Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.9
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B6 (as Pyridoxal-5-Phosphate)
1.5 mg
88%
Folate (400 mcg as (6S)-5-MTHF [from (6S)-5-Methyltetrahydrofolate Glucosamine Salt])
680 mcg DFE‡
170%
Vitamin B12 (as Methylcobalamin)
1,000 mcg
41,667%
Top Medical Research Studies
9
We explored the role of the vitamin B6 pathway in glioblastoma, a particularly aggressive form of brain cancer. Through a detailed analysis involving various cell cultures, we noted significant changes in vitamin B6-related metabolites when comparing 3D spheroid cultures to traditional 2D monolayers.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
9
We examined how vitamin B6, specifically its active form pyridoxal 5'-phosphate (PLP), influences cancer development using Drosophila as a model. The study revealed that deficiency in PLP, triggered by specific compounds like 4-deoxypyridoxine (4DP), led to the transformation of benign tumors driven by oncogenic Ras into more aggressive cancer forms.
Interestingly, supplementing with PLP was shown to slow down this tumor progression, suggesting that adequate levels of vitamin B6 could play a protective role. Our research further demonstrated that low PLP levels contributed to genetic instability, which is a common feature in cancer cells.
By focusing on the relationship between PLP deficiency and genome instability, we uncovered that this deficiency promotes the formation of reactive oxygen species (ROS) and negatively affects DNA replication and repair processes. Remarkably, we found that providing PLP or ascorbic acid, along with necessary components for DNA synthesis, could alleviate both genetic abnormalities and tumor development in the studied larvae.
Overall, our findings offer valuable insights into the significance of vitamin B6 in cancer biology and underscore its potential as a dietary consideration in cancer prevention and treatment strategies.
Interestingly, supplementing with PLP was shown to slow down this tumor progression, suggesting that adequate levels of vitamin B6 could play a protective role. Our research further demonstrated that low PLP levels contributed to genetic instability, which is a common feature in cancer cells.
By focusing on the relationship between PLP deficiency and genome instability, we uncovered that this deficiency promotes the formation of reactive oxygen species (ROS) and negatively affects DNA replication and repair processes. Remarkably, we found that providing PLP or ascorbic acid, along with necessary components for DNA synthesis, could alleviate both genetic abnormalities and tumor development in the studied larvae.
Overall, our findings offer valuable insights into the significance of vitamin B6 in cancer biology and underscore its potential as a dietary consideration in cancer prevention and treatment strategies.
9
We explored innovative ways to improve cancer treatment by using folate-targeted nanoparticles. The study focused on the development of chitosan nanoparticles that mimic cell membranes, enhancing their ability to evade the immune system and prolong circulation in the body. By integrating folate, a nutrient known to target cancer cells, we hoped to increase the effectiveness of drug delivery directly to tumors.
Our findings revealed that these folate-targeted nanoparticles showed a remarkable capacity to be absorbed by breast cancer cells, specifically increasing uptake efficiency by five to six times compared to nanoparticles without folate. This was a significant boost, showcasing the potential of using folate as a guiding factor for cancer treatment.
Furthermore, the study demonstrated that these nanoparticles remained in the bloodstream for much longer, with their half-life extended from roughly 2.7 hours to nearly 13 hours. This means they can circulate longer and potentially reach tumors more effectively.
Ultimately, our research aims to pave the way for more efficient cancer therapies, highlighting how leveraging folate in nanoparticle design may provide a promising strategy in the fight against cancer.
Our findings revealed that these folate-targeted nanoparticles showed a remarkable capacity to be absorbed by breast cancer cells, specifically increasing uptake efficiency by five to six times compared to nanoparticles without folate. This was a significant boost, showcasing the potential of using folate as a guiding factor for cancer treatment.
Furthermore, the study demonstrated that these nanoparticles remained in the bloodstream for much longer, with their half-life extended from roughly 2.7 hours to nearly 13 hours. This means they can circulate longer and potentially reach tumors more effectively.
Ultimately, our research aims to pave the way for more efficient cancer therapies, highlighting how leveraging folate in nanoparticle design may provide a promising strategy in the fight against cancer.
