Calcium
9
We investigated the potential of 2D layered calcium disilicide nanoparticles (CSNs) to treat rheumatoid arthritis (RA) through their unique properties. CSNs are crafted using a straightforward method of aqueous exfoliation, and their hydrolysis generates several beneficial components including hydrogen gas, alkaline calcium hydroxide (Ca(OH)), and silica.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
9
Pain relief
Most Useful Review
2 people found this helpful
These vitamins REALLY WORK FOR ME! I’ve been taking them for about three weeks and can feel a difference in my body already. I suffer from osteoarthritis, particularly in my knees, and after some research, I found magnesium helps with inflammation. Since starting these vitamins, I've had no pain in my knees or feet and can work longer hours without throbbing pain!
B5
9
We investigated the potential of 2D layered calcium disilicide nanoparticles (CSNs) to treat rheumatoid arthritis (RA) through their unique properties. CSNs are crafted using a straightforward method of aqueous exfoliation, and their hydrolysis generates several beneficial components including hydrogen gas, alkaline calcium hydroxide (Ca(OH)), and silica.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
9
Long-lasting effects
Most Useful Review
My husband takes it alongside other medications for rheumatic arthritis. It helps and lasts a long time. I highly recommend it for purchase.👍☝️
Vitamin B
9
We investigated the potential of 2D layered calcium disilicide nanoparticles (CSNs) to treat rheumatoid arthritis (RA) through their unique properties. CSNs are crafted using a straightforward method of aqueous exfoliation, and their hydrolysis generates several beneficial components including hydrogen gas, alkaline calcium hydroxide (Ca(OH)), and silica.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
7.5
Relieves arthritis pain
Most Useful Review
The dietary supplement is relatively safe but could be cleaner. Pantothenic acid effectively relieves arthritis pain and supports overall health during illnesses.
Oregano Oil Supplements
8
We explored how carvacrol, a compound found in oregano, can help reduce inflammation in chondrocytes, which are important cells involved in arthritis. The study specifically looked at the effects of carvacrol on chondrocytes stimulated by interleukin 1β, a protein that promotes inflammation in osteoarthritis.
The findings were promising. Carvacrol showed potential by inhibiting the production of nitric oxide and prostaglandin E2, both of which play significant roles in the inflammatory response. Notably, we observed that carvacrol reduced the expression of certain proteins that are typically elevated during inflammation, specifically inducible NO synthase and cyclooxygenase.
Furthermore, the results indicated that carvacrol suppressed the activation of a key signaling pathway linked to inflammation—specifically, the nuclear factor κB pathway. Thus, it appears that carvacrol can effectively diminish the inflammatory processes associated with osteoarthritis.
In conclusion, these findings suggest that oregano, through its active compound carvacrol, might offer a natural therapeutic option for those suffering from arthritis.
The findings were promising. Carvacrol showed potential by inhibiting the production of nitric oxide and prostaglandin E2, both of which play significant roles in the inflammatory response. Notably, we observed that carvacrol reduced the expression of certain proteins that are typically elevated during inflammation, specifically inducible NO synthase and cyclooxygenase.
Furthermore, the results indicated that carvacrol suppressed the activation of a key signaling pathway linked to inflammation—specifically, the nuclear factor κB pathway. Thus, it appears that carvacrol can effectively diminish the inflammatory processes associated with osteoarthritis.
In conclusion, these findings suggest that oregano, through its active compound carvacrol, might offer a natural therapeutic option for those suffering from arthritis.
9
Pain relief observed
Most Useful Review
30 people found this helpful
Now Foods, Oregano Oil My mother has been using this, and all her pain has subsided in her fingers and toes. She is even giving it to her old dogs for their arthritis, and her vet approved it. She really appreciates this product and has my husband using it as well, who claims it helps him too.
Pumpkin Seeds Pepitas
8
Comparative effectiveness of IL-6 inhibitors
We aimed to explore the effectiveness of three different medications that target the interleukin-6 receptor (IL-6R) in treating rheumatoid arthritis (RA). These medications include subcutaneous sarilumab (SAR-SC), subcutaneous tocilizumab (TCZ-SC), and intravenous tocilizumab (TCZ-IV). Our study was designed as a multicenter cohort study, gathering data from patients in Japan over several years, focusing specifically on those who hadn’t previously received IL-6R inhibitors.
After treating patients for 24 weeks, we found that those taking SAR-SC experienced a statistically significant reduction in disease activity compared to those on TCZ-SC. This is exciting news for people with RA, as it suggests that SAR-SC could potentially offer better outcomes for initial treatment. However, when comparing TCZ-IV and TCZ-SC, we did not observe significant differences in effectiveness.
The findings underscore the importance of considering both the effectiveness and cost of treatment options. While SAR-SC seemed more effective, the pricing of medications, including TCZ-SC and its biosimilars, should be factored into treatment decisions. Overall, our research contributes valuable insights into how these protein treatments can influence the management of arthritis.
After treating patients for 24 weeks, we found that those taking SAR-SC experienced a statistically significant reduction in disease activity compared to those on TCZ-SC. This is exciting news for people with RA, as it suggests that SAR-SC could potentially offer better outcomes for initial treatment. However, when comparing TCZ-IV and TCZ-SC, we did not observe significant differences in effectiveness.
The findings underscore the importance of considering both the effectiveness and cost of treatment options. While SAR-SC seemed more effective, the pricing of medications, including TCZ-SC and its biosimilars, should be factored into treatment decisions. Overall, our research contributes valuable insights into how these protein treatments can influence the management of arthritis.
9
Beneficial for arthritis
Most Useful Review
1 people found this helpful
The quality is excellent. I have repurchased pumpkin seeds numerous times due to their anti-inflammatory effects, which benefit my periodontal disease and arthritis. They are natural and healthy, making them a long-time staple in my diet.
B3 Niacin
8
We aimed to understand the relationship between niacin intake and osteoarthritis (OA) by analyzing data from the National Health and Nutrition Examination Survey spanning from 1999 to 2018. With over 30,000 participants in the study and almost 2,000 diagnosed with osteoarthritis, we found some interesting results.
Our analysis used advanced statistical methods to explore how different levels of niacin intake affected the risk of developing OA. What we discovered was that higher niacin intake was consistently associated with a reduced risk of osteoarthritis. In fact, participants in the highest intake group had a remarkable 33% lower risk compared to those in the lowest intake group.
We also noticed that there’s a non-linear relationship; once we reach an inflection point in niacin intake, the way it impacts OA risk changes. The results were particularly striking in Non-Hispanic Black individuals and others in different racial groups.
Overall, this research suggests that by increasing the consumption of niacin-rich foods, we may be able to reduce the risk of developing osteoarthritis. However, further investigations are needed to confirm these findings and explore the potential of niacin as an effective dietary approach to OA prevention and treatment.
Our analysis used advanced statistical methods to explore how different levels of niacin intake affected the risk of developing OA. What we discovered was that higher niacin intake was consistently associated with a reduced risk of osteoarthritis. In fact, participants in the highest intake group had a remarkable 33% lower risk compared to those in the lowest intake group.
We also noticed that there’s a non-linear relationship; once we reach an inflection point in niacin intake, the way it impacts OA risk changes. The results were particularly striking in Non-Hispanic Black individuals and others in different racial groups.
Overall, this research suggests that by increasing the consumption of niacin-rich foods, we may be able to reduce the risk of developing osteoarthritis. However, further investigations are needed to confirm these findings and explore the potential of niacin as an effective dietary approach to OA prevention and treatment.
