Last update
5/22/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 43 Researches
7.8
USERS' SCORE
Moderately Good
Based on 142 Reviews
7.4
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Proprietary Blend Containing 1 billion live cultures† Lactobacillus acidophilus Lactobacillus salivarius Bifidobacterium bifidum Streptococcus thermophilus
175 mg
**
Top Medical Research Studies
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
Read More
9
We explored the effects of Ligilactobacillus salivarius Li01 in a mouse model of constipation induced by loperamide. The findings show that Li01 can significantly improve symptoms of constipation by enhancing fecal water content and quantity, as well as promoting gut motility.
Additionally, Li01 seems to protect intestinal barrier structures and influence gut microbiota composition. By impacting the 5-HT signaling pathway, Li01 holds promise as a potential treatment for constipation. However, further research is necessary to fully understand its effects and applications.
Additionally, Li01 seems to protect intestinal barrier structures and influence gut microbiota composition. By impacting the 5-HT signaling pathway, Li01 holds promise as a potential treatment for constipation. However, further research is necessary to fully understand its effects and applications.
Read More
9
We explored the potential of various Bifidobacterium strains to alleviate constipation in mice caused by loperamide hydrochloride. Throughout 17 days of treatment, we administered six different strains and assessed their effects on gastrointestinal health.
Notably, only one strain showed significant benefits in improving stool consistency and enhancing gut function. This strain not only helped restore bile and fatty acid levels but also positively altered the gut microbiota of constipated mice. Our findings indicate that Bifidobacterium can be effective in managing constipation through its unique physiological capabilities.
Notably, only one strain showed significant benefits in improving stool consistency and enhancing gut function. This strain not only helped restore bile and fatty acid levels but also positively altered the gut microbiota of constipated mice. Our findings indicate that Bifidobacterium can be effective in managing constipation through its unique physiological capabilities.
Read More
Most Useful Reviews
9
Daily bowel movements
142 people found this helpful
This probiotic has been a miracle for my 7-year-old daughter, who has suffered from severe constipation since birth. After trying various treatments with no success, I tried probiotics and mixed capsules into kefir overnight. We now have daily bowel movements! I even tested it on my grandmother with similar success. This product has truly changed our lives.
Read More
9
Effective capsules
105 people found this helpful
Excellent quality! The ingredients are good, with small capsules that are easy to take. I experienced a significant improvement in constipation, and my intestines now function properly.
Read More
9
Bloating reduction
81 people found this helpful
This supplement truly works! The kefir it produces is fantastic, and I no longer experience bloating. My gut health has improved significantly, and I am no longer afraid of constipation.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 43 Researches
7.8
- All Researches
9.5
Cultured milk drink relieves constipation
We explored the impact of a cultured milk drink containing Lactobacillus acidophilus on constipation symptoms in adults with constipation-predominant irritable bowel syndrome (IBS-C). Over 30 days, 77 participants drank this yogurt-like beverage daily.
Post-treatment, a staggering 97.4% of participants reported improvement in their symptoms, including decreased intestinal transit time and lower fecal pH. Notably, the levels of inflammatory cytokines also dropped significantly, suggesting potential benefits of this treatment for IBS-C patients.
Post-treatment, a staggering 97.4% of participants reported improvement in their symptoms, including decreased intestinal transit time and lower fecal pH. Notably, the levels of inflammatory cytokines also dropped significantly, suggesting potential benefits of this treatment for IBS-C patients.
Read More
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
Read More
9
We evaluated how lactobacillus acidophilus, both alone and in a mix with other bacteria, might relieve constipation caused by loperamide in rats. Over 14 days, we noticed that the groups receiving probiotics had significantly heavier and wetter stools compared to control animals.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Notably, the CKDBP group, a blend of multiple bacteria, showed the greatest improvement in intestinal transit. Measures like mucosal length and mucus secretion were also significantly enhanced in all probiotic-treated groups, highlighting their potential to alleviate constipation symptoms effectively.
Read More
9
We explored the effects of Ligilactobacillus salivarius Li01 in a mouse model of constipation induced by loperamide. The findings show that Li01 can significantly improve symptoms of constipation by enhancing fecal water content and quantity, as well as promoting gut motility.
Additionally, Li01 seems to protect intestinal barrier structures and influence gut microbiota composition. By impacting the 5-HT signaling pathway, Li01 holds promise as a potential treatment for constipation. However, further research is necessary to fully understand its effects and applications.
