Ginkgo
9.5
Enhanced circulation
Most Useful Review
I’ve been using ginkgo biloba extract and have consistently experienced its promised benefits. It normalises metabolic processes, lowers cholesterol, and improves blood circulation. Additionally, it enhances brain circulation and reduces the likelihood of clots. I also notice improvements in memory and mental clarity. The recommended dosage works well for me.
9.5
Improved circulation
Most Useful Review
Excellent! A really useful supplement; it enhances blood circulation in the brain, and I can see the results. Fantastic!
Magnesium
9.5
Enhances cognitive abilities
Most Useful Review
I took this magnesium due to emotional stress and sleep issues. After taking two capsules before bed, I noticed significant improvements in sleep quality and memory. It effectively penetrates the brain, enhancing cognitive abilities, especially following two consecutive pregnancies.
9.5
Life-changing effect
Most Useful Review
Highly recommended! At just 26, I've had sleep issues for years, often not sleeping until 3-4am. After starting DOCTOR’s magnesium pill, I felt relaxed and experienced improved sleep quality. I now sleep around 12-1am, which is a remarkable change! Despite the larger pill size, it wasn’t a concern for me. I’m grateful for including magnesium in my regimen.
Calcium
9
Calcium therapy improves glioblastoma treatment
Targeting GOLPH3L improves glioblastoma radiotherapy by regulating STING-NLRP3-mediated tumor immune microenvironment reprogramming.
Most Relevant Research
Our study investigated the role of calcium, specifically vitamin B5 calcium, as an inhibitor of GOLPH3L in treating glioblastoma, a challenging form of brain tumor. We found that this compound may have potential in improving the effectiveness of radiotherapy, especially in cases resistant to standard treatments.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
By targeting GOLPH3L, which plays a role in creating an immunosuppressive tumor environment, we were able to observe that the vitamin enhanced the antitumor immune response. This suggests that calcium treatment could help shift the balance from tumor-promoting factors to those that boost the body's natural defenses against cancer.
Notably, our research revealed that patients with glioblastoma who received vitamin B5 calcium alongside radiotherapy showed improved responses. However, it’s essential to mention that while the outcomes are promising, the specific efficacy of vitamin B5 calcium as a standalone treatment needs further exploration and validation in clinical settings.
In summary, we might be looking at an exciting new avenue where calcium treatment could help reshape the outcomes of glioblastoma therapy, particularly when equipped with the knowledge of how it interacts with tumor biology.
9.5
Supports brain health
Most Useful Review
I truly admire this manufacturer! Magnesium is very helpful for the brain and maintaining calm, particularly crucial in epilepsy. Zinc enhances skin condition, and calcium is vital, especially considering the quality of milk these days. The product quality is exceptional!
Zinc
9
Zinc aids in glioblastoma treatment
Ketogenic diet with oxyresveratrol and zinc inhibits glioblastoma and restores memory function and motor coordination.
Most Relevant Research
We evaluated the potential of zinc in combination with a ketogenic diet and oxyresveratrol in fighting glioblastoma, a highly aggressive brain tumor. Through a series of carefully designed experiments, we examined how these treatments affect tumor growth and overall brain function.
In our study, we induced brain tumors in Wistar rats and then applied our treatment regimen. We tracked various outcomes, including tumor size, proliferation rates, memory function, and motor coordination. By assessing glucose and ketone levels, we gained insights into the metabolic changes occurring as a result of the treatments.
The findings suggested that zinc played a supportive role alongside the ketogenic diet and oxyresveratrol in reducing tumor growth. Moreover, these treatments appeared to enhance memory and motor coordination, indicating a multi-faceted benefit. Overall, this progression offered valuable information about the role of diet and supplementary compounds in battling aggressive brain tumors like glioblastoma.
In our study, we induced brain tumors in Wistar rats and then applied our treatment regimen. We tracked various outcomes, including tumor size, proliferation rates, memory function, and motor coordination. By assessing glucose and ketone levels, we gained insights into the metabolic changes occurring as a result of the treatments.
The findings suggested that zinc played a supportive role alongside the ketogenic diet and oxyresveratrol in reducing tumor growth. Moreover, these treatments appeared to enhance memory and motor coordination, indicating a multi-faceted benefit. Overall, this progression offered valuable information about the role of diet and supplementary compounds in battling aggressive brain tumors like glioblastoma.
9.5
Essential for brain
Most Useful Review
This high-quality zinc supplement is fantastic; it increases immunity and is essential for brain function and physical activity.
