Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.3
USERS' SCORE
Good
Based on 3 Reviews
8.5
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Magnesium (from 2,000 mg magnesium lysinate glycinate chelate) (Albion®)
200 mg
48%
Top Medical Research Studies
9
We investigated the potential benefits of magnesium isoglycyrrhizinate in treating colitis induced by dextran sulfate sodium (DSS). Our findings suggest that magnesium isoglycyrrhizinate can effectively alleviate both acute and chronic symptoms of colitis.
The treatment helped reduce inflammation by lowering the number of immune cells in the affected areas and decreasing levels of inflammatory cytokines. Additionally, we noted it significantly reduced reactive oxygen species (ROS) levels and mitigated the damage to the gut barrier associated with DSS treatment.
Another key observation was the treatment's ability to decrease colonic fibrosis, a common complication of IBD. Overall, these results indicate that magnesium isoglycyrrhizinate shows promise in managing intestinal inflammation and could be beneficial for people suffering from inflammatory bowel disease in clinical settings.
The treatment helped reduce inflammation by lowering the number of immune cells in the affected areas and decreasing levels of inflammatory cytokines. Additionally, we noted it significantly reduced reactive oxygen species (ROS) levels and mitigated the damage to the gut barrier associated with DSS treatment.
Another key observation was the treatment's ability to decrease colonic fibrosis, a common complication of IBD. Overall, these results indicate that magnesium isoglycyrrhizinate shows promise in managing intestinal inflammation and could be beneficial for people suffering from inflammatory bowel disease in clinical settings.
Read More
9
We examined the impact of magnesium on colitis, particularly focusing on how magnesium supplementation could improve gut health. In a controlled murine model of colitis, induced by dextran sodium sulfate, we monitored several factors, including magnesium levels in the blood, weight changes, and the consistency of feces.
Our exploration revealed that adding magnesium to the diet led to a richer gut microbiota in mice with colitis. Specifically, we observed an increase in beneficial bacteria, while the levels of harmful bacteria, such as Enterobacteriaceae, were reduced.
Furthermore, the analysis suggested that when magnesium was supplemented, there was enhanced biosynthetic activity and vital DNA repair processes occurring in the gut. Meanwhile, low magnesium levels seemed to support more harmful, catabolic processes.
These findings indicate that magnesium supplementation may be a helpful and cost-effective approach to alleviate symptoms of colitis and support overall gut microbiome health in individuals suffering from inflammatory bowel diseases.
Our exploration revealed that adding magnesium to the diet led to a richer gut microbiota in mice with colitis. Specifically, we observed an increase in beneficial bacteria, while the levels of harmful bacteria, such as Enterobacteriaceae, were reduced.
Furthermore, the analysis suggested that when magnesium was supplemented, there was enhanced biosynthetic activity and vital DNA repair processes occurring in the gut. Meanwhile, low magnesium levels seemed to support more harmful, catabolic processes.
These findings indicate that magnesium supplementation may be a helpful and cost-effective approach to alleviate symptoms of colitis and support overall gut microbiome health in individuals suffering from inflammatory bowel diseases.
Read More
9
We explored the potential benefits of magnesium for people suffering from inflammatory bowel disease (IBD), particularly how its availability might influence colitis. The study involved measuring magnesium levels in IBD patients and investigating the effects of dietary magnesium in mice with colitis induced by dextran sodium sulfate (DSS).
Our findings revealed that a significant number of IBD patients had low magnesium levels, which were linked to increased disease activity. In the murine model, those on a magnesium-deficient diet experienced exacerbated colitis symptoms, highlighting how this deficiency can worsen inflammation and complicate the recovery of intestinal health.
However, we observed that supplementing magnesium not only improved magnesium levels but also aid in restoring the intestinal barrier, particularly by enhancing the expression of TRPM6 channels in the gut. This suggests that magnesium could be a safe and effective addition to treatment strategies for managing colitis and might help restore normal gut function.
Our findings revealed that a significant number of IBD patients had low magnesium levels, which were linked to increased disease activity. In the murine model, those on a magnesium-deficient diet experienced exacerbated colitis symptoms, highlighting how this deficiency can worsen inflammation and complicate the recovery of intestinal health.
However, we observed that supplementing magnesium not only improved magnesium levels but also aid in restoring the intestinal barrier, particularly by enhancing the expression of TRPM6 channels in the gut. This suggests that magnesium could be a safe and effective addition to treatment strategies for managing colitis and might help restore normal gut function.
