We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
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4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
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9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
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Most Useful Reviews
10
Colic and constipation resolved
1 people found this helpful
The child immediately became calm after taking it. Both constipation and colic have disappeared.
Read More
9
Constipation alleviated
1 people found this helpful
Excellent! Initially, my constipation was very severe. After consuming this high absorption magnesium powder, my gastrointestinal functions relaxed, and the severe constipation improved noticeably.
Read More
10
Constipation disappears
An excellent version of easily digestible magnesium, I give it to my 90-year-old grandmother. She praises it, saying that her intestines work immediately, and her constipation disappears. It has a mild effect on the gastrointestinal tract and absorbs quickly. The taste isn't great, but one quickly becomes accustomed to it. I recommend it; if my review was helpful, please give it a thumbs-up!
We explored the relationship between magnesium supplementation, defecation, and cognitive performance in elite triathletes. In a carefully designed crossover trial, participants undertook cognitive tests after taking magnesium oxide and after defecation. This study highlighted an interesting potential connection between the state of our digestive system and cognitive abilities.
We found that after magnesium-induced defecation, participants completed cognitive tasks more quickly compared to when they had not defecated. Specifically, the average completion time for the cognitive test dropped significantly after defecation when magnesium was involved. While this suggests that magnesium can aid in relieving constipation, its role in improving overall cognitive function during athletics is also noteworthy.
Although we observed an increase in cognitive performance following magnesium supplementation, it’s important to note that no significant changes in blood flow or oxygen levels were detected in the brain during the test. Instead, we noted decreased oxygen levels in the digestive region, hinting at an increased demand for energy there.
Overall, our findings suggest a potential new avenue for enhancing cognitive function in athletes through magnesium to improve constipation. However, the direct effects of magnesium solely on constipation require further investigation.
Read More
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
Read More
9
Magnesium aids cancer patient care
Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial.
We conducted a randomized, double-blind trial to assess how magnesium-L-threonate, a new compound, might help relieve constipation while enhancing the pain relief effects of opioids in patients with advanced cancer. During the study, patients receiving this treatment were compared with those taking a placebo, allowing us to clearly see the differences in outcomes.
As the trial progressed, we noticed significant improvements in the group taking magnesium-L-threonate. Notably, this treatment not only helped in managing pain more effectively but also significantly alleviated opioid-induced constipation—a common side effect of opioid use. The data indicated that patients on magnesium-L-threonate required lower doses of opioids for pain management while enjoying better gastrointestinal comfort.
Overall, our findings suggest that magnesium-L-threonate is a promising option in the palliative care landscape for cancer patients, addressing both pain relief and constipation, which can greatly enhance their quality of life.
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9
Magnesium may alleviate constipation
Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
We examined the effectiveness of oral magnesium sulfate in treating chronic constipation for children with spastic cerebral palsy. In our study, 100 children received either magnesium sulfate or a placebo for one month.
After this period, we noticed significant improvements in bowel movement frequency and stool consistency in the magnesium group, while the placebo group showed minimal change.
This treatment not only alleviated constipation but also reduced the distress of painful bowel movements for both children and their mothers.
Read More
9
Effective treatment for chronic constipation
Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial.
We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
The child immediately became calm after taking it. Both constipation and colic have disappeared.
Read More
9
Constipation alleviated
1 people found this helpful
Excellent! Initially, my constipation was very severe. After consuming this high absorption magnesium powder, my gastrointestinal functions relaxed, and the severe constipation improved noticeably.
Read More
10
Constipation disappears
An excellent version of easily digestible magnesium, I give it to my 90-year-old grandmother. She praises it, saying that her intestines work immediately, and her constipation disappears. It has a mild effect on the gastrointestinal tract and absorbs quickly. The taste isn't great, but one quickly becomes accustomed to it. I recommend it; if my review was helpful, please give it a thumbs-up!
Read More
9
Effective for constipation
Great magnesium citrate is a highly absorbable form of magnesium that provides multiple health benefits, including relief from constipation and support for muscle and nerve function, heart health, and bone density. Its mild laxative effect is perfect for digestive health, and its bioavailability ensures effective replenishment of magnesium levels in the body.
