Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.5
USERS' SCORE
Good
Based on 12 Reviews
8.6
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Proprietary Probiotic BlendLacticaseibacillus rhamnosus R0011Lactobacillus helvetius R0052Pediococcus acidilactici R1001Lacticaseibacillus casei R0215Bifidobacterium longum BB536Lactiplantibacillus plantarum R1012Bifidobacterium breve R0070Lactococcus lactis subsp. lactis R1058
131 mg (10 Billion CFU)
†
Top Medical Research Studies
9.5
Microencapsulated LM-20 effective in colitis
We investigated the effects of microencapsulated LM-20, a probiotic, on ulcerative colitis in a lab model. Using advanced microencapsulation techniques, we ensured strong survival rates of this probiotic in harsh gastrointestinal conditions.
Our results were promising—mice receiving LM-20 showed an impressive 83.3% reduction in disease activity. They also had lower levels of harmful inflammatory markers, mirroring those of healthy mice.
This suggests that LM-20 could be a beneficial therapy for managing ulcerative colitis.
Our results were promising—mice receiving LM-20 showed an impressive 83.3% reduction in disease activity. They also had lower levels of harmful inflammatory markers, mirroring those of healthy mice.
This suggests that LM-20 could be a beneficial therapy for managing ulcerative colitis.
Read More
9
We investigated the effects of DSW3805, a probiotic isolated from Korean kimchi, on colitis in mice induced by dextran sulfate sodium.
Mice treated with DSW3805 showed improvements in gut health, as evidenced by less colonic damage and decreased inflammation markers.
We noted that the probiotics also increased beneficial bacteria ratios in the gut and produced beneficial short-chain fatty acids.
Overall, DSW3805 may serve as a functional food to enhance gut health and alleviate colitis symptoms.
Mice treated with DSW3805 showed improvements in gut health, as evidenced by less colonic damage and decreased inflammation markers.
We noted that the probiotics also increased beneficial bacteria ratios in the gut and produced beneficial short-chain fatty acids.
Overall, DSW3805 may serve as a functional food to enhance gut health and alleviate colitis symptoms.
Read More
8
Marine probiotic shows gut benefits
We explored the effects of a new probiotic, HY0110, derived from marine sources, known for its potential in gut health. In our research, HY0110 showed impressive antibacterial properties and antioxidant capacity.
In models of colitis, it helped reduce inflammation and restore a healthy gut microbiome. By enhancing important metabolic compounds, HY0110 supports immune function and inflammation regulation.
Overall, our findings indicate that HY0110 could be a promising functional food for managing inflammatory bowel disease.
In models of colitis, it helped reduce inflammation and restore a healthy gut microbiome. By enhancing important metabolic compounds, HY0110 supports immune function and inflammation regulation.
Overall, our findings indicate that HY0110 could be a promising functional food for managing inflammatory bowel disease.
Read More
Most Useful Reviews
10
No more pain
107 people found this helpful
I drink one NATOOSHCHAK capsule in the morning, and during the day, there is no pain or swelling from my 30-year-old chronic colitis. It genuinely works! The enteric-soluble capsule is a significant advantage. Keep it in the refrigerator for longevity. Check expiry dates before ordering. I throw a capsule into milk in the evening and keep it warm. I also recommend having thick kefir in the morning. Wishing you good health.
Read More
9
Keeps me well
4 people found this helpful
Initially, I tried a $35 probiotic, but I noticed no difference, so I switched to this one, which makes me feel fantastic! I have colitis, and this keeps me in remission.
Read More
9
No more significant flares
4 people found this helpful
Works well for ulcerative colitis. I've taken this daily for over a year, initially after hearing praises from forums dedicated to patients with ulcerative colitis and Crohn's. I appreciate that it doesn't require refrigeration, and I've not experienced significant flares since starting. It helps maintain my gut health and keeps me off steroids. I trust the quality and results surpass those of other brands.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.5
- All Researches
9.5
Microencapsulated LM-20 effective in colitis
We investigated the effects of microencapsulated LM-20, a probiotic, on ulcerative colitis in a lab model. Using advanced microencapsulation techniques, we ensured strong survival rates of this probiotic in harsh gastrointestinal conditions.
Our results were promising—mice receiving LM-20 showed an impressive 83.3% reduction in disease activity. They also had lower levels of harmful inflammatory markers, mirroring those of healthy mice.
This suggests that LM-20 could be a beneficial therapy for managing ulcerative colitis.
Our results were promising—mice receiving LM-20 showed an impressive 83.3% reduction in disease activity. They also had lower levels of harmful inflammatory markers, mirroring those of healthy mice.
This suggests that LM-20 could be a beneficial therapy for managing ulcerative colitis.