9
Provides arthritis relief
Most Useful Review
7 people found this helpful
Great for arthritis! The flush variety of niacin aids circulation and may reduce allergies. However, I appreciate the non-flush variant as it provides relief from arthritis without the discomfort. I find it essential for my mobility; I can hardly walk without it. It works brilliantly!
Zinc
9
We explored the potential benefits of a new treatment involving zinc ferrite nanoparticles (ZFN) for individuals suffering from gouty arthritis (GA). This form of arthritis can be painful and complex, affecting people of all ages. Traditional treatments often come with side effects, prompting a search for more effective and safer alternatives.
The study revealed that zinc ferrite nanoparticles have impressive anti-inflammatory and antioxidant properties, which can help in managing the symptoms of gouty arthritis. Through a combination of laboratory and animal studies, we observed that ZFN significantly reduced inflammation and oxidative stress. Interestingly, it appears to work by modifying critical pathways involved in inflammation, specifically by influencing the NF-κB pathway and the NLRP3 inflammasome, while also activating the Nrf2 pathway.
These findings suggest that ZFN could become a promising option for treating gouty arthritis, providing an innovative and biocompatible approach to therapy. By addressing inflammation at its source, zinc ferrite nanoparticles could offer a new ray of hope for those dealing with GA, showcasing the potential for nanotechnology in improving health outcomes.
The study revealed that zinc ferrite nanoparticles have impressive anti-inflammatory and antioxidant properties, which can help in managing the symptoms of gouty arthritis. Through a combination of laboratory and animal studies, we observed that ZFN significantly reduced inflammation and oxidative stress. Interestingly, it appears to work by modifying critical pathways involved in inflammation, specifically by influencing the NF-κB pathway and the NLRP3 inflammasome, while also activating the Nrf2 pathway.
These findings suggest that ZFN could become a promising option for treating gouty arthritis, providing an innovative and biocompatible approach to therapy. By addressing inflammation at its source, zinc ferrite nanoparticles could offer a new ray of hope for those dealing with GA, showcasing the potential for nanotechnology in improving health outcomes.
9
Remarkable improvement
Most Useful Review
92 people found this helpful
My father struggled to get around due to arthritis and eventually needed a walker. After taking this vitamin daily for two weeks, he could walk unaided. My husband also takes this vitamin; whenever he feels unwell, he takes it and within 24 hours, he feels normal again.
Magnesium
8
Magnesium benefits for osteoarthritis
Our exploration focused on how magnesium can aid in treating the challenges associated with osteoarthritis, such as inflammation and cartilage degeneration. We synthesized a special carrier made from a combination of gallic acid and magnesium, designed to deliver a drug called puerarin effectively. This innovative approach involved forming hybrid microspheres that can be injected into the joint space.
During our tests, we noted that these magnesium-infused microspheres not only helped to release the drug over a longer period— extending beyond two weeks but they also positively affected the joint environment by reducing inflammation and oxidative stress. This means that magnesium, when combined with other components, can support overall joint health and promote cartilage repair.
In our in vivo experiments, we saw significant reductions in osteophyte formation and noticeable improvements in cartilage conditions, leading to a delay in the progression of osteoarthritis. Overall, these findings suggest that this magnesium-based delivery system could be an exciting avenue for enhancing treatment options for those suffering from osteoarthritis.
During our tests, we noted that these magnesium-infused microspheres not only helped to release the drug over a longer period— extending beyond two weeks but they also positively affected the joint environment by reducing inflammation and oxidative stress. This means that magnesium, when combined with other components, can support overall joint health and promote cartilage repair.
In our in vivo experiments, we saw significant reductions in osteophyte formation and noticeable improvements in cartilage conditions, leading to a delay in the progression of osteoarthritis. Overall, these findings suggest that this magnesium-based delivery system could be an exciting avenue for enhancing treatment options for those suffering from osteoarthritis.
9.5
Effective pain relief
Most Useful Review
26 people found this helpful
I recommend this supplement for arthritis in the knees. After enduring several surgeries and experiencing unbearable pain, I noticed an unbelievable difference just four days after starting this supplement. It provided me with significant relief, better than any painkiller I’ve tried, and restored my knee movement. I truly wish I’d discovered this 40 years ago.
Turmeric Curcumin
9
We delved into the effects of curcumin, particularly through a method called photodynamic therapy (CUR-PDT), in the context of rheumatoid arthritis. The research focused on how this treatment might trigger a specific type of cell death known as ferroptosis in fibroblast-like synoviocytes (FLSs), which are key players in arthritis inflammation.
Our study incorporated both in vivo and in vitro methods. In the animal model, we observed that CUR-PDT helped reduce joint swelling and associated inflammation. We also looked closely at how this treatment affected specific markers within FLSs, particularly focusing on the Nrf2/xCT/GPX4 signaling pathway. This pathway is crucial because it helps regulate responses to oxidative stress—something that can be detrimental in arthritis.
Through various tests, including measuring cell viability and cell responses to oxidative stress, we found that CUR-PDT effectively induced ferroptosis in the FLSs. This led to decreased cell proliferation and therefore suggests a potential avenue for treating rheumatoid arthritis more effectively. Although our findings show promising results regarding curcumin's role, it is important to emphasize that these effects stemmed more from the method of photodynamic therapy than solely from curcumin itself.
Overall, this research shines a light on the importance of understanding how curcumin, when utilized in specific therapeutic approaches, may contribute to better managing rheumatoid arthritis. However, the exact applications and benefits still require further exploration.
Our study incorporated both in vivo and in vitro methods. In the animal model, we observed that CUR-PDT helped reduce joint swelling and associated inflammation. We also looked closely at how this treatment affected specific markers within FLSs, particularly focusing on the Nrf2/xCT/GPX4 signaling pathway. This pathway is crucial because it helps regulate responses to oxidative stress—something that can be detrimental in arthritis.
Through various tests, including measuring cell viability and cell responses to oxidative stress, we found that CUR-PDT effectively induced ferroptosis in the FLSs. This led to decreased cell proliferation and therefore suggests a potential avenue for treating rheumatoid arthritis more effectively. Although our findings show promising results regarding curcumin's role, it is important to emphasize that these effects stemmed more from the method of photodynamic therapy than solely from curcumin itself.
Overall, this research shines a light on the importance of understanding how curcumin, when utilized in specific therapeutic approaches, may contribute to better managing rheumatoid arthritis. However, the exact applications and benefits still require further exploration.
9
Pain relief
Most Useful Review
37 people found this helpful
Fantastic supplement for arthritis sufferers! I have rheumatoid arthritis in my wrists and knees. I've taken Jarrow and Now brands Curcumin for months, which has significantly reduced my pain and flare-ups. I recently tried the Bio form of Curcumin, and it felt miraculous. Post-taking, I experienced a surge in energy, but beware of overdoing it as I did. Thanks iHerb for the great prices and fresh supplements.
Calcium Magnesium
9
We investigated the potential of 2D layered calcium disilicide nanoparticles (CSNs) to treat rheumatoid arthritis (RA) through their unique properties. CSNs are crafted using a straightforward method of aqueous exfoliation, and their hydrolysis generates several beneficial components including hydrogen gas, alkaline calcium hydroxide (Ca(OH)), and silica.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
These components support healing by improving anti-oxidation and reducing inflammation while promoting bone regeneration. The hydrogen gas helps eliminate harmful radicals and can alter macrophage behavior, which is crucial for regulating inflammation. Meanwhile, calcium hydroxide works to balance the acidic environment in the joints, limiting the harmful activity of osteoclasts, the cells that break down bone.