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9
Constipation relief
While studying for exams, I was inactive and became constipated. Taking magnesium along with lactic acid bacteria resolved my constipation. However, a meal is necessary for optimal results. The powder turns slightly cloudy when mixed with water, and the taste is somewhat unpleasant. Overall, I found the quality satisfactory.
Constipation is a common condition characterized by infrequent bowel movements or difficulty passing stools. It is typically defined as having fewer than three bowel movements per week, leading to hard, dry stools that are painful or difficult to expel. This condition can be caused by a variety of factors, including diet, dehydration, lack of physical activity, and certain medications. Stress and lifestyle changes can also contribute, making it essential for individuals to identify the root causes of their constipation for effective relief.
To alleviate constipation, it’s recommended to increase fiber intake by consuming more fruits, vegetables, whole grains, and legumes, as well as ensuring adequate hydration throughout the day. Regular exercise can also promote healthy bowel function. If over-the-counter solutions such as fiber supplements or laxatives aren't effective, it's advisable to consult a healthcare provider, as chronic constipation can lead to complications and indicate underlying health issues. Keeping a consistent eating and bathroom schedule can also help regulate bowel movements.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium is often praised for its ability to support various bodily functions, and one of its lesser-known benefits is its potential to alleviate constipation. Magnesium acts as a natural laxative by attracting water into the intestines, which helps to soften stool and promote regular bowel movements. Various forms of magnesium supplements, such as magnesium citrate and magnesium hydroxide, are commonly used to relieve constipation. These forms are more bioavailable and have a reputation for being effective for those struggling with infrequent bowel movements.
That said, it's important to approach magnesium supplementation with care. While it can be beneficial, excessive magnesium intake can lead to adverse effects, including diarrhea and gastrointestinal discomfort. It’s always a good idea to consult with a healthcare provider or a dietitian before starting any supplementation, especially if you are considering magnesium as a treatment for constipation. They can help determine the appropriate dosage and form for your specific needs, ensuring that you reap the benefits while minimizing potential side effects.
Based on user reviews, the time frame for seeing results from this magnesium supplement for constipation can vary. Many users report experiencing a noticeable improvement relatively quickly, often within hours of taking the supplement. For instance, one user noted that their gastrointestinal function relaxed and constipation improved noticeably after consumption Read Review. Another reviewer mentioned that their grandmother felt an immediate effect, with constipation disappearing soon after taking it Read Review.
However, some users have indicated that while relief can be experienced quickly, consistent use may be required for sustained benefits. One user commented that they expected their constipation to be resolved within the first month of use, suggesting that longer-term use may be necessary to fully assess the supplement's effectiveness Read Review. In summary, while many users find relief quickly, ongoing use may enhance results and should be considered for chronic issues.
Magnesium supplements, particularly magnesium oxide and magnesium hydroxide, have shown promising results in scientific research as a treatment for constipation. A systematic review of randomised controlled trials concluded that magnesium oxide significantly increases the frequency of bowel movements and improves stool consistency, with an average increase of approximately 3.7 additional movements per week compared to placebo groups [8]. Additionally, magnesium hydroxide has been effective in acute settings, significantly reducing the time to the first bowel movement among patients recovering from acute myocardial infarction [3].
However, not all studies unanimously support magnesium's effectiveness, especially when it is combined with other treatments such as probiotics, where no significant advantages were observed [4]. While magnesium can support bowel function, it's important to note that individual responses may vary and further studies are recommended to refine its usage. Overall, the current evidence supports magnesium supplements as a valid option for managing constipation, albeit with the understanding that their efficacy can be context-dependent.
Users have reported a range of improvements in symptoms after taking this magnesium supplement, particularly concerning digestive health. Many users noted a quick and significant reduction in constipation, with one parent stating their child became calm and both constipation and colic disappeared following administration Read Review. Similarly, a user experiencing severe constipation reported noticeable relief after taking the supplement, indicating its effectiveness for rapid gastrointestinal relaxation Read Review. Other users have shared that the supplement not only alleviated constipation but also provided additional benefits such as improved sleep and reduced stress levels Read Review.
