NOW Supplements Silymarin Milk Thistle Extract

13 people found this helpful

Seriously, how could one manage without this product? It is incredibly effective. My entire family has used it for years, providing a wonderful feeling of lightness. I realised how crucial it is, especially considering the potential harm from medications and alcohol on the liver. This plant protects and cleanses the liver, making one feel revitalised. Many of us experience a burden from our stomachs and livers due to modern living. The milk thistle, in my opinion, is essential for every household. It alleviates abdominal pain, bloating, and discomfort after consuming gluten and white flour. It also aids in clearing trapped gases that lead to malaise. I highly recommend it to all!

Hashimoto details

I purchased this milk thistle supplement from iHerb to enhance my immunity and detoxify my liver. Alongside other supplements, it has greatly improved my Hashimoto's thyroiditis. Thank you very much.

Hypothyroidism details

Compensates thyroid function

This is an excellent drug for my hypothyroidism. It has successfully balanced my thyroid function. Additionally, it's a fantastic antioxidant.

Pancreatitis details

Silymarin promotes pancreatic cell growth

Soto C, Raya L, Juárez J, Pérez J, González I. Effect of Silymarin in Pdx-1 expression and the proliferation of pancreatic β-cells in a pancreatectomy model. Phytomedicine. 2014;21:233. doi:10.1016/j.phymed.2013.09.008

This study investigated how Silymarin affects the growth of insulin-producing cells in a model of partial pancreas removal in rats.

We treated 72 Wistar rats, half of which were given Silymarin daily. The results were clear: the Silymarin-treated rats showed significant increases in both the Pdx1 gene, which is vital for pancreatic health, and insulin production.

Additionally, their β-cell proliferation improved, leading to better blood sugar control. However, the specific effects on pancreatitis were not explored in this study.

Supports digestion

Most Useful Review

I find this supplement essential and take it daily after my pancreatitis attack and gallstones treatment. It's been incredibly helpful.

Rosacea details

Transformed skin appearance

100 people found this helpful

I purchased Silymarin from NOW Foods to support my liver, but it has unexpectedly transformed my face! After suffering from rosacea and constant inflammation, I noticed major improvements in my skin. I no longer need to strictly control my diet; the redness is manageable and my acne has greatly reduced. I’m thrilled I can enjoy sweets and still see positive results. Silymarin has truly worked wonders for me!

Asthma details

Promising anti-inflammatory effects observed

Likely Very Effective

Choi YH, Jin GY, Guo HS, Piao HM, Li Lc, et al. Silibinin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2012;427:450. doi:10.1016/j.bbrc.2012.07.112

We explored the effects of silibinin, a compound from milk thistle, on asthma-related inflammation in a mouse model. By focusing on allergic airway inflammation triggered by ovalbumin, we observed that silibinin significantly decreased inflammatory cell activity and reduced levels of harmful cytokines.

Additionally, silibinin helped prevent airway hyperresponsiveness, showcasing its ability to inhibit a key inflammatory pathway known as NF-κB. These promising results position silibinin as a potential therapeutic option for managing asthma symptoms.

Supports asthma control

Most Useful Review

This supplement is excellent for maintaining healthy liver function and gallbladder health. I recommend it, but one should be cautious about contraindications such as depression, epilepsy, and asthma. It's essential to limit dosages to one to three capsules a day.

Bacterial Infection details

Effective skin improvement

This is my most favourite and effective Silymarin))) Without it, I truly feel like I'm without hands, as I suffer from eczema of the hands. The primary cause of this bacterial infection is my liver and gallbladder issues. Throughout my life, I've endured pain in my right side, nausea, and intestinal disturbances, which worsened after pregnancy, leading to eczema. This supplement is like salvation. The only downside is its occasional unavailability, forcing me to order smaller dosages or from other companies, confirming THIS IS THE BEST! It also enhances my facial skin, cleansing it of bumps, acne, and blackheads, resulting in an even, beautiful, and healthy complexion. Many people often ask which beauty salon I frequented))))

Bone Pain details

Transformed skin condition

100 people found this helpful

I purchased Silymarin for liver support, and it surprisingly transformed my skin. I had struggled with acne for ten years, but since starting Silymarin, I no longer have significant bone pain or inflammation. Now, I can enjoy a varied diet without fear of worsening my complexion. My skin feels great, and I've noticed a reduction in blemishes. I highly recommend this supplement for both liver health and improving skin appearance!

Constipation details

283 people found this helpful

This drug is a fantastic discovery - milk thistle extract with artichoke and dandelion! It's excellent for bile flow. I find that every morning, I take a glass of hot water with one capsule of silymarin. After a month, my digestion has greatly improved, there’s no constipation, and I feel lighter after meals. My skin is now clear without any rashes. I recommend it.

Epilepsy details

Natural ingredient benefits

I'm pleased it's made from all-natural ingredients and I've had no side effects after using it. We use it for my husband's liver health, which has been affected by many years of epilepsy medication.

Gout details

7 people found this helpful

I have been using this supplement for several months to relieve my gout symptoms, which I have struggled with for nearly 30 years. Taken alongside other supplements, it has kept my gout in check. Even during flare-ups, the pain is now minor. Adding Silymarin 2X to my daily routine has significantly improved my ability to manage gout without the usual pain, swelling, and stiffness.