Additionally, Li01 seems to protect intestinal barrier structures and influence gut microbiota composition. By impacting the 5-HT signaling pathway, Li01 holds promise as a potential treatment for constipation. However, further research is necessary to fully understand its effects and applications.
Read More
9
We explored the potential of various Bifidobacterium strains to alleviate constipation in mice caused by loperamide hydrochloride. Throughout 17 days of treatment, we administered six different strains and assessed their effects on gastrointestinal health.
Notably, only one strain showed significant benefits in improving stool consistency and enhancing gut function. This strain not only helped restore bile and fatty acid levels but also positively altered the gut microbiota of constipated mice. Our findings indicate that Bifidobacterium can be effective in managing constipation through its unique physiological capabilities.
Notably, only one strain showed significant benefits in improving stool consistency and enhancing gut function. This strain not only helped restore bile and fatty acid levels but also positively altered the gut microbiota of constipated mice. Our findings indicate that Bifidobacterium can be effective in managing constipation through its unique physiological capabilities.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 142 Reviews
7.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Daily bowel movements
142 people found this helpful
This probiotic has been a miracle for my 7-year-old daughter, who has suffered from severe constipation since birth. After trying various treatments with no success, I tried probiotics and mixed capsules into kefir overnight. We now have daily bowel movements! I even tested it on my grandmother with similar success. This product has truly changed our lives.
Read More
9
Effective capsules
105 people found this helpful
Excellent quality! The ingredients are good, with small capsules that are easy to take. I experienced a significant improvement in constipation, and my intestines now function properly.
Read More
9
Bloating reduction
81 people found this helpful
This supplement truly works! The kefir it produces is fantastic, and I no longer experience bloating. My gut health has improved significantly, and I am no longer afraid of constipation.
Read More
9
Helps with constipation
46 people found this helpful
Probiotics have greatly improved my constipation. I began taking them at night to prevent bloating, and after a week, my intestines started functioning properly. I recommend this to anyone with similar issues. Please mark this review as useful if it helped you!
Read More
9
Supports digestion
16 people found this helpful
I take one capsule each evening after dinner, which contains beneficial live bacteria. This product effectively promotes a healthy gut, and I’ve experienced relief from constipation since starting it. The capsules are easy to swallow and the quality is great, so I’ve purchased another bottle.
Read More
Frequently Asked Questions
9
Effective remedy
9 people found this helpful
I've faced ongoing constipation, and after just two days of taking this probiotic at night, my bowel movements have improved significantly. It was a pleasant surprise, and the capsules last a long time.
9
Helps with constipation
46 people found this helpful
Probiotics have greatly improved my constipation. I began taking them at night to prevent bloating, and after a week, my intestines started functioning properly. I recommend this to anyone with similar issues. Please mark this review as useful if it helped you!
9
Daily bowel movements
142 people found this helpful
This probiotic has been a miracle for my 7-year-old daughter, who has suffered from severe constipation since birth. After trying various treatments with no success, I tried probiotics and mixed capsules into kefir overnight. We now have daily bowel movements! I even tested it on my grandmother with similar success. This product has truly changed our lives.
9
Bloating reduction
81 people found this helpful
This supplement truly works! The kefir it produces is fantastic, and I no longer experience bloating. My gut health has improved significantly, and I am no longer afraid of constipation.
9
Supports digestion
16 people found this helpful
I take one capsule each evening after dinner, which contains beneficial live bacteria. This product effectively promotes a healthy gut, and I’ve experienced relief from constipation since starting it. The capsules are easy to swallow and the quality is great, so I’ve purchased another bottle.
9
Relieved constipation
14 people found this helpful
I'm in my late 30s and have struggled with constipation for over 20 years. Since taking this supplement, my daily routine has improved significantly. I take one pill before bed, and while results may vary by individual, this has been the best solution for my constipation.
7
We explored the effects of two different probiotic formulations designed to tackle functional constipation in adults. Participants took an oral sachet daily for 30 days in a randomized, double-blind trial.
Both probiotic mixes improved constipation symptoms by increasing the frequency of bowel movements and enhancing stool quality. However, no significant differences were found among the treatment groups. Overall, the probiotics were safe, with only one report of abdominal pain in a participant.
