Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 59 Researches
7.5
USERS' SCORE
Good
Based on 336 Reviews
8.3
Supplement Facts
Serving Size:  1 Capsule
Amount Per Serving
%DV
Proprietary Blend Containing 1 billion live cultures† Lactobacillus acidophilus Lactobacillus salivarius Bifidobacterium bifidum Streptococcus thermophilus
175 mg
**

Top Medical Research Studies

9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.

The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
Read More
9
Li01 shows promise for constipation relief
We explored the effects of Ligilactobacillus salivarius Li01 in a mouse model of constipation induced by loperamide. The findings show that Li01 can significantly improve symptoms of constipation by enhancing fecal water content and quantity, as well as promoting gut motility.

Additionally, Li01 seems to protect intestinal barrier structures and influence gut microbiota composition. By impacting the 5-HT signaling pathway, Li01 holds promise as a potential treatment for constipation. However, further research is necessary to fully understand its effects and applications.
Read More
9
Bifidobacterium’s health benefits in constipation
We explored the potential of various Bifidobacterium strains to alleviate constipation in mice caused by loperamide hydrochloride. Throughout 17 days of treatment, we administered six different strains and assessed their effects on gastrointestinal health.

Notably, only one strain showed significant benefits in improving stool consistency and enhancing gut function. This strain not only helped restore bile and fatty acid levels but also positively altered the gut microbiota of constipated mice. Our findings indicate that Bifidobacterium can be effective in managing constipation through its unique physiological capabilities.
Read More

Most Useful Reviews

10
Effective treatment
Excellent! I’ve suffered from constipation for over 15 years, leading to haemorrhoids. This product modifies bacteria in my digestive system and has resolved my constipation! It also removes toxins and is best taken before bed. It has been a remarkable addition to my routine and significantly improved my digestive health.
Read More
9.5
Daily bowel movements
This probiotic has been a miracle for my 7-year-old daughter, who has suffered from severe constipation since birth. After trying various treatments with no success, I tried probiotics and mixed capsules into kefir overnight. We now have daily bowel movements! I even tested it on my grandmother with similar success. This product has truly changed our lives.
Read More
9.5
Constipation resolved
Good probiotics! The quality is excellent, and they effectively normalised my intestinal work and improved digestion. I recommend them for anyone suffering from constipation.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 59 Researches
7.5
  • All Researches
9.5
Cultured milk drink relieves constipation
We explored the impact of a cultured milk drink containing Lactobacillus acidophilus on constipation symptoms in adults with constipation-predominant irritable bowel syndrome (IBS-C). Over 30 days, 77 participants drank this yogurt-like beverage daily.

Post-treatment, a staggering 97.4% of participants reported improvement in their symptoms, including decreased intestinal transit time and lower fecal pH. Notably, the levels of inflammatory cytokines also dropped significantly, suggesting potential benefits of this treatment for IBS-C patients.
Read More
9.5
Lactobacillus improves IBS-C symptoms
We investigated how a cultured milk drink containing Lactobacillus acidophilus affects symptoms of constipation in individuals with irritable bowel syndrome (IBS-C). Over 30 days, participants consumed the drink daily.

At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
Read More
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.

The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
Read More
We evaluated how lactobacillus acidophilus, both alone and in a mix with other bacteria, might relieve constipation caused by loperamide in rats. Over 14 days, we noticed that the groups receiving probiotics had significantly heavier and wetter stools compared to control animals.

Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Read More
9
Li01 shows promise for constipation relief
We explored the effects of Ligilactobacillus salivarius Li01 in a mouse model of constipation induced by loperamide. The findings show that Li01 can significantly improve symptoms of constipation by enhancing fecal water content and quantity, as well as promoting gut motility.

