Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.5
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
667 mcg DFE (400 mcg Folic Acid)
167%
Calcium (as Calcium Carbonate)
100 mg
8%
Top Medical Research Studies
9
We developed a folic acid-targeted liposome system to improve the delivery of sorafenib, a drug used in treating liver cancer. Through various techniques, we created liposomes loaded with sorafenib and evaluated their effects on liver cancer cells. Our results showed that this targeted system effectively inhibited cancer cell growth and induced apoptosis in vitro. Additionally, in a liver xenograft model, it successfully slowed tumor progression. Overall, our findings suggest that this targeted delivery method could enhance liver cancer therapy while minimizing side effects.
9
Folate-targeted nanoparticle therapy
We explored the potential of mesoporous silica nanoparticles (MSNs) enhanced with folic acid (FA) to deliver the chemotherapy drug epirubicin (EPI) effectively in breast cancer treatment.
Our research showed that this targeted delivery system significantly inhibited cancer cell growth both in laboratory settings and in mice. Notably, it encouraged cancer cell death through various molecular pathways while avoiding toxicity in other organs.
These findings suggest that folic acid's targeting ability may greatly enhance the effectiveness of anticancer therapies like epirubicin.
Our research showed that this targeted delivery system significantly inhibited cancer cell growth both in laboratory settings and in mice. Notably, it encouraged cancer cell death through various molecular pathways while avoiding toxicity in other organs.
These findings suggest that folic acid's targeting ability may greatly enhance the effectiveness of anticancer therapies like epirubicin.
9
We explored innovative ways to improve cancer treatment by using folate-targeted nanoparticles. The study focused on the development of chitosan nanoparticles that mimic cell membranes, enhancing their ability to evade the immune system and prolong circulation in the body. By integrating folate, a nutrient known to target cancer cells, we hoped to increase the effectiveness of drug delivery directly to tumors.
Our findings revealed that these folate-targeted nanoparticles showed a remarkable capacity to be absorbed by breast cancer cells, specifically increasing uptake efficiency by five to six times compared to nanoparticles without folate. This was a significant boost, showcasing the potential of using folate as a guiding factor for cancer treatment.
Furthermore, the study demonstrated that these nanoparticles remained in the bloodstream for much longer, with their half-life extended from roughly 2.7 hours to nearly 13 hours. This means they can circulate longer and potentially reach tumors more effectively.
Ultimately, our research aims to pave the way for more efficient cancer therapies, highlighting how leveraging folate in nanoparticle design may provide a promising strategy in the fight against cancer.
Our findings revealed that these folate-targeted nanoparticles showed a remarkable capacity to be absorbed by breast cancer cells, specifically increasing uptake efficiency by five to six times compared to nanoparticles without folate. This was a significant boost, showcasing the potential of using folate as a guiding factor for cancer treatment.
Furthermore, the study demonstrated that these nanoparticles remained in the bloodstream for much longer, with their half-life extended from roughly 2.7 hours to nearly 13 hours. This means they can circulate longer and potentially reach tumors more effectively.
Ultimately, our research aims to pave the way for more efficient cancer therapies, highlighting how leveraging folate in nanoparticle design may provide a promising strategy in the fight against cancer.
Most Useful Reviews
9
Reduces stomach cancer
During times of stress, like war, one folic acid tablet significantly reduces the risk of stomach cancer from alcohol consumption.
9
Maintains cell integrity
Folic acid aids the body in producing and maintaining new cells, as well as preventing DNA alterations that could lead to cancer.
7.5
Cell protection
Firstly, I feel that it is necessary for everyone at least once. It plays a key role in brain health and combats cancer, protects cells, and increases red blood cell production. It's beneficial for anxiety, stress, and crucial before pregnancy.
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.5
- All Researches
9.5
Nanoparticle-assisted targeted cancer therapy
We explored the use of nanosecond laser pulses combined with doxorubicin-loaded gold nanoparticles (AuNPs) to target folate receptor-positive cancer cells. This innovative method allowed for the efficient release of the drug while inducing localized cell damage through thermal effects.