Read More
Most Useful Reviews
9
Normalised blood pressure
This magnesium is incredibly effective! My husband has a consistent need for magnesium and tried many forms before finding this one. The results were immediate; his previously high blood pressure returned to normal, allowing us to reduce his dosage by half. Despite his tendency for loose stools and his ulcerative condition, he experienced no adverse effects. Though the tablets are substantial, they are easy to swallow, and I highly recommend this product.
Read More
7.5
Reduced Colitis symptoms
4 people found this helpful
After trying magnesium oxide and citrate with little effect, I found this magnesium to be the best. Over a couple of weeks, my leg cramps subsided, and my spastic colitis showed less activity. Additionally, my headaches stopped. It seems I was truly lacking magnesium in my body.
Read More
9
No side effects
Magnesium is essential for our wellbeing! After a week, my sleep improved remarkably. As someone with ulcerative gastritis, I often experience stomach pain from medications, but this magnesium caused no discomfort or adverse effects. It aids in various bodily syntheses, so I believe regular intake is beneficial.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 7 Researches
8.3
- All Researches
9
We examined the impact of magnesium on colitis, particularly focusing on how magnesium supplementation could improve gut health. In a controlled murine model of colitis, induced by dextran sodium sulfate, we monitored several factors, including magnesium levels in the blood, weight changes, and the consistency of feces.
Our exploration revealed that adding magnesium to the diet led to a richer gut microbiota in mice with colitis. Specifically, we observed an increase in beneficial bacteria, while the levels of harmful bacteria, such as Enterobacteriaceae, were reduced.
Furthermore, the analysis suggested that when magnesium was supplemented, there was enhanced biosynthetic activity and vital DNA repair processes occurring in the gut. Meanwhile, low magnesium levels seemed to support more harmful, catabolic processes.
These findings indicate that magnesium supplementation may be a helpful and cost-effective approach to alleviate symptoms of colitis and support overall gut microbiome health in individuals suffering from inflammatory bowel diseases.
Our exploration revealed that adding magnesium to the diet led to a richer gut microbiota in mice with colitis. Specifically, we observed an increase in beneficial bacteria, while the levels of harmful bacteria, such as Enterobacteriaceae, were reduced.
Furthermore, the analysis suggested that when magnesium was supplemented, there was enhanced biosynthetic activity and vital DNA repair processes occurring in the gut. Meanwhile, low magnesium levels seemed to support more harmful, catabolic processes.
These findings indicate that magnesium supplementation may be a helpful and cost-effective approach to alleviate symptoms of colitis and support overall gut microbiome health in individuals suffering from inflammatory bowel diseases.
Read More
9
We investigated the potential benefits of magnesium isoglycyrrhizinate in treating colitis induced by dextran sulfate sodium (DSS). Our findings suggest that magnesium isoglycyrrhizinate can effectively alleviate both acute and chronic symptoms of colitis.
The treatment helped reduce inflammation by lowering the number of immune cells in the affected areas and decreasing levels of inflammatory cytokines. Additionally, we noted it significantly reduced reactive oxygen species (ROS) levels and mitigated the damage to the gut barrier associated with DSS treatment.
Another key observation was the treatment's ability to decrease colonic fibrosis, a common complication of IBD. Overall, these results indicate that magnesium isoglycyrrhizinate shows promise in managing intestinal inflammation and could be beneficial for people suffering from inflammatory bowel disease in clinical settings.
The treatment helped reduce inflammation by lowering the number of immune cells in the affected areas and decreasing levels of inflammatory cytokines. Additionally, we noted it significantly reduced reactive oxygen species (ROS) levels and mitigated the damage to the gut barrier associated with DSS treatment.
Another key observation was the treatment's ability to decrease colonic fibrosis, a common complication of IBD. Overall, these results indicate that magnesium isoglycyrrhizinate shows promise in managing intestinal inflammation and could be beneficial for people suffering from inflammatory bowel disease in clinical settings.
Read More
9
We explored the potential benefits of magnesium for people suffering from inflammatory bowel disease (IBD), particularly how its availability might influence colitis. The study involved measuring magnesium levels in IBD patients and investigating the effects of dietary magnesium in mice with colitis induced by dextran sodium sulfate (DSS).
Our findings revealed that a significant number of IBD patients had low magnesium levels, which were linked to increased disease activity. In the murine model, those on a magnesium-deficient diet experienced exacerbated colitis symptoms, highlighting how this deficiency can worsen inflammation and complicate the recovery of intestinal health.
