Life Extension BioActive Complete B Complex

Mswelo VE, David MM, Banturaki A, Munyambalu DK, Hassan HA, et al. Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report. J Med Case Rep. 2025;19:60. doi:10.1186/s13256-025-05095-4

Pernicious anemia case in Uganda

We focused on a case of pernicious anemia in a 51-year-old Ugandan man who presented with recurring lower limb weakness. After initial treatment for vitamin B12 deficiency years ago and further testing, we confirmed his diagnosis of pernicious anemia marked by low cobalamin levels. Thanks to timely parenteral methylcobalamin therapy, he showed improvement. This case underscores the importance of recognizing vitamin B12 deficiency, especially in rural and resource-limited settings, to address neurological symptoms quickly.

9.5

Visible improvements

Most Useful Review

An excellent form of B vitamins. I noticed a much calmer and cheerier mood in my teenager, along with increased strength and endurance. I'm very pleased with the effects of this vitamin. We will undoubtedly order more from this company! The results are evident, as blood tests for my child with a B12 deficiency returned to normal. This form of the drug truly works and is well absorbed!

Leg Cramps details

Vitamin B complex effective for cramps

Based on 2 Researches

Chan P, Huang TY, Chen YJ, Huang WP, Liu YC. Randomized, double-blind, placebo-controlled study of the safety and efficacy of vitamin B complex in the treatment of nocturnal leg cramps in elderly patients with hypertension. J Clin Pharmacol. 1998;38:1151.

We conducted a randomized, double-blind study to see if vitamin B complex could help older adults with nighttime leg cramps. Over three months, participants reported their cramp frequency and intensity.

The results were encouraging—86% of those taking vitamin B complex saw significant improvement, while the placebo group showed no notable changes. This suggests that vitamin B complex is a promising and safe alternative to traditional treatments like quinine, which can have unpleasant side effects.

9.5

Recommended for legs

Most Useful Review

Excellent! I found this drug effective for my leg discomfort. On my doctor's advice, I started taking this complex, and I recommend it for those with similar issues.

Polycystic Ovary Syndrome details

My hair and nails began to grow much faster and noticeably improved 😊 A good form of absorption, large dosages do not cause allergies, and all the excess is excreted in the urine. This is great for girls with polycystic ovary syndrome, which I take on my doctor's recommendation. I use this drug in courses, and the quality is always excellent 🙂 If my review was helpful, please like it 👍

Chronic Fatigue Syndrome details

B12 and folic acid show variability

Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. doi:10.1371/journal.pone.0124648

We examined the effects of vitamin B12 injections, combined with folic acid, on 38 patients with myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome.

Participants were split into "Good" and "Mild" responders based on their improvement. Good responders reported greater progress with more frequent injections and higher doses of both supplements.

However, for Mild responders, the improvement was limited, suggesting that while there is potential for benefit, the response can vary widely among individuals. Overall, further investigation is needed to explore optimal treatment strategies.

9.5

Increased concentration

Most Useful Review

On the first day, I felt a burst of energy! I had better concentration and less fatigue, which also improved my mood. I definitely recommend taking it twice a year.

We explored the case of a 23-month-old boy diagnosed with Imerslund-Gräsbeck syndrome (IGS), a rare disorder causing severe anemia. This child showed significant blood cell reduction and poor growth, which led to investigations identifying two genetic variants linked to his condition.

Remarkably, vitamin B12 replacement therapy resulted in a strong recovery. This case highlights how vital it is to diagnose IGS early in cases of severe anemia, ensuring timely treatment to avoid long-term complications, including potential neurological damage.

9.5

No side effects

Most Useful Review

I ordered this complex for myself and my parents due to iron deficiency anaemia. The doctor recommended B-group vitamins due to high homocysteine levels, which pose risks for cardiovascular health. Many pharmaceutical options include harmful additives, but this bioactive complex has everything required. I feel fantastic and noticed no side effects, while the price-to-quality ratio is excellent. To aid absorption, it’s also important to take magnesium and vitamin C.

Anxiety details

Niacin helps alleviate anxiety symptoms

Based on 7 Researches

Samad N, Hameed A, Manzoor N, Shoukat S, Irfan A, et al. Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment. Exp Gerontol. 2024;198:112624. doi:10.1016/j.exger.2024.112624

We examined the impact of Niacin on anxiety and memory loss caused by aging in a rat study. Rats were grouped and treated with various doses of Niacin and D-galactose for 14 days, followed by behavioral tests to assess anxiety and memory.

