Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 33 Researches
7.8
USERS' SCORE
Good
Based on 14 Reviews
8.7
Supplement Facts
Serving Size: One (1) Capsule
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%+
Total Sugars
0 g
**
Incl. 0 g Added Sugars
0%+
A Proprietary Probiotic Blend
154 mg (15 billion CFUs)
Lactobacillus crispatus LBV 88
**
Lactobacillus rhamnosus LBV 96
**
Lactobacillus rhamnosus GG
**
Lactobacillus gasseri LBV 150N
**
Lactobacillus jensenii LBV 116
**
A Proprietary Prebiotic Blend
15 mg
Myoviridae LH01
**
Siphoviridae LL5
**
Myoviridae T4D
**
Myoviridae LL12
**
Top Medical Research Studies
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
8
Lactobacillus shows promise for constipation
We investigated the effects of a new microbial strain, LP-HFY11, on constipation caused by a common medication in mice. The results showed that LP-HFY11 helped maintain fecal weight and improved gut movement. Those given a high dose expelled stool faster than others treated with lactulose, although still slower than in normal mice.
Interestingly, LP-HFY11 also promoted positive changes in intestinal health and increased certain beneficial substances in the bloodstream, suggesting it could serve as an effective probiotic for constipation management. There appears to be promising potential for LP-HFY11's use in both the food and pharmaceutical industries.
Interestingly, LP-HFY11 also promoted positive changes in intestinal health and increased certain beneficial substances in the bloodstream, suggesting it could serve as an effective probiotic for constipation management. There appears to be promising potential for LP-HFY11's use in both the food and pharmaceutical industries.
Read More
7
Lactobacillus gasseri alleviates constipation symptoms
We conducted a comprehensive study to determine how Lactobacillus gasseri impacts chronic constipation. The clinical trial involved 40 women who were given either Lactobacillus gasseri or a placebo over a 28-day period.
Our findings revealed that this probiotic strain significantly reduced abdominal pain and suggested an increase in complete spontaneous bowel movements. While the results are promising, we did not observe a major breakthrough in bowel function improvement.
Overall, Lactobacillus gasseri may help relieve some symptoms associated with functional constipation.
Our findings revealed that this probiotic strain significantly reduced abdominal pain and suggested an increase in complete spontaneous bowel movements. While the results are promising, we did not observe a major breakthrough in bowel function improvement.
Overall, Lactobacillus gasseri may help relieve some symptoms associated with functional constipation.
Read More
Most Useful Reviews
9
Daily regularity achieved
241 people found this helpful
I advocate for probiotics when dealing with constipation. After starting these daily, I noticed improvements in regularity within just a few days, despite previous challenges even with fibre-rich foods. My experience with other brands was disappointing, but these have proven effective.
Read More
9
Improved digestion
1 people found this helpful
I have noticed a significant improvement in my digestive system and intestinal transit; my constipation is resolving, and the inflammation is diminishing.
Read More
10
Improves digestion
I recommend it to everyone. It's a quality product for health. After using this medication, my digestion has improved significantly, and there is no constipation anymore.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 33 Researches
7.8
- All Researches
9
We explored the potential of the probiotic CCFM1163 to alleviate slow-transit constipation caused by prolonged laxative use, known as cathartic colon. Using a mouse model, we observed how this probiotic affects the gut's nerve and barrier functions.
The findings revealed that CCFM1163 enhances the expression of brain-derived neurotrophic factor (BDNF), which activates a key signaling pathway, helping to restore gut health. As a result, it significantly improved intestinal function, offering hope for those suffering from this condition.
The findings revealed that CCFM1163 enhances the expression of brain-derived neurotrophic factor (BDNF), which activates a key signaling pathway, helping to restore gut health. As a result, it significantly improved intestinal function, offering hope for those suffering from this condition.
Read More
9
Probiotics effectively relieve constipation
We explored how specific microbial agents can change the gut bacteria and help relieve constipation in mice. The study focused on two treatments, including Lactobacillus, and found they increased beneficial gut bacteria and improved peristalsis, which is the movement that helps waste pass through the intestines.
Notably, one agent, PE0401, showed a better ability to alleviate constipation symptoms by enhancing gut health and reducing inflammation. The results suggest that probiotics can play a positive role in managing constipation.