Nevertheless, individual results can vary considerably. While many experienced almost immediate benefits, a user indicated that long-term use may be necessary for sustained results, particularly noting that their initial improvement in constipation was not mirrored in their sleep quality Read Review. Additionally, some users mentioned taste discomfort and occasional laxative effects, which can influence overall satisfaction with the product Read Review. Ultimately, while anecdotal evidence suggests positive outcomes, it is important to consider that individual experiences may vary based on dosage and personal health conditions.
Users have shared various experiences when combining this magnesium supplement with other supplements to manage constipation. Notably, one user reported success when taking magnesium alongside lactic acid bacteria, stating that this combination resolved their constipation effectively, especially when taken after meals Read Review. Additionally, another reviewer mentioned mixing the magnesium supplement with another magnesium powder, which led to improved sleep and a significant reduction in constipation for their child, after initially dealing with unpleasant taste issues Read Review.
Moreover, several users noted enhanced effects on constipation when used in conjunction with other vitamins or lifestyle adjustments. For instance, one individual taking magnesium threonate in the morning and magnesium glycinate at night experienced resolved constipation, although they were still waiting for improvements in sleep and focus Read Review. Overall, combining this magnesium supplement with other supportive supplements or dietary changes seems to have yielded positive results for many users, suggesting it may be beneficial to explore such combinations for better management of constipation.
Based on user reviews, a common theme emerges regarding the effective dosage of magnesium for relieving constipation. Several users report positive outcomes when they consume magnesium regularly, particularly in powder form, and some specify taking it before bed. For instance, a user noted significant relief from severe constipation after consuming a high absorption magnesium powder, indicating its effectiveness in relaxing gastrointestinal functions Read Review. Another user mentioned the immediate efficacy of the magnesium supplement for their 90-year-old grandmother, who experienced fast relief from constipation, suggesting that smaller dosages can still be effective Read Review.
Moreover, users have indicated that consistency in taking the magnesium, often alongside meals or at specific times of the day, enhances its effectiveness. For example, a user administering magnesium to their child reported a notable reduction in constipation issues when combined with meals and taken a few hours before bed Read Review. Others have found that the magnesium works best when paired with dietary considerations, demonstrating personalized approaches based on individual needs. Overall, it appears that an effective dosage will vary, but regular consumption, either before bed or with meals, is frequently highlighted by users seeking relief from constipation.
9
Constipation alleviated
1 people found this helpful
Excellent! Initially, my constipation was very severe. After consuming this high absorption magnesium powder, my gastrointestinal functions relaxed, and the severe constipation improved noticeably.
10
Constipation disappears
An excellent version of easily digestible magnesium, I give it to my 90-year-old grandmother. She praises it, saying that her intestines work immediately, and her constipation disappears. It has a mild effect on the gastrointestinal tract and absorbs quickly. The taste isn't great, but one quickly becomes accustomed to it. I recommend it; if my review was helpful, please give it a thumbs-up!
9
Constipation resolved
1 people found this helpful
I have ADHD. I take magnesium threonate in the morning and magnesium glycinate in the evening. I've been on it for a week, but haven’t yet noticed any improvement in sleep. However, my constipation has been resolved. The expectation is that constipation would be addressed in the first month, sleep in the second, and focus in the third. I'm waiting to see the results.
10
Colic and constipation resolved
1 people found this helpful
The child immediately became calm after taking it. Both constipation and colic have disappeared.
9
Improved sleep
This magnesium is excellent quality, easy to dose, and drink. My mother began taking it, leading to stable blood pressure, alleviation of constipation, improved sleep, and reduced nervousness. Initially, she disliked the taste, but she has grown accustomed to it and now appreciates the sweet aftertaste. It does not cause the heaviness in the stomach often associated with tablets.