Our results showed that Niacin significantly reduced anxiety-like symptoms and improved memory deficits. Additionally, it mitigated factors like oxidative stress and inflammation, enhancing brain health. Overall, Niacin's antioxidant and neuro-modulatory properties suggest it may be beneficial in addressing aging-related psychiatric issues.

8.8

Positive anxiety relief

Most Useful Review

For a long time, I researched various vitamin B complex brands before choosing this one, and I have no regrets. These vitamins positively affect the nervous system, improving sleep, reducing anxiety, and helping to combat stress. They work best in combination as they enhance each other's effects. The dosages are high for quick replenishment, and the bright yellow urine is a normal bodily reaction. My whole family takes them, and we are very satisfied with the results. I highly recommend them.

Bone Pain details

Carnitine aids bone pain relief

Tabei SM, Mazloom M, Shahriari M, Zareifar S, Azimi A, et al. Determining and surveying the role of carnitine and folic acid to decrease fatigue in β-thalassemia minor subjects. Pediatr Hematol Oncol. 2013;30:742. doi:10.3109/08880018.2013.771388

We examined the potential benefits of carnitine and folic acid in reducing bone pain and fatigue in patients with beta-thalassemia minor. Over three months, 73 participants received either carnitine alone, a combination of carnitine and folic acid, or folic acid alone, while a control group went without supplementation.

Our results showed that carnitine significantly improved plasma levels and reduced bone pain and muscle weakness for those affected by this condition. Although folic acid improved red blood cell levels, its impact on bone pain was not directly highlighted. Overall, our findings suggest that carnitine can be beneficial in addressing bone pain in these patients.

9.5

Pain syndrome relief

Most Useful Review

Excellent vitamins! I’ve ordered six cans already. The vitamins are in the correct form. I have serious spine issues, including protrusions and herniation. After years of taking other vitamins with no effect, this complex made my pain syndrome disappear entirely, and I no longer face seasonal flare-ups.

Chest Pain details

Vitamin B complex's minor impact on health

Martí-Carvajal AJ, Solà I, Lathyris D, Dayer M. Homocysteine-lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2017;8:CD006612. doi:10.1002/14651858.CD006612.pub5

We evaluated the effects of vitamin B complex supplements on chest pain and heart health by reviewing 15 studies involving over 71,000 participants.

Our investigation revealed that while there were no significant differences in rates of heart attacks, overall deaths, or serious side effects between those receiving vitamin B complex and placebo, there was a slight reduction in stroke incidence.

However, the benefits were minimal and outcomes varied with dosages, indicating that more research is needed to draw firm conclusions about the effectiveness of these vitamin interventions on cardiovascular events.

9.5

Increased energy

Most Useful Review

After months of health issues, I discovered extremely low B vitamins. Within just two doses, my energy improved drastically, allowing me to get out of bed. Symptoms of peripheral neuropathy vanished within a week, and my stomach acid production began to normalise. If you experience reactions from niacin, start with lower doses. Initially, I had redness and itching on my chest, but those symptoms have considerably reduced.

Chondromalacia Patella details

I previously suffered from Chondromalacia Patella and would be bedridden for weeks. However, after taking 2 capsules of vitamin B in the morning and 2 capsules of magnesium in the evening, I feel much better within a couple of days. I also incorporate gymnastics and utilise Kuznetsov's applicator. This combination alters the colour of my urine to a bright canary hue and causes my face to turn pink for about 15 minutes after ingestion, but it fades quickly. Additionally, I experience a boost in energy levels. I wholeheartedly recommend it! 💯

Cold Sores details

Improved cold symptoms

There appears to be an error in the component display regarding the amount of folic acid, which is stated as 400mcg instead of the correct 680mcg. I take one capsule daily in conjunction with multivitamins. After starting this regimen, I noticed I'm no longer experiencing drowsiness post-meal, and my body feels warm with enhanced sensitivity to the cold. Surely, this must be due to an improvement in metabolism? It's a rather unexpected but delightful effect.

