Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.5
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.5
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Folate (400 mcg as (6S)-5-MTHF [(6S)-5-Methyltetrahydrofolate Glucosamine Salt)
680 mcg DFE‡
170%
Top Medical Research Studies
9
We developed a folic acid-targeted liposome system to improve the delivery of sorafenib, a drug used in treating liver cancer. Through various techniques, we created liposomes loaded with sorafenib and evaluated their effects on liver cancer cells. Our results showed that this targeted system effectively inhibited cancer cell growth and induced apoptosis in vitro. Additionally, in a liver xenograft model, it successfully slowed tumor progression. Overall, our findings suggest that this targeted delivery method could enhance liver cancer therapy while minimizing side effects.
Read More
9
Folate-targeted nanoparticle therapy
We explored the potential of mesoporous silica nanoparticles (MSNs) enhanced with folic acid (FA) to deliver the chemotherapy drug epirubicin (EPI) effectively in breast cancer treatment.
Our research showed that this targeted delivery system significantly inhibited cancer cell growth both in laboratory settings and in mice. Notably, it encouraged cancer cell death through various molecular pathways while avoiding toxicity in other organs.
These findings suggest that folic acid's targeting ability may greatly enhance the effectiveness of anticancer therapies like epirubicin.
Our research showed that this targeted delivery system significantly inhibited cancer cell growth both in laboratory settings and in mice. Notably, it encouraged cancer cell death through various molecular pathways while avoiding toxicity in other organs.
These findings suggest that folic acid's targeting ability may greatly enhance the effectiveness of anticancer therapies like epirubicin.
Read More
9
We explored innovative ways to improve cancer treatment by using folate-targeted nanoparticles. The study focused on the development of chitosan nanoparticles that mimic cell membranes, enhancing their ability to evade the immune system and prolong circulation in the body. By integrating folate, a nutrient known to target cancer cells, we hoped to increase the effectiveness of drug delivery directly to tumors.
Our findings revealed that these folate-targeted nanoparticles showed a remarkable capacity to be absorbed by breast cancer cells, specifically increasing uptake efficiency by five to six times compared to nanoparticles without folate. This was a significant boost, showcasing the potential of using folate as a guiding factor for cancer treatment.
Furthermore, the study demonstrated that these nanoparticles remained in the bloodstream for much longer, with their half-life extended from roughly 2.7 hours to nearly 13 hours. This means they can circulate longer and potentially reach tumors more effectively.
Ultimately, our research aims to pave the way for more efficient cancer therapies, highlighting how leveraging folate in nanoparticle design may provide a promising strategy in the fight against cancer.
Our findings revealed that these folate-targeted nanoparticles showed a remarkable capacity to be absorbed by breast cancer cells, specifically increasing uptake efficiency by five to six times compared to nanoparticles without folate. This was a significant boost, showcasing the potential of using folate as a guiding factor for cancer treatment.
Furthermore, the study demonstrated that these nanoparticles remained in the bloodstream for much longer, with their half-life extended from roughly 2.7 hours to nearly 13 hours. This means they can circulate longer and potentially reach tumors more effectively.
Ultimately, our research aims to pave the way for more efficient cancer therapies, highlighting how leveraging folate in nanoparticle design may provide a promising strategy in the fight against cancer.
Read More
Most Useful Reviews
9
Has anticancer properties
Methylfolate, the active form of folic acid, crosses the blood-brain barrier to promote a healthy nervous system. It supports cardiovascular health by managing homocysteine levels, which are linked to heart disease. Methylfolate aids in the production of essential neurotransmitters and improves mood. It positively affects cognitive functions and has been shown to have anticancer effects against various tumours, including cervical and colorectal cancers.
Read More
6
Essential for growth
21 people found this helpful
Folic acid B9 is vital for the bone marrow, aiding neurotransmitter synthesis to regulate appetite, sleep, and mood while reducing cancer risk. Daily intake before and during the first three months of pregnancy is vital for the child's development and preventing anaemia in pregnant women. It's also beneficial after 40, improving sleep, memory, blood pressure stability, and reducing diabetes risk while enhancing skin and hair health.