However, we observed that supplementing magnesium not only improved magnesium levels but also aid in restoring the intestinal barrier, particularly by enhancing the expression of TRPM6 channels in the gut. This suggests that magnesium could be a safe and effective addition to treatment strategies for managing colitis and might help restore normal gut function.
Our findings revealed that a significant number of IBD patients had low magnesium levels, which were linked to increased disease activity. In the murine model, those on a magnesium-deficient diet experienced exacerbated colitis symptoms, highlighting how this deficiency can worsen inflammation and complicate the recovery of intestinal health.
However, we observed that supplementing magnesium not only improved magnesium levels but also aid in restoring the intestinal barrier, particularly by enhancing the expression of TRPM6 channels in the gut. This suggests that magnesium could be a safe and effective addition to treatment strategies for managing colitis and might help restore normal gut function.
Read More
8
We encountered a rare and intriguing case involving a 75-year-old woman who presented with impaired consciousness linked to hypermagnesemia—a significant increase in magnesium levels. The connection we observed was particularly striking, as this situation arose in the absence of magnesium supplementation, drawing our attention to the potential role of severe bowel dysfunction in increasing magnesium concentrations.
The patient exhibited symptoms like a distended abdomen, hypotension, and cognitive impairment, all pointing toward serious underlying issues. Through abdominal imaging, we found evidence of fecal impaction, leading to what is known as stercoral colitis. The elevated magnesium levels truly puzzled us, especially since there was no history of magnesium administration, prompting us to consider that severe bowel dysfunction could independently contribute to hypermagnesemia.
After treatment, including calcium administration and measures to address the fecal impaction, the patient's magnesium levels and consciousness improved. This case illustrates that magnesium levels can rise dangerously high with severe intestinal issues without direct magnesium intake, suggesting a complex interplay between the gut and electrolyte balance that merits further investigation.
The patient exhibited symptoms like a distended abdomen, hypotension, and cognitive impairment, all pointing toward serious underlying issues. Through abdominal imaging, we found evidence of fecal impaction, leading to what is known as stercoral colitis. The elevated magnesium levels truly puzzled us, especially since there was no history of magnesium administration, prompting us to consider that severe bowel dysfunction could independently contribute to hypermagnesemia.
After treatment, including calcium administration and measures to address the fecal impaction, the patient's magnesium levels and consciousness improved. This case illustrates that magnesium levels can rise dangerously high with severe intestinal issues without direct magnesium intake, suggesting a complex interplay between the gut and electrolyte balance that merits further investigation.
Read More
8
We conducted a case-control study to explore how dietary magnesium intake relates to ulcerative colitis (UC). By analyzing 109 UC patients alongside 218 matched individuals without the condition, we aimed to uncover if magnesium could play a protective role against UC.
Participants reported their dietary intake using a comprehensive Food Frequency Questionnaire that allowed us to assess their magnesium consumption levels. Our findings revealed that those in the highest intake group were significantly less likely to have UC compared to those in the lowest group, showing an odds ratio of 0.32 in the unadjusted model.
After accounting for various potential confounding factors, the association remained strong, with an adjusted odds ratio of 0.30. This suggests that higher magnesium intake may be linked to a lower risk of developing ulcerative colitis, highlighting the importance of a magnesium-rich diet.
However, while these results are promising, we acknowledge the need for further research to fully understand the role of magnesium in preventing UC.
Participants reported their dietary intake using a comprehensive Food Frequency Questionnaire that allowed us to assess their magnesium consumption levels. Our findings revealed that those in the highest intake group were significantly less likely to have UC compared to those in the lowest group, showing an odds ratio of 0.32 in the unadjusted model.
After accounting for various potential confounding factors, the association remained strong, with an adjusted odds ratio of 0.30. This suggests that higher magnesium intake may be linked to a lower risk of developing ulcerative colitis, highlighting the importance of a magnesium-rich diet.
However, while these results are promising, we acknowledge the need for further research to fully understand the role of magnesium in preventing UC.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Normalised blood pressure
This magnesium is incredibly effective! My husband has a consistent need for magnesium and tried many forms before finding this one. The results were immediate; his previously high blood pressure returned to normal, allowing us to reduce his dosage by half. Despite his tendency for loose stools and his ulcerative condition, he experienced no adverse effects. Though the tablets are substantial, they are easy to swallow, and I highly recommend this product.
Read More
7.5
Reduced Colitis symptoms
4 people found this helpful
After trying magnesium oxide and citrate with little effect, I found this magnesium to be the best. Over a couple of weeks, my leg cramps subsided, and my spastic colitis showed less activity. Additionally, my headaches stopped. It seems I was truly lacking magnesium in my body.