Heartburn details

Heartburn improvement

336 people found this helpful

I absolutely adore this silymarin! After being ill and taking various medications, my husband and I completed a liver support course. We noticed a marked improvement in our overall condition, especially with heartburn and discomfort in the upper abdomen. We would gladly repeat this course if necessary.

Lung Cancer details

Potential NSCLC treatment candidate

Based on 14 Researches

Rugamba A, Kang DY, Sp N, Jo ES, Lee JM, et al. Silibinin Regulates Tumor Progression and Tumorsphere Formation by Suppressing PD-L1 Expression in Non-Small Cell Lung Cancer (NSCLC) Cells. Cells. 2021;10. doi:10.3390/cells10071632

We investigated the potential of silibinin, a natural compound from milk thistle, in treating non-small cell lung cancer (NSCLC). Our study employed various assays to analyze how silibinin impacts cancer cell growth and migration.

We found that silibinin effectively inhibited the growth of NSCLC cells and suppressed important pathways linked to tumor progression. It worked by preventing tumor cells' ability to form new tumors and inhibited the expression of proteins associated with cancer growth.

Overall, silibinin shows promise as a candidate for both tumor immunotherapy and targeting cancer stem cells.

Liver function improvement

Most Useful Review

1 people found this helpful

My sister is undergoing chemotherapy for lung cancer. Her liver enzyme levels increased after starting treatment, but after I suggested this product, her doctor prescribed it too. Now, her liver function is normal, and the chemotherapy is effective for her lung cancer.

Abscess details

Effective hormonal treatment

13 people found this helpful

Okay. A friend recommended this for my acne, which is linked to a serious hormonal imbalance that I manage with varying success. I experience painful subcutaneous acne with periodic abscesses, a complete hormonal mess. After a month of taking this, the results are excellent with much fewer rashes. It's truly a lifesaver, and my doctor has approved the course. The jar is lightweight, plastic, and 90% full, making it convenient to carry.

Anemia details

Questionable

Silymarin shows potential in thalassemia

Gharagozloo M, Moayedi B, Zakerinia M, Hamidi M, Karimi M, et al. Combined therapy of silymarin and desferrioxamine in patients with beta-thalassemia major: a randomized double-blind clinical trial. Fundam Clin Pharmacol. 2009;23:359. doi:10.1111/j.1472-8206.2009.00681.x

We conducted a randomized, double-blind clinical trial to investigate the effects of silymarin on patients with beta-thalassemia major.

Over three months, 59 patients received either silymarin along with desferrioxamine or a placebo.

While silymarin showed promising benefits, particularly in liver and red blood cell health, there was no significant difference in serum ferritin levels between groups after treatment.

However, we believe that this combination can be safely integrated into therapies for iron-overloaded patients.

Boosted energy levels

Most Useful Review

I've just started taking this supplement and was pleasantly surprised by the surge of energy it provides while I tackle my anaemia. My hair had been falling out in clumps for four years, and now I feel more confident while washing and combing it again.

Autoimmune Disorder details

Silybin shows promise for autoimmune disorders

Based on 9 Researches

Yang HL, Shi XW. Silybin Alleviates Experimental Autoimmune Encephalomyelitis by Suppressing Dendritic Cell Activation and Th17 Cell Differentiation. Front Neurol. 2021;12:659678. doi:10.3389/fneur.2021.659678

We investigated how silybin, a unique flavonoid found in certain plants, impacts autoimmune disorders, specifically using a model for multiple sclerosis called experimental autoimmune encephalomyelitis (EAE).

In our study, silybin significantly reduced disease severity, inflammation, and damage to the central nervous system (CNS) in EAE mice.

The findings suggest that silybin works by inhibiting the activation of dendritic cells and reducing harmful Th17 cell differentiation. This positions silybin as a promising candidate for new treatments aimed at autoimmune diseases like multiple sclerosis.

Transformed my skin

Most Useful Review

100 people found this helpful

I bought silymarin for liver support and unexpectedly, it transformed my face! After years of acne, my skin improved significantly. I can now indulge occasionally without suffering from outbreaks. Highly recommended for both liver and skin health!

Back Pain details

212 people found this helpful

I had to delve deeply! The liver is crucial for the body's functioning, acting as a toxin filter and assisting in nutrient absorption. Unfortunately, alcohol and junk food harm it. Thankfully, my liver began to heal. I took Silymarin, which alleviated my back pain while I maintained my diet. If you find this review helpful, please respond with YES.

Bulimia details

Mental and energy boost

I’ve been using this supplement for the past month with notable positive effects. It's not just physical; my mental clarity has increased, and my energy levels are consistent. The quality formula uses natural ingredients and is easy to integrate into my routine—there's no aftertaste or side effects. I highly recommend this for anyone seeking to improve their health and well-being, as it has made a significant difference for me.

Chemotherapy details

Liver function improved

The doctor prescribed the same treatment. My sister is on chemotherapy for lung cancer, and her liver enzyme levels increased after starting. I assured her that this would help protect her liver and lower the enzyme levels. After several blood tests, her oncology doctor also prescribed the same medication for daily use. Her liver function returned to normal, and chemotherapy is working effectively for her lung cancer.

Migraine details

YES! This works! Whenever I have a migraine due to indulging in brownies and sugar, I take this and it alleviates my migraine for sure. It detoxifies the liver.