0
Experiencing constipation
The product is good quality and has a neutral taste. However, while taking it I felt stronger, but it caused constipation, prompting me to revert to magnesium oxide.
9
Constipation relief
While studying for exams, I was inactive and became constipated. Taking magnesium along with lactic acid bacteria resolved my constipation. However, a meal is necessary for optimal results. The powder turns slightly cloudy when mixed with water, and the taste is somewhat unpleasant. Overall, I found the quality satisfactory.
7.5
Reduced constipation
I purchased magnesium for my child for the first time in powder form. Initially, the taste was unappealing, so I diluted it with sweet tea or juice. She now combines it with another magnesium powder while reducing portions. Since then, her sleep has improved, and she no longer experiences frequent constipation. I administer it after or during meals, 2-3 hours before bedtime.
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
4
Magnesium aids constipation relief
Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units.
We investigated how magnesium hydroxide syrup affects constipation among patients recovering from acute myocardial infarction in an intensive care unit (ICU). Participants were divided into two groups: one received magnesium hydroxide syrup daily, while the other was given flaxseed powder. Our aim was to determine which treatment better supported bowel movements in these patients.
The findings revealed that magnesium hydroxide syrup indeed plays a role in managing constipation. Patients taking this syrup experienced their first bowel movement significantly sooner, averaging just under 25 hours. Although both treatments increased bowel movement frequency and improved stool consistency, the differences between the two groups were not statistically significant. In other words, while magnesium did help prompt quicker bowel movements, it wasn't drastically better than flaxseed powder in terms of the overall outcomes.
Overall, the study highlights magnesium hydroxide syrup as a viable option for easing constipation for patients in recovery, though its effectiveness is comparable to that of flaxseed powder. The time to the first defecation was notably quicker with magnesium, suggesting its potential utility in clinical settings where prompt relief is crucial.
8
Magnesium's role in constipation treatment
Effect of magnesium oxide with probiotics on bowel movements in elderly orthopedic patients with chronic constipation: a retrospective chart review.
We aimed to understand how magnesium, particularly when combined with probiotics, influences bowel movements in elderly orthopedic patients suffering from chronic constipation. A retrospective chart review allowed us to analyze various patient records, focusing specifically on the treatments they received and the outcomes.
Magnesium is often talked about as a potential remedy for constipation because it can help draw water into the intestines, making it easier to pass stools. However, since our study also involved probiotics, which can also impact gut health, it becomes harder to isolate the specific effects of magnesium alone.
After reviewing the data, we observed that the combination of magnesium and probiotics did not show a significant advantage in improving bowel movements for the patients involved. This indicates that while magnesium may play a supportive role, its effectiveness on constipation could vary depending on individual circumstances and may not be as pronounced when combined with other treatments.
Overall, this study serves as a reminder of the complexity of managing constipation, especially in the elderly population, where multiple factors can come into play.
