Enzymes
8
CoQ10 shows promise for arthritis
Coenzyme Q10 supplementation in rheumatic diseases: A systematic review.
Most Relevant Research
Examining how Coenzyme Q10 (CoQ10) affects arthritis is crucial given its potential as a treatment option. We reviewed twenty articles published between 1966 and April 2023, encompassing a total of 483 participants. The focus was primarily on Rheumatoid Arthritis (RA), alongside Fibromyalgia (FM) and Antiphospholipid Syndrome (APS).
Our findings indicate that CoQ10 supplementation has shown promising results for RA patients. Improvements were observed in key areas such as disease activity, inflammatory markers, and even cytokine levels, marking a positive shift in health. Additionally, fibromyalgia patients reported better management of pain, fatigue, and sleep quality, along with enhanced mood and tender point counts. This suggests a broader application of CoQ10 beyond just arthritis.
We also noted that CoQ10 was generally well tolerated among patients, with only minimal side effects reported. Therefore, incorporating CoQ10 might serve as an effective complementary therapy for those dealing with RA and FM. Future studies with larger sample sizes and diverse rheumatic conditions would be beneficial to further validate these findings.
Our findings indicate that CoQ10 supplementation has shown promising results for RA patients. Improvements were observed in key areas such as disease activity, inflammatory markers, and even cytokine levels, marking a positive shift in health. Additionally, fibromyalgia patients reported better management of pain, fatigue, and sleep quality, along with enhanced mood and tender point counts. This suggests a broader application of CoQ10 beyond just arthritis.
We also noted that CoQ10 was generally well tolerated among patients, with only minimal side effects reported. Therefore, incorporating CoQ10 might serve as an effective complementary therapy for those dealing with RA and FM. Future studies with larger sample sizes and diverse rheumatic conditions would be beneficial to further validate these findings.
9.5
Improves mobility
Most Useful Review
I included enzyme therapy in my book on chronic illness. Serrapeptase, a powerful anti-inflammatory, has noticeably improved my knee joint mobility and reduced chronic inflammation after six weeks. I appreciate the potency and value of this product, which has proven effective against issues like arthritis.
Turmeric Rhizome
9.5
Pain relief
Most Useful Review
I began using turmeric extract years ago for my arthritis pain in my hips. The pain has vanished, and I continue to take it for maintenance. It also boosts my immune system and keeps me well. Each evening, I consume one eye dropper of the turmeric extract in a cup with honey and non-dairy milk. It helps me achieve a peaceful sleep.
9.5
Effective for hands
Most Useful Review
מצוין! It really helps with my arthritis in my hands and is easy to use in a hot beverage.
9.5
Joint pain relief
Most Useful Review
I buy this Omega-3 for my mother, who suffers from arthritis. Since she began taking it in winter, her joint and muscle pain has significantly improved.
9.5
Supports joint health
Most Useful Review
Omega-3s aid in supporting joint health and alleviating arthritis symptoms, which is crucial for me. They relieve inflammation and help preventosteoporosis.
Multivitamins
9.5
Joint pain relief
Most Useful Review
💯 RECOMMEND! These are the best vitamins for my joints. After suffering from knee pain, I tried various treatments, but nothing worked until an athlete recommended Animal Flex. Following the suggested regimen, my knee pain vanished. Doctors labelled it as arthritis, yet after two years of taking this supplement, they declared I am fine now. I recommend it highly—this regimen is effective for us!
9.5
Restored joint function
Most Useful Review
Animal Flex has been my go-to since 2011 for joint restoration. For optimal results, I suggest a longer intake of at least two months and regular dosing—as continuation benefits are seen. I've noted that glucosamine and chondroitin are essential in maintaining joint health, along with proper hydration and a healthy weight. It’s amazing to experience the improvement in my joints after weeks of usage!
Flax Seed Oil
9.5
Effective arthritis management
Most Useful Review
I’ve used various brands of flax oil over the years, but Now Flax Oil veggie softgels are my favourite. They're convenient and come in a 1,000 mg size, which is perfect for managing my arthritis. I will never voluntarily stop using this supplement or brand.
