Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.2
USERS' SCORE
Good
Based on 14 Reviews
8.3
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Mood Probiotic BlendLactobacillus acidophilusLactobacillus plantarumLactobacillus helveticus R0052Lactobacillus paracaseiLactobacillus caseiLactobacillus brevisLactobacillus rhamnosusLactobacillus bulgaricusLactobacillus gasseriLactobacillus salivariusTotal Lacto Cultures (45 Billion CFU)Bifidobacterium lactisBifidobacterium longum R0175Bifidobacterium bifidumBifidobacterium breveBifidobacterium infantisBifidobacterium longumTotal Bifido Cultures (5 Billion CFU)
200 mg
+
Total Probiotic Cultures
50 Billion CFU¹
Stress Support BlendOrganic Ashwagandha (root), Blueberry (fruit)
350 mg
+
Organic Prebiotic Fiber BlendOrganic Potato [Resistant Starch] (tuber), Organic Acacia Fiber (A. senegal)
675 mg
+
Top Medical Research Studies
8
We conducted a study to find out whether docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could effectively help those dealing with major depressive disorder (MDD). Over the course of 12 weeks, 60 participants were involved in a double-blind, placebo-controlled trial. They were divided into two groups: one received 3.2 grams of DHA daily, while the other group was given an equivalent amount of soybean oil as a placebo.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.
Read More
9
We investigated whether administering Lactobacillus acidophilus could alleviate anxiety and oxidative stress in rats, particularly during challenging conditions like hypoxia.
In our study, rats were divided into groups and given probiotics over 30 days. Those treated with Lactobacillus showed less oxidative damage and anxiety than the untreated hypoxia group.
Overall, we found that Lactobacillus acidophilus contributes to reducing anxiety levels, potentially offering an interesting avenue for mental health treatment.
In our study, rats were divided into groups and given probiotics over 30 days. Those treated with Lactobacillus showed less oxidative damage and anxiety than the untreated hypoxia group.
Overall, we found that Lactobacillus acidophilus contributes to reducing anxiety levels, potentially offering an interesting avenue for mental health treatment.
Read More
7
Probiotics may aid depression treatment
We explored how probiotics, particularly Lactobacillus acidophilus, might impact depression in patients diagnosed with major depressive disorder (MDD). In a double-blind, placebo-controlled trial involving 40 participants, we found that after eight weeks of probiotic treatment, symptoms of depression improved along with certain metabolic markers.
However, it's important to note that while there were positive changes, probiotics did not significantly affect glucose levels or lipid profiles. Overall, our findings suggest that probiotics might be a helpful addition to depression treatment strategies.
However, it's important to note that while there were positive changes, probiotics did not significantly affect glucose levels or lipid profiles. Overall, our findings suggest that probiotics might be a helpful addition to depression treatment strategies.
Read More
Most Useful Reviews
7.5
Effective for depression
23 people found this helpful
I am satisfied with these probiotics, which support emotional well-being. They contain strains that help calm feelings, relieve stress, and promote relaxation. I previously took a different brand last winter but found similar strains. This product particularly enhanced my mood, which was crucial given my seasonal depression. I noticed substantial improvement in my feelings, likely due to the probiotic strains used, rather than just an ingredient like Ash, which I consumed separately. Unlike my previous product, this one doesn't compromise mood support. It even contains acacia fibre, beneficial for gut health, and I plan to repurchase.
Read More
9
Mood improvement noted
21 people found this helpful
After using these probiotics for 11 days, I can confirm that my mental state has greatly improved. My bouts of depression have lessened significantly, and I feel calmer and more positive about life. I am committed to continuing this probiotic for at least four months, as it has genuinely helped me manage my mood and reduce panic attacks. I am thankful for the improvement I’ve experienced and have even ordered a second box.