Both probiotic mixes improved constipation symptoms by increasing the frequency of bowel movements and enhancing stool quality. However, no significant differences were found among the treatment groups. Overall, the probiotics were safe, with only one report of abdominal pain in a participant.
7
We studied the effects of multistrain probiotics on constipation in elderly nursing home residents. Sixty participants took either a specific probiotic mixture or a placebo over 12 weeks in a double-blind setup.
While there was a slight but not statistically significant increase in stool frequency overall, those receiving probiotics showed a notable increase in stool frequency post-day 71 when laxative use was considered.
Overall, the probiotics were well tolerated and deemed safe for treating functional constipation in this population.
While there was a slight but not statistically significant increase in stool frequency overall, those receiving probiotics showed a notable increase in stool frequency post-day 71 when laxative use was considered.
Overall, the probiotics were well tolerated and deemed safe for treating functional constipation in this population.
8
We aimed to explore how a specific probiotic mixture could help patients with uncomplicated diverticular disease of the colon, particularly those dealing with constipation-related abdominal pain.
In our study involving 46 patients, we found that after six months, 68% remained symptom-free, with over 78% rating the treatment as effective. This suggests that the symbiotic mixture, which included Lactobacillus acidophilus, can be beneficial in reducing constipation issues related to this condition.
Overall, it appears probiotics may play a positive role in managing constipation symptoms, offering a promising avenue for those affected.
In our study involving 46 patients, we found that after six months, 68% remained symptom-free, with over 78% rating the treatment as effective. This suggests that the symbiotic mixture, which included Lactobacillus acidophilus, can be beneficial in reducing constipation issues related to this condition.
Overall, it appears probiotics may play a positive role in managing constipation symptoms, offering a promising avenue for those affected.
References
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- Šola KF, Vladimir-Knežević S, Hrabač P, Mucalo I, Saso L, et al. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. Eur J Clin Nutr. 2022;76:1675. 10.1038/s41430-022-01189-0
- Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial. BMC Nephrol. 2022;23:259. 10.1186/s12882-022-02890-9
- Mokhtar NM, Jaafar NM, Alfian E, Mohd Rathi ND, Abdul Rani R, et al. Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Acta Gastroenterol Belg. 2021;84:585. 10.51821/84.4.009
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- Gan D, Chen J, Tang X, Xiao L, Martoni CJ, et al. Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial. Front Microbiol. 2022;13:985308. 10.3389/fmicb.2022.985308
- Lin B, Zhao F, Liu Y, Wu X, Feng J, et al. Randomized Clinical Trial: Probiotics Alleviated Oral-Gut Microbiota Dysbiosis and Thyroid Hormone Withdrawal-Related Complications in Thyroid Cancer Patients Before Radioiodine Therapy Following Thyroidectomy. Front Endocrinol (Lausanne). 2022;13:834674. 10.3389/fendo.2022.834674
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- Kim BK, Choi IS, Kim J, Han SH, Suh HJ, et al. Effects of Fermented Milk with Mixed Strains as a Probiotic on the Inhibition of Loperamide-Induced Constipation. Korean J Food Sci Anim Resour. 2017;37:906. 10.5851/kosfa.2017.37.6.906
- Choi SC, Kim BJ, Rhee PL, Chang DK, Son HJ, et al. Probiotic Fermented Milk Containing Dietary Fiber Has Additive Effects in IBS with Constipation Compared to Plain Probiotic Fermented Milk. Gut Liver. 2011;5:22. 10.5009/gnl.2011.5.1.22
- Nova E, Viadel B, Wärnberg J, Carreres JE, Marcos A. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J Med Food. 2011;14:79. 10.1089/jmf.2008.0328