Furthermore, the calcium released can bind with phosphates, aiding in the formation of calcium phosphate, which is essential for bone mineralization. We confirmed these multifaceted benefits through tests on arthritic mice and rabbits, demonstrating that CSNs can provide a promising, biocompatible treatment strategy that enhances therapy beyond just addressing inflammation.
This study emphasizes the importance of calcium and its interactive role in more comprehensive arthritis treatments, fostering both anti-inflammatory and pro-osteogenic effects vital for joint health.
9
Significant pain relief
Most Useful Review
14 people found this helpful
Very effective calcium! I've previously tried pharmaceutical calcium products, but this one truly surprised me. I took it with vitamin D3 for my knee and hip joint issues stemming from a meniscus operation. After consuming half a jar, I experienced incredible relief. I used to hobble, but now I can run slowly every day. The frequent pain has vanished, and I’m delighted. Despite scepticism towards reviews like this, I’m now sharing my own. I’ve forgotten about my arthritis and took this for myself as well.
Quercetin
8
We conducted a systematic review and network meta-analysis to assess the effectiveness of quercetin and other plant active substances for treating rheumatoid arthritis (RA). Our findings revealed that quercetin particularly stands out for its ability to reduce pain and inflammation, as measured by the Visual Analogue Scale (VAS).
In our analysis, quercetin was shown to be effective in alleviating symptoms, making it a potentially valuable option for individuals suffering from RA. However, while we observed these positive effects, it's important to note that quercetin's benefits are often considered alongside other treatments, making it difficult to isolate its specific impact.
Overall, our research highlights the promise of quercetin in managing rheumatoid arthritis, but we also stress the need for additional studies to further confirm and clarify these effects. We believe that this information can help patients and healthcare providers make more informed decisions about using plant-based therapies in RA treatment.
In our analysis, quercetin was shown to be effective in alleviating symptoms, making it a potentially valuable option for individuals suffering from RA. However, while we observed these positive effects, it's important to note that quercetin's benefits are often considered alongside other treatments, making it difficult to isolate its specific impact.
Overall, our research highlights the promise of quercetin in managing rheumatoid arthritis, but we also stress the need for additional studies to further confirm and clarify these effects. We believe that this information can help patients and healthcare providers make more informed decisions about using plant-based therapies in RA treatment.
9
Significant relief
Most Useful Review
119 people found this helpful
Quercetin and bromelain are potent natural ingredients that alleviate allergic and inflammatory disorders, including arthritis. They help mitigate asthma, eczema, and other conditions. As someone suffering from arthritis, Raynaud's syndrome, and various allergies, I find Quercetin a real lifesaver. I take it regularly and wholeheartedly recommend it!
L Glutathione
8
Silymarin shows potential for arthritis
We explored the potential benefits of silymarin and silibinin for managing rheumatoid arthritis (RA) and osteoarthritis (OA) symptoms through a systematic review of 21 relevant studies.
The findings suggested that these compounds exhibit anti-inflammatory and antioxidant qualities, which could help protect joints from damage.
However, while the results are promising, more clinical research is necessary to confirm their effectiveness and establish guidance for their use in patients.
The findings suggested that these compounds exhibit anti-inflammatory and antioxidant qualities, which could help protect joints from damage.
However, while the results are promising, more clinical research is necessary to confirm their effectiveness and establish guidance for their use in patients.
7.5
Knee pain relief
Most Useful Review
6 people found this helpful
I'm delighted to share my review on the 30 tablets I purchased. The results were so impressive that I ordered another 60 tablets. Initially bought to improve my skin, I noticed after about 15 days that my knee pain, shoulder pain related to osteoarthritis, and resting pain in my shoulder blades and arms from cervical spondylotic radiculopathy completely disappeared. I was astonished by the unexpected effects of the glutathione and peony mochi! While I still feel some pain when moving, the resting pain has vanished, allowing me to sleep very well. My hands have also become much fairer.
Vitamins
8
Calcitriol impacts immune response in RA
We explored the effects of calcitriol, the active form of vitamin D3, on mesenchymal stem cells (MSCs) and their potential to influence rheumatoid arthritis (RA) in a mouse model. Using a well-structured study design, we induced RA in BALB/c mice and divided them into three groups: one group received untreated MSCs, another received calcitriol-treated MSCs, while the third group received no treatment at all. After the treatment, we assessed various immune responses and inflammatory mediators.
Our findings revealed that the calcitriol-treated MSCs significantly outperformed untreated MSCs in regulating immune responses. Specifically, we noted improvements in the function of innate immune cells, particularly splenocytes. These cells showed enhanced regulatory abilities, which led to a decrease in pro-inflammatory cytokines like IL-17 and an increase in anti-inflammatory cytokines such as IL-4 and IL-10. This suggests that calcitriol may play a crucial role in modulating the immune response in RA.
However, while the study shows encouraging results for calcitriol-treated MSCs in reducing inflammation, it’s important to note that this research is still in the early stages and primarily conducted in a controlled laboratory environment. Further studies are needed to determine how these findings translate to human treatment outcomes.
Our findings revealed that the calcitriol-treated MSCs significantly outperformed untreated MSCs in regulating immune responses. Specifically, we noted improvements in the function of innate immune cells, particularly splenocytes. These cells showed enhanced regulatory abilities, which led to a decrease in pro-inflammatory cytokines like IL-17 and an increase in anti-inflammatory cytokines such as IL-4 and IL-10. This suggests that calcitriol may play a crucial role in modulating the immune response in RA.
However, while the study shows encouraging results for calcitriol-treated MSCs in reducing inflammation, it’s important to note that this research is still in the early stages and primarily conducted in a controlled laboratory environment. Further studies are needed to determine how these findings translate to human treatment outcomes.
9
Joint pain relief
Most Useful Review
1 people found this helpful
In one capsule, not only essential vitamin C, but also rutin and bioflavonoids. Rutin is known for its protective role for ascorbic acid (vitamin C) due to its antioxidant properties, which fend off excessive oxidation. Preparations from sophora are recommended for strengthening blood vessels. I have arthritis and can definitely say that my joints have become much less painful. This vitamin is particularly useful during heightened virus activity. My whole family takes it as an additional source of body protection, and we rarely suffer from respiratory illnesses. I appreciate the convenient dosage and reasonable pricing of this company's products, and I wholeheartedly recommend it.
Garlic
8
Garlic extract aids osteoarthritis treatment
We explored how diallyl disulfide (DADS), a component found in garlic oil, affects osteoarthritis (OA) in a study on rats. The research involved thirty-four female Sprague-Dawley rats, with some undergoing a surgery to induce OA, while others had a sham procedure. After six weeks, we administered DADS in hydrogel through a knee joint injection to some of the OA rats while others received a vehicle solution or saline for comparison.
Over the following weeks, we observed significant benefits in the rats treated with DADS. The results indicated that DADS not only improved cartilage health but also helped in maintaining the bone structure beneath the cartilage. This suggests that garlic, in the form of a concentrated extract, could have a protective effect against early OA progression, which is particularly relevant for postmenopausal women predisposed to this joint condition.
Our findings reveal a potential new avenue in OA treatment through natural extracts, highlighting the importance of garlic and its derivatives in supporting joint health. While this research primarily focuses on animal models, it opens up exciting possibilities for further studies in humans.
