We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
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4
Effectiveness of magnesium on constipation
Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study.
We explored how changing the frequency of magnesium oxide (MgO) doses influences its effectiveness in relieving constipation. In this study, we looked at 11 patients who had been regularly using MgO to manage their bowel movements and decided to reduce their daily dose frequency over two weeks.
Initially, patients were taking magnesium three times a day, but we reduced this to either two or one dose per day while keeping the total amount the same. We found that the average number of bowel movements dropped from 7.6 to 6.6 in this period. However, this change wasn't statistically significant, indicating that it may not be clinically meaningful.
Additionally, we measured stool consistency using the Bristol Stool Form Scale and noted no significant difference before and after the dosage adjustment. Our findings suggest that reducing the number of doses does not impact the laxative effect of magnesium oxide. This implies that patients can comfortably manage their magnesium intake without sacrificing effectiveness.
Read More
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
Read More
Most Useful Reviews
7.5
Improves regularity
1 people found this helpful
I use it for better sleep and to keep me “regular.” It truly has enhanced my sleep quality and enabled me to have a more consistent bowel movement. Previously, I could go days without a visit to the loo, but now my constipation is manageable. I must be cautious, as it can occasionally be a bit too effective. I don’t take it every night.
Read More
10
Effective remedy
Constipation is resolved effectively if you follow the recommended use.
Read More
9
Relieves constipation
I regularly take magnesium, as it is essential for relieving constipation!
We explored the relationship between magnesium supplementation, defecation, and cognitive performance in elite triathletes. In a carefully designed crossover trial, participants undertook cognitive tests after taking magnesium oxide and after defecation. This study highlighted an interesting potential connection between the state of our digestive system and cognitive abilities.
We found that after magnesium-induced defecation, participants completed cognitive tasks more quickly compared to when they had not defecated. Specifically, the average completion time for the cognitive test dropped significantly after defecation when magnesium was involved. While this suggests that magnesium can aid in relieving constipation, its role in improving overall cognitive function during athletics is also noteworthy.
Although we observed an increase in cognitive performance following magnesium supplementation, it’s important to note that no significant changes in blood flow or oxygen levels were detected in the brain during the test. Instead, we noted decreased oxygen levels in the digestive region, hinting at an increased demand for energy there.
Overall, our findings suggest a potential new avenue for enhancing cognitive function in athletes through magnesium to improve constipation. However, the direct effects of magnesium solely on constipation require further investigation.
Read More
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
Read More
9
Magnesium aids cancer patient care
Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial.
We conducted a randomized, double-blind trial to assess how magnesium-L-threonate, a new compound, might help relieve constipation while enhancing the pain relief effects of opioids in patients with advanced cancer. During the study, patients receiving this treatment were compared with those taking a placebo, allowing us to clearly see the differences in outcomes.
As the trial progressed, we noticed significant improvements in the group taking magnesium-L-threonate. Notably, this treatment not only helped in managing pain more effectively but also significantly alleviated opioid-induced constipation—a common side effect of opioid use. The data indicated that patients on magnesium-L-threonate required lower doses of opioids for pain management while enjoying better gastrointestinal comfort.
Overall, our findings suggest that magnesium-L-threonate is a promising option in the palliative care landscape for cancer patients, addressing both pain relief and constipation, which can greatly enhance their quality of life.
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9
Magnesium may alleviate constipation
Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial.
We examined the effectiveness of oral magnesium sulfate in treating chronic constipation for children with spastic cerebral palsy. In our study, 100 children received either magnesium sulfate or a placebo for one month.
After this period, we noticed significant improvements in bowel movement frequency and stool consistency in the magnesium group, while the placebo group showed minimal change.
This treatment not only alleviated constipation but also reduced the distress of painful bowel movements for both children and their mothers.
Read More
9
Effective treatment for chronic constipation
Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial.
We explored the effectiveness of magnesium oxide (MgO) as a treatment for chronic constipation using a robust randomized, placebo-controlled trial. Over 28 days, participants received MgO, senna, or a placebo.
Both MgO and senna significantly improved bowel movement frequency and quality of life compared to placebo. About 68.3% of those using MgO reported symptom improvement, showcasing its potential as an effective osmotic agent alongside a stimulant laxative.
Importantly, there were no severe treatment-related side effects reported during the trial.
I use it for better sleep and to keep me “regular.” It truly has enhanced my sleep quality and enabled me to have a more consistent bowel movement. Previously, I could go days without a visit to the loo, but now my constipation is manageable. I must be cautious, as it can occasionally be a bit too effective. I don’t take it every night.