N Acetyl L Cysteine
9.5
Improves memory significantly
Most Useful Review
Improves brain function. I took it for recovery after surgery. During long subway trips, my head began to spin, feeling as if I had "rested" it. I consumed the drug for a month, taking 2 capsules daily, morning and evening, and the symptoms ceased. Overall, my memory and performance have significantly improved.
8.8
Enhanced brain activity
Most Useful Review
I read an article about this product, which yields results in improving brain activity. While my general condition has improved, I have become more productive. The size of the capsules is ideal.
Selenium
9.5
Immunity boost
Most Useful Review
Selenium improves immunity and brain function. Initially purchased for immunity, I've learned it works best with Iodine. It’s crucial for preventing free radicals and maintaining cell health, which plays a vital role in brain function.
9.5
Health maintenance
Most Useful Review
Selenium is an indispensable supplement for cancer prevention. If you wish to maintain your health and reduce the risk of tumours, then this supplement is essential.
Alpha Gpc
9.5
Increased focus
Most Useful Review
Wonderful! Productivity has increased by 220%. This supplement for the brain is quite expensive but worthwhile. It has significantly aided me during my programming courses and while learning English. I notice enhanced attentiveness and perseverance, as well as a strong desire to absorb new information. My interests have broadened, and my thinking has improved. I took 2 tablets daily, which helped my sleep; I now fall asleep faster than before.
9
Enhanced motivation
Most Useful Review
In my experience, this is an excellent nootropic. I was astonished at how great I felt after taking just half the recommended dose. My brain fog cleared, fatigue vanished, and I felt vibrant and motivated. With each dose, I can concentrate intensely on any brain task. The NOW brand offers a good price compared to others, and I will continue to purchase it.
Vitamins
9.5
Tumour markers normal
Most Useful Review
I've been taking Vitamin A for five years. My cancer tumour markers were positive earlier, and my doctor advised vitamins A and D. I was taking 225,000 IU daily for about six months, which helped reduce chickenpox zoster virus infections, with no side effects. After fasting, walking on organic juices, and maintaining an organic diet, my tumour markers returned to normal over two years. Now, I take 75,000 IU daily. In Japan, most people are vitamin D deficient due to limited sun exposure.
9.5
Relief and improvement
Most Useful Review
I follow the keto diet and have a fibroid tumour in my uterus. The doctor prescribed this product, and I found it to be wonderful. I experienced significant relief, and my health and mental state improved. The tumour is small, and I highly recommend it. The quality is excellent, the ingredients are good, and the quantity is sufficient. There is no noticeable taste, and the packaging is nice.
Ubiquinol
9.5
Increases brain health
Most Useful Review
Excellent! Ubiquinol is the most absorbable form of CoQ10. It's pricier, but worth the investment! It significantly boosts blood levels of this essential substance, crucial for maintaining good brain and heart health as we age. I take 400 mg daily for improved results in sports and activities that require mental energy. This bottle of 120 softgels is excellent!
9.5
Boosts vitality
Most Useful Review
I purchased this supplement for my mother-in-law, who takes statins that deplete coenzyme Q10. This product, containing ubiquinol for better assimilation, provides a noticeable increase in energy and positively impacts brain function.
Alpha Lipoic Acid
9.5
Enhanced brain function
Most Useful Review
Perfectly! This product is ideal! My brain functions like clockwork, with heightened attention and concentration. I feel more invigorated, and my health has improved significantly, alongside numerous pleasant bonuses. It's truly a fantastic find for someone in today's world!
9.5
Maintained brain activity
Most Useful Review
I constantly order this for my mum, who is over 60. These supplements are excellent, helping to maintain her brain activity! She is delighted and has experienced no side effects.
Glycine
9.5
Increased rehabilitation chance
Most Useful Review
Many are aware that glycine is recommended for memory issues and irritability. It effectively reduces psycho-emotional stress and improves mental performance. It can lessen the severity of brain disorders due to ischemic strokes and traumatic brain injuries. Administering a large dose within a few hours post-stroke can significantly enhance rehabilitation prospects. It is advisable to keep glycine in your first aid kit.
9
Relieved brain injuries
Most Useful Review
Glycine is a helpful supplement for various neurological issues, including traumatic brain injuries and emotional stress, enhancing memory and thought clarity. It aids in reducing withdrawal symptoms and cravings for alcohol. You can buy glycine in pharmacies, but opting for pure 100% glycine powder is more beneficial.