Pneumonia details

Inhalable silymarin shows promise

Hanafy NAN, El-Kemary MA. Silymarin/curcumin loaded albumin nanoparticles coated by chitosan as muco-inhalable delivery system observing anti-inflammatory and anti COVID-19 characterizations in oleic acid triggered lung injury and in vitro COVID-19 experiment. Int J Biol Macromol. 2022;198:101. doi:10.1016/j.ijbiomac.2021.12.073

We explored the potential of a new inhalable delivery system packed with silymarin and curcumin for treating lung inflammation caused by COVID-19. Through our research, we observed a significant reduction in key inflammatory markers in those treated with our formulated nanoparticles compared to control groups.

Furthermore, our study showed improved tissue profiles, indicating enhanced lung health. Additionally, silymarin demonstrated antiviral properties in laboratory tests against COVID-19. Overall, this innovative treatment approach could help address inflammation and improve recovery in respiratory conditions.

7.5

Improved skin condition

Most Useful Review

14 people found this helpful

My husband, aged 68, has taken cholesterol medication for over 10 years and was diagnosed with pneumonia five months ago. After two to three months, red bumps appeared on his skin and spread to his back. He did not want to see a doctor, so I purchased this product. After taking two capsules daily for a few days, I noticed improvement. The previous discolouration has faded, and we hope to continue using it for further benefits. 💪💪

Ulcer details

Silybin nanoparticles reduce ulcer markers

Based on 5 Researches

Varshosaz J, Minaiyan M, Khaleghi N. Eudragit nanoparticles loaded with silybin: a detailed study of preparation, freeze-drying condition and in vitro/in vivo evaluation. J Microencapsul. 2015;32:211. doi:10.3109/02652048.2014.995728

We investigated the use of silybin nanoparticles in treating ulcerative colitis (UC). These nanoparticles were carefully prepared and tested in a rat model, where UC was induced with acetic acid.

Over five days, we compared the effects of silybin nanoparticles with other treatments. The results showed significant improvements in both macroscopic and histopathological evaluations.

Notably, levels of harmful markers such as TNF-α and IL-6 were reduced, highlighting the potential benefit of silybin nanoparticles in ulcer treatment.

Ulcer healing support

Most Useful Review

I recommend it; it enhances the functioning of my intestines and pancreas, aids in detoxifying the body, speeds up metabolism, normalises appetite, and helps heal ulcers.

Anxiety details

Silibinin shows promise for anxiety

Based on 4 Researches

Liu X, Chen W, Wang C, Liu W, Hayashi T, et al. Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation. Physiol Behav. 2021;241:113593. doi:10.1016/j.physbeh.2021.113593

We explored how silibinin, a compound from the Silybum marianum plant, might alleviate anxiety and depression in a mouse model of Parkinson's disease. Using various behavioral tests, we found that silibinin treatment significantly reduced anxiety-like behaviors while also improving the condition of hippocampal neurons.

Additionally, it restored levels of key mood-regulating neurotransmitters. By lowering markers of neuroinflammation, silibinin showed promise as a potential treatment for anxiety and depression associated with Parkinson's disease.

Reduced anxiety symptoms

Most Useful Review

1 people found this helpful

This is my third bottle. I take it to support my liver and I've found it helps significantly with anxiety during parties. A couple of capsules in the morning helps me manage anxiety, which I previously couldn't overcome without beer.

Bloating details

221 people found this helpful

This drug has enhanced my gastrointestinal health. My digestion has improved, bloating has subsided, and my stool is now regular.

Cardiovascular Disease details

SM reduces cardiac triglyceride levels

Based on 11 Researches

Vilahur G, Sutelman P, Mendieta G, Ben-Aicha S, Borrell-Pages M, et al. Triglyceride-induced cardiac lipotoxicity is mitigated by Silybum marianum. Atherosclerosis. 2021;324:91. doi:10.1016/j.atherosclerosis.2021.03.014

We examined the effects of Silybum marianum (SM) on heart health through a study on pigs with myocardial infarction. Our findings revealed that administering SM for ten days significantly lowered plasma triglycerides and reduced triglyceride absorption.

Notably, this outcome correlated with reduced cardiac lipotoxicity three weeks after the heart incident and better cardiac structure. Importantly, we observed no adverse effects from SM. Overall, while SM shows promise in improving certain heart conditions, further research could clarify its broader application.

Improves liver function

Most Useful Review

3 people found this helpful

I ordered this herb to support my liver. Following dietary recommendations, I began to heal, and my liver's fatty condition improved. My lab results show normal levels after just one year of consistent milk thistle intake.

Chest Pain details

361 people found this helpful

Oops! I absolutely adore MILK THISTLE! It has 80% silymarin, which works wonders. After just one dose, the chest pain in my right side disappeared! Taking it with breakfast seems best as it aids bile production without irritating the gastrointestinal tract. Research supports silymarin's protective effects on liver cells and its ability to reduce liver inflammation. I have fatty hepatosis and decided to help my liver recover. This brand is effective and quick-acting. Highly recommended! Wishing everyone good health!

Floaters details

I have been taking this supplement for quite some time, and it appears to lessen the intensity of my floaters.

Frozen Shoulder details

Stiff shoulders relief

I suffered from chronic, stiff shoulders without pain. Since taking this supplement, my muscles have softened, and I've felt better within a month. However, after taking three pills daily, I experienced chest pain, so I reduced to one pill a day, which alleviated the pain.