Most Useful Reviews
8
Essential for pregnancy
Excellent! Methylfolate ((6S)-5-methyltetrahydrofolate) is a highly effective active form of folic acid. Quatrefolic® is a fourth-generation production technology. 
Folic acid deficiency can cause brain dysfunction, colon cancer, and heart disease! Vitamin C during pregnancy is vital for both mother and child. Sufficient folate in a pregnant woman's diet can reduce the risk of developmental defects in the brain and spinal cord. Additionally, Vitamin C is crucial for all cell growth processes, including supporting immunity and heart function.
Folic acid deficiency can cause brain dysfunction, colon cancer, and heart disease! Vitamin C during pregnancy is vital for both mother and child. Sufficient folate in a pregnant woman's diet can reduce the risk of developmental defects in the brain and spinal cord. Additionally, Vitamin C is crucial for all cell growth processes, including supporting immunity and heart function.8
Reduces cancer risk
Vegan Methyl B-12 Methyl Folate comes in new packaging. It is a nutritional supplement that assists metabolism and lowers the risk of cancer and macular degeneration. I appreciate it even more as it is gluten-free and vegan.
7
Prevents cancer effectively
Excellent! This complex of vitamin B12, seldom included in B vitamin complexes, and folic acid in the form of folate (better absorbed) is exceptional for preventing cancer, Alzheimer's, and other conditions. I particularly recommend it for individuals with folate cycle disorders.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.9
- All Researches
9.5
We studied how high-dose pyridoxine, also known as vitamin B6, influences the effectiveness of chemotherapy drugs like 5-fluorouracil (FUra) and folinic acid (FA) in patients with advanced-stage cancers. Our group of 50 patients included individuals with digestive tract and breast cancers, all characterized by poor prognoses.
During the treatment, patients received standard chemotherapy regimens along with daily infusions of vitamin B6, ranging from 1000 to 3000 mg. Remarkably, a large majority of the patients—94%—responded positively to the combination of these treatments. In fact, over a third experienced complete remission, and those with substantial tumor shrinkage enjoyed extended event-free survival rates.
Despite the complexity of combining therapies, we found that vitamin B6 appears to enhance the overall effectiveness of chemotherapy without introducing unexpected side effects. This exciting finding suggests that vitamin B6 could be a valuable addition in advanced cancer treatment, but we note that more research is needed to understand its role fully in these comprehensive regimens.
During the treatment, patients received standard chemotherapy regimens along with daily infusions of vitamin B6, ranging from 1000 to 3000 mg. Remarkably, a large majority of the patients—94%—responded positively to the combination of these treatments. In fact, over a third experienced complete remission, and those with substantial tumor shrinkage enjoyed extended event-free survival rates.
Despite the complexity of combining therapies, we found that vitamin B6 appears to enhance the overall effectiveness of chemotherapy without introducing unexpected side effects. This exciting finding suggests that vitamin B6 could be a valuable addition in advanced cancer treatment, but we note that more research is needed to understand its role fully in these comprehensive regimens.
9
We explored the role of the vitamin B6 pathway in glioblastoma, a particularly aggressive form of brain cancer. Through a detailed analysis involving various cell cultures, we noted significant changes in vitamin B6-related metabolites when comparing 3D spheroid cultures to traditional 2D monolayers.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
9
We examined how vitamin B6, specifically its active form pyridoxal 5'-phosphate (PLP), influences cancer development using Drosophila as a model. The study revealed that deficiency in PLP, triggered by specific compounds like 4-deoxypyridoxine (4DP), led to the transformation of benign tumors driven by oncogenic Ras into more aggressive cancer forms.
Interestingly, supplementing with PLP was shown to slow down this tumor progression, suggesting that adequate levels of vitamin B6 could play a protective role. Our research further demonstrated that low PLP levels contributed to genetic instability, which is a common feature in cancer cells.
By focusing on the relationship between PLP deficiency and genome instability, we uncovered that this deficiency promotes the formation of reactive oxygen species (ROS) and negatively affects DNA replication and repair processes. Remarkably, we found that providing PLP or ascorbic acid, along with necessary components for DNA synthesis, could alleviate both genetic abnormalities and tumor development in the studied larvae.