Read More
10
Effective remedy
Constipation is resolved effectively if you follow the recommended use.
Read More
9
Relieves constipation
I regularly take magnesium, as it is essential for relieving constipation!
Read More
9
Natural bowel movements
It’s effective for my constipation, which arises when I consume flour. Taking a tablet daily ensures natural bowel movements. If I skip it, I struggle. It's more affordable than over-the-counter and prescription medications while providing the same benefits, so I will continue using it.
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9
Improved sleep
Best! I can sleep well. It's good to eat, but having it after dinner aids sleep and has helped resolve my constipation.
Constipation is a common condition characterized by infrequent bowel movements or difficulty passing stools. It is typically defined as having fewer than three bowel movements per week, leading to hard, dry stools that are painful or difficult to expel. This condition can be caused by a variety of factors, including diet, dehydration, lack of physical activity, and certain medications. Stress and lifestyle changes can also contribute, making it essential for individuals to identify the root causes of their constipation for effective relief.
To alleviate constipation, it’s recommended to increase fiber intake by consuming more fruits, vegetables, whole grains, and legumes, as well as ensuring adequate hydration throughout the day. Regular exercise can also promote healthy bowel function. If over-the-counter solutions such as fiber supplements or laxatives aren't effective, it's advisable to consult a healthcare provider, as chronic constipation can lead to complications and indicate underlying health issues. Keeping a consistent eating and bathroom schedule can also help regulate bowel movements.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium is often praised for its ability to support various bodily functions, and one of its lesser-known benefits is its potential to alleviate constipation. Magnesium acts as a natural laxative by attracting water into the intestines, which helps to soften stool and promote regular bowel movements. Various forms of magnesium supplements, such as magnesium citrate and magnesium hydroxide, are commonly used to relieve constipation. These forms are more bioavailable and have a reputation for being effective for those struggling with infrequent bowel movements.
That said, it's important to approach magnesium supplementation with care. While it can be beneficial, excessive magnesium intake can lead to adverse effects, including diarrhea and gastrointestinal discomfort. It’s always a good idea to consult with a healthcare provider or a dietitian before starting any supplementation, especially if you are considering magnesium as a treatment for constipation. They can help determine the appropriate dosage and form for your specific needs, ensuring that you reap the benefits while minimizing potential side effects.
Based on user reviews, many individuals report experiencing relief from constipation within a relatively short period. For instance, one user noted that their constipation became manageable after beginning regular use of the supplement, indicating results that may occur soon after consistent application Read Review. Another review stated that following the recommended usage effectively resolved their constipation Read Review. Additionally, users like the one who consumes the supplement daily for consistent bowel movements indicate that with regular use, positive results are achieved Read Review.
However, experiences can vary significantly from person to person. While some users find it effective in improving their condition quickly, others, like one reviewer, didn’t see results and even experienced worsened constipation Read Review. As is common with dietary supplements, efficacy may depend on individual body chemistry and adherence to dosage recommendations. Generally, if taken consistently, many users feel improvements within days or weeks.
Magnesium supplementation is increasingly gaining attention for its potential benefits in alleviating constipation, particularly in various populations. Research has shown that magnesium oxide can significantly enhance bowel movement frequency, with participants experiencing an average increase of 3.7 additional bowel movements per week compared to those not using it [8]. Notably, magnesium hydroxide syrup has also demonstrated efficacy in reducing constipation for patients in intensive care settings, highlighting its quick effect in promoting bowel movements [3]. Furthermore, studies have suggested that magnesium may work well when combined with other treatments, enhancing the overall effectiveness of constipation management strategies [7].
However, it's essential to recognize that while magnesium has shown promise, not all findings are uniformly positive, and its effectiveness can vary based on the individual and the context in which it is used. In some cases, the combination of magnesium with probiotics did not yield significantly better outcomes than when used alone [4]. Additionally, while magnesium products show moderate effectiveness in studies, they come with potential side effects such as diarrhea and nausea [16]. Overall, magnesium supplements appear to be a worthwhile consideration for managing constipation, but further research is warranted to fully understand their role and optimize usage.
