5/3/2025
Last update
5/3/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.9
USERS' SCORE
Good
Based on 1 Review
8.4
Supplement Facts
Serving Size: Two (2) softgels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%**
Total Carbohydrate
<1 g
<1%**
Vitamin C (as ascorbic acid)
120 mg
133%
Pacran® Whole Fruit Cranberry (Vaccinium macrocarpon)
500 mg
†
Top Medical Research Studies
9
We explored the impact of whole cranberry powder (WCP) on preventing colon cancer in a study that involved mice with colitis-induced tumorigenesis. By incorporating WCP into the diet of these mice, we found that it significantly reduced the incidence and size of tumors compared to those that did not receive the cranberry treatment.
The findings highlighted a notable decrease in inflammatory markers, suggesting that WCP may play a vital role in relaxing the body's inflammatory response. Specifically, levels of pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α were markedly lower in the WCP-treated mice, indicating that the powder may help to counteract the processes that lead to tumor growth.
Additionally, WCP demonstrated its ability to influence various cellular pathways that are critical in cancer development, including those related to inflammation, cell growth, and even potential metastasis. This evidence supports the hypothesis that whole cranberry can be a beneficial addition to our diets when aiming to promote colon health and reduce the risk of cancer.
The findings highlighted a notable decrease in inflammatory markers, suggesting that WCP may play a vital role in relaxing the body's inflammatory response. Specifically, levels of pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α were markedly lower in the WCP-treated mice, indicating that the powder may help to counteract the processes that lead to tumor growth.
Additionally, WCP demonstrated its ability to influence various cellular pathways that are critical in cancer development, including those related to inflammation, cell growth, and even potential metastasis. This evidence supports the hypothesis that whole cranberry can be a beneficial addition to our diets when aiming to promote colon health and reduce the risk of cancer.
Read More
8
We examined how cranberries, specifically their polyphenols, could help in the fight against cancer, focusing on their effects on colon cancer. Our research highlighted the distinction between extractable polyphenols (EPs) and non-extractable polyphenols (NEPs) found in whole cranberries, aiming to explore their potential health benefits.
Through our analysis, we found that NEPs, which are typically overlooked in favor of EPs, exhibited a stronger ability to combat inflammation and colon cancer. Notably, NEPs were more effective than EPs in inhibiting the growth of human colon cancer cells in test tubes. This was shown by a significant reduction in the cancer cells' viability and their ability to form colonies.
Additionally, NEPs prompted cancer cells to undergo cell cycle arrest and increased their rate of apoptosis (cell death), suggesting a powerful role in cancer prevention. Both types of polyphenols in cranberries demonstrated anti-inflammatory properties, reducing harmful nitric oxide production in immune cells. Overall, our findings suggest that cranberries could offer valuable health benefits in addressing inflammation and fighting colon cancer.
Through our analysis, we found that NEPs, which are typically overlooked in favor of EPs, exhibited a stronger ability to combat inflammation and colon cancer. Notably, NEPs were more effective than EPs in inhibiting the growth of human colon cancer cells in test tubes. This was shown by a significant reduction in the cancer cells' viability and their ability to form colonies.
Additionally, NEPs prompted cancer cells to undergo cell cycle arrest and increased their rate of apoptosis (cell death), suggesting a powerful role in cancer prevention. Both types of polyphenols in cranberries demonstrated anti-inflammatory properties, reducing harmful nitric oxide production in immune cells. Overall, our findings suggest that cranberries could offer valuable health benefits in addressing inflammation and fighting colon cancer.
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9
We delved into how vitamin C might influence cancer treatment, focusing on its effects on the immune system. Our findings revealed that vitamin C directly modifies certain proteins, leading to a new type of protein change called vitcylation. This process specifically affects a protein known as STAT1.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
Read More
Most Useful Reviews
7.5
Prevents infections
9 people found this helpful
This product is excellent as it helps balance my bladder pH and prevents me from having UTIs. It is also a great antioxidant beneficial for both men and women while helping to prevent cancer.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.9
- All Researches
9
We delved into how vitamin C might influence cancer treatment, focusing on its effects on the immune system. Our findings revealed that vitamin C directly modifies certain proteins, leading to a new type of protein change called vitcylation. This process specifically affects a protein known as STAT1.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
By modifying STAT1, vitamin C enhances its ability to signal for immune responses. We found that this modification occurs in both controlled environments and living cells, depending on factors like dosage and acidity. As a result of vitcylation, the action of STAT1 is improved, which activates important immune responses in tumor cells and boosts the expression of molecules that help the immune system recognize and attack cancer cells.