Overall, our findings offer valuable insights into the significance of vitamin B6 in cancer biology and underscore its potential as a dietary consideration in cancer prevention and treatment strategies.
Interestingly, supplementing with PLP was shown to slow down this tumor progression, suggesting that adequate levels of vitamin B6 could play a protective role. Our research further demonstrated that low PLP levels contributed to genetic instability, which is a common feature in cancer cells.
By focusing on the relationship between PLP deficiency and genome instability, we uncovered that this deficiency promotes the formation of reactive oxygen species (ROS) and negatively affects DNA replication and repair processes. Remarkably, we found that providing PLP or ascorbic acid, along with necessary components for DNA synthesis, could alleviate both genetic abnormalities and tumor development in the studied larvae.
Overall, our findings offer valuable insights into the significance of vitamin B6 in cancer biology and underscore its potential as a dietary consideration in cancer prevention and treatment strategies.
9
We explored how the folate receptor alpha (FRα) can be a promising target in treating resistant germ cell tumors (GCTs), which often have poor outcomes due to limited therapeutic options. Our research centered on mirvetuximab soravtansine (MIRV), an antibody-drug conjugate that specifically targets FRα, which is frequently overexpressed in many cancer types, including GCTs.
Through our experiments, we observed that FRα levels were significantly higher in several GCT cell lines as compared to normal tissue. When we treated cisplatin-resistant GCT cells with MIRV, we found it not only triggered cell death but also had a strong effect on unintended bystander cells in direct coculture experiments. This suggests that the treatment may extend its reach beyond just the targeted cancer cells.
Additionally, we confirmed through immunohistochemistry that FRα protein expression is notably elevated in GCT patients after chemotherapy, especially in those with unfavorable prognoses. Our findings emphasize the need for further exploration of FRα-targeting therapies as a potential treatment option for GCTs, particularly those that do not respond well to current therapies. MIRV shows significant antitumor effects and encourages further studies into its use in battling treatment-resistant GCTs.
Through our experiments, we observed that FRα levels were significantly higher in several GCT cell lines as compared to normal tissue. When we treated cisplatin-resistant GCT cells with MIRV, we found it not only triggered cell death but also had a strong effect on unintended bystander cells in direct coculture experiments. This suggests that the treatment may extend its reach beyond just the targeted cancer cells.
Additionally, we confirmed through immunohistochemistry that FRα protein expression is notably elevated in GCT patients after chemotherapy, especially in those with unfavorable prognoses. Our findings emphasize the need for further exploration of FRα-targeting therapies as a potential treatment option for GCTs, particularly those that do not respond well to current therapies. MIRV shows significant antitumor effects and encourages further studies into its use in battling treatment-resistant GCTs.
9
We set out to explore how folate can improve treatment strategies for breast cancer, particularly in the HER2-positive subtype. To do this, we designed lipid nanoparticles (LNPs) that could deliver DNA targeted specifically at breast cancer cells. The exciting part was that we used a combination of trastuzumab, a monoclonal antibody that targets HER2, and folate to enhance how effectively these nanoparticles reached the cancer cells.
In our experiments, we created LNPs that captured a DNA plasmid coding for a fluorescent protein. This allowed us to track the effectiveness of our dual-targeting strategy in different breast cancer cell lines. The results were compelling; we found that pairing trastuzumab with folate significantly increased cellular uptake and expression of the delivered DNA when compared to using trastuzumab alone. This indicates that folate plays a crucial role in enhancing the effectiveness of targeted treatments.
Additionally, we conducted tests using zebrafish to confirm that our dual-targeted nanoparticles demonstrated better targeting and transfection under realistic biological conditions. Overall, our findings suggest that this dual-targeting method may provide a more effective approach to delivering therapeutic DNA to HER2-positive breast cancer cells, showcasing the potential for incorporating folate in future cancer treatment strategies.
