' 
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Questionable
Based on 7 Reviews
5.5
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Acetyl-L-Carnitine (from Acetyl-L-Carnitine HCl)
1 g (1,000 mg)
**
Top Medical Research Studies
8
Acetyl-L-Carnitine affects hypothyroidism
Acetyl-L-carnitine increases cytochrome oxidase subunit I mRNA content in hypothyroid rat liver.
Study relevance score: 8
We examined how acetyl-L-carnitine influences hypothyroidism, particularly focusing on its impact on liver mitochondria. In our study, we measured the amount of messenger RNA for cytochrome oxidase subunit I in the livers of hypothyroid rats.
After treating the rats with acetyl-L-carnitine, we observed a significant increase in the mRNA levels just three hours post-treatment. This improvement in gene expression suggests that acetyl-L-carnitine may promote mitochondrial function even in altered metabolic states.
Interestingly, even rats that were pre-treated with T3, a thyroid hormone, showed similar positive effects when administered acetyl-L-carnitine. These findings lend further support to the idea that acetyl-L-carnitine can stimulate important processes in mitochondria, especially under conditions like hypothyroidism.
After treating the rats with acetyl-L-carnitine, we observed a significant increase in the mRNA levels just three hours post-treatment. This improvement in gene expression suggests that acetyl-L-carnitine may promote mitochondrial function even in altered metabolic states.
Interestingly, even rats that were pre-treated with T3, a thyroid hormone, showed similar positive effects when administered acetyl-L-carnitine. These findings lend further support to the idea that acetyl-L-carnitine can stimulate important processes in mitochondria, especially under conditions like hypothyroidism.
Read More
Most Useful Reviews
0
Interferes with Synthroid
Not suitable for those on hypothyroidism medication. I felt odd within days of using this. Research revealed it interfered with Synthroid. I utilise Amazon's reviews, so I thought I’d share this in case anyone is considering it for hypothyroidism-related fatigue. Good luck on your health journey!
Read More
9.5
Feeling better
I started taking this on my endocrinologist's advice for hypothyroidism, and I feel significantly better now.
Read More
2.3
Dopamine overload
Warning: This supplement may lead to dopamine overload in some individuals – it triggered a severe depressive and anxious episode for me, which I managed with 5-HTP. It can also affect thyroid function and lead to symptoms of hypothyroidism, which I am currently experiencing. Note that ALCAR has a long half-life of 28.9 - 35.9 hours, resulting in quick accumulation in the body.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
Acetyl-L-Carnitine affects hypothyroidism
Acetyl-L-carnitine increases cytochrome oxidase subunit I mRNA content in hypothyroid rat liver.
Study relevance score: 8
We examined how acetyl-L-carnitine influences hypothyroidism, particularly focusing on its impact on liver mitochondria. In our study, we measured the amount of messenger RNA for cytochrome oxidase subunit I in the livers of hypothyroid rats.
After treating the rats with acetyl-L-carnitine, we observed a significant increase in the mRNA levels just three hours post-treatment. This improvement in gene expression suggests that acetyl-L-carnitine may promote mitochondrial function even in altered metabolic states.
Interestingly, even rats that were pre-treated with T3, a thyroid hormone, showed similar positive effects when administered acetyl-L-carnitine. These findings lend further support to the idea that acetyl-L-carnitine can stimulate important processes in mitochondria, especially under conditions like hypothyroidism.
After treating the rats with acetyl-L-carnitine, we observed a significant increase in the mRNA levels just three hours post-treatment. This improvement in gene expression suggests that acetyl-L-carnitine may promote mitochondrial function even in altered metabolic states.
Interestingly, even rats that were pre-treated with T3, a thyroid hormone, showed similar positive effects when administered acetyl-L-carnitine. These findings lend further support to the idea that acetyl-L-carnitine can stimulate important processes in mitochondria, especially under conditions like hypothyroidism.
Read More
User Reviews
USERS' SCORE
Questionable
Based on 7 Reviews
5.5
- All Reviews
- Positive Reviews
- Negative Reviews
0
Interferes with Synthroid
Not suitable for those on hypothyroidism medication. I felt odd within days of using this. Research revealed it interfered with Synthroid. I utilise Amazon's reviews, so I thought I’d share this in case anyone is considering it for hypothyroidism-related fatigue. Good luck on your health journey!
Read More
9.5
Feeling better
I started taking this on my endocrinologist's advice for hypothyroidism, and I feel significantly better now.
2.3
Dopamine overload
Warning: This supplement may lead to dopamine overload in some individuals – it triggered a severe depressive and anxious episode for me, which I managed with 5-HTP. It can also affect thyroid function and lead to symptoms of hypothyroidism, which I am currently experiencing. Note that ALCAR has a long half-life of 28.9 - 35.9 hours, resulting in quick accumulation in the body.
Read More
8.8
Increased energy
Excellent! While some individuals may not respond well to hypothyroidism, I appreciate it as it boosts my energy levels. The size is also convenient to consume.
8.8
Necessary supplement
I came across a physician's blog stating that this is an essential supplement for individuals with hypothyroidism due to their slow metabolism. L-carnitine enhances energy in cells, and I intend to start taking it.
