healthier state. This is exciting because it means dietary adjustments, particularly an increase in ubiquinol, could be beneficial in preventing the progression of Alzheimer’s symptoms, both in mice and potentially in humans.

Our findings not only highlight the impact of early dietary intervention but also reinforce the significance of exploring coenzyme Q10 and its benefits for brain health as we age. We believe these insights could pave the way for promising new strategies to combat Alzheimer's disease.

Improved mood

Most Useful Review

Coenzyme Q10 is a vital compound produced by the liver, crucial for energy production (ATP). It declines with age, often leading to health issues. Daily requirements vary: around 50 mg for the young and up to 300 mg for the older population. Supplements can help. After five days on Coenzyme Q10, I noticed an uplift in my mood, increased energy, and improved sleep. It's an excellent supplement, particularly beneficial for managing Alzheimer, and I highly recommend it. Doctor's Best offers great value!

Arthritis details

Nachvak SM, Alipour B, Mahdavi AM, Aghdashi MA, Abdollahzad H, et al. Effects of coenzyme Q10 supplementation on matrix metalloproteinases and DAS-28 in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled clinical trial. Clin Rheumatol. 2019;38:3367. doi:10.1007/s10067-019-04723-x

Based on 15 Researches

CoQ10 shows promise for RA

We explored the effects of Coenzyme Q10 (CoQ10) supplementation on rheumatoid arthritis (RA) patients in a well-structured study. Fifty-four individuals diagnosed with RA were divided into two groups: one received 100 mg of CoQ10 daily, while the other group received a placebo for two months. This randomized and double-blind setup helped ensure that the findings would be credible and free from bias.

Our findings revealed some noteworthy changes in the CoQ10 group. There was a significant reduction in serum levels of matrix metalloproteinase-3 (MMP-3), which is linked to inflammation and tissue remodeling, alongside improvements in clinical indicators like swollen joint count and the disease activity score (DAS-28). Essentially, participants taking CoQ10 experienced a decrease in pain levels and tenderness in their joints, suggesting that CoQ10 may offer additional benefits for managing RA symptoms.

However, the study also showed slight improvements in the placebo group, indicating that factors like natural variability and placebo effects could play a role in treatment outcomes. While CoQ10 touted some advantages over the placebo, the reduction in MMP-3 levels signifies a potentially therapeutic area worth further exploration.

In conclusion, CoQ10 may serve as a complementary approach for those dealing with the challenges of rheumatoid arthritis, supporting both clinical symptoms and biomarkers of inflammation.

8.8

Joint improvement

Most Useful Review

I will take more! I decided to enhance my knowledge about what is necessary for health as I age. I chose Q10 Dr Best after researching various brands and customer feedback. I take one tablet daily, along with Omega tablets. Within a month, my arthritis pain has lessened significantly, with no morning stiffness or swelling. For the first time in ten years, I could wear my wedding ring comfortably. I believe the combination is effective, so I've ordered more for my parents and myself.

Autoimmune Disorder details

Blanco LP, Pedersen HL, Wang X, Lightfoot YL, Seto N, et al. Improved Mitochondrial Metabolism and Reduced Inflammation Following Attenuation of Murine Lupus With Coenzyme Q10 Analog Idebenone. Arthritis Rheumatol. 2020;72:454. doi:10.1002/art.41128

Based on 14 Researches

Idebenone improves lupus symptoms

We explored the potential benefits of idebenone, a synthetic analog of coenzyme Q10, in treating autoimmune disorders, specifically lupus, in mouse models. By administering idebenone to mice with lupus for eight weeks, we aimed to investigate its impact on disease activity and organ damage.

Our findings showed that idebenone led to a significant reduction in disease severity. Mice that received idebenone exhibited lower mortality rates and improvements in kidney function, indicated by reduced glomerular inflammation and lower levels of certain inflammatory markers. The treatment also minimized the production of proinflammatory cytokines and enhanced mitochondrial metabolism.