Over the following weeks, we observed significant benefits in the rats treated with DADS. The results indicated that DADS not only improved cartilage health but also helped in maintaining the bone structure beneath the cartilage. This suggests that garlic, in the form of a concentrated extract, could have a protective effect against early OA progression, which is particularly relevant for postmenopausal women predisposed to this joint condition.
Our findings reveal a potential new avenue in OA treatment through natural extracts, highlighting the importance of garlic and its derivatives in supporting joint health. While this research primarily focuses on animal models, it opens up exciting possibilities for further studies in humans.
9
Consistently excellent
Most Useful Review
Excellent product and service, as always. It's particularly beneficial for managing my arthritis.
Enzymes
8
Examining how Coenzyme Q10 (CoQ10) affects arthritis is crucial given its potential as a treatment option. We reviewed twenty articles published between 1966 and April 2023, encompassing a total of 483 participants. The focus was primarily on Rheumatoid Arthritis (RA), alongside Fibromyalgia (FM) and Antiphospholipid Syndrome (APS).
Our findings indicate that CoQ10 supplementation has shown promising results for RA patients. Improvements were observed in key areas such as disease activity, inflammatory markers, and even cytokine levels, marking a positive shift in health. Additionally, fibromyalgia patients reported better management of pain, fatigue, and sleep quality, along with enhanced mood and tender point counts. This suggests a broader application of CoQ10 beyond just arthritis.
We also noted that CoQ10 was generally well tolerated among patients, with only minimal side effects reported. Therefore, incorporating CoQ10 might serve as an effective complementary therapy for those dealing with RA and FM. Future studies with larger sample sizes and diverse rheumatic conditions would be beneficial to further validate these findings.
Our findings indicate that CoQ10 supplementation has shown promising results for RA patients. Improvements were observed in key areas such as disease activity, inflammatory markers, and even cytokine levels, marking a positive shift in health. Additionally, fibromyalgia patients reported better management of pain, fatigue, and sleep quality, along with enhanced mood and tender point counts. This suggests a broader application of CoQ10 beyond just arthritis.
We also noted that CoQ10 was generally well tolerated among patients, with only minimal side effects reported. Therefore, incorporating CoQ10 might serve as an effective complementary therapy for those dealing with RA and FM. Future studies with larger sample sizes and diverse rheumatic conditions would be beneficial to further validate these findings.
9
Improves mobility
Most Useful Review
120 people found this helpful
I included enzyme therapy in my book on chronic illness. Serrapeptase, a powerful anti-inflammatory, has noticeably improved my knee joint mobility and reduced chronic inflammation after six weeks. I appreciate the potency and value of this product, which has proven effective against issues like arthritis.
Boron
9
This study explored a cutting-edge strategy using nanoparticles wrapped in macrophage membranes to treat rheumatoid arthritis.
The nanoparticles, designed to release 2-APB specifically in inflamed joints, successfully repolarized inflammatory macrophages, leading to reduced inflammation and joint damage in mouse models.
Overall, this innovative approach appears safe and effective, holding potential for better, targeted therapies for rheumatoid arthritis.
The nanoparticles, designed to release 2-APB specifically in inflamed joints, successfully repolarized inflammatory macrophages, leading to reduced inflammation and joint damage in mouse models.
Overall, this innovative approach appears safe and effective, holding potential for better, targeted therapies for rheumatoid arthritis.
8
Minimises arthritis effects
Most Useful Review
3 people found this helpful
I take Boron to reduce the effects of arthritis, primarily in my hands. It appears to be effective where nothing else has helped. The delivery was timely as I was running low on capsules. It’s a good quality product, and Boron, being a mineral, is essential.
Milk Thistle Silymarin
8
Silymarin shows potential for arthritis
We explored the potential benefits of silymarin and silibinin for managing rheumatoid arthritis (RA) and osteoarthritis (OA) symptoms through a systematic review of 21 relevant studies.
The findings suggested that these compounds exhibit anti-inflammatory and antioxidant qualities, which could help protect joints from damage.
However, while the results are promising, more clinical research is necessary to confirm their effectiveness and establish guidance for their use in patients.
The findings suggested that these compounds exhibit anti-inflammatory and antioxidant qualities, which could help protect joints from damage.
However, while the results are promising, more clinical research is necessary to confirm their effectiveness and establish guidance for their use in patients.
7.5
Reduced pain effectively
Most Useful Review
8 people found this helpful
Working. I have to take various supplements and medications due to arthritis. It's tough on my liver, but after a week of this product, I noticed a reduction in both weight and pain. I recommend it.
Hyaluronic Acid
9
Hyaluronic acid's long-term effects unclear
We dug into the effectiveness of hyaluronic acid (HA) as a treatment for knee osteoarthritis (OA). By examining data from 37 randomized controlled trials involving over 5,000 patients, we aimed to understand how well HA works in providing pain relief and improving knee function over the long term.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
9
Effective for arthritis
Most Useful Review
102 people found this helpful
A worthy competitor to medicinal chondroprotectors! The order arrived in 4 days, well packed, with the product matching the description and expiry date. The capsules are medium-sized, easy to take, and have a yeasty smell. I find this medication beneficial for my arthritis; the crunch in my knee joint disappears, and any discomfort subsides during exertion. My skin feels more hydrated, and fine wrinkles are less apparent. The convenient dosage of 100mg, when combined with adequate hydration and vitamin C, proves effective.
Glucosamine Chondroitin Formulas
8
Glucosamine and exercise enhance arthritis treatment
We sought to determine whether a combination of a nutrition supplement, including glucosamine and chondroitin, along with supervised exercise, is more effective for knee osteoarthritis than exercise alone.
In a six-month double-blinded trial involving 65 participants, those who took the supplement experienced significant improvements in pain and stiffness earlier compared to those receiving a placebo.
This suggests that using glucosamine chondroitin supplementation along with exercise could be a more efficient treatment strategy for arthritis in the knee.
In a six-month double-blinded trial involving 65 participants, those who took the supplement experienced significant improvements in pain and stiffness earlier compared to those receiving a placebo.
This suggests that using glucosamine chondroitin supplementation along with exercise could be a more efficient treatment strategy for arthritis in the knee.
9
Knee pain relief
Most Useful Review
383 people found this helpful
Mum had severe knee joint pain when walking, and after a month of taking chondroprotectors, the pain disappeared. I ordered different brands, and this one from NOW seemed most effective. For added efficiency, I also got Boswellia extract, which I highly recommend.
Folic Acid
9
We investigated the effects of folic acid on chronic inflammatory pain, especially in the context of arthritis. Adult rats were used in our study, and we induced inflammatory pain by injecting a substance called complete Freund's adjuvant (CFA) into their hind paws. Through behavioral tests, we assessed pain responses by measuring how long it took for the rats to withdraw their paws from painful stimuli.
Our findings showed that the CFA injections not only caused significant pain but also increased the expression of Matrix metalloproteinase 2 (MMP2), a protein associated with inflammation. Notably, MMP2 was primarily found in nerve cells rather than glial cells, indicating its crucial role in the pain pathway.
In an exciting twist, we discovered that long-term treatment with folic acid managed to reduce the overexpression of MMP2. This led to lasting relief from chronic inflammatory pain for the rats and also alleviated pain-related anxiety. These results suggest that folic acid could be a promising therapeutic option for managing chronic inflammatory pain and anxiety in arthritis patients, allowing for better pain management in the long term.