- Qiu B, Zhu L, Zhang S, Han S, Fei Y, et al. Prevention of Loperamide-Induced Constipation in Mice and Alteration of 5-Hydroxytryotamine Signaling by Li01. Nutrients. 2022;14. 10.3390/nu14194083
- Zhu S, Yu Q, Xue Y, Li J, Huang Y, et al. CCFM1163 alleviates cathartic colon by activating the BDNF-TrkB-PLC/IP pathway to reconstruct the intestinal nerve and barrier. Food Funct. 2025;16:2057. 10.1039/d4fo05835f
- Zhang C, Wang L, Liu X, Wang G, Zhao J, et al. subsp. relieves loperamide hydrochloride-induced constipation in mice by enhancing bile acid dissociation. Food Funct. 2025;16:297. 10.1039/d4fo04660a
- Hashimoto Y, Kobayashi G, Kitagawa N, Okada H, Hamaguchi M, et al. Protocol of efficacy of bifidobacteria intake on gastrointestinal symptoms in symptomatic type 2 diabetes mellitus patients in abdominis: An open-label, randomized controlled trial (Binary STAR study). PLoS One. 2024;19:e0295998. 10.1371/journal.pone.0295998
- Wang L, Wang L, Tian P, Wang B, Cui S, et al. A randomised, double-blind, placebo-controlled trial of CCFM16 for manipulation of the gut microbiota and relief from chronic constipation. Food Funct. 2022;13:1628. 10.1039/d1fo03896f
- Hata S, Nakajima H, Hashimoto Y, Miyoshi T, Hosomi Y, et al. Effects of probiotic Bifidobacterium bifidum G9-1 on the gastrointestinal symptoms of patients with type 2 diabetes mellitus treated with metformin: An open-label, single-arm, exploratory research trial. J Diabetes Investig. 2022;13:489. 10.1111/jdi.13698
- Chai M, Wang L, Li X, Zhao J, Zhang H, et al. Different strains change the intestinal flora composition of mice different mechanisms to alleviate loperamide-induced constipation. Food Funct. 2021;12:6058. 10.1039/d1fo00559f
- Fuyuki A, Higurashi T, Kessoku T, Ashikari K, Yoshihara T, et al. Efficacy of G9-1 in improving quality of life in patients with chronic constipation: a prospective intervention study. Biosci Microbiota Food Health. 2021;40:105. 10.12938/bmfh.2020-073
- Makizaki Y, Uemoto T, Yokota H, Yamamoto M, Tanaka Y, et al. Improvement of loperamide-induced slow transit constipation by Bifidobacterium bifidum G9-1 is mediated by the correction of butyrate production and neurotransmitter profile due to improvement in dysbiosis. PLoS One. 2021;16:e0248584. 10.1371/journal.pone.0248584
- Makizaki Y, Maeda A, Oikawa Y, Tamura S, Tanaka Y, et al. Alleviation of low-fiber diet-induced constipation by probiotic G9-1 is based on correction of gut microbiota dysbiosis. Biosci Microbiota Food Health. 2019;38:49. 10.12938/bmfh.18-020
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- de Milliano I, Tabbers MM, van der Post JA, Benninga MA. Is a multispecies probiotic mixture effective in constipation during pregnancy? 'A pilot study'. Nutr J. 2012;11:80. 10.1186/1475-2891-11-80
- Ishizuka A, Tomizuka K, Aoki R, Nishijima T, Saito Y, et al. Effects of administration of Bifidobacterium animalis subsp. lactis GCL2505 on defecation frequency and bifidobacterial microbiota composition in humans. J Biosci Bioeng. 2012;113:587. 10.1016/j.jbiosc.2011.12.016
- Eor JY, Tan PL, Lim SM, Choi DH, Yoon SM, et al. Laxative effect of probiotic chocolate on loperamide-induced constipation in rats. Food Res Int. 2019;116:1173. 10.1016/j.foodres.2018.09.062
- Yoon JY, Cha JM, Oh JK, Tan PL, Kim SH, et al. Probiotics Ameliorate Stool Consistency in Patients with Chronic Constipation: A Randomized, Double-Blind, Placebo-Controlled Study. Dig Dis Sci. 2018;63:2754. 10.1007/s10620-018-5139-8
- Feng JR, Wang F, Qiu X, McFarland LV, Chen PF, et al. Efficacy and safety of probiotic-supplemented triple therapy for eradication of Helicobacter pylori in children: a systematic review and network meta-analysis. Eur J Clin Pharmacol. 2017;73:1199. 10.1007/s00228-017-2291-6
- Ivakhnenko ES, Nian'kovskiĭ SL. [Effect of probiotics on the dynamics of gastrointestinal symptoms of food allergy to cow's milk protein in infants]. Georgian Med News. 2013. PubMed
- Higashikawa F, Noda M, Awaya T, Nomura K, Oku H, et al. Improvement of constipation and liver function by plant-derived lactic acid bacteria: a double-blind, randomized trial. Nutrition. 2010;26:367. 10.1016/j.nut.2009.05.008