Read More
6
Prevent neural issues
1 people found this helpful
Folic acid is crucial during pregnancy planning to prevent neural tube defects. It is beneficial in treating certain types of anaemia and aids in developing the circulatory system while helping to prevent cancer. I take one capsule daily after meals to support these needs.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 22 Researches
8.5
- All Researches
9.5
Nanoparticle-assisted targeted cancer therapy
We explored the use of nanosecond laser pulses combined with doxorubicin-loaded gold nanoparticles (AuNPs) to target folate receptor-positive cancer cells. This innovative method allowed for the efficient release of the drug while inducing localized cell damage through thermal effects.
By testing different nanoparticle concentrations and laser settings, we observed near-complete tumor cell destruction in pinpointed areas, sparing nearby healthy cells. The results emphasized the potential of this approach for developing safer and more effective cancer therapies.
By testing different nanoparticle concentrations and laser settings, we observed near-complete tumor cell destruction in pinpointed areas, sparing nearby healthy cells. The results emphasized the potential of this approach for developing safer and more effective cancer therapies.
Read More
9.5
We examined a new approach to enhance cancer treatment by developing targeted nanogels using folic acid to deliver 5-aminolevulinic acid (5-ALA) more effectively.
By using special nanoparticles, we found that these nanogels significantly improved the delivery of 5-ALA to tumor cells, enhancing the effectiveness of photodynamic therapy.
Our in vivo experiments indicated that these nanogels notably reduced the growth of skin cancer.
Overall, this innovative delivery system shows great promise in boosting the therapeutic effects of 5-ALA against skin cancer.
By using special nanoparticles, we found that these nanogels significantly improved the delivery of 5-ALA to tumor cells, enhancing the effectiveness of photodynamic therapy.
Our in vivo experiments indicated that these nanogels notably reduced the growth of skin cancer.
Overall, this innovative delivery system shows great promise in boosting the therapeutic effects of 5-ALA against skin cancer.
Read More
9
We developed a folic acid-targeted liposome system to improve the delivery of sorafenib, a drug used in treating liver cancer. Through various techniques, we created liposomes loaded with sorafenib and evaluated their effects on liver cancer cells. Our results showed that this targeted system effectively inhibited cancer cell growth and induced apoptosis in vitro. Additionally, in a liver xenograft model, it successfully slowed tumor progression. Overall, our findings suggest that this targeted delivery method could enhance liver cancer therapy while minimizing side effects.
Read More
9
Folate-targeted nanoparticle therapy
We explored the potential of mesoporous silica nanoparticles (MSNs) enhanced with folic acid (FA) to deliver the chemotherapy drug epirubicin (EPI) effectively in breast cancer treatment.
Our research showed that this targeted delivery system significantly inhibited cancer cell growth both in laboratory settings and in mice. Notably, it encouraged cancer cell death through various molecular pathways while avoiding toxicity in other organs.
These findings suggest that folic acid's targeting ability may greatly enhance the effectiveness of anticancer therapies like epirubicin.
Our research showed that this targeted delivery system significantly inhibited cancer cell growth both in laboratory settings and in mice. Notably, it encouraged cancer cell death through various molecular pathways while avoiding toxicity in other organs.
These findings suggest that folic acid's targeting ability may greatly enhance the effectiveness of anticancer therapies like epirubicin.
Read More
9
We explored the use of folic acid-conjugated magnetic nanoparticles for improving cancer treatment. These nanoparticles, loaded with the chemotherapy drug doxorubicin, were designed to target cancer cells that overexpress folate receptors.
The study found that these nanoparticles allow for better drug delivery and increased cytotoxicity against certain cancer cells. They showed effective drug release, especially in acidic environments typical of cancer cells.
Overall, while the nanoparticles enhanced the drug delivery mechanism, the study indicates that the overall benefit from folic acid was primarily in improving drug uptake rather than a transformative impact on treatment outcomes.
The study found that these nanoparticles allow for better drug delivery and increased cytotoxicity against certain cancer cells. They showed effective drug release, especially in acidic environments typical of cancer cells.
Overall, while the nanoparticles enhanced the drug delivery mechanism, the study indicates that the overall benefit from folic acid was primarily in improving drug uptake rather than a transformative impact on treatment outcomes.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 15 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Has anticancer properties
Methylfolate, the active form of folic acid, crosses the blood-brain barrier to promote a healthy nervous system. It supports cardiovascular health by managing homocysteine levels, which are linked to heart disease. Methylfolate aids in the production of essential neurotransmitters and improves mood. It positively affects cognitive functions and has been shown to have anticancer effects against various tumours, including cervical and colorectal cancers.
