' 
![]()
SCIENTIFIC SCORE
Possibly Effective
Based on 33 Researches
7.9
USERS' SCORE
Good
Based on 29 Reviews
8.9
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Total Carbohydrate
<1g
<1%†
Calcium (from calcium magnesium phytate)
131 mg
10%
Phosphorus (from calcium magnesium phytate)
192 mg
15%
Magnesium (from calcium magnesium phytate)
40 mg
10%
IP-6 (inositol hexaphosphate) (from calcium magnesium phytate)
800 mg
**
Inositol
220 mg
**
Maitake Mushroom Extract standardized to 30% pure D-fraction (9 mg)
30 mg
**
Cat's Claw Extract (bark) standardized to 4% alkaloids (0.4 mg)
10 mg
**
Top Medical Research Studies
9
Myo-inositol affects prostate cancer cells
Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line.
Direct investigation of Myo-inositol
We investigated the potential benefits of Myo-inositol, a naturally occurring sugar alcohol, on DU-145 prostate cancer cells. By treating these cancer cells with various doses of Myo-inositol, we determined its half-maximal inhibitory concentration (IC50) using a simple method that measures cell viability.
Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.
Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.
Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.
Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.
Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
Read More
9
Maitake mushroom polysaccharides combat cancer
Polysaccharide with anticancer activity from Grifola frondosa cultured in industrial wastewater of Agaricus bisporus.
Direct cancer treatment focus
We explored the potential of the maitake mushroom (Grifola frondosa) to fight cancer by examining polysaccharides cultivated in industrial wastewater from Agaricus bisporus. Our research involved optimizing various culture conditions like temperature, shaking speed, and the solubility of the wastewater to maximize fungal growth.
Through our studies, we isolated and analyzed several polysaccharides, discovering that one in particular, NIPGF01, showed promising anticancer properties. We observed that NIPGF01 could significantly inhibit the growth of human gastric and liver cancer cells. The apoptosis rates we measured indicated that as we increased concentrations of NIPGF01, more cancer cells underwent programmed cell death—a positive sign in cancer treatment.
Notably, the study also included methods like UV and molecular weight analysis to ensure the purity and composition of the polysaccharides. These investigations confirmed that NIPGF01 contained pure glucose while showcasing structural features important for its activity. Overall, our findings point towards the maitake mushroom as a promising candidate for cancer research, particularly with the polysaccharides demonstrating strong biological effects.
Through our studies, we isolated and analyzed several polysaccharides, discovering that one in particular, NIPGF01, showed promising anticancer properties. We observed that NIPGF01 could significantly inhibit the growth of human gastric and liver cancer cells. The apoptosis rates we measured indicated that as we increased concentrations of NIPGF01, more cancer cells underwent programmed cell death—a positive sign in cancer treatment.
Notably, the study also included methods like UV and molecular weight analysis to ensure the purity and composition of the polysaccharides. These investigations confirmed that NIPGF01 contained pure glucose while showcasing structural features important for its activity. Overall, our findings point towards the maitake mushroom as a promising candidate for cancer research, particularly with the polysaccharides demonstrating strong biological effects.
Read More
9
Maitake enhances anti-cancer immunity
Polysaccharide isolated from eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T cells responses.
Direct study on mushroom benefits
We investigated the potential of a polysaccharide extracted from maitake mushrooms in combatting breast cancer. Our research focused on how this natural compound can alter the immune landscape in tumor-bearing mice, particularly by targeting myeloid-derived suppressor cells (MDSCs), which are notorious for promoting cancer growth.
The treatment with maitake mushroom polysaccharide, referred to as GFI, led to a dramatic reduction of MDSCs in the bloodstream and tumor tissues. Importantly, we observed that GFI specifically decreased the levels of PMN-MDSCs in the spleen, while leaving another type, M-MDSCs, mostly unaffected. This selective action indicates a promising therapeutic strategy for enhancing the immune response.