Read More
9
Relief from episodes
6 people found this helpful
My elderly wife has experienced significant improvement after starting these probiotics. Following a stroke and subsequent dementia, she had distressing episodes. After just a few days of taking two capsules daily, she became episode-free for six weeks. These "magic pills" have calmed her anxieties, making life easier for both of us. I’ve also started taking them due to the positive outcomes we've experienced.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.2
- All Researches
9
We investigated the impact of a novel multi-strain E3 probiotic on mental health, sleep quality, and gut microbiome in 68 participants from Hong Kong. After an 8-week treatment, significant improvements were reported in depressive symptoms, anxiety, and sleep quality. Participants showed decreased scores on standardized surveys, with notable changes in gut microbiome composition linked to these improvements. Our findings highlight the potential benefits of probiotics for those experiencing mood disorders and sleep issues, suggesting that these strategies may effectively enhance mental well-being.
Read More
9
We investigated whether administering Lactobacillus acidophilus could alleviate anxiety and oxidative stress in rats, particularly during challenging conditions like hypoxia.
In our study, rats were divided into groups and given probiotics over 30 days. Those treated with Lactobacillus showed less oxidative damage and anxiety than the untreated hypoxia group.
Overall, we found that Lactobacillus acidophilus contributes to reducing anxiety levels, potentially offering an interesting avenue for mental health treatment.
In our study, rats were divided into groups and given probiotics over 30 days. Those treated with Lactobacillus showed less oxidative damage and anxiety than the untreated hypoxia group.
Overall, we found that Lactobacillus acidophilus contributes to reducing anxiety levels, potentially offering an interesting avenue for mental health treatment.
Read More
9
We explored the intriguing relationship between docosahexaenoic acid (DHA), a type of omega-3 polyunsaturated fatty acid, and its potential effects on depression among middle-aged and elderly adults. Our research pulled from a substantial sample size of over 102,000 residents from the UK Biobank, enabling us to thoroughly investigate how varying levels of PUFAs, particularly DHA, are associated with depressive and anxiety disorders.
The findings revealed that higher plasma levels of DHA were linked to a lower risk of developing depressive disorders compared to those with lower levels. Specifically, we observed a hazard ratio of 0.80 for individuals with the highest DHA levels, indicating a significant protective effect. This trend extended to anxiety disorders as well, suggesting that increasing our intake of omega-3 PUFAs might be a reachable goal for enhancing mental health.
Additionally, we noted that higher levels of DHA were also related to a decrease in adverse psychological symptoms. Encompassing the impact on brain health, we incorporated neuroimaging data from nearly 8,800 participants to investigate white matter microstructures, further supporting the link between omega-3 PUFAs like DHA and overall mental well-being.
The evidence we gathered underscores the importance of considering omega-3 PUFAs, particularly DHA, as a promising nutritional approach for helping to prevent and manage depression in older adults.
The findings revealed that higher plasma levels of DHA were linked to a lower risk of developing depressive disorders compared to those with lower levels. Specifically, we observed a hazard ratio of 0.80 for individuals with the highest DHA levels, indicating a significant protective effect. This trend extended to anxiety disorders as well, suggesting that increasing our intake of omega-3 PUFAs might be a reachable goal for enhancing mental health.
Additionally, we noted that higher levels of DHA were also related to a decrease in adverse psychological symptoms. Encompassing the impact on brain health, we incorporated neuroimaging data from nearly 8,800 participants to investigate white matter microstructures, further supporting the link between omega-3 PUFAs like DHA and overall mental well-being.
The evidence we gathered underscores the importance of considering omega-3 PUFAs, particularly DHA, as a promising nutritional approach for helping to prevent and manage depression in older adults.
Read More
9
We used a unique model to explore how docosahexaenoic acid, an omega-3 fatty acid, may help alleviate symptoms of depression in young mice. By exposing juvenile mice to alternating ultrasound stress frequencies known to induce depressive-like behaviors, we aimed to mimic conditions of juvenile depression.