Sulforaphane Glucosinolate
9.5
Tumour-free belief
Most Useful Review
I was diagnosed with bladder cancer in 2016. My doctor suggested broccoli as a superfood to help combat cancer. Although I dislike broccoli, BroccoMax contains the necessary sulforaphane. I've taken it daily since October 2017 and believe this quality product, along with lifestyle changes, has kept me tumour-free.
9.5
Stimulates detoxification
Most Useful Review
BroccoMax, containing sulforaphane, significantly enhances the body's detoxification system. It has numerous health mechanisms, including anti-inflammatory effects, promoting brain health, and supporting healthy cell replication. The coating of the capsule protects its contents from degradation, substantially improving bioavailability.
Melatonin
9.5
Restful sleep
Most Useful Review
Fast acting, these tablets help my brain relax for a good night’s sleep without the fog in the morning. Their high potency allows me to return to sleep if I wake during the night. I trust this brand for its quality and affordability, with no unpleasant chemicals and high-quality ingredients.
9.5
Quality sleep
Most Useful Review
Excellent product! Pleasant-tasting without any nasty aftertaste. Fast acting, they assist my brain in relaxing for a good night’s sleep, ensuring no morning brain fog. Their high potency helps me get back to sleep if I wake at night. I trust this brand for great quality at an affordable price, with no harmful chemicals and premium ingredients.
L Carnitine
9.5
Daily energy boost
Most Useful Review
Great quality! I take it daily as a brain and energy booster in the morning. I have no complaints so far.
9.5
Brain support boost
Most Useful Review
I've been using it since 2014. Carnitine is very helpful for both the brain and exercise, so I continue to take it. It truly is a high-quality product.
Inositol Hexaphosphate
8.8
Speedy delivery service
Most Useful Review
I ordered Jarrow Formulas IP6, and the immediate delivery impressed me. The capsules help chelate and remove the iron accumulation in my brain due to CCSVI, and I believe they are making a difference. I'm extremely happy with both the effectiveness and the swift service provided.
9.5
Cancer prevention benefits
Most Useful Review
Inositol hexaphosphate (IP6) is a carbohydrate that occurs naturally in many plant foods. I've understood its importance in cancer prevention and controlling tumour growth. IP6 acts as an antioxidant and has showcased remarkable benefits for human health, including immune system enhancement and reducing cholesterol levels. Some studies even indicate that it can enhance conventional chemotherapy's effects and improve quality of life for cancer patients.
Acetyl L Carnitine
9.5
Improves brain function
Most Useful Review
I absolutely love this Acetyl-L-carnitine! I've taken it multiple times and believe it helps improve brain function and fat metabolism significantly. I trust the Now brand for its quality. These capsules are convenient to take and do not affect sleep. During its use, I've felt more energetic and mentally sharp.
8.8
Boosts brain recovery
Most Useful Review
Now Foods Acetyl-L-carnitine has significant benefits for metabolic processes. Its neurotrophic effects inhibit cell death and aid in restoring nervous tissue structure. This substance can help manage brain function under critical conditions and improve cognitive performance. It proves effective in supporting brain health.
Turmeric
9.5
Memory improvement
Most Useful Review
To prevent brain ageing, I discovered this product containing only curcumin, which I began taking. Other supplements with turmeric extract are available, but curcumin alone is less effective. After around a week, I noticed a recovery in my memory, and my forgetfulness significantly decreased. I am no longer vague throughout the day, and my work efficiency has clearly improved. I appreciate the high quality. I take it daily; as it has no taste, I find it easy to consume after meals. Compared to other products, this soft gel capsule is much easier to swallow, and it doesn’t cause me any discomfort. I intend to continue using it for as long as possible.
8
Anti-tumor activity
Most Useful Review
Curcumin is indeed a remarkable compound, offering significant anti-inflammatory and anti-tumor properties due to its antioxidant qualities. Unlike turmeric, which contains only 2-3% curcumin, this potent remedy impacts various signalling pathways, enhances nutrient transport to tumour cells, and can even promote the destruction of unhealthy cells. It's beneficial not just for joint soreness but rejuvenates the body's cells overall. You truly should explore its effects online—it's astonishing! My experience suggests it contributes positively to longevity.
Iodine
9.5
Mental clarity enhanced
Most Useful Review
This product has significantly improved my mental clarity, effectively eliminating brain fog! I mix it with warm water and a teaspoon of salt daily, which has positively impacted my everyday life. Since starting this product, I also feel I have lost weight as it helps regulate cortisol levels. This product, along with Selenium, is essential for anyone with thyroid conditions. Highly recommended!