9.5
Beneficial for health
Most Useful Review
Flaxseed oil is rich in Omega 3, which I use for my heart, arthritis, and cholesterol. I've experienced great benefits, even for memory, hair, and skin. The product is vegetarian, high quality, and reasonably priced. I highly recommend flax oil for those with arthritis.
Polygonum Cuspidatum Complex
9.5
Reduces arthritis symptoms
Most Useful Review
Resveratrol is a powerful natural antioxidant that supports heart health and combats conditions like coronary heart disease and arteriosclerosis. It also lowers cholesterol, alleviates arthritis, and has anti-aging properties for the skin. Now Foods offers convenient 200 mg capsules, which can be taken throughout the day for those requiring higher doses. I highly recommend this product!
7.5
Supports arthritis treatment
Most Useful Review
This powerful antioxidant from grape seeds is suitable for those favouring natural remedies. Resveratrol may lower blood pressure, which is pertinent for those with low pressure. Weight loss requires a calorie deficit, but this supplement also slows cognitive decline and could enhance insulin sensitivity while easing arthritis pain. Thus, older individuals may benefit significantly.
Evening Primrose
9.5
Manages arthritis symptoms
Most Useful Review
Primula oil regulates hormones and helps with various ailments, including arthritis and menstrual disorders. It has a positive effect on high blood pressure and is effective against eczema and diabetes. I took it to restore my cycle and was pleased with the results. My skin did become quite oily, so I will try another course in winter.
9.5
Relieves arthritis pain
Most Useful Review
The Evening Primrose Oil from NOW is effective for reducing arthritis pain.
Chondroitin Sulfate Sodium
7
MSM shows limited arthritis benefits
The effect of MSM in the treatment of ankle arthrosis: Is MSM as effective as methylprednisolone or hyaluronic acid?
Most Relevant Research
We explored how methylsulfonylmethane (MSM) compares to other treatments like methylprednisolone and hyaluronic acid in addressing ankle arthritis that stems from trauma, known as posttraumatic ankle osteoarthritis (PTAO). In our study, we monitored how 32 adult rats responded to different treatment methods over eight weeks. We divided them into four groups: one received MSM orally, while the others received injections of methylprednisolone or hyaluronic acid. The fourth group served as a control.
Our findings showed that both the methylprednisolone and MSM groups had better radiological results compared to the control group, indicating some effectiveness. However, when we assessed the severity of arthritis, the methylprednisolone group performed notably better than the hyaluronic acid group. Interestingly, we found no significant differences between the MSM and control groups in terms of histopathological changes, which raises questions about the efficacy of MSM on its own.
Additionally, there was no notable change in the range of motion among the groups, suggesting that while both MSM and methylprednisolone may slow the progression of arthritis, MSM might not offer substantial benefits compared to current treatment standards. This makes it clear that an honest review of treatment options in daily practice is needed.
Our findings showed that both the methylprednisolone and MSM groups had better radiological results compared to the control group, indicating some effectiveness. However, when we assessed the severity of arthritis, the methylprednisolone group performed notably better than the hyaluronic acid group. Interestingly, we found no significant differences between the MSM and control groups in terms of histopathological changes, which raises questions about the efficacy of MSM on its own.
Additionally, there was no notable change in the range of motion among the groups, suggesting that while both MSM and methylprednisolone may slow the progression of arthritis, MSM might not offer substantial benefits compared to current treatment standards. This makes it clear that an honest review of treatment options in daily practice is needed.
9.5
Knee pain relief
Most Useful Review
Mum had severe knee joint pain when walking, and after a month of taking chondroprotectors, the pain disappeared. I ordered different brands, and this one from NOW seemed most effective. For added efficiency, I also got Boswellia extract, which I highly recommend.
Protein
8
Comparative effectiveness of IL-6 inhibitors
Comparative effectiveness of subcutaneous sarilumab 200 mg biweekly, subcutaneous Tocilizumab 162 mg biweekly, and intravenous Tocilizumab 8 mg/kg every 4 weeks in patients with rheumatoid arthritis: a prospective cohort study.