Throughout the study, these mice received either a supplement containing both DHA and eicosapentaenoic acid (EPA) or a placebo. The results were quite promising! Mice treated with the omega-3 supplement showed significantly fewer signs of depression and anxiety compared to those that received the placebo. This included a noticeable improvement in behaviors related to pleasure and reduced anxiety.
Additionally, the omega-3 treatment seemed to have a positive effect on hormone levels and inflammatory markers in the brain, indicating that the anti-inflammatory properties of DHA could be part of its effectiveness. Overall, our findings suggest that omega-3 fatty acids might hold potential as a therapeutic option for addressing juvenile depression.
Throughout the study, these mice received either a supplement containing both DHA and eicosapentaenoic acid (EPA) or a placebo. The results were quite promising! Mice treated with the omega-3 supplement showed significantly fewer signs of depression and anxiety compared to those that received the placebo. This included a noticeable improvement in behaviors related to pleasure and reduced anxiety.
Additionally, the omega-3 treatment seemed to have a positive effect on hormone levels and inflammatory markers in the brain, indicating that the anti-inflammatory properties of DHA could be part of its effectiveness. Overall, our findings suggest that omega-3 fatty acids might hold potential as a therapeutic option for addressing juvenile depression.
Read More
9
DHA alleviates epilepsy-related depression
We explored the impact of docosahexaenoic acid (DHA) on depressive symptoms associated with epilepsy in a young mouse model. Through our investigation, we fed mice a diet enriched with DHA and administered pentylenetetrazole (PTZ) to induce epilepsy. Notably, our findings indicated that both DHA and eicosapentaenoic acid (EPA) significantly reduced depressive symptoms in this model, with EPA showing even greater effectiveness.
Analyzing the underlying mechanisms revealed that DHA and EPA helped repair neuronal damage and improve myelin structure in the hippocampus—the brain region vital for mood regulation. Furthermore, they tackled neuroinflammation by encouraging the polarizing of microglial cells toward a protective state and suppressing harmful inflammatory responses.
Additionally, we observed that both fatty acids decreased oxidative stress and improved mitochondrial function, which are crucial aspects of brain health. These results suggest that integrating DHA (and EPA) into dietary interventions could offer a promising strategy to alleviate depression in children with epilepsy, providing a potential pathway to enhance their quality of life.
Analyzing the underlying mechanisms revealed that DHA and EPA helped repair neuronal damage and improve myelin structure in the hippocampus—the brain region vital for mood regulation. Furthermore, they tackled neuroinflammation by encouraging the polarizing of microglial cells toward a protective state and suppressing harmful inflammatory responses.
Additionally, we observed that both fatty acids decreased oxidative stress and improved mitochondrial function, which are crucial aspects of brain health. These results suggest that integrating DHA (and EPA) into dietary interventions could offer a promising strategy to alleviate depression in children with epilepsy, providing a potential pathway to enhance their quality of life.
Read More
User Reviews
USERS' SCORE
Good
Based on 14 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Effective for depression
23 people found this helpful
I am satisfied with these probiotics, which support emotional well-being. They contain strains that help calm feelings, relieve stress, and promote relaxation. I previously took a different brand last winter but found similar strains. This product particularly enhanced my mood, which was crucial given my seasonal depression. I noticed substantial improvement in my feelings, likely due to the probiotic strains used, rather than just an ingredient like Ash, which I consumed separately. Unlike my previous product, this one doesn't compromise mood support. It even contains acacia fibre, beneficial for gut health, and I plan to repurchase.
Read More
9
Mood improvement noted
21 people found this helpful
After using these probiotics for 11 days, I can confirm that my mental state has greatly improved. My bouts of depression have lessened significantly, and I feel calmer and more positive about life. I am committed to continuing this probiotic for at least four months, as it has genuinely helped me manage my mood and reduce panic attacks. I am thankful for the improvement I’ve experienced and have even ordered a second box.