Read More
9
We explored how Lactobacillus might play a role in treating ulcerative colitis (UC) through various scientific methods. In our investigation, we found that Lactobacillus significantly reduced harmful inflammation markers and improved gut health in mice with UC.
Additionally, it helped increase beneficial gut bacteria and restored balance in the intestines. These findings suggest that Lactobacillus could be a promising natural treatment for managing this condition by supporting a healthier intestinal environment.
Additionally, it helped increase beneficial gut bacteria and restored balance in the intestines. These findings suggest that Lactobacillus could be a promising natural treatment for managing this condition by supporting a healthier intestinal environment.
Read More
9
We investigated the effects of DSW3805, a probiotic isolated from Korean kimchi, on colitis in mice induced by dextran sulfate sodium.
Mice treated with DSW3805 showed improvements in gut health, as evidenced by less colonic damage and decreased inflammation markers.
We noted that the probiotics also increased beneficial bacteria ratios in the gut and produced beneficial short-chain fatty acids.
Overall, DSW3805 may serve as a functional food to enhance gut health and alleviate colitis symptoms.
Mice treated with DSW3805 showed improvements in gut health, as evidenced by less colonic damage and decreased inflammation markers.
We noted that the probiotics also increased beneficial bacteria ratios in the gut and produced beneficial short-chain fatty acids.
Overall, DSW3805 may serve as a functional food to enhance gut health and alleviate colitis symptoms.
Read More
9
In our research, we explored the effectiveness of probiotic treatments for inflammatory bowel disease (IBD) using metal-phenolic networks. We focused on tea polyphenols, like gallic acid and epigallocatechin, mixed with Lactobacillus rhamnosus.
The findings showed that these new formulations significantly improved the survival rates of probiotics in the gastrointestinal tract and effectively reduced signs of ulcerative colitis. Notably, one formulation promoted beneficial bacteria growth while suppressing harmful ones. This suggests that these advanced probiotic coatings could be a game-changer in IBD therapies.
The findings showed that these new formulations significantly improved the survival rates of probiotics in the gastrointestinal tract and effectively reduced signs of ulcerative colitis. Notably, one formulation promoted beneficial bacteria growth while suppressing harmful ones. This suggests that these advanced probiotic coatings could be a game-changer in IBD therapies.
Read More
9
Lactobacillus with selenium combats colitis
We explored a new probiotic treatment for colitis using a unique blend of Lactobacillus and selenium nanoparticles. This innovative approach, designed to overcome underlying issues in colitis, targets the inflammation and dysbiosis seen in patients.
The results from our study indicated that these probiotics effectively reduced oxidative stress and improved gut health by regulating macrophage activity. This dual-action helps calm inflammation and restore balance in gut bacteria.
Overall, we saw promising effects in mice with induced colitis, but further research is needed to fully understand their benefits in humans.
The results from our study indicated that these probiotics effectively reduced oxidative stress and improved gut health by regulating macrophage activity. This dual-action helps calm inflammation and restore balance in gut bacteria.
Overall, we saw promising effects in mice with induced colitis, but further research is needed to fully understand their benefits in humans.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
No more pain
107 people found this helpful
I drink one NATOOSHCHAK capsule in the morning, and during the day, there is no pain or swelling from my 30-year-old chronic colitis. It genuinely works! The enteric-soluble capsule is a significant advantage. Keep it in the refrigerator for longevity. Check expiry dates before ordering. I throw a capsule into milk in the evening and keep it warm. I also recommend having thick kefir in the morning. Wishing you good health.
Read More
9
Keeps me well
4 people found this helpful
Initially, I tried a $35 probiotic, but I noticed no difference, so I switched to this one, which makes me feel fantastic! I have colitis, and this keeps me in remission.
Read More
9
No more significant flares
4 people found this helpful
Works well for ulcerative colitis. I've taken this daily for over a year, initially after hearing praises from forums dedicated to patients with ulcerative colitis and Crohn's. I appreciate that it doesn't require refrigeration, and I've not experienced significant flares since starting. It helps maintain my gut health and keeps me off steroids. I trust the quality and results surpass those of other brands.
Read More
9
Great for husband
A great product for a reasonable price. I've been purchasing it for four or five years. It has been very beneficial for my husband's colitis.
Read More
9
Symptoms subsided
I have irritable colitis, and since starting this, my symptoms have significantly reduced.
Read More
Frequently Asked Questions
6
Steady improvements
I've been taking this for a few months, and my irritable colitis appears to be steadily improving.
9
Great for husband
A great product for a reasonable price. I've been purchasing it for four or five years. It has been very beneficial for my husband's colitis.
9
Symptoms subsided
I have irritable colitis, and since starting this, my symptoms have significantly reduced.