Most Relevant Research
We aimed to explore the effectiveness of three different medications that target the interleukin-6 receptor (IL-6R) in treating rheumatoid arthritis (RA). These medications include subcutaneous sarilumab (SAR-SC), subcutaneous tocilizumab (TCZ-SC), and intravenous tocilizumab (TCZ-IV). Our study was designed as a multicenter cohort study, gathering data from patients in Japan over several years, focusing specifically on those who hadn’t previously received IL-6R inhibitors.
After treating patients for 24 weeks, we found that those taking SAR-SC experienced a statistically significant reduction in disease activity compared to those on TCZ-SC. This is exciting news for people with RA, as it suggests that SAR-SC could potentially offer better outcomes for initial treatment. However, when comparing TCZ-IV and TCZ-SC, we did not observe significant differences in effectiveness.
The findings underscore the importance of considering both the effectiveness and cost of treatment options. While SAR-SC seemed more effective, the pricing of medications, including TCZ-SC and its biosimilars, should be factored into treatment decisions. Overall, our research contributes valuable insights into how these protein treatments can influence the management of arthritis.
After treating patients for 24 weeks, we found that those taking SAR-SC experienced a statistically significant reduction in disease activity compared to those on TCZ-SC. This is exciting news for people with RA, as it suggests that SAR-SC could potentially offer better outcomes for initial treatment. However, when comparing TCZ-IV and TCZ-SC, we did not observe significant differences in effectiveness.
The findings underscore the importance of considering both the effectiveness and cost of treatment options. While SAR-SC seemed more effective, the pricing of medications, including TCZ-SC and its biosimilars, should be factored into treatment decisions. Overall, our research contributes valuable insights into how these protein treatments can influence the management of arthritis.
9.5
Beneficial for arthritis
Most Useful Review
The quality is excellent. I have repurchased pumpkin seeds numerous times due to their anti-inflammatory effects, which benefit my periodontal disease and arthritis. They are natural and healthy, making them a long-time staple in my diet.
Vitamins
8
Vitamin D shows promise for RA
Effects of vitamin D supplementation in patients with rheumatoid arthritis: A systematic review and meta-analysis.
Most Relevant Research
We explored the effects of vitamin D supplementation on adults with rheumatoid arthritis (RA), an inflammatory condition affecting millions worldwide. By examining clinical studies that compared vitamin D to either a placebo or standard care, we focused on how these supplements might influence various health outcomes for those suffering from RA.
Our analysis included 11 studies, highlighting several noteworthy findings. We observed a significant improvement in key measures: the Disease Activity Score 28 (DAS-28) showed a meaningful reduction, while levels of C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) also decreased. Furthermore, vitamin D supplementation led to an increase in serum vitamin D levels.
Despite these positive results, vitamin D supplementation did not appear to significantly impact the health assessment questionnaire (HAQ) and visual analog scale for pain (VAS-pain) scores. Consequently, while vitamin D can help reduce inflammation and improve specific health parameters in RA patients, the optimal dosage and duration of treatment remain unclear.
Overall, our findings suggest that boosting vitamin D levels might offer benefits for managing RA, and further research may help refine treatment strategies for optimal outcomes.
Our analysis included 11 studies, highlighting several noteworthy findings. We observed a significant improvement in key measures: the Disease Activity Score 28 (DAS-28) showed a meaningful reduction, while levels of C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) also decreased. Furthermore, vitamin D supplementation led to an increase in serum vitamin D levels.
Despite these positive results, vitamin D supplementation did not appear to significantly impact the health assessment questionnaire (HAQ) and visual analog scale for pain (VAS-pain) scores. Consequently, while vitamin D can help reduce inflammation and improve specific health parameters in RA patients, the optimal dosage and duration of treatment remain unclear.
Overall, our findings suggest that boosting vitamin D levels might offer benefits for managing RA, and further research may help refine treatment strategies for optimal outcomes.
