Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.3
USERS' SCORE
Good
Based on 9 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₆ (as Pyridoxal 5-Phosphate)
2.5 mg
147%
Folate (800 mcg as 6S)-5MTHF-Methyltetrahydrofolate Glucosamine Salt)
1,360 mcg DFE‡
340%
Vitamin B12 (as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
9
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Read More
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
Read More
7
We engaged in a double-blind study involving 478 young adults to explore the effects of high-dose Vitamin B6 and B12 supplementation on anxiety levels. Over a month of treatment, we compared these vitamin supplements against a placebo, focusing on their potential to balance neural inhibition and excitation—two processes crucial for emotional regulation.
Our findings revealed that participants who took Vitamin B6 reported lower levels of anxiety compared to those on the placebo. Interestingly, there was a trend suggesting a mild reduction in depression as well. Additionally, we noticed that Vitamin B6 enhanced a specific measure known as surround suppression of visual contrast detection, hinting at its role in increasing neural inhibition.
Conversely, while Vitamin B12 also showed some trends towards influencing anxiety and visual processing, the results were not as pronounced or reliable as those observed with Vitamin B6. Overall, our results underline the potential of high-dose Vitamin B6 supplementation in reducing anxiety and strengthening the brain's inhibitory functions, tying back to its known involvement in GABA synthesis.
Our findings revealed that participants who took Vitamin B6 reported lower levels of anxiety compared to those on the placebo. Interestingly, there was a trend suggesting a mild reduction in depression as well. Additionally, we noticed that Vitamin B6 enhanced a specific measure known as surround suppression of visual contrast detection, hinting at its role in increasing neural inhibition.
Conversely, while Vitamin B12 also showed some trends towards influencing anxiety and visual processing, the results were not as pronounced or reliable as those observed with Vitamin B6. Overall, our results underline the potential of high-dose Vitamin B6 supplementation in reducing anxiety and strengthening the brain's inhibitory functions, tying back to its known involvement in GABA synthesis.
Read More
Most Useful Reviews
10
No more anxiety
51 people found this helpful
No more insomnia, anxiety, or depression! I have homozygous MTHFR C677T, along with a history of anxiety, depression, and insomnia. After trying numerous medicines and therapies without success, I reluctantly tried methylated B vitamins. Remarkably, within a week, I began sleeping well, and both my anxiety and depressive feelings dissipated. This has been a life-changing treatment for me!
Read More
9
Improves anxiety
1 people found this helpful
Wonderful vitamin, excellent quality, greatly improves anxiety and depression. I took it and loved the result. Super recommended.
Read More
9
Alleviated anxiety
1 people found this helpful
Methylfolate significantly helped my anxiety and mild depressive tendencies. Although I'm not on any SSRIs, methylfolate has proven effective for me.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.3
- All Researches
9
Our investigation aimed to understand how vitamin B6 might influence anxiety, particularly among individuals facing mental health challenges like depression and stress. We assessed the mental health of 82 gastric cancer patients compared to 95 healthy individuals, using a questionnaire that evaluated their levels of anxiety and depression.
Interestingly, our findings showed a noteworthy link between vitamin B6 intake and decreased anxiety levels among those with depression. Specifically, vitamin B6 emerged as a significant protective factor, suggesting that higher intake could help reduce anxiety symptoms. This trend underscores the potential importance of certain dietary choices in managing mental health.
Our study also highlighted that other dietary factors could affect mental health. For instance, sugar and salt were found to increase anxiety risks, while foods rich in vitamins, minerals, and phytochemicals were associated with lower incidences of stress and depression. This points to the broader picture that healthy eating patterns may assist in fostering mental well-being and, in turn, impact conditions like gastric cancer.
However, while these initial findings are promising, we acknowledge the need for further research to fully understand these relationships and the underlying mechanisms involved. The interplay between diet, mental health, and physical health, such as cancer risks, is complex and warrants deeper exploration.
Interestingly, our findings showed a noteworthy link between vitamin B6 intake and decreased anxiety levels among those with depression. Specifically, vitamin B6 emerged as a significant protective factor, suggesting that higher intake could help reduce anxiety symptoms. This trend underscores the potential importance of certain dietary choices in managing mental health.