9
Keeps me well
4 people found this helpful
Initially, I tried a $35 probiotic, but I noticed no difference, so I switched to this one, which makes me feel fantastic! I have colitis, and this keeps me in remission.
10
No more pain
107 people found this helpful
I drink one NATOOSHCHAK capsule in the morning, and during the day, there is no pain or swelling from my 30-year-old chronic colitis. It genuinely works! The enteric-soluble capsule is a significant advantage. Keep it in the refrigerator for longevity. Check expiry dates before ordering. I throw a capsule into milk in the evening and keep it warm. I also recommend having thick kefir in the morning. Wishing you good health.
8
Lactobacillus aids ulcerative colitis treatment
We investigated a novel approach for treating ulcerative colitis using lactobacillus acidophilus-derived extracellular vesicles. This method involves encapsulating nanoparticles with siRNA that targets the inflammatory protein TNF-α.
After testing in a model, we found that this system effectively delivers the siRNA to the colon, helping to reduce inflammation and restore gut health. Additionally, it positively influences gut microbiota composition. Overall, our findings suggest this could be a promising treatment strategy for managing ulcerative colitis, though more research is needed to fully understand its effectiveness.
After testing in a model, we found that this system effectively delivers the siRNA to the colon, helping to reduce inflammation and restore gut health. Additionally, it positively influences gut microbiota composition. Overall, our findings suggest this could be a promising treatment strategy for managing ulcerative colitis, though more research is needed to fully understand its effectiveness.
9
Lactiplantibacillus plantarum shows promise
By examining various strains of Lactiplantibacillus plantarum, we looked into how their ability to process tryptophan influences colitis treatment. In a colitis model using mice, we found that some strains struggled to improve conditions, while L. plantarum SFFI23 showed promising results.
This strain not only helped restore weight and colon integrity but also activated beneficial gut signaling pathways. A key player here was the production of indole-3-lactic acid, which appeared to enhance the gut barrier and reduce inflammation. Overall, these insights could guide personalized approaches to gut health.
This strain not only helped restore weight and colon integrity but also activated beneficial gut signaling pathways. A key player here was the production of indole-3-lactic acid, which appeared to enhance the gut barrier and reduce inflammation. Overall, these insights could guide personalized approaches to gut health.
8
Marine probiotic shows gut benefits
We explored the effects of a new probiotic, HY0110, derived from marine sources, known for its potential in gut health. In our research, HY0110 showed impressive antibacterial properties and antioxidant capacity.
In models of colitis, it helped reduce inflammation and restore a healthy gut microbiome. By enhancing important metabolic compounds, HY0110 supports immune function and inflammation regulation.
Overall, our findings indicate that HY0110 could be a promising functional food for managing inflammatory bowel disease.
In models of colitis, it helped reduce inflammation and restore a healthy gut microbiome. By enhancing important metabolic compounds, HY0110 supports immune function and inflammation regulation.
Overall, our findings indicate that HY0110 could be a promising functional food for managing inflammatory bowel disease.
9
In our research, we explored the effectiveness of probiotic treatments for inflammatory bowel disease (IBD) using metal-phenolic networks. We focused on tea polyphenols, like gallic acid and epigallocatechin, mixed with Lactobacillus rhamnosus.
The findings showed that these new formulations significantly improved the survival rates of probiotics in the gastrointestinal tract and effectively reduced signs of ulcerative colitis. Notably, one formulation promoted beneficial bacteria growth while suppressing harmful ones. This suggests that these advanced probiotic coatings could be a game-changer in IBD therapies.
The findings showed that these new formulations significantly improved the survival rates of probiotics in the gastrointestinal tract and effectively reduced signs of ulcerative colitis. Notably, one formulation promoted beneficial bacteria growth while suppressing harmful ones. This suggests that these advanced probiotic coatings could be a game-changer in IBD therapies.
9
Lactobacillus with selenium combats colitis
We explored a new probiotic treatment for colitis using a unique blend of Lactobacillus and selenium nanoparticles. This innovative approach, designed to overcome underlying issues in colitis, targets the inflammation and dysbiosis seen in patients.
The results from our study indicated that these probiotics effectively reduced oxidative stress and improved gut health by regulating macrophage activity. This dual-action helps calm inflammation and restore balance in gut bacteria.
Overall, we saw promising effects in mice with induced colitis, but further research is needed to fully understand their benefits in humans.
The results from our study indicated that these probiotics effectively reduced oxidative stress and improved gut health by regulating macrophage activity. This dual-action helps calm inflammation and restore balance in gut bacteria.
Overall, we saw promising effects in mice with induced colitis, but further research is needed to fully understand their benefits in humans.