Heart Disease details

2,3-dehydrosilybin shows heart protection

Based on 8 Researches

Gabrielová E, Bartošíková L, Nečas J, Modrianský M. Cardioprotective effect of 2,3-dehydrosilybin preconditioning in isolated rat heart. Fitoterapia. 2019;132:12. doi:10.1016/j.fitote.2018.10.028

We investigated the potential heart health benefits of 2,3-dehydrosilybin (DHS), a component of silybum marianum. In our study, rats' isolated hearts were treated with low doses of DHS before experiencing induced heart attacks and subsequent recovery.

The results showed that DHS significantly reduced heart tissue damage compared to untreated hearts, suggesting it has a protective effect. This effect is linked to specific signaling pathways in the heart. Overall, our research highlights the promising cardioprotective properties of this natural compound.

Liver health boost

Most Useful Review

6 people found this helpful

I prescribe Silymarin for my patients to support liver function, especially after examinations. It is effective for reducing cholesterol and treating various liver conditions. The biochemical parameters improve significantly, and it can help those with heart disease. Following a proper diet and dosage is essential for best results.

Hot Flashes details

20 people found this helpful

Good quality supplement that promotes bile flow effectively. Milk thistle acts as a liver healer, aiding in detox and absorption benefits. I've experienced a pleasant lightness in my stomach after using it. The plant-based ingredients are a major plus. Convenient packaging and good taste make it easy to take. It appears to have a beneficial dosage and positively affects skin conditions, assisting in various skin inflammations and cleansing the blood. According to studies, milk thistle reduces the frequency and severity of hot flashes during menopause.

Kidney Stones details

Restored liver function

24 people found this helpful

I had a swollen liver and gallbladder issues. After taking various herbs, including Now Foods' Silymarin, my liver size significantly reduced in days. My chronic backache vanished, and my energy improved considerably. I can now eat peanuts without adverse reactions, which I use to gauge my liver health. Silymarin has truly helped restore my liver function.

Leg Cramps details

21 people found this helpful

Excellent Silymarin! I've been taking this extra strength silymarin to assist with detoxing from oestrogens and other toxins I encounter daily. I found that if I take it daily for 1-2 weeks before my menstrual cycle, I experience no PMS or leg cramps! I’ll continue using this silymarin as long as NOW produces it.

Pelvic Pain details

361 people found this helpful

Oops! How I love Milk Thistle! With 80% silymarin, it works wonders! After just one dose, the pelvic pain disappeared! I take it during breakfast, as it aids in bile production. Research supports silymarin's benefits for liver cell protection against toxins and inflammation. I have fatty hepatosis and feel the brand is effective. I strongly recommend this high-quality product for liver health!

Polycystic Ovary Syndrome details

212 people found this helpful

Today, many are overly invested in their health, purchasing numerous supplements like Omega-3 and various vitamins. Yet, few realise that a functioning gastrointestinal tract is crucial for nutrient absorption. With poor dietary habits, many have unhealthy livers, causing issues that may manifest as acne. Having Polycystic ovary syndrome (PCOS), I underwent antiandrogenic therapy, which highlighted the liver's role in hormone regulation. After adjusting my nutrition and taking Milk Thistle for three months, the acne on my cheekbones gradually faded. Other supplements only showed their benefits after cleansing my liver. For effectiveness, it’s vital to take one capsule 20 minutes after meals. If you find this useful, please click "YES" 😊.

Psoriasis details

Milk thistle shows anti-psoriatic effects

Kamel NM, El-Sayed SS, El-Said YAM, El-Kersh DM, Hashem MM, et al. Unlocking milk thistle's anti-psoriatic potential in mice: Targeting PI3K/AKT/mTOR and KEAP1/NRF2/NF-κB pathways to modulate inflammation and oxidative stress. Int Immunopharmacol. 2024;139:112781. doi:10.1016/j.intimp.2024.112781

We investigated how milk thistle extract might help treat psoriasis in mice. Our study involved forty Swiss albino mice divided into four groups, including a test group treated with the milk thistle extract after inducing psoriasis with imiquimod.

The results were encouraging, showing that the extract significantly reduced skin symptoms like redness and scaling, similar to traditional cortisone treatments. It worked by inhibiting specific cellular pathways, reducing inflammation and boosting antioxidant defenses, suggesting that milk thistle could be an effective new option for psoriasis treatment.

Mild psoriasis improvement

Most Useful Review

33 people found this helpful

Silymarin Milk Thistle has been a game-changer for me. After three weeks, my mild psoriasis is almost gone. I noticed an immediate boost in my energy from the first tablet and have even started giving it to my son with similar positive results.

Arthritis details

Silymarin shows anti-arthritis potential

Based on 5 Researches

Gupta OP, Sing S, Bani S, Sharma N, Malhotra S, et al. Anti-inflammatory and anti-arthritic activities of silymarin acting through inhibition of 5-lipoxygenase. Phytomedicine. 2000;7:21.

We evaluated the anti-inflammatory and anti-arthritic properties of silymarin, derived from the Silybum marianum plant. In our study, we found that silymarin significantly reduced inflammation and arthritis symptoms in rat models. The research suggests that this effect occurs through the inhibition of a specific enzyme, 5-lipoxygenase.

While these results showcase the potential of silymarin, it's important to note that further research is needed to fully understand its effectiveness in humans.

7.5

Reduced pain effectively

Most Useful Review

8 people found this helpful

Working. I have to take various supplements and medications due to arthritis. It's tough on my liver, but after a week of this product, I noticed a reduction in both weight and pain. I recommend it.