Read More
6
Essential for growth
21 people found this helpful
Folic acid B9 is vital for the bone marrow, aiding neurotransmitter synthesis to regulate appetite, sleep, and mood while reducing cancer risk. Daily intake before and during the first three months of pregnancy is vital for the child's development and preventing anaemia in pregnant women. It's also beneficial after 40, improving sleep, memory, blood pressure stability, and reducing diabetes risk while enhancing skin and hair health.
Read More
6
Prevent neural issues
1 people found this helpful
Folic acid is crucial during pregnancy planning to prevent neural tube defects. It is beneficial in treating certain types of anaemia and aids in developing the circulatory system while helping to prevent cancer. I take one capsule daily after meals to support these needs.
Read More
7.5
Supports cell integrity
Folate is a vitamin B that helps produce and maintain new cells while preventing DNA changes that can result in cancer.
Read More
7.5
Recommended quality
It aids in cell production and maintaining integrity while preventing DNA changes that may lead to cancer. This good quality folic acid was prescribed by my doctor as a preparation for pregnancy.
Read More
Frequently Asked Questions
9
Has anticancer properties
Methylfolate, the active form of folic acid, crosses the blood-brain barrier to promote a healthy nervous system. It supports cardiovascular health by managing homocysteine levels, which are linked to heart disease. Methylfolate aids in the production of essential neurotransmitters and improves mood. It positively affects cognitive functions and has been shown to have anticancer effects against various tumours, including cervical and colorectal cancers.
6
Prevent neural issues
1 people found this helpful
Folic acid is crucial during pregnancy planning to prevent neural tube defects. It is beneficial in treating certain types of anaemia and aids in developing the circulatory system while helping to prevent cancer. I take one capsule daily after meals to support these needs.
6
Essential for growth
21 people found this helpful
Folic acid B9 is vital for the bone marrow, aiding neurotransmitter synthesis to regulate appetite, sleep, and mood while reducing cancer risk. Daily intake before and during the first three months of pregnancy is vital for the child's development and preventing anaemia in pregnant women. It's also beneficial after 40, improving sleep, memory, blood pressure stability, and reducing diabetes risk while enhancing skin and hair health.
7.5
Supports cell integrity
Folate is a vitamin B that helps produce and maintain new cells while preventing DNA changes that can result in cancer.
6
Improves well-being
Folic acid B9 supports the bone marrow and neurotransmitter synthesis, crucial for appetite, sleep, mood, and may reduce cancer risk. It's necessary to take it daily before and during the first three months of pregnancy to ensure healthy child development and prevent anaemia. Women over 40 should also consider folic acid to enhance sleep, memory, blood pressure regulation, and skin and hair health.
9
We developed a folic acid-targeted liposome system to improve the delivery of sorafenib, a drug used in treating liver cancer. Through various techniques, we created liposomes loaded with sorafenib and evaluated their effects on liver cancer cells. Our results showed that this targeted system effectively inhibited cancer cell growth and induced apoptosis in vitro. Additionally, in a liver xenograft model, it successfully slowed tumor progression. Overall, our findings suggest that this targeted delivery method could enhance liver cancer therapy while minimizing side effects.
9
Folate-targeted nanoparticle therapy
We explored the potential of mesoporous silica nanoparticles (MSNs) enhanced with folic acid (FA) to deliver the chemotherapy drug epirubicin (EPI) effectively in breast cancer treatment.
Our research showed that this targeted delivery system significantly inhibited cancer cell growth both in laboratory settings and in mice. Notably, it encouraged cancer cell death through various molecular pathways while avoiding toxicity in other organs.
These findings suggest that folic acid's targeting ability may greatly enhance the effectiveness of anticancer therapies like epirubicin.
Our research showed that this targeted delivery system significantly inhibited cancer cell growth both in laboratory settings and in mice. Notably, it encouraged cancer cell death through various molecular pathways while avoiding toxicity in other organs.
These findings suggest that folic acid's targeting ability may greatly enhance the effectiveness of anticancer therapies like epirubicin.
