Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 60 Researches
8
USERS' SCORE
Good
Based on 11 Reviews
8.4
Supplement Facts
Serving Size: 2 Caplets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
1%¹
Dietary Fiber
1 g
4%¹
Selenium (from culture media)
100 mcg
182%
RM-10 Fermented Organic Mushroom BlendMaitake (Grifola frondosa) mycelia*, Shiitake (Lentinula edodes) mycelia*, Reishi (Ganoderma lucidum) mycelia*, Coriolus versicolor mycelia*, Bionectria ochroleuca mycelia, Wolfiporia cocos mycelia*, Hericium erinaceus mycelia*, Formitopsis cajanderi mycelia*, Annulohypoxylon stygium mycelia*, Agaricus blazei mycelia*
1.16 g
+
Cat's Claw (Uncaria tomentosa) Bark
240 mg
+
Top Medical Research Studies
9.5
We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
Read More
8
We explored how selenium, a trace element, can play a role in preventing and treating lung cancer. This review focused on various forms of selenium, including sodium selenite, methylselenic acid, selenomethionine, and selenium nanoparticles.
We observed that these compounds could exert a cytotoxic effect on lung cancer cells, which is crucial for developing new therapies. Additionally, we discussed recent advancements in lung cancer nanomedicine that utilize selenium-based nanoparticles and nanocomposites, assessing their potential to form effective anti-cancer drugs.
Moreover, we studied selenoproteins' roles and the signaling pathways they affect in lung cancer progression or inhibition. Overall, this review provides valuable insights into how selenium and its related compounds might impact lung cancer therapy, while also highlighting the need for further research to realize their full potential in treatment and prevention strategies.
We observed that these compounds could exert a cytotoxic effect on lung cancer cells, which is crucial for developing new therapies. Additionally, we discussed recent advancements in lung cancer nanomedicine that utilize selenium-based nanoparticles and nanocomposites, assessing their potential to form effective anti-cancer drugs.
Moreover, we studied selenoproteins' roles and the signaling pathways they affect in lung cancer progression or inhibition. Overall, this review provides valuable insights into how selenium and its related compounds might impact lung cancer therapy, while also highlighting the need for further research to realize their full potential in treatment and prevention strategies.
Read More
9
We aimed to understand the impact of selenium-enriched Akkermansia muciniphila (Se-AM) on colon cancer, specifically looking at its effectiveness in treating tumors in mice. By enriching the probiotics with inorganic selenium, we prepared Se-AM and evaluated its performance against colon cancer cells using a mouse model.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Read More
Most Useful Reviews
9
Strong immune support
55 people found this helpful
RM-10 is an essential supplement for those with cancer or MS. For stage 3 or 4 breast cancer, one must take 10 to 20 pills three times a day. Having battled bladder cancer myself, I found that an alkaline diet alongside RM-10 was vital in achieving remission. Proper nutrition and supplements saved my life and kept my immune system strong during treatment.
Read More
9
Boosts immune system
29 people found this helpful
Garden of Life Immune System RM-10, 120 Caps. I've been taking 6 pills daily for a month, primarily before lunch. This seems to keep my immune system functioning well, as I haven't caught my wife's cold, despite being surrounded by coughs. Normally, I'd catch a cold quickly, but not this time. I appreciate that these pills were created to help save a grandmother from cancer and proved effective. I would recommend them.
Read More
7.5
Cancer risk reduced
18 people found this helpful
This supplement has been essential for my health over the years, preventing colds and flu. Selenium, a key ingredient, significantly reduces cancer risk according to studies. Those taking selenium saw a marked decrease in various cancers, reinforcing its importance in health management.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 60 Researches
8
- All Researches
9.5
We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
Read More
9.5
We investigated the impact of selenium nanoparticles (SeNPs) on enhancing treatment for advanced non-small-cell lung cancer (NSCLC). Our research revealed that selenium deficiency is linked to immune dysfunction in patients, contributing to cancer progression. In experiments with mice, low selenium led to weakened immunity and faster tumor growth.
Importantly, we found that SeNPs can improve the effectiveness of chemotherapy drugs by promoting the immune response. A clinical trial showed striking results with an 83.3% response rate and 100% disease control with SeNPs in combination with standard treatments. Thus, selenium is shown to significantly support cancer therapy.
Importantly, we found that SeNPs can improve the effectiveness of chemotherapy drugs by promoting the immune response. A clinical trial showed striking results with an 83.3% response rate and 100% disease control with SeNPs in combination with standard treatments. Thus, selenium is shown to significantly support cancer therapy.