Additionally, Li01 seems to protect intestinal barrier structures and influence gut microbiota composition. By impacting the 5-HT signaling pathway, Li01 holds promise as a potential treatment for constipation. However, further research is necessary to fully understand its effects and applications.
Read More

User Reviews

USERS' SCORE
Good
Based on 336 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
10
Effective treatment
Excellent! I’ve suffered from constipation for over 15 years, leading to haemorrhoids. This product modifies bacteria in my digestive system and has resolved my constipation! It also removes toxins and is best taken before bed. It has been a remarkable addition to my routine and significantly improved my digestive health.
Read More
9.5
Daily bowel movements
This probiotic has been a miracle for my 7-year-old daughter, who has suffered from severe constipation since birth. After trying various treatments with no success, I tried probiotics and mixed capsules into kefir overnight. We now have daily bowel movements! I even tested it on my grandmother with similar success. This product has truly changed our lives.
Read More
9.5
Constipation resolved
Good probiotics! The quality is excellent, and they effectively normalised my intestinal work and improved digestion. I recommend them for anyone suffering from constipation.
Read More
9.5
Effective capsules
Excellent quality! The ingredients are good, with small capsules that are easy to take. I experienced a significant improvement in constipation, and my intestines now function properly.
Read More
10
Eczema relief
These capsules are the best I have tried! After suffering from constipation and eczema, these helped me go to the toilet gently after a few days. The eczema has improved too. I also started giving them to my child, and their chair has improved. I highly recommend this product for boosting immunity.
Read More

Frequently Asked Questions

Constipation is a common condition characterized by infrequent bowel movements or difficulty passing stools. It is typically defined as having fewer than three bowel movements per week, leading to hard, dry stools that are painful or difficult to expel. This condition can be caused by a variety of factors, including diet, dehydration, lack of physical activity, and certain medications. Stress and lifestyle changes can also contribute, making it essential for individuals to identify the root causes of their constipation for effective relief.

To alleviate constipation, it’s recommended to increase fiber intake by consuming more fruits, vegetables, whole grains, and legumes, as well as ensuring adequate hydration throughout the day. Regular exercise can also promote healthy bowel function. If over-the-counter solutions such as fiber supplements or laxatives aren't effective, it's advisable to consult a healthcare provider, as chronic constipation can lead to complications and indicate underlying health issues. Keeping a consistent eating and bathroom schedule can also help regulate bowel movements.

Acidophilus, scientifically known as Lactobacillus acidophilus, is a type of beneficial bacteria that is commonly found in the human gut, as well as in fermented foods like yogurt and dietary supplements. This probiotic strain plays a crucial role in maintaining gut health by aiding digestion, enhancing nutrient absorption, and supporting the immune system. It is particularly known for its ability to break down lactose, making it easier for lactose-intolerant individuals to digest dairy products.

In addition to its digestive benefits, acidophilus has been studied for its potential to prevent or alleviate certain gastrointestinal issues, such as diarrhea and irritable bowel syndrome (IBS). Some research also suggests that it may support vaginal health by helping to maintain a balanced microbiome in women. When selecting a probiotic supplement that contains acidophilus, it is essential to look for products that contain live and active cultures, ensuring that you receive the full benefits of this beneficial bacteria. Always consult with a healthcare professional before beginning any new supplement regimen.

While research on the effects of Acidophilus specifically for constipation is limited, some studies suggest that probiotics, including Lactobacillus acidophilus, may contribute to improved gut health and regularity. Probiotics like Acidophilus can help balance the gut flora, potentially alleviating some digestive issues that may lead to constipation. They may promote the growth of beneficial bacteria in the intestines, which can aid in the digestion process and enhance overall bowel function.

If you're considering incorporating Acidophilus into your diet to combat constipation, it's a good idea to do so alongside a balanced diet rich in fiber, hydration, and regular physical activity. While individual responses may vary, some people find that probiotics are a gentle way to promote digestive health. However, it's always best to consult with a healthcare professional before starting any new supplement, especially if you have persistent or severe constipation.

Based on user reviews, the timeframe for seeing improvements in constipation after starting this supplement can vary significantly but generally falls within a few days to a week. Many users report experiencing relief within this short period. For instance, one reviewer mentioned that improvements were noticeable within just two days of taking the probiotic at night, leading to significant betterment in their bowel movements (Read Review). Another user indicated they observed clear results after a week of use, noting regular bowel movements and a reduction in related symptoms like flatulence (Read Review).

Additionally, several reviewers expressed similar sentiments, with one stating that after a week of nightly use, their intestines began to function properly (Read Review). Overall, it appears that while individual experiences may vary, many users see noticeable improvements in their constipation issues within a few days to a week of using this probiotic.