10
Resolved health issues
Most Useful Review
This vitamin is the best supplement! I was prescribed it for depression, and after a month, I noticed a significant difference. I feel more energetic. My partner suffered from stomach issues and arthritis, but after taking this supplement, he overcame these problems and saw further improvements.
Tumeric
9
CUR-PDT shows promise in RA therapy
CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis.
Most Relevant Research
We delved into the effects of curcumin, particularly through a method called photodynamic therapy (CUR-PDT), in the context of rheumatoid arthritis. The research focused on how this treatment might trigger a specific type of cell death known as ferroptosis in fibroblast-like synoviocytes (FLSs), which are key players in arthritis inflammation.
Our study incorporated both in vivo and in vitro methods. In the animal model, we observed that CUR-PDT helped reduce joint swelling and associated inflammation. We also looked closely at how this treatment affected specific markers within FLSs, particularly focusing on the Nrf2/xCT/GPX4 signaling pathway. This pathway is crucial because it helps regulate responses to oxidative stress—something that can be detrimental in arthritis.
Through various tests, including measuring cell viability and cell responses to oxidative stress, we found that CUR-PDT effectively induced ferroptosis in the FLSs. This led to decreased cell proliferation and therefore suggests a potential avenue for treating rheumatoid arthritis more effectively. Although our findings show promising results regarding curcumin's role, it is important to emphasize that these effects stemmed more from the method of photodynamic therapy than solely from curcumin itself.
Overall, this research shines a light on the importance of understanding how curcumin, when utilized in specific therapeutic approaches, may contribute to better managing rheumatoid arthritis. However, the exact applications and benefits still require further exploration.
Our study incorporated both in vivo and in vitro methods. In the animal model, we observed that CUR-PDT helped reduce joint swelling and associated inflammation. We also looked closely at how this treatment affected specific markers within FLSs, particularly focusing on the Nrf2/xCT/GPX4 signaling pathway. This pathway is crucial because it helps regulate responses to oxidative stress—something that can be detrimental in arthritis.
Through various tests, including measuring cell viability and cell responses to oxidative stress, we found that CUR-PDT effectively induced ferroptosis in the FLSs. This led to decreased cell proliferation and therefore suggests a potential avenue for treating rheumatoid arthritis more effectively. Although our findings show promising results regarding curcumin's role, it is important to emphasize that these effects stemmed more from the method of photodynamic therapy than solely from curcumin itself.
Overall, this research shines a light on the importance of understanding how curcumin, when utilized in specific therapeutic approaches, may contribute to better managing rheumatoid arthritis. However, the exact applications and benefits still require further exploration.
9.5
Pain relief
Most Useful Review
Fantastic supplement for arthritis sufferers! I have rheumatoid arthritis in my wrists and knees. I've taken Jarrow and Now brands Curcumin for months, which has significantly reduced my pain and flare-ups. I recently tried the Bio form of Curcumin, and it felt miraculous. Post-taking, I experienced a surge in energy, but beware of overdoing it as I did. Thanks iHerb for the great prices and fresh supplements.
Magnesium
8
Magnesium benefits for osteoarthritis
Injectable Chondroitin Sulfate Microspheres with Gallic Acid-Magnesium MOF for Anti-Inflammatory and Cartilage Degeneration Alleviation in Osteoarthritis Treatment.
Most Relevant Research
Our exploration focused on how magnesium can aid in treating the challenges associated with osteoarthritis, such as inflammation and cartilage degeneration. We synthesized a special carrier made from a combination of gallic acid and magnesium, designed to deliver a drug called puerarin effectively. This innovative approach involved forming hybrid microspheres that can be injected into the joint space.
During our tests, we noted that these magnesium-infused microspheres not only helped to release the drug over a longer period— extending beyond two weeks but they also positively affected the joint environment by reducing inflammation and oxidative stress. This means that magnesium, when combined with other components, can support overall joint health and promote cartilage repair.
