Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 34 Researches
7.8
USERS' SCORE
Good
Based on 22 Reviews
8.6
Supplement Facts
Serving Size: One (1) Capsule
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%**
Total Sugars
0 g
†
Incl. 0 g Added Sugars
0%**
Intelliflora™ Blend:
150 mg5 billion CFUs
Lactobacillus crispatus LBV 88
†
Lactobacillus rhamnosus LBV 96
†
Lactobacillus gasseri LBV 150N
†
Lactobacillus jensenii LBV 116
†
Top Medical Research Studies
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
8
Lactobacillus shows promise for constipation
We investigated the effects of a new microbial strain, LP-HFY11, on constipation caused by a common medication in mice. The results showed that LP-HFY11 helped maintain fecal weight and improved gut movement. Those given a high dose expelled stool faster than others treated with lactulose, although still slower than in normal mice.
Interestingly, LP-HFY11 also promoted positive changes in intestinal health and increased certain beneficial substances in the bloodstream, suggesting it could serve as an effective probiotic for constipation management. There appears to be promising potential for LP-HFY11's use in both the food and pharmaceutical industries.
Interestingly, LP-HFY11 also promoted positive changes in intestinal health and increased certain beneficial substances in the bloodstream, suggesting it could serve as an effective probiotic for constipation management. There appears to be promising potential for LP-HFY11's use in both the food and pharmaceutical industries.
Read More
7
Lactobacillus gasseri alleviates constipation symptoms
We conducted a comprehensive study to determine how Lactobacillus gasseri impacts chronic constipation. The clinical trial involved 40 women who were given either Lactobacillus gasseri or a placebo over a 28-day period.
Our findings revealed that this probiotic strain significantly reduced abdominal pain and suggested an increase in complete spontaneous bowel movements. While the results are promising, we did not observe a major breakthrough in bowel function improvement.
Overall, Lactobacillus gasseri may help relieve some symptoms associated with functional constipation.
Our findings revealed that this probiotic strain significantly reduced abdominal pain and suggested an increase in complete spontaneous bowel movements. While the results are promising, we did not observe a major breakthrough in bowel function improvement.
Overall, Lactobacillus gasseri may help relieve some symptoms associated with functional constipation.
Read More
Most Useful Reviews
9.5
Pregnancy relief
This product transformed my pregnancy! After experiencing two yeast infections early on, I started taking these and haven't had any issues since! Additionally, I haven’t suffered from constipation. I highly recommend it to everyone who is pregnant!
Read More
8.8
Helps with smell
I’ve been taking this product for about a week, and it has significantly helped me. The unpleasant smell I've had for months has disappeared. Although it caused slight constipation, this supplement is essential for me. Ingredients are safe, and it’s easy to consume.
Read More
9.5
Eases constipation
This daily probiotic supplement efficiently eases my occasional constipation and improves my digestive system’s health.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 34 Researches
7.8
- All Researches
9
We explored the potential of the probiotic CCFM1163 to alleviate slow-transit constipation caused by prolonged laxative use, known as cathartic colon. Using a mouse model, we observed how this probiotic affects the gut's nerve and barrier functions.
The findings revealed that CCFM1163 enhances the expression of brain-derived neurotrophic factor (BDNF), which activates a key signaling pathway, helping to restore gut health. As a result, it significantly improved intestinal function, offering hope for those suffering from this condition.
The findings revealed that CCFM1163 enhances the expression of brain-derived neurotrophic factor (BDNF), which activates a key signaling pathway, helping to restore gut health. As a result, it significantly improved intestinal function, offering hope for those suffering from this condition.
Read More
9
Probiotics effectively relieve constipation
We explored how specific microbial agents can change the gut bacteria and help relieve constipation in mice. The study focused on two treatments, including Lactobacillus, and found they increased beneficial gut bacteria and improved peristalsis, which is the movement that helps waste pass through the intestines.
Notably, one agent, PE0401, showed a better ability to alleviate constipation symptoms by enhancing gut health and reducing inflammation. The results suggest that probiotics can play a positive role in managing constipation.
Notably, one agent, PE0401, showed a better ability to alleviate constipation symptoms by enhancing gut health and reducing inflammation. The results suggest that probiotics can play a positive role in managing constipation.
Read More
9
Lactobacillus reduces constipation symptoms
We explored the effects of a fermented milk product containing two specific probiotic strains, Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1, on relieving constipation in mice.
Over 14 days, we found that this probiotic mix enhanced gastrointestinal function by boosting the secretion of important gut hormones and increasing beneficial bacteria while reducing harmful ones.