Our study also highlighted that other dietary factors could affect mental health. For instance, sugar and salt were found to increase anxiety risks, while foods rich in vitamins, minerals, and phytochemicals were associated with lower incidences of stress and depression. This points to the broader picture that healthy eating patterns may assist in fostering mental well-being and, in turn, impact conditions like gastric cancer.
However, while these initial findings are promising, we acknowledge the need for further research to fully understand these relationships and the underlying mechanisms involved. The interplay between diet, mental health, and physical health, such as cancer risks, is complex and warrants deeper exploration.
Read More
9
We investigated the impact of prenatal exposure to pyridaben, a common pesticide, on anxiety-like behaviors in offspring. Pregnant mice were given pyridaben, and later, we observed that the exposed offspring displayed increased anxiety levels at five weeks of age.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Our analysis looked into the underlying biological mechanisms and revealed a disruption in vitamin B6 metabolism. Particularly, we found a significant reduction in pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, which plays a crucial role in brain function. Additionally, the levels of GABA, a neurotransmitter that helps regulate anxiety, were also found to be lower in the brains of these offspring.
To see if vitamin B6 could alleviate this anxiety, we administered PLP directly to the affected offspring. Remarkably, we observed an improvement in anxiety-like behaviors following the treatment. This suggests that restoring PLP levels could potentially offset the negative impacts of prenatal pesticide exposure on neurodevelopment, particularly regarding anxiety.
Overall, our findings indicate a meaningful link between vitamin B6 and anxiety, highlighting its importance in developing healthy brain function, especially in the context of environmental stressors.
Read More
8
We conducted a clinical trial that looked into whether vitamin B6 could help prevent postpartum depression (PPD) among mothers at risk. This single-blind, placebo-controlled study involved 81 pregnant women in Isfahan, Iran, who were divided into two groups—one group received 80 mg of vitamin B6, while the other received a placebo.
Participants were assessed for their risk of developing PPD using a series of structured questionnaires. After the intervention, we measured the depression levels again, and while vitamin B6 showed promise in reducing PPD scores in these women, it was not specifically tested for anxiety.
The results indicated that mothers taking vitamin B6 had significantly lower depression scores after the intervention compared to those taking the placebo. However, it's important to note that this study did not directly measure the impact of vitamin B6 on anxiety levels, which somewhat limits its application for anxiety disorders. Overall, these findings suggest that while vitamin B6 can help in reducing symptoms of PPD, its benefits for anxiety specifically remain unclear.
Participants were assessed for their risk of developing PPD using a series of structured questionnaires. After the intervention, we measured the depression levels again, and while vitamin B6 showed promise in reducing PPD scores in these women, it was not specifically tested for anxiety.
The results indicated that mothers taking vitamin B6 had significantly lower depression scores after the intervention compared to those taking the placebo. However, it's important to note that this study did not directly measure the impact of vitamin B6 on anxiety levels, which somewhat limits its application for anxiety disorders. Overall, these findings suggest that while vitamin B6 can help in reducing symptoms of PPD, its benefits for anxiety specifically remain unclear.
Read More
8
Magnesium and B6 improve anxiety
We explored how magnesium and vitamin B6 affect anxiety in adults dealing with significant stress. In a study that lasted eight weeks, participants who were experiencing high levels of stress were given either a combination of magnesium and vitamin B6 or magnesium alone.
Both groups showed reductions in their anxiety scores, particularly in the first four weeks. However, the combination of magnesium with vitamin B6 appeared to provide better results for participants' perceived ability to engage in physical activities by the end of the fourth week.
Although both treatments were helpful in easing anxiety levels, it's important to note that we cannot definitively isolate the effects of vitamin B6 from magnesium, as the study examined them together. Overall, this suggests that magnesium supplementation, with or without vitamin B6, may offer a meaningful improvement in mental wellness for those dealing with stress.
Both groups showed reductions in their anxiety scores, particularly in the first four weeks. However, the combination of magnesium with vitamin B6 appeared to provide better results for participants' perceived ability to engage in physical activities by the end of the fourth week.
Although both treatments were helpful in easing anxiety levels, it's important to note that we cannot definitively isolate the effects of vitamin B6 from magnesium, as the study examined them together. Overall, this suggests that magnesium supplementation, with or without vitamin B6, may offer a meaningful improvement in mental wellness for those dealing with stress.