Notably, one agent, PE0401, showed a better ability to alleviate constipation symptoms by enhancing gut health and reducing inflammation. The results suggest that probiotics can play a positive role in managing constipation.
Read More
9
Lactobacillus reduces constipation symptoms
We explored the effects of a fermented milk product containing two specific probiotic strains, Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1, on relieving constipation in mice.
Over 14 days, we found that this probiotic mix enhanced gastrointestinal function by boosting the secretion of important gut hormones and increasing beneficial bacteria while reducing harmful ones.
Our findings suggest this fermented milk could be a useful approach to managing constipation and improving gut health.
Over 14 days, we found that this probiotic mix enhanced gastrointestinal function by boosting the secretion of important gut hormones and increasing beneficial bacteria while reducing harmful ones.
Our findings suggest this fermented milk could be a useful approach to managing constipation and improving gut health.
Read More
9
We investigated the effects of Lactobacillus rhamnosus (LRJ-1) on constipation in mice. The study revealed that oral treatment with LRJ-1 led to significant improvements in constipation by increasing levels of a gut compound called γ-aminobutyric acid (GABA).
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
Read More
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Daily regularity achieved
241 people found this helpful
I advocate for probiotics when dealing with constipation. After starting these daily, I noticed improvements in regularity within just a few days, despite previous challenges even with fibre-rich foods. My experience with other brands was disappointing, but these have proven effective.
Read More
9
Improved digestion
1 people found this helpful
I have noticed a significant improvement in my digestive system and intestinal transit; my constipation is resolving, and the inflammation is diminishing.
Read More
10
Improves digestion
I recommend it to everyone. It's a quality product for health. After using this medication, my digestion has improved significantly, and there is no constipation anymore.
Read More
9
Effective for constipation
This is a great probiotic for daily use. I'm pleased with my purchase as it's effective against constipation and supports female microflora.
Read More
9
Helps intestinal diseases
I consume it each evening before bed. The packaging is good, it prevents constipation, and effectively aids with intestinal issues.
Read More
Frequently Asked Questions
9
Improved digestion
1 people found this helpful
I have noticed a significant improvement in my digestive system and intestinal transit; my constipation is resolving, and the inflammation is diminishing.
10
Improves digestion
I recommend it to everyone. It's a quality product for health. After using this medication, my digestion has improved significantly, and there is no constipation anymore.
9
Better gut health
This is a good probiotic for women, with excellent quality. Trying it for the first time has yielded great results for me; I now have no more constipation and improved gut health.
7.5
High absorption
The small package is adequate for a month. The quality is excellent. I felt a lot of relief from inflammation and burning after use. It absorbs well, does not cause constipation, and is easy to digest.
9
Restores microbiome
This supplement restores the microbiome and boasts good absorption benefits for digestion, with quality natural ingredients that eliminate constipation.
9
Helps intestinal diseases
I consume it each evening before bed. The packaging is good, it prevents constipation, and effectively aids with intestinal issues.
9
We examined the effects of Lacticaseibacillus rhamnosus IDCC 3201 on patients suffering from irritable bowel syndrome with constipation (IBS-C). In a robust study involving 30 participants, we used a randomized, double-blind, placebo-controlled design.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
8
We conducted a study to see if heat-treated CP790-fermented milk can improve symptoms of constipation and gut health. In a well-structured trial involving 120 healthy adults, we provided participants with either the fermented milk or a placebo for four weeks.
Results showed that those who consumed the fermented milk experienced better stool consistency and less straining during defecation. Not only did this treatment help with constipation, but it also positively impacted mood.
All in all, our findings suggest that CP790-fermented milk is a promising option for improving gut health and alleviating constipation symptoms.
Results showed that those who consumed the fermented milk experienced better stool consistency and less straining during defecation. Not only did this treatment help with constipation, but it also positively impacted mood.
All in all, our findings suggest that CP790-fermented milk is a promising option for improving gut health and alleviating constipation symptoms.
7
Lactobacillus gasseri alleviates constipation symptoms
We conducted a comprehensive study to determine how Lactobacillus gasseri impacts chronic constipation. The clinical trial involved 40 women who were given either Lactobacillus gasseri or a placebo over a 28-day period.