In our experiments, we created LNPs that captured a DNA plasmid coding for a fluorescent protein. This allowed us to track the effectiveness of our dual-targeting strategy in different breast cancer cell lines. The results were compelling; we found that pairing trastuzumab with folate significantly increased cellular uptake and expression of the delivered DNA when compared to using trastuzumab alone. This indicates that folate plays a crucial role in enhancing the effectiveness of targeted treatments.
Additionally, we conducted tests using zebrafish to confirm that our dual-targeted nanoparticles demonstrated better targeting and transfection under realistic biological conditions. Overall, our findings suggest that this dual-targeting method may provide a more effective approach to delivering therapeutic DNA to HER2-positive breast cancer cells, showcasing the potential for incorporating folate in future cancer treatment strategies.
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
8
Essential for pregnancy
Excellent! Methylfolate ((6S)-5-methyltetrahydrofolate) is a highly effective active form of folic acid. Quatrefolic® is a fourth-generation production technology. Folic acid deficiency can cause brain dysfunction, colon cancer, and heart disease! Vitamin C during pregnancy is vital for both mother and child. Sufficient folate in a pregnant woman's diet can reduce the risk of developmental defects in the brain and spinal cord. Additionally, Vitamin C is crucial for all cell growth processes, including supporting immunity and heart function.
Folic acid deficiency can cause brain dysfunction, colon cancer, and heart disease! Vitamin C during pregnancy is vital for both mother and child. Sufficient folate in a pregnant woman's diet can reduce the risk of developmental defects in the brain and spinal cord. Additionally, Vitamin C is crucial for all cell growth processes, including supporting immunity and heart function.8
Reduces cancer risk
Vegan Methyl B-12 Methyl Folate comes in new packaging. It is a nutritional supplement that assists metabolism and lowers the risk of cancer and macular degeneration. I appreciate it even more as it is gluten-free and vegan.
7
Prevents cancer effectively
Excellent! This complex of vitamin B12, seldom included in B vitamin complexes, and folic acid in the form of folate (better absorbed) is exceptional for preventing cancer, Alzheimer's, and other conditions. I particularly recommend it for individuals with folate cycle disorders.
Frequently Asked Questions
8
Essential for pregnancy
Excellent! Methylfolate ((6S)-5-methyltetrahydrofolate) is a highly effective active form of folic acid. Quatrefolic® is a fourth-generation production technology. Folic acid deficiency can cause brain dysfunction, colon cancer, and heart disease! Vitamin C during pregnancy is vital for both mother and child. Sufficient folate in a pregnant woman's diet can reduce the risk of developmental defects in the brain and spinal cord. Additionally, Vitamin C is crucial for all cell growth processes, including supporting immunity and heart function.
Folic acid deficiency can cause brain dysfunction, colon cancer, and heart disease! Vitamin C during pregnancy is vital for both mother and child. Sufficient folate in a pregnant woman's diet can reduce the risk of developmental defects in the brain and spinal cord. Additionally, Vitamin C is crucial for all cell growth processes, including supporting immunity and heart function.7
Prevents cancer effectively
Excellent! This complex of vitamin B12, seldom included in B vitamin complexes, and folic acid in the form of folate (better absorbed) is exceptional for preventing cancer, Alzheimer's, and other conditions. I particularly recommend it for individuals with folate cycle disorders.
8
Reduces cancer risk
Vegan Methyl B-12 Methyl Folate comes in new packaging. It is a nutritional supplement that assists metabolism and lowers the risk of cancer and macular degeneration. I appreciate it even more as it is gluten-free and vegan.
8
We explored the relationship between serum levels of vitamin B6, specifically pyridoxal 5'-phosphate (PLP), and survival rates in colorectal cancer patients. The study involved 1,286 colorectal cancer patients from the Guangdong Colorectal Cancer Cohort, tracked for their overall and cancer-specific mortality until December 2023.
Our findings revealed that higher levels of PLP were linked to better overall survival and colorectal cancer-specific survival. In contrast, the pyridoxic acid ratio (PAr) did not show a significant association with survival outcomes. We observed that PLP levels correlated positively with longevity in patients, as evidenced by improved survival rates. Moreover, the impact of vitamin B6 varied based on alcohol consumption among patients.