References
- Cui C, Tang J, Chen J, Zhang B, Li R, et al. Lactobacillus acidophilus extracellular vesicles-coated UiO-66-NH@siRNA nanoparticles for ulcerative colitis targeted gene therapy and gut microbiota modulation. J Nanobiotechnology. 2025;23:301. doi:10.1186/s12951-025-03376-0
- Huang F, Yang N, Zhang Q, Luo C, Wang J, et al. Marine-Derived HY0110 as a Next-Generation Functional Food Probiotic: Comprehensive In Vitro and In Vivo Bioactivity Evaluation and Synergistic Fermentation of Extract Powder. Foods. 2025;14. doi:10.3390/foods14071181
- Zhang L, Liu X, Xu M, Cheng X, Li N, et al. L. Modulates the Intestinal Microecology to Treat DSS-Induced Ulcerative Colitis: UHPLC-OE-MS/MS, Network Pharmacology, and Experimental Validation. Foods. 2025;14. doi:10.3390/foods14071145
- Lee NK, Lee Y, Shin DS, Choi YM, Lee J, et al. Effect of DSW3805 Isolated from Kimchi for Gut Health Attenuating Colonic Inflammation in a Dextran Sulfate Sodium-Induced Mouse Model. Nutrients. 2025;17. doi:10.3390/nu17071259
- Gao L, Liu Y, Ye L, Liang S, Lin J, et al. Metal ion coordinated tea polyphenol nanocoating for enhanced probiotic therapy in inflammatory bowel disease. Biomaterials. 2025;321:123323. doi:10.1016/j.biomaterials.2025.123323
- Li P, Zhu L, Song C, Wu M, Zhu X, et al. Triple-Functional Probiotics with Intracellularly Synthesized Selenium Nanoparticles for Colitis Therapy by Regulating the Macrophage Phenotype and Modulating Gut Microbiota. ACS Nano. 2025;19:14213. doi:10.1021/acsnano.5c00574
- Fang Z, Yang X, Shang L. Microfluidic-derived montmorillonite composite microparticles for oral codelivery of probiotic biofilm and postbiotics. Sci Adv. 2025;11:eadt2131. doi:10.1126/sciadv.adt2131
- Zhou M, Yang Y, Wang Z, Gao Y, Dang D, et al. Effect of Recombinant Tuxtide Intervention on DSS-induced Acute UC Mouse Model. Curr Top Med Chem. 2025. doi:10.2174/0115680266343609250226094349
- Garfias Noguez C, Ramírez Damián M, Ortiz Moreno A, Márquez Flores YK, Alamilla Beltrán L, et al. Microencapsulation and Probiotic Characterization of LM-20: Therapeutic Application in a Murine Model of Ulcerative Colitis. Nutrients. 2025;17. doi:10.3390/nu17050749
- Wang Y, Li T, Dong Z, Zhang Q, Mi J, et al. Extracellular Vesicles From Lactobacillus fermentum Enhance Intestinal Barrier Integrity and Restore Gut Microbial Homeostasis in Experimental Murine Colitis. J Nutr. 2025. doi:10.1016/j.tjnut.2025.03.001
- Gong GZ, Li RT, Cui SS, Zhu YT, Duan ZZ, et al. Synbiotic yacon juice fermented by Lactiplantibacillus plantarum QS7T attenuates dextran sodium sulfate-induced ulcerative colitis in mice. J Food Sci. 2025;90:e17478. doi:10.1111/1750-3841.17478
- Zuo X, Zhang T, Dong X, Liu J, Liu Y. Identification of the key tryptophan metabolic characteristics of Lactiplantibacillus plantarum for aryl hydrocarbon receptor activation and ulcerative colitis alleviation. Food Res Int. 2025;203:115766. doi:10.1016/j.foodres.2025.115766
- Kang YY, Song HJ, Park SY, Oh DN, Kim GY, et al. Comparative Effects of Probiotics and Paraprobiotics Derived from , , and in a DSS-Induced Ulcerative Colitis Mouse Model. J Microbiol Biotechnol. 2025;35:e2411045. doi:10.4014/jmb.2411.11045
- Wang Z, Liu T, Liu L, Xie J, Tang F, et al. Lactobacillus vaginalis alleviates DSS induced colitis by regulating the gut microbiota and increasing the production of 3-indoleacrylic acid. Pharmacol Res. 2025;213:107663. doi:10.1016/j.phrs.2025.107663
- Pan H, Yang S, Kulyar MF, Ma H, Li K, et al. 016 Alleviates Mice Colitis by Modulating Oxidative Stress, Gut Microbiota, and Microbial Metabolism. Nutrients. 2025;17. doi:10.3390/nu17030452
- Shao J, Xia Y, Wang G, Xiong Z, Yang Y, et al. The bsh1 gene of Lactobacillus plantarum AR113 ameliorates liver injury in colitis mice. NPJ Sci Food. 2025;9:22. doi:10.1038/s41538-025-00373-3