In our in vivo experiments, we saw significant reductions in osteophyte formation and noticeable improvements in cartilage conditions, leading to a delay in the progression of osteoarthritis. Overall, these findings suggest that this magnesium-based delivery system could be an exciting avenue for enhancing treatment options for those suffering from osteoarthritis.
During our tests, we noted that these magnesium-infused microspheres not only helped to release the drug over a longer period— extending beyond two weeks but they also positively affected the joint environment by reducing inflammation and oxidative stress. This means that magnesium, when combined with other components, can support overall joint health and promote cartilage repair.
In our in vivo experiments, we saw significant reductions in osteophyte formation and noticeable improvements in cartilage conditions, leading to a delay in the progression of osteoarthritis. Overall, these findings suggest that this magnesium-based delivery system could be an exciting avenue for enhancing treatment options for those suffering from osteoarthritis.
9.8
Effective pain relief
Most Useful Review
I recommend this supplement for arthritis in the knees. After enduring several surgeries and experiencing unbearable pain, I noticed an unbelievable difference just four days after starting this supplement. It provided me with significant relief, better than any painkiller I’ve tried, and restored my knee movement. I truly wish I’d discovered this 40 years ago.
Quercetin
8
Quercetin shows promise for RA
Effects of plant active substances in rheumatoid arthritis-a systematic review and network meta-analysis.
Most Relevant Research
We conducted a systematic review and network meta-analysis to assess the effectiveness of quercetin and other plant active substances for treating rheumatoid arthritis (RA). Our findings revealed that quercetin particularly stands out for its ability to reduce pain and inflammation, as measured by the Visual Analogue Scale (VAS).
In our analysis, quercetin was shown to be effective in alleviating symptoms, making it a potentially valuable option for individuals suffering from RA. However, while we observed these positive effects, it's important to note that quercetin's benefits are often considered alongside other treatments, making it difficult to isolate its specific impact.
Overall, our research highlights the promise of quercetin in managing rheumatoid arthritis, but we also stress the need for additional studies to further confirm and clarify these effects. We believe that this information can help patients and healthcare providers make more informed decisions about using plant-based therapies in RA treatment.
In our analysis, quercetin was shown to be effective in alleviating symptoms, making it a potentially valuable option for individuals suffering from RA. However, while we observed these positive effects, it's important to note that quercetin's benefits are often considered alongside other treatments, making it difficult to isolate its specific impact.
Overall, our research highlights the promise of quercetin in managing rheumatoid arthritis, but we also stress the need for additional studies to further confirm and clarify these effects. We believe that this information can help patients and healthcare providers make more informed decisions about using plant-based therapies in RA treatment.
9.5
Significant relief
Most Useful Review
Quercetin and bromelain are potent natural ingredients that alleviate allergic and inflammatory disorders, including arthritis. They help mitigate asthma, eczema, and other conditions. As someone suffering from arthritis, Raynaud's syndrome, and various allergies, I find Quercetin a real lifesaver. I take it regularly and wholeheartedly recommend it!
MSM
7
MSM shows limited arthritis benefits
The effect of MSM in the treatment of ankle arthrosis: Is MSM as effective as methylprednisolone or hyaluronic acid?
Most Relevant Research
We explored how methylsulfonylmethane (MSM) compares to other treatments like methylprednisolone and hyaluronic acid in addressing ankle arthritis that stems from trauma, known as posttraumatic ankle osteoarthritis (PTAO). In our study, we monitored how 32 adult rats responded to different treatment methods over eight weeks. We divided them into four groups: one received MSM orally, while the others received injections of methylprednisolone or hyaluronic acid. The fourth group served as a control.
Our findings showed that both the methylprednisolone and MSM groups had better radiological results compared to the control group, indicating some effectiveness. However, when we assessed the severity of arthritis, the methylprednisolone group performed notably better than the hyaluronic acid group. Interestingly, we found no significant differences between the MSM and control groups in terms of histopathological changes, which raises questions about the efficacy of MSM on its own.