Our findings revealed that this probiotic strain significantly reduced abdominal pain and suggested an increase in complete spontaneous bowel movements. While the results are promising, we did not observe a major breakthrough in bowel function improvement.
Overall, Lactobacillus gasseri may help relieve some symptoms associated with functional constipation.
Our findings revealed that this probiotic strain significantly reduced abdominal pain and suggested an increase in complete spontaneous bowel movements. While the results are promising, we did not observe a major breakthrough in bowel function improvement.
Overall, Lactobacillus gasseri may help relieve some symptoms associated with functional constipation.
9
We examined whether synbiotics, which include Lactobacillus rhamnosus and other beneficial bacteria, help relieve functional constipation in children aged 4 to 18. In a controlled study, one group received synbiotics while the other received a placebo for four weeks.
At the end of the treatment, we saw a significant improvement in defecation frequency and abdominal pain in the synbiotic group compared to the placebo group. In fact, two-thirds of children using synbiotics reported complete relief, highlighting their effectiveness.
At the end of the treatment, we saw a significant improvement in defecation frequency and abdominal pain in the synbiotic group compared to the placebo group. In fact, two-thirds of children using synbiotics reported complete relief, highlighting their effectiveness.
7
We examined how lactobacillus, a type of beneficial bacteria, might help alleviate constipation and other digestive system issues. The review of existing research presented evidence that lactobacillus works through several mechanisms, like producing helpful metabolites and improving gut microbiome balance.
Although it showed potential to aid with constipation, it is important to note that its effectiveness can vary based on the specific strain used. There is still more research needed to fully understand its benefits for other digestive problems, but we see promise in its role as a supporting treatment option.
Although it showed potential to aid with constipation, it is important to note that its effectiveness can vary based on the specific strain used. There is still more research needed to fully understand its benefits for other digestive problems, but we see promise in its role as a supporting treatment option.
References
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- Guo K, Tang Y, Yang T, Yan Y. Massa Medicata Fermentata treated spleen deficiency constipation by mediating intestinal microbiota and serum peptide. Front Cell Infect Microbiol. 2025;15:1556915. doi:10.3389/fcimb.2025.1556915
- Li F, Wu D, Ma K, Wei T, Wu J, et al. Effect of dietary supplementation of Bacillus subtilis QST 713 on constipation, reproductive performance and offspring growth performance of sows. Anim Reprod Sci. 2025;274:107785. doi:10.1016/j.anireprosci.2025.107785
- Zhu S, Yu Q, Xue Y, Li J, Huang Y, et al. CCFM1163 alleviates cathartic colon by activating the BDNF-TrkB-PLC/IP pathway to reconstruct the intestinal nerve and barrier. Food Funct. 2025;16:2057. doi:10.1039/d4fo05835f
- Liu TH, Chen GL, Lin CH, Tsai TY, Cheng MC. TWK10 relieves loperamide-induced constipation in rats fed a high-fat diet modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota. Food Funct. 2025;16:181. doi:10.1039/d4fo02270j
- Zhao B, Wang Y, Wang S, Mu G, Wu X. Mechanism analysis of the differences in relieving constipation in a Balb/c constipation model mouse fed human milk probiotics or fermented milk. J Sci Food Agric. 2025;105:2594. doi:10.1002/jsfa.14032
- Zhang X, Jia Y, Li X, Wang X, Li L, et al. Effects of complex probiotics on intestinal function and its regulatory mechanism in patients with constipation. Benef Microbes. 2024;16:35. doi:10.1163/18762891-bja00039
- Tanihiro R, Yuki M, Sakano K, Sasai M, Sawada D, et al. Effects of Heat-Treated CP790-Fermented Milk on Gastrointestinal Health in Healthy Adults: A Randomized Double-Blind Placebo-Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16142191