Various studies have investigated the effectiveness of probiotics in improving symptoms of constipation, showcasing promising results. For instance, a study analyzing two probiotic formulations designed for functional constipation in adults found that participants experienced improved stool frequency and quality after 30 days of daily intake, though the differences between the formulations were not statistically significant [37]. Similarly, multistrain probiotics were able to increase stool frequency among elderly nursing home residents, although the improvements were more pronounced later in the study and weren't statistically significant when laxative use was taken into account [20]. These findings suggest that while not universally effective, there is supportive evidence indicating that certain probiotic formulations may offer benefits for individuals struggling with constipation.

Furthermore, specific strains of probiotics, such as Lactobacillus and Bifidobacterium, have been particularly highlighted for their potential in alleviating constipation symptoms. In a controlled trial involving patients with chronic constipation linked to various conditions, a symbiotic mixture including Lactobacillus acidophilus demonstrated significant symptom relief, showcasing the potential benefits that probiotics can offer in the management of constipation [11]. Overall, while results can vary based on the specific strains and conditions, there is a significant body of research suggesting that probiotics can indeed be a helpful option for those experiencing constipation.

Users of this probiotic have reported a variety of positive improvements in their constipation symptoms, with many noting significant relief after a few days of use. One long-term sufferer of constipation mentioned that their symptoms were resolved within just two days of taking the probiotic at night, leading to a remarkable improvement in their bowel movements (Read Review). Similarly, another reviewer experiencing chronic constipation for over 15 years observed a complete normalization of their digestion after a week, highlighting the product’s effectiveness(Read Review).

Several other users echoed these sentiments, with one parent noting that their child, who had suffered from severe constipation since birth, began experiencing daily bowel movements after incorporating the probiotic into their routine (Read Review). Another user reported an overall improvement in digestive health and reduced bloating while regularly taking the supplement (Read Review). While individual experiences can vary, these testimonials suggest that many users have found considerable relief and improvement in their digestive issues, making this probiotic a valuable addition to their health regimen.

Based on user reviews, many have reported positive experiences when combining this probiotic supplement with other supplements to manage constipation. One user noted that giving their elderly mother two capsules daily alongside triphala led to remarkable improvements in her digestive issues (Read Review). This combination appeared to enhance the efficacy of the probiotics, offering greater relief from constipation. In contrast, another user mentioned that alternating between different probiotic strains helped alleviate their irritable bowel syndrome symptoms, suggesting that mixing supplements could lead to better digestive health overall (Read Review).

Users have also discovered that incorporating the probiotic into other foods, like kefir, can enhance its effects. One parent shared that mixing the capsules into kefir for their child resulted in daily bowel movements, marking a significant turnaround after trying various treatments without success (Read Review). This implies that not only can this supplement work well independently, but it may also complement other dietary elements or supplements to further aid those struggling with constipation.

Based on user reviews, the recommended dosage of Acidophilus for treating constipation appears to vary. Some users have reported that taking one capsule before bed is effective in alleviating their constipation, noting significant improvements within a few days of starting the supplement (Read Review). Others found that taking two capsules daily provided even more benefits, particularly when combined with other digestive aids like triphala (Read Review).

Many reviewers emphasized consistency in their routine, suggesting that taking the capsules in the evening worked best for promoting healthy bowel movements and preventing digestive discomfort (Read Review). Additionally, users highlighted that the product’s effectiveness led to a notable change not just in their bowel health but also in their overall digestive comfort (Read Review). While individual results may vary, the general consensus leans toward staying within the one to two capsule range for optimal relief from constipation.