Low Libido details

After about a week, I noticed a certain lightness in my head. Waking up at 7 is now much easier, even with breastfeeding 3-4 times a night. My libido is starting to return, which I feared might not happen after childbirth and Covid. I definitely recommend this product.

Mild Cognitive Impairment details

Compensates vitamin loss

I buy this for my mother, who is diagnosed with dementia, and it effectively compensates for her B vitamin deficiency.

Sleep Apnea details

This vitamin complex is superbly selected! B vitamins positively impact all body systems, counteracting modern deficiencies. They enhance sleep quality, reduce anxiety, alleviate tension, and help with muscle weakness. B vitamins should only be taken in combination as they better absorb alongside one another.

Brain Tumor details

Pyridoxine promotes glioblastoma cell death

Based on 2 Researches

Martínez-Mendiola CA, Estrada JA, Zapi-Colín LÁ, Contreras-Chávez GG, Contreras I. Effect of pyridoxine or cobalamin supplementation on apoptosis and cell cycle progression in a human glioblastoma cell line. Int J Neurosci. 2024;134:1320. doi:10.1080/00207454.2023.2263815

We explored the effect of vitamin B6 (pyridoxine) and B12 (cobalamin) on human glioblastoma cells, known for their aggressive nature. By treating cell cultures with varying doses of these vitamins over 24-72 hours, we aimed to see how they influenced cell survival and progression through their life cycle.

Our findings revealed that pyridoxine significantly reduced cell viability, likely due to inducing apoptosis, while cobalamin demonstrated some protective qualities against this effect. Although cobalamin did not boost apoptosis directly, it did intervene in the negative impact of pyridoxine on cell viability.

9.5

Relief and improvement

Most Useful Review

I follow the keto diet and have a fibroid tumour in my uterus. The doctor prescribed this product, and I found it to be wonderful. I experienced significant relief, and my health and mental state improved. The tumour is small, and I highly recommend it. The quality is excellent, the ingredients are good, and the quantity is sufficient. There is no noticeable taste, and the packaging is nice.

Cardiovascular Disease details

Wang XQ, Yin S, Wang QW, Bai WW, Tan RH, et al. Vitamin B6 allosterically activates AMPK to promote postischemic angiogenesis in mice. Eur J Pharmacol. 2025;993:177413. doi:10.1016/j.ejphar.2025.177413

Vitamin B6 aids heart recovery

We investigated how vitamin B6 supports heart recovery after heart attacks by promoting new blood vessel growth, known as angiogenesis. In laboratory tests, vitamin B6 improved cell migration and tubule formation, vital for forming new blood vessels.

Remarkably, long-term vitamin B6 supplementation showed significant improvements in heart function and reduced inflammation in mice following heart attacks. This suggests that vitamin B6 could be a beneficial aid for heart recovery, harnessing a specific pathway involving a protein called AMPK.

9.5

Calmed emotional state

Most Useful Review

B vitamins enhance cerebral circulation, normalise cardiovascular functions, and support the immune system. After taking it consistently, I feel calmer and less reactive to stimuli. Symptoms like dizziness and palpitations have disappeared, and my digestion has improved. I will continue to take this beneficial complex.

Celiac details

Celiac-safe supplement

This B-complex is a valuable addition to my supplements, as it can be challenging to obtain sufficient B vitamins from my diet. It's reassuring that it's safe for those with celiac disease and dairy allergies. I recommend this product, taking it every other day with food, although the tablets are large, they are manageable to swallow.

Frozen Shoulder details

I take one tablet a day, mainly after breakfast. I used to have frequent mouth ulcers and swollen gums, but since I started this, they've significantly improved. I also experienced headaches and severe stiff shoulders, but now they're gone. This increase in sweating seems to indicate an improved metabolism, which is pleasing. Though the capsules' size and smell did not bother me, I’ve yet to experience a niacin flush. Overall, my physical condition feels resolved, and I definitely want to continue!

Osteoporosis details

Great, I have quite severe osteoporosis and have been taking B Complex for many years. This is, in my opinion, the best product available on the market.

Pelvic Pain details

Gokhale LB. Curative treatment of primary (spasmodic) dysmenorrhoea. Indian J Med Res. 1996;103:227.