Besides benefiting the kidneys, idebenone diminished markers of inflammation throughout the body, which is crucial since lupus often results in systemic damage. Importantly, we noticed that idebenone improved overall metabolism in these mice without causing obvious side effects.

This research supports the idea that modulating mitochondrial function can be a promising therapeutic strategy for managing lupus, opening the door for future studies on its effectiveness in humans.

9.5

Increased energy levels

Most Useful Review

I truly want to enjoy life fully. Suffering from chronic fatigue, I discovered CoQ10, and within just a few days, I experienced a surge in energy. I no longer feel exhausted, and I highly recommend this to anyone with chronic fatigue!

Back Pain details

Improved energy levels

After a month of taking the coenzyme on my husband’s recommendation, we noticed significant changes. I started waking up before the alarm, feeling refreshed. My back pain and apathy lessened. Upon stopping the supplement after two months, the apathy returned, so we’re taking it in cycles. I find it easier to consume by pouring it into a spoon, despite the peppery taste.

Blurred Vision details

Improved quality of life

Coenzyme Q-10, often regarded as the battery, has significantly enhanced my 83-year-old mother's well-being. Despite her hypertension and heart issues, after commencing Q-10 and dietary supplements, she’s exhibited remarkable improvements. Her energy levels have soared, and while her blood pressure remains, the systolic figures have stabilised notably. This ubiquinone is integral to cellular energy production and helps mitigate issues like hypoxia and shortness of breath. Overall, her quality of life has greatly improved! We advocate Q-10 for older adults and active individuals, especially those on statins for cholesterol control. I hope our review assists others in making informed choices.

Fibromyalgia details

Fernández-Araque A, Verde Z, Torres-Ortega C, Sainz-Gil M, Velasco-Gonzalez V, et al. Effects of Antioxidants on Pain Perception in Patients with Fibromyalgia-A Systematic Review. J Clin Med. 2022;11. doi:10.3390/jcm11092462

Coenzyme Q10 alleviates pain

We examined the effectiveness of coenzyme Q10 in alleviating pain for those suffering from fibromyalgia. Through a systematic review of multiple studies, we found that antioxidant supplementation, specifically involving coenzyme Q10, plays a significant role in reducing pain perception among patients.

Nine out of the seventeen studies we reviewed indicated that antioxidant supplements were effective in decreasing pain. Notably, those studies that maintained a supplementation duration of six weeks or longer reported benefits for 80% of participants. This suggests that consistent intake of coenzyme Q10 might be particularly beneficial for fibromyalgia patients, potentially making a noticeable difference in their daily lives.

Despite these promising findings, we also recognize the importance of further research to explore the impact of other antioxidants, like turmeric and extra virgin olive oil. The study calls for more standardized approaches in terms of dosages and treatment duration, which would enable us to better understand the full spectrum of effects antioxidants can have on fibromyalgia.

9.5

Improves symptoms

Most Useful Review

CoQ10 is vital for energy production and acts as an antioxidant. It’s particularly important if you’re on statins, as they reduce CoQ10 levels. I've experienced good results with this supplement for fibromyalgia, chronic fatigue syndrome, and other ailments. I highly recommend this product for its effectiveness and affordability, especially for people over 50.

Gastritis details

CoQ10 improves gastritis treatment

Rahmani A, Abangah G, Moradkhani A, Hafezi Ahmadi MR, Asadollahi K. Coenzyme Q10 in combination with triple therapy regimens ameliorates oxidative stress and lipid peroxidation in chronic gastritis associated with H. pylori infection. J Clin Pharmacol. 2015;55:842. doi:10.1002/jcph.508

We investigated the potential benefits of coenzyme Q10 (CoQ10) in treating chronic gastritis linked to H. pylori infection. In our clinical trial, we randomly divided 100 participants into two groups: one received a standard triple therapy regimen, while the other received the same treatment with the addition of CoQ10.

Our findings were promising. We observed a significant decrease in inflammation scores among those who took CoQ10 alongside the triple therapy compared to those who only received the base treatment. Additionally, we noted that the antioxidant levels in the CoQ10 group improved notably over the duration of the study. Specifically, the total antioxidant capacity and glutathione peroxidase levels were significantly better in the intervention group than at the start of the study.