Additionally, there was no notable change in the range of motion among the groups, suggesting that while both MSM and methylprednisolone may slow the progression of arthritis, MSM might not offer substantial benefits compared to current treatment standards. This makes it clear that an honest review of treatment options in daily practice is needed.
Our findings showed that both the methylprednisolone and MSM groups had better radiological results compared to the control group, indicating some effectiveness. However, when we assessed the severity of arthritis, the methylprednisolone group performed notably better than the hyaluronic acid group. Interestingly, we found no significant differences between the MSM and control groups in terms of histopathological changes, which raises questions about the efficacy of MSM on its own.
Additionally, there was no notable change in the range of motion among the groups, suggesting that while both MSM and methylprednisolone may slow the progression of arthritis, MSM might not offer substantial benefits compared to current treatment standards. This makes it clear that an honest review of treatment options in daily practice is needed.
8.8
Reduces joint pain
Most Useful Review
Very good additive! MSM is an organic sulphur compound with anti-inflammatory effects. I purchased it for my mother, who suffers from arthritis, and she has experienced some relief in her joint pain and sinus issues. I also tried it for my allergies, and it has significantly reduced my morning cough and improved my breathing. I even found relief from severe bloating that previous medications couldn't alleviate.
Zinc
9
Zinc nanoparticles aid gout treatment
A novel zinc ferrite nanoparticle protects against MSU-induced gout arthritis via Nrf2/NF-κB/NLRP3 pathway.
Most Relevant Research
We explored the potential benefits of a new treatment involving zinc ferrite nanoparticles (ZFN) for individuals suffering from gouty arthritis (GA). This form of arthritis can be painful and complex, affecting people of all ages. Traditional treatments often come with side effects, prompting a search for more effective and safer alternatives.
The study revealed that zinc ferrite nanoparticles have impressive anti-inflammatory and antioxidant properties, which can help in managing the symptoms of gouty arthritis. Through a combination of laboratory and animal studies, we observed that ZFN significantly reduced inflammation and oxidative stress. Interestingly, it appears to work by modifying critical pathways involved in inflammation, specifically by influencing the NF-κB pathway and the NLRP3 inflammasome, while also activating the Nrf2 pathway.
These findings suggest that ZFN could become a promising option for treating gouty arthritis, providing an innovative and biocompatible approach to therapy. By addressing inflammation at its source, zinc ferrite nanoparticles could offer a new ray of hope for those dealing with GA, showcasing the potential for nanotechnology in improving health outcomes.
The study revealed that zinc ferrite nanoparticles have impressive anti-inflammatory and antioxidant properties, which can help in managing the symptoms of gouty arthritis. Through a combination of laboratory and animal studies, we observed that ZFN significantly reduced inflammation and oxidative stress. Interestingly, it appears to work by modifying critical pathways involved in inflammation, specifically by influencing the NF-κB pathway and the NLRP3 inflammasome, while also activating the Nrf2 pathway.
These findings suggest that ZFN could become a promising option for treating gouty arthritis, providing an innovative and biocompatible approach to therapy. By addressing inflammation at its source, zinc ferrite nanoparticles could offer a new ray of hope for those dealing with GA, showcasing the potential for nanotechnology in improving health outcomes.
9.5
Improved sleep
Most Useful Review
I purchased these vitamins to strengthen my immune system and support my joints, as I suffer from arthritis. I have recently started taking them and have noticed no negative effects. My sleep has improved, and there’s new hair growth in bald patches. Overall, I’m pleased with the vitamins and would recommend them for arthritis.
Hyaluronic Acid
9
Hyaluronic acid's long-term effects unclear
Long-term effectiveness of intra-articular injectables in patients with knee osteoarthritis: a systematic review and Bayesian network meta-analysis.