By testing different nanoparticle concentrations and laser settings, we observed near-complete tumor cell destruction in pinpointed areas, sparing nearby healthy cells. The results emphasized the potential of this approach for developing safer and more effective cancer therapies.
By testing different nanoparticle concentrations and laser settings, we observed near-complete tumor cell destruction in pinpointed areas, sparing nearby healthy cells. The results emphasized the potential of this approach for developing safer and more effective cancer therapies.
9.5
We examined a new approach to enhance cancer treatment by developing targeted nanogels using folic acid to deliver 5-aminolevulinic acid (5-ALA) more effectively.
By using special nanoparticles, we found that these nanogels significantly improved the delivery of 5-ALA to tumor cells, enhancing the effectiveness of photodynamic therapy.
Our in vivo experiments indicated that these nanogels notably reduced the growth of skin cancer.
Overall, this innovative delivery system shows great promise in boosting the therapeutic effects of 5-ALA against skin cancer.
By using special nanoparticles, we found that these nanogels significantly improved the delivery of 5-ALA to tumor cells, enhancing the effectiveness of photodynamic therapy.
Our in vivo experiments indicated that these nanogels notably reduced the growth of skin cancer.
Overall, this innovative delivery system shows great promise in boosting the therapeutic effects of 5-ALA against skin cancer.
9
We developed a folic acid-targeted liposome system to improve the delivery of sorafenib, a drug used in treating liver cancer. Through various techniques, we created liposomes loaded with sorafenib and evaluated their effects on liver cancer cells. Our results showed that this targeted system effectively inhibited cancer cell growth and induced apoptosis in vitro. Additionally, in a liver xenograft model, it successfully slowed tumor progression. Overall, our findings suggest that this targeted delivery method could enhance liver cancer therapy while minimizing side effects.
9
Folate-targeted nanoparticle therapy
We explored the potential of mesoporous silica nanoparticles (MSNs) enhanced with folic acid (FA) to deliver the chemotherapy drug epirubicin (EPI) effectively in breast cancer treatment.
Our research showed that this targeted delivery system significantly inhibited cancer cell growth both in laboratory settings and in mice. Notably, it encouraged cancer cell death through various molecular pathways while avoiding toxicity in other organs.
These findings suggest that folic acid's targeting ability may greatly enhance the effectiveness of anticancer therapies like epirubicin.
Our research showed that this targeted delivery system significantly inhibited cancer cell growth both in laboratory settings and in mice. Notably, it encouraged cancer cell death through various molecular pathways while avoiding toxicity in other organs.
These findings suggest that folic acid's targeting ability may greatly enhance the effectiveness of anticancer therapies like epirubicin.
9
We explored the use of folic acid-conjugated magnetic nanoparticles for improving cancer treatment. These nanoparticles, loaded with the chemotherapy drug doxorubicin, were designed to target cancer cells that overexpress folate receptors.
The study found that these nanoparticles allow for better drug delivery and increased cytotoxicity against certain cancer cells. They showed effective drug release, especially in acidic environments typical of cancer cells.
Overall, while the nanoparticles enhanced the drug delivery mechanism, the study indicates that the overall benefit from folic acid was primarily in improving drug uptake rather than a transformative impact on treatment outcomes.
The study found that these nanoparticles allow for better drug delivery and increased cytotoxicity against certain cancer cells. They showed effective drug release, especially in acidic environments typical of cancer cells.
Overall, while the nanoparticles enhanced the drug delivery mechanism, the study indicates that the overall benefit from folic acid was primarily in improving drug uptake rather than a transformative impact on treatment outcomes.
User Reviews
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduces stomach cancer
During times of stress, like war, one folic acid tablet significantly reduces the risk of stomach cancer from alcohol consumption.
9
Maintains cell integrity
Folic acid aids the body in producing and maintaining new cells, as well as preventing DNA alterations that could lead to cancer.
7.5
Cell protection
Firstly, I feel that it is necessary for everyone at least once. It plays a key role in brain health and combats cancer, protects cells, and increases red blood cell production. It's beneficial for anxiety, stress, and crucial before pregnancy.