Users have reported a variety of improvements in symptoms when using the supplement, particularly in relation to sleep quality and bowel regularity. Many individuals have highlighted significant relief from constipation, with one user mentioning that the supplement has made their constipation manageable compared to previously going days without a bowel movement Read Review. Another reviewer noted that following the recommended dosage effectively resolved their constipation issues Read Review. Regular users have found that taking the supplement daily prevents constipation, providing a more sustainable solution compared to traditional medications Read Review.
However, individual experiences can vary widely. While many users praise its effectiveness, some have reported no benefit or even a worsening of their symptoms, indicating that results may depend on personal body chemistry and adherence to dosage Read Review. Overall, it appears that with consistent use, many users experience notable relief in both sleep and digestive symptoms.
Users have shared various insights regarding the combination of this supplement with others for managing constipation. Some users report positive results when they combine this supplement with magnesium, stating that magnesium is a crucial element for relieving constipation Read Review. Several individuals mention that they have incorporated magnesium into their daily regimen alongside this supplement to enhance their overall digestive health, with one user noting that taking this supplement daily is essential for maintaining regular bowel movements Read Review.
However, it's important to highlight that not all users experienced consistent benefits. For instance, one reviewer expressed disappointment, stating that the supplement did not work for their constipation and their symptoms worsened Read Review. This underscores the variability in individual responses to dietary supplements, where effectiveness can vary significantly from person to person. Ultimately, combining this supplement with magnesium might work well for some users, but results may not be universal.
Based on user reviews, there seems to be a general consensus regarding the effective use of magnesium for treating constipation. Users often report that following the recommended dosage leads to significant improvements in regularity and stool consistency. For instance, one user notes that taking one pill daily has made a considerable difference in their constipation and has resulted in softer stools, showcasing the efficacy of a consistent daily intake, particularly when they skip it and experience struggles instead Read Review. Another user suggests taking magnesium before bedtime, recommending a daily or alternate day routine for optimal results Read Review.
However, it’s important to note that experiences can differ significantly among individuals. Some users have encountered issues where the magnesium did not work as intended, leading to worsened constipation and insomnia Read Review. Overall, while magnesium can be an effective solution for many, individual responses vary, and it may take some experimentation with dosage and timing to find what works best.
7.5
Improves regularity
1 people found this helpful
I use it for better sleep and to keep me “regular.” It truly has enhanced my sleep quality and enabled me to have a more consistent bowel movement. Previously, I could go days without a visit to the loo, but now my constipation is manageable. I must be cautious, as it can occasionally be a bit too effective. I don’t take it every night.
10
Effective remedy
Constipation is resolved effectively if you follow the recommended use.
9
Natural bowel movements
It’s effective for my constipation, which arises when I consume flour. Taking a tablet daily ensures natural bowel movements. If I skip it, I struggle. It's more affordable than over-the-counter and prescription medications while providing the same benefits, so I will continue using it.
0
No relief experienced
It didn't work for me at all! I bought it for insomnia and constipation relief, but it was ineffective. My constipation worsened, and I still struggled with insomnia. I'm puzzled as to how results differ so much from person to person.
9
Relieves constipation
I regularly take magnesium, as it is essential for relieving constipation!
7.5
Helps with constipation
6 people found this helpful
The second time I ordered this, I noticed several benefits. My period pain seemed to lessen, though I can't say if it's specifically due to this, as I only used magnesium upon a blogger's recommendation. It really aids my sleep, allowing me to rest deeply, and significantly relieves my constipation while relaxing my muscles. I recommend taking one pill before bedtime daily, or every other day. The size of the pill is good too.
9
Magnesium effectively aids constipation
The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
We investigated how magnesium supplements affect chronic constipation through a systematic review of randomized controlled trials. The analysis included eight studies with a total of 787 participants. We focused on magnesium oxide among other treatment options and assessed its effectiveness in increasing stool frequency and improving consistency.
The findings were quite promising for magnesium oxide. Our results showed that participants who took magnesium experienced a boost in bowel movements, with an average increase of about 3.7 additional movements per week. This improvement in stool consistency was also noteworthy, scoring higher on the Bristol stool chart.
While other supplements like senna and kiwifruit were explored, they didn't significantly enhance symptoms of constipation in this analysis. Therefore, we suggest that magnesium oxide stands out in this study as a worthwhile option for managing chronic constipation. But it’s essential to remember that further research could help confirm these findings and explore the effects of whole food alternatives.
4
Magnesium aids constipation relief
Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units.
We investigated how magnesium hydroxide syrup affects constipation among patients recovering from acute myocardial infarction in an intensive care unit (ICU). Participants were divided into two groups: one received magnesium hydroxide syrup daily, while the other was given flaxseed powder. Our aim was to determine which treatment better supported bowel movements in these patients.