Based on 4 Researches

Vitamin B1 shows promising results

We assessed how effective oral vitamin B1 could be in treating primary dysmenorrhea, which causes significant pelvic pain in young women. In a robust study involving 556 participants aged 12-21 years, we administered 100 mg of vitamin B1 daily for 90 days.

The results were promising, with 87% of participants reportedly completely cured, while 8% experienced some relief. Notably, these positive outcomes persisted for two months after treatment ended, showcasing vitamin B1 as a safe and cost-effective approach to address the root cause of pelvic pain.

8.8

Pain relief noted

Most Useful Review

Reception of the complex began with a typical mistake: I failed to eat properly. After 20 minutes, I experienced a reaction to niacin: cramping stomach pain, flushing of the face, and redness of the skin on my face, neck, and hands. Fortunately, I am familiar with niacin's effects and did not panic. After drinking two glasses of water, the reaction subsided in 20 minutes. I was impressed by the drug's therapeutic effect. From the first day of taking it, I felt a surge of strength, and the spinal pain decreased. I have been taking it for two weeks now; my lips no longer feel dry, symptoms of post-COVID syndrome have diminished, my training is easier, and my sleep has improved.

Pneumonia details

I recommend starting B vitamins right after treating pneumonia caused by Covid, alongside magnesium from the same brand. After three weeks of use, the results are positive - I've felt stronger and have energy for physical activities and work. I take 2 capsules a day, and they absorb well.

Shingles details

Classic item that I would be in trouble without. I have taken it many times; it’s a large capsule, but very effective. Before taking it, I often suffered from mouth ulcers when tired. Since I started, I’ve been feeling better. It’s an essential supplement for me, and I intend to continue usage. It helped me heal quickly when I had Shingles or caught a cold.

Back Pain details

Vitamin B12 effectively reduces pain

Based on 14 Researches

Mauro GL, Martorana U, Cataldo P, Brancato G, Letizia G. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci. 2000;4:53.

We sought to understand how intramuscular vitamin B12 could help alleviate low back pain in patients with mechanical lumbago. In a rigorous study involving 60 participants, we compared the effects of vitamin B12 to a placebo.

Our findings indicated that those receiving the vitamin reported significantly less pain and disability, as measured by a visual scale and disability questionnaire. Notably, those on vitamin B12 also used less paracetamol than the placebo group.

Overall, our study confirmed that vitamin B12 can be effective for treating low back pain without nutritional deficiency.

9.5

Healed mouth corners

Most Useful Review

My daughter complained of pain from cracked corners of her mouth. After giving her C and B vitamins, she reported no pain and her healing was swift. This product is a staple in our family for overall health.

Rheumatoid Arthritis details

Effective pain relief

I took it for about six months to prevent Rheumatoid arthritis and arthritis, and it was effective. I'm much better now that I don't have to take it daily. However, I was informed that excessive B6 could cause pain, which it certainly did. I wish to continue taking it periodically and drinking it in the future.

Tinnitus details

Improved concentration

This review is important for anyone who has tinnitus. I've suffered from tinnitus for 8 years, experiencing high-level ringing in my ears. After an MRI and MRA showed no issues, I researched treatments and discovered the benefits of the B vitamin family. Methyl B12 has significantly improved my concentration in school, reduced my nervousness, enhanced my sexual function, and noticeably reduced my tinnitus throughout the day. I'm delighted to share this review with you.

Adenoiditis details

No more serious illness

After a week on this complex, I've gained strength and energy, avoiding the lethargy I typically experience. While my family fell ill, I managed to avoid fever and joint pain, with my runny nose clearing after only three days—much shorter than my usual two-week struggle. I'm thrilled, especially taking it with vitamin C for absorption.

Chemotherapy details

This is amazing. I bought it for my friend who is losing hair from Chemotherapy. Her doctor recommended she take vitamin B, and the effects were evident. After taking it, her hair loss has significantly reduced, and she also has more energy during the day. A good product!

Heart Disease details

VB6 helps heart recovery post-AMI

We explored how vitamin B6 (VB6) supports heart recovery post-heart attack. In our study, we found that VB6 encourages angiogenesis, which is crucial for healing. Through experiments, we noticed that VB6 helps in cell migration and blood vessel formation by activating a specific protein that plays a key role in these processes. Additionally, long-term use of VB6 improved heart function in mice. While these findings are promising, it’s important to note that further research is necessary to fully understand VB6's effects in humans.

