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SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.2
USERS' SCORE
Good
Based on 14 Reviews
8.8
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Mood Probiotic BlendLactobacillus acidophilusLactobacillus plantarumLactobacillus helveticus R0052Lactobacillus paracaseiLactobacillus caseiLactobacillus brevisLactobacillus rhamnosusLactobacillus bulgaricusLactobacillus gasseriLactobacillus salivariusTotal Lacto Cultures (45 Billion CFU)Bifidobacterium lactisBifidobacterium longum R0175Bifidobacterium bifidumBifidobacterium breveBifidobacterium infantisBifidobacterium longumTotal Bifido Cultures (5 Billion CFU)
200 mg
+
Total Probiotic Cultures
50 Billion CFU¹
Stress Support BlendOrganic Ashwagandha (root), Blueberry (fruit)
350 mg
+
Organic Prebiotic Fiber BlendOrganic Potato [Resistant Starch] (tuber), Organic Acacia Fiber (A. senegal)
675 mg
+
Top Medical Research Studies
8
DHA shows potential for depression
The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.
Direct assessment of DHA's effects
We conducted a study to find out whether docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could effectively help those dealing with major depressive disorder (MDD). Over the course of 12 weeks, 60 participants were involved in a double-blind, placebo-controlled trial. They were divided into two groups: one received 3.2 grams of DHA daily, while the other group was given an equivalent amount of soybean oil as a placebo.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.
Read More
9
Probiotics reduce anxiety in rats
[Antioxidant and anxiolytic effect of and under conditions of normobaric hypoxia with hypercapnia].
Highly relevant to mental health.
We investigated whether administering Lactobacillus acidophilus could alleviate anxiety and oxidative stress in rats, particularly during challenging conditions like hypoxia.
In our study, rats were divided into groups and given probiotics over 30 days. Those treated with Lactobacillus showed less oxidative damage and anxiety than the untreated hypoxia group.
Overall, we found that Lactobacillus acidophilus contributes to reducing anxiety levels, potentially offering an interesting avenue for mental health treatment.
In our study, rats were divided into groups and given probiotics over 30 days. Those treated with Lactobacillus showed less oxidative damage and anxiety than the untreated hypoxia group.
Overall, we found that Lactobacillus acidophilus contributes to reducing anxiety levels, potentially offering an interesting avenue for mental health treatment.
Read More
7
Probiotics may aid depression treatment
Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial.
Relevance score indicates moderate significance.
We explored how probiotics, particularly Lactobacillus acidophilus, might impact depression in patients diagnosed with major depressive disorder (MDD). In a double-blind, placebo-controlled trial involving 40 participants, we found that after eight weeks of probiotic treatment, symptoms of depression improved along with certain metabolic markers.
However, it's important to note that while there were positive changes, probiotics did not significantly affect glucose levels or lipid profiles. Overall, our findings suggest that probiotics might be a helpful addition to depression treatment strategies.
However, it's important to note that while there were positive changes, probiotics did not significantly affect glucose levels or lipid profiles. Overall, our findings suggest that probiotics might be a helpful addition to depression treatment strategies.
Read More
Most Useful Reviews
8.8
Effective for depression
I am satisfied with these probiotics, which support emotional well-being. They contain strains that help calm feelings, relieve stress, and promote relaxation. I previously took a different brand last winter but found similar strains. This product particularly enhanced my mood, which was crucial given my seasonal depression. I noticed substantial improvement in my feelings, likely due to the probiotic strains used, rather than just an ingredient like Ash, which I consumed separately. Unlike my previous product, this one doesn't compromise mood support. It even contains acacia fibre, beneficial for gut health, and I plan to repurchase.
Read More
9.5
Mood improvement noted
After using these probiotics for 11 days, I can confirm that my mental state has greatly improved. My bouts of depression have lessened significantly, and I feel calmer and more positive about life. I am committed to continuing this probiotic for at least four months, as it has genuinely helped me manage my mood and reduce panic attacks. I am thankful for the improvement I’ve experienced and have even ordered a second box.
Read More
9.5
Relief from episodes
My elderly wife has experienced significant improvement after starting these probiotics. Following a stroke and subsequent dementia, she had distressing episodes. After just a few days of taking two capsules daily, she became episode-free for six weeks. These "magic pills" have calmed her anxieties, making life easier for both of us. I’ve also started taking them due to the positive outcomes we've experienced.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.2
9
Probiotics may enhance mood, sleep
Novel Multi-Strain E3 Probiotic Formulation Improved Mental Health Symptoms and Sleep Quality in Hong Kong Chinese.