9.5
Effective remedy
I've faced ongoing constipation, and after just two days of taking this probiotic at night, my bowel movements have improved significantly. It was a pleasant surprise, and the capsules last a long time.
9.5
Clear improvement
The results are fantastic! After a week of use, I’ve seen clear improvements. I was struggling with severe constipation and this product helped me to have regular bowel movements. I’ve also noticed a reduction in flatulence. I purchased another box after finishing the first one, and the improvements are evident for both my body and well-being. Thank you for this product!
9.5
Helps with constipation
Probiotics have greatly improved my constipation. I began taking them at night to prevent bloating, and after a week, my intestines started functioning properly. I recommend this to anyone with similar issues. Please mark this review as useful if it helped you!
9.5
Notable improvement
I was constipated for almost 15 years. After a week of using this product, my stools have become beautifully shaped, and I'm no longer bloated. It's been an incredible change, and I highly recommend trying it.
9.5
Daily bowel movements
This probiotic has been a miracle for my 7-year-old daughter, who has suffered from severe constipation since birth. After trying various treatments with no success, I tried probiotics and mixed capsules into kefir overnight. We now have daily bowel movements! I even tested it on my grandmother with similar success. This product has truly changed our lives.
9.5
Bloating reduction
This supplement truly works! The kefir it produces is fantastic, and I no longer experience bloating. My gut health has improved significantly, and I am no longer afraid of constipation.
9.5
Elderly constipation relief
I bought this for my elderly mother with digestion issues and constipation. I gave her two capsules daily, and with triphala, they worked well together. I tried making yogurt using the capsule contents, which turned out delicious and effective in relieving her symptoms. We're both happy with the results.
9.5
Balanced digestion
I've learned it's better to alternate probiotic strains, so I use this alongside several others. Since I started, my irritable bowel syndrome symptoms have vanished, and my husband experienced relief from his stomach issues too. We both continue taking it for our health.
9.5
Supports digestion
I take one capsule each evening after dinner, which contains beneficial live bacteria. This product effectively promotes a healthy gut, and I’ve experienced relief from constipation since starting it. The capsules are easy to swallow and the quality is great, so I’ve purchased another bottle.
9.5
Relieved constipation
I'm in my late 30s and have struggled with constipation for over 20 years. Since taking this supplement, my daily routine has improved significantly. I take one pill before bed, and while results may vary by individual, this has been the best solution for my constipation.
We explored how two probiotic formulations, including Bifidobacterium bifidum, affected adults with functional constipation. Participants took an oral sachet daily for 30 days in a randomized controlled trial.

While we noticed some improvements in stool frequency and quality during the first week, the differences between different probiotic groups weren't statistically significant. Overall, the treatments were considered safe, with only one reported adverse event related to abdominal pain.

In short, probiotics show promise, but the results weren't strong enough to claim consistent effectiveness against constipation.
We explored the impact of multistrain probiotics, including Lactobacillus acidophilus, on functional constipation in elderly individuals living in a nursing home. In a controlled study with 60 participants, those receiving the probiotic mixture for 12 weeks showed a slight increase in stool frequency compared to the placebo group.

While the improvement was not significant overall, it became notable by the 71st day when not considering laxative use. This suggests that lactobacillus treatment could help constipation in seniors, although the effects may vary.
We aimed to explore how a specific probiotic mixture could help patients with uncomplicated diverticular disease of the colon, particularly those dealing with constipation-related abdominal pain.

In our study involving 46 patients, we found that after six months, 68% remained symptom-free, with over 78% rating the treatment as effective. This suggests that the symbiotic mixture, which included Lactobacillus acidophilus, can be beneficial in reducing constipation issues related to this condition.

Overall, it appears probiotics may play a positive role in managing constipation symptoms, offering a promising avenue for those affected.