Combining CoQ10 with standard treatment appeared to effectively address both mucosal inflammation and oxidative stress in patients suffering from chronic gastritis. This suggests a compelling advantage to including CoQ10 in treatment regimens for such conditions.

Metabolic improvement

Most Useful Review

Coenzyme has significantly improved my metabolic processes and reduced my cravings for high-calorie foods, making it beneficial for weight loss. Additionally, I advise against taking it if you have gastritis or any erosive gastrointestinal issues, as it should not be consumed on an empty stomach or at night. Overall, I highly recommend this remarkable supplement.

Knee Pain details

CoQ10 alleviates knee osteoarthritis

Lee J, Hong YS, Jeong JH, Yang EJ, Jhun JY, et al. Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines. PLoS One. 2013;8:e69362. doi:10.1371/journal.pone.0069362

We explored the impact of Coenzyme Q10 (CoQ10) on knee pain and cartilage health using a rat model of osteoarthritis (OA). Our investigation involved inducing OA in rats through an injection of monosodium iodoacetate into the knee joint. Subsequently, we administered CoQ10 orally starting on the fourth day after the injection.

Pain severity was evaluated by assessing tactile sensitivity, and we also examined the state of cartilage by measuring its thickness and proteoglycan levels. Notably, CoQ10 demonstrated a significant reduction in pain, indicated by increased pain withdrawal thresholds. We observed that the treatment led to a decrease in cartilage degeneration as well.

Moreover, CoQ10 lowered the levels of several inflammatory markers associated with OA, including matrix metalloproteinase-13 and various interleukins. Based on our findings, we conclude that CoQ10 is a promising option for alleviating pain and protecting cartilage in individuals suffering from osteoarthritis.

9.5

Reduced leg pain

Most Useful Review

I take pills for cholesterol that cause leg pain. This supplement, taken as one capsule each morning, almost entirely prevents the discomfort. After trying to stop, the pain returned a few days later, confirming its effectiveness.

Migraine details

Dahri M, Tarighat-Esfanjani A, Asghari-Jafarabadi M, Hashemilar M. Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers. Nutr Neurosci. 2019;22:607. doi:10.1080/1028415X.2017.1421039

Based on 32 Researches

CoQ10 improves migraine symptoms

We conducted a study to see how coenzyme Q10 (CoQ10) supplementation impacts migraine symptoms and inflammation. This randomized double-blind trial involved 45 non-menopausal women with episodic migraines.

Participants took either 400 mg/day of CoQ10 or a placebo for three months, while continuing their usual migraine medications. We observed a significant reduction in migraine frequency, severity, and duration in the CoQ10 group.

Additionally, CoQ10 levels and inflammatory markers showed some changes, specifically a reduction in certain proteins linked to inflammation. However, not all markers responded positively, indicating some limited effectiveness.

9.5

Migraine attacks nearly absent

Most Useful Review

This product is effective; after regular use, my migraine attacks have almost disappeared. I feel energised and overall it has greatly improved my wellbeing.

Polycystic Ovary Syndrome details

Good and effective. It reduces wrinkles and beautifies my skin, improves fatigue, helps relieve migraines, supports sarcopenia, and manages my polycystic ovary syndrome. It has even proven beneficial for Parkinson's disease.

Prostate Cancer details

Coenzyme Q10 effects on prostate cancer

Likely Ineffective

Based on 4 Researches

Quiles JL, Farquharson AJ, Ramírez-Tortosa MC, Grant I, Milne L, et al. Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells. Biofactors. 2003;18:265.

We explored the effects of coenzyme Q10 on prostate cancer by investigating its impact on two cell lines: PNT2, which is non-cancerous, and PC3, which is cancerous. Our focus was on how this supplement influenced the levels of a specific protein called PHGPx and the production of reactive oxygen species (ROS), which are often linked to cancer progression.