Read More
9
Relief from episodes
6 people found this helpful
My elderly wife has experienced significant improvement after starting these probiotics. Following a stroke and subsequent dementia, she had distressing episodes. After just a few days of taking two capsules daily, she became episode-free for six weeks. These "magic pills" have calmed her anxieties, making life easier for both of us. I’ve also started taking them due to the positive outcomes we've experienced.
Read More
7.5
Moods improved quickly
3 people found this helpful
After purchasing these probiotics to alleviate anxiety and depression, I've noticed a positive change in my mood after just a short period. They were recommended by my nutritionist, which adds assurance to their efficacy. I’m inclined to repurchase when needed in the future.
Read More
9
Dual benefits confirmed
1 people found this helpful
These probiotics effectively manage both depression and digestion, significantly enhancing my mood while aiding in digestive health. They are a valuable part of my daily regimen.
Read More
Frequently Asked Questions
9
Mood improvement noted
21 people found this helpful
After using these probiotics for 11 days, I can confirm that my mental state has greatly improved. My bouts of depression have lessened significantly, and I feel calmer and more positive about life. I am committed to continuing this probiotic for at least four months, as it has genuinely helped me manage my mood and reduce panic attacks. I am thankful for the improvement I’ve experienced and have even ordered a second box.
9
Stable mood achieved
5 people found this helpful
These probiotics have become essential for maintaining my mood stability and calmness. Having switched from prescription antidepressants, I relied on this combination supplement, which has effectively helped with my anxiety and depression. I’ve noticed a significant difference after just two weeks of use, enabling me to handle daily challenges better. Though the pills are a bit large, they are easy to take, and I plan to continue using them as they have made a noticeable difference in my life.
7.5
Effective for depression
23 people found this helpful
I am satisfied with these probiotics, which support emotional well-being. They contain strains that help calm feelings, relieve stress, and promote relaxation. I previously took a different brand last winter but found similar strains. This product particularly enhanced my mood, which was crucial given my seasonal depression. I noticed substantial improvement in my feelings, likely due to the probiotic strains used, rather than just an ingredient like Ash, which I consumed separately. Unlike my previous product, this one doesn't compromise mood support. It even contains acacia fibre, beneficial for gut health, and I plan to repurchase.
9
Relief from episodes
6 people found this helpful
My elderly wife has experienced significant improvement after starting these probiotics. Following a stroke and subsequent dementia, she had distressing episodes. After just a few days of taking two capsules daily, she became episode-free for six weeks. These "magic pills" have calmed her anxieties, making life easier for both of us. I’ve also started taking them due to the positive outcomes we've experienced.
7.5
Moods improved quickly
3 people found this helpful
After purchasing these probiotics to alleviate anxiety and depression, I've noticed a positive change in my mood after just a short period. They were recommended by my nutritionist, which adds assurance to their efficacy. I’m inclined to repurchase when needed in the future.
7.5
Enhanced outlook achieved
1 people found this helpful
I got these probiotics for my father during the COVID lockdown due to his mild depression. They have dramatically improved his mood and attitude, making him much more relaxed and positive. Part of a comprehensive health plan from his naturopath, these probiotics are definitely making a significant difference.
7.5
Stress reduction
1 people found this helpful
Amazing! This product is a wonderfully prepared formula featuring unique elements from this company. It is advantageous for gut health, alleviating stress and gas, boosting serotonin levels, and combating stress and depression. The only downside is its steep price.
7.5
Supports emotional well-being
15 people found this helpful
This probiotic composition is excellent! It includes several strains that have shown to reduce depression and anxiety. Lactobacillus helveticus has proven effective in maintaining a positive mood. The extensive variety of strains and high CFU count provide broad benefits, including improved emotional stability and immune support. I am very pleased with the positive effect it has had on my overall well-being.
8
Probiotic yogurt alleviates depression
We explored the effects of fortified yogurt on women with polycystic ovary syndrome (PCOS) over an 8-week period. In this randomized, double-blind study, one group enjoyed yogurt enriched with probiotics, vitamin E, and vitamin D, while the other had a standard yogurt placebo.
