Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 50 Researches
8
USERS' SCORE
Good
Based on 72 Reviews
8.9
Supplement Facts
Serving Size: One (1) Capsule
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%**
Total Sugars
0 g
†
Incl. 0 g Added Sugars
0%**
Intelliflora™ Blend:
150 mg5 billion CFUs
Lactobacillus crispatus LBV 88
†
Lactobacillus rhamnosus LBV 96
†
Lactobacillus gasseri LBV 150N
†
Lactobacillus jensenii LBV 116
†
Top Medical Research Studies
9
We explored how lactic acid bacteria (LAB) can combat the harmful effects of Candida albicans, the fungus responsible for yeast infections. Through our study, we found that the supernatant from LAB like Lactobacillus crispatus and L. gasseri effectively inhibited the growth and harmful activity of C. albicans.
Specifically, L. gasseri showed exceptional ability in preventing the formation of biofilms and hyphae, crucial stages in fungal development. Additionally, the metabolites produced by these bacteria downregulated key genes associated with C. albicans, reinforcing their role in maintaining vaginal health.
Overall, while the findings are promising, further research is needed to confirm the clinical effectiveness of these metabolites in treating or preventing yeast infections.
Specifically, L. gasseri showed exceptional ability in preventing the formation of biofilms and hyphae, crucial stages in fungal development. Additionally, the metabolites produced by these bacteria downregulated key genes associated with C. albicans, reinforcing their role in maintaining vaginal health.
Overall, while the findings are promising, further research is needed to confirm the clinical effectiveness of these metabolites in treating or preventing yeast infections.
Read More
9
We examined the effect of lactic acid bacteria, particularly Lactobacillus gasseri, on the harmful yeast Candida albicans. Our study showed that the metabolites from L. gasseri effectively inhibit the yeast's ability to grow and form biofilms, crucial for its pathogenicity. The research also indicated that these beneficial bacteria can keep C. albicans in a less harmful state by downregulating important genes responsible for its virulence. Overall, L. gasseri appears to be a promising option in the fight against vaginal yeast infections.
Read More
8
We explored how Limosilactobacillus fermentum KBL674 impacts vaginal candidiasis, commonly caused by Candida albicans. In a mouse model, this probiotic strain significantly inhibited C. albicans growth and alleviated symptoms like tissue swelling and immune response. Interestingly, many of the administered L. fermentum KBL674 didn't remain in the gut; it altered gut bacteria diversity, linking these changes to reduced yeast infection severity. Overall, our findings suggest that L. fermentum KBL674 may offer a promising approach to help manage yeast infections.
Read More
Most Useful Reviews
10
Cleared up
Miracle cure. I typically don’t write reviews unless I feel strongly about a product. I’ve struggled with BV and yeast infections for about three years. After trying various treatments, I found myself in a frustrating cycle. Within two days of taking this product, everything cleared up. I now have no pH issues even after new partners. This product has truly cured me.
Read More
10
Cured infections
Wasn't expecting greatness. I never write reviews unless I really love a product, and this is one of those. It actually works. I struggled with BV and yeast infections every month after my period, which my doctor attributed to my birth control causing hormonal changes and an imbalance. My doctor frequently prescribed awful-tasting medication I had to take for 7 days, twice daily. I began researching probiotics and their ingredients for feminine health and stumbled upon this product. After a month of use, I can safely say, get it. I have not had a single infection since starting, and I just got off my period. No itching, no discharge, and no odour! I work out daily and noticed no smell at all. This product works wonders.
Read More
9.5
Effective treatment
Amazing. I am a 28-year-old female and for the last two years, I have struggled with my pH balance. I visited the gynaecologist multiple times a year, usually diagnosed with bacterial vaginosis, along with frequent yeast infections. I was at my wits' end! After trying various gels and pills with only temporary relief, a co-worker suggested a daily pill. After taking it for three months, I have had no issues since. I highly recommend this to anyone considering it!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 50 Researches
8
- All Researches
9.5
We investigated the potential of a specific strain of Lactobacillus gasseri, named VHProbi E09, to treat vaginitis and fight off common pathogens causing yeast infections. Through laboratory tests, we found that this strain effectively inhibited the growth of harmful bacteria and yeast by over 99%.
Additionally, it prevented these pathogens from adhering to vaginal cells, showing promise for future clinical applications. While these results are promising, further research is necessary to fully understand its effectiveness in clinical settings and its role in restoring normal vaginal flora.