Moreover, GFI treatment not only reduced the presence of these suppressor cells but also helped restore and activate CD8T cells, key players in fighting tumors. This was evidenced by a remarkable increase in Granzyme B levels coupled with a decrease in TIGIT expression. Ultimately, we demonstrated that the polysaccharide treatment significantly inhibited tumor growth in our models. This study reveals the multifaceted role of maitake mushroom polysaccharides in boosting anti-cancer immune activity, making it a noteworthy candidate for further research in breast cancer therapy.
The treatment with maitake mushroom polysaccharide, referred to as GFI, led to a dramatic reduction of MDSCs in the bloodstream and tumor tissues. Importantly, we observed that GFI specifically decreased the levels of PMN-MDSCs in the spleen, while leaving another type, M-MDSCs, mostly unaffected. This selective action indicates a promising therapeutic strategy for enhancing the immune response.
Moreover, GFI treatment not only reduced the presence of these suppressor cells but also helped restore and activate CD8T cells, key players in fighting tumors. This was evidenced by a remarkable increase in Granzyme B levels coupled with a decrease in TIGIT expression. Ultimately, we demonstrated that the polysaccharide treatment significantly inhibited tumor growth in our models. This study reveals the multifaceted role of maitake mushroom polysaccharides in boosting anti-cancer immune activity, making it a noteworthy candidate for further research in breast cancer therapy.
Read More
Most Useful Reviews
9.5
Remission success
READ THIS—MAX3 HELPS KILL GLIOBLASTOMA BRAIN CANCER. This product has put my Mum in remission from glioblastoma brain cancer! With MAX3, MSM, Frankincense pills, and black seed oil, her MRIs have been clear! This cancer was deemed a death sentence, yet here she is happily wearing her beautiful wigs. I have been advised to make her "eat" this all day. Her immune system is functioning exceptionally well and combating cancer. I firmly believe this product, among others, has kept her healthy and alive. While she is undergoing chemotherapy and radiation treatments, she occasionally feels a bit "run down".
Read More
9.5
Dog survival
We give this to our dog, who had cancer and was advised for hospice by the vet. The foster mum believed she might thrive with this supplement. After six months, she's doing remarkably well—happy and active, showing no signs of the disease returning.
Read More
10
Cancer free
This is an extraordinary product; my sister had Stage 3 ovarian cancer and is now cancer-free after using it. My cousin had a lump in her chest that also disappeared thanks to this product.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 33 Researches
7.9
9.5
Maitake mushroom enhances cancer vaccine
GFPBW1, a β-glucan from Grifola frondosa as vaccine adjuvant: APCs activation and maturation.
Relevant effects but not isolated
We examined the potential of a specific β-glucan, GFPBW1, derived from maitake mushrooms to enhance the effectiveness of cancer vaccines. The study involved the use of OVA-antigen and a B16-OVA tumor model to see how GFPBW1 might improve immune responses.
Our findings indicated that different doses of GFPBW1 significantly boosted the activation and maturation of immune cells known as antigen presenting cells (APCs). By increasing important markers, we observed greater immune responses, which included higher levels of OVA-specific antibody subtypes like IgG1 and IgG3. This suggests that GFPBW1 could effectively work as an adjuvant, facilitating both Th1 (cell-mediated) and Th2 (humoral) immune responses, which are crucial in fighting cancer.
Additionally, we noted that when GFPBW1 was combined with aluminum, commonly used in vaccines, it led to even higher levels of specific antibodies, creating a balanced immune response. Importantly, the mice that received GFPBW1 with the vaccine did not show any harmful side effects.
In tumor models, GFPBW1 demonstrated remarkable potential in suppressing tumors when used in preventive settings and also enhanced the effects of therapeutic vaccines. The research highlighted a significant increase in targeting immune cells directly to the tumor environment, which illustrates the beneficial role GFPBW1 could play in both vaccine development and cancer therapy.
Our findings indicated that different doses of GFPBW1 significantly boosted the activation and maturation of immune cells known as antigen presenting cells (APCs). By increasing important markers, we observed greater immune responses, which included higher levels of OVA-specific antibody subtypes like IgG1 and IgG3. This suggests that GFPBW1 could effectively work as an adjuvant, facilitating both Th1 (cell-mediated) and Th2 (humoral) immune responses, which are crucial in fighting cancer.