9.5
Memory clarity restored
Most Useful Review
I appreciated the effect on stabilising my brain activity. After suffering from memory issues post-COVID, this iodine helped restore my clarity and alleviated my forgetfulness.
Garlic
8.8
Improved brain pressure
Most Useful Review
Garlic is beneficial for immunity and cholesterol balance. I take it as my cholesterol levels were high and to relieve pressure in my brain. After a month of use, I have experienced improvements, alongside lecithin with omega and fermented brown rice!
9.5
Enhanced brain function
Most Useful Review
I've been using NOW Foods Concentrated Extract Odorless Garlic Gels 1000mg for several months and am thoroughly impressed with the results. The quality ingredients offer health benefits without the strong garlic odour. Since starting this supplement, I've seen an improvement in my blood pressure and brain function. It's fantastic to find a product that provides such significant advantages in a convenient form for those of us over 50. I highly recommend this supplement for anyone aiming to boost their overall health!
Iron
9
Iron nanoparticle imaging efficacy
A subtype specific probe for targeted magnetic resonance imaging of M2 tumor-associated macrophages in brain tumors.
Most Relevant Research
We explored the potential of using a specific type of iron nanoparticle to target and image a distinct group of immune cells known as M2 tumor-associated macrophages (TAMs) in brain tumors. These M2 TAMs can promote tumor growth and understanding their behavior could offer insights for better cancer treatments.
In our research, we developed a unique magnetic resonance imaging (MRI) probe composed of ultrafine iron oxide nanoparticles, which are small enough to avoid non-specific action in the body. We included a special peptide that actively seeks out M2 TAMs, allowing us to visualize them more clearly in mouse models of glioblastoma, a common and aggressive type of brain cancer.
The results were promising. The targeted nanoparticles showed a significant increase in accumulation within the tumors compared to standard nanoparticle formulations. This means that the M2-specific MRI probe provided a noticeable contrast in imaging, helping us differentiate areas of interest in the brain tumor environment better than conventional methods.
By demonstrating how effectively these iron nanoparticles can target specific immune cells, our study lays the groundwork for future research surrounding their use in cancer diagnostics and possibly in therapy. This could lead to improved strategies for tracking and altering the tumor environment as cancer progresses.
In our research, we developed a unique magnetic resonance imaging (MRI) probe composed of ultrafine iron oxide nanoparticles, which are small enough to avoid non-specific action in the body. We included a special peptide that actively seeks out M2 TAMs, allowing us to visualize them more clearly in mouse models of glioblastoma, a common and aggressive type of brain cancer.
The results were promising. The targeted nanoparticles showed a significant increase in accumulation within the tumors compared to standard nanoparticle formulations. This means that the M2-specific MRI probe provided a noticeable contrast in imaging, helping us differentiate areas of interest in the brain tumor environment better than conventional methods.
By demonstrating how effectively these iron nanoparticles can target specific immune cells, our study lays the groundwork for future research surrounding their use in cancer diagnostics and possibly in therapy. This could lead to improved strategies for tracking and altering the tumor environment as cancer progresses.
9.5
Itching resolved
Most Useful Review
Recently, even a single hair touching my face made me itchy, which worried me. I discovered that iron deficiency can cause itching and quickly bought this mineral supplement. I adore coffee, but the tannins in it inhibit iron absorption. Initially, I took double the amount of iron, but I learned that too much can harm the digestive tract, liver, heart, and brain, so I reduced my dosage. Since I began taking it, the itching disappeared. I plan to better organise my meals with iron in mind.
Enzymes
7
MitoQ inhibits glioma cell growth
Redox-crippled MitoQ potently inhibits breast cancer and glioma cell proliferation: A negative control for verifying the antioxidant mechanism of MitoQ in cancer and other oxidative pathologies.
Most Relevant Research
We explored the effects of MitoQ, a mitochondria-targeted version of coenzyme Q10, on brain tumors, particularly glioma cells. The aim was to understand how this compound influences cell growth and whether its properties can help counteract the harmful effects of oxidative stress often found in cancer.
In our experiments, we compared MitoQ with a modified compound called DM-MitoQ, which lacks the ability to engage in redox cycling, a crucial mechanism that allows MitoQ to function as an antioxidant. Surprisingly, DM-MitoQ displayed slightly greater potency in inhibiting the proliferation of breast cancer and glioma cells than MitoQ itself.