Additionally, it prevented these pathogens from adhering to vaginal cells, showing promise for future clinical applications. While these results are promising, further research is necessary to fully understand its effectiveness in clinical settings and its role in restoring normal vaginal flora.
Read More
9.5
We investigated how Lactobacillus rhamnosus Lcr35, contained in the GYNOPHILUS product, can combat yeast infections like Candida. This study showed that the product’s formulation, enhanced by sodium thiosulfate, improves its ability to kill yeast cells.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Read More
9
We examined a new treatment, VAGINNE, derived from beneficial species to tackle vulvovaginal candidiasis (VVC). Using a mouse model, we observed that VAGINNE improved the balance of the vaginal microbiome while reducing harmful yeast growth.
Additionally, it lowered inflammatory markers in both vaginal tissue and blood, suggesting an anti-inflammatory effect. Our histological analysis showed better tissue integrity in treated mice compared to those without treatment.
These results indicate that VAGINNE can be a promising, side-effect-free alternative to conventional antifungals for managing VVC, especially in cases where drugs fail or cause issues.
Additionally, it lowered inflammatory markers in both vaginal tissue and blood, suggesting an anti-inflammatory effect. Our histological analysis showed better tissue integrity in treated mice compared to those without treatment.
These results indicate that VAGINNE can be a promising, side-effect-free alternative to conventional antifungals for managing VVC, especially in cases where drugs fail or cause issues.
Read More
9
We aimed to understand if adding probiotics to standard antifungal treatment improves outcomes for vulvovaginal candidiasis (VVC). In our study, 60 women diagnosed with VVC were divided into two groups.
One group received just antifungal medication, while the other received both antifungal and probiotic treatments.
Results indicated that those who took probiotics alongside their antifungal showed better improvement and had lower relapse rates. This suggests that probiotics can be a beneficial addition to standard yeast infection treatments.
One group received just antifungal medication, while the other received both antifungal and probiotic treatments.
Results indicated that those who took probiotics alongside their antifungal showed better improvement and had lower relapse rates. This suggests that probiotics can be a beneficial addition to standard yeast infection treatments.
Read More
9
We explored how lactic acid bacteria (LAB) can combat the harmful effects of Candida albicans, the fungus responsible for yeast infections. Through our study, we found that the supernatant from LAB like Lactobacillus crispatus and L. gasseri effectively inhibited the growth and harmful activity of C. albicans.
Specifically, L. gasseri showed exceptional ability in preventing the formation of biofilms and hyphae, crucial stages in fungal development. Additionally, the metabolites produced by these bacteria downregulated key genes associated with C. albicans, reinforcing their role in maintaining vaginal health.
Overall, while the findings are promising, further research is needed to confirm the clinical effectiveness of these metabolites in treating or preventing yeast infections.
Specifically, L. gasseri showed exceptional ability in preventing the formation of biofilms and hyphae, crucial stages in fungal development. Additionally, the metabolites produced by these bacteria downregulated key genes associated with C. albicans, reinforcing their role in maintaining vaginal health.
Overall, while the findings are promising, further research is needed to confirm the clinical effectiveness of these metabolites in treating or preventing yeast infections.
Read More
User Reviews
USERS' SCORE
Good
Based on 72 Reviews
8.9
- All Reviews
- Positive Reviews
- Negative Reviews
10
Cleared up
Miracle cure. I typically don’t write reviews unless I feel strongly about a product. I’ve struggled with BV and yeast infections for about three years. After trying various treatments, I found myself in a frustrating cycle. Within two days of taking this product, everything cleared up. I now have no pH issues even after new partners. This product has truly cured me.
Read More
10
Cured infections
Wasn't expecting greatness. I never write reviews unless I really love a product, and this is one of those. It actually works. I struggled with BV and yeast infections every month after my period, which my doctor attributed to my birth control causing hormonal changes and an imbalance. My doctor frequently prescribed awful-tasting medication I had to take for 7 days, twice daily. I began researching probiotics and their ingredients for feminine health and stumbled upon this product. After a month of use, I can safely say, get it. I have not had a single infection since starting, and I just got off my period. No itching, no discharge, and no odour! I work out daily and noticed no smell at all. This product works wonders.