Additionally, we noted that when GFPBW1 was combined with aluminum, commonly used in vaccines, it led to even higher levels of specific antibodies, creating a balanced immune response. Importantly, the mice that received GFPBW1 with the vaccine did not show any harmful side effects.
In tumor models, GFPBW1 demonstrated remarkable potential in suppressing tumors when used in preventive settings and also enhanced the effects of therapeutic vaccines. The research highlighted a significant increase in targeting immune cells directly to the tumor environment, which illustrates the beneficial role GFPBW1 could play in both vaccine development and cancer therapy.
Read More
9
Myo-inositol affects prostate cancer cells
Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line.
Direct investigation of Myo-inositol
We investigated the potential benefits of Myo-inositol, a naturally occurring sugar alcohol, on DU-145 prostate cancer cells. By treating these cancer cells with various doses of Myo-inositol, we determined its half-maximal inhibitory concentration (IC50) using a simple method that measures cell viability.
Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.
Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.
Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.
Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.
Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
Read More
9
Maitake mushroom polysaccharides combat cancer
Polysaccharide with anticancer activity from Grifola frondosa cultured in industrial wastewater of Agaricus bisporus.
Direct cancer treatment focus
We explored the potential of the maitake mushroom (Grifola frondosa) to fight cancer by examining polysaccharides cultivated in industrial wastewater from Agaricus bisporus. Our research involved optimizing various culture conditions like temperature, shaking speed, and the solubility of the wastewater to maximize fungal growth.
Through our studies, we isolated and analyzed several polysaccharides, discovering that one in particular, NIPGF01, showed promising anticancer properties. We observed that NIPGF01 could significantly inhibit the growth of human gastric and liver cancer cells. The apoptosis rates we measured indicated that as we increased concentrations of NIPGF01, more cancer cells underwent programmed cell death—a positive sign in cancer treatment.
Notably, the study also included methods like UV and molecular weight analysis to ensure the purity and composition of the polysaccharides. These investigations confirmed that NIPGF01 contained pure glucose while showcasing structural features important for its activity. Overall, our findings point towards the maitake mushroom as a promising candidate for cancer research, particularly with the polysaccharides demonstrating strong biological effects.
Through our studies, we isolated and analyzed several polysaccharides, discovering that one in particular, NIPGF01, showed promising anticancer properties. We observed that NIPGF01 could significantly inhibit the growth of human gastric and liver cancer cells. The apoptosis rates we measured indicated that as we increased concentrations of NIPGF01, more cancer cells underwent programmed cell death—a positive sign in cancer treatment.
Notably, the study also included methods like UV and molecular weight analysis to ensure the purity and composition of the polysaccharides. These investigations confirmed that NIPGF01 contained pure glucose while showcasing structural features important for its activity. Overall, our findings point towards the maitake mushroom as a promising candidate for cancer research, particularly with the polysaccharides demonstrating strong biological effects.
Read More
9
Maitake mushroom boosts cancer therapy
Maitake Beta-Glucan Enhances the Therapeutic Effect of Trastuzumab via Antibody-Dependent Cellular Cytotoxicity and Complement-Dependent Cytotoxicity.
Study demonstrates combination effectiveness
We examined how Maitake β-glucan, specifically the MD-Fraction isolated from the maitake mushroom, could improve treatments for HER2-positive breast cancer when combined with trastuzumab, a common anti-HER2 antibody. Our investigation showed that MD-Fraction does not directly kill HER2-positive cancer cells on its own or even alongside trastuzumab in laboratory settings. However, when we looked at mouse models with HER2-positive tumors, the combination of MD-Fraction and trastuzumab proved to be more effective than trastuzumab alone.
We found that immune cells, like natural killer cells and macrophages from mice treated with MD-Fraction, exhibited enhanced capabilities for attacking cancer cells with trastuzumab. Notably, these immune cells showed increased antibody-dependent cellular cytotoxicity (ADCC), which is one way the immune system can help fight cancer. Additionally, when these cells were present in the body’s natural serum, they were able to enhance complement-dependent cytotoxicity (CDCC), another mechanism of tumor cell destruction.