Participants in the yogurt group showed significant improvement in depression levels compared to the placebo group, though no gains were noted in sleep quality. This suggests that incorporating probiotics in dietary interventions may help manage depression in PCOS patients, serving as an alternative for those hesitant to use traditional antidepressants. However, we recognize the need for further research to solidify these findings.
Participants in the yogurt group showed significant improvement in depression levels compared to the placebo group, though no gains were noted in sleep quality. This suggests that incorporating probiotics in dietary interventions may help manage depression in PCOS patients, serving as an alternative for those hesitant to use traditional antidepressants. However, we recognize the need for further research to solidify these findings.
5
We examined the effects of caloric restriction combined with probiotic supplementation on depression symptoms in adult men with obesity. In our randomized, double-blind study over 12 weeks, participants adhered to a specific diet while receiving either probiotics or a placebo.
While we observed improvements in anxiety and depressive symptoms in those taking probiotics, there were no significant differences between the two groups overall. This suggests that while probiotics may offer some benefits, more research is needed to fully understand their impact on mental health.
While we observed improvements in anxiety and depressive symptoms in those taking probiotics, there were no significant differences between the two groups overall. This suggests that while probiotics may offer some benefits, more research is needed to fully understand their impact on mental health.
5
We examined the effects of probiotics, specifically Lactobacillus and Bifidobacterium strains, on symptoms of depression and anxiety through a comprehensive meta-analysis.
Although our findings suggested that probiotics may lead to a notable reduction in depressive symptoms as measured by the Beck Depression Inventory, the overall impact was mixed. We found no significant results on other well-established scales like HAMD, DASS, and MADRS.
This variability highlights the complexity of these mental health conditions and suggests that further research is essential to fully understand how probiotics can influence mood.
Although our findings suggested that probiotics may lead to a notable reduction in depressive symptoms as measured by the Beck Depression Inventory, the overall impact was mixed. We found no significant results on other well-established scales like HAMD, DASS, and MADRS.
This variability highlights the complexity of these mental health conditions and suggests that further research is essential to fully understand how probiotics can influence mood.
8
Lactobacillus shows limited anti-depressant effects
We examined the effects of a cultured milk drink containing Lactobacillus acidophilus on depression in individuals with irritable bowel syndrome (IBS). Our study involved 110 IBS participants, some experiencing subthreshold depression, who consumed the drink daily for 12 weeks.
While we found significant reductions in depression scores and improvements in quality of life across groups, only the probiotics showed notable increases in serotonin levels. This suggests that while Lactobacillus might provide some benefits, it may not be a singular solution for depression in IBS.
While we found significant reductions in depression scores and improvements in quality of life across groups, only the probiotics showed notable increases in serotonin levels. This suggests that while Lactobacillus might provide some benefits, it may not be a singular solution for depression in IBS.