References

  1. Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
  2. Šola KF, Vladimir-Knežević S, Hrabač P, Mucalo I, Saso L, et al. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. Eur J Clin Nutr. 2022;76:1675. doi:10.1038/s41430-022-01189-0
  3. Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial. BMC Nephrol. 2022;23:259. doi:10.1186/s12882-022-02890-9
  4. Mokhtar NM, Jaafar NM, Alfian E, Mohd Rathi ND, Abdul Rani R, et al. Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Acta Gastroenterol Belg. 2021;84:585. doi:10.51821/84.4.009
  5. Martoni CJ, Evans M, Chow CT, Chan LS, Leyer G. Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial. J Dig Dis. 2019;20:435. doi:10.1111/1751-2980.12797
  6. Airaksinen K, Yeung N, Lyra A, Lahtinen SJ, Huttunen T, et al. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial. Benef Microbes. 2019;10:617. doi:10.3920/BM2018.0163
  7. Magro DO, de Oliveira LM, Bernasconi I, Ruela Mde S, Credidio L, et al. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J. 2014;13:75. doi:10.1186/1475-2891-13-75
  8. Ohigashi S, Hoshino Y, Ohde S, Onodera H. Functional outcome, quality of life, and efficacy of probiotics in postoperative patients with colorectal cancer. Surg Today. 2011;41:1200. doi:10.1007/s00595-010-4450-6
  9. Tabbers MM, de Milliano I, Roseboom MG, Benninga MA. Is Bifidobacterium breve effective in the treatment of childhood constipation? Results from a pilot study. Nutr J. 2011;10:19. doi:10.1186/1475-2891-10-19
  10. Jeon JR, Choi JH. Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats. J Med Food. 2010;13:950. doi:10.1089/jmf.2009.1307
  11. Lamiki P, Tsuchiya J, Pathak S, Okura R, Solimene U, et al. Probiotics in diverticular disease of the colon: an open label study. J Gastrointestin Liver Dis. 2010;19:31.
  12. An HM, Baek EH, Jang S, Lee DK, Kim MJ, et al. Efficacy of Lactic Acid Bacteria (LAB) supplement in management of constipation among nursing home residents. Nutr J. 2010;9:5. doi:10.1186/1475-2891-9-5
  13. Drouault-Holowacz S, Bieuvelet S, Burckel A, Cazaubiel M, Dray X, et al. A double blind randomized controlled trial of a probiotic combination in 100 patients with irritable bowel syndrome. Gastroenterol Clin Biol. 2008;32:147. doi:10.1016/j.gcb.2007.06.001
  14. Astegiano M, Pellicano R, Terzi E, Simondi D, Rizzetto M. Treatment of irritable bowel syndrome. A case control experience. Minerva Gastroenterol Dietol. 2006;52:359.
  15. Tsuchiya J, Barreto R, Okura R, Kawakita S, Fesce E, et al. Single-blind follow-up study on the effectiveness of a symbiotic preparation in irritable bowel syndrome. Chin J Dig Dis. 2004;5:169.
  16. Alm L. [Acidophilus milk for therapy in gastrointestinal disorders]. Nahrung. 1984;28:683.
  17. Liao Y, Wang Y, Huang W, Wang J, Guo M, et al. L. acidophilus/L. johnsonii ratio affects slow transit constipation in rats. Sci Rep. 2024;14:21088. doi:10.1038/s41598-024-71945-8
  18. Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
  19. Gan D, Chen J, Tang X, Xiao L, Martoni CJ, et al. Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial. Front Microbiol. 2022;13:985308. doi:10.3389/fmicb.2022.985308
  20. Šola KF, Vladimir-Knežević S, Hrabač P, Mucalo I, Saso L, et al. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. Eur J Clin Nutr. 2022;76:1675. doi:10.1038/s41430-022-01189-0
  21. Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial. BMC Nephrol. 2022;23:259. doi:10.1186/s12882-022-02890-9
  22. Lin B, Zhao F, Liu Y, Wu X, Feng J, et al. Randomized Clinical Trial: Probiotics Alleviated Oral-Gut Microbiota Dysbiosis and Thyroid Hormone Withdrawal-Related Complications in Thyroid Cancer Patients Before Radioiodine Therapy Following Thyroidectomy. Front Endocrinol (Lausanne). 2022;13:834674. doi:10.3389/fendo.2022.834674
  23. Mokhtar NM, Jaafar NM, Alfian E, Mohd Rathi ND, Abdul Rani R, et al. Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Acta Gastroenterol Belg. 2021;84:585. doi:10.51821/84.4.009
  24. Martoni CJ, Evans M, Chow CT, Chan LS, Leyer G. Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial. J Dig Dis. 2019;20:435. doi:10.1111/1751-2980.12797