We observed that the cancerous PC3 cells reacted quite differently to coenzyme Q10 compared to the non-cancerous PNT2 cells. There were no noticeable changes in the levels of PHGPx in the PC3 cells, yet we recorded a significant increase in ROS production. Additionally, coenzyme Q10 supplementation was found to reduce the growth of the cancerous PC3 line but did not impact the growth of the non-malignant PNT2 cells.

These findings suggest that coenzyme Q10 might offer a novel approach in cancer therapy, specifically for prostate cancer. However, further investigations are necessary to confirm these results before considering any clinical applications.

7.8

Increased energy focus

Most Useful Review

Doctor’s Best High Absorption CoQ10 with BioPerine is superb! I've noted increased energy, improved focus, and reduced mental fog. It enhances my overall wellbeing and supports my body. CoQ10 is an antioxidant that defends against free radical damage while BioPerine may help combat the growth of cancer cells and aids nutrient absorption.

Breast Cancer details

Yang HL, Lin PY, Vadivalagan C, Lin YA, Lin KY, et al. Coenzyme Q defeats NLRP3-mediated inflammation, EMT/metastasis, and Warburg effects by inhibiting HIF-1α expression in human triple-negative breast cancer cells. Arch Toxicol. 2023;97:1047. doi:10.1007/s00204-023-03456-w

Based on 8 Researches

CoQ combats TNBC progression

We explored the effects of coenzyme Q (CoQ) on triple-negative breast cancer (TNBC) cells, specifically its ability to counteract inflammation, metastasis, and atypical metabolism associated with the disease. The study looked closely at how CoQ interferes with the activity of HIF-1α, a protein that plays a significant role in cancer progression.

Our findings showed that CoQ effectively inhibited the NLRP3 inflammasome, which is involved in inflammatory responses, as well as reduced harmful markers associated with cancer stem cells. We also observed that CoQ promotes a switch from a more aggressive, invasive cellular behavior to a less aggressive form by enhancing the expression of E-cadherin, an important marker for cell adhesion, while lowering N-cadherin, which is linked to aggression in cancer cells.

Furthermore, we noted that CoQ disrupts the Warburg effect—where cancer cells adapt their metabolism to thrive under low oxygen conditions. It inhibited key glycolytic pathways, leading to decreased glucose uptake and reduced lactate accumulation, while enhancing mitochondrial function. This shift toward better energy production could significantly impact the treatment of TNBC.

Overall, our research highlighted how CoQ's ability to suppress HIF-1α expressions contributes to its potential in managing a variety of aggressive traits in TNBC, making it a promising area for further investigation and possible therapeutic application.

6.3

Raises morale

Most Useful Review

I was advised to take this by Dr Mohamed Al-Fayed while dealing with my breast cancer diagnosis. It has significantly raised my morale during a difficult time of tumour removal. I believe it's a powerful antioxidant, and I've been encouraged after speaking with medical professionals about its benefits.

Dizziness details

CoQ10's uncertain effects on dizziness

Kumar A, Kaur H, Devi P, Mohan V. Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Pharmacol Ther. 2009;124:259. doi:10.1016/j.pharmthera.2009.07.003

We explored the potential benefits of coenzyme Q10 (CoQ10) in addressing dizziness associated with Meniere-like syndrome. CoQ10 is known to play a crucial role in energy production within cells, particularly those in the heart, and it has been observed to have various health benefits.

In our review of the available research, we noted that CoQ10 may help improve immune function, which can indirectly assist individuals experiencing symptoms like vertigo or dizziness. While there is recognition of CoQ10's positive effects on heart health, the specific impact on dizziness remains somewhat uncertain.

We found that although trials suggested improvements in various cardiovascular conditions, the isolated effectiveness of CoQ10 for treating dizziness specifically wasn't definitively established in the studies reviewed. Thus, we remain cautiously optimistic about its potential while emphasizing the need for further research.

9.5

Dizziness relief

Most Useful Review

I greatly appreciate this CoQ10 supplement! After experiencing cardiovascular issues, I started taking one capsule daily with food, and the dizziness I had been experiencing gradually disappeared. It has also reduced my hair loss, which has been a lovely surprise. I genuinely love this product!