Read More
8
We examined a clinical trial designed to understand how the combination of magnesium and vitamin B6 affects stress levels in healthy adults suffering from low magnesium levels. Participants were assessed using a standard stress scale, and they either received a magnesium and vitamin B6 supplement together or magnesium alone.
Over the trial, we found that while both groups experienced a notable reduction in stress, the addition of vitamin B6 did not significantly outperform magnesium on its own. More specifically, those with severe stress did show improvements when taking both supplements compared to just magnesium, but it was a modest benefit.
Overall, these results indicate that magnesium effectively helps reduce stress levels, with a small potential advantage when it comes to combining it with vitamin B6 in more stressed individuals. Nevertheless, it’s clear that on its own, magnesium remains a powerful option for managing stress.
Over the trial, we found that while both groups experienced a notable reduction in stress, the addition of vitamin B6 did not significantly outperform magnesium on its own. More specifically, those with severe stress did show improvements when taking both supplements compared to just magnesium, but it was a modest benefit.
Overall, these results indicate that magnesium effectively helps reduce stress levels, with a small potential advantage when it comes to combining it with vitamin B6 in more stressed individuals. Nevertheless, it’s clear that on its own, magnesium remains a powerful option for managing stress.
Read More
User Reviews
USERS' SCORE
Good
Based on 9 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
10
No more anxiety
51 people found this helpful
No more insomnia, anxiety, or depression! I have homozygous MTHFR C677T, along with a history of anxiety, depression, and insomnia. After trying numerous medicines and therapies without success, I reluctantly tried methylated B vitamins. Remarkably, within a week, I began sleeping well, and both my anxiety and depressive feelings dissipated. This has been a life-changing treatment for me!
Read More
9
Improves anxiety
1 people found this helpful
Wonderful vitamin, excellent quality, greatly improves anxiety and depression. I took it and loved the result. Super recommended.
Read More
9
Alleviated anxiety
1 people found this helpful
Methylfolate significantly helped my anxiety and mild depressive tendencies. Although I'm not on any SSRIs, methylfolate has proven effective for me.
Read More
9
Relieves tension
One of the best. It relieves anxiety and tension. The quality is exceptional, and the size is small. I have enough energy for the entire day, and the packaging is convenient.
Read More
9
Strengthens nerves
An excellent remedy for strengthening the nervous system and alleviating feelings of anxiety.
Read More
Frequently Asked Questions
9
Improves anxiety
1 people found this helpful
Wonderful vitamin, excellent quality, greatly improves anxiety and depression. I took it and loved the result. Super recommended.
9
Relieves tension
One of the best. It relieves anxiety and tension. The quality is exceptional, and the size is small. I have enough energy for the entire day, and the packaging is convenient.
7.5
Improves sleep
This is the best complex of B vitamins, containing the essential B6, B9, and B12 in the correct methyl forms. It reduces anxiety, lowers homocysteine levels and improves sleep. The brand is excellent, and I take it in courses twice to three times a year.
9
Strengthens nerves
An excellent remedy for strengthening the nervous system and alleviating feelings of anxiety.
7
We engaged in a double-blind study involving 478 young adults to explore the effects of high-dose Vitamin B6 and B12 supplementation on anxiety levels. Over a month of treatment, we compared these vitamin supplements against a placebo, focusing on their potential to balance neural inhibition and excitation—two processes crucial for emotional regulation.
Our findings revealed that participants who took Vitamin B6 reported lower levels of anxiety compared to those on the placebo. Interestingly, there was a trend suggesting a mild reduction in depression as well. Additionally, we noticed that Vitamin B6 enhanced a specific measure known as surround suppression of visual contrast detection, hinting at its role in increasing neural inhibition.
Conversely, while Vitamin B12 also showed some trends towards influencing anxiety and visual processing, the results were not as pronounced or reliable as those observed with Vitamin B6. Overall, our results underline the potential of high-dose Vitamin B6 supplementation in reducing anxiety and strengthening the brain's inhibitory functions, tying back to its known involvement in GABA synthesis.