Read More
9.5
We examined the potential of a specific β-glucan, GFPBW1, derived from maitake mushrooms to enhance the effectiveness of cancer vaccines. The study involved the use of OVA-antigen and a B16-OVA tumor model to see how GFPBW1 might improve immune responses.
Our findings indicated that different doses of GFPBW1 significantly boosted the activation and maturation of immune cells known as antigen presenting cells (APCs). By increasing important markers, we observed greater immune responses, which included higher levels of OVA-specific antibody subtypes like IgG1 and IgG3. This suggests that GFPBW1 could effectively work as an adjuvant, facilitating both Th1 (cell-mediated) and Th2 (humoral) immune responses, which are crucial in fighting cancer.
Additionally, we noted that when GFPBW1 was combined with aluminum, commonly used in vaccines, it led to even higher levels of specific antibodies, creating a balanced immune response. Importantly, the mice that received GFPBW1 with the vaccine did not show any harmful side effects.
In tumor models, GFPBW1 demonstrated remarkable potential in suppressing tumors when used in preventive settings and also enhanced the effects of therapeutic vaccines. The research highlighted a significant increase in targeting immune cells directly to the tumor environment, which illustrates the beneficial role GFPBW1 could play in both vaccine development and cancer therapy.
Our findings indicated that different doses of GFPBW1 significantly boosted the activation and maturation of immune cells known as antigen presenting cells (APCs). By increasing important markers, we observed greater immune responses, which included higher levels of OVA-specific antibody subtypes like IgG1 and IgG3. This suggests that GFPBW1 could effectively work as an adjuvant, facilitating both Th1 (cell-mediated) and Th2 (humoral) immune responses, which are crucial in fighting cancer.
Additionally, we noted that when GFPBW1 was combined with aluminum, commonly used in vaccines, it led to even higher levels of specific antibodies, creating a balanced immune response. Importantly, the mice that received GFPBW1 with the vaccine did not show any harmful side effects.
In tumor models, GFPBW1 demonstrated remarkable potential in suppressing tumors when used in preventive settings and also enhanced the effects of therapeutic vaccines. The research highlighted a significant increase in targeting immune cells directly to the tumor environment, which illustrates the beneficial role GFPBW1 could play in both vaccine development and cancer therapy.
Read More
9
We aimed to understand the impact of selenium-enriched Akkermansia muciniphila (Se-AM) on colon cancer, specifically looking at its effectiveness in treating tumors in mice. By enriching the probiotics with inorganic selenium, we prepared Se-AM and evaluated its performance against colon cancer cells using a mouse model.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Read More
9
Selenium nanoparticles show cancer potential
We focused on the potential of selenium nanoparticles (SeNPs) derived from the medicinal plant Indigofera aspalathoides in treating cancer, particularly its hepatoprotective capabilities. In our exploration, we utilized an ethanolic extract of the plant to green-synthesize SeNPs and then characterized them using several analytical techniques.
The particle sizes were found to be between 50-80 nm, ensuring they are both stable and effective for biological interactions. We evaluated their antioxidant activity and cytotoxic effects, particularly on breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The SeNPs exhibited impressive antioxidant properties, with a DPPH scavenging rate of 70.32% and hydroxyl radical scavenging at 73.68%.
Notably, we discovered that the SeNPs provided significant protection to liver cells at a concentration of 88 μg/mL, maintaining 100% cell viability. However, we also identified that higher selenium concentrations could lead to cytotoxicity. Our findings highlight selenium nanoparticles as promising candidates for addressing oxidative stress and liver-related disorders while offering potential benefits in cancer treatment.
The particle sizes were found to be between 50-80 nm, ensuring they are both stable and effective for biological interactions. We evaluated their antioxidant activity and cytotoxic effects, particularly on breast cancer (MCF-7) and liver cancer (HepG2) cell lines. The SeNPs exhibited impressive antioxidant properties, with a DPPH scavenging rate of 70.32% and hydroxyl radical scavenging at 73.68%.
Notably, we discovered that the SeNPs provided significant protection to liver cells at a concentration of 88 μg/mL, maintaining 100% cell viability. However, we also identified that higher selenium concentrations could lead to cytotoxicity. Our findings highlight selenium nanoparticles as promising candidates for addressing oxidative stress and liver-related disorders while offering potential benefits in cancer treatment.
