Overview
Top Medical Research Studies
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Interestingly, LP-HFY11 also promoted positive changes in intestinal health and increased certain beneficial substances in the bloodstream, suggesting it could serve as an effective probiotic for constipation management. There appears to be promising potential for LP-HFY11's use in both the food and pharmaceutical industries.
Most Useful Reviews
Medical Researches
- All Researches
The findings revealed that CCFM1163 enhances the expression of brain-derived neurotrophic factor (BDNF), which activates a key signaling pathway, helping to restore gut health. As a result, it significantly improved intestinal function, offering hope for those suffering from this condition.
Notably, one agent, PE0401, showed a better ability to alleviate constipation symptoms by enhancing gut health and reducing inflammation. The results suggest that probiotics can play a positive role in managing constipation.
Over 14 days, we found that this probiotic mix enhanced gastrointestinal function by boosting the secretion of important gut hormones and increasing beneficial bacteria while reducing harmful ones.
Our findings suggest this fermented milk could be a useful approach to managing constipation and improving gut health.
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
User Reviews
- All Reviews
- Positive Reviews
- Negative Reviews
Frequently Asked Questions
Constipation is a common condition characterized by infrequent bowel movements or difficulty passing stools. It is typically defined as having fewer than three bowel movements per week, leading to hard, dry stools that are painful or difficult to expel. This condition can be caused by a variety of factors, including diet, dehydration, lack of physical activity, and certain medications. Stress and lifestyle changes can also contribute, making it essential for individuals to identify the root causes of their constipation for effective relief.
To alleviate constipation, it’s recommended to increase fiber intake by consuming more fruits, vegetables, whole grains, and legumes, as well as ensuring adequate hydration throughout the day. Regular exercise can also promote healthy bowel function. If over-the-counter solutions such as fiber supplements or laxatives aren't effective, it's advisable to consult a healthcare provider, as chronic constipation can lead to complications and indicate underlying health issues. Keeping a consistent eating and bathroom schedule can also help regulate bowel movements.
Lactobacillus is a genus of bacteria that plays a crucial role in the fermentation of various foods and is found naturally in the human gut. Known for their probiotic properties, strains of Lactobacillus are commonly utilized in the production of yogurt, sauerkraut, and other fermented products. They are characterized by their rod-shaped structure and ability to convert sugars into lactic acid, which not only helps preserve food but also contributes to the tangy flavor of fermented foods.
In addition to their culinary uses, Lactobacillus bacteria can offer several health benefits. They are known to support gut health by enhancing the balance of beneficial bacteria in the microbiome, potentially aiding in digestion and alleviating symptoms of issues like irritable bowel syndrome (IBS). Regular consumption of Lactobacillus-containing foods or supplements may also bolster the immune system and improve overall digestive health. With a growing interest in gut health, Lactobacillus remains a key player in both dietary and therapeutic contexts.
Recent research suggests that Lactobacillus, a type of probiotic, may help alleviate constipation in some individuals. Probiotics like Lactobacillus are beneficial bacteria that contribute to gut health, and studies have shown that they can improve bowel movement frequency and stool consistency. By enhancing the balance of gut flora, these probiotics may help facilitate digestion and promote regularity. Specific strains of Lactobacillus, such as Lactobacillus rhamnosus and Lactobacillus reuteri, have demonstrated positive effects in clinical trials, potentially making them a good option for those struggling with constipation.
However, results can vary from person to person, and Lactobacillus may not work for everyone. It's important to consider other lifestyle factors, such as diet and hydration, which play a crucial role in digestive health. If you're considering incorporating Lactobacillus into your routine to help with constipation, it's recommended to look for high-quality supplements or probiotic-rich foods like yogurt or kefir. As always, consulting with a healthcare professional before starting any new supplement is advisable to ensure it's appropriate for your individual health needs.
Based on user reviews, many individuals start to notice improvements in their constipation symptoms within a few days to a couple of weeks of regular use. For example, one user mentioned significant improvement in bowel movements after they began taking the supplement, stating that both constipation and diarrhea decreased considerably (Read Review). Another user noted that after a few weeks of daily consumption, they experienced reduced stomach discomfort and more stable digestion (Read Review).
The timing for seeing results can vary from person to person, as highlighted by the feedback from users who reported different experiences. Some users have indicated that consistent daily intake is key to achieving effective results for digestion and regularity, with one stating it has been the best solution for their constipation (Read Review). Overall, while many users report quick results, it may take some individuals a bit longer to fully benefit from this supplement.