Overall, our findings illustrate that combining MD-Fraction with trastuzumab enhances the effectiveness of the treatment by bolstering these immune responses. This research highlights an exciting avenue for improving therapies for patients with HER2-positive breast cancer, potentially increasing their chances of successful treatment.
We found that immune cells, like natural killer cells and macrophages from mice treated with MD-Fraction, exhibited enhanced capabilities for attacking cancer cells with trastuzumab. Notably, these immune cells showed increased antibody-dependent cellular cytotoxicity (ADCC), which is one way the immune system can help fight cancer. Additionally, when these cells were present in the body’s natural serum, they were able to enhance complement-dependent cytotoxicity (CDCC), another mechanism of tumor cell destruction.
Overall, our findings illustrate that combining MD-Fraction with trastuzumab enhances the effectiveness of the treatment by bolstering these immune responses. This research highlights an exciting avenue for improving therapies for patients with HER2-positive breast cancer, potentially increasing their chances of successful treatment.
Read More
9
Maitake enhances anti-cancer immunity
Polysaccharide isolated from eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T cells responses.
Direct study on mushroom benefits
We investigated the potential of a polysaccharide extracted from maitake mushrooms in combatting breast cancer. Our research focused on how this natural compound can alter the immune landscape in tumor-bearing mice, particularly by targeting myeloid-derived suppressor cells (MDSCs), which are notorious for promoting cancer growth.
The treatment with maitake mushroom polysaccharide, referred to as GFI, led to a dramatic reduction of MDSCs in the bloodstream and tumor tissues. Importantly, we observed that GFI specifically decreased the levels of PMN-MDSCs in the spleen, while leaving another type, M-MDSCs, mostly unaffected. This selective action indicates a promising therapeutic strategy for enhancing the immune response.
Moreover, GFI treatment not only reduced the presence of these suppressor cells but also helped restore and activate CD8T cells, key players in fighting tumors. This was evidenced by a remarkable increase in Granzyme B levels coupled with a decrease in TIGIT expression. Ultimately, we demonstrated that the polysaccharide treatment significantly inhibited tumor growth in our models. This study reveals the multifaceted role of maitake mushroom polysaccharides in boosting anti-cancer immune activity, making it a noteworthy candidate for further research in breast cancer therapy.
The treatment with maitake mushroom polysaccharide, referred to as GFI, led to a dramatic reduction of MDSCs in the bloodstream and tumor tissues. Importantly, we observed that GFI specifically decreased the levels of PMN-MDSCs in the spleen, while leaving another type, M-MDSCs, mostly unaffected. This selective action indicates a promising therapeutic strategy for enhancing the immune response.
Moreover, GFI treatment not only reduced the presence of these suppressor cells but also helped restore and activate CD8T cells, key players in fighting tumors. This was evidenced by a remarkable increase in Granzyme B levels coupled with a decrease in TIGIT expression. Ultimately, we demonstrated that the polysaccharide treatment significantly inhibited tumor growth in our models. This study reveals the multifaceted role of maitake mushroom polysaccharides in boosting anti-cancer immune activity, making it a noteworthy candidate for further research in breast cancer therapy.
Read More
User Reviews
USERS' SCORE
Good
Based on 29 Reviews
8.9
10
Cancer free
This is an extraordinary product; my sister had Stage 3 ovarian cancer and is now cancer-free after using it. My cousin had a lump in her chest that also disappeared thanks to this product.
9.5
Supports cancer treatment
Since being diagnosed with throat cancer and starting chemotherapy, I've taken Cell Forte MAX3 for a few months. I feel it has helped keep me fighting fit during this challenging time. The quality appears good, and it complements a balanced diet.
9.5
Preventing recurrence
As a cancer survivor, I take this supplement to help prevent recurrence.
9.5
Effective cancer treatment
This is the best cancer fighter available; I feel my body is protected by this.
9.5
Boosts immunity
This product is wonderful in combating cancer and mitigating the effects of chemotherapy by boosting my immunity.