References
- Askarpour M, Hejazi N, Jahromi BN, Eskandari MH, Famouri M, et al. Effects of a Novel Fortified Dairy Product on the Psychological Status and Sleep Quality of Patients with Polycystic Ovary Syndrome: A Double-Blind Randomized Controlled Trial. Prev Nutr Food Sci. 2025;30:37. doi:10.3746/pnf.2025.30.1.37
- Marques CG, Dos Santos Quaresma MVL, França Ferracini CB, Alves Carrilho FB, Nakamoto FP, et al. Effect of caloric restriction with probiotic supplementation on body composition, quality of life, and psychobiological factors of obese men: A randomized, double-blinded placebo-controlled clinical trial. Clin Nutr. 2025;45:234. doi:10.1016/j.clnu.2024.12.031
- Rahmannia M, Poudineh M, Mirzaei R, Aalipour MA, Shahidi Bonjar AH, et al. Strain-specific effects of probiotics on depression and anxiety: a meta-analysis. Gut Pathog. 2024;16:46. doi:10.1186/s13099-024-00634-8
- Sarkawi M, Raja Ali RA, Abdul Wahab N, Abdul Rathi ND, Mokhtar NM. A randomized, double-blinded, placebo-controlled clinical trial on Lactobacillus-containing cultured milk drink as adjuvant therapy for depression in irritable bowel syndrome. Sci Rep. 2024;14:9478. doi:10.1038/s41598-024-60029-2
- Hashemi-Mohammadabad N, Taghavi SA, Lambert N, Moshtaghi R, Bazarganipour F, et al. Adjuvant administration of probiotic effects on sexual function in depressant women undergoing SSRIs treatment: a double-blinded randomized controlled trial. BMC Psychiatry. 2024;24:44. doi:10.1186/s12888-023-05429-w
- Chan HHY, Siu PLK, Choy CT, Chan UK, Zhou J, et al. Novel Multi-Strain E3 Probiotic Formulation Improved Mental Health Symptoms and Sleep Quality in Hong Kong Chinese. Nutrients. 2023;15. doi:10.3390/nu15245037
- Tsai WH, Yeh WL, Chou CH, Wu CL, Lai CH, et al. Suppressive Effects of on Depression through Regulating the Gut Microbiota and Metabolites in C57BL/6J Mice Induced by Ampicillin. Biomedicines. 2023;11. doi:10.3390/biomedicines11041068
- Haghighat N, Mohammadshahi M, Shayanpour S, Haghighizadeh MH, Rahmdel S, et al. The Effect of Synbiotic and Probiotic Supplementation on Mental Health Parameters in Patients Undergoing Hemodialysis: A Double-blind, Randomized, Placebo-controlled Trial. Indian J Nephrol. 2021;31:149. doi:10.4103/ijn.IJN_341_19
- Kozin SV, Kravtsov AA, Kravchenko SV, Ivashchenko LI. [Antioxidant and anxiolytic effect of and under conditions of normobaric hypoxia with hypercapnia]. Vopr Pitan. 2021;90:63. doi:10.33029/0042-8833-2021-90-2-63-72
- Gu F, Wu Y, Liu Y, Dou M, Jiang Y, et al. Lactobacillus casei improves depression-like behavior in chronic unpredictable mild stress-induced rats by the BDNF-TrkB signal pathway and the intestinal microbiota. Food Funct. 2020;11:6148. doi:10.1039/d0fo00373e
- Hadi A, Sepandi M, Marx W, Moradi S, Parastouei K. Clinical and psychological responses to synbiotic supplementation in obese or overweight adults: A randomized clinical trial. Complement Ther Med. 2019;47:102216. doi:10.1016/j.ctim.2019.102216
- Haghighat N, Rajabi S, Mohammadshahi M. Effect of synbiotic and probiotic supplementation on serum brain-derived neurotrophic factor level, depression and anxiety symptoms in hemodialysis patients: a randomized, double-blinded, clinical trial. Nutr Neurosci. 2021;24:490. doi:10.1080/1028415X.2019.1646975
- Akkasheh G, Kashani-Poor Z, Tajabadi-Ebrahimi M, Jafari P, Akbari H, et al. Clinical and metabolic response to probiotic administration in patients with major depressive disorder: A randomized, double-blind, placebo-controlled trial. Nutrition. 2016;32:315. doi:10.1016/j.nut.2015.09.003
- Steenbergen L, Sellaro R, van Hemert S, Bosch JA, Colzato LS. A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood. Brain Behav Immun. 2015;48:258. doi:10.1016/j.bbi.2015.04.003