Both compounds were shown to significantly reduce oxygen consumption related to mitochondrial function, suggesting that their interference with energy production might play a crucial role in restricting cancer cell growth. Thus, our study implies that targeting mitochondrial processes could be vital in developing treatments for tough-to-treat tumors like gliomas.
Ultimately, we concluded that MitoQ's inhibition of mitochondrial oxidative phosphorylation could be pivotal in limiting brain tumor growth and spread. The findings also suggest that using DM-MitoQ may help us better understand the role of free radical processes in other cancer-related conditions.
In our experiments, we compared MitoQ with a modified compound called DM-MitoQ, which lacks the ability to engage in redox cycling, a crucial mechanism that allows MitoQ to function as an antioxidant. Surprisingly, DM-MitoQ displayed slightly greater potency in inhibiting the proliferation of breast cancer and glioma cells than MitoQ itself.
Both compounds were shown to significantly reduce oxygen consumption related to mitochondrial function, suggesting that their interference with energy production might play a crucial role in restricting cancer cell growth. Thus, our study implies that targeting mitochondrial processes could be vital in developing treatments for tough-to-treat tumors like gliomas.
Ultimately, we concluded that MitoQ's inhibition of mitochondrial oxidative phosphorylation could be pivotal in limiting brain tumor growth and spread. The findings also suggest that using DM-MitoQ may help us better understand the role of free radical processes in other cancer-related conditions.
9.5
Inflammation alleviated
Most Useful Review
My father takes Doctor's Best High Potency Serrapeptase and has experienced remarkable improvement seven months after major surgery. It has effectively reduced inflammation, and he reports that it cleared up the brain fog he was experiencing. After one month on serrapeptase, he feels alert and energetic again.
Quercetin
8.8
Cognitive enhancement
Most Useful Review
Quercetin is essential for maintaining good brain function, and I always order it here.
8.8
Brain aging prevention
Most Useful Review
This quercetin is excellent for the brain and lungs! It helps prevent aging and is crucial for lung health. I believe it's integral for both treating and preventing viral infections.
Vitamin Bs
7
Folate enhances brain cancer therapy
Folic Acid-Conjugated Brush Polymers Show Enhanced Blood-Brain Barrier Crossing in Static and Dynamic Models Toward Brain Cancer Targeting Therapy.
Most Relevant Research
We set out to investigate how folate could enhance the targeting of brain tumors using specially designed brush polymers. These polymers were modified to carry folic acid, which targets particular proteins on brain cell surfaces, effectively aiding in the delivery of treatments.
The researchers created these polymers by attaching folic acid to a brush polymer structure. This approach aimed to help the polymers cross the often challenging blood-brain barrier (BBB). We found that the folate-modified polymers significantly increased their uptake by brain endothelial cells, compared to non-modified versions.
To assess their effectiveness, we examined how well these polymers could cross models of the BBB and deliver therapy to glioblastoma cells after passing through. The results indicated that the more folate units incorporated into the polymers, the better they were at accumulating in glioma cells after crossing the BBB.
Overall, our findings suggest that these folate-modified brush polymers show great promise for improving the delivery of therapies aimed at treating brain cancers, making it a noteworthy advancement in the field.
The researchers created these polymers by attaching folic acid to a brush polymer structure. This approach aimed to help the polymers cross the often challenging blood-brain barrier (BBB). We found that the folate-modified polymers significantly increased their uptake by brain endothelial cells, compared to non-modified versions.
To assess their effectiveness, we examined how well these polymers could cross models of the BBB and deliver therapy to glioblastoma cells after passing through. The results indicated that the more folate units incorporated into the polymers, the better they were at accumulating in glioma cells after crossing the BBB.
Overall, our findings suggest that these folate-modified brush polymers show great promise for improving the delivery of therapies aimed at treating brain cancers, making it a noteworthy advancement in the field.
9.5
Essential for development
Most Useful Review
The folic acid dosage is very good. I began taking it in hopes of getting pregnant, and the results were swift, as I conceived in nearly two months. Before taking the pills, it did not work for over seven months. During pregnancy, folic acid is crucial for the development of the child, especially the brain and spinal cord. A deficiency can lead to severe consequences, including potential psychoses or mental retardation in the child.
L Carnosine
9
Mood and memory improved
Most Useful Review
I was introduced to carnosine by my dietician while managing a diet that affected my memory. Within weeks of taking it, my mood improved significantly, and I no longer experienced fatigue or sluggishness. This product remarkably enhanced my cognitive functions and I highly recommend it for maintaining brain health.