Read More
9
No side effects
Magnesium is essential for our wellbeing! After a week, my sleep improved remarkably. As someone with ulcerative gastritis, I often experience stomach pain from medications, but this magnesium caused no discomfort or adverse effects. It aids in various bodily syntheses, so I believe regular intake is beneficial.
Read More
Frequently Asked Questions
9
No side effects
Magnesium is essential for our wellbeing! After a week, my sleep improved remarkably. As someone with ulcerative gastritis, I often experience stomach pain from medications, but this magnesium caused no discomfort or adverse effects. It aids in various bodily syntheses, so I believe regular intake is beneficial.
7.5
Reduced Colitis symptoms
4 people found this helpful
After trying magnesium oxide and citrate with little effect, I found this magnesium to be the best. Over a couple of weeks, my leg cramps subsided, and my spastic colitis showed less activity. Additionally, my headaches stopped. It seems I was truly lacking magnesium in my body.
9
Normalised blood pressure
This magnesium is incredibly effective! My husband has a consistent need for magnesium and tried many forms before finding this one. The results were immediate; his previously high blood pressure returned to normal, allowing us to reduce his dosage by half. Despite his tendency for loose stools and his ulcerative condition, he experienced no adverse effects. Though the tablets are substantial, they are easy to swallow, and I highly recommend this product.
8
We conducted a case-control study to explore how dietary magnesium intake relates to ulcerative colitis (UC). By analyzing 109 UC patients alongside 218 matched individuals without the condition, we aimed to uncover if magnesium could play a protective role against UC.
Participants reported their dietary intake using a comprehensive Food Frequency Questionnaire that allowed us to assess their magnesium consumption levels. Our findings revealed that those in the highest intake group were significantly less likely to have UC compared to those in the lowest group, showing an odds ratio of 0.32 in the unadjusted model.
After accounting for various potential confounding factors, the association remained strong, with an adjusted odds ratio of 0.30. This suggests that higher magnesium intake may be linked to a lower risk of developing ulcerative colitis, highlighting the importance of a magnesium-rich diet.
However, while these results are promising, we acknowledge the need for further research to fully understand the role of magnesium in preventing UC.
Participants reported their dietary intake using a comprehensive Food Frequency Questionnaire that allowed us to assess their magnesium consumption levels. Our findings revealed that those in the highest intake group were significantly less likely to have UC compared to those in the lowest group, showing an odds ratio of 0.32 in the unadjusted model.
After accounting for various potential confounding factors, the association remained strong, with an adjusted odds ratio of 0.30. This suggests that higher magnesium intake may be linked to a lower risk of developing ulcerative colitis, highlighting the importance of a magnesium-rich diet.
However, while these results are promising, we acknowledge the need for further research to fully understand the role of magnesium in preventing UC.
9
We examined the impact of magnesium on colitis, particularly focusing on how magnesium supplementation could improve gut health. In a controlled murine model of colitis, induced by dextran sodium sulfate, we monitored several factors, including magnesium levels in the blood, weight changes, and the consistency of feces.
Our exploration revealed that adding magnesium to the diet led to a richer gut microbiota in mice with colitis. Specifically, we observed an increase in beneficial bacteria, while the levels of harmful bacteria, such as Enterobacteriaceae, were reduced.
Furthermore, the analysis suggested that when magnesium was supplemented, there was enhanced biosynthetic activity and vital DNA repair processes occurring in the gut. Meanwhile, low magnesium levels seemed to support more harmful, catabolic processes.
These findings indicate that magnesium supplementation may be a helpful and cost-effective approach to alleviate symptoms of colitis and support overall gut microbiome health in individuals suffering from inflammatory bowel diseases.
Our exploration revealed that adding magnesium to the diet led to a richer gut microbiota in mice with colitis. Specifically, we observed an increase in beneficial bacteria, while the levels of harmful bacteria, such as Enterobacteriaceae, were reduced.
Furthermore, the analysis suggested that when magnesium was supplemented, there was enhanced biosynthetic activity and vital DNA repair processes occurring in the gut. Meanwhile, low magnesium levels seemed to support more harmful, catabolic processes.
These findings indicate that magnesium supplementation may be a helpful and cost-effective approach to alleviate symptoms of colitis and support overall gut microbiome health in individuals suffering from inflammatory bowel diseases.
9
We investigated the potential benefits of magnesium isoglycyrrhizinate in treating colitis induced by dextran sulfate sodium (DSS). Our findings suggest that magnesium isoglycyrrhizinate can effectively alleviate both acute and chronic symptoms of colitis.