Most Relevant Research
We dug into the effectiveness of hyaluronic acid (HA) as a treatment for knee osteoarthritis (OA). By examining data from 37 randomized controlled trials involving over 5,000 patients, we aimed to understand how well HA works in providing pain relief and improving knee function over the long term.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
9.5
Effective for arthritis
Most Useful Review
A worthy competitor to medicinal chondroprotectors! The order arrived in 4 days, well packed, with the product matching the description and expiry date. The capsules are medium-sized, easy to take, and have a yeasty smell. I find this medication beneficial for my arthritis; the crunch in my knee joint disappears, and any discomfort subsides during exertion. My skin feels more hydrated, and fine wrinkles are less apparent. The convenient dosage of 100mg, when combined with adequate hydration and vitamin C, proves effective.
Gelatin
8.3
Joint relief
Most Useful Review
Gelatin is crucial for healthy hair, skin, and cartilage. It contains amino acids that are well absorbed, nourishing joints and relieving arthritis pain, while also improving mobility.
9.5
Improves joint condition
Most Useful Review
Gelatin significantly enhances my bone and joint health. I initially took it with collagen but found that gelatin alone worked wonders for my arthritis. Following the dosage instructions, I have noticed an improvement in my condition and joint mobility, making it a worthwhile and budget-friendly supplement.
Collagen
9
Hyaluronic acid's long-term effects unclear
Long-term effectiveness of intra-articular injectables in patients with knee osteoarthritis: a systematic review and Bayesian network meta-analysis.
Most Relevant Research
We dug into the effectiveness of hyaluronic acid (HA) as a treatment for knee osteoarthritis (OA). By examining data from 37 randomized controlled trials involving over 5,000 patients, we aimed to understand how well HA works in providing pain relief and improving knee function over the long term.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
Our findings show that while hyaluronic acid has its benefits, especially when combined with other treatments like platelet-rich plasma (PRP), its standalone effectiveness for long-term management isn't as clear. Patients who received HA combined with PRP experienced better outcomes, but isolating HA’s effects still leaves some questions.
Overall, our exploration highlighted the potential of HA in knee OA treatment, particularly when used in conjunction with other injectables. However, if you're considering HA as a solo treatment, the evidence suggests that more research is needed to fully determine how effective it is on its own.
10
Eliminates arthritis pain
Most Useful Review
Unbelievable! After using this for 30 days, the pain in my hands from arthritis vanished, and I regained 100% use of them. Great stuff!
N Acetylglucosamine
8
Glucosamine derivatives aid cartilage health
The Hexosamine Biosynthetic Pathway as a Therapeutic Target after Cartilage Trauma: Modification of Chondrocyte Survival and Metabolism by Glucosamine Derivatives and PUGNAc in an Ex Vivo Model.
Most Relevant Research
We examined how glucosamine derivatives, particularly n-acetylglucosamine (GlcNAc), impact chondrocyte behavior following cartilage trauma. In our study, human cartilage samples were subjected to trauma and then treated with GlcNAc, glucosamine sulfate, or an O-GlcNAcase inhibitor called PUGNAc, alongside a GFAT-1 inhibitor named azaserine. Over the course of the experiment, we looked at factors such as cell viability, the expression of key genes related to cartilage health, and the content of important cartilage components like type II collagen.
Our findings revealed that exposing cartilage to trauma disrupted the balance of enzymes involved in the hexosamine biosynthetic pathway (HBP), mimicking the conditions seen in advanced osteoarthritis. Both GlcNAc and PUGNAc showed encouraging results by protecting cells after trauma. However, while PUGNAc led to an increase in type II collagen production, GlcNAc did not demonstrate this same enhancement, indicating that it may not be as effective on its own.
Importantly, PUGNAc, along with the glucosamine derivatives, demonstrated anti-catabolic effects, helping counteract degrading processes in the cartilage. Conversely, the use of azaserine raised catabolic activity, which wasn't beneficial. Overall, we found that supporting the HBP through glucosamine derivatives or O-GlcNAcase inhibition can help protect cartilage cells following trauma, presenting a promising area for future arthritis therapies despite the variable effects of GlcNAc alone.