Interestingly, this research sheds light on the potential of vitamin C as a treatment that not only affects cancer directly but also empowers the body’s own defenses. These insights pave the way for new approaches to cancer therapy that leverage the immune system in conjunction with vitamin C.
Read More
9
In our investigation, we assessed how extracts from Vaccinium macrocarpon, commonly known as cranberry, influence cancer cells. We found that these fruit extracts showed promising anticancer properties, particularly their ability to inhibit the growth of specific human cancer cell lines associated with prostate and renal cancers.
We conducted a series of in vitro tests, including evaluating their cytotoxic effects on the PPC-1 prostate carcinoma and CaKi-1 renal carcinoma cell lines. Notably, the ethanolic extracts we tested displayed significant selectivity, using less of the extracts to effectively target cancer cells while sparing normal fibroblast cells. This specificity is crucial as it suggests that cranberry extracts could potentially minimize side effects associated with traditional cancer treatments.
Additionally, we observed that cranberry extracts not only reduced the size of cancer spheroids but also hampered the migration of cancer cells, which is an essential factor in cancer metastasis. These findings provide exciting insights into the potential use of cranberry fruit extracts as natural agents in cancer therapy, paving the way for further research in this area.
We conducted a series of in vitro tests, including evaluating their cytotoxic effects on the PPC-1 prostate carcinoma and CaKi-1 renal carcinoma cell lines. Notably, the ethanolic extracts we tested displayed significant selectivity, using less of the extracts to effectively target cancer cells while sparing normal fibroblast cells. This specificity is crucial as it suggests that cranberry extracts could potentially minimize side effects associated with traditional cancer treatments.
Additionally, we observed that cranberry extracts not only reduced the size of cancer spheroids but also hampered the migration of cancer cells, which is an essential factor in cancer metastasis. These findings provide exciting insights into the potential use of cranberry fruit extracts as natural agents in cancer therapy, paving the way for further research in this area.
Read More
9
We evaluated how extracts from the cranberry plant, known scientifically as Vaccinium macrocarpon, could affect cancer, particularly acute myeloid leukemia (AML). Our focus was on A-type proanthocyanidins (A-PACs), compounds found in cranberries that have demonstrated anticancer properties.
Testing these A-PACs involved leukemia cell lines, primary AML samples, and normal cord blood cells. What we found was exciting: these compounds showed strong and specific activity against leukemia in the lab. Importantly, they seemed to target the malignant progenitor and stem cell populations without harming normal blood cells.
The benefits of the A-PACs were not just limited to our lab settings. When we conducted further tests using models derived from patients, the antileukemia effects continued to hold true. Interestingly, the mechanism behind the cell death triggered by A-PACs appears to be linked to the activation of a pathway known as NF-κB.
Ultimately, our findings suggest that A-PACs could have a significant role in enhancing future treatments for AML, especially by targeting the often-resistant leukemia stem cells. This research opens exciting doors for new therapeutic approaches that may be less harmful to healthy cells while combating this challenging disease.
Testing these A-PACs involved leukemia cell lines, primary AML samples, and normal cord blood cells. What we found was exciting: these compounds showed strong and specific activity against leukemia in the lab. Importantly, they seemed to target the malignant progenitor and stem cell populations without harming normal blood cells.
The benefits of the A-PACs were not just limited to our lab settings. When we conducted further tests using models derived from patients, the antileukemia effects continued to hold true. Interestingly, the mechanism behind the cell death triggered by A-PACs appears to be linked to the activation of a pathway known as NF-κB.
Ultimately, our findings suggest that A-PACs could have a significant role in enhancing future treatments for AML, especially by targeting the often-resistant leukemia stem cells. This research opens exciting doors for new therapeutic approaches that may be less harmful to healthy cells while combating this challenging disease.
Read More
9
We explored the impact of whole cranberry powder (WCP) on preventing colon cancer in a study that involved mice with colitis-induced tumorigenesis. By incorporating WCP into the diet of these mice, we found that it significantly reduced the incidence and size of tumors compared to those that did not receive the cranberry treatment.