Whooping Cough details

Very good for my mother’s heart health. She suffers from high blood pressure and severe seizures. The prescribed tablets caused her a dry cough, so on a local doctor’s advice, she switched to coenzyme Q10. She noticed positive results, with attacks stopping and increased energy. This Q10 is far more effective than what she had been taking, and she never goes without it.

Pelvic Pain details

I began taking CoQ10 to alleviate the muscle pain linked to statin medications. This product has completely eliminated the soreness in my muscles when I take one capsule twice daily with meals.

Sleep Apnea details

Mermigkis C, Bouloukaki I, Mastorodemos V, Plaitakis A, Alogdianakis V, et al. Medical treatment with thiamine, coenzyme Q, vitamins E and C, and carnitine improved obstructive sleep apnea in an adult case of Leigh disease. Sleep Breath. 2013;17:1129. doi:10.1007/s11325-013-0816-5

Likely Very Effective

Coenzyme Q10 in sleep apnea study

We explored the impact of various treatments, including coenzyme Q10, on obstructive sleep apnea (OSA) in a patient with adult-onset Leigh disease. This condition often presents with severe neurological symptoms, complicating the patients’ overall health and quality of life.

An overnight sleep study revealed the presence of OSA, which had developed shortly before the neurological symptoms became apparent. Treatment included high doses of thiamine, coenzyme Q, L-carnitine, and vitamins C and E, along with effective management of OSA through continuous positive airway pressure (CPAP).

Following this combined approach, we observed a marked clinical improvement not only in the patient's sleep quality but also in their neurological outcomes. While coenzyme Q10 was part of this combination therapy, its specific contribution to alleviating sleep apnea symptoms cannot be isolated from the other treatments. Overall, the findings suggest that recognizing and treating sleep apnea promptly can enhance patients’ well-being and potentially improve neurological conditions associated with Leigh disease.

8.3

Better sleep achieved

Most Useful Review

I've been taking it at night, and it has noticeably improved my sleep. My weekly migraines are also gone, which contributes positively to my sleep apnea condition.

Adenoiditis details

The best of the best! I have sinus arrhythmia and often experienced heartbeats echoing in my ears and throat, making it difficult to breathe. The cardiologist prescribed Bisoprolol, but I felt I needed something more. I began to explore other options to support my heart and discovered this product. I have been taking it continuously for six months now, and I've stopped taking Bisoprolol 3-4 months ago, despite it being prescribed for life. Remarkably, I no longer experience bothersome symptoms, although there is still a slight arrhythmia. This has been a miracle for me!

Bloating details

This product has significantly improved my digestion and intestinal health. I noticed a difference; while I went to the bathroom more frequently, I also experienced relief from bloating and gas. I've read it supports brain health and combats lethargy. The taste is acceptable, and they come in vegetable capsules, which are good for heart health too.

Rash details

The composition is clean, and the capsules are conveniently sized and easy to swallow. I have been taking them for only two weeks to address insulin resistance. I feel more energetic, snack less, and have fewer cravings for sweets. The rashes on my face have decreased, and I calm down more quickly after stress. The results are evident, and I hope to enhance my metabolism through this supplement. Thank you for the fast delivery and excellent quality.

Acne details

Supplement may ease isotretinoin side effects

Fabbrocini G, Cameli N, Lorenzi S, De Padova MP, Marasca C, et al. A dietary supplement to reduce side effects of oral isotretinoin therapy in acne patients. G Ital Dermatol Venereol. 2014;149:441.

We undertook a study to see if a dietary supplement containing gamma linolenic acid, vitamin E, vitamin C, beta-carotene, coenzyme Q10, and Vitis Vitifera could help reduce common side effects linked to oral isotretinoin treatment for acne. This treatment is well-known for causing dry skin, redness, and peeling—issues that can make patients less willing to stick with their medication.

To explore this, we worked with 48 patients suffering from nodular acne, splitting them into two groups. One group received isotretinoin alongside the dietary supplement, while the other group only took isotretinoin for a duration of six months. We carefully measured various factors, including acne severity, hydration levels, and skin conditions such as erythema and dryness. We also inquired about how often patients adhered to their prescribed treatment.