Our findings revealed that participants who took Vitamin B6 reported lower levels of anxiety compared to those on the placebo. Interestingly, there was a trend suggesting a mild reduction in depression as well. Additionally, we noticed that Vitamin B6 enhanced a specific measure known as surround suppression of visual contrast detection, hinting at its role in increasing neural inhibition.
Conversely, while Vitamin B12 also showed some trends towards influencing anxiety and visual processing, the results were not as pronounced or reliable as those observed with Vitamin B6. Overall, our results underline the potential of high-dose Vitamin B6 supplementation in reducing anxiety and strengthening the brain's inhibitory functions, tying back to its known involvement in GABA synthesis.
7
We evaluated the effects of a combination treatment that included magnesium, vitamin B6, and several other ingredients on managing anxiety levels in chronically stressed individuals. In this study, adults who had experienced stress for at least one month were randomly divided into two groups. One group received the treatment while the other received a placebo, allowing us to measure the impact more accurately.
Over a 28-day period, we observed significant improvements in stress levels particularly in the group taking the vitamin and nutrient blend. The results showed a notable reduction in stress scores, suggesting that the combination treatment, including vitamin B6, could play a role in alleviating anxiety symptoms in these participants.
Additionally, it appeared that participants experienced improvements in sleep and pain perception. However, it’s essential to note that since vitamin B6 was part of a combination treatment, we couldn’t determine its isolated impact on anxiety. Therefore, while promising results emerged, further research would be needed to clarify the specific contributions of vitamin B6 in managing anxiety.
Over a 28-day period, we observed significant improvements in stress levels particularly in the group taking the vitamin and nutrient blend. The results showed a notable reduction in stress scores, suggesting that the combination treatment, including vitamin B6, could play a role in alleviating anxiety symptoms in these participants.
Additionally, it appeared that participants experienced improvements in sleep and pain perception. However, it’s essential to note that since vitamin B6 was part of a combination treatment, we couldn’t determine its isolated impact on anxiety. Therefore, while promising results emerged, further research would be needed to clarify the specific contributions of vitamin B6 in managing anxiety.
7
In our trial, we evaluated how vitamin B6 combined with L-Theanine can assist children and teenagers with Tourette syndrome who experience anxiety symptoms. The study involved 34 participants, mostly boys, aged between 4 and 17 years. These young individuals were either given nutritional supplements featuring L-Theanine and vitamin B6 or underwent psychoeducation (PE).
We observed that supplementing with both L-Theanine and vitamin B6 showed promise in reducing tics associated with anxiety. However, significant improvements were mainly seen in tic severity rather than anxiety itself. It’s essential to highlight that while we did not isolate the specific effects of vitamin B6 alone, the findings suggest potential benefits in addressing tic disorders, particularly alongside anxious symptoms.
Ultimately, the results point to possible avenues for future exploration. More research, especially placebo-controlled studies, would be helpful to understand how these supplements may work independently or together in treating anxiety and tic disorders.
We observed that supplementing with both L-Theanine and vitamin B6 showed promise in reducing tics associated with anxiety. However, significant improvements were mainly seen in tic severity rather than anxiety itself. It’s essential to highlight that while we did not isolate the specific effects of vitamin B6 alone, the findings suggest potential benefits in addressing tic disorders, particularly alongside anxious symptoms.
Ultimately, the results point to possible avenues for future exploration. More research, especially placebo-controlled studies, would be helpful to understand how these supplements may work independently or together in treating anxiety and tic disorders.
3
We investigated how vitamin B6, or pyridoxine, affects anxiety treatment when combined with diazepam, a well-known anti-anxiety medication. Our study used established methods in a controlled setting, including tests like the elevated plus maze and the light/dark box in experimental mice.
While we observed that diazepam (at 2 mg/kg) provided an anxiolytic effect, increasing key brain components like GABA and GAD, adding vitamin B6 to the treatment completely negated this benefit. This is a significant finding, as it suggests that vitamin B6 does not enhance the anxiolytic properties of diazepam and instead seems to undermine its effect.
Furthermore, we found that while diazepam showed promise, fluoxetine, another medication tested, appeared to worsen anxiety without impacting brain GABA levels. Thus, our results highlight the complex roles that various treatments can play in anxiety management and caution against relying solely on vitamin B6 in combination therapies.