Blood Clot details

Flavonolignans reduce platelet activity

Bijak M, Saluk-Bijak J. Flavonolignans inhibit the arachidonic acid pathway in blood platelets. BMC Complement Altern Med. 2017;17:396. doi:10.1186/s12906-017-1897-7

We aimed to explore how flavonolignans from silybum marianum, specifically silybin, silychristin, and silydianin, affect blood clotting through the COX pathway in platelets. Our methods involved analyzing platelet aggregation and the formation of COX pathway metabolites.

The findings were promising; these compounds showed a reduction in platelet aggregation and COX activity. Silychristin and silybin emerged as the most effective inhibitors, potentially acting as competitive blockers at the active COX site. This suggests that flavonolignans might offer new avenues for antiplatelet and anti-inflammatory therapies.

7.5

Fatty liver treatment

Most Useful Review

8 people found this helpful

My liver was in a poor state due to fatty liver. After taking this, my blood test results returned to normal values. I don't feel the effects, but the data shows improvement. I took one after breakfast and dinner.

Depression details

Silibinin reduces depression in mice

Based on 8 Researches

We investigated the impact of silibinin, a natural compound from Silybum marianum, on depression and anxiety in mice with Parkinson's disease. Through various behavioral tests, we found that silibinin significantly reduced depressive and anxious behaviors caused by MPTP, a chemical used to induce these symptoms.

Additionally, silibinin helped repair neuronal damage in the hippocampus and restored levels of important mood-regulating neurotransmitters. It also reduced markers of neuroinflammation linked to depression, suggesting silibinin may hold promise as a treatment for these conditions in Parkinson's.

7.5

Improved well-being

Most Useful Review

1 people found this helpful

I really like this company, as the quality is good. My liver feels better with this product after a month. However, if I stop using it, I experience issues again. Milk Thistle has effects beyond liver health; it aids in tissue repair and even depression. I will continue taking this supplement.

Hemorrhoids details

Hemorrhoids improvement

I adore supplements with milk thistle as they heal liver cells and cleanse the body, removing toxins. Unexpectedly, my hemorrhoids disappeared while taking it. The dandelion root is known for its beneficial properties, and artichoke aids in cleansing the liver, forming bile, and processing fats. I take a capsule at night, as it supports the gallbladder and liver functions. I am pleased with the results.

High Cholesterol details

Silymarin positively influences cholesterol

Ebrahimpour-Koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-Jafarabadi M. Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. (silymarin) extract supplement: A Triple-blinded randomized controlled clinical trial. Phytomedicine. 2018;44:39. doi:10.1016/j.phymed.2018.03.050

We conducted a triple-blinded randomized clinical trial with 40 type 2 diabetes patients to see how silymarin impacts cholesterol and blood sugar levels. Over 45 days, participants received either silymarin or a placebo.

Our findings showed that those taking silymarin experienced significant improvements. They had lower fasting blood sugar, reduced triglycerides, and improved levels of good HDL cholesterol.

However, while the results are promising, further research is necessary to confirm these benefits for managing cholesterol in diabetes patients.

Improved liver function

Most Useful Review

145 people found this helpful

Milk thistle is excellent for high liver enzymes. After being diagnosed with fatty liver, I took this supplement and immediately noticed a reduction in abdominal bloating and discomfort. Six months later, my liver function tests are nearly normal. I feel progressively better with no side effects.

Insomnia details

Alleviated insomnia symptoms

I felt terrible with spinal and joint pain, high blood pressure, and insomnia, which led to fatigue and depression. After taking magnesium, I noticed a boost in energy and began to regain my sense of purpose.

Liver Disease details

Silymarin improves liver protection

Okiljević B, Martić N, Govedarica S, Andrejić Višnjić B, Bosanac M, et al. Cardioprotective and Hepatoprotective Potential of Silymarin in Paracetamol-Induced Oxidative Stress. Pharmaceutics. 2024;16. doi:10.3390/pharmaceutics16040520

We investigated the effects of silymarin on liver and heart health under oxidative stress from paracetamol. In a controlled study with 28 male mice, silymarin showed a strong potential to reduce liver injury markers and improve liver enzyme levels after treatment.

Histopathological assessments revealed less tissue damage and inflammation in mice treated with silymarin compared to those that only received paracetamol. Overall, these findings demonstrate that silymarin is a promising option to help protect the liver and heart from oxidative stress-related injury.

7.5

Liver recovery observed

Most Useful Review

1382 people found this helpful

Recently, I discovered that I have liver disease after tests revealed high enzyme levels. In a panic, I researched and learned that the liver has remarkable self-restorative abilities. I started a diet and looked into dietary supplements, purchasing one containing milk thistle and artichoke extract. Although I can't be certain of its specific effects, my tests returned to normal after a month. I recommend looking into these supplements for liver support.

Menopause details

Effective herbal treatment for menopause

Based on 4 Researches

Saberi Z, Gorji N, Memariani Z, Moeini R, Shirafkan H, et al. Evaluation of the effect of Silybum marianum extract on menopausal symptoms: A randomized, double-blind placebo-controlled trial. Phytother Res. 2020;34:3359. doi:10.1002/ptr.6789

We evaluated the effects of Silybum marianum, a herbal remedy, on menopausal symptoms, particularly hot flashes. In a well-structured study with eighty women, half were given S. marianum extract while the other half received a placebo over 12 weeks.