9.5

Reduces stress levels

Most Useful Review

This vitamin complex has been amazing! After two years of use, I’ve seen improvements in my gut function and skin health, and I’ve become more emotionally stable. It aids in coping with stress, supports the immune system, and enhances overall bodily functions including the cardiovascular system. This B vitamin complex effectively does its job without adverse reactions.

Hypothyroidism details

Thiamine enhances memory in hypothyroidism

Based on 4 Researches

Saberi R, Mirazi N, Amirahmadi S, Darbandi ZK, Vafaee F, et al. Ameliorative effects of thiamin on learning behavior and memory dysfunction in a rat model of hypothyroidism: implication of oxidative stress and acetylcholinesterase. Metab Brain Dis. 2023;38:2603. doi:10.1007/s11011-023-01317-0

We explored the impact of thiamine (Vitamin B1) on memory and learning in rats with hypothyroidism. In a study involving 50 young rats, we treated them with a hypothyroid-inducing agent and varying doses of thiamine over seven weeks.

The results were promising—thiamine improved memory in rats as evidenced by better performance in timed tests. Specifically, higher doses of thiamine led to increased memory retention and reduced oxidative stress. This suggests that thiamine could be a beneficial supplement for addressing memory issues related to hypothyroidism.

9.5

Increased energy

Most Useful Review

After taking this, I felt energetic for the first time in ages, reminiscent of my youth. Suffering from hypothyroidism, this supplement reminded me of what it’s like to have energy. My advice is to take only a third of the pill, as it contains a high amount of vitamin B6, which can lead to toxicity in large doses. I take it twice a week.

Athlete’s Foot details

Bought this product for my family's severe athlete’s foot and the effect has been impressive! The doctor recommended B miscellaneous food, so I purchased it. After using it for some time, the condition improved significantly, and I only need to continue with the B miscellaneous now.

Depression details

Vitamin B may alleviate depression symptoms

Based on 12 Researches

Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. doi:10.12182/20250160608

Our investigation looked into how Vitamin B affects behavior and neurotransmitter levels in rats undergoing stress-induced depression.

We set up three groups: a control group, a stressed group, and a stressed group receiving Vitamin B.

The results showed that Vitamin B improved neurotransmitter levels and reduced anxiety and depression-like behaviors in the rats. This suggests that Vitamin B could be beneficial in improving symptoms of depression driven by stress.

9.5

Significant health improvement

Most Useful Review

After a month of using this vitamin, I noticed a considerable improvement in my overall health. It specifically aided me in overcoming depression, which I had struggled with for a long time. If you seek a supplement that benefits not just your physical health but your overall well-being, I highly recommend this one.

Diabetes details

Myo-inositol aids diabetes management

Based on 11 Researches

Long L, Huang Q, Song T, Dai Z. Myo-inositol rescued insulin resistance and dyslipidemia in db/db mice. J Appl Biomed. 2024;22:74. doi:10.32725/jab.2024.009

We explored how Myo-inositol (MI) might help manage diabetes by studying its effects in db/db mice, a common model for type 2 diabetes. Findings showed that MI reduced high blood sugar and insulin levels, and it even improved insulin resistance, much like metformin does.

Additionally, MI lowered high triglyceride and cholesterol levels, which can benefit overall heart health. Interestingly, while it reduced fat cell formation, it didn't help control obesity in these mice. Overall, MI shows promise as a supportive treatment for hyperglycemia and related issues in diabetes patients.

8.8

Nervous system enhancement

Most Useful Review

I found this product remarkable; it hasn't improved the pie at all ❤. It's one of the highest quality types. My father's condition, affected by diabetes, has worn him out; however, this has proved wonderful for his nervous system, and if he continues taking it, I believe his condition will significantly improve.

Heart Attack details

Based on 7 Researches

Vitamin B6 aids heart recovery

We explored whether vitamin B6 can aid heart recovery after a heart attack. Our study showed that vitamin B6 promotes angiogenesis, the formation of new blood vessels, which plays a key role in heart function recovery.

We observed that vitamin B6 enhances cell migration and tube formation in laboratory settings, as well as improves heart function in mice after a heart attack. While it shows promise, we must remember that these results are based on animal studies, and more research is needed before drawing conclusions for humans.