Our findings revealed that those who used the dietary supplement experienced fewer side effects compared to those who just took isotretinoin. Specifically, they reported less erythema and dryness, as well as feeling more hydrated overall. Additionally, we noted an increase in treatment adherence in the group that took the supplement. Thanks to its antioxidant and moisturizing properties, this dietary supplement could indeed be a helpful addition for anyone undergoing isotretinoin therapy, making the journey a bit easier for patients.

9.5

Reduced acne

Most Useful Review

I found L-cysteine and vitamins effective together, as my skin has lightened, and my acne has greatly reduced!

Headache details

Coenzyme Q10 shows effectiveness against migraines

Yaghini O, Hoseini N, Ghazavi MR, Mansouri V, Nasiri J, et al. A Comparative Study on the Efficacy of Coenzyme Q10 and Amitriptyline in the Prophylactic Treatment of Migraine Headaches in Children: A Randomized Controlled Trial. Adv Biomed Res. 2022;11:43. doi:10.4103/abr.abr_235_20

We investigated the effectiveness of coenzyme Q10 in treating migraines in children, comparing it with the commonly prescribed medication, amitriptyline. Our study involved 72 children, aged 5 to 15, who met the criteria for migraine diagnosis set by the International Headache Society.

Over a three-month period, we observed that coenzyme Q10 had positive therapeutic effects, particularly for those requiring long-term treatment. While amitriptyline provided quicker results, the differences between the two treatments in effectiveness were not significantly noticeable after three months. Both treatments led to improvements in the quality of life for the children involved.

Importantly, we noted that children taking amitriptyline experienced more side effects compared to those receiving coenzyme Q10. This finding positions coenzyme Q10 as a promising option due to its comparable effectiveness and better tolerated adverse effect profile.

9.5

Eliminated headaches

Most Useful Review

I’ve been taking CoQ10 for several years and it has completely resolved my constant headaches. I recommended it to my wife and two others, all of whom have also experienced relief. This product truly works!

Insomnia details

When I was young, I thought CoQ10 was overrated. However, now that I’m older, I’ve realised it helps with insomnia, allowing for deeper sleep. I recommend it for those over 30.

Constipation details

Suzuki S, Gotoda T, Kusano C, Ikehara H, Miyakoshi Y, et al. Effect of Ubiquinol Intake on Defecation Frequency and Stool Form: A Prospective, Double-Blinded, Randomized Control Study. J Med Food. 2019;22:81. doi:10.1089/jmf.2018.4233

Ubiquinol shows mixed effects

We conducted a study to examine how coenzyme Q10, in its reduced form known as ubiquinol, might affect constipation in individuals dealing with daily abdominal discomfort. Using a robust, double-blind, randomized control design, we enlisted forty-one patients who experienced either constipation or diarrhea. Participants were split evenly into two groups, with one receiving 150 mg of ubiquinol each day for twelve weeks, while the other group received a placebo.

Over the course of the study, we had participants keep a daily diary to monitor their defecation frequency and the consistency of their stools, following the Bristol Stool Form Scale. After twelve weeks, we noticed some interesting changes. The ubiquinol group reported a slight decrease in defecation frequency, averaging -0.1 times a day, while the placebo group saw an increase of +0.3 times a day. However, there was no significant change in stool form for the ubiquinol group, while the placebo group’s scores improved.

On the brighter side, we also found that the ubiquinol group experienced a notable improvement in their overall health perception, reflected in their quality of life scores. In contrast, there were no significant changes in the placebo group’s scores. Overall, our findings suggest that ubiquinol may modify bowel habits and enhance the quality of life for patients suffering from abdominal distress, despite the small drop in defecation frequency among those taking it.

9.5

Restores microbiome

Most Useful Review

These probiotics are of excellent quality. They significantly help with constipation and are essential for gut health. The compact packaging contains powdered probiotics that noticeably improve digestion after just a week of use.

Reflux details