While we observed that diazepam (at 2 mg/kg) provided an anxiolytic effect, increasing key brain components like GABA and GAD, adding vitamin B6 to the treatment completely negated this benefit. This is a significant finding, as it suggests that vitamin B6 does not enhance the anxiolytic properties of diazepam and instead seems to undermine its effect.
Furthermore, we found that while diazepam showed promise, fluoxetine, another medication tested, appeared to worsen anxiety without impacting brain GABA levels. Thus, our results highlight the complex roles that various treatments can play in anxiety management and caution against relying solely on vitamin B6 in combination therapies.
8
We conducted a clinical trial that looked into whether vitamin B6 could help prevent postpartum depression (PPD) among mothers at risk. This single-blind, placebo-controlled study involved 81 pregnant women in Isfahan, Iran, who were divided into two groups—one group received 80 mg of vitamin B6, while the other received a placebo.
Participants were assessed for their risk of developing PPD using a series of structured questionnaires. After the intervention, we measured the depression levels again, and while vitamin B6 showed promise in reducing PPD scores in these women, it was not specifically tested for anxiety.
The results indicated that mothers taking vitamin B6 had significantly lower depression scores after the intervention compared to those taking the placebo. However, it's important to note that this study did not directly measure the impact of vitamin B6 on anxiety levels, which somewhat limits its application for anxiety disorders. Overall, these findings suggest that while vitamin B6 can help in reducing symptoms of PPD, its benefits for anxiety specifically remain unclear.
Participants were assessed for their risk of developing PPD using a series of structured questionnaires. After the intervention, we measured the depression levels again, and while vitamin B6 showed promise in reducing PPD scores in these women, it was not specifically tested for anxiety.
The results indicated that mothers taking vitamin B6 had significantly lower depression scores after the intervention compared to those taking the placebo. However, it's important to note that this study did not directly measure the impact of vitamin B6 on anxiety levels, which somewhat limits its application for anxiety disorders. Overall, these findings suggest that while vitamin B6 can help in reducing symptoms of PPD, its benefits for anxiety specifically remain unclear.
8
This study investigated how folic acid (FA), a vitamin commonly recommended during pregnancy, can support mental health by reducing anxiety and depression symptoms. We looked at the effects of FA in a mouse model subjected to postnatal immune activation—an event known to increase the likelihood of developing neuropsychiatric disorders later in life.
We found that treating neonatal mice with folic acid improved their anxiety-like and depressive behaviors as adults. This was accompanied by a notable decrease in activated glial cells, which are brain cells associated with inflammatory responses. Specifically, those receiving folic acid showed fewer signs of inflammation in key brain areas involved in mood regulation.
An exciting part of our findings is that folic acid not only helped reduce anxiety but also appears to do so through intricate mechanisms at the cellular level. For instance, it enhanced the production of beneficial proteins in astrocytes while modifying specific gene regulation in microglia. This indicates that FA could be a promising option for mitigating mood disorders stemming from early-life stressors.
Overall, our research adds to the growing body of evidence that folate could be a vital tool in combating anxiety and mood imbalances, particularly when administered during critical periods of brain development.
We found that treating neonatal mice with folic acid improved their anxiety-like and depressive behaviors as adults. This was accompanied by a notable decrease in activated glial cells, which are brain cells associated with inflammatory responses. Specifically, those receiving folic acid showed fewer signs of inflammation in key brain areas involved in mood regulation.
An exciting part of our findings is that folic acid not only helped reduce anxiety but also appears to do so through intricate mechanisms at the cellular level. For instance, it enhanced the production of beneficial proteins in astrocytes while modifying specific gene regulation in microglia. This indicates that FA could be a promising option for mitigating mood disorders stemming from early-life stressors.
Overall, our research adds to the growing body of evidence that folate could be a vital tool in combating anxiety and mood imbalances, particularly when administered during critical periods of brain development.