9
FLOT regimen shows treatment promise
We aimed to explore the effectiveness of the FLOT chemotherapy regimen, which incorporates folate, in treating locally advanced gastric cancer. Our study focused on patients who received this treatment from 2017 to 2020, assessing their responses to chemotherapy based on a measure called tumor regression grade (TRG).
Our findings indicated that a significant portion of patients responded well to the therapy, with nearly 30% achieving either a complete or moderate response. Notably, we discovered that lymphovascular invasion—when cancer spreads to the lymphatic system—can help predict these responses.
Crucially, patients who showed positive histopathological responses had much better outcomes, boasting impressive two-year disease-free survival and overall survival rates. With only a small number suffering from severe side effects, the FLOT regimen demonstrates a favorable toxicity profile. Although folate is a component of this treatment, its isolated impact is difficult to deduce since it works in combination with several other medications.
Overall, our results highlight the potential of the FLOT regimen in providing effective treatment options for gastric cancer patients, emphasizing improved survival rates for those who respond positively to chemotherapy.
Our findings indicated that a significant portion of patients responded well to the therapy, with nearly 30% achieving either a complete or moderate response. Notably, we discovered that lymphovascular invasion—when cancer spreads to the lymphatic system—can help predict these responses.
Crucially, patients who showed positive histopathological responses had much better outcomes, boasting impressive two-year disease-free survival and overall survival rates. With only a small number suffering from severe side effects, the FLOT regimen demonstrates a favorable toxicity profile. Although folate is a component of this treatment, its isolated impact is difficult to deduce since it works in combination with several other medications.
Overall, our results highlight the potential of the FLOT regimen in providing effective treatment options for gastric cancer patients, emphasizing improved survival rates for those who respond positively to chemotherapy.
References
- Rostami N, Nikzad A, Shaybani S, Noei H, Ghebleh A, et al. Engineering Folic Acid-Modified Nanoparticles to Enhance Letrozole's Anticancer Action. Macromol Biosci. 2025. doi:10.1002/mabi.202400558
- Li Y, Wang Q, Yang N, Yan H, Zhu Y, et al. Novel Folate-phenylfuran P-gp Inhibitor Conjugates for Overcoming Multidrug Resistance in MCF-7/ADR Cell. ChemMedChem. 2025. doi:10.1002/cmdc.202500216
- Goemaere I, Cielo A, Daniele R, Mastrotto F, De Smedt SC, et al. Nanosecond Laser Pulses Facilitating Efficient and Specific Cell Killing with Doxorubicin-Loaded Gold Nanoparticles Targeted to the Folate Receptor. Small Sci. 2025;5:2400234. doi:10.1002/smsc.202400234
- Patki SR, P SS, Manjappa AS, Veerachamy A, Sankaranarayanan M, et al. Identification of Active Phytochemicals to Inhibit Signal Transducer and Activator of Transcription 5A (STAT5A) Dimerization for Prostate Cancer Therapy: An In Silico Approach. Anticancer Agents Med Chem. 2025. doi:10.2174/0118715206367609250329195533
- Liu X, Zhang Y, Zhang P, Ge K, Zhang R, et al. Preparation of targeting nanogels for controlled delivery of 5-aminolevulinic acid triggered by matrix metalloproteinases as photodynamic therapy. Biointerphases. 2025;20. doi:10.1116/6.0004203
- Liu S, Yi D, Ma R, Zhang W. Folic Acid-Targeted Liposome-Based Nanoparticle Loaded with Sorafenib for Liver Cancer Therapy. Int J Nanomedicine. 2025;20:3933. doi:10.2147/IJN.S489777