9.3
Improved brain function
Most Useful Review
This supplement has shown remarkable results for my nephew with autism. Alongside lipoic acid and DHA, carnosine has significantly boosted his condition within days. My wife and I have decided to take it too as a preventive measure against Alzheimer's.
Spirulina
9.5
Rich in nutrients
Most Useful Review
Spirulina is an impressive alga I consume daily, taking three tablets with each meal. Its remarkable nutrient profile includes protein, vitamins, and essential minerals, all of which contribute to developing healthy nervous tissue. It’s also a superior source of beta-carotene, providing protective benefits for the brain and eyes.
8.8
Clearer head
Most Useful Review
I felt the effect on my body by the third to fourth day. I began taking it during a stage of severe physical exhaustion and an upset stomach. The first thing I noticed was that my mind felt clearer, as if the fog had dissipated and the cobwebs had been cleared from my head. I am extremely grateful for this alone, as I hadn’t been able to gather my thoughts for a month. Additionally, my body has also improved, alongside a proper diet and sleep.
Inositol
8
Inositol treatment for brain tumors
Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation.
Most Relevant Research
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
9.5
Calms nerves effectively
Most Useful Review
Inositol is beneficial for brain circuits and the nervous system. It effectively treats sleep disorders at dosages between 500 to 1500 mg daily. I noticed a significant reduction in nervousness after using it for a couple of weeks. It’s also helpful for calming children who may be restless or anxious.
Taurine
9.5
Improved memory function
Most Useful Review
I have been treating a brain tumor for two years (it was stage 4). I drink taurine regularly; it is essential for normal liver function and detoxification. It also improves metabolism and stimulates new cell growth in the hippocampus, enhancing memory. In post-COVID times, memory loss is prevalent, making this relevant. In those two years, combining taurine with SAM-e, milk thistle and herbs helped regress fibrosis from stage 4 to 1. My depression has lifted, and I've overcome anxiety! I sleep well and no longer experience panic attacks. Taurine protects the liver and aids brain health — it truly is beneficial. If you found my review helpful, please give it a thumbs up.
9
Calming effects
Most Useful Review
Taurine is one of the best options for cardiovascular and brain health. It counteracts excessive neuroexcitory effects of glutamate, calming you down, making it perfect before interviews. I take one to two grams daily to elevate GABA levels for its antianxiolytic effect.
Phosphatidylserine
9.5
Highly recommended
Most Useful Review
Jarrow PS-100 was recommended to me years ago by a friend with a PhD in biochemistry who owns a vitamin store. It works wonders for brain function.
8.8
Cognitive delay therapy
Most Useful Review
This drug is useful for enhancing brain function, and I prefer the gel capsule form for ease of consumption. While both powder and gel options are effective, my mother requires gel due to gastrointestinal issues. Phosphatidylserine levels can be affected by deficiencies in certain nutrients. Insufficient amounts can impair cognitive abilities and cause a depressed state. There is evidence that it may help delay dementia, particularly Alzheimer’s. I noticed improvements in memory and concentration within 30 days.
Fish Oil
8
DHA liposomes target glioblastoma effectively
Microfluidic-Derived Docosahexaenoic Acid Liposomes for Targeting Glioblastoma and Its Inflammatory Microenvironment.
Most Relevant Research
We investigated the role of docosahexaenoic acid (DHA) in targeting glioblastoma, a challenging brain tumor with limited treatment options. By utilizing a special technique to create DHA liposomes, we aimed to reduce the inflammatory environment surrounding the tumor. This innovative approach allowed for a targeted delivery of DHA to the affected areas.
Through our research, we observed that these DHA liposomes were quickly taken up by macrophages, a type of immune cell, without causing any harm to them. We also discovered that these liposomes significantly lowered the activity of genes associated with inflammation and decreased the release of key inflammatory cytokines in both stimulated macrophages and glioblastoma cells.
Interestingly, while the DHA liposomes showed effectiveness in regulating inflammation, they did not notably change the expression of a certain anti-inflammatory gene in macrophages. Furthermore, our findings indicated that using DHA in liposome form was more effective than administering it freely.
Overall, our study highlights a promising strategy for using DHA liposomes to target glioblastoma and its inflammatory microenvironment. This innovative approach could lead to new treatment options for patients facing this aggressive type of brain cancer.