Remarkably, the group taking Silybum saw a significant drop in the frequency and severity of hot flashes. Their scores on relevant scales improved notably compared to those on placebo.

This suggests that Silybum marianum could be an effective option for managing menopausal symptoms, making it a promising choice for women seeking relief.

Post-menopause refreshment

Most Useful Review

2 people found this helpful

Excellent! During menopause, I noticed my liver function declined. Drinking this before bed has me feeling refreshed in the mornings. I would like to continue using it for a while longer.

Nausea details

81 people found this helpful

Set to 10 stars! This is my absolute favourite supplement for treating my nausea caused by eczema related to liver issues. After using it, I noticed a significant improvement in my skin. My only complaint is that it's often unavailable, but its effectiveness is worth ordering in lower dosages or from another brand.

Gastritis details

Excellent! This drug is quite comfortable, and I recommend it to anyone who cares for their health. I have gastritis, but I have no adverse effects and my stomach tolerates it well. I bought a larger jar for a 3-month course. This should benefit anyone looking to improve liver health.

Osteoporosis details

Promising silibinin effects on osteoporosis

Based on 5 Researches

Kim JL, Kang SW, Kang MK, Gong JH, Lee ES, et al. Osteoblastogenesis and osteoprotection enhanced by flavonolignan silibinin in osteoblasts and osteoclasts. J Cell Biochem. 2012;113:247. doi:10.1002/jcb.23351

In our exploration, we found that silibinin, a key component of silymarin derived from milk thistle, shows promising effects on osteoporosis treatment. Through in vitro studies involving murine osteoblast and macrophage cells, silibinin not only boosted bone formation by promoting the growth and mineralization of bone cells but also helped inhibit the harmful activity of osteoclasts, which are responsible for bone resorption.

Although these findings are encouraging, it’s essential to note that further research is needed to confirm its efficacy and potential for use in clinical settings.

Improves liver function

Most Useful Review

My doctor recommended silymarin to protect and restore my liver. After using 100 capsules, my liver function improved significantly, and my acne cleared up. This is likely the best silymarin available; I will order more for my parents to support their osteoporosis prevention.

Prostate Cancer details

Supports liver function

5 people found this helpful

Milk thistle seeds contain silymarin, a polyphenol known for its excellent effects, including anti-cancer properties and liver function improvement. Additionally, it normalises blood sugar, acts as an antioxidant, and lowers LDL cholesterol. With 100mg of dandelion root and 50mg of artichoke leaves, it’s the perfect combination. Now, I need not take them separately, making it the best value for money. This product may be a saviour for those who enjoy alcohol. Each tablet contains 240mg of silymarin, vital for supporting liver health.

Rash details

Rapid rash improvement

275 people found this helpful

The third saviour for atopic dermatitis! Despite my cholecystitis and longstanding allergies since age 5, my liver function has remained normal. After three months of this dietary supplement, I found that my allergic rash disappears quickly, especially with dietary errors. While I've tried various other products, California Gold Nutrition stands out. My body clearly prefers this remedy. Overall, my neurodermatitis has improved significantly!

Reflux details

Reduced reflux symptoms

I really liked this dietary supplement with milk thistle. My bile reflux has stopped, resulting in no more discomfort in my stomach after eating. It has helped cleanse my liver and normalise bile flow. I plan to continue taking it.

Candidiasis details

Taking this has worked wonderfully for me as it cleanses the liver, especially when doing a detox diet to eliminate Candida overgrowth. It has also helped alleviate my constipation and eliminated toxins from my body—highly recommended and easy to swallow.

Cholecystitis details

141 people found this helpful

SILIMARINE is crucial for liver support! During my ultrasound, the doctor indicated mild obesity of the liver. This compelled me to consider liver health seriously. Despite being of normal weight, I acted quickly to support the liver, reading reviews and eventually purchasing silymarin. It’s my second order and maintaining liver health is a necessity. Milk thistle seeds contain valuable components like silymarin, which enhances metabolism and combats toxins. I'm currently taking two capsules daily and feel much lighter. The results have been positive, and I plan to continue using silymarin regularly.

Chronic Cough details

10 people found this helpful

Super Silymarin (Milk Thistle), recognised for centuries, may aid liver function. I take it due to chronic liver disease and gall bladder issues, combined with dandelion and artichoke, which enhance its effects. I also grind milk thistle seeds, adding them to my regimen.

Heart Attack details

2,3-Dehydrosilybin aids heart protection

Based on 3 Researches

We investigated the effects of 2,3-dehydrosilybin, a component of silybum marianum, on heart protection during ischemia and reperfusion injuries in rats. Hearts treated with low doses of this compound experienced significantly reduced damage compared to untreated ones—only about 7.5% of the heart was affected versus over 75% in controls.

This suggests that silybum marianum could effectively support heart health by minimizing injury during heart attacks. Importantly, when specific kinases were inhibited, this protective effect vanished, highlighting the complexity of the mechanisms involved.

Heart health boost

Most Useful Review

The quality is high with excellent ingredients, beneficial for heart health. The wild squill is sealed and the quantity is ideal. I am very satisfied with this product.

Hypertension details

Silybine lowers blood pressure in rats

Based on 3 Researches

Lecomte J. [General pharmacologic properties of silybine and silymarine in the rat]. Arch Int Pharmacodyn Ther. 1975;214:165.