8.3

Heart pain improvement

Most Useful Review

I found a good complex of coenzyme forms of B vitamins. I took it due to pain in my heart area, and it helped significantly.

High Cholesterol details

Niacin reduces cholesterol and oxidative stress

Based on 10 Researches

Hamoud S, Kaplan M, Meilin E, Hassan A, Torgovicky R, et al. Niacin administration significantly reduces oxidative stress in patients with hypercholesterolemia and low levels of high-density lipoprotein cholesterol. Am J Med Sci. 2013;345:195. doi:10.1097/MAJ.0b013e3182548c28

We examined how niacin (vitamin B3) impacts cholesterol levels and oxidative stress in patients with low HDL cholesterol. In this study, 17 participants with high cholesterol received niacin treatment over 12 weeks, while 8 healthy individuals served as controls.

The results were promising. We discovered a significant boost in HDL cholesterol and a drop in triglycerides among the patients. More importantly, niacin also reduced markers of oxidative stress, suggesting its benefits extend beyond just cholesterol management. However, CRP levels remained unchanged.

8.8

Supports mood

Most Useful Review

The complete vitamin B complex is excellent for the nervous system and aids those experiencing numbness. It benefits the eyes, skin, and internal organs, raising good cholesterol while reducing bad cholesterol. It enhances immunity and energy levels. I took it to alleviate migraine attacks, and it worked wonders, also improving my skin and nails. The high-quality package lasts a month for daily doses.

Ulcer details

Benfotiamine improves ulcer healing

Based on 7 Researches

Shokati Sayyad M, Khanjani MH, Amirbeik M, Seyedabadi M, Talebpour Amiri F, et al. The protective effect of benfotiamine on gastric ulcers in male rats: an experimental study. J Mol Histol. 2024;55:863. doi:10.1007/s10735-024-10237-x

We investigated how benfotiamine might impact stomach ulcers in male rats. The study involved dividing 30 rats into groups receiving different treatments, including benfotiamine at varying doses, following the induction of ulcers using indomethacin.

Our results showed that benfotiamine notably decreased gastric damage and lowered inflammation markers. Specifically, doses of 100 and 200 mg/kg appeared to enhance antioxidant levels and reduce tissue damage.

However, while these findings are promising, more research is needed to fully understand the mechanisms at play and assess benfotiamine's potential for human treatment.

8.8

Quick healing noted

Most Useful Review

I bought this to treat my son's acne, as Vitamin B is known for helping with sebum secretion. His acne, which did not improve with the dermatologist's treatment, cleared up rapidly when combined with cartilage. I also use it occasionally for mouth ulcers, and it appears to assist in quick healing.

Hot Flashes details

This is a great complex. At 34, I've encountered hormonal issues, specifically hot flashes and an irregular menstrual cycle. After starting the vitamin B complex, the hot flashes subsided, and my cycle began to normalise. I have been taking it for two months now, each morning after meals.

Indigestion details

While it doesn’t seem to help with the feeling of indigestion itself, I feel it alleviates the mental stress associated with having indigestion.

Liver Disease details

Methylcobalamin protects against liver failure

Based on 4 Researches

Xu W, Wang Y, Cui S, Zheng Q, Lin Y, et al. Methylcobalamin protects against liver failure via engaging gasdermin E. Nat Commun. 2025;16:1233. doi:10.1038/s41467-024-54826-6

We investigated how methylcobalamin, a form of vitamin B12, affects liver failure, particularly in cases of cholestasis. Methylcobalamin showed promise as it directly binds to and inhibits Gasdermin E, a protein linked to liver cell death.

In mouse models, this vitamin significantly reduced liver inflammation and damage, lowering mortality rates. These findings suggest that methylcobalamin could be a potential treatment option for preventing severe liver failure and related health issues.

Normalises liver function

Most Useful Review

I drink with my husband 2 course, excellent composition, well absorbed, works great. It helps to normalise liver function and improves sleep. Affects the nervous system positively, reduces anxiety and relieves stress. I noticed it improves my overall well-being. Don't fear high dosages as these are water-soluble vitamins; the body only takes what it needs, and the excess is excreted.