Our findings revealed that exposing cartilage to trauma disrupted the balance of enzymes involved in the hexosamine biosynthetic pathway (HBP), mimicking the conditions seen in advanced osteoarthritis. Both GlcNAc and PUGNAc showed encouraging results by protecting cells after trauma. However, while PUGNAc led to an increase in type II collagen production, GlcNAc did not demonstrate this same enhancement, indicating that it may not be as effective on its own.
Importantly, PUGNAc, along with the glucosamine derivatives, demonstrated anti-catabolic effects, helping counteract degrading processes in the cartilage. Conversely, the use of azaserine raised catabolic activity, which wasn't beneficial. Overall, we found that supporting the HBP through glucosamine derivatives or O-GlcNAcase inhibition can help protect cartilage cells following trauma, presenting a promising area for future arthritis therapies despite the variable effects of GlcNAc alone.
9.5
Pain relief
Most Useful Review
I discovered this supplement by chance on the iHerb website. I suffer from various food allergies, digestive issues, and arthritis. After a difficult weekend with an upset stomach and aching arthritis, I began taking this supplement. My stomach felt soothed immediately, and my arthritis pain vanished. I can hardly believe the improvement in my arthritis and digestion. I have no plans to stop taking this supplement.
Omega 3
8
Eicosapentaenoic acid aids arthritis
Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Most Relevant Research
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
9.5
Joint health
Most Useful Review
Fish oil is beneficial for the brain and boosts the immune system. It lowers blood pressure and improves joint mobility, which is vital for those suffering from arthritis. My therapist recommended it to stabilise my cholesterol. This is a high-quality product at a reasonable price. Our family takes it daily, and we notice no side effects. Highly recommended for everyone!
Fish Oil
8
Eicosapentaenoic acid aids arthritis
Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Most Relevant Research
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
9.5
Improves arthritis mobility
Most Useful Review
Excellent for arthritis! I have advanced post-traumatic arthritis in my ankle, and Now Foods Omega-3 has helped eliminate pain and improve mobility. Highly recommended!
Wild Caught Fish Oil
8
Eicosapentaenoic acid aids arthritis
Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Most Relevant Research
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.
Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.
Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
8.8
Pain relief
Most Useful Review
Despite the high price, I find this omega-3 to be the best available in terms of quality and ingredients. It effectively alleviates my arthritis pain when combined with vitamin D and curcumin, and even enhances my focus, which I had been losing due to my condition.
Elderberry
7
Elderberry shows promise for arthritis
Efficacy and short-term safety of topical Dwarf Elder (Sambucus ebulus L.) versus diclofenac for knee osteoarthritis: A randomized, double-blind, active-controlled trial.
Most Relevant Research
We explored the effectiveness of Dwarf Elder, or Sambucus ebulus, in treating knee osteoarthritis (OA) by conducting a randomized, double-blind clinical trial. In this study, we compared topical S. ebulus gel to a 1% diclofenac gel, known for its anti-inflammatory properties. Seventy-nine patients participated, applying the treatment three times a day for four weeks.
Throughout the trial, we measured changes in knee pain using a visual analogue scale and assessed functional improvements with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire.
Our findings suggest that topical S. ebulus gel might effectively ease knee OA symptoms. However, we noted that further research with larger groups is essential to confirm the long-term efficacy and safety of this natural remedy. Overall, while the initial results are promising, more extensive trials will provide a clearer perspective on the true potential of elderberry in managing knee osteoarthritis.
Throughout the trial, we measured changes in knee pain using a visual analogue scale and assessed functional improvements with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire.
Our findings suggest that topical S. ebulus gel might effectively ease knee OA symptoms. However, we noted that further research with larger groups is essential to confirm the long-term efficacy and safety of this natural remedy. Overall, while the initial results are promising, more extensive trials will provide a clearer perspective on the true potential of elderberry in managing knee osteoarthritis.
8.8
Immunity boost
Most Useful Review
Elderberry helps improve immunity and is beneficial for colds and arthritis. I take 2 capsules with vitamin C and D, and echinacea to recover quickly. During a mild illness, elderberry proved invaluable. I believe it’s essential to have elderberry at home as a remedy for colds. I highly recommend it!