References
- Vahid F, Rahmani W, Davoodi SH, Bohn T. Mental Health Conditions, Including Depression and Stress, Are Associated with Increased Odds of Gastric Cancer-Insights into the Role of Diet: A Case-Control Study. Nutrients. 2023;15. 10.3390/nu15234981
- Ding X, Wen Y, Ma X, Zhang Y, Cheng Y, et al. Pyridoxal 5'-phosphate alleviates prenatal pyridaben exposure-induced anxiety-like behaviors in offspring. Environ Sci Ecotechnol. 2023;13:100224. 10.1016/j.ese.2022.100224
- Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37:e2852. 10.1002/hup.2852
- Noah L, Morel V, Bertin C, Pouteau E, Macian N, et al. Effect of a Combination of Magnesium, B Vitamins, Rhodiola, and Green Tea (L-Theanine) on Chronically Stressed Healthy Individuals-A Randomized, Placebo-Controlled Study. Nutrients. 2022;14. 10.3390/nu14091863
- Rizzo R, Prato A, Scerbo M, Saia F, Barone R, et al. Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study. Nutrients. 2022;14. 10.3390/nu14040852
- Khodadad M, Bahadoran P, Kheirabadi GR, Sabzghabaee AM. Can Vitamin B6 Help to Prevent Postpartum Depression? A Randomized Controlled Trial. Int J Prev Med. 2021;12:136. 10.4103/ijpvm.IJPVM_240_19
- Noah L, Dye L, Bois De Fer B, Mazur A, Pickering G, et al. Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial. Stress Health. 2021;37:1000. 10.1002/smi.3051
- Walia V, Garg C, Garg M. Lithium potentiated, pyridoxine abolished and fluoxetine attenuated the anxiolytic effect of diazepam in mice. Brain Res Bull. 2019;150:343. 10.1016/j.brainresbull.2019.06.008
- Kafeshani M, Feizi A, Esmaillzadeh A, Keshteli AH, Afshar H, et al. Higher vitamin B intake is associated with lower depression and anxiety risk in women but not in men: A large cross-sectional study. Int J Vitam Nutr Res. 2020;90:484. 10.1024/0300-9831/a000589
- Pouteau E, Kabir-Ahmadi M, Noah L, Mazur A, Dye L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13:e0208454. 10.1371/journal.pone.0208454
- Ni WH, Wang K, Wang Y, Lu J, Lu CT, et al. Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats. Neuropharmacology. 2025;269:110352. 10.1016/j.neuropharm.2025.110352
- Marinina KS, Bezprozvanny IB, Egorova PA. A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice. Hum Mol Genet. 2024;33:1406. 10.1093/hmg/ddae079
- Rezaei Moghadam M, Khoshrou A, Kakhki S, Hosseini SH, Shirinzadeh Feizabadi A, et al. Folic Acid Ameliorates Anxiety- and Depressive-Like Behavior Induced by Nicotine Withdrawal Through Restoration of Behavioral and Biochemical Alterations in Adolescent Male Rats. Nicotine Tob Res. 2024;26:733. 10.1093/ntr/ntad227
- Marengo L, Barey A, Salguero A, Fabio MC, Cendán CM, et al. Neurobehavioral alterations induced by third-trimester gestation-equivalent ethanol exposure are inhibited by folate administration. Dev Psychobiol. 2023;65:e22426. 10.1002/dev.22426
- de Carvalho J, Lerner A, Feingold D. Management of Hyperhomocysteinemia, Low Vitamin Levels, and Low Cortisol in Cannabis Users: A Report of 2 Cases. J Chiropr Med. 2022;21:322. 10.1016/j.jcm.2022.03.001
- Zhao T, Wu D, Du J, Liu G, Ji G, et al. Folic Acid Attenuates Glial Activation in Neonatal Mice and Improves Adult Mood Disorders Through Epigenetic Regulation. Front Pharmacol. 2022;13:818423. 10.3389/fphar.2022.818423
- Nahar M, Rai R, Jat D. Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach. Int J Neurosci. 2024. 10.1080/00207454.2024.2398564
- Hu Y, Yu M, Wang Y, Wu H, Yang X, et al. Exploring the Association between Serum B Vitamins, Homocysteine and Mental Disorders: Insights from Mendelian Randomization. Nutrients. 2024;16. 10.3390/nu16131986
- Tan Y, Zhou L, Huang J, Chen X, Wu Y, et al. Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms. Neuropsychiatr Dis Treat. 2023;19:785. 10.2147/NDT.S399378
- Gharibpoor F, Ghavidel-Parsa B, Sattari N, Bidari A, Nejatifar F, et al. Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study. BMC Rheumatol. 2022;6:51. 10.1186/s41927-022-00282-y