While these results suggest that maintaining adequate vitamin B6 levels may benefit those with colorectal cancer, it is essential to note that the correlation does not establish a definitive cause-and-effect relationship. Thus, while vitamin B6 shows promising signs in enhancing survival, further research is needed to confirm its efficacy.
Our findings revealed that higher levels of PLP were linked to better overall survival and colorectal cancer-specific survival. In contrast, the pyridoxic acid ratio (PAr) did not show a significant association with survival outcomes. We observed that PLP levels correlated positively with longevity in patients, as evidenced by improved survival rates. Moreover, the impact of vitamin B6 varied based on alcohol consumption among patients.
While these results suggest that maintaining adequate vitamin B6 levels may benefit those with colorectal cancer, it is essential to note that the correlation does not establish a definitive cause-and-effect relationship. Thus, while vitamin B6 shows promising signs in enhancing survival, further research is needed to confirm its efficacy.
7
Vitamin B6 may reduce CIPN severity
In our research, we delved into how vitamin B6 might affect chronic chemotherapy-induced peripheral neuropathy (CIPN) among patients with non-metastatic colorectal cancer undergoing treatment with oxaliplatin. This type of neuropathy can persist long after chemotherapy has finished, often impacting patients' quality of life. We aimed to uncover any links between vitamin B6 levels in the blood and the severity and occurrence of chronic CIPN among these individuals.
We observed a cohort of 242 patients and collected their blood samples at three key points: before treatment, during treatment, and a year after diagnosis. We measured specific markers of vitamin B6, such as pyridoxal 5'-phosphate (PLP), to gauge their vitamin B6 status. Our analyses took into account various factors, including age, sex, and lifestyle choices, ensuring a comprehensive understanding of the situation.
Interestingly, our findings revealed that while having normal levels of PLP was important, higher vitamin B6 levels during chemotherapy were associated with a lower occurrence and severity of chronic CIPN. This suggests that maintaining adequate vitamin B6 levels could potentially benefit patients experiencing this uncomfortable side effect. However, further research is needed to establish a clear cause-and-effect relationship and determine the optimal levels of vitamin B6 for managing side effects during cancer treatment.
We observed a cohort of 242 patients and collected their blood samples at three key points: before treatment, during treatment, and a year after diagnosis. We measured specific markers of vitamin B6, such as pyridoxal 5'-phosphate (PLP), to gauge their vitamin B6 status. Our analyses took into account various factors, including age, sex, and lifestyle choices, ensuring a comprehensive understanding of the situation.
Interestingly, our findings revealed that while having normal levels of PLP was important, higher vitamin B6 levels during chemotherapy were associated with a lower occurrence and severity of chronic CIPN. This suggests that maintaining adequate vitamin B6 levels could potentially benefit patients experiencing this uncomfortable side effect. However, further research is needed to establish a clear cause-and-effect relationship and determine the optimal levels of vitamin B6 for managing side effects during cancer treatment.
9
We explored the role of the vitamin B6 pathway in glioblastoma, a particularly aggressive form of brain cancer. Through a detailed analysis involving various cell cultures, we noted significant changes in vitamin B6-related metabolites when comparing 3D spheroid cultures to traditional 2D monolayers.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
This discovery led us to investigate further the implications of these findings for cancer cell survival. We found that using hydralazine, a compound that effectively reduces vitamin B6 levels, triggered cell death in 3D GBM spheroid cultures.
Our results suggest that targeting the vitamin B6 pathway could offer a new avenue for developing treatments for this challenging cancer. This innovative approach highlights the necessity of understanding metabolic processes within tumor environments for creating effective therapies.
7
Vitamin B6 may boost immunotherapy
We conducted an in-depth analysis of how vitamin B6 might influence cancer treatment, particularly for advanced gastric cancer. Our research involved looking at tissue samples from patients to assess the role of certain immune structures known as tertiary lymphoid structures (TLSs) before and after they underwent immunotherapy.