Read More
9.5
Effective treatment
Amazing. I am a 28-year-old female and for the last two years, I have struggled with my pH balance. I visited the gynaecologist multiple times a year, usually diagnosed with bacterial vaginosis, along with frequent yeast infections. I was at my wits' end! After trying various gels and pills with only temporary relief, a co-worker suggested a daily pill. After taking it for three months, I have had no issues since. I highly recommend this to anyone considering it!
Read More
10
Yeast infection free
Best to balance ph. If you are suffering from recurring yeast infections, this product is what you need! I had several yeast infections last year, attributed to stress and perimenopause, which were dreadful. I discovered this product at my local grocery store and decided to try it. I have been yeast infection free for six months now. As a Prime member, it arrives at my home every month, ensuring I never miss a dose.
Read More
8.8
Reduced inflammation
My experience after giving birth led to an infection from prolonged use of sanitary napkins, necessitating antibiotics. Unfortunately, the infection returned. Fortunately, after using these tablets, my inflammation and itching alleviated. I cannot do without them.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Horng HC, Xu JW, Kuo YS, Chen YS, Chiu YH, et al. Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of Fermentation Broth in Treating Vulvovaginal Candidiasis. J Fungi (Basel). 2024;11. doi:10.3390/jof11010018
- Thekho AJ, Mendiratta V, Garg T, Kaur R, Yadav V. Role of Probiotic in Vulvovaginal Candidiasis: A Randomised Controlled Non-blinded Trial from India. Indian J Dermatol. 2024;69:422. doi:10.4103/ijd.ijd_193_24
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- Jang SJ, Jo EJ, Lee C, Cho BR, Shin YJ, et al. Limosilactobacillus fermentum KBL674 Alleviates Vaginal Candidiasis. Probiotics Antimicrob Proteins. 2024. doi:10.1007/s12602-024-10403-3
- Vazquez-Munoz R, Thompson A, Sobue T, Dongari-Bagtzoglou A. is a dominant in the murine oral mucosa and has chitinase activity that compromises fungal cell wall integrity. mBio. 2024;15:e0241624. doi:10.1128/mbio.02416-24
- Zhang J, Li K, Cao T, Duan Z. Characterization of a Lactobacillus gasseri strain as a probiotic for female vaginitis. Sci Rep. 2024;14:14426. doi:10.1038/s41598-024-65550-y
- Elsayes SA, El Attar MS, ElHadary A, Aboulela AG, Essawy MM, et al. Antimycotic prophylaxis with multispecies probiotics against oral candidiasis in new complete denture wearers: A randomized clinical trial. J Prosthet Dent. 2024. doi:10.1016/j.prosdent.2024.05.018
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- Faustino M, Pereira JO, Pereira AM, Oliveira AS, Ferreira CMH, et al. Vaginal prevention of Candida albicans: synergistic effect of lactobacilli and mannan oligosaccharides (MOS). Appl Microbiol Biotechnol. 2024;108:73. doi:10.1007/s00253-023-12909-2
- Das S, Konwar BK. Inhibiting pathogenicity of vaginal Candida albicans by lactic acid bacteria and MS analysis of their extracellular compounds. APMIS. 2024;132:161. doi:10.1111/apm.13365
- Deshkar S, Yeole P, Mahore J, Shinde A, Giram P. Polyelectrolyte-Complex-Based Hydrogel Inserts for Vaginal Delivery of Posaconazole and Probiotics. Gels. 2023;9. doi:10.3390/gels9110851
- ElFeky DS, Awad AR, Shamseldeen AM, Mowafy HL, Hosny SA. Comparing the therapeutic potentials of vs. against vulvovaginal candidiasis in female rats: an study. Front Microbiol. 2023;14:1222503. doi:10.3389/fmicb.2023.1222503
- Faustino M, Pereira JO, Pereira AM, Oliveira AS, Ferreira CMH, et al. Vaginal prevention of Candida albicans: synergistic effect of lactobacilli and mannan oligosaccharides (MOS). Appl Microbiol Biotechnol. 2024;108:73. doi:10.1007/s00253-023-12909-2