- Yang WC, Zeng BS, Liang CS, Hsu CW, Su KP, et al. Efficacy and acceptability of different probiotic products plus laxatives for pediatric functional constipation: a network meta-analysis of randomized controlled trials. Eur J Pediatr. 2024;183:3531. doi:10.1007/s00431-024-05568-6
- Han Y, Zhou Y, Xu X, Chen S, Zhang S, et al. Improvement of Post-Surgery Constipation in Patients with Fractures by JYLR-127: A Single-Blind Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16101505
- Zhang C, Wang L, Liu X, Wang G, Guo X, et al. Different microbial ecological agents change the composition of intestinal microbiota and the levels of SCFAs in mice to alleviate loperamide-induced constipation. Benef Microbes. 2024;15:311. doi:10.1163/18762891-bja00011
- Tyrsin OY, Tyrsin DY, Nemenov DG, Ruzov AS, Odintsova VE, et al. Effect of Lactobacillus reuteri NCIMB 30351 drops on symptoms of infantile functional gastrointestinal disorders and gut microbiota in early infants: Results from a randomized, placebo-controlled clinical trial. Eur J Pediatr. 2024;183:2311. doi:10.1007/s00431-024-05473-y
- Yang C, Hu T, Xue X, Su X, Zhang X, et al. Multi-omics analysis of fecal microbiota transplantation's impact on functional constipation and comorbid depression and anxiety. BMC Microbiol. 2023;23:389. doi:10.1186/s12866-023-03123-1
- Cheng S, Li B, Ding Y, Hou B, Hung W, et al. The probiotic fermented milk of Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 alleviates constipation via improving gastrointestinal motility and gut microbiota. J Dairy Sci. 2024;107:1857. doi:10.3168/jds.2023-24154
- Peng Y, Ma Y, Luo Z, Jiang Y, Xu Z, et al. in digestive system diseases: focus on clinical trials and mechanisms. Front Cell Infect Microbiol. 2023;13:1254198. doi:10.3389/fcimb.2023.1254198
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- Xia T, Huang F, Yun F, Liu Y, Wang T, et al. LRJ-1 alleviates constipation through promoting gut -derived γ-aminobutyric acid production. Curr Res Food Sci. 2024;9:100924. doi:10.1016/j.crfs.2024.100924
- Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x
- Cheng S, Cui H, Zhang J, Wang Q, Duan Z. Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice. Sci Rep. 2024;14:1131. doi:10.1038/s41598-024-51497-7
- Jeong JJ, Ganesan R, Jin YJ, Park HJ, Min BH, et al. Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats. Front Microbiol. 2023;14:1174968. doi:10.3389/fmicb.2023.1174968
- Lai H, Li Y, He Y, Chen F, Mi B, et al. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes. 2023;15:2197837. doi:10.1080/19490976.2023.2197837
- Gu Y, Qin X, Zhou G, Wang C, Mu C, et al. GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota. Food Funct. 2022;13:12144. doi:10.1039/d2fo01900k
- Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
- Wang J, Yin L, Zheng W, Shi S, Hao W, et al. Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae. World J Microbiol Biotechnol. 2022;38:222. doi:10.1007/s11274-022-03409-y
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
- Rodríguez Arreola A, Solís Pacheco JR, Lacroix M, Balcazar López E, Navarro Hernández RE, et al. In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder. Nutr Hosp. 2021;38:152. doi:10.20960/nh.03335
- Reyna-Figueroa J, Bejarano-Juvera AA, García-Parra C, Barrón-Calvillo EE, Queipo-Garcia GE, et al. Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2021;43:e457. doi:10.1097/MPH.0000000000001956
- Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, Galindo-Delgado P, Contreras-Ochoa C, et al. Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients With Acute Leukemia. J Pediatr Hematol Oncol. 2019;41:468. doi:10.1097/MPH.0000000000001497
- Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. doi:10.3390/nu11040886
- Baştürk A, Artan R, Atalay A, Yılmaz A. Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study. Turk J Gastroenterol. 2017;28:388. doi:10.5152/tjg.2017.17097
- Wojtyniak K, Horvath A, Dziechciarz P, Szajewska H. Lactobacillus casei rhamnosus Lcr35 in the Management of Functional Constipation in Children: A Randomized Trial. J Pediatr. 2017;184:101. doi:10.1016/j.jpeds.2017.01.068
- Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015. doi:10.1002/14651858.CD004827.pub4
- Roos S, Dahlgren AL, Mao YK, Pallin A, Stanisz AM, et al. Therapeutic Value of Lactobacillus gasseri 345A in Chronic Constipation. Neurogastroenterol Motil. 2025. doi:10.1111/nmo.70012