Read More
User Reviews
USERS' SCORE
Good
Based on 11 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Strong immune support
55 people found this helpful
RM-10 is an essential supplement for those with cancer or MS. For stage 3 or 4 breast cancer, one must take 10 to 20 pills three times a day. Having battled bladder cancer myself, I found that an alkaline diet alongside RM-10 was vital in achieving remission. Proper nutrition and supplements saved my life and kept my immune system strong during treatment.
Read More
9
Boosts immune system
29 people found this helpful
Garden of Life Immune System RM-10, 120 Caps. I've been taking 6 pills daily for a month, primarily before lunch. This seems to keep my immune system functioning well, as I haven't caught my wife's cold, despite being surrounded by coughs. Normally, I'd catch a cold quickly, but not this time. I appreciate that these pills were created to help save a grandmother from cancer and proved effective. I would recommend them.
Read More
7.5
Cancer risk reduced
18 people found this helpful
This supplement has been essential for my health over the years, preventing colds and flu. Selenium, a key ingredient, significantly reduces cancer risk according to studies. Those taking selenium saw a marked decrease in various cancers, reinforcing its importance in health management.
Read More
9
Chemo support
10 people found this helpful
Makes chemo bearable and more! To cut a long story short, I was diagnosed with cancer and had no energy during my first round of chemotherapy. After taking three of these a day during my second round, I experienced no nausea, regained my energy, and could eat normally. These vitamins boost T Cell presence, which is crucial during cancer treatment. If chemotherapy isn't working as intended, these vitamins could actually help cure cancer.
Read More
9
Life-changing supplement
8 people found this helpful
The best immune system supplement available! This is one of the top formulations from Garden of Life. It’s excellent—deserving of 5 stars! Jordan Rubin created this to aid his grandmother who had cancer, and it consistently helps me when I take the maximum allowed dosage each day. Nothing compares!
Read More
Frequently Asked Questions
9
We aimed to understand the impact of selenium-enriched Akkermansia muciniphila (Se-AM) on colon cancer, specifically looking at its effectiveness in treating tumors in mice. By enriching the probiotics with inorganic selenium, we prepared Se-AM and evaluated its performance against colon cancer cells using a mouse model.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
Our findings revealed that Se-AM was effective in killing colon cancer cells, notably the CT26 cells. The effectiveness seemed to depend on the concentration, indicating that higher doses were better at destroying these cancer cells. In addition to this direct killing effect, we saw that Se-AM played a therapeutic role in mice with established tumors by reducing tumor size and positively altering inflammatory markers in the colon.
Importantly, treatment with Se-AM restored gut microbiota diversity back to levels similar to healthy controls. We observed a notable increase in beneficial bacteria, which suggests that Se-AM not only addresses cancer cells but also promotes a healthier gut environment. Furthermore, we didn't find any adverse effects on vital organs in the mice, highlighting the safety of this treatment.
Overall, our work indicates that Se-enriched Akkermansia muciniphila has promising potential in the fight against colon cancer, providing both direct anti-cancer effects and supporting gut health.
8
Selenium nanoparticles show anti-cancer potential
We investigated how selenium nanoparticles (SeNPs), combined with longan polysaccharides (LP), can work as a potent tool against colon cancer. Our research focused on the preparation and stabilization of these nanoparticles to improve their efficacy. We observed that the LP-SeNPs were small, uniform spheres averaging about 100 nanometers in size, and they remained stable for two weeks. This stability was due to how the polysaccharides interacted with selenium's surface.
When we tested these nanoparticles, we found that they did not harm healthy cells from rat intestines. However, they were effective against human colon cancer cells, specifically HCT-116 and HT-29. Notably, the LP-SeNPs led to growth inhibition and changes in the treated cells' appearance. More importantly, they increased levels of reactive oxygen species and caused significant alterations in mitochondrial function, which are all crucial signs of apoptosis, or programmed cell death—a desirable effect in cancer treatment.
Our findings indicate that LP-SeNPs trigger apoptosis by influencing key proteins involved in regulating this process. These results open up exciting prospects for dietary selenium supplements and health-friendly food ingredients, highlighting the potential of LP-SeNPs in cancer prevention and treatment.
When we tested these nanoparticles, we found that they did not harm healthy cells from rat intestines. However, they were effective against human colon cancer cells, specifically HCT-116 and HT-29. Notably, the LP-SeNPs led to growth inhibition and changes in the treated cells' appearance. More importantly, they increased levels of reactive oxygen species and caused significant alterations in mitochondrial function, which are all crucial signs of apoptosis, or programmed cell death—a desirable effect in cancer treatment.