We examined how silybine, the active ingredient in Silybum marianum, impacts blood pressure based on research conducted on normal albino rats. We found that even at low doses, silybine effectively lowers systemic blood pressure without causing increased vascular permeability.

Interestingly, it also helps counteract anaphylactic shocks and stabilize cell membranes, preventing histamine release. However, further studies are needed to fully understand its potential effects on hypertension in humans.

7.5

Blood pressure stabilised

Most Useful Review

I purchased this because of reviews suggesting it can improve hypertension and diabetes. I've only just started taking it, but my blood pressure has stabilised. I'm eager for my next appointment.

Swollen Lymph Nodes details

Significant liver improvement

24 people found this helpful

I previously had a swollen liver and backed up gallbladder. After taking various herbs, including Herb Pharm's Stone Breaker, and Now Foods' Silymarin, I noticed significant changes. My gallbladder issues reduced substantially in just a few days. My swollen liver, which persisted for months, greatly decreased, and my energy levels improved by about 30%. I can now eat peanuts without experiencing breakouts, which I use as a test for my liver's condition.

Irritable Bowel Syndrome details

Effective supplement for IBS relief

Di Pierro F, Putignano P, Villanova N. Retrospective analysis of the effects of a highly standardized mixture of Berberis aristata, Silybum marianum, and monacolins K and KA in diabetic patients with dyslipidemia. Acta Biomed. 2018;88:462. doi:10.23750/abm.v88i4.5851

We explored the effects of a supplement called Berberol®K, which contains silybum marianum, on patients dealing with irritable bowel syndrome (IBS) alongside diabetes and dyslipidemia.

In a retrospective study with 59 subjects, those who were treated showed notable improvements after six months, including reduced diarrhea symptoms.

The results suggest that this food supplement could be beneficial, especially for those who cannot tolerate standard treatments like statins.

Digestive health

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6 people found this helpful

I've suffered from severe digestive problems for ages, but this milk thistle has transformed my gut health. My bowel movements are now consistent, and constipation is no longer an issue. The quality is exceptional, and the capsules are easy to swallow.

Breast Cancer details

Silibinin enhances apoptosis in cancer

Pirouzpanah MB, Sabzichi M, Pirouzpanah S, Chavoshi H, Samadi N. Silibilin-induces apoptosis in breast cancer cells by modulating p53, p21, Bak and Bcl-XL pathways. Asian Pac J Cancer Prev. 2015;16:2087.

We explored the effects of silibinin, a natural flavonoid, on MCF7 breast cancer cells to assess its potential as a treatment option. Using flow cytometry, we discovered that silibinin significantly inhibits cell growth and induces apoptosis in a dose-dependent manner after 24 hours of treatment.

Notably, the study found increased expression of important genes related to apoptosis and cancer suppression, suggesting that silibinin could enhance the effectiveness of traditional chemotherapy. Its low side effects make it an appealing candidate for further research in cancer therapy.

Liver function normalised

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1 people found this helpful

The doctor prescribed the same treatment. My sister, undergoing chemotherapy for breast cancer, had elevated liver enzyme levels after starting her treatment. I informed her this would protect her liver and lower those levels. Eventually, her oncology doctor also prescribed it for her daily use. Her liver function returned to normal and the chemotherapy has been effective for her breast cancer.

Cancer details

Investigating silibinin's cancer treatment role

Li P, Wang D, Yang X, Liu C, Li X, et al. Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification. Molecules. 2024;29. doi:10.3390/molecules29081901

We aimed to uncover how silibinin, a compound from milk thistle, impacts cancer, specifically in adenoid cystic carcinoma cells and Balb/c nude mice. The study identified 75 key targets linked to tumor growth and showcased that silibinin significantly reduced cell viability, proliferation, and migration.

Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.

Natural hepatoprotector

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18 people found this helpful

Silymarin, derived from milk thistle, is a non-toxic natural substance known for its hepatoprotective and antioxidant properties. It exhibits anti-cancer effects, improves liver function, and has been extensively studied in over 3,000 scientific papers. Its zero toxicity has been noted in various clinical studies.

Chronic Fatigue Syndrome details

70 people found this helpful

This product has become a staple for managing my chronic fatigue syndrome. Taking 300mg twice daily energises me and reduces tiredness significantly. I'm delighted with the results and enjoy taking this alongside my favourite drinks.

Obesity details

Kim S, You Y, Kim OK, Lee J, Chung JW, et al. Silymarin Prevents High-Fat Diet-Induced Muscle Atrophy by Regulating Protein Degradation and Synthesis in Mice. J Med Food. 2022;25:793. doi:10.1089/jmf.2021.K.0175

Based on 8 Researches

Silymarin reduces obesity effects

We explored how silymarin helps with obesity and muscle atrophy in mice. In our study, we divided the mice into three groups: a control group on a normal diet, another group on a high-fat diet, and a third group receiving silymarin alongside the high-fat diet.

The results showed that the silymarin group had less weight gain and maintained better muscle mass compared to the high-fat diet group. Moreover, the grip strength of the mice on silymarin improved. Overall, silymarin seems beneficial for not only tackling obesity but also preserving muscle health.

Enhanced energy levels

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6 people found this helpful

Initially sceptical, I found Silymarin effective for my fatty liver caused by obesity. Within two weeks, my GGT levels decreased by 20, and I feel significantly better—more energetic and free from heartburn. I’m pleased with the results from taking two capsules daily.