By employing various scientific tools like spatial and single-cell transcriptional analyses, we were able to highlight the importance of specific immune cells, notably the CXCL13 CD160 CD8 T cells, in the formation of these crucial structures. We found that the presence and activity of these immune cells could indicate how well patients might respond to treatment.
Interestingly, our results suggest that vitamin B6 could play a role in enhancing the function of these T cells, possibly by preventing the breakdown of a protein called HIF-1α, which is important for immune cell activity. This means that vitamin B6 supplementation, or targeting certain related mechanisms, may significantly improve the effectiveness of immunotherapies in treating gastric cancer.
While the findings are promising, it's essential to note that this research points to a potential enhancement in response rather than outright cures. It's a step toward making cancer treatments more effective, highlighting the interplay between nutrition and cancer therapy.
By employing various scientific tools like spatial and single-cell transcriptional analyses, we were able to highlight the importance of specific immune cells, notably the CXCL13 CD160 CD8 T cells, in the formation of these crucial structures. We found that the presence and activity of these immune cells could indicate how well patients might respond to treatment.
Interestingly, our results suggest that vitamin B6 could play a role in enhancing the function of these T cells, possibly by preventing the breakdown of a protein called HIF-1α, which is important for immune cell activity. This means that vitamin B6 supplementation, or targeting certain related mechanisms, may significantly improve the effectiveness of immunotherapies in treating gastric cancer.
While the findings are promising, it's essential to note that this research points to a potential enhancement in response rather than outright cures. It's a step toward making cancer treatments more effective, highlighting the interplay between nutrition and cancer therapy.
5
In our investigation of vitamin B6's potential impact on cancer risk, we examined the relationship between various B-vitamin levels and the incidence of esophageal squamous cell carcinoma (ESCC) and gastric cancer (GC) among participants in the Golestan Cohort Study. This study included matched case-control pairs, allowing us to assess the differences between those who developed cancer and those who did not.
Despite our expectations, we discovered that none of the measured B-vitamin levels, including vitamin B6, showed a significant association with the risk of developing these cancers. However, we did notice that elevated levels of a specific biomarker called methylmalonic acid (MMA) were marginally linked to ESCC and had a stronger association with gastric cancer.
Interestingly, a related measure for vitamin B6 status showed a higher risk of GC among participants with elevated levels. Additionally, we noted that higher levels of total homocysteine, which can indicate overall issues with one-carbon metabolism, were associated with an increased risk of both ESCC and GC.
Ultimately, while we did not find a direct benefit of vitamin B6 treatment on cancer risk, our findings suggest that improvements in B12 and B6 status could be linked with lower cancer risks in this population, particularly given their prevalent low plasma B-vitamin levels.
Despite our expectations, we discovered that none of the measured B-vitamin levels, including vitamin B6, showed a significant association with the risk of developing these cancers. However, we did notice that elevated levels of a specific biomarker called methylmalonic acid (MMA) were marginally linked to ESCC and had a stronger association with gastric cancer.
Interestingly, a related measure for vitamin B6 status showed a higher risk of GC among participants with elevated levels. Additionally, we noted that higher levels of total homocysteine, which can indicate overall issues with one-carbon metabolism, were associated with an increased risk of both ESCC and GC.
Ultimately, while we did not find a direct benefit of vitamin B6 treatment on cancer risk, our findings suggest that improvements in B12 and B6 status could be linked with lower cancer risks in this population, particularly given their prevalent low plasma B-vitamin levels.
8
We investigated a unique vitamin B6-based ligand and its metal complexes to understand their effects on cancer, particularly focusing on liver cancer cells (HepG2). The researchers designed their study by synthesizing a ligand from pyridoxal hydrochloride, the active form of vitamin B6, and then creating metal complexes with zinc, copper, and cobalt. These complexes were meticulously characterized using techniques like spectroscopy to confirm their structure and properties.
Our findings revealed that these metal complexes had the ability to interact with DNA and bovine serum albumin (BSA), suggesting potential pathways for therapeutic action. Notably, one complex showed strong binding to BSA, indicating it may effectively target cancerous tissues. We observed promising results for the copper complex, which displayed significant cancer cell toxicity, inducing cell cycle arrest at the G2/M phase and leading to apoptosis, the programmed cell death essential for eliminating cancer cells.