Numerous studies indicate that various probiotic strains, particularly Lactobacillus, can effectively alleviate constipation. A recent study involving the probiotic CCFM1163 found that it improved gut nerve and barrier functions in mouse models of slow-transit constipation, leading to significant enhancements in intestinal function [4]. Furthermore, research has shown that Lactobacillus strains, such as Lacticaseibacillus rhamnosus, improve bowel activities in both humans and animal models, suggesting that these probiotics play a vital role in enhancing gut health and reducing symptoms related to constipation [18].
Insights from another study indicated that heat-treated fermented milk could improve stool consistency and reduce straining during defecation in healthy adults [1]. Although the exact mechanisms are still being explored, most studies point towards these probiotics fostering a healthier gut microbiota, which can contribute positively to alleviating constipation symptoms. However, it's important to note that individual responses can vary, and additional research may be necessary to confirm these findings across broader populations [15]. Overall, the existing evidence is promising, positioning probiotics as a beneficial option for constipation management.
Based on user reviews, many individuals have reported notable improvements in their digestive symptoms after incorporating this probiotic supplement into their routine. One user shared that after taking the product, both constipation and diarrhea significantly diminished, leading to marked improvements in their bowel movements (Read Review). Another reviewer mentioned that consistent use resulted in reduced bloating and abdominal pain, and they observed better overall digestion and relief from constipation (Read Review).
Moreover, several parents have noted positive results in their children, reporting that the supplement helped alleviate their kids' constipation and improved their mood and overall health (Read Review). Consistent usage appears to be a common theme among those who have experienced benefits, with users advising that taking the supplement daily is key for optimal results (Read Review). While these anecdotes showcase the potential effectiveness of this probiotic in alleviating digestive issues, it is essential to bear in mind that individual results may vary, and what works well for one person may not have the same impact on another.
Based on user reviews, many individuals have successfully combined this probiotic supplement with other supplements to enhance their strategy for managing constipation. For instance, one user shared that they take the probiotic daily and have found it to be the best solution for their constipation, highlighting the need for consistent use to achieve optimal results (Read Review). Another reviewer indicated a holistic approach, noting that their entire family uses the product and sees improvements in digestion and reduced bloating (Read Review).
Moreover, several parents reported positive outcomes when giving the supplement to their children, addressing constipation effectively while also stating that it improved their children's moods (Read Review). This suggests that combining this supplement with other family-friendly practices can yield comprehensive digestive support. Overall, users agree that integrating this probiotic into one’s daily routine—sometimes along with other supplements—may significantly benefit those struggling with constipation.
The optimal dose for Lactobacillus in treating constipation isn't universally defined, but research indicates that various strains exhibit beneficial effects at different levels. For example, a study involving Lactobacillus rhamnosus (LRJ-1) showed significant improvements in constipation when appropriate dosages were administered, leading to increased gut health markers and better fecal properties [17]. Another examination focused on Lactobacillus rhamnosus IDCC 3201 revealed enhancements in bowel activities and discomfort relief over an eight-week treatment period [18].
It's important to note that while specific probiotic strains may show promise, the effectiveness can vary based on dosage and individual patient responses. In general, higher doses of probiotics might lead to more significant outcomes; however, precise recommendations may depend on ongoing research and clinical findings. Overall, consulting a healthcare provider can offer tailored guidance on the appropriate dosage of Lactobacillus for individuals dealing with constipation.
The findings revealed that CCFM1163 enhances the expression of brain-derived neurotrophic factor (BDNF), which activates a key signaling pathway, helping to restore gut health. As a result, it significantly improved intestinal function, offering hope for those suffering from this condition.
After eight weeks of treatment, the probiotic group reported significant improvements in bowel activities and discomfort linked to constipation. Notably, symptoms like abdominal bloating also improved.
Our findings suggest that this probiotic might help enhance gut health by promoting beneficial microbes and their metabolites.
Although it showed potential to aid with constipation, it is important to note that its effectiveness can vary based on the specific strain used. There is still more research needed to fully understand its benefits for other digestive problems, but we see promise in its role as a supporting treatment option.
We also found that the beneficial impact of LRJ-1 was linked to the growth of specific intestinal bacteria and the activation of certain nerve pathways in the gut. While these findings are promising, they confirm the potential of LRJ-1 in addressing constipation through its influence on gut health.