Food Poisoning details

Previously, I was prone to prickly heat, especially when consuming hot or fried foods. After starting this vitamin B complex, I've noticed that I no longer suffer from prickly heat, making it particularly beneficial during warmer weather. Additionally, I now feel much more energetic and less fatigued than before.

Acne details

Panthenol mask improves skin barrier

Likely Very Effective

Zhang X, Tao H, Deng Y, He X, Zhang Z, et al. Efficacy and safety of a panthenol-enriched mask for individuals with distinct impaired skin barrier subtypes. J Cosmet Dermatol. 2024;23:2109. doi:10.1111/jocd.16231

We aimed to evaluate how a panthenol-enriched mask, specifically La Roche-Posay Mask Pro, performs in improving skin barriers for different types, such as dry sensitive, oily sensitive, and oily acne-prone skin.

Over 177 participants used the mask under guidance, and we measured factors like hydration, sebum content, and redness at multiple intervals.

The results showed significant improvements across all skin types, particularly for oily acne skin, which saw reductions in sebum and redness. Importantly, there were no adverse effects reported, indicating that this mask can be a trusty companion for those with various skin concerns.

8.8

Reduced pimple size

Most Useful Review

I recently bought this as my stomatitis and acne weren't healing well! I take it after meals without experiencing any niacin flush. By the third day of taking it, my pimples had shrunk considerably! I think I will continue taking it to see how it progresses.

Blood Clot details

Tu YR, Tu KH, Lee CC, Fan PC, Yen CL, et al. Supplementation with Folic Acid and Cardiovascular Outcomes in End-Stage Kidney Disease: A Multi-Institution Cohort Study. Nutrients. 2022;14. doi:10.3390/nu14194162

Based on 6 Researches

USERS' SCORE

Good

Based on 25 Reviews

Folic acid reduces clot events

We examined the effects of folic acid supplementation on blood clot events in patients with end-stage kidney disease (ESKD). Analyzing data from over 2,000 patients, we divided them into daily and weekly supplementation groups for a mean follow-up of 5.8 years.

Our findings indicated that patients receiving daily folic acid had a lower rate of arteriovenous access thrombosis compared to those on a weekly regimen. However, we found no significant differences between the groups concerning major cardiovascular events or overall mortality.

More research is needed to fully understand the potential of folate in preventing thrombosis in this population.

9.5

Supports wellbeing

Most Useful Review

This product effectively combats fatigue and stress. I've taken it for 2 years, and I find it enhances my mood, normalises sleep, and boosts efficiency. It supports the body under pressure, lowers cholesterol, and improves cardiovascular function. Highly recommend!

Constipation details

Quality and taste good

This supplement assists with constipation. The quality, ingredients, packaging, and taste are all commendable. It’s advisable for pregnant women to consult a doctor before use.

Headache details

Pediatric migraine treatment with riboflavin

Based on 15 Researches

Das R, Qubty W. Retrospective Observational Study on Riboflavin Prophylaxis in Child and Adolescent Migraine. Pediatr Neurol. 2021;114:5. doi:10.1016/j.pediatrneurol.2020.09.009

Our examination focused on the effectiveness of riboflavin, a form of Vitamin B2, in treating migraines in children and adolescents aged six to 18. We conducted a retrospective observational study involving 42 patients, where we measured the frequency, intensity, and duration of their headaches.

Remarkably, we found significant reductions in headache days per month, with intensity and duration also decreasing. Most importantly, riboflavin helped decrease the reliance on acute medication and fewer missed school days. We suggest this affordable treatment as a safe option for pediatric migraines.

9.5

Alleviates fatigue

Most Useful Review

I ordered these vitamins based on a friend's recommendation and was very satisfied. I appreciated the composition; after a month of taking them, constant drowsiness disappeared, I felt energised, and headaches ceased. I recommend them to everyone!

Common Cold details

Zinc reduces diarrhea, colds in infants

Likely Very Effective

McDonald CM, Manji KP, Kisenge R, Aboud S, Spiegelman D, et al. Daily Zinc but Not Multivitamin Supplementation Reduces Diarrhea and Upper Respiratory Infections in Tanzanian Infants: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr. 2015;145:2153. doi:10.3945/jn.115.212308

We investigated the impact of daily multivitamin and zinc supplementation on the health of Tanzanian infants. In our randomized, double-blind study involving 2,400 infants, we compared the effects of these supplements against a placebo over 18 months.