- Farsani NK, Afshari S, Poor AS, Toutounchi A, Shahbazi Z, et al. pH-responsive mesoporous silica nanoparticles functionalized with folic acid and chitosan for targeted epirubicin delivery: In vitro and in vivo efficacy in breast cancer. Int J Biol Macromol. 2025;309:142558. doi:10.1016/j.ijbiomac.2025.142558
- Dash BS, Lai YC, Chen JP. Folic Acid-Conjugated Magnetic Oleoyl-Chitosan Nanoparticles for Controlled Release of Doxorubicin in Cancer Therapy. Nanomaterials (Basel). 2025;15. doi:10.3390/nano15060415
- Xie F, Liu N, Liu X, Feng X, Yang Z, et al. Insights into folic acid functionalization of self-assembled octenyl succinic anhydride starch micelles towards targeted delivery of selenium nanoparticles. Int J Biol Macromol. 2025;308:142352. doi:10.1016/j.ijbiomac.2025.142352
- Nalawade S, Narwade M, Deshmukh V, Nasir N, Wahab S, et al. Surface-modified nintedanib-loaded solid lipid nanoparticles for effective targeting of non-small cell lung cancer. Colloids Surf B Biointerfaces. 2025;251:114622. doi:10.1016/j.colsurfb.2025.114622
- Serag E, El-Fakharany EM, Hammad SF, El-Khouly ME. Metal-organic framework MIL-101(Fe) functionalized with folic acid as a multifunctional nanocarrier for targeted chemotherapy-photodynamic therapy. Biomater Sci. 2025. doi:10.1039/d4bm01738b
- Ghosh T, Mandal M, Shee M, Das TK, Mandal M, et al. Fabrication of Folic Acid-Derived Carbon Dot-Conjugated Chitosan Nanospheres as Theragnostic Agents for pH-Responsive Anticancer Drug Delivery. ACS Appl Bio Mater. 2025;8:3096. doi:10.1021/acsabm.4c01962
- Kucerova L, Fekiacova A, Udvorkova N, Malcharkova P, Blahova V, et al. Mirvetuximab Soravtansine Induces Potent Cytotoxicity and Bystander Effect in Cisplatin-Resistant Germ Cell Tumor Cells. Cells. 2025;14. doi:10.3390/cells14040287
- Kim J, Kim M, Han H, Kim S, Lahiji SF, et al. Dual-delivery of exosome inhibitor and immune-activating gene via lipid nano-assemblies for tumor immune evasion inhibition. J Control Release. 2025;381:113569. doi:10.1016/j.jconrel.2025.02.065
- Auchynnikava T, Äärelä A, Moisio O, Liljenbäck H, Andriana P, et al. Biological Evaluation of Molecular Spherical Nucleic Acids: Targeting Tumors via a Hybridization-Based Folate Decoration. ACS Omega. 2025;10:6003. doi:10.1021/acsomega.4c10047
- Lotter C, Stierli MA, Puligilla RD, Huwyler J. Dual targeted lipid nanoparticles for enhanced DNA delivery and transfection of breast cancer cells. Eur J Pharm Biopharm. 2025. doi:10.1016/j.ejpb.2025.114674
- Qi P, Chen L, Ma A, Zhang Y, Lin H, et al. Genetically predicted vitamins supplementation and risk of skin cancers: a Mendelian randomization study. Discov Oncol. 2025;16:204. doi:10.1007/s12672-025-01905-9
- Morshedi B, Esfandyari-Manesh M, Atyabi F, Ghahremani MH, Dinarvand R. Local delivery of ibrutinib by folate receptor-mediated targeting PLGA-PEG nanoparticles to glioblastoma multiform: and studies. J Drug Target. 2025. doi:10.1080/1061186X.2025.2468749
- Atci MM, Secmeler S, Sakin A, Arici S, Can O, et al. Perioperative 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) regimen in gastric cancer: Pathological regression grade and its relationship to clinical outcome. Indian J Cancer. 2024;61:714. doi:10.4103/ijc.IJC_1283_20
- Qin J, Ouyang C, Zhuang X. Association between folate and glutamine metabolism and prognosis of kidney cancer. Front Nutr. 2024;11:1506967. doi:10.3389/fnut.2024.1506967
- Konishi K, Fukumoto Y, Minoji T, Muranishi K, Nishigaki T, et al. [A Case of Sigmoid Colon Cancer with Bladder Invasion Successfully Treated with Chemotherapy with mFOLFOX6+Cetuximab]. Gan To Kagaku Ryoho. 2024;51:1797.
- Xie M, Zhao J, Feng X, Gao X, Cheng W, et al. Cell membrane-inspired chitosan nanoparticles for prolonged circulation and tumor-targeted drug delivery. Int J Biol Macromol. 2025;304:140934. doi:10.1016/j.ijbiomac.2025.140934