References
- Tan F, Kong CS. Inhibitory Effect of HFY11 on Compound Diphenoxylate-Induced Constipation in Mice. Biomolecules. 2025;15. doi:10.3390/biom15030358
- Guo K, Tang Y, Yang T, Yan Y. Massa Medicata Fermentata treated spleen deficiency constipation by mediating intestinal microbiota and serum peptide. Front Cell Infect Microbiol. 2025;15:1556915. doi:10.3389/fcimb.2025.1556915
- Li F, Wu D, Ma K, Wei T, Wu J, et al. Effect of dietary supplementation of Bacillus subtilis QST 713 on constipation, reproductive performance and offspring growth performance of sows. Anim Reprod Sci. 2025;274:107785. doi:10.1016/j.anireprosci.2025.107785
- Zhu S, Yu Q, Xue Y, Li J, Huang Y, et al. CCFM1163 alleviates cathartic colon by activating the BDNF-TrkB-PLC/IP pathway to reconstruct the intestinal nerve and barrier. Food Funct. 2025;16:2057. doi:10.1039/d4fo05835f
- Liu TH, Chen GL, Lin CH, Tsai TY, Cheng MC. TWK10 relieves loperamide-induced constipation in rats fed a high-fat diet modulating enteric neurotransmitters, short-chain fatty acids and gut microbiota. Food Funct. 2025;16:181. doi:10.1039/d4fo02270j
- Zhao B, Wang Y, Wang S, Mu G, Wu X. Mechanism analysis of the differences in relieving constipation in a Balb/c constipation model mouse fed human milk probiotics or fermented milk. J Sci Food Agric. 2025;105:2594. doi:10.1002/jsfa.14032
- Zhang X, Jia Y, Li X, Wang X, Li L, et al. Effects of complex probiotics on intestinal function and its regulatory mechanism in patients with constipation. Benef Microbes. 2024;16:35. doi:10.1163/18762891-bja00039
- Tanihiro R, Yuki M, Sakano K, Sasai M, Sawada D, et al. Effects of Heat-Treated CP790-Fermented Milk on Gastrointestinal Health in Healthy Adults: A Randomized Double-Blind Placebo-Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16142191
- Yang WC, Zeng BS, Liang CS, Hsu CW, Su KP, et al. Efficacy and acceptability of different probiotic products plus laxatives for pediatric functional constipation: a network meta-analysis of randomized controlled trials. Eur J Pediatr. 2024;183:3531. doi:10.1007/s00431-024-05568-6
- Han Y, Zhou Y, Xu X, Chen S, Zhang S, et al. Improvement of Post-Surgery Constipation in Patients with Fractures by JYLR-127: A Single-Blind Randomized Controlled Trial. Nutrients. 2024;16. doi:10.3390/nu16101505
- Zhang C, Wang L, Liu X, Wang G, Guo X, et al. Different microbial ecological agents change the composition of intestinal microbiota and the levels of SCFAs in mice to alleviate loperamide-induced constipation. Benef Microbes. 2024;15:311. doi:10.1163/18762891-bja00011
- Tyrsin OY, Tyrsin DY, Nemenov DG, Ruzov AS, Odintsova VE, et al. Effect of Lactobacillus reuteri NCIMB 30351 drops on symptoms of infantile functional gastrointestinal disorders and gut microbiota in early infants: Results from a randomized, placebo-controlled clinical trial. Eur J Pediatr. 2024;183:2311. doi:10.1007/s00431-024-05473-y
- Yang C, Hu T, Xue X, Su X, Zhang X, et al. Multi-omics analysis of fecal microbiota transplantation's impact on functional constipation and comorbid depression and anxiety. BMC Microbiol. 2023;23:389. doi:10.1186/s12866-023-03123-1
- Cheng S, Li B, Ding Y, Hou B, Hung W, et al. The probiotic fermented milk of Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 alleviates constipation via improving gastrointestinal motility and gut microbiota. J Dairy Sci. 2024;107:1857. doi:10.3168/jds.2023-24154
- Peng Y, Ma Y, Luo Z, Jiang Y, Xu Z, et al. in digestive system diseases: focus on clinical trials and mechanisms. Front Cell Infect Microbiol. 2023;13:1254198. doi:10.3389/fcimb.2023.1254198