The findings highlighted a notable decrease in inflammatory markers, suggesting that WCP may play a vital role in relaxing the body's inflammatory response. Specifically, levels of pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α were markedly lower in the WCP-treated mice, indicating that the powder may help to counteract the processes that lead to tumor growth.
Additionally, WCP demonstrated its ability to influence various cellular pathways that are critical in cancer development, including those related to inflammation, cell growth, and even potential metastasis. This evidence supports the hypothesis that whole cranberry can be a beneficial addition to our diets when aiming to promote colon health and reduce the risk of cancer.
The findings highlighted a notable decrease in inflammatory markers, suggesting that WCP may play a vital role in relaxing the body's inflammatory response. Specifically, levels of pro-inflammatory cytokines like IL-1β, IL-6, and TNF-α were markedly lower in the WCP-treated mice, indicating that the powder may help to counteract the processes that lead to tumor growth.
Additionally, WCP demonstrated its ability to influence various cellular pathways that are critical in cancer development, including those related to inflammation, cell growth, and even potential metastasis. This evidence supports the hypothesis that whole cranberry can be a beneficial addition to our diets when aiming to promote colon health and reduce the risk of cancer.
Read More
8
We investigated how cranberry extract, specifically from the Vaccinium macrocarpon plant, influences lung adenocarcinoma (LUAD) cells. Our study aimed to build on existing research, particularly since previous investigations mostly focused on large-cell lung cancer.
For our experiments, we treated A549 LUAD cancer cells with commercial cranberry extract and measured various outcomes. We looked at the growth of these cancer cells using specific assays and also evaluated whether the extract could induce apoptosis, or programmed cell death, by assessing caspase-3 activity.
The findings were promising—we observed a noticeable reduction in the proliferation of A549 cells when treated with cranberry extract. This indicated that cranberry might help inhibit cancer cell growth. Moreover, we noticed increased activity of caspase-3, suggesting that the extract encourages cancer cells to undergo apoptosis. We also found that treatment with the extract decreased the levels of certain molecules associated with cell proliferation while increasing pro-apoptotic markers.
Overall, our research supports the idea that cranberry extract has the potential to inhibit the growth of LUAD cells by affecting both cell proliferation and apoptosis pathways. This provides an exciting avenue for future treatment strategies targeting lung cancer.
For our experiments, we treated A549 LUAD cancer cells with commercial cranberry extract and measured various outcomes. We looked at the growth of these cancer cells using specific assays and also evaluated whether the extract could induce apoptosis, or programmed cell death, by assessing caspase-3 activity.
The findings were promising—we observed a noticeable reduction in the proliferation of A549 cells when treated with cranberry extract. This indicated that cranberry might help inhibit cancer cell growth. Moreover, we noticed increased activity of caspase-3, suggesting that the extract encourages cancer cells to undergo apoptosis. We also found that treatment with the extract decreased the levels of certain molecules associated with cell proliferation while increasing pro-apoptotic markers.