Our findings showed that the CFA injections not only caused significant pain but also increased the expression of Matrix metalloproteinase 2 (MMP2), a protein associated with inflammation. Notably, MMP2 was primarily found in nerve cells rather than glial cells, indicating its crucial role in the pain pathway.
In an exciting twist, we discovered that long-term treatment with folic acid managed to reduce the overexpression of MMP2. This led to lasting relief from chronic inflammatory pain for the rats and also alleviated pain-related anxiety. These results suggest that folic acid could be a promising therapeutic option for managing chronic inflammatory pain and anxiety in arthritis patients, allowing for better pain management in the long term.
9
Excellent quality
Most Useful Review
Excellent! This supplement is ideal for anyone with immune diseases. My mother suffers from rheumatoid arthritis, and it’s of high quality. It should not be cut.
Vitamin D
8
We explored the effects of vitamin D supplementation on adults with rheumatoid arthritis (RA), an inflammatory condition affecting millions worldwide. By examining clinical studies that compared vitamin D to either a placebo or standard care, we focused on how these supplements might influence various health outcomes for those suffering from RA.
Our analysis included 11 studies, highlighting several noteworthy findings. We observed a significant improvement in key measures: the Disease Activity Score 28 (DAS-28) showed a meaningful reduction, while levels of C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) also decreased. Furthermore, vitamin D supplementation led to an increase in serum vitamin D levels.
Despite these positive results, vitamin D supplementation did not appear to significantly impact the health assessment questionnaire (HAQ) and visual analog scale for pain (VAS-pain) scores. Consequently, while vitamin D can help reduce inflammation and improve specific health parameters in RA patients, the optimal dosage and duration of treatment remain unclear.
Overall, our findings suggest that boosting vitamin D levels might offer benefits for managing RA, and further research may help refine treatment strategies for optimal outcomes.
Our analysis included 11 studies, highlighting several noteworthy findings. We observed a significant improvement in key measures: the Disease Activity Score 28 (DAS-28) showed a meaningful reduction, while levels of C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) also decreased. Furthermore, vitamin D supplementation led to an increase in serum vitamin D levels.
Despite these positive results, vitamin D supplementation did not appear to significantly impact the health assessment questionnaire (HAQ) and visual analog scale for pain (VAS-pain) scores. Consequently, while vitamin D can help reduce inflammation and improve specific health parameters in RA patients, the optimal dosage and duration of treatment remain unclear.
Overall, our findings suggest that boosting vitamin D levels might offer benefits for managing RA, and further research may help refine treatment strategies for optimal outcomes.
9
Improved arthritis symptoms
Most Useful Review
50 people found this helpful
This is a superb product that has substantially improved my health and well-being. My mood has enhanced, and I no longer require medication for my arthritis. It's also been incredibly helpful during severe colds or flu.
Cod Liver Oil
7
We explored how the use of cod liver oil could impact the daily intake of Diclofenac Sodium for people with rheumatoid arthritis. In a recent study conducted over 24 weeks, 30 participants aged 19 to 60 received five cod liver oil capsules twice daily while switching from various anti-inflammatory medications to a maximum dose of 200 mg of Diclofenac Sodium.
Throughout the study, we monitored the participants' pain levels using the Visual Analogue Scale and recorded their daily Diclofenac usage. The results indicated a reduction in the average daily dosage of Diclofenac, suggesting that cod liver oil might help to lessen the need for this medication.
This finding is particularly relevant as Diclofenac is commonly used but can lead to adverse side effects. By incorporating cod liver oil—which is rich in essential fatty acids—into their treatment regimen, patients may enjoy improved management of their arthritis symptoms and potentially decrease their intake of Diclofenac.
In conclusion, our study suggests that cod liver oil can play a beneficial role in arthritis care by reducing the reliance on Diclofenac Sodium and possibly mitigating its side effects. This could pave the way for developing more holistic approaches to managing rheumatoid arthritis.
Throughout the study, we monitored the participants' pain levels using the Visual Analogue Scale and recorded their daily Diclofenac usage. The results indicated a reduction in the average daily dosage of Diclofenac, suggesting that cod liver oil might help to lessen the need for this medication.
This finding is particularly relevant as Diclofenac is commonly used but can lead to adverse side effects. By incorporating cod liver oil—which is rich in essential fatty acids—into their treatment regimen, patients may enjoy improved management of their arthritis symptoms and potentially decrease their intake of Diclofenac.
In conclusion, our study suggests that cod liver oil can play a beneficial role in arthritis care by reducing the reliance on Diclofenac Sodium and possibly mitigating its side effects. This could pave the way for developing more holistic approaches to managing rheumatoid arthritis.
9
Pain relief
Most Useful Review
2 people found this helpful
I broke both my feet in my youth, resulting in significant arthritis. Since I began taking cod liver oil three months ago, it has alleviated most of the pain in my feet and improved my overall wellbeing.
Glucosamine
7
Glucosamine improves knee osteoarthritis
We examined the effects of glucosamine, chondroitin, and other symptomatic slow-acting drugs on knee osteoarthritis.
Analyzing 21 clinical trials, we found that patients treated with these compounds experienced better pain relief and functional improvements compared to those on placebo, especially noticeable within the first three months.
Interestingly, the results showed no significant difference in effectiveness when comparing these treatments to non-placebo medications.
Overall, glucosamine and its counterparts are safe and effective options for managing knee OA symptoms.
Analyzing 21 clinical trials, we found that patients treated with these compounds experienced better pain relief and functional improvements compared to those on placebo, especially noticeable within the first three months.
Interestingly, the results showed no significant difference in effectiveness when comparing these treatments to non-placebo medications.
Overall, glucosamine and its counterparts are safe and effective options for managing knee OA symptoms.
9
Significant pain relief
Most Useful Review
6 people found this helpful
This is the first supplement that has truly improved my shoulder pain stemming from post-traumatic shoulder arthritis. Initially sceptical due to past failures with other products, I noticed a significant improvement after 3-4 weeks. I'm now almost pain-free and no longer need NSAIDs. I take 1.5g daily in the morning, increasing to 3g on more active days. Occasionally, I experience some reflux, which is manageable by taking the supplement with food. I highly recommend it to anyone suffering from arthritis, but patience is key as the effects take a few weeks to become apparent.
Gelatin
8
We explored how gelatin microspheres, made without glutaraldehyde, can be a game-changer for osteoarthritis (OA). By cultivating these microspheres with mesenchymal stem cells (MSCs), we found they promote the expression of important genes linked to cartilage growth.
Our study involved cartilage samples from OA patients, and we noted that these microspheres significantly improved MSC attachment and contributed to immune regulation. Ultimately, using gelatin microspheres may help alleviate OA symptoms, representing a novel therapeutic avenue for those suffering from this chronic joint condition.
Our study involved cartilage samples from OA patients, and we noted that these microspheres significantly improved MSC attachment and contributed to immune regulation. Ultimately, using gelatin microspheres may help alleviate OA symptoms, representing a novel therapeutic avenue for those suffering from this chronic joint condition.
9
Joint relief
Most Useful Review
5 people found this helpful
Gelatin is crucial for healthy hair, skin, and cartilage. It contains amino acids that are well absorbed, nourishing joints and relieving arthritis pain, while also improving mobility.
Omega 3 Fish Oil
8
We explored whether omega-3 fatty acids could help slow down osteoarthritis (OA) by changing how chondrocytes, the cells in our cartilage, respond to mechanical forces.