Our findings suggest this fermented milk could be a useful approach to managing constipation and improving gut health.
Over 14 days, we found that this probiotic mix enhanced gastrointestinal function by boosting the secretion of important gut hormones and increasing beneficial bacteria while reducing harmful ones.
Our findings suggest this fermented milk could be a useful approach to managing constipation and improving gut health.
Read More
9
We investigated the effects of Lactobacillus rhamnosus (LRJ-1) on constipation in mice. The study revealed that oral treatment with LRJ-1 led to significant improvements in constipation by increasing levels of a gut compound called γ-aminobutyric acid (GABA).
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
Read More
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
User Reviews
USERS' SCORE
Good
Based on 22 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Pregnancy relief
This product transformed my pregnancy! After experiencing two yeast infections early on, I started taking these and haven't had any issues since! Additionally, I haven’t suffered from constipation. I highly recommend it to everyone who is pregnant!
Read More
8.8
Helps with smell
I’ve been taking this product for about a week, and it has significantly helped me. The unpleasant smell I've had for months has disappeared. Although it caused slight constipation, this supplement is essential for me. Ingredients are safe, and it’s easy to consume.
Read More
9.5
Eases constipation
This daily probiotic supplement efficiently eases my occasional constipation and improves my digestive system’s health.
Read More
9.5
Normal digestion
These supplements are fantastic! I experienced no constipation and absorbed it well. The packaging is perfect, and unlike other pills, my gut felt normal. The high-quality ingredients are evident. I’m excited about the positive microbiome effects and will be purchasing it again.
Read More
9.5
Balances digestion
This supplement has been life-changing! Due to menopause, everything was unbalanced, but the ingredients in this product helped restore my gut microbiome, easing constipation and frequent UTIs.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Tan F, Kong CS. Inhibitory Effect of HFY11 on Compound Diphenoxylate-Induced Constipation in Mice. Biomolecules. 2025;15. doi:10.3390/biom15030358
- Guo K, Tang Y, Yang T, Yan Y. Massa Medicata Fermentata treated spleen deficiency constipation by mediating intestinal microbiota and serum peptide. Front Cell Infect Microbiol. 2025;15:1556915. doi:10.3389/fcimb.2025.1556915
- Li F, Wu D, Ma K, Wei T, Wu J, et al. Effect of dietary supplementation of Bacillus subtilis QST 713 on constipation, reproductive performance and offspring growth performance of sows. Anim Reprod Sci. 2025;274:107785. doi:10.1016/j.anireprosci.2025.107785
- Zhu S, Yu Q, Xue Y, Li J, Huang Y, et al. CCFM1163 alleviates cathartic colon by activating the BDNF-TrkB-PLC/IP pathway to reconstruct the intestinal nerve and barrier. Food Funct. 2025;16:2057. doi:10.1039/d4fo05835f
- Liu TH, Chen GL, Lin CH, Tsai TY, Cheng MC. TWK10 relieves loperamide-induced constipation in rats fed a high-fat diet modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota. Food Funct. 2025;16:181. doi:10.1039/d4fo02270j
- Zhao B, Wang Y, Wang S, Mu G, Wu X. Mechanism analysis of the differences in relieving constipation in a Balb/c constipation model mouse fed human milk probiotics or fermented milk. J Sci Food Agric. 2025;105:2594. doi:10.1002/jsfa.14032
- Zhang X, Jia Y, Li X, Wang X, Li L, et al. Effects of complex probiotics on intestinal function and its regulatory mechanism in patients with constipation. Benef Microbes. 2024;16:35. doi:10.1163/18762891-bja00039
- Tanihiro R, Yuki M, Sakano K, Sasai M, Sawada D, et al. Effects of Heat-Treated CP790-Fermented Milk on Gastrointestinal Health in Healthy Adults: A Randomized Double-Blind Placebo-Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16142191
- Yang WC, Zeng BS, Liang CS, Hsu CW, Su KP, et al. Efficacy and acceptability of different probiotic products plus laxatives for pediatric functional constipation: a network meta-analysis of randomized controlled trials. Eur J Pediatr. 2024;183:3531. doi:10.1007/s00431-024-05568-6
- Han Y, Zhou Y, Xu X, Chen S, Zhang S, et al. Improvement of Post-Surgery Constipation in Patients with Fractures by JYLR-127: A Single-Blind Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16101505