Our findings indicate that LP-SeNPs trigger apoptosis by influencing key proteins involved in regulating this process. These results open up exciting prospects for dietary selenium supplements and health-friendly food ingredients, highlighting the potential of LP-SeNPs in cancer prevention and treatment.
9.5
We examined how a selenium-containing drug, known as RuSe, targets cancer cells while sparing normal cells. This innovative approach leverages the unique properties of selenium, specifically its electrophilic center, to create oxidative stress within cancer cells. By shuttling electrons from biological electron donors, the drug activates a sequence of events detrimental to cancer survival.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
The results were striking; we found that the rate of electron transfer at the selenium site is significantly higher in cancer cells compared to normal cells—1.81 times greater, to be precise. This selective action leads to a lethal effect, with the drug being 14.98 times more harmful to cancer cells than to their healthy counterparts. We observed that the generation of superoxide anions from this process causes DNA damage and triggers the p53 signaling pathway, which enhances the drug's effectiveness in killing cancer cells.
Our findings offer an exciting new avenue for crafting chemotherapeutic agents that can be both efficient and less toxic. By exploiting the special properties of selenium, we open the door to more intelligent and targeted cancer therapies that could reduce side effects for patients.
References
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- Li X, Rui W, Shu P, Sun Y, Yang J. Efficacy Evaluation of Selenium-enriched Akkermansia muciniphila in the Treatment of Colon Tumor Mice. Probiotics Antimicrob Proteins. 2025. 10.1007/s12602-025-10500-x
- Raman S, Kasirajan S, Chinnapandi B, Karthikeyan K, Pandian A, et al. Luminescent Biogenic Selenium Nanoparticles From Indigofera aspalathoides Vahl ex DC: A Novel Hepatoprotective Strategy for Enhancing Live Health. Luminescence. 2025;40:e70101. 10.1002/bio.70101
- Janakiram NB, Mohammed A, Ravillah D, Choi CI, Zhang Y, et al. [Corrigendum] Chemopreventive effects of PBI‑Se, a selenium‑containing analog of PBIT, on AOM‑induced aberrant crypt foci in F344 rats. Oncol Rep. 2025;53. 10.3892/or.2025.8877
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- Wang M, Xu H, Xiong X, Chang L, Zhang K, et al. Antiproliferative activity of selenium-enriched coumarin derivatives on the SK-N-SH neuroblastoma cell line: Mechanistic insights. Eur J Med Chem. 2025;286:117322. 10.1016/j.ejmech.2025.117322
- Zakharia Y, Reis RJ, Kroll MR, Rataan AO, Manchkanti S, et al. Phase I Clinical Trial of High Doses of Seleno-L-methionine in Combination with Axitinib in Patients with Previously Treated Metastatic Clear Cell Renal Cell Carcinoma. Clin Cancer Res. 2025. 10.1158/1078-0432.CCR-24-3234
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- Ban B, Yang H, Liu Y, Luo Z. Se-methylselenocysteine Inhibits Migration and Glycolysis in Anaplastic Thyroid Carcinoma Cells via the ERK1/2 Signaling Pathway . Ann Clin Lab Sci. 2024;54:810.