  25. Airaksinen K, Yeung N, Lyra A, Lahtinen SJ, Huttunen T, et al. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial. Benef Microbes. 2019;10:617. doi:10.3920/BM2018.0163
  26. Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. doi:10.1007/s12602-018-9401-3
  27. Kim BK, Choi IS, Kim J, Han SH, Suh HJ, et al. Effects of Fermented Milk with Mixed Strains as a Probiotic on the Inhibition of Loperamide-Induced Constipation. Korean J Food Sci Anim Resour. 2017;37:906. doi:10.5851/kosfa.2017.37.6.906
  28. Magro DO, de Oliveira LM, Bernasconi I, Ruela Mde S, Credidio L, et al. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J. 2014;13:75. doi:10.1186/1475-2891-13-75
  29. Ohigashi S, Hoshino Y, Ohde S, Onodera H. Functional outcome, quality of life, and efficacy of probiotics in postoperative patients with colorectal cancer. Surg Today. 2011;41:1200. doi:10.1007/s00595-010-4450-6
  30. Choi SC, Kim BJ, Rhee PL, Chang DK, Son HJ, et al. Probiotic Fermented Milk Containing Dietary Fiber Has Additive Effects in IBS with Constipation Compared to Plain Probiotic Fermented Milk. Gut Liver. 2011;5:22. doi:10.5009/gnl.2011.5.1.22
  31. Nova E, Viadel B, Wärnberg J, Carreres JE, Marcos A. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J Med Food. 2011;14:79. doi:10.1089/jmf.2008.0328
  32. Jeon JR, Choi JH. Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats. J Med Food. 2010;13:950. doi:10.1089/jmf.2009.1307
  33. Qiu B, Zhu L, Zhang S, Han S, Fei Y, et al. Prevention of Loperamide-Induced Constipation in Mice and Alteration of 5-Hydroxytryotamine Signaling by Li01. Nutrients. 2022;14. doi:10.3390/nu14194083
  34. Zhu S, Yu Q, Xue Y, Li J, Huang Y, et al. CCFM1163 alleviates cathartic colon by activating the BDNF-TrkB-PLC/IP pathway to reconstruct the intestinal nerve and barrier. Food Funct. 2025;16:2057. doi:10.1039/d4fo05835f
  35. Zhang C, Wang L, Liu X, Wang G, Zhao J, et al. subsp. relieves loperamide hydrochloride-induced constipation in mice by enhancing bile acid dissociation. Food Funct. 2025;16:297. doi:10.1039/d4fo04660a
  36. Hashimoto Y, Kobayashi G, Kitagawa N, Okada H, Hamaguchi M, et al. Protocol of efficacy of bifidobacteria intake on gastrointestinal symptoms in symptomatic type 2 diabetes mellitus patients in abdominis: An open-label, randomized controlled trial (Binary STAR study). PLoS One. 2024;19:e0295998. doi:10.1371/journal.pone.0295998
  37. Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
  38. Wang L, Wang L, Tian P, Wang B, Cui S, et al. A randomised, double-blind, placebo-controlled trial of CCFM16 for manipulation of the gut microbiota and relief from chronic constipation. Food Funct. 2022;13:1628. doi:10.1039/d1fo03896f
  39. Hata S, Nakajima H, Hashimoto Y, Miyoshi T, Hosomi Y, et al. Effects of probiotic Bifidobacterium bifidum G9-1 on the gastrointestinal symptoms of patients with type 2 diabetes mellitus treated with metformin: An open-label, single-arm, exploratory research trial. J Diabetes Investig. 2022;13:489. doi:10.1111/jdi.13698
  40. Chai M, Wang L, Li X, Zhao J, Zhang H, et al. Different strains change the intestinal flora composition of mice different mechanisms to alleviate loperamide-induced constipation. Food Funct. 2021;12:6058. doi:10.1039/d1fo00559f
  41. Fuyuki A, Higurashi T, Kessoku T, Ashikari K, Yoshihara T, et al. Efficacy of G9-1 in improving quality of life in patients with chronic constipation: a prospective intervention study. Biosci Microbiota Food Health. 2021;40:105. doi:10.12938/bmfh.2020-073
  42. Makizaki Y, Uemoto T, Yokota H, Yamamoto M, Tanaka Y, et al. Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis. PLoS One. 2021;16:e0248584. doi:10.1371/journal.pone.0248584
  43. Martoni CJ, Evans M, Chow CT, Chan LS, Leyer G. Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial. J Dig Dis. 2019;20:435. doi:10.1111/1751-2980.12797
  44. Makizaki Y, Maeda A, Oikawa Y, Tamura S, Tanaka Y, et al. Alleviation of low-fiber diet-induced constipation by probiotic G9-1 is based on correction of gut microbiota dysbiosis. Biosci Microbiota Food Health. 2019;38:49. doi:10.12938/bmfh.18-020
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