While we recognized the potential of vitamin B6 derivatives in cancer therapy through these metal complexes, it’s essential to note that the overall direct impact of vitamin B6 alone on cancer treatment remains complex and requires further investigation. Nonetheless, these insights open new avenues for exploring vitamin B6 in conjunction with metal complexes as cancer-fighting agents.
Our findings revealed that these metal complexes had the ability to interact with DNA and bovine serum albumin (BSA), suggesting potential pathways for therapeutic action. Notably, one complex showed strong binding to BSA, indicating it may effectively target cancerous tissues. We observed promising results for the copper complex, which displayed significant cancer cell toxicity, inducing cell cycle arrest at the G2/M phase and leading to apoptosis, the programmed cell death essential for eliminating cancer cells.
While we recognized the potential of vitamin B6 derivatives in cancer therapy through these metal complexes, it’s essential to note that the overall direct impact of vitamin B6 alone on cancer treatment remains complex and requires further investigation. Nonetheless, these insights open new avenues for exploring vitamin B6 in conjunction with metal complexes as cancer-fighting agents.
References
- Renting L, Zwart NRK, Ueland PM, McCann A, Ulvik A, et al. Vitamin B6 status and chronic chemotherapy-induced peripheral neuropathy: a prospective cohort study among patients with non-metastatic colorectal cancer receiving oxaliplatin-based chemotherapy. BMJ Oncol. 2024;3:e000462. doi:10.1136/bmjonc-2024-000462
- Li X, Xu L, Ou QJ, Xu H, Chen YY, et al. Serum Pyridoxal 5'-Phosphate and Pyridoxic Acid Ratio Index with Prognosis of Colorectal Cancer: A Prospective Cohort Study. Nutrients. 2024;16. doi:10.3390/nu16213685
- Moosa NY, Azeem SA, Lodge JK, Cheung W, Ahmed SU. Vitamin B6 Pathway Maintains Glioblastoma Cell Survival in 3D Spheroid Cultures. Int J Mol Sci. 2024;25. doi:10.3390/ijms251910428
- Alroba AAN, Aazam ES, Zaki M. Metal complexes containing vitamin B6-based scaffold as potential DNA/BSA-binding agents inducing apoptosis in hepatocarcinoma (HepG2) cells. Mol Divers. 2024. doi:10.1007/s11030-024-10986-7
- Wang J, Liang Y, Xue A, Xiao J, Zhao X, et al. Intratumoral CXCL13 CD160 CD8 T cells promote the formation of tertiary lymphoid structures to enhance the efficacy of immunotherapy in advanced gastric cancer. J Immunother Cancer. 2024;12. doi:10.1136/jitc-2024-009603
- Inoue-Choi M, Freedman ND, Etemadi A, Hashemian M, Brennan P, et al. One-carbon metabolism biomarkers and upper gastrointestinal cancer in the Golestan Cohort Study. Int J Cancer. 2024;155:1944. doi:10.1002/ijc.35115
- Pilesi E, Tesoriere G, Ferriero A, Mascolo E, Liguori F, et al. Vitamin B6 deficiency cooperates with oncogenic Ras to induce malignant tumors in Drosophila. Cell Death Dis. 2024;15:388. doi:10.1038/s41419-024-06787-3
- Machover D, Almohamad W, Castagné V, Desterke C, Gomez L, et al. Treatment of patients with carcinomas in advanced stages with 5-fluorouracil, folinic acid and pyridoxine in tandem. Sci Rep. 2024;14:12054. doi:10.1038/s41598-024-62860-z
- Kucerova L, Fekiacova A, Udvorkova N, Malcharkova P, Blahova V, et al. Mirvetuximab Soravtansine Induces Potent Cytotoxicity and Bystander Effect in Cisplatin-Resistant Germ Cell Tumor Cells. Cells. 2025;14. doi:10.3390/cells14040287