High relevance for mental health
We investigated the impact of a novel multi-strain E3 probiotic on mental health, sleep quality, and gut microbiome in 68 participants from Hong Kong. After an 8-week treatment, significant improvements were reported in depressive symptoms, anxiety, and sleep quality. Participants showed decreased scores on standardized surveys, with notable changes in gut microbiome composition linked to these improvements. Our findings highlight the potential benefits of probiotics for those experiencing mood disorders and sleep issues, suggesting that these strategies may effectively enhance mental well-being.
Read More
9
Probiotics reduce anxiety in rats
[Antioxidant and anxiolytic effect of and under conditions of normobaric hypoxia with hypercapnia].
Highly relevant to mental health.
We investigated whether administering Lactobacillus acidophilus could alleviate anxiety and oxidative stress in rats, particularly during challenging conditions like hypoxia.
In our study, rats were divided into groups and given probiotics over 30 days. Those treated with Lactobacillus showed less oxidative damage and anxiety than the untreated hypoxia group.
Overall, we found that Lactobacillus acidophilus contributes to reducing anxiety levels, potentially offering an interesting avenue for mental health treatment.
In our study, rats were divided into groups and given probiotics over 30 days. Those treated with Lactobacillus showed less oxidative damage and anxiety than the untreated hypoxia group.
Overall, we found that Lactobacillus acidophilus contributes to reducing anxiety levels, potentially offering an interesting avenue for mental health treatment.
Read More
9
DHA beneficial for depression
Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults.
Moderate relevance to DHA effects
We explored the intriguing relationship between docosahexaenoic acid (DHA), a type of omega-3 polyunsaturated fatty acid, and its potential effects on depression among middle-aged and elderly adults. Our research pulled from a substantial sample size of over 102,000 residents from the UK Biobank, enabling us to thoroughly investigate how varying levels of PUFAs, particularly DHA, are associated with depressive and anxiety disorders.
The findings revealed that higher plasma levels of DHA were linked to a lower risk of developing depressive disorders compared to those with lower levels. Specifically, we observed a hazard ratio of 0.80 for individuals with the highest DHA levels, indicating a significant protective effect. This trend extended to anxiety disorders as well, suggesting that increasing our intake of omega-3 PUFAs might be a reachable goal for enhancing mental health.
Additionally, we noted that higher levels of DHA were also related to a decrease in adverse psychological symptoms. Encompassing the impact on brain health, we incorporated neuroimaging data from nearly 8,800 participants to investigate white matter microstructures, further supporting the link between omega-3 PUFAs like DHA and overall mental well-being.
The evidence we gathered underscores the importance of considering omega-3 PUFAs, particularly DHA, as a promising nutritional approach for helping to prevent and manage depression in older adults.
The findings revealed that higher plasma levels of DHA were linked to a lower risk of developing depressive disorders compared to those with lower levels. Specifically, we observed a hazard ratio of 0.80 for individuals with the highest DHA levels, indicating a significant protective effect. This trend extended to anxiety disorders as well, suggesting that increasing our intake of omega-3 PUFAs might be a reachable goal for enhancing mental health.
Additionally, we noted that higher levels of DHA were also related to a decrease in adverse psychological symptoms. Encompassing the impact on brain health, we incorporated neuroimaging data from nearly 8,800 participants to investigate white matter microstructures, further supporting the link between omega-3 PUFAs like DHA and overall mental well-being.
The evidence we gathered underscores the importance of considering omega-3 PUFAs, particularly DHA, as a promising nutritional approach for helping to prevent and manage depression in older adults.
Read More
9
Omega-3 helps juvenile depression
Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression.
Validates omega-3's effectiveness in depression
We used a unique model to explore how docosahexaenoic acid, an omega-3 fatty acid, may help alleviate symptoms of depression in young mice. By exposing juvenile mice to alternating ultrasound stress frequencies known to induce depressive-like behaviors, we aimed to mimic conditions of juvenile depression.
Throughout the study, these mice received either a supplement containing both DHA and eicosapentaenoic acid (EPA) or a placebo. The results were quite promising! Mice treated with the omega-3 supplement showed significantly fewer signs of depression and anxiety compared to those that received the placebo. This included a noticeable improvement in behaviors related to pleasure and reduced anxiety.