Acne details

Silybum marianum reduces acne severity

Based on 3 Researches

Fontao F, von Engelbrechten M, Seilaz C, Sorg O, Saurat JH. Microcomedones in non-lesional acne prone skin New orientations on comedogenesis and its prevention. J Eur Acad Dermatol Venereol. 2020;34:357. doi:10.1111/jdv.15926

We explored the effects of Silybum marianum fruit extract on acne treatment using a topical formulation over 48 weeks in a group of acne patients. The study identified microcomedones, which are early signs of future acne lesions, as a target for prevention.

Our findings revealed that using the extract significantly lowered the microcomedone index in patients, indicating a reduction in acne severity. The improvement in microcomedones closely tied to a decrease in clinical lesions suggests that Silybum marianum may be a promising option for maintaining clearer skin and preventing future breakouts.

Effective for acne

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189 people found this helpful

I'm amazed! After years of battling acne linked to sugar and hormones, I discovered that liver health affects skin. I began taking milk thistle, which lowered my blood sugar and supported my liver. Within a week, my skin improved immensely and I could enjoy sweets without suffering breakouts.

Diabetes details

Silibinin shows potential for diabetes

Zare Mehrjerdi P, Asadi S, Ehsani E, Askari VR, Baradaran Rahimi V. Silibinin as a major component of milk thistle seed provides promising influences against diabetes and its complications: a systematic review. Naunyn Schmiedebergs Arch Pharmacol. 2024;397:7531. doi:10.1007/s00210-024-03172-x

We explored the effects of silibinin, a key component from milk thistle, on diabetes through various studies. The systematic review covered data from multiple databases and highlighted that silibinin can help lower blood glucose levels, reduce insulin resistance, and improve inflammatory responses.

It also showed promise in tackling diabetes complications like liver damage and neuropathy. Despite these encouraging results, it's important to note that further well-structured studies are needed to fully understand how silibinin works in managing diabetes effectively.

Aids liver recovery

Most Useful Review

3 people found this helpful

After being diagnosed with a fatty liver due to type 2 diabetes, I discovered milk thistle extract worked wonders. Since using it daily, my liver discomfort has significantly decreased, which has been a relief.

Headache details

No more chronic fatigue

5 people found this helpful

I used to suffer from chronic fatigue in the mornings, but after taking this product, I felt refreshed, and my headaches disappeared. I highly recommend it for anyone dealing with similar issues.

Common Cold details

If I take this at the onset of a common cold, I usually feel better. It has become my regular medicine.

Indigestion details

No indigestion issues

5 people found this helpful

I really like this brand of milk thistle as it doesn't give me indigestion like some cheaper store brands do. It includes dandelion root, which is beneficial for liver health.

Yeast Infection details

Yun DG, Lee DG. Silibinin triggers yeast apoptosis related to mitochondrial Ca influx in Candida albicans. Int J Biochem Cell Biol. 2016;80:1. doi:10.1016/j.biocel.2016.09.008

Silibinin induces yeast apoptosis

We explored how silibinin, derived from the milk thistle plant, affects Candida albicans, the yeast that can lead to infections. Our research demonstrated that silibinin treatment significantly increased reactive oxygen species, triggering a cascade of events that caused yeast cell death, or apoptosis. Notably, we observed that mitochondrial calcium overload plays a vital role in this process. While silibinin shows promise for combating yeast infections, our findings highlight the importance of further research to fully understand its potential and mechanisms.

Effective liver support

Most Useful Review

1 people found this helpful

After a coronavirus infection, my liver function tests showed elevated levels. I took this product, two capsules a day for two months, and my blood samples returned to normal. This excellent plant-based drug provides great liver support.

Allergies details

Choi YH, Jin GY, Guo HS, Piao HM, Li Lc, et al. Silibinin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2012;427:450. doi:10.1016/j.bbrc.2012.07.112

Based on 4 Researches

Silibinin shows promise for asthma

We examined how silibinin, a compound found in milk thistle, affects allergic asthma in a mouse model. Our findings showed that silibinin significantly helped reduce airway inflammation and hyperresponsiveness, mainly by targeting the NF-κB pathway. This suggests that silibinin might offer protective benefits against allergic airway conditions by moderating inflammatory responses. While our research found promising results in mice, further studies are necessary to confirm its effectiveness in human asthma treatment.

Effective support

Most Useful Review

64 people found this helpful

My husband suffered from seasonal allergies each spring, with watery and itchy eyes, and a runny nose. Over-the-counter antihistamines did nothing. Following a recommendation, I took a liver support regimen before the flowering season began, including silymarin and quercetin, alongside an antihistamine diet. It worked! Supporting the liver is crucial in managing allergies.

Uterine Fibroids details

I purchased it due to claims that it benefits the liver, but I didn’t consume it because it was said to potentially promote Uterine Fibroids.

Whooping Cough details

I used to take COCs, which affected my liver. After researching, I found silymarin on iHerb and began using double-strength capsules. This summer, while combating allergies alongside licorice extract, I surprisingly managed without antihistamines, experiencing no nasal congestion, cough, or eye irritation. I highly recommend silymarin, both on its own and in combination with other treatments for allergies.

Dizziness details

4 people found this helpful

I’ve taken this supplement multiple times without side effects. Silymarin serves well to remove liver toxins, and after a month, my heartburn faded along with skin improvements.

Diarrhea details

Questionable