- Feher J, Pinter E, Kovács I, Helyes Z, Kemény A, et al. Irritable eye syndrome: neuroimmune mechanisms and benefits of selected nutrients. Ocul Surf. 2014;12:134. doi:10.1016/j.jtos.2013.09.002
- Kong L, Zhang Q, Wang H, Xu Y, Xu C, et al. Exploration of the optimized portrait of omega-3 polyunsaturated fatty acids in treating depression: A meta-analysis of randomized-controlled trials. J Affect Disord. 2025. doi:10.1016/j.jad.2025.03.006
- Faulkner P, Gibson EL, Dyall SC. Long-chain omega-3 polyunsaturated fatty acids are associated with brain connectivity and mood in young adults with subthreshold depression: A preliminary study. Prostaglandins Leukot Essent Fatty Acids. 2025;204:102664. doi:10.1016/j.plefa.2025.102664
- Huang S, Guo J, Jiang R, Ma K, Lin F, et al. Four-way decomposition of the effects of nutrient supplement and physical exercise on depression among older Chinese: a nationwide cross-sectional analysis. BMC Public Health. 2024;24:3469. doi:10.1186/s12889-024-20995-8
- Li Y, Hua L, Ran Q, Gu J, Bao Y, et al. Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults. Nutrients. 2024;16. doi:10.3390/nu16234065
- Wu SK, Yang KJ, Liu WC, Malau IA, Zailani H, et al. The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Nutrients. 2024;16. doi:10.3390/nu16213688
- Chen L, Yang Y, Zhang N, Che H, Wang Z, et al. DHA and EPA alleviate depressive-like behaviors in chronic sleep-deprived mice: Involvement of iron metabolism, oligodendrocyte-lipids peroxidation and the LCN2-NLRP3 signaling axis. Free Radic Biol Med. 2024;225:654. doi:10.1016/j.freeradbiomed.2024.10.298
- Cheng YC, Chen WY, Lin C, Lee SH, Chiu CC, et al. The N-3 polyunsaturated fatty acids supplementation to prevent depression recurrence in patients with late-life depression: A 52-week double-blind, placebo-controlled trial. J Affect Disord. 2025;369:8. doi:10.1016/j.jad.2024.09.129
- Serefko A, Jach ME, Pietraszuk M, Świąder M, Świąder K, et al. Omega-3 Polyunsaturated Fatty Acids in Depression. Int J Mol Sci. 2024;25. doi:10.3390/ijms25168675
- Strekalova T, Radford-Smith D, Dunstan IK, Gorlova A, Svirin E, et al. Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression. Neurobiol Stress. 2024;31:100646. doi:10.1016/j.ynstr.2024.100646
- Carnegie R, Borges MC, Jones HJ, Zheng J, Haycock P, et al. Omega-3 fatty acids and major depression: a Mendelian randomization study. Transl Psychiatry. 2024;14:222. doi:10.1038/s41398-024-02932-w
- Wang M, Yan X, Li Y, Li Q, Xu Y, et al. Association between plasma polyunsaturated fatty acids and depressive among US adults. Front Nutr. 2024;11:1342304. doi:10.3389/fnut.2024.1342304
- Chang YY, Ting B, Chen DT, Hsu WT, Lin SC, et al. Omega-3 Fatty Acids for Depression in the Elderly and Patients with Dementia: A Systematic Review and Meta-Analysis. Healthcare (Basel). 2024;12. doi:10.3390/healthcare12050536
- Suneson K, Söderberg Veibäck G, Lindahl J, Tjernberg J, Ståhl D, et al. Omega-3 fatty acids for inflamed depression - A match/mismatch study. Brain Behav Immun. 2024;118:192. doi:10.1016/j.bbi.2024.02.029
- Xue Y, Wang L, Liu T, Zhao T, Xie K, et al. Omega-3 polyunsaturated fatty acids supplementation improves memory in first-diagnosed, drug-naïve patients with depression: Secondary analysis of data from a randomized controlled trial. J Affect Disord. 2024;350:403. doi:10.1016/j.jad.2024.01.149
- Yang Y, Chen L, Zhang N, Zhao Y, Che H, et al. DHA and EPA Alleviate Epileptic Depression in PTZ-Treated Young Mice Model by Inhibiting Neuroinflammation through Regulating Microglial M2 Polarization and Improving Mitochondrial Metabolism. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12122079