- He L, Zhang L, Peng Y, He Z. Selenium in cancer management: exploring the therapeutic potential. Front Oncol. 2024;14:1490740. 10.3389/fonc.2024.1490740
- Rataan AO, Xu Y, Geary SM, Zakharia Y, Kamel ES, et al. Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential. Cancer Treat Res Commun. 2024;42:100864. 10.1016/j.ctarc.2025.100864
- Ashraf R, Khalid Z, Qin QP, Iqbal MA, Taskin-Tok T, et al. Synthesis of N-heterocyclic carbene‑selenium complexes modulating apoptosis and autophagy in cancer cells: Probing the interactions with biomolecules and enzymes. Bioorg Chem. 2025;160:108435. 10.1016/j.bioorg.2025.108435
- Wei K, Yin X, Chen F, Wang X, Ding W, et al. Synthesis, characterization, and bioactivity of selenium nanoparticles stabilized by regenerated chitin nanofibers. Int J Biol Macromol. 2025. 10.1016/j.ijbiomac.2025.142791
- Hosseinzadeh Ranjbar M, Einafshar E, Javid H, Jafari N, Sajjadi SS, et al. Enhancing the anticancer effects of rosmarinic acid in PC3 and LNCaP prostate cancer cells using titanium oxide and selenium-doped graphene oxide nanoparticles. Sci Rep. 2025;15:11568. 10.1038/s41598-025-96707-y
- Doostan M, Rahmani Azar A, Maleki H. Selenium nanoparticles and paclitaxel co-delivery by a PCL based nanofibrous scaffold to enhance melanoma therapy. J Biomater Appl. 2025. 10.1177/08853282251330724
- Çiğ B. Selenium reduces oxaliplatin induced neuropathic pain: focus on TRPV1. Front Pharmacol. 2025;16:1549190. 10.3389/fphar.2025.1549190
- Xie F, Liu N, Liu X, Feng X, Yang Z, et al. Insights into folic acid functionalization of self-assembled octenyl succinic anhydride starch micelles towards targeted delivery of selenium nanoparticles. Int J Biol Macromol. 2025;308:142352. 10.1016/j.ijbiomac.2025.142352
- Fu G, Tong J. Synthesis of Epimedium extract selenium nanoparticles and evaluation their efficacy against lung cancer. Gen Physiol Biophys. 2025;44:123. 10.4149/gpb_2024046
- Yu Y, Xie B, Wang J, Luo W, Yang M, et al. Translational Selenium Nanoparticles Promotes Clinical Non-small-cell Lung Cancer Chemotherapy via Activating Selenoprotein-driven Immune Manipulation. Adv Mater. 2025. 10.1002/adma.202415818
- Wang Y, Du Z, Du H, Zhao J, Duan Y, et al. Associations between dietary intake of zinc and selenium and breast cancer: findings from a NHANES cross-sectional study. Chin Clin Oncol. 2025;14:2. 10.21037/cco-24-83
- Szwiec M, Tomiczek-Szwiec J, Marciniak W, Derkacz R, Huzarski T, et al. The Effect of Blood Selenium Level on the pCR Rate in Breast Cancer Patient Receiving Neoadjuvant Chemotherapy. Cancers (Basel). 2025;17. 10.3390/cancers17050839
- Wen X, Zhou Q, Lin S, Mai H, Zhang L. Selenium-modified hydroxyapatite titanium coating: enhancing osteogenesis and inhibiting cancer in bone invasion by head and neck squamous cell carcinoma. Front Bioeng Biotechnol. 2025;13:1552661. 10.3389/fbioe.2025.1552661
- Jin X, Tong W, Sun L, Lu S, Sun P, et al. Association of composite dietary antioxidant index with high risk of prostate cancer in middle-aged and elderly men: insights from NHANES. Front Immunol. 2025;16:1530174. 10.3389/fimmu.2025.1530174
- Sun K, Ma L, Hou J, Li Y, Jiang H, et al. Physalis peruviana heteropolysaccharide-conjugated selenium nanoparticles: Preparation, characterization, and promising applications in cancer therapy. Int J Biol Macromol. 2025;306:141639. 10.1016/j.ijbiomac.2025.141639
- Pan T, Huang J. Polysaccharide with anticancer activity from Grifola frondosa cultured in industrial wastewater of Agaricus bisporus. Int J Biol Macromol. 2024;283:137489. 10.1016/j.ijbiomac.2024.137489
- Xu Y, Huang C, Xu T, Xiang X, Amakye WK, et al. A Water Polysaccharide-Protein Complex from Grifola frondosa Inhibit the Growth of Subcutaneous but Not Peritoneal Colon Tumor under Fasting Condition. Mol Nutr Food Res. 2024;68:e2400023. 10.1002/mnfr.202400023
- He X, Lu JL, Liao WF, Long YR, Zhang X, et al. GFPBW1, a β-glucan from Grifola frondosa as vaccine adjuvant: APCs activation and maturation. Acta Pharmacol Sin. 2024;45:2394. 10.1038/s41401-024-01330-8
- Masuda Y, Yamashita S, Nakayama Y, Shimizu R, Konishi M. Maitake Beta-Glucan Enhances the Therapeutic Effect of Trastuzumab via Antibody-Dependent Cellular Cytotoxicity and Complement-Dependent Cytotoxicity. Biol Pharm Bull. 2024;47:840. 10.1248/bpb.b23-00802
- Abosharaf HA, Gebreel DT, Allam S, El-Atrash A, Tousson E. Ehrlich ascites carcinoma provokes renal toxicity and DNA injury in mice: Therapeutic impact of chitosan and maitake nanoparticles. Basic Clin Pharmacol Toxicol. 2024;134:472. 10.1111/bcpt.13988
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