References
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Watanabe N, Itano A, Ando M, Kawahara M. Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study. J Rural Med. 2024;19:192. doi:10.2185/jrm.2023-038
Amjadi Suraki S, Bagheri-Nesami M, Nabati M, Moosazadeh M, Habibi E. Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units. Caspian J Intern Med. 2024;15:234. doi:10.22088/cjim.15.2.234
Nagamine T. Effect of magnesium oxide with probiotics on bowel movements in elderly orthopedic patients with chronic constipation: a retrospective chart review. Biosci Microbiota Food Health. 2024;43:1. doi:10.12938/bmfh.2023-040
Park CW, Lee J, Hong YH, Kim YS, Suh HJ, et al. Coadministration of Lactulose with Probiotics Ameliorates Loperamide-Induced Constipation in Mice. Prev Nutr Food Sci. 2023;28:427. doi:10.3746/pnf.2023.28.4.427
Ishii H, Sawada R, Shiomi M, Shibuya K. A case-control study showing low creatinine clearance and high magnesium intake as risk factors for hypermagnesemia in older individuals. Magnes Res. 2023;36:23. doi:10.1684/mrh.2023.0513
Sasaki H, Hayashi K, Imamura M, Hirota Y, Hosoki H, et al. Combined resistant dextrin and low-dose Mg oxide administration increases short-chain fatty acid and lactic acid production by gut microbiota. J Nutr Biochem. 2023;120:109420. doi:10.1016/j.jnutbio.2023.109420
van der Schoot A, Creedon A, Whelan K, Dimidi E. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Neurogastroenterol Motil. 2023;35:e14613. doi:10.1111/nmo.14613
Suzuki S, Obara T, Ishikawa T, Noda A, Matsuzaki F, et al. No association between major congenital malformations and exposure to Kampo medicines containing rhubarb rhizome: A Japanese database study. Front Pharmacol. 2023;14:1107494. doi:10.3389/fphar.2023.1107494
Kistemaker KRJ, de Graeff A, Crul M, de Klerk G, van de Ven PM, et al. Magnesium hydroxide versus macrogol/electrolytes in the prevention of opioid-induced constipation in incurable cancer patients: study protocol for an open-label, randomized controlled trial (the OMAMA study). BMC Palliat Care. 2023;22:22. doi:10.1186/s12904-023-01143-2
Wu S, Jin T, Ma B, Ji Y, Huang X, et al. Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial. Cancer Med. 2023;12:4343. doi:10.1002/cam4.4922
Maezawa M, Inoue M, Satake R, Wakabayashi W, Oura K, et al. Effect of acid suppressant medications on the laxative action of magnesium preparations in patients with opioid-induced constipation: A pharmacovigilance analysis of the FDA Adverse Event Reporting System. Pharmazie. 2023;78:245. doi:10.1691/ph.2023.3624
Takemura M, Niki K, Miyaguchi S, Ueda M. Naldemedine-laxative combination: retrospective inpatient study. BMJ Support Palliat Care. 2024;13:e816. doi:10.1136/spcare-2022-003685
Worona-Dibner L, Vázquez-Frias R, Valdez-Chávez L, Verdiguel-Oyola M. Efficacy, safety, and acceptability of polyethylene glycol 3350 without electrolytes vs magnesium hydroxide in functional constipation in children from six months to eighteen years of age: A controlled clinical trial. Rev Gastroenterol Mex (Engl Ed). 2023;88:107. doi:10.1016/j.rgmxen.2021.12.005
de Campos GRC, Sandy NS, Lomazi EA, Bellomo-Brandao MA. Management of children with functional constipation referred to tertiary care. J Pediatr (Rio J). 2022;98:289. doi:10.1016/j.jped.2021.06.006
Rao SSC, Brenner DM. Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review. Am J Gastroenterol. 2021;116:1156. doi:10.14309/ajg.0000000000001222
Hassanein SMA, Deifallah SM, Bastawy HA. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial. World J Pediatr. 2021;17:92. doi:10.1007/s12519-020-00401-0
Morishita D, Tomita T, Mori S, Kimura T, Oshima T, et al. Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial. Am J Gastroenterol. 2021;116:152. doi:10.14309/ajg.0000000000000942
Kubota M, Ito K, Tomimoto K, Kanazaki M, Tsukiyama K, et al. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial. Nutrients. 2020;12. doi:10.3390/nu12010225
Ohkubo H, Yoshihara T, Misawa N, Ashikari K, Fuyuki A, et al. Relationship between Stool Form and Quality of Life in Patients with Chronic Constipation: An Internet Questionnaire Survey. Digestion. 2021;102:147. doi:10.1159/000502815
Dupont C, Constant F, Imbert A, Hébert G, Zourabichvili O, et al. Time to treatment response of a magnesium- and sulphate-rich natural mineral water in functional constipation. Nutrition. 2019;65:167. doi:10.1016/j.nut.2019.02.018
Tsuji S, Horiuchi A, Tamaki M, Ichise Y, Kajiyama M, et al. Effectiveness and safety of a new regimen of polyethylene glycol plus ascorbic acid for same-day bowel cleansing in constipated patients. Acta Gastroenterol Belg. 2018;81:485.