Through our research, we observed that these DHA liposomes were quickly taken up by macrophages, a type of immune cell, without causing any harm to them. We also discovered that these liposomes significantly lowered the activity of genes associated with inflammation and decreased the release of key inflammatory cytokines in both stimulated macrophages and glioblastoma cells.
Interestingly, while the DHA liposomes showed effectiveness in regulating inflammation, they did not notably change the expression of a certain anti-inflammatory gene in macrophages. Furthermore, our findings indicated that using DHA in liposome form was more effective than administering it freely.
Overall, our study highlights a promising strategy for using DHA liposomes to target glioblastoma and its inflammatory microenvironment. This innovative approach could lead to new treatment options for patients facing this aggressive type of brain cancer.
9.5
Improved memory
Most Useful Review
Very effective! I experienced clarity and improved memory. By the second day, my brain felt much more active, and my speech was noticeably faster. I truly enjoy this product!
Lutein
8.5
Boosts brain energy
Most Useful Review
This product's quality is very good and the package size is manageable. The ingredients provide great energy for my brain and reduce my stress. I feel younger and my immunity has improved. It tastes delightful.
8
Improves skin condition
Most Useful Review
Recommend very good for skin and brain. Skin condition improves. Be aware there are contraindications.
Choline
8
Inositol treatment for brain tumors
Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation.
Most Relevant Research
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
9.5
Reduced headaches
Most Useful Review
This supplement aids in the correct transmission of nerve impulses in the body. Choline and inositol are essential B vitamins necessary for brain, nervous system health, and fatty acid metabolism. I combine these with True Calm and have found noticeable relaxation, with almost no daily headaches. My mind remains clear until evening, which greatly enhances my concentration and overall performance.
L Ornithine
8.8
Sharpens focus
Most Useful Review
I struggled with concentration due to what I believed was excess ammonia after protein intake. After just two days of taking ornithine, my brain felt clearer, and I was able to think more clearly. I take it throughout the day, finding it effective as one of the essential amino acids.
8.8
Increases alertness
Most Useful Review
I take this supplement to maintain liver health. It notably decreases brain fog while enhancing my concentration and energy levels. I find the standard-sized capsules easy to swallow, and there have been no unpleasant side effects.
Evening Primrose
9.5
Improved menstrual cycle
Most Useful Review
I wish to share my personal experience. After brain surgery and radiation, I encountered various issues, including painful periods. After a month of taking primrose, my menstrual cycle improved, and the pain diminished. I strongly recommend it for those experiencing painful periods or disrupted cycles.
9.5
Miraculous treatment effect
Most Useful Review
After using the medication, I experienced miraculous results, with all tumours and nodes dissolving by themselves. It is an excellent remedy for treating brain tumours.
Vitamin B6
8
Vitamin B6 as glioblastoma target
Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures.
Most Relevant Research
We explored the impact of the vitamin B6 pathway on glioblastoma, a challenging and aggressive brain cancer. Specifically, we assessed how different cell cultures—2D monolayers and 3D spheroids—responded to treatments that alter vitamin B6 levels. Through comprehensive metabolomics analysis, we found notable differences in the levels of vitamin B6-related metabolites between these two culture methods.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
Our key finding was that when we used hydralazine, a small molecule known to lower vitamin B6 levels, it induced cell death specifically in the 3D spheroid cultures of glioblastoma. This suggests a potential new therapeutic strategy targeting the vitamin B6 pathway could benefit glioblastoma treatment.
Thus, this study highlights a novel approach to tackle this aggressive cancer by focusing on the metabolic alterations within the tumor microenvironment, particularly through vitamin B6 modulation.
9.5
Reduces anxiety levels
Most Useful Review
This medication significantly improves my sleep and alleviates the persistent anxiety that troubled me. Now, I feel calm, and even my friends and family have noticed a dramatic change. This is due to 5-HTP enhancing the brain's serotonin production, leading to noticeable improvements in mood.
Protein
9
IL-19 targeting improves GBM treatment
IL-19 as a promising theranostic target to reprogram the glioblastoma immunosuppressive microenvironment.
Most Relevant Research
We explored the role of interleukin-19 (IL-19) in glioblastoma multiforme (GBM), a notoriously aggressive brain tumor. The study combined clinical data and genomic analysis to understand how IL-19 contributes to the tumor's immunosuppressive environment and its overall impact on patient survival.