Overall, our research supports the idea that cranberry extract has the potential to inhibit the growth of LUAD cells by affecting both cell proliferation and apoptosis pathways. This provides an exciting avenue for future treatment strategies targeting lung cancer.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Prevents infections
9 people found this helpful
This product is excellent as it helps balance my bladder pH and prevents me from having UTIs. It is also a great antioxidant beneficial for both men and women while helping to prevent cancer.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- He X, Wang Q, Cheng X, Wang W, Li Y, et al. Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response. Cell. 2025. 10.1016/j.cell.2025.01.043
- Šedbarė R, Janulis V, Pavilonis A, Petrikaite V. Comparative In Vitro Study: Assessing Phytochemical, Antioxidant, Antimicrobial, and Anticancer Properties of Aiton and L. Fruit Extracts. Pharmaceutics. 2024;16. 10.3390/pharmaceutics16060735
- Esquivel-Chirino C, Bolaños-Carrillo MA, Carmona-Ruiz D, Lopéz-Macay A, Hernández-Sánchez F, et al. The Protective Role of Cranberries and Blueberries in Oral Cancer. Plants (Basel). 2023;12. 10.3390/plants12122330
- Zhao L, Kaser E, Lequio M, D'Mello K, Xiao H, et al. Say 'No' to Cancer and 'Yes' to Cranberry: The Role of Cranberry Extract in Inhibition of Growth of Lung Adenocarcinoma Cells. Anticancer Res. 2023;43:2933. 10.21873/anticanres.16464
- Tamkutė L, Jančiukė G, Pukalskienė M, Sarapinienė I, Arvydas Skeberdis V, et al. Cranberry and black chokeberry extracts isolated with pressurized ethanol from defatted by supercritical CO pomace inhibit colorectal carcinoma cells and increase global antioxidant response of meat products during in vitro digestion. Food Res Int. 2022;161:111803. 10.1016/j.foodres.2022.111803
- Weh KM, Zhang Y, Howard CL, Howell AB, Clarke JL, et al. Cranberry Polyphenols in Esophageal Cancer Inhibition: New Insights. Nutrients. 2022;14. 10.3390/nu14050969
- Bai Q, Hunzeker ZE, Zhu Z, Lequio M, Willson CM, et al. Cranberry Extract Is a Potent Radiosensitizer for Glioblastoma. Anticancer Res. 2021;41:3337. 10.21873/anticanres.15121
- Ankola AV, Kumar V, Thakur S, Singhal R, Smitha T, et al. Anticancer and antiproliferative efficacy of a standardized extract of on the highly differentiating oral cancer KB cell line athwart the cytotoxicity evaluation of the same on the normal fibroblast L929 cell line. J Oral Maxillofac Pathol. 2020;24:258. 10.4103/jomfp.JOMFP_129_20
- Wu X, Xue L, Tata A, Song M, Neto CC, et al. Bioactive Components of Polyphenol-Rich and Non-Polyphenol-Rich Cranberry Fruit Extracts and Their Chemopreventive Effects on Colitis-Associated Colon Cancer. J Agric Food Chem. 2020;68:6845. 10.1021/acs.jafc.0c02604
- Desrouillères K, Millette M, Bagheri L, Maherani B, Jamshidian M, et al. The synergistic effect of cell wall extracted from probiotic biomass containing Lactobacillus acidophilus CL1285, L. casei LBC80R, and L. rhamnosus CLR2 on the anticancer activity of cranberry juice-HPLC fractions. J Food Biochem. 2020;44:e13195. 10.1111/jfbc.13195
- Mansouri RA, Percival SS. Cranberry extract initiates intrinsic apoptosis in HL-60 cells by increasing BAD activity through inhibition of AKT phosphorylation. BMC Complement Med Ther. 2020;20:71. 10.1186/s12906-020-2870-4
- Han Y, Huang M, Li L, Cai X, Gao Z, et al. Non-extractable polyphenols from cranberries: potential anti-inflammation and anti-colon-cancer agents. Food Funct. 2019;10:7714. 10.1039/c9fo01536a
- Bystrom LM, Bezerra DP, Hsu HT, Zong H, Lara-Martínez LA, et al. Cranberry A-type proanthocyanidins selectively target acute myeloid leukemia cells. Blood Adv. 2019;3:3261. 10.1182/bloodadvances.2018026633
- Mantzorou M, Zarros A, Vasios G, Theocharis S, Pavlidou E, et al. Cranberry: A Promising Natural Source of Potential Nutraceuticals with Anticancer Activity. Anticancer Agents Med Chem. 2019;19:1672. 10.2174/1871520619666190704163301
- Wu X, Song M, Cai X, Neto C, Tata A, et al. Chemopreventive Effects of Whole Cranberry (Vaccinium macrocarpon) on Colitis-Associated Colon Tumorigenesis. Mol Nutr Food Res. 2018;62:e1800942. 10.1002/mnfr.201800942
- Bonetta A, Roviello G, Generali D, Zanotti L, Cappelletti MR, et al. Enteric-coated and highly standardized cranberry extract reduces antibiotic and nonsteroidal anti-inflammatory drug use for urinary tract infections during radiotherapy for prostate carcinoma. Res Rep Urol. 2017;9:65. 10.2147/RRU.S133538
- Prasain JK, Rajbhandari R, Keeton AB, Piazza GA, Barnes S. Metabolism and growth inhibitory activity of cranberry derived flavonoids in bladder cancer cells. Food Funct. 2016;7:4012.