Our findings revealed that while zinc significantly reduced occurrences of diarrhea and acute respiratory infections, multivitamins did not provide additional benefits. Ultimately, zinc supplementation starting at 6 weeks may be beneficial for reducing some common illnesses in infants, but multivitamins did not show any significant positive impact.

9.5

Effective energy boost

Most Useful Review

This is the best cost-effective and most effective vitamin B supplement I've ever encountered. It combines ingredients that are uncommon in Japan, and it outperforms energy drinks sold in drugstores that are less than 500 yen. It makes me feel better, and when I take potassium the day after overindulging, I don't experience swelling at all, allowing me to wake up feeling normal.

Insomnia details

Ohta T, Ando K, Iwata T, Ozaki N, Kayukawa Y, et al. Treatment of persistent sleep-wake schedule disorders in adolescents with methylcobalamin (vitamin B12). Sleep. 1991;14:414.

Vitamin B12 aids sleep disorders

We observed two adolescents struggling with severe sleep-wake schedule disorders respond positively to high doses of vitamin B12, specifically methylcobalamin. The 15-year-old girl with delayed sleep phase syndrome and the 17-year-old boy with hypernychthemeral syndrome showed immediate improvements after receiving 3,000 micrograms per day.

Notably, there was no evidence of vitamin B12 deficiency in either case, as their levels remained in the normal range. The girl's sleep duration reduced from 10 hours to 7 hours, while the onset of her sleep moved from 2 a.m. to midnight. The boy's sleep-wake cycle also adjusted slightly, indicating potential benefits of methylcobalamin for these disorders.

9.5

Addresses exhaustion

Most Useful Review

My experience with other brands included high doses of B12, which alleviated forgetfulness and bodily strain. I chose this B complex for my exhaustion due to insomnia from overtime work, and I found it effective. Melatonin didn’t work for me, but this helped me fall asleep quickly. The packaging quality and taste are commendable.

Chronic Cough details

This B-complex contains all necessary B vitamins. I took it for treating chronic fatigue and found it effective in overcoming tired adrenal glands syndrome, stress, and emotional strain. It also seemed to bolster my immune system. I highly recommend this supplement to everyone!

Yeast Infection details

Stopped yeast symptoms

She started giving her 11-year-old son one tablet at a time, but it proved to be a very strong dosage for him. He began to complain of weakness and a yeast infection in his body. She decided to stop giving it to him, and everything is now working out well. The drug is effective, and she plans to take it herself, but it seems to be unavailable in Russia now.

Diarrhea details

Helps frequent diarrhoea

If you frequently suffer from diarrhoea, then I can affirm that vitamin B can certainly assist you.

Heartburn details

I drink the complex on my neurologist's advice. The B vitamins are well absorbed. The large capsules do not cause heartburn or nausea if taken post-meal. They make life easier!

Ear Infection details

The quality is superb and well packaged. The ingredients are pure and the portions generous. There is a niacin flushing reaction, making the ears red and hot, or causing warmth in the stomach, which is visibly powerful. It promotes metabolism, leaves me feeling relaxed after eating, and enhances the nervous system. The taste, however, is relatively strong.

Knee Pain details

Niacin intake eases knee osteoarthritis pain

Based on 2 Researches

Zheng Z, Luo H, Xue Q. Association between niacin intake and knee osteoarthritis pain and function: a longitudinal cohort study. Clin Rheumatol. 2024;43:753. doi:10.1007/s10067-023-06860-w

We investigated how niacin intake impacts pain and function in individuals with knee osteoarthritis (OA).

Using data from the Osteoarthritis Initiative, we analyzed niacin consumption alongside pain and functional scores.

Our findings reveal a significant association between higher niacin intake and reduced knee pain, suggesting that boosting niacin levels might improve the quality of life for OA patients.

Notably, specific groups, including middle-aged individuals and women, experienced even greater benefits.

7.5

Improved pain relief

Most Useful Review

I bought it for my son as prescribed by the doctor. He bruised his elbow, which caused pain radiating to his shoulder. After taking it myself, I found the pain improved significantly, but one must take care as it can lead to allergies.

Irritable Bowel Syndrome details

Improves irritability