The treatment helped reduce inflammation by lowering the number of immune cells in the affected areas and decreasing levels of inflammatory cytokines. Additionally, we noted it significantly reduced reactive oxygen species (ROS) levels and mitigated the damage to the gut barrier associated with DSS treatment.
Another key observation was the treatment's ability to decrease colonic fibrosis, a common complication of IBD. Overall, these results indicate that magnesium isoglycyrrhizinate shows promise in managing intestinal inflammation and could be beneficial for people suffering from inflammatory bowel disease in clinical settings.
The treatment helped reduce inflammation by lowering the number of immune cells in the affected areas and decreasing levels of inflammatory cytokines. Additionally, we noted it significantly reduced reactive oxygen species (ROS) levels and mitigated the damage to the gut barrier associated with DSS treatment.
Another key observation was the treatment's ability to decrease colonic fibrosis, a common complication of IBD. Overall, these results indicate that magnesium isoglycyrrhizinate shows promise in managing intestinal inflammation and could be beneficial for people suffering from inflammatory bowel disease in clinical settings.
9
We explored the potential benefits of magnesium for people suffering from inflammatory bowel disease (IBD), particularly how its availability might influence colitis. The study involved measuring magnesium levels in IBD patients and investigating the effects of dietary magnesium in mice with colitis induced by dextran sodium sulfate (DSS).
Our findings revealed that a significant number of IBD patients had low magnesium levels, which were linked to increased disease activity. In the murine model, those on a magnesium-deficient diet experienced exacerbated colitis symptoms, highlighting how this deficiency can worsen inflammation and complicate the recovery of intestinal health.
However, we observed that supplementing magnesium not only improved magnesium levels but also aid in restoring the intestinal barrier, particularly by enhancing the expression of TRPM6 channels in the gut. This suggests that magnesium could be a safe and effective addition to treatment strategies for managing colitis and might help restore normal gut function.
Our findings revealed that a significant number of IBD patients had low magnesium levels, which were linked to increased disease activity. In the murine model, those on a magnesium-deficient diet experienced exacerbated colitis symptoms, highlighting how this deficiency can worsen inflammation and complicate the recovery of intestinal health.
However, we observed that supplementing magnesium not only improved magnesium levels but also aid in restoring the intestinal barrier, particularly by enhancing the expression of TRPM6 channels in the gut. This suggests that magnesium could be a safe and effective addition to treatment strategies for managing colitis and might help restore normal gut function.
References
- Yanagisawa K, Mizu D, Higashi H, Miyamoto M, Nagatomo M. Impaired consciousness due to hypermagnesemia associated with stercoral colitis: report of a rare case. Int J Emerg Med. 2025;18:36. 10.1186/s12245-025-00838-y
- Sadeghi O, Khademi Z, Saneei P, Hassanzadeh-Keshteli A, Daghaghzadeh H, et al. Dietary Magnesium Intake Is Inversely Associated With Ulcerative Colitis: A Case-Control Study. Crohns Colitis 360. 2024;6:otae009. 10.1093/crocol/otae009
- Miyanaga K, Asada A, Komoto M, Ohshima Y, Morimoto H, et al. Prophylactic Administration of Magnesium Oxide Prevents Dextran Sulfate Sodium-Induced Colonic Injury in Mice. Biol Pharm Bull. 2022;45:1312. 10.1248/bpb.b22-00278
- Del Chierico F, Trapani V, Petito V, Reddel S, Pietropaolo G, et al. Dietary Magnesium Alleviates Experimental Murine Colitis through Modulation of Gut Microbiota. Nutrients. 2021;13. 10.3390/nu13124188
- Liu C, Cheng Y, Guo Y, Qian H. Magnesium-L-threonate alleviate colonic inflammation and memory impairment in chronic-plus-binge alcohol feeding mice. Brain Res Bull. 2021;174:184. 10.1016/j.brainresbull.2021.06.009
- Cui J, Li Y, Jiao C, Gao J, He Y, et al. Improvement of magnesium isoglycyrrhizinate on DSS-induced acute and chronic colitis. Int Immunopharmacol. 2021;90:107194. 10.1016/j.intimp.2020.107194
- Trapani V, Petito V, Di Agostini A, Arduini D, Hamersma W, et al. Dietary Magnesium Alleviates Experimental Murine Colitis Through Upregulation of the Transient Receptor Potential Melastatin 6 Channel. Inflamm Bowel Dis. 2018;24:2198. 10.1093/ibd/izy186