The findings revealed that magnesium hydroxide syrup indeed plays a role in managing constipation. Patients taking this syrup experienced their first bowel movement significantly sooner, averaging just under 25 hours. Although both treatments increased bowel movement frequency and improved stool consistency, the differences between the two groups were not statistically significant. In other words, while magnesium did help prompt quicker bowel movements, it wasn't drastically better than flaxseed powder in terms of the overall outcomes.
Overall, the study highlights magnesium hydroxide syrup as a viable option for easing constipation for patients in recovery, though its effectiveness is comparable to that of flaxseed powder. The time to the first defecation was notably quicker with magnesium, suggesting its potential utility in clinical settings where prompt relief is crucial.
7
Magnesium aids constipation relief
Combined resistant dextrin and low-dose Mg oxide administration increases short-chain fatty acid and lactic acid production by gut microbiota.
We investigated the combined effects of resistant dextrin and magnesium oxide (MgO) on constipation relief and the production of beneficial compounds in the gut. In our study, we used mice and human subjects who incorporated resistant dextrin and Mg supplements into their diets.
Our findings indicated that magnesium is crucial for the gut microbiota to effectively produce short-chain fatty acids (SCFA) and lactic acid—compounds that support digestion and overall health. In mice, low doses of MgO were found to enhance the production of these beneficial substances, while higher doses seemed to hinder that production.
Among human participants, the intake of resistant dextrin alongside magnesium supplements led to a notable increase in SCFA and lactic acid production, reinforcing the idea that magnesium plays a supportive role in alleviating constipation through dietary fiber fermentation.
Overall, this research highlights magnesium's importance, especially when combined with resistant dextrin, for improving gut health and relieving constipation.
8
Magnesium's role in constipation treatment
Effect of magnesium oxide with probiotics on bowel movements in elderly orthopedic patients with chronic constipation: a retrospective chart review.
We aimed to understand how magnesium, particularly when combined with probiotics, influences bowel movements in elderly orthopedic patients suffering from chronic constipation. A retrospective chart review allowed us to analyze various patient records, focusing specifically on the treatments they received and the outcomes.
Magnesium is often talked about as a potential remedy for constipation because it can help draw water into the intestines, making it easier to pass stools. However, since our study also involved probiotics, which can also impact gut health, it becomes harder to isolate the specific effects of magnesium alone.
After reviewing the data, we observed that the combination of magnesium and probiotics did not show a significant advantage in improving bowel movements for the patients involved. This indicates that while magnesium may play a supportive role, its effectiveness on constipation could vary depending on individual circumstances and may not be as pronounced when combined with other treatments.
Overall, this study serves as a reminder of the complexity of managing constipation, especially in the elderly population, where multiple factors can come into play.
7
Moderate effectiveness of magnesium examined
Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review.
We conducted a systematic review to evaluate the effectiveness of over-the-counter (OTC) treatments for chronic constipation. Our analysis of studies from 2004 to 2020 revealed good evidence for using polyethylene glycol and senna.
Magnesium-based products showed moderate effectiveness. Though the evidence is promising, issues like study design and small sample sizes were noted. Also, common side effects included diarrhea and nausea but no serious events were reported.
Overall, magnesium may help with constipation, but further study is needed.