- Zhang C, Wang L, Liu X, Wang G, Guo X, et al. Different microbial ecological agents change the composition of intestinal microbiota and the levels of SCFAs in mice to alleviate loperamide-induced constipation. Benef Microbes. 2024;15:311. doi:10.1163/18762891-bja00011
- Tyrsin OY, Tyrsin DY, Nemenov DG, Ruzov AS, Odintsova VE, et al. Effect of Lactobacillus reuteri NCIMB 30351 drops on symptoms of infantile functional gastrointestinal disorders and gut microbiota in early infants: Results from a randomized, placebo-controlled clinical trial. Eur J Pediatr. 2024;183:2311. doi:10.1007/s00431-024-05473-y
- Yang C, Hu T, Xue X, Su X, Zhang X, et al. Multi-omics analysis of fecal microbiota transplantation's impact on functional constipation and comorbid depression and anxiety. BMC Microbiol. 2023;23:389. doi:10.1186/s12866-023-03123-1
- Cheng S, Li B, Ding Y, Hou B, Hung W, et al. The probiotic fermented milk of Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 alleviates constipation via improving gastrointestinal motility and gut microbiota. J Dairy Sci. 2024;107:1857. doi:10.3168/jds.2023-24154
- Peng Y, Ma Y, Luo Z, Jiang Y, Xu Z, et al. in digestive system diseases: focus on clinical trials and mechanisms. Front Cell Infect Microbiol. 2023;13:1254198. doi:10.3389/fcimb.2023.1254198
- Huh KY, Chung WK, Park J, Lee S, Kim MG, et al. Feasibility study for a fully decentralized clinical trial in participants with functional constipation symptoms. Clin Transl Sci. 2023;16:2177. doi:10.1111/cts.13617
- Xia T, Huang F, Yun F, Liu Y, Wang T, et al. LRJ-1 alleviates constipation through promoting gut -derived γ-aminobutyric acid production. Curr Res Food Sci. 2024;9:100924. doi:10.1016/j.crfs.2024.100924
- Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x
- Cheng S, Cui H, Zhang J, Wang Q, Duan Z. Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice. Sci Rep. 2024;14:1131. doi:10.1038/s41598-024-51497-7
- Jeong JJ, Ganesan R, Jin YJ, Park HJ, Min BH, et al. Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats. Front Microbiol. 2023;14:1174968. doi:10.3389/fmicb.2023.1174968
- Lai H, Li Y, He Y, Chen F, Mi B, et al. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes. 2023;15:2197837. doi:10.1080/19490976.2023.2197837
- Gu Y, Qin X, Zhou G, Wang C, Mu C, et al. GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota. Food Funct. 2022;13:12144. doi:10.1039/d2fo01900k
- Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
- Wang J, Yin L, Zheng W, Shi S, Hao W, et al. Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae. World J Microbiol Biotechnol. 2022;38:222. doi:10.1007/s11274-022-03409-y
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
- Rodríguez Arreola A, Solís Pacheco JR, Lacroix M, Balcazar López E, Navarro Hernández RE, et al. In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder. Nutr Hosp. 2021;38:152. doi:10.20960/nh.03335
- Reyna-Figueroa J, Bejarano-Juvera AA, García-Parra C, Barrón-Calvillo EE, Queipo-Garcia GE, et al. Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2021;43:e457. doi:10.1097/MPH.0000000000001956
- Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, Galindo-Delgado P, Contreras-Ochoa C, et al. Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients With Acute Leukemia. J Pediatr Hematol Oncol. 2019;41:468. doi:10.1097/MPH.0000000000001497
- Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. doi:10.3390/nu11040886
- Baştürk A, Artan R, Atalay A, Yılmaz A. Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study. Turk J Gastroenterol. 2017;28:388. doi:10.5152/tjg.2017.17097
- Wojtyniak K, Horvath A, Dziechciarz P, Szajewska H. Lactobacillus casei rhamnosus Lcr35 in the Management of Functional Constipation in Children: A Randomized Trial. J Pediatr. 2017;184:101. doi:10.1016/j.jpeds.2017.01.068
- Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015. doi:10.1002/14651858.CD004827.pub4
- Roos S, Dahlgren AL, Mao YK, Pallin A, Stanisz AM, et al. Therapeutic Value of Lactobacillus gasseri 345A in Chronic Constipation. Neurogastroenterol Motil. 2025. doi:10.1111/nmo.70012
- Cheng S, Li B, Ding Y, Hou B, Hung W, et al. The probiotic fermented milk of Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 alleviates constipation via improving gastrointestinal motility and gut microbiota. J Dairy Sci. 2024;107:1857. doi:10.3168/jds.2023-24154