- Huh KY, Chung WK, Park J, Lee S, Kim MG, et al. Feasibility study for a fully decentralized clinical trial in participants with functional constipation symptoms. Clin Transl Sci. 2023;16:2177. doi:10.1111/cts.13617
- Xia T, Huang F, Yun F, Liu Y, Wang T, et al. LRJ-1 alleviates constipation through promoting gut -derived γ-aminobutyric acid production. Curr Res Food Sci. 2024;9:100924. doi:10.1016/j.crfs.2024.100924
- Kwon H, Nam EH, Kim H, Jo H, Bang WY, et al. Effect of Lacticaseibacillus rhamnosus IDCC 3201 on irritable bowel syndrome with constipation: a randomized, double-blind, and placebo-controlled trial. Sci Rep. 2024;14:22384. doi:10.1038/s41598-024-72887-x
- Cheng S, Cui H, Zhang J, Wang Q, Duan Z. Probiotic potential of Lacticaseibacillus rhamnosus VHProbi M15 on sucralfate-induced constipation in mice. Sci Rep. 2024;14:1131. doi:10.1038/s41598-024-51497-7
- Jeong JJ, Ganesan R, Jin YJ, Park HJ, Min BH, et al. Multi-strain probiotics alleviate loperamide-induced constipation by adjusting the microbiome, serotonin, and short-chain fatty acids in rats. Front Microbiol. 2023;14:1174968. doi:10.3389/fmicb.2023.1174968
- Lai H, Li Y, He Y, Chen F, Mi B, et al. Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial. Gut Microbes. 2023;15:2197837. doi:10.1080/19490976.2023.2197837
- Gu Y, Qin X, Zhou G, Wang C, Mu C, et al. GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota. Food Funct. 2022;13:12144. doi:10.1039/d2fo01900k
- Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
- Wang J, Yin L, Zheng W, Shi S, Hao W, et al. Lactobacillus rhamnosus GG normalizes gut dysmotility induced by environmental pollutants via affecting serotonin level in zebrafish larvae. World J Microbiol Biotechnol. 2022;38:222. doi:10.1007/s11274-022-03409-y
- Petersen AØ, Jokinen M, Plichta DR, Liebisch G, Gronwald W, et al. Cytokine-specific autoantibodies shape the gut microbiome in autoimmune polyendocrine syndrome type 1. J Allergy Clin Immunol. 2021;148:876. doi:10.1016/j.jaci.2021.03.025
- Rodríguez Arreola A, Solís Pacheco JR, Lacroix M, Balcazar López E, Navarro Hernández RE, et al. In vivo assessment and characterization of lactic acid bacteria with probiotic profile isolated from human milk powder. Nutr Hosp. 2021;38:152. doi:10.20960/nh.03335
- Reyna-Figueroa J, Bejarano-Juvera AA, García-Parra C, Barrón-Calvillo EE, Queipo-Garcia GE, et al. Decrease of Postchemotherapy Complications With the Use of Probiotics in Children With Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2021;43:e457. doi:10.1097/MPH.0000000000001956
- Reyna-Figueroa J, Barrón-Calvillo E, García-Parra C, Galindo-Delgado P, Contreras-Ochoa C, et al. Probiotic Supplementation Decreases Chemotherapy-induced Gastrointestinal Side Effects in Patients With Acute Leukemia. J Pediatr Hematol Oncol. 2019;41:468. doi:10.1097/MPH.0000000000001497
- Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, et al. Effects of and on Gut Microbiota in Patients with Lactose Intolerance and Persisting Functional Gastrointestinal Symptoms: A Randomised, Double-Blind, Cross-Over Study. Nutrients. 2019;11. doi:10.3390/nu11040886
- Baştürk A, Artan R, Atalay A, Yılmaz A. Investigation of the efficacy of synbiotics in the treatment of functional constipation in children: a randomized double-blind placebo-controlled study. Turk J Gastroenterol. 2017;28:388. doi:10.5152/tjg.2017.17097
- Wojtyniak K, Horvath A, Dziechciarz P, Szajewska H. Lactobacillus casei rhamnosus Lcr35 in the Management of Functional Constipation in Children: A Randomized Trial. J Pediatr. 2017;184:101. doi:10.1016/j.jpeds.2017.01.068
- Goldenberg JZ, Lytvyn L, Steurich J, Parkin P, Mahant S, et al. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2015. doi:10.1002/14651858.CD004827.pub4