Our findings indicated that omega-3s significantly reduced chondrocyte sensitivity to compression and certain chemical signals linked to OA progression.
Interestingly, we also discovered that another type of fatty acid, omega-6, may actually make chondrocyte membranes more prone to damage.
This research showcases the importance of specific fatty acids in managing joint health and offers new ideas for nutritional strategies to combat OA.
Our findings indicated that omega-3s significantly reduced chondrocyte sensitivity to compression and certain chemical signals linked to OA progression.
Interestingly, we also discovered that another type of fatty acid, omega-6, may actually make chondrocyte membranes more prone to damage.
This research showcases the importance of specific fatty acids in managing joint health and offers new ideas for nutritional strategies to combat OA.
9
Joint pain relief
Most Useful Review
119 people found this helpful
I buy this Omega-3 for my mother, who suffers from arthritis. Since she began taking it in winter, her joint and muscle pain has significantly improved.
MSM
7
We explored how methylsulfonylmethane (MSM) compares to other treatments like methylprednisolone and hyaluronic acid in addressing ankle arthritis that stems from trauma, known as posttraumatic ankle osteoarthritis (PTAO). In our study, we monitored how 32 adult rats responded to different treatment methods over eight weeks. We divided them into four groups: one received MSM orally, while the others received injections of methylprednisolone or hyaluronic acid. The fourth group served as a control.
Our findings showed that both the methylprednisolone and MSM groups had better radiological results compared to the control group, indicating some effectiveness. However, when we assessed the severity of arthritis, the methylprednisolone group performed notably better than the hyaluronic acid group. Interestingly, we found no significant differences between the MSM and control groups in terms of histopathological changes, which raises questions about the efficacy of MSM on its own.
Additionally, there was no notable change in the range of motion among the groups, suggesting that while both MSM and methylprednisolone may slow the progression of arthritis, MSM might not offer substantial benefits compared to current treatment standards. This makes it clear that an honest review of treatment options in daily practice is needed.
Our findings showed that both the methylprednisolone and MSM groups had better radiological results compared to the control group, indicating some effectiveness. However, when we assessed the severity of arthritis, the methylprednisolone group performed notably better than the hyaluronic acid group. Interestingly, we found no significant differences between the MSM and control groups in terms of histopathological changes, which raises questions about the efficacy of MSM on its own.
Additionally, there was no notable change in the range of motion among the groups, suggesting that while both MSM and methylprednisolone may slow the progression of arthritis, MSM might not offer substantial benefits compared to current treatment standards. This makes it clear that an honest review of treatment options in daily practice is needed.
7.5
Reduces joint pain
Most Useful Review
61 people found this helpful
Very good additive! MSM is an organic sulphur compound with anti-inflammatory effects. I purchased it for my mother, who suffers from arthritis, and she has experienced some relief in her joint pain and sinus issues. I also tried it for my allergies, and it has significantly reduced my morning cough and improved my breathing. I even found relief from severe bloating that previous medications couldn't alleviate.
Collagen Supplements
9
We looked into how BD400 could potentially help with collagen-induced arthritis (CIA) in rats. Using a model to mimic the disease, we observed that BD400 significantly reduced arthritis scores and paw swelling.
It also decreased harmful inflammatory markers and improved gut health by enhancing intestinal barrier function. Essentially, BD400 seems to help alter gut bacteria and metabolism, which may slow down the progression of rheumatoid arthritis.
It also decreased harmful inflammatory markers and improved gut health by enhancing intestinal barrier function. Essentially, BD400 seems to help alter gut bacteria and metabolism, which may slow down the progression of rheumatoid arthritis.
9
Relief from joints
Most Useful Review
3 people found this helpful
I have rheumatoid arthritis, and this collagen is my saviour. After a month, my joints felt relief, and I strongly recommend it!
Bromelain
7
We observed that human synovial cells from osteoarthritis (OA) patients respond to lipopolysaccharide (LPS) by mimicking changes seen in inflamed joint tissues. Our study tested a unique blend of curcumin, bromelain, and harpagophytum for their potential to reduce inflammation.
The results showed that this combination of natural compounds has anti-inflammatory and anti-catabolic effects. This suggests they might help alleviate pain and slow the progression of OA, offering a glimpse of hope for those battling this common form of arthritis.
The results showed that this combination of natural compounds has anti-inflammatory and anti-catabolic effects. This suggests they might help alleviate pain and slow the progression of OA, offering a glimpse of hope for those battling this common form of arthritis.
9
Positive effects noted
Most Useful Review
Arthritis really works.
Dha
4
We explored the connection between plasma levels of 17-hydroxy-docosahexaenoic acid (17-HDHA), a compound that plays a role in resolving inflammation, and chronic pain in individuals with osteoarthritis. Our study involved participants with an average age of 62.3 years, where 60% were female, and included 30 individuals in total.
By assessing their 17-HDHA levels alongside their self-reported pain scores, we were able to analyze RNA from specialized monocytes, which are a type of white blood cell involved in immune responses. We used advanced sequencing techniques to identify differentially expressed mRNAs, revealing some interesting findings.
The analysis highlighted that the eukaryotic initiation factor 2 (EIF2) signaling pathway was significantly linked to the differences in pain experienced based on 17-HDHA levels. Specifically, those in the low 17-HDHA-high pain group had a lower activation level of this pathway compared to those with high 17-HDHA-low pain. This suggests that EIF2 signaling may play a role in both osteoclast activity and the process of pain in osteoarthritis.
While this study sheds light on the biological pathways underlying the relationship between 17-HDHA and pain, it does not conclusively determine the isolated effects of docosahexaenoic acid itself. However, it does open avenues for further exploration of potential treatments that might target these specific signaling pathways to alleviate pain in osteoarthritis.
By assessing their 17-HDHA levels alongside their self-reported pain scores, we were able to analyze RNA from specialized monocytes, which are a type of white blood cell involved in immune responses. We used advanced sequencing techniques to identify differentially expressed mRNAs, revealing some interesting findings.
The analysis highlighted that the eukaryotic initiation factor 2 (EIF2) signaling pathway was significantly linked to the differences in pain experienced based on 17-HDHA levels. Specifically, those in the low 17-HDHA-high pain group had a lower activation level of this pathway compared to those with high 17-HDHA-low pain. This suggests that EIF2 signaling may play a role in both osteoclast activity and the process of pain in osteoarthritis.
While this study sheds light on the biological pathways underlying the relationship between 17-HDHA and pain, it does not conclusively determine the isolated effects of docosahexaenoic acid itself. However, it does open avenues for further exploration of potential treatments that might target these specific signaling pathways to alleviate pain in osteoarthritis.
9
Arthritis improvement
Most Useful Review
1 people found this helpful
I highly recommend this Omega 3 package. It’s excellent for arthritis and heart health, with great taste and quality. It lowers cholesterol, improves lifespan, and has beneficial ingredients.
Elderberry Sambucus
7
Elderberry shows promise for arthritis
We explored the effectiveness of Dwarf Elder, or Sambucus ebulus, in treating knee osteoarthritis (OA) by conducting a randomized, double-blind clinical trial. In this study, we compared topical S. ebulus gel to a 1% diclofenac gel, known for its anti-inflammatory properties. Seventy-nine patients participated, applying the treatment three times a day for four weeks.
Throughout the trial, we measured changes in knee pain using a visual analogue scale and assessed functional improvements with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire.