7.5
Essential for immunity
250 tablets is so much, enough for a long time. I take one daily. Folic acid is crucial for the growth and development of the immune system, heart, and brain health, as well as cancer prevention. It helps control blood sugar levels. The price-quality ratio is excellent. I will order more when it runs out.
6
Effective for health
It feels effective! I take it to help my body produce red blood cells. Taking it around my menstrual cycle has improved my condition and reduced dizziness. Research shows that adequate folic acid intake can protect from strokes, heart attacks, cancer, and mental disorders.
Frequently Asked Questions
6
Effective for health
It feels effective! I take it to help my body produce red blood cells. Taking it around my menstrual cycle has improved my condition and reduced dizziness. Research shows that adequate folic acid intake can protect from strokes, heart attacks, cancer, and mental disorders.
9
Reduces stomach cancer
During times of stress, like war, one folic acid tablet significantly reduces the risk of stomach cancer from alcohol consumption.
6
Prevents cell growth issues
Folic acid is vital when there is a deficiency in the body, especially for pregnancy-related anaemia and for those on antiepileptic medications. It promotes new cell growth, maintaining DNA integrity, thus preventing cancer.
6
Supports bone marrow
Folic acid is essential for bone marrow, assisting in neurotransmitter synthesis necessary for appetite, sleep, mood, and reducing cancer development.
7.5
Essential for immunity
250 tablets is so much, enough for a long time. I take one daily. Folic acid is crucial for the growth and development of the immune system, heart, and brain health, as well as cancer prevention. It helps control blood sugar levels. The price-quality ratio is excellent. I will order more when it runs out.
9
Maintains cell integrity
Folic acid aids the body in producing and maintaining new cells, as well as preventing DNA alterations that could lead to cancer.
6
Prevents tumour growth
Folic acid is a vital synthesis of the substance folate (B9). It plays an essential role in maintaining cell membrane integrity, cell division, and synthesising blood cells. It prevents the growth of tumours, hence aiding in cancer prevention. It is crucial for our immunity, metabolism, and cardiovascular health. I take this as prescribed by my doctor during breakfast.
6
Enhances mood stability
Folic acid is vital for bone marrow and aids in neurotransmitter synthesis, which supports normal appetite, sleep, mood, and helps reduce cancer development.
8
Folic acid-modified nanoparticles enhance treatment
We explored the effectiveness of folic acid when combined with biodegradable nanoparticles delivering the drug letrozole in breast cancer therapy. These specialized nanoparticles showed improved drug release in acidic environments, which are typical in tumors.
Notably, the folic acid-modified particles (LTZ-FNPs) demonstrated greater toxicity to breast cancer cells compared to standard nanoparticles. This method not only encouraged cancer cell death but also altered gene expression to inhibit cell invasion.
While the results are promising, suggesting enhanced treatment potential, they do not confirm that folic acid alone significantly improves overall cancer outcomes.
Notably, the folic acid-modified particles (LTZ-FNPs) demonstrated greater toxicity to breast cancer cells compared to standard nanoparticles. This method not only encouraged cancer cell death but also altered gene expression to inhibit cell invasion.
While the results are promising, suggesting enhanced treatment potential, they do not confirm that folic acid alone significantly improves overall cancer outcomes.
8
We investigated a new approach to tackle drug resistance in breast cancer cells, particularly focusing on P-glycoprotein (P-gp), a key player in this issue. By pairing a P-gp inhibitor with folic acid, we aimed to leverage folate receptors that are abundant on cancer cells for enhanced targeting.
Our in vitro tests with MCF-7/ADR cells showed that this folic acid conjugate effectively reversed drug resistance, maintaining similar efficacy to the original inhibitor. Additionally, animal tests demonstrated that this conjugate is not only potent but also safe, especially when combined with doxorubicin.
Our in vitro tests with MCF-7/ADR cells showed that this folic acid conjugate effectively reversed drug resistance, maintaining similar efficacy to the original inhibitor. Additionally, animal tests demonstrated that this conjugate is not only potent but also safe, especially when combined with doxorubicin.