By blocking IL-19 in mouse models, we observed significant tumor progression inhibition, even in cases where tumors are resistant to traditional chemotherapy. The research showed that this blockade reprograms the immune microenvironment, enhancing the presence of beneficial immune cells while decreasing those that support tumor growth.
Importantly, our findings revealed that IL-19 is part of a signaling pathway that promotes invasion and migration in GBM cells. We also developed a novel system using nanoparticles designed to target areas expressing IL-19 in brain tumors, which demonstrated promising results in visualizing these tumor regions with MRI.
Overall, our study suggests that targeting IL-19 could be a viable strategy not just for imaging but also for enhancing treatment efficacy against chemoresistant GBM cells.
By blocking IL-19 in mouse models, we observed significant tumor progression inhibition, even in cases where tumors are resistant to traditional chemotherapy. The research showed that this blockade reprograms the immune microenvironment, enhancing the presence of beneficial immune cells while decreasing those that support tumor growth.
Importantly, our findings revealed that IL-19 is part of a signaling pathway that promotes invasion and migration in GBM cells. We also developed a novel system using nanoparticles designed to target areas expressing IL-19 in brain tumors, which demonstrated promising results in visualizing these tumor regions with MRI.
Overall, our study suggests that targeting IL-19 could be a viable strategy not just for imaging but also for enhancing treatment efficacy against chemoresistant GBM cells.
9.5
Boosts brain health
Most Useful Review
Excellent, I use it all the time. The ingredients include wheat germ oil, which is not widely known. At 27 years old, I've found the oil’s thickness to be high and the packaging sufficient. The benefits align exactly with the claims. Omega is incredibly beneficial for brain health. I applied it to my hair, and it greatly improved dryness and frizz, enhancing its overall condition. It's also suitable for those with cholesterol issues. I honestly recommend it; it helps in removing melasma, spots, dark circles, and skin marks, and it pairs well with other oils.
Apple Pectin
8.8
Brain fog treatment
Most Useful Review
Apple pectin has been notable in dissipating brain fog. The BDNF it helps produce is crucial for repairing brain nerve cells, especially when dealing with issues like brain degeneration and strokes. It aids in prebiotics transforming into butyrate, which is exceptionally beneficial when addressing cognitive impairments and enhancing rehabilitation.
7.5
Memory support
Most Useful Review
This product effectively supports brain function and memory improvements while also ensuring proper intestinal health.
L Glutamine
8
Necessary nutrient
Most Useful Review
For the recovery of age-damaged brain function, I have come across information suggesting that it is a necessary nutrient. I have been consuming it to aid in the recovery of my brain's function due to aging.
Most Useful Review
Vitamin C
8
Vitamin C in integrative treatment
Oncothermia and Integrative Medicine-A Novel Paradigm for Infratentorial Meningioma Management: A Case Report With One-Year Follow-Up.
Most Relevant Research
We looked into the use of vitamin C as part of a broader treatment strategy for managing infratentorial meningiomas, a type of brain tumor. The approach involved multiple therapies, including oncothermia, ozone therapy, and homeopathy, in a 60-year-old male patient who was not a candidate for surgery.
Vitamin C was combined with these various therapies, making it challenging to determine its standalone impact on the tumor. Throughout the follow-up assessments, significant symptom relief and tumor size reduction were observed. However, because vitamin C was part of a multifaceted treatment plan, it's hard to say just how much it contributed on its own.
Overall, this case highlights the potential of integrative medicine in improving brain tumor management, but further studies are necessary to isolate the effects and benefits of vitamin C specifically. As it stands, we recognize the need for more detailed research to better understand how vitamin C can fit into the treatment landscape for brain tumors like infratentorial meningiomas.
Vitamin C was combined with these various therapies, making it challenging to determine its standalone impact on the tumor. Throughout the follow-up assessments, significant symptom relief and tumor size reduction were observed. However, because vitamin C was part of a multifaceted treatment plan, it's hard to say just how much it contributed on its own.
Overall, this case highlights the potential of integrative medicine in improving brain tumor management, but further studies are necessary to isolate the effects and benefits of vitamin C specifically. As it stands, we recognize the need for more detailed research to better understand how vitamin C can fit into the treatment landscape for brain tumors like infratentorial meningiomas.
9.5
Protects brain cells
Most Useful Review
Green tea is known to support cognition, aid in maintaining moderate weight, and protect against cellular damage. Its functional components may enhance brain function and cognitive health, thereby decreasing the risk of cognitive impairment in midlife and older adults. I wholeheartedly endorse it; I've been taking 1000mg daily for years.