Our findings suggest that topical S. ebulus gel might effectively ease knee OA symptoms. However, we noted that further research with larger groups is essential to confirm the long-term efficacy and safety of this natural remedy. Overall, while the initial results are promising, more extensive trials will provide a clearer perspective on the true potential of elderberry in managing knee osteoarthritis.
Throughout the trial, we measured changes in knee pain using a visual analogue scale and assessed functional improvements with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire.
Our findings suggest that topical S. ebulus gel might effectively ease knee OA symptoms. However, we noted that further research with larger groups is essential to confirm the long-term efficacy and safety of this natural remedy. Overall, while the initial results are promising, more extensive trials will provide a clearer perspective on the true potential of elderberry in managing knee osteoarthritis.
7.5
Immunity boost
Most Useful Review
10 people found this helpful
Elderberry helps improve immunity and is beneficial for colds and arthritis. I take 2 capsules with vitamin C and D, and echinacea to recover quickly. During a mild illness, elderberry proved invaluable. I believe it’s essential to have elderberry at home as a remedy for colds. I highly recommend it!
Evening Primrose Oil
9
We examined the impact of evening primrose oil combined with fish oil on patients with rheumatoid arthritis through a 12-week study involving 60 participants. The results showed that both fish oil and the combination with evening primrose oil led to significant improvements in symptoms, like reduced disease activity scores and fewer tender joints.
However, while evening primrose oil contributed positively, the study emphasized the notable benefits of omega-3 fatty acids alone as well. Overall, this suggests a potential pathway for improving arthritis symptoms through these supplements.
However, while evening primrose oil contributed positively, the study emphasized the notable benefits of omega-3 fatty acids alone as well. Overall, this suggests a potential pathway for improving arthritis symptoms through these supplements.
7.5
Improves arthritis symptoms
Most Useful Review
54 people found this helpful
This oil is fantastic! It’s rich in gamma-linolenic acid and helps alleviate menstrual and menopausal symptoms, skin issues, arthritis, and improves fertility. I've noticed an improvement in my skin's elasticity and moisture. For best results, it's advised to take the capsules for 12 weeks. Stay healthy!
Sports Fish Oil Omegas
8
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
7.5
Pain relief
Most Useful Review
115 people found this helpful
Despite the high price, I find this omega-3 to be the best available in terms of quality and ingredients. It effectively alleviates my arthritis pain when combined with vitamin D and curcumin, and even enhances my focus, which I had been losing due to my condition.
N Acetyl Glucosamine
8
Movardol® shows promise for OA
This registry study involved 54 individuals with moderate knee osteoarthritis. Participants chose between standard management and an enhanced treatment that included Movardol®, which contains N-acetyl-glucosamine, ginger, and Boswellia serrata.
Over six months, we assessed a range of outcomes, such as pain levels, mobility, and inflammatory markers. The preliminary findings suggest that Movardol® supplementation is both effective and safe for managing knee osteoarthritis symptoms.
Overall, this points to a promising option for those seeking relief from their condition.
Over six months, we assessed a range of outcomes, such as pain levels, mobility, and inflammatory markers. The preliminary findings suggest that Movardol® supplementation is both effective and safe for managing knee osteoarthritis symptoms.
Overall, this points to a promising option for those seeking relief from their condition.
9
Pain relief
Most Useful Review
15 people found this helpful
I discovered this supplement by chance on the iHerb website. I suffer from various food allergies, digestive issues, and arthritis. After a difficult weekend with an upset stomach and aching arthritis, I began taking this supplement. My stomach felt soothed immediately, and my arthritis pain vanished. I can hardly believe the improvement in my arthritis and digestion. I have no plans to stop taking this supplement.
Cat Claw
8
In this study, we explored the effects of the herbal medicine Uncaria tomentosa, commonly known as cat's claw, particularly in treating arthritis. Cat's claw has long been valued for its anti-inflammatory properties, but we aimed to assess its broader pharmacological potential, especially regarding cytotoxicity and mutagenicity.
Our approach involved administering aqueous extracts of cat's claw to Wistar rats and observing its impact on bone marrow cells. Over the course of either 24 hours or 7 days, we evaluated whether the extract posed any harmful effects. Remarkably, we found that cat's claw did not exhibit any signs of cytotoxicity or mutagenicity in our analyses.
Furthermore, we examined how cat's claw interacts with cyclophosphamide, a chemotherapeutic drug. Interestingly, when cat's claw extracts were given alongside or just before/after cyclophosphamide, they significantly reduced the chromosomal aberrations caused by the drug. This indicates that cat's claw could serve as a complementary treatment option, potentially improving overall quality of life for arthritis patients, especially those undergoing chemotherapy.
Overall, our findings support the safe use of this herbal remedy, which is accessible through the Brazilian Public Health System, for managing arthritis symptoms while enhancing the recovery experience during chemotherapy.
Our approach involved administering aqueous extracts of cat's claw to Wistar rats and observing its impact on bone marrow cells. Over the course of either 24 hours or 7 days, we evaluated whether the extract posed any harmful effects. Remarkably, we found that cat's claw did not exhibit any signs of cytotoxicity or mutagenicity in our analyses.
Furthermore, we examined how cat's claw interacts with cyclophosphamide, a chemotherapeutic drug. Interestingly, when cat's claw extracts were given alongside or just before/after cyclophosphamide, they significantly reduced the chromosomal aberrations caused by the drug. This indicates that cat's claw could serve as a complementary treatment option, potentially improving overall quality of life for arthritis patients, especially those undergoing chemotherapy.
Overall, our findings support the safe use of this herbal remedy, which is accessible through the Brazilian Public Health System, for managing arthritis symptoms while enhancing the recovery experience during chemotherapy.
9
Effective for inflammation
Most Useful Review
2 people found this helpful
I have used cat's claw for years to combat inflammation resulting from arthritis. It works well for me. This is my first purchase of this brand: the price was reasonable and delivery was prompt.
Flax Seed Supplements
9
Effective arthritis management
Most Useful Review
1 people found this helpful
I’ve used various brands of flax oil over the years, but Now Flax Oil veggie softgels are my favourite. They're convenient and come in a 1,000 mg size, which is perfect for managing my arthritis. I will never voluntarily stop using this supplement or brand.
9
Beneficial for health
Most Useful Review
Flaxseed oil is rich in Omega 3, which I use for my heart, arthritis, and cholesterol. I've experienced great benefits, even for memory, hair, and skin. The product is vegetarian, high quality, and reasonably priced. I highly recommend flax oil for those with arthritis.
Multivitamins
9
Effective pain relief
Most Useful Review
129 people found this helpful
Good day! I tried a plant extract supplement instead of my usual arthritis prevention protocol. I experienced positive results; after two weeks, the pain in my shoulder disappeared and didn't return for six months. I highly recommend this supplement based on my experience!
9
Supports joint health
Most Useful Review
94 people found this helpful
Complex N 7 is effective for bursitis, helping alleviate pain and swelling due to arthritis. After using this product, my discomfort and swelling improved significantly, allowing greater mobility in my joints. I will continue taking it regularly.
Rutin
9
Relieves leg pain
Most Useful Review
Great product at an excellent price! I use it to strengthen blood vessels and improve circulation while relieving arthritis symptoms. After using it for five days, my legs feel much better.