9
We developed a folic acid-targeted liposome system to improve the delivery of sorafenib, a drug used in treating liver cancer. Through various techniques, we created liposomes loaded with sorafenib and evaluated their effects on liver cancer cells. Our results showed that this targeted system effectively inhibited cancer cell growth and induced apoptosis in vitro. Additionally, in a liver xenograft model, it successfully slowed tumor progression. Overall, our findings suggest that this targeted delivery method could enhance liver cancer therapy while minimizing side effects.
9
Folate-targeted nanoparticle therapy
We explored the potential of mesoporous silica nanoparticles (MSNs) enhanced with folic acid (FA) to deliver the chemotherapy drug epirubicin (EPI) effectively in breast cancer treatment.
Our research showed that this targeted delivery system significantly inhibited cancer cell growth both in laboratory settings and in mice. Notably, it encouraged cancer cell death through various molecular pathways while avoiding toxicity in other organs.
These findings suggest that folic acid's targeting ability may greatly enhance the effectiveness of anticancer therapies like epirubicin.
Our research showed that this targeted delivery system significantly inhibited cancer cell growth both in laboratory settings and in mice. Notably, it encouraged cancer cell death through various molecular pathways while avoiding toxicity in other organs.
These findings suggest that folic acid's targeting ability may greatly enhance the effectiveness of anticancer therapies like epirubicin.
References
- Rostami N, Nikzad A, Shaybani S, Noei H, Ghebleh A, et al. Engineering Folic Acid-Modified Nanoparticles to Enhance Letrozole's Anticancer Action. Macromol Biosci. 2025. doi:10.1002/mabi.202400558
- Li Y, Wang Q, Yang N, Yan H, Zhu Y, et al. Novel Folate-phenylfuran P-gp Inhibitor Conjugates for Overcoming Multidrug Resistance in MCF-7/ADR Cell. ChemMedChem. 2025. doi:10.1002/cmdc.202500216
- Goemaere I, Cielo A, Daniele R, Mastrotto F, De Smedt SC, et al. Nanosecond Laser Pulses Facilitating Efficient and Specific Cell Killing with Doxorubicin-Loaded Gold Nanoparticles Targeted to the Folate Receptor. Small Sci. 2025;5:2400234. doi:10.1002/smsc.202400234
- Patki SR, P SS, Manjappa AS, Veerachamy A, Sankaranarayanan M, et al. Identification of Active Phytochemicals to Inhibit Signal Transducer and Activator of Transcription 5A (STAT5A) Dimerization for Prostate Cancer Therapy: An In Silico Approach. Anticancer Agents Med Chem. 2025. doi:10.2174/0118715206367609250329195533
- Liu X, Zhang Y, Zhang P, Ge K, Zhang R, et al. Preparation of targeting nanogels for controlled delivery of 5-aminolevulinic acid triggered by matrix metalloproteinases as photodynamic therapy. Biointerphases. 2025;20. doi:10.1116/6.0004203
- Liu S, Yi D, Ma R, Zhang W. Folic Acid-Targeted Liposome-Based Nanoparticle Loaded with Sorafenib for Liver Cancer Therapy. Int J Nanomedicine. 2025;20:3933. doi:10.2147/IJN.S489777
- Farsani NK, Afshari S, Poor AS, Toutounchi A, Shahbazi Z, et al. pH-responsive mesoporous silica nanoparticles functionalized with folic acid and chitosan for targeted epirubicin delivery: In vitro and in vivo efficacy in breast cancer. Int J Biol Macromol. 2025;309:142558. doi:10.1016/j.ijbiomac.2025.142558
- Dash BS, Lai YC, Chen JP. Folic Acid-Conjugated Magnetic Oleoyl-Chitosan Nanoparticles for Controlled Release of Doxorubicin in Cancer Therapy. Nanomaterials (Basel). 2025;15. doi:10.3390/nano15060415