- Kim J, Kim M, Han H, Kim S, Lahiji SF, et al. Dual-delivery of exosome inhibitor and immune-activating gene via lipid nano-assemblies for tumor immune evasion inhibition. J Control Release. 2025;381:113569. doi:10.1016/j.jconrel.2025.02.065
- Auchynnikava T, Äärelä A, Moisio O, Liljenbäck H, Andriana P, et al. Biological Evaluation of Molecular Spherical Nucleic Acids: Targeting Tumors via a Hybridization-Based Folate Decoration. ACS Omega. 2025;10:6003. doi:10.1021/acsomega.4c10047
- Lotter C, Stierli MA, Puligilla RD, Huwyler J. Dual targeted lipid nanoparticles for enhanced DNA delivery and transfection of breast cancer cells. Eur J Pharm Biopharm. 2025. doi:10.1016/j.ejpb.2025.114674
- Qi P, Chen L, Ma A, Zhang Y, Lin H, et al. Genetically predicted vitamins supplementation and risk of skin cancers: a Mendelian randomization study. Discov Oncol. 2025;16:204. doi:10.1007/s12672-025-01905-9
- Morshedi B, Esfandyari-Manesh M, Atyabi F, Ghahremani MH, Dinarvand R. Local delivery of ibrutinib by folate receptor-mediated targeting PLGA-PEG nanoparticles to glioblastoma multiform: and studies. J Drug Target. 2025. doi:10.1080/1061186X.2025.2468749
- Atci MM, Secmeler S, Sakin A, Arici S, Can O, et al. Perioperative 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) regimen in gastric cancer: Pathological regression grade and its relationship to clinical outcome. Indian J Cancer. 2024;61:714. doi:10.4103/ijc.IJC_1283_20
- Qin J, Ouyang C, Zhuang X. Association between folate and glutamine metabolism and prognosis of kidney cancer. Front Nutr. 2024;11:1506967. doi:10.3389/fnut.2024.1506967
- Konishi K, Fukumoto Y, Minoji T, Muranishi K, Nishigaki T, et al. [A Case of Sigmoid Colon Cancer with Bladder Invasion Successfully Treated with Chemotherapy with mFOLFOX6+Cetuximab]. Gan To Kagaku Ryoho. 2024;51:1797.
- Xie M, Zhao J, Feng X, Gao X, Cheng W, et al. Cell membrane-inspired chitosan nanoparticles for prolonged circulation and tumor-targeted drug delivery. Int J Biol Macromol. 2025;304:140934. doi:10.1016/j.ijbiomac.2025.140934
- El-Najjar SE, Naser IA, Al-Wahidi KM. Is Functional Vitamin B12 Deficiency a Risk Factor for the Development of Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients?. Asian Pac J Cancer Prev. 2025;26:375. doi:10.31557/APJCP.2025.26.2.375
- Zhang Y, Xia H, Yang S, Yu W, Liu M, et al. Dietary factors and the risk of gastric and colorectal cancers: A Mendelian randomization study. Medicine (Baltimore). 2025;104:e41610. doi:10.1097/MD.0000000000041610
- Yang J, Liu Y, Yao H, Sun M, Tong Y, et al. Effect of Dendrobium Officinale on Radioactive Oral Mucositis of Nasopharyngeal Carcinoma and Changes of Oral Microecology. Integr Cancer Ther. 2025;24:15347354251313524. doi:10.1177/15347354251313524
- Munteanu C, Mârza SM, Papuc I. The immunomodulatory effects of vitamins in cancer. Front Immunol. 2024;15:1464329. doi:10.3389/fimmu.2024.1464329
- Tinelli A, Gustapane S, Licchelli M, Coluccia AC, Panese G, et al. Treatment with Epigallocatechin Gallate, Folic Acid, Vitamin B12, and Hyaluronic Acid Decreases HPV Positivity in Women Attending Regional Screening in Puglia. Microorganisms. 2024;12. doi:10.3390/microorganisms12091897
- Rong YY, Liu PC, Huang XB, Chen GA. Circulating levels of vitamins and risk of lymphoma: insights from a two-sample Mendelian randomization. Expert Rev Hematol. 2024;17:833. doi:10.1080/17474086.2024.2410009