7.5
Supports inflammation reduction
Most Useful Review
Vitamin P is utilised in alternative medicine to enhance vitamin C effects, support circulation, act as an antioxidant, and treat arthritis and other inflammatory conditions.
Arnica Topicals
9
Effective for pain
Most Useful Review
Arnica Oil is very effective for arthritis pain and works well. I've also used it for bruises and other aches.
7.5
Relieves joint pain
Most Useful Review
I find that it better relieves the arthritis in my knees and hands, making me feel good overall.
Selenium
7.5
Relieves joint pain
Most Useful Review
Selenium and E are minerals and trace elements that can relieve joint pain in rheumatoid arthritis.
7.5
Improves joint mobility
Most Useful Review
I asked for selenium due to its numerous benefits. It aids in improving joint mobility and is recommended for rheumatoid arthritis. I'm optimistic it will help me, and I recommend it.
Spirulina
7.5
Effective for arthritis
Most Useful Review
I'm optimistic about its effect on arthritis. I take it because it is beneficial for knee arthritis, and I consume fatty meat along with it after meals.
7.5
Healing action noted
Most Useful Review
1 people found this helpful
Provides a beneficial effect on the gastrointestinal tract, functioning as a prebiotic and promoting healthy microflora. It assists in combating allergies and eases symptoms of allergic rhinitis by reducing cellular reactions to allergens. This product offers antioxidant protection through compounds that effectively neutralise oxidative damage from free radicals. Additionally, it aids in lowering cholesterol and blood pressure, alongside controlling diabetes. Its healing properties also extend to arthritis.
Nettle
9
Works effectively
Most Useful Review
9 people found this helpful
Now Foods Stinging Nettle Root Extract, 250 mg, works really well for arthritis.
7.5
Significant improvement
Most Useful Review
1 people found this helpful
I am Mommy Rebekah, aged 62. Last year, I suffered from degenerative arthritis in my right finger, causing stiffness and discomfort each morning. Since taking this product, I have experienced significant improvement.
Peppermint Oil
10
Effective for knee pain
Most Useful Review
I use it to massage my knee affected by arthritis, and it is very effective.
7.5
Calms arthritis pain
Most Useful Review
Love the scent. I use it in my humidifier to fragrance my home. Peppermint has a relaxing quality that soothes the senses. I appreciate the benefits it provides when added to lotion to ease my arthritis. Great price too.
Ginger Oil
10
Significant pain reduction
Most Useful Review
I had severe pain in my hands due to arthritis, feeling as if my fingers would break. After applying this ginger oil nightly before bed, I began to feel a difference within a week. After a month, most of the pain had vanished. I keep it by my bedside.
9
Regular pain relief
Most Useful Review
I use it regularly as it's effective for relieving arthritis pain.
Alpha Lipoic Acid
9
Pain relief noted
Most Useful Review
6 people found this helpful
I started taking this supplement about two months ago to assist with arthritis in my fingers and sciatica pain. I can't pinpoint when the pain subsided; one day I just realised, “wow, I haven’t had pain in a while!” ALA, combined with specific exercises for my sciatica, has provided me with considerable relief. The arthritis in my fingers is nearly gone.
7.5
Game changer experience
Most Useful Review
2 people found this helpful
This is my third bottle of Doctor's Best Alpha-Lipoic Acid. It has been transformative for managing my arthritis, especially in my fingers (being vegan has likely helped too). I highly recommend it for anyone with mild arthritis.
Barley Grass
7.5
Extended arthritis relief
Most Useful Review
1 people found this helpful
Green Magma is a vital part of my daily routine. My grandmother claims it reversed her rheumatoid arthritis when she began taking two doses a day 30 years ago, with symptoms eventually fading. Although the arthritis resurfaced after 30 years, if she's right, it granted her those extra years. I started using it after learning from her and another healthy family member. I consume it every morning before my workout, and I believe it contributes to my overall energy and wellness throughout the day. We certainly need more greens in our diet! I appreciate that Green Magma is derived from a single plant, unlike some brands that mix many herbs, making digestion easier and tastier.
7.5
Improved arthritis control
Most Useful Review
I can't go a day without Green Magma. It energises me and helps manage my rheumatoid arthritis. I truly notice the difference when I skip it.
Alfalfa
10
Wonders for arthritis
Most Useful Review
1 people found this helpful
I have been taking alfalfa for over 30 years, and it has done wonders for my arthritis.
9
Helps with arthritis
Most Useful Review
1 people found this helpful
I purchased this for my 90-year-old mother-in-law, who knits all the time, and it assists her with arthritis in her hands. She swears by it.
Childrens Herbs
7.5
Inflammation reduction
Most Useful Review
Preparations containing echinacea help reduce systemic inflammation in arthritis. Its anti-inflammatory and immunomodulatory effects are beneficial against respiratory diseases, including asthma.
7.5
Anti-inflammatory benefits
Most Useful Review
Echinacea preparations reduce systemic inflammation in arthritis, while its anti-inflammatory properties aid in combating respiratory conditions.
Fiber
7.5
Pain relief achieved
Most Useful Review
533 people found this helpful
It helps with arthritis! Animal Flex is a substantial can containing 44 sachets, each with 8 tablets and capsules. I ordered it for my mother, aged 64, who suffers from knee, lower back, and shoulder pain. After trying various pills and hospital treatments, nothing worked until we tried Animal Flex. Initially sceptical, my mother soon found relief after a few weeks, experiencing less pain and improved sleep without the need for painkillers. Though after some time, we did have to resume pain medication, this product shows success in severe cases, especially for arthritis sufferers.
9
Effective anti-inflammatory
Most Useful Review
246 people found this helpful
I chose to buy this specific phytosomal curcumin, Meriva, which is a patented formula combined with lecithin phospholipids. This formula addresses curcumin's main issue – its bioavailability – and ensures a consistent release. Studies have shown Meriva to be 29 times more digestible than regular curcumin powder. It significantly benefits arthritis sufferers, particularly in managing rheumatoid arthritis and osteoarthritis. I hope this review proves useful; I am thankful for others' feedback as it has guided my choices.
Resveratrol
NOW Foods Resveratrol
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 13 Reviews
8
9
Reduces arthritis symptoms
Most Useful Review
7 people found this helpful
Resveratrol is a powerful natural antioxidant that supports heart health and combats conditions like coronary heart disease and arteriosclerosis. It also lowers cholesterol, alleviates arthritis, and has anti-aging properties for the skin. Now Foods offers convenient 200 mg capsules, which can be taken throughout the day for those requiring higher doses. I highly recommend this product!
7.5
Supports arthritis treatment
Most Useful Review
3 people found this helpful
This powerful antioxidant from grape seeds is suitable for those favouring natural remedies. Resveratrol may lower blood pressure, which is pertinent for those with low pressure. Weight loss requires a calorie deficit, but this supplement also slows cognitive decline and could enhance insulin sensitivity while easing arthritis pain. Thus, older individuals may benefit significantly.
Topical Ointments
7.5
Effective pain relief
Most Useful Review
11 people found this helpful
I find this product very effective for my arthritis. I struggled to sleep due to pain, but this cream alleviates it enough for a good night's rest. Although it doesn't last long, the relief it provides allows me to feel better until morning. While the smell isn't pleasant, the benefits outweigh this, and I will continue using it.
10
Magical results
Most Useful Review
10 people found this helpful
This cream worked wonders for my rheumatoid arthritis. After using it only twice, I experienced remarkable relief in my swollen elbows. I’m incredibly grateful for this product and its effectiveness.