- Xie F, Liu N, Liu X, Feng X, Yang Z, et al. Insights into folic acid functionalization of self-assembled octenyl succinic anhydride starch micelles towards targeted delivery of selenium nanoparticles. Int J Biol Macromol. 2025;308:142352. doi:10.1016/j.ijbiomac.2025.142352
- Nalawade S, Narwade M, Deshmukh V, Nasir N, Wahab S, et al. Surface-modified nintedanib-loaded solid lipid nanoparticles for effective targeting of non-small cell lung cancer. Colloids Surf B Biointerfaces. 2025;251:114622. doi:10.1016/j.colsurfb.2025.114622
- Serag E, El-Fakharany EM, Hammad SF, El-Khouly ME. Metal-organic framework MIL-101(Fe) functionalized with folic acid as a multifunctional nanocarrier for targeted chemotherapy-photodynamic therapy. Biomater Sci. 2025. doi:10.1039/d4bm01738b
- Ghosh T, Mandal M, Shee M, Das TK, Mandal M, et al. Fabrication of Folic Acid-Derived Carbon Dot-Conjugated Chitosan Nanospheres as Theragnostic Agents for pH-Responsive Anticancer Drug Delivery. ACS Appl Bio Mater. 2025;8:3096. doi:10.1021/acsabm.4c01962
- Kucerova L, Fekiacova A, Udvorkova N, Malcharkova P, Blahova V, et al. Mirvetuximab Soravtansine Induces Potent Cytotoxicity and Bystander Effect in Cisplatin-Resistant Germ Cell Tumor Cells. Cells. 2025;14. doi:10.3390/cells14040287
- Kim J, Kim M, Han H, Kim S, Lahiji SF, et al. Dual-delivery of exosome inhibitor and immune-activating gene via lipid nano-assemblies for tumor immune evasion inhibition. J Control Release. 2025;381:113569. doi:10.1016/j.jconrel.2025.02.065
- Auchynnikava T, Äärelä A, Moisio O, Liljenbäck H, Andriana P, et al. Biological Evaluation of Molecular Spherical Nucleic Acids: Targeting Tumors via a Hybridization-Based Folate Decoration. ACS Omega. 2025;10:6003. doi:10.1021/acsomega.4c10047
- Lotter C, Stierli MA, Puligilla RD, Huwyler J. Dual targeted lipid nanoparticles for enhanced DNA delivery and transfection of breast cancer cells. Eur J Pharm Biopharm. 2025. doi:10.1016/j.ejpb.2025.114674
- Qi P, Chen L, Ma A, Zhang Y, Lin H, et al. Genetically predicted vitamins supplementation and risk of skin cancers: a Mendelian randomization study. Discov Oncol. 2025;16:204. doi:10.1007/s12672-025-01905-9
- Morshedi B, Esfandyari-Manesh M, Atyabi F, Ghahremani MH, Dinarvand R. Local delivery of ibrutinib by folate receptor-mediated targeting PLGA-PEG nanoparticles to glioblastoma multiform: and studies. J Drug Target. 2025. doi:10.1080/1061186X.2025.2468749
- Atci MM, Secmeler S, Sakin A, Arici S, Can O, et al. Perioperative 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) regimen in gastric cancer: Pathological regression grade and its relationship to clinical outcome. Indian J Cancer. 2024;61:714. doi:10.4103/ijc.IJC_1283_20
- Qin J, Ouyang C, Zhuang X. Association between folate and glutamine metabolism and prognosis of kidney cancer. Front Nutr. 2024;11:1506967. doi:10.3389/fnut.2024.1506967
- Konishi K, Fukumoto Y, Minoji T, Muranishi K, Nishigaki T, et al. [A Case of Sigmoid Colon Cancer with Bladder Invasion Successfully Treated with Chemotherapy with mFOLFOX6+Cetuximab]. Gan To Kagaku Ryoho. 2024;51:1797.
- Xie M, Zhao J, Feng X, Gao X, Cheng W, et al. Cell membrane-inspired chitosan nanoparticles for prolonged circulation and tumor-targeted drug delivery. Int J Biol Macromol. 2025;304:140934. doi:10.1016/j.ijbiomac.2025.140934