- Das S, Konwar BK. Inhibiting pathogenicity of vaginal Candida albicans by lactic acid bacteria and MS analysis of their extracellular compounds. APMIS. 2024;132:161. doi:10.1111/apm.13365
- Giordani B, Naldi M, Croatti V, Parolin C, Erdoğan Ü, et al. Exopolysaccharides from vaginal lactobacilli modulate microbial biofilms. Microb Cell Fact. 2023;22:45. doi:10.1186/s12934-023-02053-x
- Kumherová M, Veselá K, Kosová M, Mašata J, Horáčková Š, et al. Novel Potential Probiotic Lactobacilli for Prevention and Treatment of Vulvovaginal Infections. Probiotics Antimicrob Proteins. 2021;13:163. doi:10.1007/s12602-020-09675-2
- De Gregorio PR, Parolin C, Abruzzo A, Luppi B, Protti M, et al. Biosurfactant from vaginal Lactobacillus crispatus BC1 as a promising agent to interfere with Candida adhesion. Microb Cell Fact. 2020;19:133. doi:10.1186/s12934-020-01390-5
- Jang SJ, Lee K, Kwon B, You HJ, Ko G. Vaginal lactobacilli inhibit growth and hyphae formation of Candida albicans. Sci Rep. 2019;9:8121. doi:10.1038/s41598-019-44579-4
- Er S, İstanbullu Tosun A, Arık G, Kıvanç M. Anticandidal activities of lactic acid bacteria isolated from the vagina. Turk J Med Sci. 2019;49:375. doi:10.3906/sag-1709-143
- Matsuda Y, Cho O, Sugita T, Ogishima D, Takeda S. Culture Supernatants of Lactobacillus gasseri and L. crispatus Inhibit Candida albicans Biofilm Formation and Adhesion to HeLa Cells. Mycopathologia. 2018;183:691. doi:10.1007/s11046-018-0259-4
- Zhang X, Li T, Niu XX, Wang SX, Liu ZH. [Scanning electron microscopic observation of interactions of vaginal epithelial cells with Candida albicans and Lactobacillus crispatus]. Zhonghua Fu Chan Ke Za Zhi. 2017;52:618. doi:10.3760/cma.j.issn.0529-567X.2017.09.008
- Niu XX, Li T, Zhang X, Wang SX, Liu ZH. Modulates Vaginal Epithelial Cell Innate Response to . Chin Med J (Engl). 2017;130:273. doi:10.4103/0366-6999.198927
- Parolin C, Marangoni A, Laghi L, Foschi C, Ñahui Palomino RA, et al. Isolation of Vaginal Lactobacilli and Characterization of Anti-Candida Activity. PLoS One. 2015;10:e0131220. doi:10.1371/journal.pone.0131220
- Rizzo A, Losacco A, Carratelli CR. Lactobacillus crispatus modulates epithelial cell defense against Candida albicans through Toll-like receptors 2 and 4, interleukin 8 and human β-defensins 2 and 3. Immunol Lett. 2013;156:102. doi:10.1016/j.imlet.2013.08.013
- Chantanawilas P, Pahumunto N, Thananimit S, Teanpaisan R. Anticandidal Activity of Various Probiotic Lactobacillus Strains and Their Efficacy Enhanced by Prebiotic Supplementation. Curr Microbiol. 2024;81:271. doi:10.1007/s00284-024-03800-y
- Pimentel MMNSC, de Carvalho Alves J, Pinheiro LHS, Roselino MN. Potential Action of Probiotics Against Fungi of the Genus : A Bibliographic Review. Recent Pat Biotechnol. 2023;17:198. doi:10.2174/1872208317666221027093644
- Spaggiari L, Sala A, Ardizzoni A, De Seta F, Singh DK, et al. Lactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture System . Microbiol Spectr. 2022;10:e0269621. doi:10.1128/spectrum.02696-21
- Dausset C, Bornes S, Miquel S, Kondjoyan N, Angenieux M, et al. Identification of sulfur components enhancing the anti-Candida effect of Lactobacillus rhamnosus Lcr35. Sci Rep. 2020;10:17074. doi:10.1038/s41598-020-74027-7
- Kumherová M, Veselá K, Kosová M, Mašata J, Horáčková Š, et al. Novel Potential Probiotic Lactobacilli for Prevention and Treatment of Vulvovaginal Infections. Probiotics Antimicrob Proteins. 2021;13:163. doi:10.1007/s12602-020-09675-2
- Poupet C, Saraoui T, Veisseire P, Bonnet M, Dausset C, et al. Lactobacillus rhamnosus Lcr35 as an effective treatment for preventing Candida albicans infection in the invertebrate model Caenorhabditis elegans: First mechanistic insights. PLoS One. 2019;14:e0216184. doi:10.1371/journal.pone.0216184