Additionally, the omega-3 treatment seemed to have a positive effect on hormone levels and inflammatory markers in the brain, indicating that the anti-inflammatory properties of DHA could be part of its effectiveness. Overall, our findings suggest that omega-3 fatty acids might hold potential as a therapeutic option for addressing juvenile depression.
Throughout the study, these mice received either a supplement containing both DHA and eicosapentaenoic acid (EPA) or a placebo. The results were quite promising! Mice treated with the omega-3 supplement showed significantly fewer signs of depression and anxiety compared to those that received the placebo. This included a noticeable improvement in behaviors related to pleasure and reduced anxiety.
Additionally, the omega-3 treatment seemed to have a positive effect on hormone levels and inflammatory markers in the brain, indicating that the anti-inflammatory properties of DHA could be part of its effectiveness. Overall, our findings suggest that omega-3 fatty acids might hold potential as a therapeutic option for addressing juvenile depression.
Read More
9
DHA alleviates epilepsy-related depression
DHA and EPA Alleviate Epileptic Depression in PTZ-Treated Young Mice Model by Inhibiting Neuroinflammation through Regulating Microglial M2 Polarization and Improving Mitochondrial Metabolism.
Focus on DHA's isolated effects
We explored the impact of docosahexaenoic acid (DHA) on depressive symptoms associated with epilepsy in a young mouse model. Through our investigation, we fed mice a diet enriched with DHA and administered pentylenetetrazole (PTZ) to induce epilepsy. Notably, our findings indicated that both DHA and eicosapentaenoic acid (EPA) significantly reduced depressive symptoms in this model, with EPA showing even greater effectiveness.
Analyzing the underlying mechanisms revealed that DHA and EPA helped repair neuronal damage and improve myelin structure in the hippocampus—the brain region vital for mood regulation. Furthermore, they tackled neuroinflammation by encouraging the polarizing of microglial cells toward a protective state and suppressing harmful inflammatory responses.
Additionally, we observed that both fatty acids decreased oxidative stress and improved mitochondrial function, which are crucial aspects of brain health. These results suggest that integrating DHA (and EPA) into dietary interventions could offer a promising strategy to alleviate depression in children with epilepsy, providing a potential pathway to enhance their quality of life.
Analyzing the underlying mechanisms revealed that DHA and EPA helped repair neuronal damage and improve myelin structure in the hippocampus—the brain region vital for mood regulation. Furthermore, they tackled neuroinflammation by encouraging the polarizing of microglial cells toward a protective state and suppressing harmful inflammatory responses.
Additionally, we observed that both fatty acids decreased oxidative stress and improved mitochondrial function, which are crucial aspects of brain health. These results suggest that integrating DHA (and EPA) into dietary interventions could offer a promising strategy to alleviate depression in children with epilepsy, providing a potential pathway to enhance their quality of life.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.8
9.5
Mood improvement noted
After using these probiotics for 11 days, I can confirm that my mental state has greatly improved. My bouts of depression have lessened significantly, and I feel calmer and more positive about life. I am committed to continuing this probiotic for at least four months, as it has genuinely helped me manage my mood and reduce panic attacks. I am thankful for the improvement I’ve experienced and have even ordered a second box.
Read More
9.5
Stable mood achieved
These probiotics have become essential for maintaining my mood stability and calmness. Having switched from prescription antidepressants, I relied on this combination supplement, which has effectively helped with my anxiety and depression. I’ve noticed a significant difference after just two weeks of use, enabling me to handle daily challenges better. Though the pills are a bit large, they are easy to take, and I plan to continue using them as they have made a noticeable difference in my life.
Read More
9.5
Relief from episodes
My elderly wife has experienced significant improvement after starting these probiotics. Following a stroke and subsequent dementia, she had distressing episodes. After just a few days of taking two capsules daily, she became episode-free for six weeks. These "magic pills" have calmed her anxieties, making life easier for both of us. I’ve also started taking them due to the positive outcomes we've experienced.
Read More
9.5
Dual benefits confirmed
These probiotics effectively manage both depression and digestion, significantly enhancing my mood while aiding in digestive health. They are a valuable part of my daily regimen.
9.5
Positive change observed
I ordered this for a friend struggling with depression, and she reports feeling better and experiencing improved mood with consistent use of the probiotics. She has requested me to order more, indicating effective results.