References
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Watanabe N, Itano A, Ando M, Kawahara M. Effect of reduced daily magnesium oxide doses on laxative effect: a single-center retrospective study. J Rural Med. 2024;19:192. 10.2185/jrm.2023-038
Amjadi Suraki S, Bagheri-Nesami M, Nabati M, Moosazadeh M, Habibi E. Flaxseed powder and magnesium hydroxide syrup on the intestinal function of patients with acute myocardial infarction in intensive care units. Caspian J Intern Med. 2024;15:234. 10.22088/cjim.15.2.234
Nagamine T. Effect of magnesium oxide with probiotics on bowel movements in elderly orthopedic patients with chronic constipation: a retrospective chart review. Biosci Microbiota Food Health. 2024;43:1. 10.12938/bmfh.2023-040
Park CW, Lee J, Hong YH, Kim YS, Suh HJ, et al. Coadministration of Lactulose with Probiotics Ameliorates Loperamide-Induced Constipation in Mice. Prev Nutr Food Sci. 2023;28:427. 10.3746/pnf.2023.28.4.427
Ishii H, Sawada R, Shiomi M, Shibuya K. A case-control study showing low creatinine clearance and high magnesium intake as risk factors for hypermagnesemia in older individuals. Magnes Res. 2023;36:23. 10.1684/mrh.2023.0513
Sasaki H, Hayashi K, Imamura M, Hirota Y, Hosoki H, et al. Combined resistant dextrin and low-dose Mg oxide administration increases short-chain fatty acid and lactic acid production by gut microbiota. J Nutr Biochem. 2023;120:109420. 10.1016/j.jnutbio.2023.109420
van der Schoot A, Creedon A, Whelan K, Dimidi E. The effect of food, vitamin, or mineral supplements on chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials. Neurogastroenterol Motil. 2023;35:e14613. 10.1111/nmo.14613
Suzuki S, Obara T, Ishikawa T, Noda A, Matsuzaki F, et al. No association between major congenital malformations and exposure to Kampo medicines containing rhubarb rhizome: A Japanese database study. Front Pharmacol. 2023;14:1107494. 10.3389/fphar.2023.1107494
Kistemaker KRJ, de Graeff A, Crul M, de Klerk G, van de Ven PM, et al. Magnesium hydroxide versus macrogol/electrolytes in the prevention of opioid-induced constipation in incurable cancer patients: study protocol for an open-label, randomized controlled trial (the OMAMA study). BMC Palliat Care. 2023;22:22. 10.1186/s12904-023-01143-2
Wu S, Jin T, Ma B, Ji Y, Huang X, et al. Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients-A randomized, double-blind, placebo-controlled trial. Cancer Med. 2023;12:4343. 10.1002/cam4.4922
Maezawa M, Inoue M, Satake R, Wakabayashi W, Oura K, et al. Effect of acid suppressant medications on the laxative action of magnesium preparations in patients with opioid-induced constipation: A pharmacovigilance analysis of the FDA Adverse Event Reporting System. Pharmazie. 2023;78:245. 10.1691/ph.2023.3624
Takemura M, Niki K, Miyaguchi S, Ueda M. Naldemedine-laxative combination: retrospective inpatient study. BMJ Support Palliat Care. 2024;13:e816. 10.1136/spcare-2022-003685
Worona-Dibner L, Vázquez-Frias R, Valdez-Chávez L, Verdiguel-Oyola M. Efficacy, safety, and acceptability of polyethylene glycol 3350 without electrolytes vs magnesium hydroxide in functional constipation in children from six months to eighteen years of age: A controlled clinical trial. Rev Gastroenterol Mex (Engl Ed). 2023;88:107. 10.1016/j.rgmxen.2021.12.005
de Campos GRC, Sandy NS, Lomazi EA, Bellomo-Brandao MA. Management of children with functional constipation referred to tertiary care. J Pediatr (Rio J). 2022;98:289. 10.1016/j.jped.2021.06.006
Rao SSC, Brenner DM. Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review. Am J Gastroenterol. 2021;116:1156. 10.14309/ajg.0000000000001222
Hassanein SMA, Deifallah SM, Bastawy HA. Efficacy of oral magnesium therapy in the treatment of chronic constipation in spastic cerebral palsy children: a randomized controlled trial. World J Pediatr. 2021;17:92. 10.1007/s12519-020-00401-0
Morishita D, Tomita T, Mori S, Kimura T, Oshima T, et al. Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial. Am J Gastroenterol. 2021;116:152. 10.14309/ajg.0000000000000942
Kubota M, Ito K, Tomimoto K, Kanazaki M, Tsukiyama K, et al. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial. Nutrients. 2020;12. 10.3390/nu12010225
Ohkubo H, Yoshihara T, Misawa N, Ashikari K, Fuyuki A, et al. Relationship between Stool Form and Quality of Life in Patients with Chronic Constipation: An Internet Questionnaire Survey. Digestion. 2021;102:147. 10.1159/000502815
Dupont C, Constant F, Imbert A, Hébert G, Zourabichvili O, et al. Time to treatment response of a magnesium- and sulphate-rich natural mineral water in functional constipation. Nutrition. 2019;65:167. 10.1016/j.nut.2019.02.018
Tsuji S, Horiuchi A, Tamaki M, Ichise Y, Kajiyama M, et al. Effectiveness and safety of a new regimen of polyethylene glycol plus ascorbic acid for same-day bowel cleansing in constipated patients. Acta Gastroenterol Belg. 2018;81:485.