- Lee X, Vergara C, Lozano CP. Severity of Candida-associated denture stomatitis is improved in institutionalized elders who consume Lactobacillus rhamnosus SP1. Aust Dent J. 2019;64:229. doi:10.1111/adj.12692
- De Gregorio PR, Silva JA, Marchesi A, Nader-Macías MEF. Anti-Candida activity of beneficial vaginal lactobacilli in in vitro assays and in a murine experimental model. FEMS Yeast Res. 2019;19. doi:10.1093/femsyr/foz008
- Leão MVP, Tavares TAA, Gonçalves E Silva CR, Dos Santos SSF, Junqueira JC, et al. Lactobacillus rhamnosus intake can prevent the development of Candidiasis. Clin Oral Investig. 2018;22:2511. doi:10.1007/s00784-018-2347-8
- Rossoni RD, Dos Santos Velloso M, Figueiredo LMA, Martins CP, Jorge AOC, et al. Clinical strains of Lactobacillus reduce the filamentation of Candida albicans and protect Galleria mellonella against experimental candidiasis. Folia Microbiol (Praha). 2018;63:307. doi:10.1007/s12223-017-0569-9
- Tan Y, Leonhard M, Moser D, Ma S, Schneider-Stickler B. Inhibitory effect of probiotic lactobacilli supernatants on single and mixed non-albicans Candida species biofilm. Arch Oral Biol. 2018;85:40. doi:10.1016/j.archoralbio.2017.10.002
- Mailänder-Sánchez D, Braunsdorf C, Grumaz C, Müller C, Lorenz S, et al. Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLoS One. 2017;12:e0184438. doi:10.1371/journal.pone.0184438
- de Oliveira FE, Rossoni RD, de Barros PP, Begnini BE, Junqueira JC, et al. Immunomodulatory effects and anti-Candida activity of lactobacilli in macrophages and in invertebrate model of Galleria mellonella. Microb Pathog. 2017;110:603. doi:10.1016/j.micpath.2017.08.006
- Das S, Konwar BK. Inhibiting pathogenicity of vaginal Candida albicans by lactic acid bacteria and MS analysis of their extracellular compounds. APMIS. 2024;132:161. doi:10.1111/apm.13365
- Giordani B, Naldi M, Croatti V, Parolin C, Erdoğan Ü, et al. Exopolysaccharides from vaginal lactobacilli modulate microbial biofilms. Microb Cell Fact. 2023;22:45. doi:10.1186/s12934-023-02053-x
- Pimentel MMNSC, de Carvalho Alves J, Pinheiro LHS, Roselino MN. Potential Action of Probiotics Against Fungi of the Genus : A Bibliographic Review. Recent Pat Biotechnol. 2023;17:198. doi:10.2174/1872208317666221027093644
- Rodríguez-Arias RJ, Guachi-Álvarez BO, Montalvo-Vivero DE, Machado A. Lactobacilli displacement and Candida albicans inhibition on initial adhesion assays: a probiotic analysis. BMC Res Notes. 2022;15:239. doi:10.1186/s13104-022-06114-z
- Matsuda Y, Cho O, Sugita T, Ogishima D, Takeda S. Culture Supernatants of Lactobacillus gasseri and L. crispatus Inhibit Candida albicans Biofilm Formation and Adhesion to HeLa Cells. Mycopathologia. 2018;183:691. doi:10.1007/s11046-018-0259-4
- Calonghi N, Parolin C, Sartor G, Verardi L, Giordani B, et al. Interaction of vaginal Lactobacillus strains with HeLa cells plasma membrane. Benef Microbes. 2017;8:625. doi:10.3920/BM2016.0212
- Terayama Y, Matsuura T, Uchida M, Narama I, Ozaki K. Probiotic (yogurt) containing Lactobacillus gasseri OLL2716 is effective for preventing Candida albicans-induced mucosal inflammation and proliferation in the forestomach of diabetic rats. Histol Histopathol. 2016;31:689. doi:10.14670/HH-11-710
- Parolin C, Marangoni A, Laghi L, Foschi C, Ñahui Palomino RA, et al. Isolation of Vaginal Lactobacilli and Characterization of Anti-Candida Activity. PLoS One. 2015;10:e0131220. doi:10.1371/journal.pone.0131220
- Mastromarino P, Brigidi P, Macchia S, Maggi L, Pirovano F, et al. Characterization and selection of vaginal Lactobacillus strains for the preparation of vaginal tablets. J Appl Microbiol. 2002;93:884.
